Digital Commons Network^™

A Systematic Review Of Environmentally Persistent Free Radical (Epfr) Formation, Characteristics, And Health Effects: Are There Sufficient Data For Risk Assessment?, Avinash Kumar, Divine Nde, Chuqi Guo, Rashmi Pathak, Fox Foley, Syed Ahmad, Prakash Dangal, Farhana Hasan, Myron Lard, Ankit Aryal, Martine E. Mathieu-Campbell, Jennifer Irving, Oluwafeyikemi Ogunmusi, Jennifer Richmond-Bryant, Slawomir Lomnicki, Lavrent Khachatryan, Stephania A. Cormier, Tammy R. Dugas

Faculty Publications

Environmentally persistent free radicals (EPFRs) are stable free radicals formed on particulate matter (PM) through processes such as combustion and pyrolysis. These free radicals are generated on transition metal oxide surfaces in the presence of aromatic precursors. Exposure to EPFRs occurs primarily via inhalation of PM deriving from combustion, traffic, industrial activities, and both indoor and outdoor burning. Other environmental factors that might generate EPFRs are radon, electronic and tobacco cigarettes. EPFRs exhibit unexpectedly long half-lives, ranging from several weeks to, in some cases, several years. EPFRs may be carbon-centered, oxygen-centered or mixed, identified by g-values exhibited in electron paramagnetic …

The Work Of An Hour: A Case Study Of Propaganda, Michael F. Russo

Faculty Publications

This research paper discusses the messaging of United States President George W. Bush and his administration regarding the U.S. led invasion of Iraq. Transcripts of presidential communications, national news programs, and public opinion polls from 2001-03 were analyzed to identify patterns in these communications. This review demonstrated techniques similar to those used in historical propaganda campaigns to sway public opinion. The introduction and repetition of key terminology from the government was followed by magnification by television news programs. These messages were broadcast despite lack of evidence of Iraq’s involvement with the 9/11 attacks or their possession of weapons of mass …

Impact Report, 2024-2025, Lsu Libraries

Libraries Impact Reports

No abstract provided.

Editorial: Advancements And Challenges In Quantum Technologies Using Low-Dimensional Systems, Nanrun Zhou, Omar Magana-Loaiza, Clebson Cruz

Faculty Publications

No abstract provided.

Chip-Based Quantum Signature Network Reaches 200 Km, Chenglong You, Omar S. Magaña-Loaiza

Faculty Publications

A pioneering chip-based quantum digital signature (QDS) network achieves secure document signing over 200 km of fiber, leveraging integrated photonics to miniaturize transmitters and centralize measurement systems. This breakthrough paves the way for future scalable, cost-effective, and robust quantum-secure communication networks.

The Intelligence Debate: Bilingualism Vs Monolingualism - A Systematic Review, Muhammad Ayyaz

Communication Sciences & Disorders Graduate Student Work

The primary aim of the study is to find out whether bilinguals are more intelligent than monolinguals. The study synthesized relevant literature on the relationship between intelligence and bilingualism with regard to Raven's matrices, a widely recognized tool to assess abstract reasoning. Given the increasing prevalence of bilingualism because of migration and globalization, gaining insight into its cognitive influence is crucial (Surrain & Luk, 2017). Fluid intelligence (gf), crystallized intelligence (gc), and general intelligence (g) are included in this study. Across multiple databases, including ERIC, PsycINFO, and Web of Science, the study involved a comprehensive literature review of the studies …

Exercise And Nutrition To Improve Cancer Treatment-Related Outcomes (Enicto), Kathryn H. Schmitz, Justin C. Brown, Melinda L. Irwin, Kim Robien, Jessica M. Scott, Nathan A. Berger, Bette Caan, Andrea Cercek, Tracy E. Crane, Scott R. Evans, Jennifer A. Ligibel, Jeffrey A. Meyerhardt, Tanya Agurs-Collins, Karen Basen-Engquist, Jennifer W. Bea, Sheng F. Cai, Brenda Cartmel, Vernon M. Chinchilli, Wendy Demark-Wahnefried, Christina M. Dieli-Conwright, Loretta Dipietro, Shawna E. Doerksen, Sharon L. Edelstein, Joanne Elena, William Evans, Leah M. Ferrucci, Julia Foldi, Sarah Freylersythe, Helena Furberg, Lee W. Jones, Ross Levine, Chaya S. Moskowitz, Cynthia Owusu

