Digital Commons Network^™

More Time In Glucose Range During Exercise Days Than Sedentary Days In Adults Living With Type 1 Diabetes, Michael C. Riddell, Zoey Li, Roy W. Beck, Robin L. Gal, Peter G. Jacobs, Jessica R. Castle, Melanie B. Gillingham, Mark Clements, Susana R. Patton, Eyal Dassau, Francis J. Doyle, Corby K. Martin, Peter Calhoun, Michael R. Rickels

Clinical Research Faculty Publications

Objective: This study analysis was designed to examine the 24-h effects of exercise on glycemic control as measured by continuous glucose monitoring (CGM). Methods: Individuals with type 1 diabetes (ages: 15-68 years; hemoglobin A1c: 7.5% ± 1.5% [mean ± standard deviation (SD)]) were randomly assigned to complete twice-weekly aerobic, high-intensity interval, or resistance-based exercise sessions in addition to their personal exercise sessions for a period of 4 weeks. Exercise was tracked with wearables and glucose concentrations assessed using CGM. An exercise day was defined as a 24-h period after the end of exercise, while a sedentary day was defined as …

Different Indicators Of Adiposity And Fat Distribution And Cardiometabolic Risk Factors In Patients With Type 2 Diabetes, Li Ding, Yuxin Fan, Jing He, Ruodan Wang, Qing He, Jingqiu Cui, Zhongshu Ma, Fangqiu Zheng, Hua Gao, Chenlin Dai, Hongyan Wei, Jun Li, Yuming Cao, Gang Hu, Ming Liu

Population and Public Health Science Faculty Publications

Objective: This study aimed to evaluate the effect of adiposity and fat distribution on the odds of elevated cardiovascular risk factors among adults with type 2 diabetes mellitus. Methods: The present cross-sectional study included 2,427 adults with type 2 diabetes mellitus. Body fat was assessed by dual-energy x-ray absorptiometry. Multivariate-adjusted logistic regression was used to estimate effects of adiposity parameters on elevated hemoglobin A1c (HbA1c, ≥7.0%), hypertension (blood pressure ≥140/90 mmHg), and elevated low-density lipoprotein (LDL) cholesterol (≥2.6 mmol/L). Results: The multivariable-adjusted odds ratio (OR) for elevated HbA1c was 0.82 (95% CI: 0.70-0.96) for each SD increase in leg fat …

Four Distinct Trajectories Of Tau Deposition Identified In Alzheimer’S Disease, Jacob W. Vogel, Alexandra L. Young, Neil P. Oxtoby, Ruben Smith, Rik Ossenkoppele, Olof T. Strandberg, Renaud La Joie, Leon M. Aksman, Michel J. Grothe, Yasser Iturria-Medina, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson

Clinical Research Faculty Publications

Alzheimer’s disease (AD) is characterized by the spread of tau pathology throughout the cerebral cortex. This spreading pattern was thought to be fairly consistent across individuals, although recent work has demonstrated substantial variability in the population with AD. Using tau-positron emission tomography scans from 1,612 individuals, we identified 4 distinct spatiotemporal trajectories of tau pathology, ranging in prevalence from 18 to 33%. We replicated previously described limbic-predominant and medial temporal lobe-sparing patterns, while also discovering posterior and lateral temporal patterns resembling atypical clinical variants of AD. These ‘subtypes’ were stable during longitudinal follow-up and were replicated in a separate sample …

Heterotrophic Nitrogen Fixation In Response To Nitrate Loading And Sediment Organic Matter In An Emerging Coastal Deltaic Floodplain Within The Mississippi River Delta Plain, Song Li, Robert R. Twilley, Aixin Hou

