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Direct Measurement Of The Cosmic-Ray Carbon And Oxygen Spectra From 10 Gev/ N To 2.2 Tev/ N With The Calorimetric Electron Telescope On The International Space Station, O. Adriani, Y. Akaike, K. Asano, Y. Asaoka, M. G. Bagliesi, E. Berti, G. Bigongiari, W. R. Binns, M. Bongi, P. Brogi, A. Bruno, J. H. Buckley, N. Cannady, G. Castellini, C. Checchia, M. L. Cherry, G. Collazuol, K. Ebisawa, H. Fuke, S. Gonzi, T. G. Guzik, T. Hams, K. Hibino, M. Ichimura, K. Ioka, W. Ishizaki, M. H. Israel, K. Kasahara, J. Kataoka, R. Kataoka, Y. Katayose, C. Kato, N. Kawanaka Dec 2020

Direct Measurement Of The Cosmic-Ray Carbon And Oxygen Spectra From 10 Gev/ N To 2.2 Tev/ N With The Calorimetric Electron Telescope On The International Space Station, O. Adriani, Y. Akaike, K. Asano, Y. Asaoka, M. G. Bagliesi, E. Berti, G. Bigongiari, W. R. Binns, M. Bongi, P. Brogi, A. Bruno, J. H. Buckley, N. Cannady, G. Castellini, C. Checchia, M. L. Cherry, G. Collazuol, K. Ebisawa, H. Fuke, S. Gonzi, T. G. Guzik, T. Hams, K. Hibino, M. Ichimura, K. Ioka, W. Ishizaki, M. H. Israel, K. Kasahara, J. Kataoka, R. Kataoka, Y. Katayose, C. Kato, N. Kawanaka

Faculty Publications

In this paper, we present the measurement of the energy spectra of carbon and oxygen in cosmic rays based on observations with the Calorimetric Electron Telescope on the International Space Station from October 2015 to October 2019. Analysis, including the detailed assessment of systematic uncertainties, and results are reported. The energy spectra are measured in kinetic energy per nucleon from 10 GeV/n to 2.2 TeV/n with an all-calorimetric instrument with a total thickness corresponding to 1.3 nuclear interaction length. The observed carbon and oxygen fluxes show a spectral index change of ∼0.15 around 200 GeV/n established with a significance >3σ. …

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A Concept Of The Transition Radiation Detector For A Hadron Separation In A Forward Direction Of The Lhc Experiments, N. Belyaev, M. L. Cherry, S. A. Doronin, K. Filippov, P. Fusco, F. Gargano, S. Konovalov, F. Loparco, M. N. Mazziotta, A. Mufazalova, S. Nechaeva, D. Ponomarenko, C. Rembser, A. Romaniouk, A. A. Savchenko, E. Shulga, S. Smirnov, Yu Smirnov, P. Spinelli, L. Sultanaliyeva, P. Teterin, V. Tikhomirov, K. Vorobev, K. Zhukov Dec 2020

A Concept Of The Transition Radiation Detector For A Hadron Separation In A Forward Direction Of The Lhc Experiments, N. Belyaev, M. L. Cherry, S. A. Doronin, K. Filippov, P. Fusco, F. Gargano, S. Konovalov, F. Loparco, M. N. Mazziotta, A. Mufazalova, S. Nechaeva, D. Ponomarenko, C. Rembser, A. Romaniouk, A. A. Savchenko, E. Shulga, S. Smirnov, Yu Smirnov, P. Spinelli, L. Sultanaliyeva, P. Teterin, V. Tikhomirov, K. Vorobev, K. Zhukov

Faculty Publications

Studying of hadron production in forward direction at the LHC energy has a great interest both for understanding of the fundamental QCD processes and also in applied areas such as the description of ultra-high energy cosmic particle interactions. The energies of secondary hadrons in such studies almost reach the maximum energy available at the LHC of ∼6 TeV, which corresponds to a Lorentz γ-factor up to 104 and above. The only effective technique able to identify particles in this range is based on the transition radiation detectors (TRD). Prototypes of such kind of detector were built and tested at the …

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Registration Of The Transition Radiation With Gaas Detector: Data/Mc Comparison, J. Alozy, N. Belyaev, B. L. Bergmann, T. R.V. Billoud, P. Broulim, P. Burian, M. Campbell, G. Chelkov, M. Cherry, F. Dachs, S. Doronin, K. Filippov, P. Fusco, F. Gargano, E. H.M. Heijne, S. Konovalov, X. Llopart Cudie, F. Loparco, M. N. Mazziotta, L. Meduna, H. Pernegger, D. Ponomarenko, S. Pospisil, D. Rastorguev, C. Rembser, A. Romaniouk, A. A. Savchenko, E. J. Schioppa, S. Smirnov, Y. Smirnov, P. Smolyanskiy, P. Spinelli, M. Strikhanov Dec 2020

