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Betacoronaviruses Sars-Cov-2 And Hcov-Oc43 Infections In Igrov-1 Cell Line Require Aryl Hydrocarbon Receptor, Meisam Yousefi, Wai Suet Lee, Wharton O.Y. Chan, Wei He, Marcus G. Mah, Cythia Lingli Yong, Joshua M. Deerain, Lijin Wang, Camille Arcinas, Biaoguo Yan, Dewei Tan, Wan Rong Sia, Akshamal M. Gamage, Jinxuan Yang, Alan Chen Yu Hsu, Shang Li, Martin Linster, Xinglou Yang, Sujoy Ghosh, Danielle E. Anderson, Gavin J.D. Smith, Chee Wah Tan, Lin Fa Wang, Yaw Shin Ooi Jan 2023

Betacoronaviruses Sars-Cov-2 And Hcov-Oc43 Infections In Igrov-1 Cell Line Require Aryl Hydrocarbon Receptor, Meisam Yousefi, Wai Suet Lee, Wharton O.Y. Chan, Wei He, Marcus G. Mah, Cythia Lingli Yong, Joshua M. Deerain, Lijin Wang, Camille Arcinas, Biaoguo Yan, Dewei Tan, Wan Rong Sia, Akshamal M. Gamage, Jinxuan Yang, Alan Chen Yu Hsu, Shang Li, Martin Linster, Xinglou Yang, Sujoy Ghosh, Danielle E. Anderson, Gavin J.D. Smith, Chee Wah Tan, Lin Fa Wang, Yaw Shin Ooi

Division of Basic Science Faculty Publications

The emergence of novel betacoronaviruses has posed significant financial and human health burdens, necessitating the development of appropriate tools to combat future outbreaks. In this study, we have characterized a human cell line, IGROV-1, as a robust tool to detect, propagate, and titrate betacoronaviruses SARS-CoV-2 and HCoV-OC43. IGROV-1 cells can be used for serological assays, antiviral drug testing, and isolating SARS-CoV-2 variants from patient samples. Using time-course transcriptomics, we confirmed that IGROV-1 cells exhibit a robust innate immune response upon SARS-CoV-2 infection, recapitulating the response previously observed in primary human nasal epithelial cells. We performed genome-wide CRISPR knockout genetic screens …

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A Review Of The Fundamental Concepts Of Cfd For Novice Users In Building Research And Design, Soo Jeong Jo, James R. Jones Jan 2023

A Review Of The Fundamental Concepts Of Cfd For Novice Users In Building Research And Design, Soo Jeong Jo, James R. Jones

Faculty Publications

Computational Fluid Dynamics (CFD) has been known as the most effective method for airflow analyses, but its complexity has been a barrier to dissemination in the building industry. Although, there have been continuous efforts to simplify the simulation process and develop more user-friendly CFD tools for novice users with reduced complexity, utilizing the tools without understanding the fundamental knowledge may bring about misleading results. The purpose of the present study is to help novice users understand the configuration process of building simulations using CFD by reviewing the fundamental concepts and proposing a framework for a simulation process in interaction with …

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Editorial: Stress-Induced Weight Changes, Hassan M. Heshmati, Livio Luzi, Frank L. Greenway, Candida J. Rebello Jan 2023

Editorial: Stress-Induced Weight Changes, Hassan M. Heshmati, Livio Luzi, Frank L. Greenway, Candida J. Rebello

Clinical Research Faculty Publications

No abstract provided.

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Obesity: A Disease Of Overnutrition, George A. Bray, Catherine M. Champagne Jan 2023

Obesity: A Disease Of Overnutrition, George A. Bray, Catherine M. Champagne

Population and Public Health Science Faculty Publications

Obesity is a serious worldwide problem that is increasing in prevalence. Obesity results from increased energy intake from food exceeding what is needed for daily energy expenditure over a considerable period of time. Obesity predicts the risk for many diseases, including diabetes, liver and gall bladder disease, infectious diseases such as SARSCov-19, and heart disease, among others. Treatments for obesity include diet, exercise, behavioral therapy, medications, and surgery.