Faculty Publications

Increasing nitrate (NO3⁻) loading in rivers due to agricultural fertilization alters benthic nitrogen (N) cycling and shifts coastal wetlands from being a net source to net sink of reactive N. Heterotrophic N2 fixation that converts N2 to reactive N is often assumed negligible in eutrophic ecosystems and excluded in coastal N budget evaluations. We investigated N2 fixation and denitrification in response to increasing NO3⁻ loading (0, 10, and 100 μM) and sediment organic matter (OMsediment) concentrations in the emerging Wax Lake Delta. Continuous flow-through incubations with ³⁰N2 addition was applied to measure N2 fixation. The variation …

Genome-Wide Association Mapping Reveals Race-Specific Snp Markers Associated With Anthracnose Resistance In Carioca Common Beans, Caleo Panhoca De Almeida, Jean Fausto De Carvalho Paulino, Caio Cesar Ferrari Barbosa, Gabriel De Moraes Cunha Goncalves, Roberto Fritsche-Neto, Sergio Augusto Morais Carbonell, Alisson Fernando Chiorato, Luciana Lasry Benchimol-Reis

Faculty Publications

Brazil is the largest consumer of dry edible beans (Phaseolus vulgaris L.) in the world, 70% of consumption is of the carioca variety. Although the variety has high yield, it is susceptible to several diseases, among them, anthracnose (ANT) can lead to losses of up to 100% of production. The most effective strategy to overcome ANT, a disease caused by the fungus Colletotrichum lindemuthianum, is the development of resistant cultivars. For that reason, the selection of carioca genotypes resistant to multiple ANT races and the identification of loci/markers associated with genetic resistance are extremely important for the genetic breeding process. …

Genome-Wide Association Study Reveals Genomic Regions Associated With Fusarium Wilt Resistance In Common Bean, Jean Fausto De Carvalho Paulino, Caléo Panhoca De Almeida, César Júnior Bueno, Qijian Song, Roberto Fritsche-Neto, Sérgio Augusto Morais Carbonell, Alisson Fernando Chiorato, Luciana Lasry Benchimol-Reis

Faculty Publications

Fusarium wilt (Fusarium oxysporum f. sp. phaseoli, Fop) is one of the main fungal soil diseases in common bean. The aim of the present study was to identify genomic regions associated with Fop resistance through genome-wide association studies (GWAS) in a Mesoamerican Diversity Panel (MDP) and to identify potential common bean sources of Fop’s resistance. The MDP was genotyped with BARCBean6K_3BeadChip and evaluated for Fop resistance with two different monosporic strains using the root-dip method. Disease severity rating (DSR) and the area under the disease progress curve (AUDPC), at 21 days after inoculation (DAI), were used for GWAS performed with …

Heat Flux From A Vapor-Dominated Hydrothermal Field Beneath Yellowstone Lake, Julia E. Favorito, Robert N. Harris, Robert A. Sohn, Shaul Hurwitz, Karen M. Luttrell

Faculty Publications

We report results from 149 heat flux measurements made over n ∼2-year interval at sites in and around a vapor-dominated geothermal field located at water depths of ∼100–120 m in Yellowstone Lake, Wyoming. Measurements of both in situ temperature and thermal conductivity as a function of depth were made with a 1 m probe via a remotely operated vehicle, and are combined to compute the vertical conductive heat flux. Inside the ∼55.5 × 10³ m² bathymetric depression demarcating the vapor-dominated field, the median conductive flux is 13 W m⁻², with a conductive output of 0.72 MW. …

Restoring Trust In Truth-Seekers: Effects Of Op/Eds Defending Journalism And Justice, Raymond J. Pingree, Martina Santia, Kirill Bryanov, Brian K. Watson

Faculty Publications

A healthy democracy requires trust that people can be impartial in important truth-seeking institutions including journalism, justice, and science. Recently some U.S. elites have adopted alarmingly extreme rhetoric against truth-seekers, denouncing mainstream journalism as fake news, criminal investigations as partisan witch-hunts, climate science as a hoax, and career civil servants as a deep state conspiracy. In response, some news organizations have taken the unusual step of publishing op/eds defending these institutions. Two experiments tested effects of such op/eds. In study 1, participants spent twelve days using a purpose-built news portal containing real, timely news with random assignment to the availability …