Faculty Publications

Chemotherapy treatment-related side effects are common and increase the risk of suboptimal outcomes. Exercise interventions during cancer treatment improve self-reported physical functioning, fatigue, anxiety, and depression, but it is unclear whether these interventions improve important clinical outcomes, such as chemotherapy relative dose intensity. The National Cancer Institute funded the Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO) Consortium to address this knowledge gap. This article describes the mechanisms hypothesized to underpin intervention effects on clinically relevant treatment outcomes, briefly outlines each project’s distinct research aims, summarizes the scope and organizational structure of ENICTO, and provides an overview of the …

What ‘Unexplored’ Means: Mapping Regions With Digitized Natural History Records To Look For ‘Biodiversity Blindspots’, Laymon Ball, Sheila Rodríguez-Machado, Diego Paredes-Burneo, Samantha Rutledge, David A. Boyd, David Vander Pluym, Spenser Babb-Biernacki, Austin S. Chipps, Rafet Öztürk, Yahya Terzi, Prosanta Chakrabarty

Faculty Publications

We examined global records of accessible natural history voucher collections (with publicly available data and reliable locality data) for terrestrial and freshwater vascular plants, fungi, freshwater fishes, birds, mammals, and herpetofauna (amphibians and reptiles) and highlight areas of the world that would be considered undersampled and sometimes called ‘unexplored’ (i.e., have relatively low, or no evidence of, past sampling efforts) under typical Western-scientific descriptions. We also question what ‘unexplored’ may mean in these contexts and explain how replacing the term in favor of more nuanced phrasing (e.g., ‘biodiversity blindspots,’ which emphasizes the lack of publicly available data about specimens) can …

Targeting Bacterial Transcription Factors For Infection Control: Opportunities And Challenges, Ahmed Al-Tohamy, Anne Grove

Faculty Publications

The rising threat of antibiotic resistance in pathogenic bacteria emphasizes the need for new therapeutic strategies. This review focuses on bacterial transcription factors (TFs), which play crucial roles in bacterial pathogenesis. We discuss the regulatory roles of these factors through examples, and we outline potential therapeutic strategies targeting bacterial TFs. Specifically, we discuss the use of small molecules to interfere with TF function and the development of transcription factor decoys, oligonucleotides that compete with promoters for TF binding. We also cover peptides that target the interaction between the bacterial TF and other factors, such as RNA polymerase, and the targeting …

Louisiana Agriculture Magazine, Winter 2025, Lsu Agcenter

Louisiana Agriculture

LSU AgCenter nutrition education programs have always aimed to support the health and well-being of Louisianans. Helping residents eat healthier, be more physically active and maintain a healthy weight are important parts of disease prevention. Building healthy, thriving communities across Louisiana can support reduced healthcare costs, improved workforce productivity and an enhanced quality of life for everyone in our state.

Lsu General Catalog 2025-2026, Louisiana State University And Agricultural And Mechanical College

LSU General Catalog

The LSU General Catalog describes all undergraduate and graduate departments and programs with degree requirements and courses offered for each one. The LSU General Catalog includes information on registration and financial aid as well as academic services offered to all students.

Maximum Spread Of Ks,T-Minor-Free Graphs, William Linz, Linyuan Lu, Zhiyu Wang

Faculty Publications

The spread of a graph G is the difference between the largest and smallest eigenvalue of the adjacency matrix of G. In this paper, we consider the family of graphs which contain no Ks,t-minor. We show that for any t ≥ s ≥ 2 and sufficiently large n, there is an integer ξt such that the extremal n-vertex Ks,t-minor-free graph attaining the maximum spread is the graph obtained by joining a graph L on (s −1) vertices to the disjoint union of (Formula Presented) copies of Kt and (Formula Presented) isolated vertices. Furthermore, we give an explicit formula for ξt …

Louisiana Survey 2025, Lsu Reilly Center For Media & Public Affairs

Reilly Center Louisiana Surveys

The 2025 Louisiana Survey is the latest in an annual series of statewide surveys from the Reilly Center for Media & Public Affairs at Louisiana State University’s Manship School of Mass Communication.