Registration Of The Transition Radiation With Gaas Detector: Data/Mc Comparison, J. Alozy, N. Belyaev, B. L. Bergmann, T. R.V. Billoud, P. Broulim, P. Burian, M. Campbell, G. Chelkov, M. Cherry, F. Dachs, S. Doronin, K. Filippov, P. Fusco, F. Gargano, E. H.M. Heijne, S. Konovalov, X. Llopart Cudie, F. Loparco, M. N. Mazziotta, L. Meduna, H. Pernegger, D. Ponomarenko, S. Pospisil, D. Rastorguev, C. Rembser, A. Romaniouk, A. A. Savchenko, E. J. Schioppa, S. Smirnov, Y. Smirnov, P. Smolyanskiy, P. Spinelli, M. Strikhanov

Faculty Publications

New developments of pixel detectors based on GaAs sensors offer effective registration of the transition radiation (TR) X-rays and perform simultaneous measurements of their energies and emission angles. This unique feature opens new possibilities for particle identification on the basis of maximum available information about generated TR photons. Results of studies of TR energy-Angular distributions using a 500 |j.m thick GaAs sensor attached to a Timepix3 chip are presented. Measurements, analysis techniques and a comparison with Monte Carlo (MC) simulations are described and discussed.

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Rényi Entropy On C*-Algebras, Farrukh Mukhamedov, Kyouhei Ohmura, Noboru Watanabe Dec 2020

Rényi Entropy On C*-Algebras, Farrukh Mukhamedov, Kyouhei Ohmura, Noboru Watanabe

Journal of Stochastic Analysis

No abstract provided.

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Camkiiα-Positive Interneurons Identified Via A Microrna-Based Viral Gene Targeting Strategy, Marianna K. Keaveney, Bahar Rahsepar, Hua-An Tseng, Fernando R. Fernandez, Rebecca A. Mount, Tina Ta, John A. White, Jim Berg, Xue Han Dec 2020

Camkiiα-Positive Interneurons Identified Via A Microrna-Based Viral Gene Targeting Strategy, Marianna K. Keaveney, Bahar Rahsepar, Hua-An Tseng, Fernando R. Fernandez, Rebecca A. Mount, Tina Ta, John A. White, Jim Berg, Xue Han

Faculty Publications

No abstract provided.

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Entropic Signatures Of The Skyrmion Lattice Phase In Mnsi1-Xalx And Fe1-Ycoysi, C. Dhital, J. F. Ditusa Dec 2020

Entropic Signatures Of The Skyrmion Lattice Phase In Mnsi1-Xalx And Fe1-Ycoysi, C. Dhital, J. F. Ditusa

Faculty Publications

The entropic signatures of magnetic phase transitions in the skyrmion lattice host compounds MnSi0.962Al0.038 and Fe0.7Co0.3Si were investigated through low field magnetization and ac susceptibility measurements. These data indicate that the conical to skyrmion transition that occurs with the application of magnetic field in MnSi0.962Al0.038 is characterized by clear discontinuity in the magnetic entropy as expected for first order topological phase transition. These same magnetoentropic features are negligibly small in isostructural Fe0.7Co0.3Si due to the level of chemical substitution related disorder and differences in the spin dynamics (range and timescales). Despite the obvious similarities in the magnetic structures of these …

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Reinforcement Learning Approach For Inspect/Correct Tasks, Hoda Nasereddin Dec 2020

Reinforcement Learning Approach For Inspect/Correct Tasks, Hoda Nasereddin

LSU Doctoral Dissertations

In this research, we focus on the application of reinforcement learning (RL) in automated agent tasks involving considerable target variability (i.e., characterized by stochastic distributions); in particular, learning of inspect/correct tasks. Examples include automated identification & correction of rivet failures in airplane maintenance procedures, and automated cleaning of surgical instruments in a hospital sterilization processing department. The location of defects and the corrective action to be taken for each varies from task episode. What needs to be learned are optimal stochastic strategies rather than optimization of any one single defect type and location. RL has been widely applied in robotics …

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The Yang-Mills Heat Equation On Three-Manifolds With Boundary, Nelia Charalambous Dec 2020

The Yang-Mills Heat Equation On Three-Manifolds With Boundary, Nelia Charalambous

Journal of Stochastic Analysis

No abstract provided.

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Emergence Of Quantum Theories From Classical Probability: Historical Origins, Developments, And Open Problems, Luigi Accardi, Yun-Gang Lu Dec 2020

Emergence Of Quantum Theories From Classical Probability: Historical Origins, Developments, And Open Problems, Luigi Accardi, Yun-Gang Lu

Journal of Stochastic Analysis

No abstract provided.