Mobile App Privacy In Software Engineering Research: A Systematic Mapping Study, Fahimeh Ebrahimi, Miroslav Tushev, Anas Mahmoud

Faculty Publications

Context: Mobile applications (apps) have become deeply personal, constantly demanding access to privacy-sensitive information in exchange for more personalized user experiences. Such privacy-invading practices have generated major multidimensional privacy concerns among app users. Objective: The research on mobile app privacy has experienced rapid growth over the past decade. This line of research is aimed at systematically exposing the privacy practices of apps and proposing solutions to protect the privacy of mobile app users. In this paper, we conduct a systematic mapping study of this body of research. Our objectives are to a) explore trends in SE app privacy research, b) …

Analysis, Modeling, And Simulation (Ams) Case Studies Of Connected And Automated Vehicle (Cav) Implementations Specific To The South Central Region, Christopher Melson, Jiaqi Ma

Publications

Connected and automated vehicles (CAVs) offer potentially transformative and far-reaching impacts to the transportation system. However, realized benefits will be directly tied to how well agencies prepare for these technologies. This report documents efforts that support CAV preparatory actions in Louisiana and includes: (1) conducting a stakeholder survey to inform engagement activities to develop strategic partnerships in CAV deployment and (2) conducting crash analyses for deployment scenarios of CAV-based queue warning systems (QWSs).

An electronic survey was developed and disseminated to 273 Louisiana organizations. The purpose of the survey was to engage these organizations under the context of CAV planning …

Moiré Superlattice On The Surface Of A Topological Insulator, Jennifer Cano, Shiang Fang, J. H. Pixley, Justin H. Wilson

Faculty Publications

Twisting van der Waals heterostructures to induce correlated many body states provides a novel tuning mechanism in solid state physics. In this work, we theoretically investigate the fate of the surface Dirac cone of a three-dimensional topological insulator subject to a superlattice potential. Using a combination of diagrammatic perturbation theory, lattice model simulations, and ab initio calculations we elucidate the unique aspects of twisting a single Dirac cone with an induced moiré potential and the role of the bulk topology on the reconstructed surface band structure. We report a dramatic renormalization of the surface Dirac cone velocity as well as …

Rev-Erb In Gabaergic Neurons Controls Diurnal Hepatic Insulin Sensitivity, Guolian Ding, Xin Li, Xinguo Hou, Wenjun Zhou, Yingyun Gong, Fuqiang Liu, Yanlin He, Jia Song, Jing Wang, Paul Basil, Wenbo Li, Sichong Qian, Pradip Saha, Jinbang Wang, Chen Cui, Tingting Yang, Kexin Zou, Younghun Han, Christopher I. Amos, Yong Xu, Li Chen, Zheng Sun

Division of Basic Science Faculty Publications

Systemic insulin sensitivity shows a diurnal rhythm with a peak upon waking1,2. The molecular mechanism that underlies this temporal pattern is unclear. Here we show that the nuclear receptors REV-ERB-α and REV-ERB-β (referred to here as ‘REV-ERB’) in the GABAergic (γ-aminobutyric acid-producing) neurons in the suprachiasmatic nucleus (SCN) (SCNGABA neurons) control the diurnal rhythm of insulin-mediated suppression of hepatic glucose production in mice, without affecting diurnal eating or locomotor behaviours during regular light–dark cycles. REV-ERB regulates the rhythmic expression of genes that are involved in neurotransmission in the SCN, and modulates the oscillatory firing activity of SCNGABA neurons. Chemogenetic stimulation …