Reflecting the continuing evolution of survey research, we use two approaches in this year’s survey:

1. In partnership with the research firm YouGov, we administered an online survey to a nonprobability sample of Louisiana residents who participate in the YouGov panel, selected to represent the state’s adult population geographically and demographically.
2. We use a traditional probability-sampling approach to draw landline and cell phone numbers for a live-interview …

Advances In Tropical Climatology–A Review, Flávia D.S. Moraes, Craig Ramseyer, Paul W. Miller, Jill C. Trepanier

Faculty Publications

Understanding tropical climatology is essential to comprehending the atmospheric connections between the tropics and extratropical latitudes weather and climate events. In this review paper, we emphasize the advances in key areas of tropical climatology knowledge since the end of the 20th century and offer a summary, assessment, and discussion of previously published literature. Among the key areas analyzed here, we explore the advances in tropical oceanic and atmospheric variability, such as El Niño–Southern Oscillation and the Madden-Julian Oscillation, and how those teleconnection events have helped us to better understand variabilities in tropical monsoons, tropical cyclones, and drought events. We also …

Vertebrate Fossils Of Louisiana, Suyin Ting, Lorene E. Smith, Connor D. White, Irene Martí Gil

Special Publications of the Museum of Natural Science

No abstract provided.

An Early Web History Of Vaccine Skeptical Digital Rhetorics, Miles C. Coleman, Will Mari

Faculty Publications

Vaccine hesitancy is a public health threat stoked by vaccine skeptical rhetorics that circulate via the Web. While there is a body of work that studies the digital rhetorical tactics of vaccine skeptics, most of this work focuses on the Web rhetorics of the “Web 2.0” era, leaving the “Web 1.0” era relatively understudied and, in turn, foreclosing opportunities to look back before moving forward in the current moment. In efforts to yield glimpses into the antecedents of digital culture that have shaped contemporary vaccine skeptical discourses, in this article, we draw on systematically sourced website “snapshots” of vaccine skeptical …

Clocking In And Speaking Out: Navigating Workday Rhythms For Voice Behaviors, Katelyn M. Reeves

LSU Master's Theses

Employee voice behaviors help organizations identify problems, increase productivity, and enhance satisfaction. Most literature focuses on daily-level variations while neglecting potential within-day variations that may have a stronger impact on voice engagement. To investigate within-day variations, this thesis applies chronotype synchrony to explain resource depletion throughout the day, which will determine voice engagement. An experience sampling study with the day reconstruction method of 250 employees revealed that having a morning chronotype leads to a more promotive and prohibitive voice in the morning, with a decline throughout the day due to resource depletion increasing throughout the day. Further, individuals with evening …

Nipping Crime In The Bud: The Spatial Relationship Between Crime And Meeting People’S Needs, Alicia Cerquone

LSU Master's Theses

The recent high-profile killings of people by the police brought attention to police violence, and prompted activists to call for an end to police violence. Drawing from an understanding of strain theory (Merton, 1938; Farnworth & Leiber, 1989; Agnew, 1992; Agnew, 2001; Agnew, 2008) and Tucker and Cadora’s (2003) ideas of justice reinvestment, this research was designed with the belief that police funding can be better used to help people meet their basic needs of housing, healthcare, and education. This research is concerned with the spatial relationship between crime and the quality of social infrastructure, or the programs in place …

Analyzing Errors Across Nonword Repetition Tasks For Clinical Utility Among Children Who Speak African American English, Tatum Carver-Dews

LSU Master's Theses

Purpose

Within the context of African American English (AAE), this study aimed to examine the clinical utility of three different types of NWR tasks to differentiate children with Developmental Language Disorder (DLD) from those who are typically developing (TD), by percentage of phonemes correct (PPC) and by type of error (e.g., consonants or vowels; omissions or substitutions). Additionally, this study allowed for examination of the relationship between the children’s NWR performance and their density of dialect-specific forms.