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Comparing Multiple Comparisons: Practical Guidance For Choosing The Best Multiple Comparisons Test, Stephen Midway, Matthew Robertson, Shane Flinn, Michael Kaller Dec 2020

Comparing Multiple Comparisons: Practical Guidance For Choosing The Best Multiple Comparisons Test, Stephen Midway, Matthew Robertson, Shane Flinn, Michael Kaller

Faculty Publications

Multiple comparisons tests (MCTs) include the statistical tests used to compare groups (treatments) often following a significant effect reported in one of many types of linear models. Due to a variety of data and statistical considerations, several dozen MCTs have been developed over the decades, with tests ranging from very similar to each other to very different from each other. Many scientific disciplines use MCTs, including >40,000 reports of their use in ecological journals in the last 60 years. Despite the ubiquity and utility of MCTs, several issues remain in terms of their correct use and reporting. In this study, …

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Publisher Correction: Exuberant Fibroblast Activity Compromises Lung Function Via Adamts4 (Nature, (2020), 587, 7834, (466-471), 10.1038/S41586-020-2877-5), David F. Boyd, E. Kaitlynn Allen, Adrienne G. Randolph, Xi Zhi J. Guo, Yunceng Weng, Catherine J. Sanders, Resha Bajracharya, Natalie K. Lee, Clifford S. Guy, Peter Vogel, Wenda Guan, Yimin Li, Xiaoqing Liu, Tanya Novak, Margaret M. Newhams, Thomas P. Fabrizio, Nicholas Wohlgemuth, Peter M. Mourani, Michele Kong, Ronald C. Sanders, Katherine Irby, Katri Typpo, Barry Markovitz, Natalie Cvijanovich, Heidi Flori, Adam Schwarz, Nick Anas, Peter Mourani, Angela Czaja, Gwenn Mclaughlin, Matthew Paden, Keiko Tarquinio, Bria M. Coates, Neethi Pinto Dec 2020

Publisher Correction: Exuberant Fibroblast Activity Compromises Lung Function Via Adamts4 (Nature, (2020), 587, 7834, (466-471), 10.1038/S41586-020-2877-5), David F. Boyd, E. Kaitlynn Allen, Adrienne G. Randolph, Xi Zhi J. Guo, Yunceng Weng, Catherine J. Sanders, Resha Bajracharya, Natalie K. Lee, Clifford S. Guy, Peter Vogel, Wenda Guan, Yimin Li, Xiaoqing Liu, Tanya Novak, Margaret M. Newhams, Thomas P. Fabrizio, Nicholas Wohlgemuth, Peter M. Mourani, Michele Kong, Ronald C. Sanders, Katherine Irby, Katri Typpo, Barry Markovitz, Natalie Cvijanovich, Heidi Flori, Adam Schwarz, Nick Anas, Peter Mourani, Angela Czaja, Gwenn Mclaughlin, Matthew Paden, Keiko Tarquinio, Bria M. Coates, Neethi Pinto

Faculty Publications

© 2020, The Author(s), under exclusive licence to Springer Nature Limited. An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Geographic Patterns And Environmental Correlates Of Phylogenetic Relatedness And Diversity For Freshwater Fish Assemblages In North America, Hong Qian, Yong Cao, Daijiang Li, Cindy Chu, Brody Sandel, Xianli Wang Dec 2020

Geographic Patterns And Environmental Correlates Of Phylogenetic Relatedness And Diversity For Freshwater Fish Assemblages In North America, Hong Qian, Yong Cao, Daijiang Li, Cindy Chu, Brody Sandel, Xianli Wang

Faculty Publications

© 2020 The Authors. Ecography published by John Wiley & Sons Ltd on behalf of Nordic Society Oikos The tropical niche conservatism hypothesis suggests that most groups should be most phylogenetically clustered in cold, dry environments. This idea has been well-tested in plants and some animal groups, but not for fishes. We assess the geographic patterns of freshwater fish phylogenetic structure and investigate the relationships between these patterns and environmental variables across North America and within two biogeographic realms. Phylogenetic relatedness and diversity of 360 freshwater fish assemblages across North America were quantified with three metrics based on a well-dated …

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Strengthening Spatial Reasoning: Elucidating The Attentional And Neural Mechanisms Associated With Mental Rotation Skill Development, Katherine C. Moen, Melissa R. Beck, Stephanie M. Saltzmann, Tovah M. Cowan, Lauryn M. Burleigh, Leslie G. Butler, Jagannathan Ramanujam, Alex S. Cohen, Steven G. Greening Dec 2020

Strengthening Spatial Reasoning: Elucidating The Attentional And Neural Mechanisms Associated With Mental Rotation Skill Development, Katherine C. Moen, Melissa R. Beck, Stephanie M. Saltzmann, Tovah M. Cowan, Lauryn M. Burleigh, Leslie G. Butler, Jagannathan Ramanujam, Alex S. Cohen, Steven G. Greening

Faculty Publications

© 2020, The Author(s). Spatial reasoning is a critical skill in many everyday tasks and in science, technology, engineering, and mathematics disciplines. The current study examined how training on mental rotation (a spatial reasoning task) impacts the completeness of an encoded representation and the ability to rotate the representation. We used a multisession, multimethod design with an active control group to determine how mental rotation ability impacts performance for a trained stimulus category and an untrained stimulus category. Participants in the experimental group (n = 18) showed greater improvement than the active control group (n = 18) on the mental …

