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Deep Underground Neutrino Experiment (Dune) Near Detector Conceptual Design Report, A. Abed Abud, B. Abi, R. Acciarri, M. A. Acero, G. Adamov, D. Adams, M. Adinolfi, A. Aduszkiewicz, Z. Ahmad, J. Ahmed, T. Alion, S. Alonso Monsalve, M. Alrashed, C. Alt, A. Alton, P. Amedo, J. Anderson, C. Andreopoulos, M. P. Andrews, F. Andrianala, S. Andringa, N. Anfimov, A. Ankowski, M. Antonova, S. Antusch, A. Aranda-Fernandez, A. Ariga, L. O. Arnold, M. A. Arroyave, J. Asaadi, A. Aurisano, V. Aushev, D. Autiero Dec 2021

Deep Underground Neutrino Experiment (Dune) Near Detector Conceptual Design Report, A. Abed Abud, B. Abi, R. Acciarri, M. A. Acero, G. Adamov, D. Adams, M. Adinolfi, A. Aduszkiewicz, Z. Ahmad, J. Ahmed, T. Alion, S. Alonso Monsalve, M. Alrashed, C. Alt, A. Alton, P. Amedo, J. Anderson, C. Andreopoulos, M. P. Andrews, F. Andrianala, S. Andringa, N. Anfimov, A. Ankowski, M. Antonova, S. Antusch, A. Aranda-Fernandez, A. Ariga, L. O. Arnold, M. A. Arroyave, J. Asaadi, A. Aurisano, V. Aushev, D. Autiero

Faculty Publications

The Deep Underground Neutrino Experiment (DUNE) is an international, world-class experiment aimed at exploring fundamental questions about the universe that are at the forefront of astrophysics and particle physics research. DUNE will study questions pertaining to the preponderance of matter over antimatter in the early universe, the dynamics of supernovae, the subtleties of neutrino interaction physics, and a number of beyond the Standard Model topics accessible in a powerful neutrino beam. A critical component of the DUNE physics program involves the study of changes in a powerful beam of neutrinos, i.e., neutrino oscillations, as the neutrinos propagate a long distance. …

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Rare Regions And Avoided Quantum Criticality In Disordered Weyl Semimetals And Superconductors, J. H. Pixley, Justin H. Wilson Dec 2021

Rare Regions And Avoided Quantum Criticality In Disordered Weyl Semimetals And Superconductors, J. H. Pixley, Justin H. Wilson

Faculty Publications

Disorder in Weyl semimetals and superconductors is surprisingly subtle, attracting attention and competing theories in recent years. In this brief review, we discuss the current theoretical understanding of the effects of short-ranged, quenched disorder on the low energy-properties of three-dimensional, topological Weyl semimetals and superconductors. We focus on the role of non-perturbative rare region effects on destabilizing the semimetal phase and rounding the expected semimetal-to-diffusive metal transition into a cross over. Furthermore, the consequences of disorder on the resulting nature of excitations, transport, and topology are reviewed. New results on a bipartite random hopping model are presented that confirm previous …

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Management Of Stemborers (Lepidoptera: Crambidae) Using Foliar-Applied Chlorantraniliprole In Rice, James M. Villegas, Blake E. Wilson, Michael O. Way Dec 2021

Management Of Stemborers (Lepidoptera: Crambidae) Using Foliar-Applied Chlorantraniliprole In Rice, James M. Villegas, Blake E. Wilson, Michael O. Way

Faculty Publications

Rice is one of the most important crops in Louisiana and Texas, USA. It is subjected to various insect pests throughout the growing season. Lepidopteran stem-boring pests including the Mexican rice borer, Eoreuma loftini (Dyar) (Lepidoptera: Crambidae), are increasing in economic importance as insect pests in rice production, particularly in southwest Louisiana, USA. Field trials were conducted in Louisiana and Texas to examine the efficacy of foliar-applied insecticides (chlorantraniliprole and the pyrethroids ζ-cypermethrin and λ-cyhalothrin) and chlorantraniliprole seed treatment for control of rice stemborers during 2018 and 2019. Furthermore, a diet incorporation assay assessed the toxicity of chlorantraniliprole to laboratory-reared …

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Whole Genome Comparisons Reveal Panmixia Among Fall Armyworm (Spodoptera Frugiperda) From Diverse Locations, Katrina A. Schlum, Kurt Lamour, Caroline Placidi De Bortoli, Rahul Banerjee, Robert Meagher, Eliseu Pereira, Maria Gabriela Murua, Gregory A. Sword, Ashley E. Tessnow, Diego Viteri Dillon, Angela M. Linares Ramirez, Komivi S. Akutse, Rebecca Schmidt-Jeffris, Fangneng Huang, Dominic Reisig, Scott J. Emrich, Juan Luis Jurat-Fuentes Dec 2021

Whole Genome Comparisons Reveal Panmixia Among Fall Armyworm (Spodoptera Frugiperda) From Diverse Locations, Katrina A. Schlum, Kurt Lamour, Caroline Placidi De Bortoli, Rahul Banerjee, Robert Meagher, Eliseu Pereira, Maria Gabriela Murua, Gregory A. Sword, Ashley E. Tessnow, Diego Viteri Dillon, Angela M. Linares Ramirez, Komivi S. Akutse, Rebecca Schmidt-Jeffris, Fangneng Huang, Dominic Reisig, Scott J. Emrich, Juan Luis Jurat-Fuentes