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The Vegetarian/Flexitarian Diet, Derek C. Miketinas, Catherine M. Champagne Jan 2023

The Vegetarian/Flexitarian Diet, Derek C. Miketinas, Catherine M. Champagne

Population and Public Health Science Faculty Publications

Vegetarian diets are gaining popularity in the United States, although only a small fraction of the adult population follows some version of a vegetarian diet. Plant-based diets are heterogeneous in practice. Well-planned vegetarian and flexitarian diets can be healthy and reduce the risk of many chronic diseases. Unstructured vegetarian diets can be deficient in some nutrients like protein, omega-3 fatty acids, calcium, iron, zinc, vitamin B12, and vitamin D.

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Rbp4-Gal4, A Germline Driver That Activates In Meiosis, Reveals Functions For Vcp In Spermatid Development, Tyler J. Butsch, Alyssa E. Johnson, K. Adam Bohnert Jan 2023

Rbp4-Gal4, A Germline Driver That Activates In Meiosis, Reveals Functions For Vcp In Spermatid Development, Tyler J. Butsch, Alyssa E. Johnson, K. Adam Bohnert

Faculty Publications

Valosin-containing protein (VCP) is a versatile and ubiquitously expressed AAA+ ATPase that regulates multiple stages of Drosophila spermatogenesis. While VCP has documented roles in mitotic spermatogonia and meiotic spermatocytes, it is also highly expressed in post-meiotic spermatids, suggesting potential late-stage developmental functions as well. However, tools to assess late-stage activities of pleiotropic spermatogenesis genes such as VCP are lacking. Available germline-specific Gal4 drivers activate in stem cells or spermatogonia; consequently, knocking down VCP using one of these drivers disrupts or blocks early germ-cell development, precluding analysis of VCP in later stages. A Gal4 driver that activates later in development, such …

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Identification Of Oral Therapeutics Using An Ai Platform Against The Virus Responsible For Covid-19, Sars-Cov-2, Adam Bess, Frej Berglind, Supratik Mukhopadhyay, Michal Brylinski, Chris Alvin, Fanan Fattah, Kishor M. Wasan Jan 2023

Identification Of Oral Therapeutics Using An Ai Platform Against The Virus Responsible For Covid-19, Sars-Cov-2, Adam Bess, Frej Berglind, Supratik Mukhopadhyay, Michal Brylinski, Chris Alvin, Fanan Fattah, Kishor M. Wasan

Faculty Publications

Purpose: This study introduces a sophisticated computational pipeline, eVir, designed for the discovery of antiviral drugs based on their interactions within the human protein network. There is a pressing need for cost-effective therapeutics for infectious diseases (e.g., COVID-19), particularly in resource-limited countries. Therefore, our team devised an Artificial Intelligence (AI) system to explore repurposing opportunities for currently used oral therapies. The eVir system operates by identifying pharmaceutical compounds that mirror the effects of antiviral peptides (AVPs)—fragments of human proteins known to interfere with fundamental phases of the viral life cycle: entry, fusion, and replication. eVir extrapolates the probable antiviral efficacy …

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Gene-Educational Attainment Interactions In A Multi-Population Genome-Wide Meta-Analysis Identify Novel Lipid Loci, Lisa De Las Fuentes, Karen L. Schwander, Michael R. Brown, Amy R. Bentley, Thomas W. Winkler, Yun Ju Sung, Patricia B. Munroe, Clint L. Miller, Hugo Aschard, Stella Aslibekyan, Traci M. Bartz, Lawrence F. Bielak, Jin Fang Chai, Ching Yu Cheng, Rajkumar Dorajoo, Mary F. Feitosa, Xiuqing Guo, Fernando P. Hartwig, Andrea Horimoto, Ivana Kolčić, Elise Lim, Yongmei Liu, Alisa K. Manning, Jonathan Marten, Solomon K. Musani, Raymond Noordam, Sandosh Padmanabhan, Tuomo Rankinen, Melissa A. Richard, Paul M. Ridker, Albert V. Smith, Dina Vojinovic, Alan B. Zonderman Jan 2023