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Challenges And Opportunities With Causal Discovery Algorithms: Application To Alzheimer’S Pathophysiology, Xinpeng Shen, Sisi Ma, Prashanthi Vemuri, Gyorgy Simon, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, Andrew J. Saykin, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, David Holtzman, M. Marcel Mesulam, William Potter, Peter Snyder, Adam Schwartz, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter Dec 2020

Challenges And Opportunities With Causal Discovery Algorithms: Application To Alzheimer’S Pathophysiology, Xinpeng Shen, Sisi Ma, Prashanthi Vemuri, Gyorgy Simon, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, Andrew J. Saykin, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, David Holtzman, M. Marcel Mesulam, William Potter, Peter Snyder, Adam Schwartz, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter

Clinical Research Faculty Publications

Causal Structure Discovery (CSD) is the problem of identifying causal relationships from large quantities of data through computational methods. With the limited ability of traditional association-based computational methods to discover causal relationships, CSD methodologies are gaining popularity. The goal of the study was to systematically examine whether (i) CSD methods can discover the known causal relationships from observational clinical data and (ii) to offer guidance to accurately discover known causal relationships. We used Alzheimer’s disease (AD), a complex progressive disease, as a model because the well-established evidence provides a “gold-standard” causal graph for evaluation. We evaluated two CSD methods, Fast …

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The Superfgd Prototype Charged Particle Beam Tests, A. Blondel, M. Bogomilov, S. Bordoni, F. Cadoux, D. Douqa, K. Dugas, T. Ekelof, Y. Favre, S. Fedotov, K. Fransson, R. Fujita, E. Gramstad, A. K. Ichikawa, S. Ilieva, K. Iwamoto, C. Jesús-Valls, C. K. Jung, S. P. Kasetti, M. Khabibullin, A. Khotjantsev, A. Korzenev, A. Kostin, Y. Kudenko, T. Kutter, T. Lux, L. Maret, T. Matsubara, A. Mefodiev Dec 2020

The Superfgd Prototype Charged Particle Beam Tests, A. Blondel, M. Bogomilov, S. Bordoni, F. Cadoux, D. Douqa, K. Dugas, T. Ekelof, Y. Favre, S. Fedotov, K. Fransson, R. Fujita, E. Gramstad, A. K. Ichikawa, S. Ilieva, K. Iwamoto, C. Jesús-Valls, C. K. Jung, S. P. Kasetti, M. Khabibullin, A. Khotjantsev, A. Korzenev, A. Kostin, Y. Kudenko, T. Kutter, T. Lux, L. Maret, T. Matsubara, A. Mefodiev

Faculty Publications

A novel scintillator detector, the SuperFGD, has been selected as the main neutrino target for an upgrade of the T2K experiment ND280 near detector. The detector design will allow nearly 4π coverage for neutrino interactions at the near detector and will provide lower energy thresholds, significantly reducing systematic errors for the experiment. The SuperFGD is made of optically-isolated scintillator cubes of size 10×10×10 mm3, providing the required spatial and energy resolution to reduce systematic uncertainties for future T2K runs. The SuperFGD for T2K will have close to two million cubes in a 1920 × 560 × 1840 mm3 volume. A …

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First Results On Protodune-Sp Liquid Argon Time Projection Chamber Performance From A Beam Test At The Cern Neutrino Platform, B. Abi, A. Abed Abud, R. Acciarri, M. A. Acero, G. Adamov, M. Adamowski, D. Adams, P. Adrien, M. Adinolfi, Z. Ahmad, J. Ahmed, T. Alion, S. Alonso Monsalve, C. Alt, J. Anderson, C. Andreopoulos, M. P. Andrews, F. Andrianala, S. Andringa, A. Ankowski, M. Antonova, S. Antusch, A. Aranda-Fernandez, A. Ariga, L. O. Arnold, M. A. Arroyave, J. Asaadi, A. Aurisano Dec 2020

First Results On Protodune-Sp Liquid Argon Time Projection Chamber Performance From A Beam Test At The Cern Neutrino Platform, B. Abi, A. Abed Abud, R. Acciarri, M. A. Acero, G. Adamov, M. Adamowski, D. Adams, P. Adrien, M. Adinolfi, Z. Ahmad, J. Ahmed, T. Alion, S. Alonso Monsalve, C. Alt, J. Anderson, C. Andreopoulos, M. P. Andrews, F. Andrianala, S. Andringa, A. Ankowski, M. Antonova, S. Antusch, A. Aranda-Fernandez, A. Ariga, L. O. Arnold, M. A. Arroyave, J. Asaadi, A. Aurisano