Faculty Publications

Background: The fall armyworm (Spodoptera frugiperda (J.E. Smith)) is a highly polyphagous agricultural pest with long-distance migratory behavior threatening food security worldwide. This pest has a host range of > 80 plant species, but two host strains are recognized based on their association with corn (C-strain) or rice and smaller grasses (R-strain). The population genomics of the United States (USA) fall armyworm remains poorly characterized to date despite its agricultural threat. Results: In this study, the population structure and genetic diversity in 55 S. frugiperda samples from Argentina, Brazil, Kenya, Puerto Rico and USA were surveyed to further our understanding of …

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Spatial Cluster Detection With Threshold Quantile Regression, Junho Lee, Ying Sun, Huixia Judy Wang Dec 2021

Spatial Cluster Detection With Threshold Quantile Regression, Junho Lee, Ying Sun, Huixia Judy Wang

Faculty Publications

Spatial cluster detection, which is the identification of spatial units adjacent in space associated with distinctive patterns of data of interest relative to background variation, is useful for discerning spatial heterogeneity in regression coefficients. Some real studies with regression-based models on air quality data show that there exists not only spatial heterogeneity but also heteroscedasticity between air pollution and its predictors. Since the low air quality is a well-known risk factor for mortality, various cardiopulmonary diseases, and preterm birth, the analysis at the tail would be of more interest than the center of air pollution distribution. In this article, we …

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Correction To: Deep Mantle Melting, Global Water Circulation And Its Implications For The Stability Of The Ocean Mass (Progress In Earth And Planetary Science, (2020), 7, 1, (76), 10.1186/S40645-020-00379-3), Shun Ichiro Karato, Bijaya Karki, Jeffrey Park Dec 2021

Correction To: Deep Mantle Melting, Global Water Circulation And Its Implications For The Stability Of The Ocean Mass (Progress In Earth And Planetary Science, (2020), 7, 1, (76), 10.1186/S40645-020-00379-3), Shun Ichiro Karato, Bijaya Karki, Jeffrey Park

Faculty Publications

Following publication of the original article (Karato et al., 2020), the author identified there is a minor typo in Fig. 13 and graphical abstract image. The correct Fig. 13 and graphic abstract image are provided below. The original paper has been updated.

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Diving Beneath The Sea Of Stellar Activity: Chromatic Radial Velocities Of The Young Au Mic Planetary System, Bryson Cale, Michael Reefe, Peter Plavchan, Angelle Tanner, Eric Gaidos, Jonathan Gagne, Peter Gao, Stephen R. Kane, Victor J. S. Bejar, Nicolas Lodieu, Guillem Anglada-Escude, Ignasi Ribas, Enric Palle, Andreas Quirrenbach, Pedro Amado, Ansgar Reiners, Jose A. Caballero, Maria Rosa Zapatero Osorio, Stefan Dreizler, Andrew W. Howard, Benjamin J. Fulton, Sharon Xuesong Wang, Kevin I. Collins, Mohammed El Mufti, Justin Wittrock, Emily A. Gilbert, Thomas Barclay, Baptiste Klein, Eder Martioli, Robert Wittenmyer, Duncan Wright, Brett Addison, Teruyuki Hirano, Motohide Tamura, Takayuki Kotani, Norio Narita, David Vermilion, Rena A. Lee, Claire Geneser, Johanna Teske, Samuel N. Quinn, David W. Latham, Gilbert A. Esquerdo, Michael L. Calkins, Perry Berlind, Farzaneh Zohrabi, Caitlin Stibbards, Srihan Kotnana, Jon Jenkins, Joseph D. Twicken, Christopher Henze, Richard Kidwell, Jr., Christopher Burke, Joel Villasenor, Patricia Boyd Dec 2021

Diving Beneath The Sea Of Stellar Activity: Chromatic Radial Velocities Of The Young Au Mic Planetary System, Bryson Cale, Michael Reefe, Peter Plavchan, Angelle Tanner, Eric Gaidos, Jonathan Gagne, Peter Gao, Stephen R. Kane, Victor J. S. Bejar, Nicolas Lodieu, Guillem Anglada-Escude, Ignasi Ribas, Enric Palle, Andreas Quirrenbach, Pedro Amado, Ansgar Reiners, Jose A. Caballero, Maria Rosa Zapatero Osorio, Stefan Dreizler, Andrew W. Howard, Benjamin J. Fulton, Sharon Xuesong Wang, Kevin I. Collins, Mohammed El Mufti, Justin Wittrock, Emily A. Gilbert, Thomas Barclay, Baptiste Klein, Eder Martioli, Robert Wittenmyer, Duncan Wright, Brett Addison, Teruyuki Hirano, Motohide Tamura, Takayuki Kotani, Norio Narita, David Vermilion, Rena A. Lee, Claire Geneser, Johanna Teske, Samuel N. Quinn, David W. Latham, Gilbert A. Esquerdo, Michael L. Calkins, Perry Berlind, Farzaneh Zohrabi, Caitlin Stibbards, Srihan Kotnana, Jon Jenkins, Joseph D. Twicken, Christopher Henze, Richard Kidwell, Jr., Christopher Burke, Joel Villasenor, Patricia Boyd

Faculty Publications

We present updated radial-velocity (RV) analyses of the AU Mic system. AU Mic is a young (22 Myr) early-M dwarf known to host two transiting planets-P-b similar to 8.46 days, R-b = 4.381(-0.18)(+0.18) R-circle plus, P-c similar to 18.86 days, R-c = 3.5(-0.16)(+0.16) R-circle plus. With visible RVs from Calar Alto high-Resolution search for M dwarfs with Exo-earths with Near-infrared and optical echelle Spectrographs (CARMENES)-VIS, CHIRON, HARPS, HIRES, MINERVA-Australis, and Tillinghast Reflector Echelle Spectrograph, as well as near-infrared (NIR) RVs from CARMENES-NIR, CSHELL, IRD, iSHELL, NIRSPEC, and SPIRou, we provide a 5 sigma upper limit to the mass of AU …