Methods

The data came from 50 kindergarteners (25 females, 25 males) who had participated in a multi-year study of childhood DLD within the …

Structure Of A Model Lipid Membrane Oxidized By Human 15-Lipoxygenase-2, Jamil Nemri, Cosme Morales, Nathaniel C. Gilbert, Jaroslaw Majewski, Marcia E. Newcomer, Crystal M. Vander Zanden

Faculty Publications

Enzyme-mediated lipid oxidation is an important regulatory event in cell signaling, with oxidized lipids being potent signaling molecules that can illicit dramatic changes in cell behavior. For example, peroxidation of an arachidonoyl poly-unsaturated fatty acid by the human enzyme 15-lipoxygenase-2 (15-LOX-2) has been associated with formation of atherosclerotic plaques. Previous work on synthetically oxidized membranes has shown that oxidized lipid tails will change their conformation to facilitate interactions between the peroxide group and the lipid headgroups. However, this phenomenon has not been directly observed for a lipid membrane that has undergone enzyme-catalyzed oxidation. In this study, we report on the …

Screen Media, Obesity, And Nutrition, Amanda E. Staiano, Alyssa M. Button, Gary S. Goldfield, Thomas N. Robinson, Jorge Mota, Susan J. Woolford, Peter T. Katzmarzyk

Population and Public Health Science Faculty Publications

This chapter provides an update on and the synthesis of the most current evidence on screen use, nutritional intake, and obesity in youth. The strongest evidence of a mechanism linking screen media use to obesity is through repeated exposures to unhealthy food marketing and excess eating while viewing screens. Evidence of the neurocognitive effects on dietary consumption via the effects of executive function, satiety, and memory is emerging. Interventions to reduce children's screen time or to incorporate screen media into improving nutrition and obesity outcomes have had mixed results. The evidence base is also limited by imprecise measurements of screen …

Glucagon-Like Peptide-1 Receptor Agonist-Based Agents And Weight Loss Composition: Filling The Gaps, Robert L. Dubin, Steven B. Heymsfield, Eric Ravussin, Frank L. Greenway

Clinical Research Faculty Publications

Excess adiposity is at the root of type 2 diabetes (T2D). Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as first-line treatments for T2D based on significant weight loss results. The composition of weight loss using most diets consists of < 25% fat-free mass (FFM) loss, with the remainder from fat stores. Higher amounts of weight loss (achieved with metabolic bariatric surgery) result in greater reductions in FFM. Our aim was to assess the impact that GLP-1RA-based treatments have on FFM. We analysed studies that reported changes in FFM with the following agents: exenatide, liraglutide, semaglutide, and the dual incretin receptor agonist tirzepatide. We performed an analysis of various weight loss interventions to provide a reference for expected changes in FFM. We evaluated studies using dual-energy X-ray absorptiometry (DXA) for measuring FFM (a crude surrogate for skeletal muscle). In evaluating the composition of weight loss, the percentage lost as fat-free mass (%FFML) was equal to ΔFFM/total weight change. The %FFML using GLP-1RA-based agents was between 20% and 40%. In the 28 clinical trials evaluated, the proportion of FFM loss was highly variable, but the majority reported %FFML exceeding 25%. Our review was limited to small substudies and the use of DXA, which does not measure skeletal muscle mass directly. Since FFM contains a variable amount of muscle (approximately 55%), this indirect measure may explain the heterogeneity in the data. Assessing quantity and quality of skeletal muscle using advanced imaging (magnetic resonance imaging) with functional testing will help fill the gaps in our current understanding.