Faculty Publications

The ProtoDUNE-SP detector is a single-phase liquid argon time projection chamber with an active volume of 7.2× 6.1× 7.0 m3. It is installed at the CERN Neutrino Platform in a specially-constructed beam that delivers charged pions, kaons, protons, muons and electrons with momenta in the range 0.3 GeV/c to 7 GeV/c. Beam line instrumentation provides accurate momentum measurements and particle identification. The ProtoDUNE-SP detector is a prototype for the first far detector module of the Deep Underground Neutrino Experiment, and it incorporates full-size components as designed for that module. This paper describes the beam line, the time projection chamber, the …

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Qcm Sensor Arrays, Electroanalytical Techniques And Nir Spectroscopy Coupled To Multivariate Analysis For Quality Assessment Of Food Products, Raw Materials, Ingredients And Foodborne Pathogen Detection: Challenges And Breakthroughs†, David K. Bwambok, Noureen Siraj, Samantha Macchi, Nathaniel E. Larm, Gary A. Baker, Rocío L. Pérez, Caitlan E. Ayala, Charuksha Walgama, David Pollard, Jason D. Rodriguez, Souvik Banerjee, Brianda Elzey, Isiah M. Warner, Sayo O. Fakayode Dec 2020

Qcm Sensor Arrays, Electroanalytical Techniques And Nir Spectroscopy Coupled To Multivariate Analysis For Quality Assessment Of Food Products, Raw Materials, Ingredients And Foodborne Pathogen Detection: Challenges And Breakthroughs†, David K. Bwambok, Noureen Siraj, Samantha Macchi, Nathaniel E. Larm, Gary A. Baker, Rocío L. Pérez, Caitlan E. Ayala, Charuksha Walgama, David Pollard, Jason D. Rodriguez, Souvik Banerjee, Brianda Elzey, Isiah M. Warner, Sayo O. Fakayode

Faculty Publications

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Quality checks, assessments, and the assurance of food products, raw materials, and food ingredients is critically important to ensure the safeguard of foods of high quality for safety and public health. Nevertheless, quality checks, assessments, and the assurance of food products along distribution and supply chains is impacted by various challenges. For instance, the development of portable, sensitive, low-cost, and robust instrumentation that is capable of real-time, accurate, and sensitive analysis, quality checks, assessments, and the assurance of food products in the field and/or in the production line in a food …

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The Effect Of Summer Drought On The Predictability Of Local Extinctions In A Butterfly Metapopulation, Erik Van Bergen, Tad Dallas, Michelle F. Dileo, Aapo Kahilainen, Anniina L.K. Mattila, Miska Luoto, Marjo Saastamoinen Dec 2020

The Effect Of Summer Drought On The Predictability Of Local Extinctions In A Butterfly Metapopulation, Erik Van Bergen, Tad Dallas, Michelle F. Dileo, Aapo Kahilainen, Anniina L.K. Mattila, Miska Luoto, Marjo Saastamoinen

Faculty Publications

© 2020 The Authors. Conservation Biology published by Wiley Periodicals LLC on behalf of Society for Conservation Biology The ecological impacts of extreme climatic events on population dynamics and community composition are profound and predominantly negative. Using extensive data of an ecological model system, we tested whether predictions from ecological models remain robust when environmental conditions are outside the bounds of observation. We observed a 10-fold demographic decline of the Glanville fritillary butterfly (Melitaea cinxia) metapopulation on the Åland islands, Finland in the summer of 2018 and used climatic and satellite data to demonstrate that this year was an anomaly …

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Fungicide Resistance In Cercospora Species Causing Cercospora Leaf Blight And Purple Seed Stain Of Soybean In Argentina, Francisco J. Sautua, Vinson P. Doyle, Paul P. Price, Alejandro Porfiri, Paula Fernandez, Maria M. Scandiani, Marcelo A. Carmona Dec 2020

Fungicide Resistance In Cercospora Species Causing Cercospora Leaf Blight And Purple Seed Stain Of Soybean In Argentina, Francisco J. Sautua, Vinson P. Doyle, Paul P. Price, Alejandro Porfiri, Paula Fernandez, Maria M. Scandiani, Marcelo A. Carmona

Faculty Publications

Cercospora species cause cercospora leaf blight (CLB) and purple seed stain (PSS) on soybean. Because there are few resistant soybean varieties available, CLB/PSS management relies heavily upon fungicide applications. Sensitivity of 62 Argentinian Cercospora isolates to demethylation inhibitor (DMI), methyl benzimidazole carbamate (MBC), quinone outside inhibitor (QoI), succinate dehydrogenase inhibitor (SDHI) fungicides, and mancozeb was determined in this study. All isolates were sensitive to difenoconazole, epoxiconazole, prothioconazole, tebuconazole, and cyproconazole (EC50 values ranged from 0.006 to 2.4 µg/ml). In contrast, 51% of the tested isolates were sensitive (EC50 values ranged from 0.003 to 0.2 µg/ml), and 49% were highly resistant …

