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The Yang-Mills Heat Equation On Three-Manifolds With Boundary, Nelia Charalambous Dec 2020

The Yang-Mills Heat Equation On Three-Manifolds With Boundary, Nelia Charalambous

Journal of Stochastic Analysis

No abstract provided.

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Machine Learning Based Applications For Data Visualization, Modeling, Control, And Optimization For Chemical And Biological Systems, Yan Ma Dec 2020

Machine Learning Based Applications For Data Visualization, Modeling, Control, And Optimization For Chemical And Biological Systems, Yan Ma

LSU Doctoral Dissertations

This dissertation report covers Yan Ma’s Ph.D. research with applicational studies of machine learning in manufacturing and biological systems. The research work mainly focuses on reaction modeling, optimization, and control using a deep learning-based approaches, and the work mainly concentrates on deep reinforcement learning (DRL). Yan Ma’s research also involves with data mining with bioinformatics. Large-scale data obtained in RNA-seq is analyzed using non-linear dimensionality reduction with Principal Component Analysis (PCA), t-Distributed Stochastic Neighbor Embedding (t-SNE), and Uniform Manifold Approximation and Projection (UMAP), followed by clustering analysis using k-Means and Hierarchical Density-Based Spatial Clustering with Noise (HDBSCAN). This report focuses …

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Emergence Of Quantum Theories From Classical Probability: Historical Origins, Developments, And Open Problems, Luigi Accardi, Yun-Gang Lu Dec 2020

Emergence Of Quantum Theories From Classical Probability: Historical Origins, Developments, And Open Problems, Luigi Accardi, Yun-Gang Lu

Journal of Stochastic Analysis

No abstract provided.

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An Asymptotic Formula For Integrals Of Products Of Jacobi Polynomials, Maxim Derevyagin, Nicholas Juricic Dec 2020

An Asymptotic Formula For Integrals Of Products Of Jacobi Polynomials, Maxim Derevyagin, Nicholas Juricic

Journal of Stochastic Analysis

No abstract provided.

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Challenges And Opportunities With Causal Discovery Algorithms: Application To Alzheimer’S Pathophysiology, Xinpeng Shen, Sisi Ma, Prashanthi Vemuri, Gyorgy Simon, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, Andrew J. Saykin, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, David Holtzman, M. Marcel Mesulam, William Potter, Peter Snyder, Adam Schwartz, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter Dec 2020

Challenges And Opportunities With Causal Discovery Algorithms: Application To Alzheimer’S Pathophysiology, Xinpeng Shen, Sisi Ma, Prashanthi Vemuri, Gyorgy Simon, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, Andrew J. Saykin, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, David Holtzman, M. Marcel Mesulam, William Potter, Peter Snyder, Adam Schwartz, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter

Clinical Research Faculty Publications

Causal Structure Discovery (CSD) is the problem of identifying causal relationships from large quantities of data through computational methods. With the limited ability of traditional association-based computational methods to discover causal relationships, CSD methodologies are gaining popularity. The goal of the study was to systematically examine whether (i) CSD methods can discover the known causal relationships from observational clinical data and (ii) to offer guidance to accurately discover known causal relationships. We used Alzheimer’s disease (AD), a complex progressive disease, as a model because the well-established evidence provides a “gold-standard” causal graph for evaluation. We evaluated two CSD methods, Fast …

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Women Leaders And Policy Compliance During A Public Health Crisis, Nichole M. Bauer, Jeong Hyun Kim, Yesola Kweon Dec 2020

Women Leaders And Policy Compliance During A Public Health Crisis, Nichole M. Bauer, Jeong Hyun Kim, Yesola Kweon

Faculty Publications

How does the gender of a political leader affect policy compliance of the public during a public health crisis? State and national leaders have taken a variety of policy measures to combat the COVID-19 pandemic, with varying levels of success. While many female leaders have been credited with containing the spread of COVID-19, often through implementing strict policy measures, there is little understanding of how individuals respond to public health policy recommendations made by female and male leaders. This article investigates whether citizens are more willing to comply with strict policy recommendations about a public health issue when those recommendations …

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First Results On Protodune-Sp Liquid Argon Time Projection Chamber Performance From A Beam Test At The Cern Neutrino Platform, B. Abi, A. Abed Abud, R. Acciarri, M. A. Acero, G. Adamov, M. Adamowski, D. Adams, P. Adrien, M. Adinolfi, Z. Ahmad, J. Ahmed, T. Alion, S. Alonso Monsalve, C. Alt, J. Anderson, C. Andreopoulos, M. P. Andrews, F. Andrianala, S. Andringa, A. Ankowski, M. Antonova, S. Antusch, A. Aranda-Fernandez, A. Ariga, L. O. Arnold, M. A. Arroyave, J. Asaadi, A. Aurisano Dec 2020