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A Multi-Study Examination Of The Role Of Repeated Spaced Retrieval In The Word Learning Of Children With Developmental Language Disorder, Laurence B. Leonard, Sharon L. Christ, Patricia Deevy, Jeffrey D. Karpicke, Christine Weber, Eileen Haebig, Justin B. Kueser, Sofía Souto, Windi Krok Dec 2021

A Multi-Study Examination Of The Role Of Repeated Spaced Retrieval In The Word Learning Of Children With Developmental Language Disorder, Laurence B. Leonard, Sharon L. Christ, Patricia Deevy, Jeffrey D. Karpicke, Christine Weber, Eileen Haebig, Justin B. Kueser, Sofía Souto, Windi Krok

Faculty Publications

Background: Many children with developmental language disorders (DLD) have well-documented weaknesses in vocabulary. In recent years, investigators have explored the nature of these weaknesses through the use of novel word learning paradigms. These studies have begun to uncover specific areas of difficulty and have provided hints about possible intervention strategies that might help these children learn words more accurately and efficiently. Among the studies of this type are those that incorporate repeated spaced retrieval activities in the learning procedures. Methods: In this study, we examined the data from four of these studies that employed the same types of participants (4- …

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Author Correction: Twelve-Month Specific Igg Response To Sars-Cov-2 Receptor-Binding Domain Among Covid-19 Convalescent Plasma Donors In Wuhan (Nature Communications, (2021), 12, 1, (4144), 10.1038/S41467-021-24230-5), Cesheng Li, Ding Yu, Xiao Wu, Hong Liang, Zhijun Zhou, Yong Xie, Taojing Li, Junzheng Wu, Fengping Lu, Lu Feng, Min Mao, Lianzhen Lin, Huanhuan Guo, Shenglan Yue, Feifei Wang, Yan Peng, Yong Hu, Zejun Wang, Jianhong Yu, Yong Zhang, Jia Lu, Haoran Ning, Huichuan Yang, Daoxing Fu, Yanlin He, Dongbo Zhou, Tao Du, Kai Duan, Demei Dong, Kun Deng, Xia Zou, Ya Zhang, Rong Zhou, Yang Gao Dec 2021

Author Correction: Twelve-Month Specific Igg Response To Sars-Cov-2 Receptor-Binding Domain Among Covid-19 Convalescent Plasma Donors In Wuhan (Nature Communications, (2021), 12, 1, (4144), 10.1038/S41467-021-24230-5), Cesheng Li, Ding Yu, Xiao Wu, Hong Liang, Zhijun Zhou, Yong Xie, Taojing Li, Junzheng Wu, Fengping Lu, Lu Feng, Min Mao, Lianzhen Lin, Huanhuan Guo, Shenglan Yue, Feifei Wang, Yan Peng, Yong Hu, Zejun Wang, Jianhong Yu, Yong Zhang, Jia Lu, Haoran Ning, Huichuan Yang, Daoxing Fu, Yanlin He, Dongbo Zhou, Tao Du, Kai Duan, Demei Dong, Kun Deng, Xia Zou, Ya Zhang, Rong Zhou, Yang Gao

Division of Basic Science Faculty Publications

The original version of this Article contained an error in the abstract, which incorrectly read ‘The level of RBD-IgG decreases with time, with the titer stabilizing at 64.3% of the initial level by 9 month’. The correct version replaces this sentence with ‘The level of RBD-IgG decreases with time, with the titer stabilizing at 35.7% of the initial level by the 9th month’. This has been corrected in both the PDF and HTML versions of the Article.

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Deciphering An Agrp-Serotoninergic Neural Circuit In Distinct Control Of Energy Metabolism From Feeding, Yong Han, Guobin Xia, Dollada Srisai, Fantao Meng, Yanlin He, Yali Ran, Yang He, Monica Farias, Giang Hoang, István Tóth, Marcelo O. Dietrich, Miao Hsueh Chen, Yong Xu, Qi Wu Dec 2021

Deciphering An Agrp-Serotoninergic Neural Circuit In Distinct Control Of Energy Metabolism From Feeding, Yong Han, Guobin Xia, Dollada Srisai, Fantao Meng, Yanlin He, Yali Ran, Yang He, Monica Farias, Giang Hoang, István Tóth, Marcelo O. Dietrich, Miao Hsueh Chen, Yong Xu, Qi Wu

Division of Basic Science Faculty Publications

Contrasting to the established role of the hypothalamic agouti-related protein (AgRP) neurons in feeding regulation, the neural circuit and signaling mechanisms by which they control energy expenditure remains unclear. Here, we report that energy expenditure is regulated by a subgroup of AgRP neurons that send non-collateral projections to neurons within the dorsal lateral part of dorsal raphe nucleus (dlDRN) expressing the melanocortin 4 receptor (MC4R), which in turn innervate nearby serotonergic (5-HT) neurons. Genetic manipulations reveal a bi-directional control of energy expenditure by this circuit without affecting food intake. Fiber photometry and electrophysiological results indicate that the thermo-sensing MC4RdlDRN neurons …

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A Randomized Clinical Trial On The Effects Of Exercise On Muscle Remodelling Following Bariatric Surgery, Saulo Gil, John P. Kirwan, Igor H. Murai, Wagner S. Dantas, Carlos Alberto Abujabra Merege-Filho, Sujoy Ghosh, Samuel K. Shinjo, Rosa M.R. Pereira, Walcy R. Teodoro, Sheylla M. Felau, Fabiana B. Benatti, Ana L. De Sá-Pinto, Fernanda Lima, Roberto De Cleva, Marco Aurélio Santo, Bruno Gualano, Hamilton Roschel Dec 2021