Author Correction: Dense Sampling Of Bird Diversity Increases Power Of Comparative Genomics (Nature, (2020), 587, 7833, (252-257), 10.1038/S41586-020-2873-9), Shaohong Feng, Josefin Stiller, Yuan Deng, Joel Armstrong, Qi Fang, Andrew Hart Reeve, Duo Xie, Guangji Chen, Chunxue Guo, Brant C. Faircloth, Bent Petersen, Zongji Wang, Qi Zhou, Mark Diekhans, Wanjun Chen, Sergio Andreu-Sánchez, Ashot Margaryan, Jason Travis Howard, Carole Parent, George Pacheco, Mikkel Holger S. Sinding, Lara Puetz, Emily Cavill, Ângela M. Ribeiro, Leopold Eckhart, Jon Fjeldså, Peter A. Hosner, Robb T. Brumfield, Les Christidis, Mads F. Bertelsen, Thomas Sicheritz-Ponten, Dieter Thomas Tietze, Bruce C. Robertson

Faculty Publications

In Supplementary Table 1 of this Article, 23 samples (B10K-DU-029-32, B10K-DU-029-33, B10K-DU-029-36 to B10K-DU-029-44, B10K-DU- 029-46, B10K-DU-029-47, B10K-DU-029-49 to B10K-DU-029-53, B10K-DU- 029-75 to B10K-DU-029-77, B10K-DU-029-80, and B10K-DU-030-03; styled in boldface in the revised table) were assigned to the incorrect institution. Supplementary Table 1 has been amended to reflect the correct source institution for these samples, and associated data (tissue, museum ID/source specimen ID, site, state/province, latitude, longitude, date collected and sex) have been updated accordingly. The original table is provided as Supplementary Information to this Amendment, and the original Article has been corrected online.

Mental Imagery In Fear Extinction: A Multi-Component Examination Based On Behavioral, Physiological, And Neurological Measures, Xinrui Jiang

LSU Doctoral Dissertations

Imagery has long been utilized in clinical treatments of affective symptoms with the assumption that mental imagery can stand in for its perceptual counterpart and exert regulatory effects over emotional responses. While this assumption has its ground in theoretical framework of mental imagery supported by evidence of neurological overlaps between imagery and perception, and clinical applications of imagery interventions were found to be successful, very little has been done through means of experimental examinations.

This investigation began with a differential fear conditioning study (study 1) to simulate and assess imagery extinction. Results provided support for the efficacy of imagery exposure …

Effects Of Planning And Repeated Writing Interventions On Writing Fluency, Katherine Lea Moore

LSU Doctoral Dissertations

Writing is an essential skill for academic success. Evidence shows students with writing difficulties experience lower overall academic performance (Graham & Perin, 2007). The development of fluent writing is particularly important, as it has been shown to be a strong predictor of global writing quality (Malecki & Jewell, 2003). Limited research exists on writing interventions specifically targeting writing fluency. While performance feedback procedures have been found effective for increasing writing fluency (Hier & Eckert, 2016), interventions such as story-mapping and self-regulation strategy development (SRSD), which target higher order writing skills, have also been shown to improve writing fluency abilities (Harris, …

The Modern Plant Breeding Triangle: Optimizing The Use Of Genomics, Phenomics, And Enviromics Data, Jose Crossa, Roberto Fritsche-Neto, Osval A. Montesinos-Lopez, Germano Costa-Neto, Susanne Dreisigacker, Abelardo Montesinos-Lopez, Alison R. Bentley

Faculty Publications

No abstract provided.

Laser Power Stabilization Via Radiation Pressure, Marina Trad Nery, Jasper R. Venneberg, Nancy Aggarwal, Garrett D. Cole, Thomas Corbitt, Jonathan Cripe, Robert Lanza, Benno Willke

Faculty Publications

This Letter reports the experimental realization of a novel, to the best of our knowledge, active power stabilization scheme in which laser power fluctuations are sensed via the radiation pressure driven motion they induce on a movable mirror. The mirror position and its fluctuations were determined by means of a weak auxiliary laser beam and a Michelson interferometer, which formed the in-loop sensor of the power stabilization feedback control system. This sensing technique exploits a nondemolition measurement, which can result in higher sensitivity for power fluctuations than direct, and hence destructive, detection. Here we used this new scheme in a …