First Results On Protodune-Sp Liquid Argon Time Projection Chamber Performance From A Beam Test At The Cern Neutrino Platform, B. Abi, A. Abed Abud, R. Acciarri, M. A. Acero, G. Adamov, M. Adamowski, D. Adams, P. Adrien, M. Adinolfi, Z. Ahmad, J. Ahmed, T. Alion, S. Alonso Monsalve, C. Alt, J. Anderson, C. Andreopoulos, M. P. Andrews, F. Andrianala, S. Andringa, A. Ankowski, M. Antonova, S. Antusch, A. Aranda-Fernandez, A. Ariga, L. O. Arnold, M. A. Arroyave, J. Asaadi, A. Aurisano

Faculty Publications

The ProtoDUNE-SP detector is a single-phase liquid argon time projection chamber with an active volume of 7.2× 6.1× 7.0 m3. It is installed at the CERN Neutrino Platform in a specially-constructed beam that delivers charged pions, kaons, protons, muons and electrons with momenta in the range 0.3 GeV/c to 7 GeV/c. Beam line instrumentation provides accurate momentum measurements and particle identification. The ProtoDUNE-SP detector is a prototype for the first far detector module of the Deep Underground Neutrino Experiment, and it incorporates full-size components as designed for that module. This paper describes the beam line, the time projection chamber, the …

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Evidence For Simple Volcanic Rifting Not Complex Subduction Initiation In The Laxmi Basin, Peter D. Clift, Gérôme Calvès, Tara N. Jonell Dec 2020

Evidence For Simple Volcanic Rifting Not Complex Subduction Initiation In The Laxmi Basin, Peter D. Clift, Gérôme Calvès, Tara N. Jonell

Faculty Publications

No abstract provided.

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A Magma Ocean Origin To Divergent Redox Evolutions Of Rocky Planetary Bodies And Early Atmospheres, Jie Deng, Zhixue Du, Bijaya B. Karki, Dipta B. Ghosh, Kanani K.M. Lee Dec 2020

A Magma Ocean Origin To Divergent Redox Evolutions Of Rocky Planetary Bodies And Early Atmospheres, Jie Deng, Zhixue Du, Bijaya B. Karki, Dipta B. Ghosh, Kanani K.M. Lee

Faculty Publications

Magma oceans were once ubiquitous in the early solar system, setting up the initial conditions for different evolutionary paths of planetary bodies. In particular, the redox conditions of magma oceans may have profound influence on the redox state of subsequently formed mantles and the overlying atmospheres. The relevant redox buffering reactions, however, remain poorly constrained. Using first-principles simulations combined with thermodynamic modeling, we show that magma oceans of Earth, Mars, and the Moon are likely characterized with a vertical gradient in oxygen fugacity with deeper magma oceans invoking more oxidizing surface conditions. This redox zonation may be the major cause …

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Computer-Based And Paper-And-Pencil Tests: A Study In Calculus For Stem Majors, Lawrence Smolinsky, Brian D. Marx, Gestur Olafsson, Yanxia A. Ma Dec 2020

Computer-Based And Paper-And-Pencil Tests: A Study In Calculus For Stem Majors, Lawrence Smolinsky, Brian D. Marx, Gestur Olafsson, Yanxia A. Ma

Faculty Publications

Computer-based testing is an expanding use of technology offering advantages to teachers and students. We studied Calculus II classes for science, technology, engineering, and mathematics majors using different testing modes. Three sections with 324 students employed: paper-and-pencil testing, computer-based testing, and both. Computer tests gave immediate feedback and allowed multiple submissions and pooling. Paper-and-pencil tests (PPTs) required work and explanation allowing inspection of high cognitive demand tasks. Each test mode used the strength of its method. Students were given the same lecture by the same instructor on the same day and the same homework assignments and due dates. The design …

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17Β-Estradiol Promotes Acute Refeeding In Hungry Mice Via Membrane-Initiated Erα Signaling, Kaifan Yu, Yanlin He, Ilirjana Hyseni, Zhou Pei, Yongjie Yang, Pingwen Xu, Xing Cai, Hesong Liu, Na Qu, Hailan Liu, Yang He, Meng Yu, Chen Liang, Tingting Yang, Julia Wang, Pierre Gourdy, Jean Francois Arnal, Francoise Lenfant, Yong Xu, Chunmei Wang Dec 2020

17Β-Estradiol Promotes Acute Refeeding In Hungry Mice Via Membrane-Initiated Erα Signaling, Kaifan Yu, Yanlin He, Ilirjana Hyseni, Zhou Pei, Yongjie Yang, Pingwen Xu, Xing Cai, Hesong Liu, Na Qu, Hailan Liu, Yang He, Meng Yu, Chen Liang, Tingting Yang, Julia Wang, Pierre Gourdy, Jean Francois Arnal, Francoise Lenfant, Yong Xu, Chunmei Wang