A Randomized Clinical Trial On The Effects Of Exercise On Muscle Remodelling Following Bariatric Surgery, Saulo Gil, John P. Kirwan, Igor H. Murai, Wagner S. Dantas, Carlos Alberto Abujabra Merege-Filho, Sujoy Ghosh, Samuel K. Shinjo, Rosa M.R. Pereira, Walcy R. Teodoro, Sheylla M. Felau, Fabiana B. Benatti, Ana L. De Sá-Pinto, Fernanda Lima, Roberto De Cleva, Marco Aurélio Santo, Bruno Gualano, Hamilton Roschel

Division of Basic Science Faculty Publications

Background: Muscle atrophy and strength loss are common adverse outcomes following bariatric surgery. This randomized, controlled trial investigated the effects of exercise training on bariatric surgery-induced loss of muscle mass and function. Additionally, we investigated the effects of the intervention on molecular and histological mediators of muscle remodelling. Methods: Eighty women with obesity were randomly assigned to a Roux-en-Y gastric bypass (RYGB: n = 40, age = 42 ± 8 years) or RYGB plus exercise training group (RYGB + ET: n = 40, age = 38 ± 7 years). Clinical and laboratory parameters were assessed at baseline, and 3 (POST3) …

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Impact Of Acute Exercise On Peripheral Blood Mononuclear Cells Nutrient Sensing And Mitochondrial Oxidative Capacity In Healthy Young Adults, Bailey Theall, James Stampley, Eunhan Cho, Joshua Granger, Neil M. Johannsen, Brian A. Irving, Guillaume Spielmann Dec 2021

Impact Of Acute Exercise On Peripheral Blood Mononuclear Cells Nutrient Sensing And Mitochondrial Oxidative Capacity In Healthy Young Adults, Bailey Theall, James Stampley, Eunhan Cho, Joshua Granger, Neil M. Johannsen, Brian A. Irving, Guillaume Spielmann

Clinical Research Faculty Publications

Regular exercise is associated with changes in peripheral blood mononuclear cell (PBMC) proportions that have enhanced effector functions in young and old adults; however, the effects of acute exercise on PBMC nutrient sensors and metabolic function in active young adults is unknown. To fill this gap, activation status and nutrient-sensing mechanisms of PBMCs isolated from 21 healthy active adults (20–35 yr; 36.5 ± 6.3 V̇O2peak) were characterized before and after 30 min of moderate-to-vigorous cycling (65%–75% V̇O2peak). In addition, changes in PBMC mitochondrial respiratory function in response to exercise were assessed using high-resolution respirometry. There was an increase in the …

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Ncaa Division I American Football Players With Sickle Cell Trait Have Altered Hematological Responses And Hydration Status, Haoyan Wang, Matt Martone, Michael E. Owens, Nathan P. Lemoine, Jack Marucci, Derek Calvert, Shelly Mullenix, Timothy S. Church, Jennifer Rood, Brian Harrell, Brian A. Irving, Guillaume Spielmann, Neil M. Johannsen Dec 2021

Ncaa Division I American Football Players With Sickle Cell Trait Have Altered Hematological Responses And Hydration Status, Haoyan Wang, Matt Martone, Michael E. Owens, Nathan P. Lemoine, Jack Marucci, Derek Calvert, Shelly Mullenix, Timothy S. Church, Jennifer Rood, Brian Harrell, Brian A. Irving, Guillaume Spielmann, Neil M. Johannsen

Clinical Research Faculty Publications

Sickle cell trait (SCT) is a risk factor of collapse and sudden death in athletes. We conducted a longitudinal study to determine the hematological responses and hydration status in NCAA Division I American football players with SCT. The study took place over 2 years with 6 SCT and 6 position-matched controls (CON) in year 1; and 4 SCT and 4 CON in year 2. In year 2, three of the four SCT players were recruited and re-enrolled with new position-matched controls (total sample data = 10 SCT and 10 CON). Blood samples were taken at three visits: pre-camp, post-camp, and …

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The Acute Transcriptional Responses To Dietary Methionine Restriction Are Triggered By Inhibition Of Ternary Complex Formation And Linked To Erk1/2, Mtor, And Atf4, Kirsten P. Stone, Sujoy Ghosh, Jean Paul Kovalik, Manda Orgeron, Desiree Wanders, Landon C. Sims, Thomas W. Gettys Dec 2021

The Acute Transcriptional Responses To Dietary Methionine Restriction Are Triggered By Inhibition Of Ternary Complex Formation And Linked To Erk1/2, Mtor, And Atf4, Kirsten P. Stone, Sujoy Ghosh, Jean Paul Kovalik, Manda Orgeron, Desiree Wanders, Landon C. Sims, Thomas W. Gettys

Division of Basic Science Faculty Publications

The initial sensing of dietary methionine restriction (MR) occurs in the liver where it activates an integrated stress response (ISR) that quickly reduces methionine utilization. The ISR program is regulated in part by ATF4, but ATF4’s prototypical upstream regulator, eIF2α, is not acutely activated by MR. Bioinformatic analysis of RNAseq and metabolomics data from liver samples harvested 3 h and 6 h after initiating MR shows that general translation is inhibited at the level of ternary complex formation by an acute 50% reduction of hepatic methionine that limits formation of initiator methionine tRNA. The resulting ISR is induced by selective …