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Larval Movement And Survival Of Helicoverpa Zea (Boddie) In Seed Blends Of Non-Bt And Bt Maize Containing Agrisure Viptera® Trait: Implications For Resistance Management, M. Dimase, I. Oyediran, S. Brown, W. Walker, J. Guo, W. Yu, Y. Zhang, J. Chen, Z. Wen, F. Huang Dec 2020

Larval Movement And Survival Of Helicoverpa Zea (Boddie) In Seed Blends Of Non-Bt And Bt Maize Containing Agrisure Viptera® Trait: Implications For Resistance Management, M. Dimase, I. Oyediran, S. Brown, W. Walker, J. Guo, W. Yu, Y. Zhang, J. Chen, Z. Wen, F. Huang

Faculty Publications

A seed blend refuge has been used to host susceptible insects for Bt maize insect resistance management (IRM) in the U.S. Maize Belt. One major concern in the use of seed blends is that larval movement among non-Bt and Bt plants could cause additional mortalities of susceptible insects. To address this concern, three caged-field trials were conducted to evaluate larval movement and survival of the corn earworm, Helicoverpa zea (Boddie), in eight seed blends of Cry1Ab/Vip3A maize with 0–30% non-Bt refuges. Each plot consisted of five rows and 21 plants in each row. Each plot was infested on the ear …

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Computer-Based And Paper-And-Pencil Tests: A Study In Calculus For Stem Majors, Lawrence Smolinsky, Brian D. Marx, Gestur Olafsson, Yanxia A. Ma Dec 2020

Computer-Based And Paper-And-Pencil Tests: A Study In Calculus For Stem Majors, Lawrence Smolinsky, Brian D. Marx, Gestur Olafsson, Yanxia A. Ma

Faculty Publications

Computer-based testing is an expanding use of technology offering advantages to teachers and students. We studied Calculus II classes for science, technology, engineering, and mathematics majors using different testing modes. Three sections with 324 students employed: paper-and-pencil testing, computer-based testing, and both. Computer tests gave immediate feedback and allowed multiple submissions and pooling. Paper-and-pencil tests (PPTs) required work and explanation allowing inspection of high cognitive demand tasks. Each test mode used the strength of its method. Students were given the same lecture by the same instructor on the same day and the same homework assignments and due dates. The design …

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Estrogen Receptor-Α Expressing Neurons In The Ventrolateral Vmh Regulate Glucose Balance, Yanlin He, Pingwen Xu, Chunmei Wang, Yan Xia, Meng Yu, Yongjie Yang, Kaifan Yu, Xing Cai, Na Qu, Kenji Saito, Julia Wang, Ilirjana Hyseni, Matthew Robertson, Badrajee Piyarathna, Min Gao, Sohaib A. Khan, Feng Liu, Rui Chen, Cristian Coarfa, Zhongming Zhao, Qingchun Tong, Zheng Sun, Yong Xu Dec 2020

Estrogen Receptor-Α Expressing Neurons In The Ventrolateral Vmh Regulate Glucose Balance, Yanlin He, Pingwen Xu, Chunmei Wang, Yan Xia, Meng Yu, Yongjie Yang, Kaifan Yu, Xing Cai, Na Qu, Kenji Saito, Julia Wang, Ilirjana Hyseni, Matthew Robertson, Badrajee Piyarathna, Min Gao, Sohaib A. Khan, Feng Liu, Rui Chen, Cristian Coarfa, Zhongming Zhao, Qingchun Tong, Zheng Sun, Yong Xu

Division of Basic Science Faculty Publications

Brain glucose-sensing neurons detect glucose fluctuations and prevent severe hypoglycemia, but mechanisms mediating functions of these glucose-sensing neurons are unclear. Here we report that estrogen receptor-α (ERα)-expressing neurons in the ventrolateral subdivision of the ventromedial hypothalamic nucleus (vlVMH) can sense glucose fluctuations, being glucose-inhibited neurons (GI-ERαvlVMH) or glucose-excited neurons (GE-ERαvlVMH). Hypoglycemia activates GI-ERαvlVMH neurons via the anoctamin 4 channel, and inhibits GE-ERαvlVMH neurons through opening the ATP-sensitive potassium channel. Further, we show that GI-ERαvlVMH neurons preferentially project to the medioposterior arcuate nucleus of the hypothalamus (mpARH) and GE-ERαvlVMH neurons preferentially project to the dorsal Raphe nuclei (DRN). Activation of ERαvlVMH …

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Estrogen-Sensitive Medial Preoptic Area Neurons Coordinate Torpor In Mice, Zhi Zhang, Fernando M.C.V. Reis, Yanlin He, Jae W. Park, Johnathon R. Divittorio, Nilla Sivakumar, J. Edward Van Veen, Sandra Maesta-Pereira, Michael Shum, India Nichols, Megan G. Massa, Shawn Anderson, Ketema Paul, Marc Liesa, Olujimi A. Ajijola, Yong Xu, Avishek Adhikari, Stephanie M. Correa Dec 2020