Division of Basic Science Faculty Publications

Objective: Estrogen protects animals from obesity through estrogen receptor α (ERα), partially by inhibiting overeating in animals fed ad libitum. However, the effects of estrogen on feeding behavior in hungry animals remain unclear. In this study, we examined the roles of 17β-estradiol (E2) and ERα in the regulation of feeding in hungry female animals and explored the underlying mechanisms. Methods: Wild-type female mice with surgical depletion of endogenous estrogens were used to examine the effects of E2 supplementation on acute refeeding behavior after starvation. ERα-C451A mutant mice deficient in membrane-bound ERα activity and ERα-AF20 mutant mice lacking ERα transcriptional activity …

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Estrogen Receptor-Α Expressing Neurons In The Ventrolateral Vmh Regulate Glucose Balance, Yanlin He, Pingwen Xu, Chunmei Wang, Yan Xia, Meng Yu, Yongjie Yang, Kaifan Yu, Xing Cai, Na Qu, Kenji Saito, Julia Wang, Ilirjana Hyseni, Matthew Robertson, Badrajee Piyarathna, Min Gao, Sohaib A. Khan, Feng Liu, Rui Chen, Cristian Coarfa, Zhongming Zhao, Qingchun Tong, Zheng Sun, Yong Xu Dec 2020

Estrogen Receptor-Α Expressing Neurons In The Ventrolateral Vmh Regulate Glucose Balance, Yanlin He, Pingwen Xu, Chunmei Wang, Yan Xia, Meng Yu, Yongjie Yang, Kaifan Yu, Xing Cai, Na Qu, Kenji Saito, Julia Wang, Ilirjana Hyseni, Matthew Robertson, Badrajee Piyarathna, Min Gao, Sohaib A. Khan, Feng Liu, Rui Chen, Cristian Coarfa, Zhongming Zhao, Qingchun Tong, Zheng Sun, Yong Xu

Division of Basic Science Faculty Publications

Brain glucose-sensing neurons detect glucose fluctuations and prevent severe hypoglycemia, but mechanisms mediating functions of these glucose-sensing neurons are unclear. Here we report that estrogen receptor-α (ERα)-expressing neurons in the ventrolateral subdivision of the ventromedial hypothalamic nucleus (vlVMH) can sense glucose fluctuations, being glucose-inhibited neurons (GI-ERαvlVMH) or glucose-excited neurons (GE-ERαvlVMH). Hypoglycemia activates GI-ERαvlVMH neurons via the anoctamin 4 channel, and inhibits GE-ERαvlVMH neurons through opening the ATP-sensitive potassium channel. Further, we show that GI-ERαvlVMH neurons preferentially project to the medioposterior arcuate nucleus of the hypothalamus (mpARH) and GE-ERαvlVMH neurons preferentially project to the dorsal Raphe nuclei (DRN). Activation of ERαvlVMH …

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Estrogen-Sensitive Medial Preoptic Area Neurons Coordinate Torpor In Mice, Zhi Zhang, Fernando M.C.V. Reis, Yanlin He, Jae W. Park, Johnathon R. Divittorio, Nilla Sivakumar, J. Edward Van Veen, Sandra Maesta-Pereira, Michael Shum, India Nichols, Megan G. Massa, Shawn Anderson, Ketema Paul, Marc Liesa, Olujimi A. Ajijola, Yong Xu, Avishek Adhikari, Stephanie M. Correa Dec 2020

Estrogen-Sensitive Medial Preoptic Area Neurons Coordinate Torpor In Mice, Zhi Zhang, Fernando M.C.V. Reis, Yanlin He, Jae W. Park, Johnathon R. Divittorio, Nilla Sivakumar, J. Edward Van Veen, Sandra Maesta-Pereira, Michael Shum, India Nichols, Megan G. Massa, Shawn Anderson, Ketema Paul, Marc Liesa, Olujimi A. Ajijola, Yong Xu, Avishek Adhikari, Stephanie M. Correa

Division of Basic Science Faculty Publications

Homeotherms maintain a stable internal body temperature despite changing environments. During energy deficiency, some species can cease to defend their body temperature and enter a hypothermic and hypometabolic state known as torpor. Recent advances have revealed the medial preoptic area (MPA) as a key site for the regulation of torpor in mice. The MPA is estrogen-sensitive and estrogens also have potent effects on both temperature and metabolism. Here, we demonstrate that estrogen-sensitive neurons in the MPA can coordinate hypothermia and hypometabolism in mice. Selectively activating estrogen-sensitive MPA neurons was sufficient to drive a coordinated depression of metabolic rate and body …

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Review Of The Validity And Feasibility Of Image-Assisted Methods For Dietary Assessment, Christoph Höchsmann, Corby K. Martin Dec 2020

Review Of The Validity And Feasibility Of Image-Assisted Methods For Dietary Assessment, Christoph Höchsmann, Corby K. Martin