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Nt-Pgc-1Α Deficiency Attenuates High-Fat Diet-Induced Obesity By Modulating Food Intake, Fecal Fat Excretion And Intestinal Fat Absorption, Jihyun Kim, Jiyoung Moon, Chul Hong Park, Jisu Lee, Helia Cheng, Z. Elizabeth Floyd, Ji Suk Chang Dec 2021

Nt-Pgc-1Α Deficiency Attenuates High-Fat Diet-Induced Obesity By Modulating Food Intake, Fecal Fat Excretion And Intestinal Fat Absorption, Jihyun Kim, Jiyoung Moon, Chul Hong Park, Jisu Lee, Helia Cheng, Z. Elizabeth Floyd, Ji Suk Chang

Division of Basic Science Faculty Publications

Transcriptional coactivator PGC-1α and its splice variant NT-PGC-1α regulate metabolic adaptation by modulating many gene programs. Selective ablation of PGC-1α attenuates diet-induced obesity through enhancing fatty acid oxidation and thermogenesis by upregulation of NT-PGC-1α in brown adipose tissue (BAT). Recently, we have shown that selective ablation of NT-PGC-1α reduces fatty acid oxidation in BAT. Thus, the objective of this study was to test our hypothesis that NT-PGC-1α−/− mice would be more prone to diet-induced obesity. Male and female NT-PGC-1α+/+ (WT) and NT-PGC-1α−/− mice were fed a regular chow or 60% high-fat (HF) diet for 16 weeks. Contrary to our expectations, …

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Association Between Particulate Matter Containing Epfrs And Neutrophilic Asthma Through Ahr And Th17, Jeffrey N. Harding, Maureen Gross, Vivek Patel, Steven Potter, Stephania A. Cormier Dec 2021

Association Between Particulate Matter Containing Epfrs And Neutrophilic Asthma Through Ahr And Th17, Jeffrey N. Harding, Maureen Gross, Vivek Patel, Steven Potter, Stephania A. Cormier

Division of Basic Science Faculty Publications

Background: Epidemiological data associate high levels of combustion-derived particulate matter (PM) with deleterious respiratory outcomes, but the mechanism underlying those outcomes remains elusive. It has been acknowledged by the World Health Organization that PM exposure contributes to more than 4.2 million all-cause mortalities worldwide each year. Current literature demonstrates that PM exacerbates respiratory diseases, impairs lung function, results in chronic respiratory illnesses, and is associated with increased mortality. The proposed mechanisms revolve around oxidative stress and inflammation promoting pulmonary physiological remodeling. However, our previous data found that PM is capable of inducing T helper cell 17 (Th17) immune responses via …

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Author Correction: Spread Of Pathological Tau Proteins Through Communicating Neurons In Human Alzheimer’S Disease (Nature Communications, (2020), 11, 1, (2612), 10.1038/S41467-020-15701-2), Jacob W. Vogel, Yasser Iturria-Medina, Olof T. Strandberg, Ruben Smith, Elizabeth Levitis, Alan C. Evans, Oskar Hansson, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles Decarli Dec 2021

Author Correction: Spread Of Pathological Tau Proteins Through Communicating Neurons In Human Alzheimer’S Disease (Nature Communications, (2020), 11, 1, (2612), 10.1038/S41467-020-15701-2), Jacob W. Vogel, Yasser Iturria-Medina, Olof T. Strandberg, Ruben Smith, Elizabeth Levitis, Alan C. Evans, Oskar Hansson, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles Decarli

Clinical Research Faculty Publications

The original version of the Supplementary information associated with this Article inadvertently omitted Supplementary Table S1. The HTML has been updated to include a corrected version of the Supplementary information.

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Correlation Between Alzheimer’S Disease And Type 2 Diabetes Using Non-Negative Matrix Factorization, Yeonwoo Chung, Hyunju Lee, Michael W. Weiner, Paul Aisen, Ronald Petersen, Cliford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, Davie Holtzman, M. Marcel Mesulam, William Potter, Peter Snyder, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Tamie Sather, Gus Jiminez, Archana B. Balasubramanian Dec 2021

Correlation Between Alzheimer’S Disease And Type 2 Diabetes Using Non-Negative Matrix Factorization, Yeonwoo Chung, Hyunju Lee, Michael W. Weiner, Paul Aisen, Ronald Petersen, Cliford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, Davie Holtzman, M. Marcel Mesulam, William Potter, Peter Snyder, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Tamie Sather, Gus Jiminez, Archana B. Balasubramanian

Clinical Research Faculty Publications

Alzheimer’s disease (AD) is a complex and heterogeneous disease that can be affected by various genetic factors. Although the cause of AD is not yet known and there is no treatment to cure this disease, its progression can be delayed. AD has recently been recognized as a brain-specific type of diabetes called type 3 diabetes. Several studies have shown that people with type 2 diabetes (T2D) have a higher risk of developing AD. Therefore, it is important to identify subgroups of patients with AD that may be more likely to be associated with T2D. We here describe a new approach …

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Accelerated Functional Brain Aging In Pre-Clinical Familial Alzheimer’S Disease, Julie Gonneaud, Alex T. Baria, Alexa Pichet Binette, Brian A. Gordon, Jasmeer P. Chhatwal, Carlos Cruchaga, Mathias Jucker, Johannes Levin, Stephen Salloway, Martin Farlow, Martin Farlow, Serge Gauthier, Tammie L.S. Benzinger, John C. Morris, Randall J. Bateman, John C.S. Breitner, Judes Poirier, Etienne Vachon-Presseau, Sylvia Villeneuve, Michael Weiner, Howard J. Rosen, Bruce L. Miller, Paul Aisen, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Ronald Petersen, Clifford R. Jack, Matthew Bernstein, Bret Borowski, Jeff Gunter Dec 2021