Precision Prognostics For Cardiovascular Disease In Type 2 Diabetes: A Systematic Review And Meta-Analysis, Abrar Ahmad, Lee Ling Lim, Mario Luca Morieri, Claudia Ha Ting Tam, Feifei Cheng, Tinashe Chikowore, Monika Dudenhöffer-Pfeifer, Hugo Fitipaldi, Chuiguo Huang, Sarah Kanbour, Sudipa Sarkar, Robert Wilhelm Koivula, Ayesha A. Motala, Sok Cin Tye, Gechang Yu, Yingchai Zhang, Michele Provenzano, Diana Sherifali, Russell J. De Souza, Russell J. De Souza, Deirdre Kay Tobias, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo

Clinical Research Faculty Publications

Background: Precision medicine has the potential to improve cardiovascular disease (CVD) risk prediction in individuals with Type 2 diabetes (T2D). Methods: We conducted a systematic review and meta-analysis of longitudinal studies to identify potentially novel prognostic factors that may improve CVD risk prediction in T2D. Out of 9380 studies identified, 416 studies met inclusion criteria. Outcomes were reported for 321 biomarker studies, 48 genetic marker studies, and 47 risk score/model studies. Results: Out of all evaluated biomarkers, only 13 showed improvement in prediction performance. Results of pooled meta-analyses, non-pooled analyses, and assessments of improvement in prediction performance and risk of …

Vegetation Dieback In The Mississippi River Delta Triggered By Acute Drought And Chronic Relative Sea-Level Rise, Tracy Elsey-Quirk, Austin Lynn, Michael Derek Jacobs, Rodrigo Diaz, James T. Cronin, Lixia Wang, Haosheng Huang, Dubravko Justic

Faculty Publications

Coastal wetlands are vulnerable to sea-level rise. Here, the authors use 16 years of data to correlate vegetation dieback in the Mississippi River Delta to drought-induced salt water intrusion in the summer of 2012.

Covid, Elite Rhetoric, And Americans’ Attitudes Toward U.S. Trade Practices With China, Dmitriy Nurullayev, Ping Xu, James Garand

Faculty Publications

Objectives: In this article, we consider how the COVID-19 pandemic and evaluations of Donald Trump combined to influence Americans' attitudes toward U.S. trade practices with China. We suggest that psychological factors—such as confirmation bias and transfer of grievances—influence how individuals evaluate the costs and benefits of trade. Specifically, we argue that the severity of the pandemic (reflected by both cumulative deaths and news coverage of the pandemic) and the rhetoric of (then) President Trump came together to influence Americans’ attitudes toward trade with China. Methods: To assess the COVID effect, the Trump effect, and their interaction effect on trade opinion, …

Correction To: Genotype-Stratified Treatment For Monogenic Insulin Resistance: A Systematic Review (Communications Medicine, (2023), 3, 1, (134), 10.1038/S43856-023-00368-9), Robert K. Semple, Kashyap A. Patel, Sungyoung Auh, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Rinki Murphy, Viswanathan Mohan, Shivani Misra, James B. Meigs, Nestoras Mathioudakis, Chantal Mathieu, Ronald C.W. Ma, Ruth J.F. Loos, Siew S. Lim, Lori M. Laffel

Clinical Research Faculty Publications

Correction to: Communications Medicinehttps://doi.org/10.1038/s43856-023-00368-9, published online 05 October 2023 The file Supplementary Data 3 was missing when this article was published. It has now been added and can be accessed via the Supplementary information section in the online version of the article. Citations to Supplementary Data 3 in the article remain unchanged.

Early Life Energy Balance: The Development Of Infant Energy Expenditure And Intake In The Context Of Obesity, Emily W. Flanagan, Leanne M. Redman

Clinical Research Faculty Publications

Purpose of Review: This review aims to provide a summary of the current knowledge on measurement tools and most recent evidence for prenatal and postnatal modulators of energy balance in young infants. Recent Findings: The prevention of pediatric obesity depends upon curating the perfect imbalance of energy intake to energy expenditure, taking into consideration the energy needs for healthy growth. We summarize the recent evidence for the programming of fetal and infant metabolism influenced by maternal preconception health, prenatal metabolic milieu, and physical activity behaviors. In the early postnatal environment, caregiver feeding behaviors shape the extent of energy imbalance through …