Clinical Research Faculty Publications

Accurately quantifying dietary intake is essential to understanding the effect of diet on health and evaluating the efficacy of dietary interventions. Self-report methods (e.g., food records) are frequently utilized despite evident inaccuracy of these methods at assessing energy and nutrient intake. Methods that assess food intake via images of foods have overcome many of the limitations of traditional self-report. In cafeteria settings, digital photography has proven to be unobtrusive and accurate and is the method of choice for assessing food provision, plate waste, and food intake. In free-living conditions, image capture of food selection and plate waste via the user’s …

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Families Coping With Financial Loss Following The Deepwater Horizon Oil Spill, Kathryn Sweet Keating, Sarah Becker, Ifeyinwa F. Davis, Thomas Chandler, Tim Slack, Jaishree Beedasy Dec 2020

Families Coping With Financial Loss Following The Deepwater Horizon Oil Spill, Kathryn Sweet Keating, Sarah Becker, Ifeyinwa F. Davis, Thomas Chandler, Tim Slack, Jaishree Beedasy

Faculty Publications

Objective: This study examines family strategies for coping and adaptation to social disruption from the 2010 Deepwater Horizon oil spill (DHOS) in south Louisiana. Background: The DHOS is a technological disaster of unprecedented scale and ongoing impact, including the socioeconomic disruption of families. Method: Using data from focus groups, grounded-theory methods informed a thematic analysis of spill-related economic loss and coping mechanisms among families in the spill-affected region. Results: Key findings were as follows: (a) long-term economic impacts persisted but were nuanced and differed across places; (b) for families living in multistressor environments, concerns about the DHOS spilled over into …

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2020 Who Guidelines On Physical Activity And Sedentary Behaviour For Children And Adolescents Aged 5–17 Years: Summary Of The Evidence, Jean Philippe Chaput, Juana Willumsen, Fiona Bull, Roger Chou, Ulf Ekelund, Joseph Firth, Russell Jago, Francisco B. Ortega, Peter T. Katzmarzyk Dec 2020

2020 Who Guidelines On Physical Activity And Sedentary Behaviour For Children And Adolescents Aged 5–17 Years: Summary Of The Evidence, Jean Philippe Chaput, Juana Willumsen, Fiona Bull, Roger Chou, Ulf Ekelund, Joseph Firth, Russell Jago, Francisco B. Ortega, Peter T. Katzmarzyk

Population and Public Health Science Faculty Publications

Background: The World Health Organization (WHO) released in 2020 updated global guidelines on physical activity and sedentary behaviour for children, adolescents, adults, older adults and sub-populations such as pregnant and postpartum women and those living with chronic conditions or disabilities. Objective: To summarize the evidence on the associations between physical activity, sedentary behaviour, and health-related outcomes used to inform the 2020 WHO guidelines on physical activity and sedentary behaviour for children and adolescents aged 5–17 years. Methods: The update of the WHO guideline recommendations for children and adolescents utilized and systematically updated the evidence syntheses on physical activity and sedentary …

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New Global Guidelines On Sedentary Behaviour And Health For Adults: Broadening The Behavioural Targets, Paddy C. Dempsey, Stuart J.H. Biddle, Matthew P. Buman, Sebastien Chastin, Ulf Ekelund, Christine M. Friedenreich, Peter T. Katzmarzyk, Michael F. Leitzmann, Emmanuel Stamatakis, Hidde P. Van Der Ploeg, Juana Willumsen, Fiona Bull Dec 2020

New Global Guidelines On Sedentary Behaviour And Health For Adults: Broadening The Behavioural Targets, Paddy C. Dempsey, Stuart J.H. Biddle, Matthew P. Buman, Sebastien Chastin, Ulf Ekelund, Christine M. Friedenreich, Peter T. Katzmarzyk, Michael F. Leitzmann, Emmanuel Stamatakis, Hidde P. Van Der Ploeg, Juana Willumsen, Fiona Bull

Population and Public Health Science Faculty Publications

Background: In 2018, the World Health Organisation (WHO) commenced a program of work to update the 2010 Global Recommendations on Physical Activity for Health, for the first-time providing population-based guidelines on sedentary behaviour. This paper briefly summarizes and highlights the scientific evidence behind the new sedentary behaviour guidelines for all adults and discusses its strengths and limitations, including evidence gaps/research needs and potential implications for public health practice. Methods: An overview of the scope and methods used to update the evidence is provided, along with quality assessment and grading methods for the eligible new systematic reviews. The literature search update …

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World Health Organization 2020 Guidelines On Physical Activity And Sedentary Behaviour, Fiona C. Bull, Salih S. Al-Ansari, Stuart Biddle, Katja Borodulin, Matthew P. Buman, Greet Cardon, Catherine Carty, Jean Philippe Chaput, Sebastien Chastin, Roger Chou, Paddy C. Dempsey, Loretta Dipietro, Ulf Ekelund, Joseph Firth, Christine M. Friedenreich, Leandro Garcia, Muthoni Gichu, Russell Jago, Peter T. Katzmarzyk, Estelle Lambert, Michael Leitzmann, Karen Milton, Francisco B. Ortega, Chathuranga Ranasinghe, Emmanuel Stamatakis, Anne Tiedemann, Richard P. Troiano, Hidde P. Van Der Ploeg, Vicky Wari, Juana F. Willumsen Dec 2020