Accelerated Functional Brain Aging In Pre-Clinical Familial Alzheimer’S Disease, Julie Gonneaud, Alex T. Baria, Alexa Pichet Binette, Brian A. Gordon, Jasmeer P. Chhatwal, Carlos Cruchaga, Mathias Jucker, Johannes Levin, Stephen Salloway, Martin Farlow, Martin Farlow, Serge Gauthier, Tammie L.S. Benzinger, John C. Morris, Randall J. Bateman, John C.S. Breitner, Judes Poirier, Etienne Vachon-Presseau, Sylvia Villeneuve, Michael Weiner, Howard J. Rosen, Bruce L. Miller, Paul Aisen, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Ronald Petersen, Clifford R. Jack, Matthew Bernstein, Bret Borowski, Jeff Gunter

Clinical Research Faculty Publications

Resting state functional connectivity (rs-fMRI) is impaired early in persons who subsequently develop Alzheimer’s disease (AD) dementia. This impairment may be leveraged to aid investigation of the pre-clinical phase of AD. We developed a model that predicts brain age from resting state (rs)-fMRI data, and assessed whether genetic determinants of AD, as well as beta-amyloid (Aβ) pathology, can accelerate brain aging. Using data from 1340 cognitively unimpaired participants between 18–94 years of age from multiple sites, we showed that topological properties of graphs constructed from rs-fMRI can predict chronological age across the lifespan. Application of our predictive model to the …

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A Deep Learning Framework Identifies Dimensional Representations Of Alzheimer’S Disease From Brain Structure, Zhijian Yang, Ilya M. Nasrallah, Haochang Shou, Junhao Wen, Jimit Doshi, Mohamad Habes, Guray Erus, Ahmed Abdulkadir, Susan M. Resnick, Marilyn S. Albert, Paul Maruff, Jurgen Fripp, John C. Morris, David A. Wolk, Christos Davatzikos, Yong Fan, Vishnu Bashyam, Elizabeth Mamouiran, Randa Melhem, Raymond Pomponio, Dushyant Sahoo, Singh Ashish, Ioanna Skampardoni, Lasya Sreepada, Dhivya Srinivasan, Fanyang Yu, Sindhuja Govindarajan Tirumalai, Yuhan Cui, Zhen Zhou, Katharina Wittfeld, Hans J. Grabe, Duygun Tosun, Murat Bilgel, Yang An Dec 2021

A Deep Learning Framework Identifies Dimensional Representations Of Alzheimer’S Disease From Brain Structure, Zhijian Yang, Ilya M. Nasrallah, Haochang Shou, Junhao Wen, Jimit Doshi, Mohamad Habes, Guray Erus, Ahmed Abdulkadir, Susan M. Resnick, Marilyn S. Albert, Paul Maruff, Jurgen Fripp, John C. Morris, David A. Wolk, Christos Davatzikos, Yong Fan, Vishnu Bashyam, Elizabeth Mamouiran, Randa Melhem, Raymond Pomponio, Dushyant Sahoo, Singh Ashish, Ioanna Skampardoni, Lasya Sreepada, Dhivya Srinivasan, Fanyang Yu, Sindhuja Govindarajan Tirumalai, Yuhan Cui, Zhen Zhou, Katharina Wittfeld, Hans J. Grabe, Duygun Tosun, Murat Bilgel, Yang An

Clinical Research Faculty Publications

Heterogeneity of brain diseases is a challenge for precision diagnosis/prognosis. We describe and validate Smile-GAN (SeMI-supervised cLustEring-Generative Adversarial Network), a semi-supervised deep-clustering method, which examines neuroanatomical heterogeneity contrasted against normal brain structure, to identify disease subtypes through neuroimaging signatures. When applied to regional volumes derived from T1-weighted MRI (two studies; 2,832 participants; 8,146 scans) including cognitively normal individuals and those with cognitive impairment and dementia, Smile-GAN identified four patterns or axes of neurodegeneration. Applying this framework to longitudinal data revealed two distinct progression pathways. Measures of expression of these patterns predicted the pathway and rate of future neurodegeneration. Pattern expression …

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Global Effect Of Covid-19 Pandemic On Physical Activity, Sedentary Behaviour And Sleep Among 3- To 5-Year-Old Children: A Longitudinal Study Of 14 Countries, Anthony D. Okely, Katharina E. Kariippanon, Hongyan Guan, Ellie K. Taylor, Thomas Suesse, Penny L. Cross, Kar Hau Chong, Adang Suherman, Ali Turab, Amanda E. Staiano, Amy S. Ha, Asmaa El Hamdouchi, Aqsa Baig, Bee Koon Poh, Borja Del Pozo-Cruz, Cecilia H.S. Chan, Christine Delisle Nyström, Denise Koh, E. Kipling Webster, Himangi Lubree, Hong Kim Tang, Issad Baddou, Jesus Del Pozo-Cruz, Jyh Eiin Wong, Kuston Sultoni, Maria Nacher, Marie Löf, Mingming Cui, Mohammad Sorowar Hossain, P. W.Prasad Chathurangana, Uddhavi Kand, V. P.Pujitha Wickramasinghe, Rebecca Calleia, Shameema Ferdous Dec 2021