A Theoretical Calculation Of Stacking Fault Energy Of Ni Alloys: The Effects Of Temperature And Composition, Mohammad S. Dodaran, Shengmin Guo, Michael M. Khonsari, Nima Shamsaei, Shuai Shao

Faculty Publications

Combining cluster expansion (CE) method with one dimensional axial Ising model, this work investigated the effects of alloying elements and configurational variations due to temperature on the stacking fault energy (SFE) of FCC Ni binary alloys. Ensembles of large numbers of atomistic structures, each with more than ~400 atoms, were generated to consider sufficient long-range chemical disorder and temperature effects due to configurational entropy. A Monte Carlo Metropolis algorithm was used to generate these structures, whose energies were then evaluated based on the effective cluster interactions obtained from CE. As a baseline, this work had shown the SFE of pure …

High Temperature Polymer Electrolytes For Hydrogen Fuel Cells And Electrochemical Pumps, Gokul Venugopalan

LSU Doctoral Dissertations

Hydrogen fuel cell and separation technologies such as proton exchange membrane fuel cells (PEMFCs) and electrochemical hydrogen pump (ECHP) offer a profound advantage in the transition to a low-carbon economy. An imperative hitch in hydrogen fuel cells and ECHP technology has been the electrocatalyst poisoning by carbon monoxide (CO) and other contaminants in the reactant mixture. By operating, hydrogen fuel cells and ECHPs at high temperatures (>200 °C), the effect of CO adsorption on the electrocatalyst surface could be curtailed. The high-temperature operation of devices necessitates a proton exchange membrane (PEM) to operate under anhydrous conditions.

In this work, …

A Genetic Screen Identifies New Steps In Oocyte Maturation That Enhance Proteostasis In The Immortal Germ Lineage, M Samaddar, J Goudeau, M Sanchez, D H. Hall, M Samaddar, M Ingaramo, C Kenyon

Faculty Publications

Somatic cells age and die, but the germ-cell lineage is immortal. In Caenorhabditis elegans, germline immortality involves proteostasis renewal at the beginning of each new generation, when oocyte maturation signals from sperm trigger the clearance of carbonylated proteins and protein aggregates. Here, we explore the cell biology of this proteostasis renewal in the context of a whole-genome RNAi screen. Oocyte maturation signals are known to trigger protein-aggregate removal via lysosome acidification. Our findings suggest that lysosomes are acidified as a consequence of changes in endoplasmic reticulum activity that permit assembly of the lysosomal V-ATPase, which in turn allows lysosomes to …

Structure-Activity Relationship Analysis Of Psychedelics In A Rat Model Of Asthma Reveals The Anti-Inflammatory Pharmacophore, Thomas W. Flanagan, Gerald B. Billac, Alexus N. Landry, Melaine N. Sebastian, Stephania A. Cormier, Charles D. Nichols

Division of Basic Science Faculty Publications

Psychedelic drugs can exert potent anti-inflammatory effects. However, anti-inflammatory effects do not appear to correlate with behavioral activity, suggesting different underlying mechanisms. We hypothesized that the distinct structural features of psychedelics underlie functionally selective mechanisms at the target 5-HT2A receptor to elicit maximal anti-inflammatory effects. In order to test this hypothesis, we developed a new rat-based screening platform for allergic asthma. Next, we investigated 21 agonists at the 5-HT2A receptor from the three primary chemotypes (phenylalkylamine, ergoline, and tryptamine) for their ability to prevent airways hyperresponsiveness as a measure of pulmonary inflammation. Furthermore, we assessed each drug for in vitro …

Anesthetic Combination Of Alfaxalone, Dexmedetomidine And Hydromorphone For Comparison Of Endoscopy-Guided Intubation And Blind Orotracheal Intubation In Domestic Rabbits (Oryctolagus Cuniculus), Stephanie Reabel

LSU Master's Theses

Domestic rabbits have a high risk of anesthesia-related mortality compared to other companion animals. Factors that may contribute to increased mortality include drug-induced cardiopulmonary effects (Grint & Murison 2008; Navarrete-Calvo et al. 2013), difficulty performing intubation (Aeschbacher 1995; Flecknell 2016; Wenger et al. 2017) or damage to laryngeal and tracheal tissues following orotracheal intubation (Grint et al. 2006; Phaneuf et al. 2006; Engbers et al. 2017).