World Health Organization 2020 Guidelines On Physical Activity And Sedentary Behaviour, Fiona C. Bull, Salih S. Al-Ansari, Stuart Biddle, Katja Borodulin, Matthew P. Buman, Greet Cardon, Catherine Carty, Jean Philippe Chaput, Sebastien Chastin, Roger Chou, Paddy C. Dempsey, Loretta Dipietro, Ulf Ekelund, Joseph Firth, Christine M. Friedenreich, Leandro Garcia, Muthoni Gichu, Russell Jago, Peter T. Katzmarzyk, Estelle Lambert, Michael Leitzmann, Karen Milton, Francisco B. Ortega, Chathuranga Ranasinghe, Emmanuel Stamatakis, Anne Tiedemann, Richard P. Troiano, Hidde P. Van Der Ploeg, Vicky Wari, Juana F. Willumsen

Population and Public Health Science Faculty Publications

Objectives To describe new WHO 2020 guidelines on physical activity and sedentary behaviour. Methods The guidelines were developed in accordance with WHO protocols. An expert Guideline Development Group reviewed evidence to assess associations between physical activity and sedentary behaviour for an agreed set of health outcomes and population groups. The assessment used and systematically updated recent relevant systematic reviews; new primary reviews addressed additional health outcomes or subpopulations. Results The new guidelines address children, adolescents, adults, older adults and include new specific recommendations for pregnant and postpartum women and people living with chronic conditions or disability. All adults should undertake …

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Advancing The Global Physical Activity Agenda: Recommendations For Future Research By The 2020 Who Physical Activity And Sedentary Behavior Guidelines Development Group, Loretta Dipietro, Salih Saad Al-Ansari, Stuart J.H. Biddle, Katja Borodulin, Fiona C. Bull, Matthew P. Buman, Greet Cardon, Catherine Carty, Jean Philippe Chaput, Sebastien Chastin, Roger Chou, Paddy C. Dempsey, Ulf Ekelund, Joseph Firth, Christine M. Friedenreich, Leandro Garcia, Muthoni Gichu, Russell Jago, Peter T. Katzmarzyk, Estelle Lambert, Michael Leitzmann, Karen Milton, Francisco B. Ortega, Chathuranga Ranasinghe, Emmanuel Stamatakis, Anne Tiedemann, Richard P. Troiano, Hidde P. Van Der Ploeg, Juana F. Willumsen Dec 2020

Advancing The Global Physical Activity Agenda: Recommendations For Future Research By The 2020 Who Physical Activity And Sedentary Behavior Guidelines Development Group, Loretta Dipietro, Salih Saad Al-Ansari, Stuart J.H. Biddle, Katja Borodulin, Fiona C. Bull, Matthew P. Buman, Greet Cardon, Catherine Carty, Jean Philippe Chaput, Sebastien Chastin, Roger Chou, Paddy C. Dempsey, Ulf Ekelund, Joseph Firth, Christine M. Friedenreich, Leandro Garcia, Muthoni Gichu, Russell Jago, Peter T. Katzmarzyk, Estelle Lambert, Michael Leitzmann, Karen Milton, Francisco B. Ortega, Chathuranga Ranasinghe, Emmanuel Stamatakis, Anne Tiedemann, Richard P. Troiano, Hidde P. Van Der Ploeg, Juana F. Willumsen

Population and Public Health Science Faculty Publications

Background: In July, 2019, the World Health Organization (WHO) commenced work to update the 2010 Global Recommendations on Physical Activity for Health and established a Guideline Development Group (GDG) comprising expert public health scientists and practitioners to inform the drafting of the 2020 Guidelines on Physical Activity and Sedentary Behavior. The overall task of the GDG was to review the scientific evidence and provide expert advice to the WHO on the amount of physical activity and sedentary behavior associated with optimal health in children and adolescents, adults, older adults (> 64 years), and also specifically in pregnant and postpartum women …

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Chronic Intermittent Hypoxia Triggers A Senescence-Like Phenotype In Human White Preadipocytes, Katarzyna Polonis, Christiane Becari, C. Anwar A. Chahal, Yuebo Zhang, Alina M. Allen, Todd A. Kellogg, Virend K. Somers, Prachi Singh Dec 2020

Chronic Intermittent Hypoxia Triggers A Senescence-Like Phenotype In Human White Preadipocytes, Katarzyna Polonis, Christiane Becari, C. Anwar A. Chahal, Yuebo Zhang, Alina M. Allen, Todd A. Kellogg, Virend K. Somers, Prachi Singh