Estrogen-Sensitive Medial Preoptic Area Neurons Coordinate Torpor In Mice, Zhi Zhang, Fernando M.C.V. Reis, Yanlin He, Jae W. Park, Johnathon R. Divittorio, Nilla Sivakumar, J. Edward Van Veen, Sandra Maesta-Pereira, Michael Shum, India Nichols, Megan G. Massa, Shawn Anderson, Ketema Paul, Marc Liesa, Olujimi A. Ajijola, Yong Xu, Avishek Adhikari, Stephanie M. Correa

Division of Basic Science Faculty Publications

Homeotherms maintain a stable internal body temperature despite changing environments. During energy deficiency, some species can cease to defend their body temperature and enter a hypothermic and hypometabolic state known as torpor. Recent advances have revealed the medial preoptic area (MPA) as a key site for the regulation of torpor in mice. The MPA is estrogen-sensitive and estrogens also have potent effects on both temperature and metabolism. Here, we demonstrate that estrogen-sensitive neurons in the MPA can coordinate hypothermia and hypometabolism in mice. Selectively activating estrogen-sensitive MPA neurons was sufficient to drive a coordinated depression of metabolic rate and body …

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Review Of The Validity And Feasibility Of Image-Assisted Methods For Dietary Assessment, Christoph Höchsmann, Corby K. Martin Dec 2020

Review Of The Validity And Feasibility Of Image-Assisted Methods For Dietary Assessment, Christoph Höchsmann, Corby K. Martin

Clinical Research Faculty Publications

Accurately quantifying dietary intake is essential to understanding the effect of diet on health and evaluating the efficacy of dietary interventions. Self-report methods (e.g., food records) are frequently utilized despite evident inaccuracy of these methods at assessing energy and nutrient intake. Methods that assess food intake via images of foods have overcome many of the limitations of traditional self-report. In cafeteria settings, digital photography has proven to be unobtrusive and accurate and is the method of choice for assessing food provision, plate waste, and food intake. In free-living conditions, image capture of food selection and plate waste via the user’s …

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Genetic Variation In Lean Body Mass, Changes Of Appetite And Weight Loss In Response To Diet Interventions: The Pounds Lost Trial, Xiang Li, Tao Zhou, Hao Ma, Yoriko Heianza, Catherine M. Champagne, Donald A. Williamson, George A. Bray, Frank M. Sacks, Lu Qi Dec 2020

Genetic Variation In Lean Body Mass, Changes Of Appetite And Weight Loss In Response To Diet Interventions: The Pounds Lost Trial, Xiang Li, Tao Zhou, Hao Ma, Yoriko Heianza, Catherine M. Champagne, Donald A. Williamson, George A. Bray, Frank M. Sacks, Lu Qi

Population and Public Health Science Faculty Publications

Aim: To investigate whether the genetic risk score (GRS) for lean body mass (LBM) modified the effects of weight-loss diets on changes in appetite and adiposity among overweight and obese individuals. Participants and Methods: In the 2-year Preventing Overweight Using Novel Dietary Strategies (POUNDS Lost) trial, we included 692 adults who were randomly assigned to one of four diets varying in macronutrient intake. A GRS was calculated using five single nucleotide polymorphisms associated with LBM. Results: The LBM-GRS was not associated with the baseline LBM measured by dual-energy x-ray absorptiometry in a subgroup (50%) of the study population. We found …

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Zinc Finger Transcription Factor Zbtb16 Coordinates The Response To Energy Deficit In The Mouse Hypothalamus, Helia Cheng, Schuyler J. Pablico, Jisu Lee, Ji Suk Chang, Sangho Yu Dec 2020

Zinc Finger Transcription Factor Zbtb16 Coordinates The Response To Energy Deficit In The Mouse Hypothalamus, Helia Cheng, Schuyler J. Pablico, Jisu Lee, Ji Suk Chang, Sangho Yu

Division of Basic Science Faculty Publications

The central nervous system controls feeding behavior and energy expenditure in response to various internal and external stimuli to maintain energy balance. Here we report that the newly identified transcription factor zinc finger and BTB domain containing 16 (Zbtb16) is induced by energy deficit in the paraventricular (PVH) and arcuate (ARC) nuclei of the hypothalamus via glucocorticoid (GC) signaling. In the PVH, Zbtb16 is expressed in the anterior half of the PVH and co-expressed with many neuronal markers such as corticotropin-releasing hormone (Crh), thyrotropin-releasing hormone (Trh), oxytocin (Oxt), arginine vasopressin (Avp), and nitric oxide synthase 1 (Nos1). Knockdown (KD) of …

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Outpatient Screening Of Health Status Among Postbariatric Patients During The Covid-19 Pandemic In Sao Paulo, Brazil, Karla Fabiana Goessler, Carolina Ferreira Nicoletti, Diego Augusto Nunes Rezende, Sofia Mendes Sieczkowska, Gabriel Perri Esteves, Rafael Genario, Gersiel Nascimento De Oliveira Júnior, Kamila Meireles, Ana Jéssica Pinto, Michele Nakahara-Melo, Roberto De Cleva, Marco Aurélio Santo, John P. Kirwan, Hamilton Roschel, Bruno Gualano Dec 2020