Global Effect Of Covid-19 Pandemic On Physical Activity, Sedentary Behaviour And Sleep Among 3- To 5-Year-Old Children: A Longitudinal Study Of 14 Countries, Anthony D. Okely, Katharina E. Kariippanon, Hongyan Guan, Ellie K. Taylor, Thomas Suesse, Penny L. Cross, Kar Hau Chong, Adang Suherman, Ali Turab, Amanda E. Staiano, Amy S. Ha, Asmaa El Hamdouchi, Aqsa Baig, Bee Koon Poh, Borja Del Pozo-Cruz, Cecilia H.S. Chan, Christine Delisle Nyström, Denise Koh, E. Kipling Webster, Himangi Lubree, Hong Kim Tang, Issad Baddou, Jesus Del Pozo-Cruz, Jyh Eiin Wong, Kuston Sultoni, Maria Nacher, Marie Löf, Mingming Cui, Mohammad Sorowar Hossain, P. W.Prasad Chathurangana, Uddhavi Kand, V. P.Pujitha Wickramasinghe, Rebecca Calleia, Shameema Ferdous

Population and Public Health Science Faculty Publications

Background: The restrictions associated with the 2020 COVID-19 pandemic has resulted in changes to young children’s daily routines and habits. The impact on their participation in movement behaviours (physical activity, sedentary screen time and sleep) is unknown. This international longitudinal study compared young children’s movement behaviours before and during the COVID-19 pandemic. Methods: Parents of children aged 3–5 years, from 14 countries (8 low- and middle-income countries, LMICs) completed surveys to assess changes in movement behaviours and how these changes were associated with the COVID-19 pandemic. Surveys were completed in the 12 months up to March 2020 and again between …

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Fourteen New, Endemic Species Of Shrew (Genus Crocidura) From Sulawesi Reveal A Spectacular Island Radiation, Jacob A. Esselstyn, Anang S. Achmadi, Heru Handika, Mark T. Swanson, Thomas C. Giarla, Kevin C. Rowe Dec 2021

Fourteen New, Endemic Species Of Shrew (Genus Crocidura) From Sulawesi Reveal A Spectacular Island Radiation, Jacob A. Esselstyn, Anang S. Achmadi, Heru Handika, Mark T. Swanson, Thomas C. Giarla, Kevin C. Rowe

Faculty Publications

After nearly a decade of field inventories in which we preserved voucher specimens of the small terrestrial mammals of Sulawesi, we combined qualitative and quantitative analyses of morphological traits with molecular phylogenetics to better understand the diversity of shrews (Soricidae: Crocidura) on the island. We examined the morphology of 1368 specimens and obtained extensive molecular data from many of them, including mitochondrial DNA sequences from 851 specimens, up to five nuclear exons from 657 specimens, and thousands of ultraconserved elements from 90 specimens. By iteratively testing species limits using distinct character datasets and appropriate taxon sampling, we found clear, mostly …

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Staging Tau Pathology With Tau Pet In Alzheimer’S Disease: A Longitudinal Study, Shi Dong Chen, Jia Ying Lu, Hong Qi Li, Yu Xiang Yang, Jie Hui Jiang, Mei Cui, Chuan Tao Zuo, Lan Tan, Qiang Dong, Jin Tai Yu, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Richard J. Perrin, Leslie M. Shaw, Maria Carrillo, William Potter, Lisa Barnes, Marie Bernard, Hector González, Carole Ho, John K. Hsiao, Jonathan Jackson, Eliezer Masliah, Donna Masterman, Ozioma Okonkwo Dec 2021

Staging Tau Pathology With Tau Pet In Alzheimer’S Disease: A Longitudinal Study, Shi Dong Chen, Jia Ying Lu, Hong Qi Li, Yu Xiang Yang, Jie Hui Jiang, Mei Cui, Chuan Tao Zuo, Lan Tan, Qiang Dong, Jin Tai Yu, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Richard J. Perrin, Leslie M. Shaw, Maria Carrillo, William Potter, Lisa Barnes, Marie Bernard, Hector González, Carole Ho, John K. Hsiao, Jonathan Jackson, Eliezer Masliah, Donna Masterman, Ozioma Okonkwo

Clinical Research Faculty Publications

A biological research framework to define Alzheimer’ disease with dichotomized biomarker measurement was proposed by National Institute on Aging–Alzheimer’s Association (NIA–AA). However, it cannot characterize the hierarchy spreading pattern of tau pathology. To reflect in vivo tau progression using biomarker, we constructed a refined topographic 18F-AV-1451 tau PET staging scheme with longitudinal clinical validation. Seven hundred and thirty-four participants with baseline 18F-AV-1451 tau PET (baseline age 73.9 ± 7.7 years, 375 female) were stratified into five stages by a topographic PET staging scheme. Cognitive trajectories and clinical progression were compared across stages with or without further dichotomy of amyloid status, …

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Experimental Investigation Of The Aerodynamics Of A Large Industrial Building With Parapet, Aly Mousaad Aly, Matthew Thomas, Hamzeh Gol-Zaroudi Dec 2021

Experimental Investigation Of The Aerodynamics Of A Large Industrial Building With Parapet, Aly Mousaad Aly, Matthew Thomas, Hamzeh Gol-Zaroudi

Faculty Publications

The aerodynamic performance of a roof depends significantly on its shape and size, among other factors. For instance, large roofs of industrial low-rise buildings may behave differently compared to those of residential homes. The main objective of this study is to experimentally investigate how perimeter solid parapets can alter the flow pattern around a low-rise building with a large aspect ratio of width/height of about 7.6, the case of industrial buildings/shopping centers. Solid parapets of varied sizes are added to the roof and tested in an open-jet simulator in a comparative study to understand their impact on roof pressure coefficients. …

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Bridge Load Posting Prediction, Sabarethinam Kameshwar, Md. Manik Mia, Sai Bandaru Dec 2021

Bridge Load Posting Prediction, Sabarethinam Kameshwar, Md. Manik Mia, Sai Bandaru