Precision Treatment Of Beta-Cell Monogenic Diabetes: A Systematic Review, Rochelle N. Naylor, Kashyap A. Patel, Jarno L.T. Kettunen, Jonna M.E. Männistö, Julie Støy, Julie Støy, Jacques Beltrand, Michel Polak, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Rinki Murphy, Viswanathan Mohan, Shivani Misra, James B. Meigs

Clinical Research Faculty Publications

Background: Beta-cell monogenic forms of diabetes have strong support for precision medicine. We systematically analyzed evidence for precision treatments for GCK-related hyperglycemia, HNF1A-, HNF4A- and HNF1B-diabetes, and mitochondrial diabetes (MD) due to m.3243 A > G variant, 6q24-transient neonatal diabetes mellitus (TND) and SLC19A2-diabetes. Methods: The search of PubMed, MEDLINE, and Embase for individual and group level data for glycemic outcomes using inclusion (English, original articles written after 1992) and exclusion (VUS, multiple diabetes types, absent/aggregated treatment effect measures) criteria. The risk of bias was assessed using NHLBI study-quality assessment tools. Data extracted from Covidence were summarized and presented as descriptive …

Effective Interventions In Preventing Gestational Diabetes Mellitus: A Systematic Review And Meta-Analysis, Wubet Worku Takele, Kimberly K. Vesco, Jami Josefson, Leanne M. Redman, Wesley Hannah, Wesley Hannah, Maxine P. Bonham, Mingling Chen, Sian C. Chivers, Andrea J. Fawcett, Andrea J. Fawcett, Jessica A. Grieger, Nahal Habibi, Gloria K.W. Leung, Kai Liu, Eskedar G. Mekonnen, Eskedar G. Mekonnen, Maleesa Pathirana, Alejandra Quinteros, Rachael Taylor, Gebresilasea G. Ukke, Gebresilasea G. Ukke, Shao J. Zhou, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds

Clinical Research Faculty Publications

Background: Lifestyle choices, metformin, and dietary supplements may prevent GDM, but the effect of intervention characteristics has not been identified. This review evaluated intervention characteristics to inform the implementation of GDM prevention interventions. Methods: Ovid, MEDLINE/PubMed, and EMBASE databases were searched. The Template for Intervention Description and Replication (TIDieR) framework was used to examine intervention characteristics (who, what, when, where, and how). Subgroup analysis was performed by intervention characteristics. Results: 116 studies involving 40,940 participants are included. Group-based physical activity interventions (RR 0.66; 95% CI 0.46, 0.95) reduce the incidence of GDM compared with individual or mixed (individual and group) …

Islet Autoantibodies As Precision Diagnostic Tools To Characterize Heterogeneity In Type 1 Diabetes: A Systematic Review, Jamie L. Felton, Maria J. Redondo, Richard A. Oram, Richard A. Oram, Cate Speake, S. Alice Long, Suna Onengut-Gumuscu, Stephen S. Rich, Stephen S. Rich, Gabriela S.F. Monaco, Arianna Harris-Kawano, Dianna Perez, Zeb Saeed, Benjamin Hoag, Rashmi Jain, Carmella Evans-Molina, Linda A. Dimeglio, Heba M. Ismail, Dana Dabelea, Randi K. Johnson, Marzhan Urazbayeva, John M. Wentworth, Kurt J. Griffin, Kurt J. Griffin, Emily K. Sims, Emily K. Sims, Paul W. Franks, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Jennifer L. Sherr

Clinical Research Faculty Publications

Background: Islet autoantibodies form the foundation for type 1 diabetes (T1D) diagnosis and staging, but heterogeneity exists in T1D development and presentation. We hypothesized that autoantibodies can identify heterogeneity before, at, and after T1D diagnosis, and in response to disease-modifying therapies. Methods: We systematically reviewed PubMed and EMBASE databases (6/14/2022) assessing 10 years of original research examining relationships between autoantibodies and heterogeneity before, at, after diagnosis, and in response to disease-modifying therapies in individuals at-risk or within 1 year of T1D diagnosis. A critical appraisal checklist tool for cohort studies was modified and used for risk of bias assessment. Results: …