Alfaxalone is a neuroactive steroid that produces induction of anesthesia and cardiorespiratory depression in a dose-dependent manner when injected intravenously. The ability to induce anesthesia via an intramuscular (IM) route has several advantages in …

Effects Of Historical Land-Use Change On Surface Runoff And Flooding In The Amite River Basin, Louisiana, Usa Using Coupled 1d/2d Hec-Ras–Hec-Hms Hydrological Modeling, Alexandre G. H. Cowles

LSU Master's Theses

The Amite River Basin is a largely rural watershed spanning parts of four counties in southern Mississippi and seven parishes in southeast Louisiana, with basinwide imperviousness increasing from 0.82% in 1938 to 3.85% in 2016. The Basin has been the subject of significant research interest since catastrophic flooding in 2016 caused 13 deaths and widespread damages. Rapid development in recent decades has led to an expansion of impervious surfaces in Baton Rouge and surrounding areas, encroaching on floodplains and wetlands. At the basin scale, differences in flooding due to impervious cover changes were found to be somewhat limited, particularly along …

Coilin Expression During Nucleolar Stress In The Drosophila Brain, Kathryn Rose Deleo

LSU Master's Theses

Impairment of ribosome biogenesis disrupts cellular homeostasis and, in the process, causes a state of nucleolar stress in a cell. This triggers human syndromes collectively known as ribosomopathies. One such ribosomopathy is the Treacher Collins syndrome (TCS) which causes congenital craniofacial birth defects and hearing loss in patients. In TCS migration of neural crest cells during development is hindered by the loss of the ribosome assembly factor, treacle, and consequent apoptosis of these progenitor cells. Modeling this disorder in Drosophila was previously accomplished by disruption of Nopp140, treacle’s closest equivalent in Drosophila. During nucleolar stress, the Mushroom Body neuroblast …

Dynamic Energy Budget Modelling To Predict Eastern Oyster Growth, Reproduction, And Mortality Under River Management And Climate Change Scenarios, Romain Lavaud, Megan K. La Peyre, Dubravko Justic, Jerome F. La Peyre

Faculty Publications

Eastern oysters growing in deltaic Louisiana estuaries in the northern Gulf of Mexico must tolerate considerable salinity variation from natural climate variability (e.g., rainfall and stream run-off pushing isohalines offshore; tropical storms pushing isohalines inshore) and man-made diversions and siphons releasing freshwater from the Mississippi River. These salinity variations are predicted to increase with future climate change because of the increased frequency of stronger storms and also in response to proposed large-scale river diversions. Increased Mississippi River flow into coastal estuaries from river diversions, along with potential changes in rainfall and stream run-off from climate change will alter spatial and …

Integration And Analysis Of Gaze Behavior In Augmented Reality, George Villaume

Honors Capstones

No abstract provided.

Franz Delitzsch, The Jewish Jesus, And The Pattern Of History: A Nineteenth-Century Dialogue About Christians And Jews In Germany, Shelby Frank Myers

Honors Capstones

No abstract provided.

Plant-Wide Control System Proposal Of Ethylene Cracking Plant Simulation, Estelle Seghers

Honors Capstones

No abstract provided.

Tombs Or Sanctuaries: Convent-Coded Spaces In Middlemarch And Villette, Rachel Mipro

Honors Capstones

No abstract provided.

Expression And Purification Of Mitochondrial Group 3 Lea Protein, Afrlea3m_29, From Diapause Embryos Of Artemia Franciscana, Ivan Dinh Nguyen

Honors Capstones

No abstract provided.