Publications

There are approximately 13,000 bridges in Louisiana facilitating movement of people, goods, and services. At present, about 12% of the bridges are load posted, i.e., they are deemed to lack the strength to safely carry all legal loads. With time bridges will age and deteriorate; at the same time, legal loads might increase. Load posted bridges disrupt the movement of goods and commerce. Therefore, objective of this research was to estimate the number of load posted bridges in Louisiana over the next 50 years. For this purpose, herein, a data based approach was used. For a given bridge type, the …

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Expanding The Concept Of Comprehensive Area Ratio Parameter To The South-Central States: Towards Simplifying The Structural Evaluation Of Flexible Pavements At The Network Level, Mena Souliman, Samer Dessouky, Nitish R. Bastola Dec 2021

Expanding The Concept Of Comprehensive Area Ratio Parameter To The South-Central States: Towards Simplifying The Structural Evaluation Of Flexible Pavements At The Network Level, Mena Souliman, Samer Dessouky, Nitish R. Bastola

Publications

The surface deflection bowl data collected through falling weight deflectometer (FWD) test is utilized by highway agencies in assessing the performance of the flexible pavement. However, a robust method to evaluate pavement sections utilizing FWD data from all the sensors is seldom developed. There is always a need for DOTs and highway agencies to have a simplified procedure, which can be directly implemented in agencies' databases. This study focuses on expanding and validating the concept of previously developed area ratio parameters towards the pavement section of South-Central States (Arkansas, Louisiana, New Mexico, Oklahoma, and Texas) in effectively analyzing the pavement …

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Nonsingular Quantum Gravitational Dynamics Of An Lemaitre-Tolman-Bondi Dust Shell Model: The Role Of Quantization Prescriptions, Kristina Giesel, Bao-Fei Li, Parampreet Singh Nov 2021

Nonsingular Quantum Gravitational Dynamics Of An Lemaitre-Tolman-Bondi Dust Shell Model: The Role Of Quantization Prescriptions, Kristina Giesel, Bao-Fei Li, Parampreet Singh

Faculty Publications

We study some consequences of the loop quantization of the outermost dust shell in the LemaitreTolman-Bondi spacetime with a homogeneous dust density using different quantization strategies motivated by loop quantum gravity. Prior work has dealt with loop quantizing this model by employing holonomies and the triads, following the procedure in standard loop quantum cosmology. In this work we compare this quantization with the one in which holonomies and gauge-covariant fluxes are used. While both of the quantization schemes resolve the central singularity, they lead to different mass gaps at which a trapped surface forms. This trapped surface which is matched …

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Ncs Assessments Of The Motor, Sensory, And Physical Health Domains, Jane E. Clark, Russell Pate, Rose Marie Rine, Jennifer Christy, Pamela Dalton, Diane L. Damiano, Stephen Daniels, Jonathan M. Holmes, Peter T. Katzmarzyk, Susan Magasi, Ryan Mccreery, Kerry Mciver, Karl M. Newell, Terence Sanger, David Sugden, Elsie Taveras, Steven Hirschfeld Nov 2021

Ncs Assessments Of The Motor, Sensory, And Physical Health Domains, Jane E. Clark, Russell Pate, Rose Marie Rine, Jennifer Christy, Pamela Dalton, Diane L. Damiano, Stephen Daniels, Jonathan M. Holmes, Peter T. Katzmarzyk, Susan Magasi, Ryan Mccreery, Kerry Mciver, Karl M. Newell, Terence Sanger, David Sugden, Elsie Taveras, Steven Hirschfeld

Population and Public Health Science Faculty Publications

As part of the National Children's Study (NCS) comprehensive and longitudinal assessment of the health status of the whole child, scientific teams were convened to recommend assessment measures for the NCS. This manuscript documents the work of three scientific teams who focused on the motor, sensory, or the physical health aspects of this assessment. Each domain team offered a value proposition for the importance of their domain to the health outcomes of the developing infant and child. Constructs within each domain were identified and measures of these constructs proposed. Where available extant assessments were identified. Those constructs that were in …

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The Use Of Rna Interference To Investigate The Role Of Zmpr10 In Salt Stress Response And Mtl/Nld/Zmpla1 In The Improvement Of Haploid Induction In Maize, Max Carl Miller Nov 2021

The Use Of Rna Interference To Investigate The Role Of Zmpr10 In Salt Stress Response And Mtl/Nld/Zmpla1 In The Improvement Of Haploid Induction In Maize, Max Carl Miller

LSU Master's Theses

RNA interference (RNAi) is a useful tool in gene characterization and its use is expanding into more practical fields. Two RNAi techniques were used in this case. The studies conducted in the chapter two use transgenic maize lines containing an RNAi construct targeting ZmPR10 to characterize its potential role in growth and development in response to salinity stress. T1 transgenic plants from events A44S1-35-3 and A44S1-3-4, which had significantly reduced ZmPR10 expression compared to the non-transgenic controls, showed no differences compared to the controls in heights after 30 and 60 days, nor did the T2 transgenic from these …

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Memory Forensics Comparison Of Apple M1 And Intel Architecture Using Volatility Framework, Joshua Duke Nov 2021

Memory Forensics Comparison Of Apple M1 And Intel Architecture Using Volatility Framework, Joshua Duke

LSU Master's Theses

Memory forensics allows an investigator to get a full picture of what is occurring on-device at the time that a memory sample is captured and is frequently used to detect and analyze malware. Malicious attacks have evolved from living on disk to having persistence mechanisms in the volatile memory (RAM) of a device and the information that is captured in memory samples contains crucial information for full forensic analysis by cybersecurity professionals. Recently, Apple unveiled computers containing a custom designed system on a chip (SoC) called the M1 that is based on ARM architecture. Our research focused on the differences …

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