Outpatient Screening Of Health Status Among Postbariatric Patients During The Covid-19 Pandemic In Sao Paulo, Brazil, Karla Fabiana Goessler, Carolina Ferreira Nicoletti, Diego Augusto Nunes Rezende, Sofia Mendes Sieczkowska, Gabriel Perri Esteves, Rafael Genario, Gersiel Nascimento De Oliveira Júnior, Kamila Meireles, Ana Jéssica Pinto, Michele Nakahara-Melo, Roberto De Cleva, Marco Aurélio Santo, John P. Kirwan, Hamilton Roschel, Bruno Gualano

Division of Basic Science Faculty Publications

No abstract provided.

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Effect Of Overeating Dietary Protein At Different Levels On Circulating Lipids And Liver Lipid: The Proof Study, George A. Bray, Leanne M. Redman, Jennifer Rood, Elizabeth De Jonge, Steven R. Smith Dec 2020

Effect Of Overeating Dietary Protein At Different Levels On Circulating Lipids And Liver Lipid: The Proof Study, George A. Bray, Leanne M. Redman, Jennifer Rood, Elizabeth De Jonge, Steven R. Smith

Clinical Research Faculty Publications

Background: During overeating, a low protein diet slowed the rate of weight gain and increased the energy cost of the added weight, suggesting that low protein diets reduced energy efficiency. The Protein Overfeeding (PROOF) study explored the metabolic changes to low and high protein diets, and this sub-study examined the changes in body composition and blood lipids when eating high and low protein diets during overeating. Methods: Twenty-three healthy volunteers (M = 14; F = 9) participated in an 8-week, parallel arm study where they were overfed by ~40% with diets containing 5% (LPD = low protein diet), 15% (NPD …

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Author Correction: Multimodal Hippocampal Subfield Grading For Alzheimer’S Disease Classification (Scientific Reports, (2019), 9, 1, (13845), 10.1038/S41598-019-49970-9), Kilian Hett, Vinh Thong Ta, Gwenaëlle Catheline, Thomas Tourdias, José V. Manjón, Pierrick Coupé, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, Davie Holtzman, M. Marcel Mesulam, William Potter, Peter Snyder, Tom Montine, Ronald G. Thomas, Michael Donohue Dec 2020

Author Correction: Multimodal Hippocampal Subfield Grading For Alzheimer’S Disease Classification (Scientific Reports, (2019), 9, 1, (13845), 10.1038/S41598-019-49970-9), Kilian Hett, Vinh Thong Ta, Gwenaëlle Catheline, Thomas Tourdias, José V. Manjón, Pierrick Coupé, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, Davie Holtzman, M. Marcel Mesulam, William Potter, Peter Snyder, Tom Montine, Ronald G. Thomas, Michael Donohue

Clinical Research Faculty Publications

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Genetic Correlations And Genome-Wide Associations Of Cortical Structure In General Population Samples Of 22,824 Adults, Edith Hofer, Gennady V. Roshchupkin, Hieab H.H. Adams, Maria J. Knol, Honghuang Lin, Shuo Li, Habil Zare, Shahzad Ahmad, Nicola J. Armstrong, Claudia L. Satizabal, Manon Bernard, Joshua C. Bis, Nathan A. Gillespie, Michelle Luciano, Aniket Mishra, Markus Scholz, Alexander Teumer, Rui Xia, Xueqiu Jian, Thomas H. Mosley, Yasaman Saba, Lukas Pirpamer, Stephan Seiler, James T. Becker, Owen Carmichael, Jerome I. Rotter, Bruce M. Psaty, Oscar L. Lopez, Najaf Amin, Sven J. Van Der Lee, Qiong Yang, Jayandra J. Himali, Pauline Maillard, Alexa S. Beiser Dec 2020

Genetic Correlations And Genome-Wide Associations Of Cortical Structure In General Population Samples Of 22,824 Adults, Edith Hofer, Gennady V. Roshchupkin, Hieab H.H. Adams, Maria J. Knol, Honghuang Lin, Shuo Li, Habil Zare, Shahzad Ahmad, Nicola J. Armstrong, Claudia L. Satizabal, Manon Bernard, Joshua C. Bis, Nathan A. Gillespie, Michelle Luciano, Aniket Mishra, Markus Scholz, Alexander Teumer, Rui Xia, Xueqiu Jian, Thomas H. Mosley, Yasaman Saba, Lukas Pirpamer, Stephan Seiler, James T. Becker, Owen Carmichael, Jerome I. Rotter, Bruce M. Psaty, Oscar L. Lopez, Najaf Amin, Sven J. Van Der Lee, Qiong Yang, Jayandra J. Himali, Pauline Maillard, Alexa S. Beiser

Clinical Research Faculty Publications

Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain …

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