Clinical Research Faculty Publications

Obstructive sleep apnea (OSA) is a common sleep disorder associated with obesity. Emerging evidence suggest that OSA increases the risk of cardiovascular morbidity and mortality partly via accelerating the process of cellular aging. Thus, we sought to examine the effects of intermittent hypoxia (IH), a hallmark of OSA, on senescence in human white preadipocytes. We demonstrate that chronic IH is associated with an increased generation of mitochondrial reactive oxygen species along with increased prevalence of cells with nuclear localization of γH2AX & p16. A higher prevalence of cells positive for senescence-associated β-galactosidase activity was also evident with chronic IH exposure. …

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Genetic Correlations And Genome-Wide Associations Of Cortical Structure In General Population Samples Of 22,824 Adults, Edith Hofer, Gennady V. Roshchupkin, Hieab H.H. Adams, Maria J. Knol, Honghuang Lin, Shuo Li, Habil Zare, Shahzad Ahmad, Nicola J. Armstrong, Claudia L. Satizabal, Manon Bernard, Joshua C. Bis, Nathan A. Gillespie, Michelle Luciano, Aniket Mishra, Markus Scholz, Alexander Teumer, Rui Xia, Xueqiu Jian, Thomas H. Mosley, Yasaman Saba, Lukas Pirpamer, Stephan Seiler, James T. Becker, Owen Carmichael, Jerome I. Rotter, Bruce M. Psaty, Oscar L. Lopez, Najaf Amin, Sven J. Van Der Lee, Qiong Yang, Jayandra J. Himali, Pauline Maillard, Alexa S. Beiser Dec 2020

Genetic Correlations And Genome-Wide Associations Of Cortical Structure In General Population Samples Of 22,824 Adults, Edith Hofer, Gennady V. Roshchupkin, Hieab H.H. Adams, Maria J. Knol, Honghuang Lin, Shuo Li, Habil Zare, Shahzad Ahmad, Nicola J. Armstrong, Claudia L. Satizabal, Manon Bernard, Joshua C. Bis, Nathan A. Gillespie, Michelle Luciano, Aniket Mishra, Markus Scholz, Alexander Teumer, Rui Xia, Xueqiu Jian, Thomas H. Mosley, Yasaman Saba, Lukas Pirpamer, Stephan Seiler, James T. Becker, Owen Carmichael, Jerome I. Rotter, Bruce M. Psaty, Oscar L. Lopez, Najaf Amin, Sven J. Van Der Lee, Qiong Yang, Jayandra J. Himali, Pauline Maillard, Alexa S. Beiser

Clinical Research Faculty Publications

Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain …

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Long-Term Change In Physiological Markers And Cognitive Performance In Type 2 Diabetes: The Look Ahead Study, Owen T. Carmichael, Rebecca H. Neiberg, Gareth R. Dutton, Kathleen M. Hayden, Edward Horton, F. Xavier Pi-Sunyer, Karen C. Johnson, Stephen R. Rapp, Adam P. Spira, Mark A. Espeland Dec 2020

Long-Term Change In Physiological Markers And Cognitive Performance In Type 2 Diabetes: The Look Ahead Study, Owen T. Carmichael, Rebecca H. Neiberg, Gareth R. Dutton, Kathleen M. Hayden, Edward Horton, F. Xavier Pi-Sunyer, Karen C. Johnson, Stephen R. Rapp, Adam P. Spira, Mark A. Espeland

Clinical Research Faculty Publications

Context: The effects of physiological improvements on cognitive function among persons with type 2 diabetes mellitus (T2DM) are not fully understood. Objective: To determine whether improvements in physiological markers (body weight, blood sugar control, and physical activity) during intensive lifestyle intervention (ILI) are associated with enhancements in cognitive function in older adults with T2DM. Design: Multisite randomized controlled trial. Setting: Academic research centers. Patients or Other Participants: Participants were aged 45-76 years, with T2DM. Intervention: The Action for Health in Diabetes (Look AHEAD) study, a randomized, controlled clinical trial of ILI. Main Outcome Measure: Two to 3 cognitive assessments were …

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Functional Brain Architecture Is Associated With The Rate Of Tau Accumulation In Alzheimer’S Disease, Nicolai Franzmeier, Julia Neitzel, Anna Rubinski, Ruben Smith, Olof Strandberg, Rik Ossenkoppele, Oskar Hansson, Michael Ewers, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff Dec 2020

Functional Brain Architecture Is Associated With The Rate Of Tau Accumulation In Alzheimer’S Disease, Nicolai Franzmeier, Julia Neitzel, Anna Rubinski, Ruben Smith, Olof Strandberg, Rik Ossenkoppele, Oskar Hansson, Michael Ewers, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff

Clinical Research Faculty Publications

In Alzheimer’s diseases (AD), tau pathology is strongly associated with cognitive decline. Preclinical evidence suggests that tau spreads across connected neurons in an activity-dependent manner. Supporting this, cross-sectional AD studies show that tau deposition patterns resemble functional brain networks. However, whether higher functional connectivity is associated with higher rates of tau accumulation is unclear. Here, we combine resting-state fMRI with longitudinal tau-PET in two independent samples including 53 (ADNI) and 41 (BioFINDER) amyloid-biomarker defined AD subjects and 28 (ADNI) vs. 16 (BioFINDER) amyloid-negative healthy controls. In both samples, AD subjects show faster tau accumulation than controls. Second, in AD, higher …

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Spread Of Pathological Tau Proteins Through Communicating Neurons In Human Alzheimer's Disease, Jacob W. Vogel, Yasser Iturria-Medina, Olof T. Strandberg, Ruben Smith, Elizabeth Levitis, Alan C. Evans, Oskar Hansson, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles Decarli Dec 2020

Spread Of Pathological Tau Proteins Through Communicating Neurons In Human Alzheimer's Disease, Jacob W. Vogel, Yasser Iturria-Medina, Olof T. Strandberg, Ruben Smith, Elizabeth Levitis, Alan C. Evans, Oskar Hansson, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles Decarli

Clinical Research Faculty Publications

Tau is a hallmark pathology of Alzheimer’s disease, and animal models have suggested that tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (Aβ). We test this hypothesis in humans using an epidemic spreading model (ESM) to simulate tau spread, and compare these simulations to observed patterns measured using tau-PET in 312 individuals along Alzheimer’s disease continuum. Up to 70% of the variance in the overall spatial pattern of tau can be explained by our model. Surprisingly, the ESM predicts the spatial patterns of tau irrespective of whether brain Aβ is present, but regions with greater Aβ …

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Fam222a Encodes A Protein Which Accumulates In Plaques In Alzheimer’S Disease, Tingxiang Yan, Jingjing Liang, Ju Gao, Luwen Wang, Hisashi Fujioka, Michael W. Weiner, Norbert Schuff, Howard J. Rosen, Bruce L. Miller, David Perry, Paul Aisen, Paul Aisen, Arthur W. Toga, Gustavo Jimenez, Michael Donohue, Devon Gessert, Kelly Harless, Jennifer Salazar, Yuliana Cabrera, Sarah Walter, Lindsey Hergesheimer, Karen Crawford, Scott Neu, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Bryan M. Spann, Ronald Petersen, Clifford R. Jack, Matthew Bernstein, Bret Borowski, Jeff Gunter, Matt Senjem Dec 2020

Fam222a Encodes A Protein Which Accumulates In Plaques In Alzheimer’S Disease, Tingxiang Yan, Jingjing Liang, Ju Gao, Luwen Wang, Hisashi Fujioka, Michael W. Weiner, Norbert Schuff, Howard J. Rosen, Bruce L. Miller, David Perry, Paul Aisen, Paul Aisen, Arthur W. Toga, Gustavo Jimenez, Michael Donohue, Devon Gessert, Kelly Harless, Jennifer Salazar, Yuliana Cabrera, Sarah Walter, Lindsey Hergesheimer, Karen Crawford, Scott Neu, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Bryan M. Spann, Ronald Petersen, Clifford R. Jack, Matthew Bernstein, Bret Borowski, Jeff Gunter, Matt Senjem

Clinical Research Faculty Publications

Alzheimer’s disease (AD) is characterized by amyloid plaques and progressive cerebral atrophy. Here, we report FAM222A as a putative brain atrophy susceptibility gene. Our cross-phenotype association analysis of imaging genetics indicates a potential link between FAM222A and AD-related regional brain atrophy. The protein encoded by FAM222A is predominantly expressed in the CNS and is increased in brains of patients with AD and in an AD mouse model. It accumulates within amyloid deposits, physically interacts with amyloid-β (Aβ) via its N-terminal Aβ binding domain, and facilitates Aβ aggregation. Intracerebroventricular infusion or forced expression of this protein exacerbates neuroinflammation and cognitive dysfunction …

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Influence Of Energy Removal Rate On The Quality Of Minced Meat From Undersized Crawfish During Frozen Storage, Franklin Bonilla, Vondel Reyes, Alexander Chouljenko, Bennett Dzandu, Subramaniam Sathivel Dec 2020

Influence Of Energy Removal Rate On The Quality Of Minced Meat From Undersized Crawfish During Frozen Storage, Franklin Bonilla, Vondel Reyes, Alexander Chouljenko, Bennett Dzandu, Subramaniam Sathivel

Faculty Publications

Abstract: Undersized crawfish have little economic value and are often discarded. Producing crawfish minced meat (CMM) from undersized crawfish and using an appropriate freezing technique may enable an economically viable market. The objective of this research was to evaluate the effect of the energy removal rate using two techniques, cryogenic freezing (CF) and air blast freezing (BF), on CMM’s quality during frozen storage. CMM was separated into two batches; one batch was cryogenically frozen with liquid nitrogen and the other batch was frozen with an air blast freezer. CMM batches were frozen and stored at − 18 °C. They were …

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Evaluating The Implementation Of The Switch® School Wellness Intervention And Capacity-Building Process Through Multiple Methods, Gabriella M. Mcloughlin, Priscila Candal, Spyridoula Vazou, Joey A. Lee, David A. Dzewaltowski, Richard R. Rosenkranz, Lorraine Lanningham-Foster, Douglas A. Gentile, Laura Liechty, Senlin Chen, Gregory J. Welk Dec 2020

Evaluating The Implementation Of The Switch® School Wellness Intervention And Capacity-Building Process Through Multiple Methods, Gabriella M. Mcloughlin, Priscila Candal, Spyridoula Vazou, Joey A. Lee, David A. Dzewaltowski, Richard R. Rosenkranz, Lorraine Lanningham-Foster, Douglas A. Gentile, Laura Liechty, Senlin Chen, Gregory J. Welk

Faculty Publications

Background: School wellness programming is important for promoting healthy lifestyles and academic achievement in youth; however, research is needed on methods that can help schools implement and sustain such programs on their own. The purpose of this study was to investigate factors within and outside the school environment that influenced school capacity for implementation and potential sustainability of wellness programming. Methods: As part of the School Wellness Integration Targeting Child Health (SWITCH®) intervention, elementary school wellness teams (N = 30) were guided through a capacity-building process focused on promoting the adoption of healthy lifestyle behaviors in students. Data on implementation …

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Evidence Of Metasomatism In The Interior Of Vesta, Ai Cheng Zhang, Noriyuki Kawasaki, Huiming Bao, Jia Liu, Liping Qin, Minami Kuroda, Jian Feng Gao, Li Hui Chen, Ye He, Naoya Sakamoto, Hisayoshi Yurimoto Dec 2020

Evidence Of Metasomatism In The Interior Of Vesta, Ai Cheng Zhang, Noriyuki Kawasaki, Huiming Bao, Jia Liu, Liping Qin, Minami Kuroda, Jian Feng Gao, Li Hui Chen, Ye He, Naoya Sakamoto, Hisayoshi Yurimoto

Faculty Publications

© 2020, The Author(s). Diogenites are a group of meteorites that are derived from the interior of the largest protoplanet Vesta. They provide a unique opportunity to understanding together the internal structure and dynamic evolution of this protoplanet. Northwest Africa (NWA) 8321 was suggested to be an unbrecciated noritic diogenite meteorite, which is confirmed by our oxygen and chromium isotopic data. Here, we find that olivine in this sample has been partly replaced by orthopyroxene, troilite, and minor metal. The replacement texture of olivine is unambiguous evidence of sulfur-involved metasomatism in the interior of Vesta. The presence of such replacement …

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Evidence Of Metasomatism In The Interior Of Vesta, Ai Cheng Zhang, Noriyuki Kawasaki, Huiming Bao, Jia Liu, Liping Qin, Minami Kuroda, Jian Feng Gao, Li Hui Chen, Ye He, Naoya Sakamoto, Hisayoshi Yurimoto Dec 2020

Evidence Of Metasomatism In The Interior Of Vesta, Ai Cheng Zhang, Noriyuki Kawasaki, Huiming Bao, Jia Liu, Liping Qin, Minami Kuroda, Jian Feng Gao, Li Hui Chen, Ye He, Naoya Sakamoto, Hisayoshi Yurimoto

Faculty Publications

© 2020, The Author(s). Diogenites are a group of meteorites that are derived from the interior of the largest protoplanet Vesta. They provide a unique opportunity to understanding together the internal structure and dynamic evolution of this protoplanet. Northwest Africa (NWA) 8321 was suggested to be an unbrecciated noritic diogenite meteorite, which is confirmed by our oxygen and chromium isotopic data. Here, we find that olivine in this sample has been partly replaced by orthopyroxene, troilite, and minor metal. The replacement texture of olivine is unambiguous evidence of sulfur-involved metasomatism in the interior of Vesta. The presence of such replacement …

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Development Of A Self-Powered Weigh-In-Motion System, Athanassios Papagiannakis, Sarah Ahmed, Samer Dessouky, Reza Khalili, Gopal Vishwakarma Dec 2020

Development Of A Self-Powered Weigh-In-Motion System, Athanassios Papagiannakis, Sarah Ahmed, Samer Dessouky, Reza Khalili, Gopal Vishwakarma

Publications

This report describes the development of a novel weigh-in-motion (WIM) system that utilizes piezoelectric elements for sensing load and powering an ultra-low power microcontroller unit (MCU) that serves as its data acquisition system. A system of 4 piezoelectric (PZT) stacks serves as the energy harvester, while load sensing is done via a set of 4 PZT elements connected in parallel. Two alternative MCUs were considered, with various data handling capabilities and power consumption requirements. These MCUs have very short “wake-up” times allowing vehicle sensing without the need for inductive loops commonly used in conventional WIM systems. Special electric circuits were …

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