Gene-Educational Attainment Interactions In A Multi-Population Genome-Wide Meta-Analysis Identify Novel Lipid Loci, Lisa De Las Fuentes, Karen L. Schwander, Michael R. Brown, Amy R. Bentley, Thomas W. Winkler, Yun Ju Sung, Patricia B. Munroe, Clint L. Miller, Hugo Aschard, Stella Aslibekyan, Traci M. Bartz, Lawrence F. Bielak, Jin Fang Chai, Ching Yu Cheng, Rajkumar Dorajoo, Mary F. Feitosa, Xiuqing Guo, Fernando P. Hartwig, Andrea Horimoto, Ivana Kolčić, Elise Lim, Yongmei Liu, Alisa K. Manning, Jonathan Marten, Solomon K. Musani, Raymond Noordam, Sandosh Padmanabhan, Tuomo Rankinen, Melissa A. Richard, Paul M. Ridker, Albert V. Smith, Dina Vojinovic, Alan B. Zonderman

Faculty Publications

Introduction: Educational attainment, widely used in epidemiologic studies as a surrogate for socioeconomic status, is a predictor of cardiovascular health outcomes. Methods: A two-stage genome-wide meta-analysis of low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglyceride (TG) levels was performed while accounting for gene-educational attainment interactions in up to 226,315 individuals from five population groups. We considered two educational attainment variables: “Some College” (yes/no, for any education beyond high school) and “Graduated College” (yes/no, for completing a 4-year college degree). Genome-wide significant (p < 5 × 10−8) and suggestive (p < 1 × 10−6) variants were identified in Stage 1 (in up to 108,784 individuals) through genome-wide analysis, and those variants were followed up in Stage 2 studies (in up to 117,531 individuals). Results: In combined analysis of Stages 1 and 2, we identified 18 novel lipid loci (nine for LDL, seven for HDL, and two for TG) by two degree-of-freedom (2 DF) joint tests of main and interaction effects. Four loci showed significant interaction with educational attainment. Two loci were significant only in cross-population analyses. Several loci include genes with known or suggested roles in adipose (FOXP1, MBOAT4, SKP2, STIM1, STX4), brain (BRI3, FILIP1, FOXP1, LINC00290, LMTK2, MBOAT4, MYO6, SENP6, SRGAP3, STIM1, TMEM167A, TMEM30A), and liver (BRI3, FOXP1) biology, highlighting the potential importance of brain-adipose-liver communication in the regulation of lipid metabolism. An investigation of the potential druggability of genes in identified loci resulted in five gene targets shown to interact with drugs approved by the Food and Drug Administration, including genes with roles in adipose and brain tissue. Discussion: Genome-wide interaction analysis of educational attainment identified novel lipid loci not previously detected by analyses limited to main genetic effects.

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Biochemical Alterations In The Follicular Fluid Of Bovine Peri-Ovulatory Follicles And Their Association With Final Oocyte Maturation, Noof Abdulrahman Alrabiah, Constantine A. Simintiras, Alexander C.O. Evans, Patrick Lonergan, Trudee Fair Jan 2023

Biochemical Alterations In The Follicular Fluid Of Bovine Peri-Ovulatory Follicles And Their Association With Final Oocyte Maturation, Noof Abdulrahman Alrabiah, Constantine A. Simintiras, Alexander C.O. Evans, Patrick Lonergan, Trudee Fair

Faculty Publications

Follicular fluid (FF), a product of vascular transudate and granulosa and thecal cell secretions, is the milieu that has evolved to support oocyte growth and maturation which plays a central role in oocyte quality determination. Therefore, a suboptimal FF composition may be reflected in compromised oocyte progression through maturation, fertilization, or embryo development. To date, the composition of bovine FF remains understudied. To address this, we comprehensively characterized the metabolomic constituency of bovine FF in the period during which the oocyte undergoes meiotic maturation. More specifically, FF from pre (-24 h) and peri (-2 h)-ovulatory follicles was profiled by high-throughput …

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Estrus Response Patches, Timing For Artificial Insemination, And Gnrh Protocol In Split Timed Ai Beef Cattle, Danilo Demeterco, Ryon S. Walker, Luiz Ernandes Kozicki, Vitor Mohad Valle, A. K. Edwards, Jake E. Anderson, Cathleen Collet Williams Jan 2023

Estrus Response Patches, Timing For Artificial Insemination, And Gnrh Protocol In Split Timed Ai Beef Cattle, Danilo Demeterco, Ryon S. Walker, Luiz Ernandes Kozicki, Vitor Mohad Valle, A. K. Edwards, Jake E. Anderson, Cathleen Collet Williams

Faculty Publications

An estrous-detection patch was used to determine the optimum timing for STAI and the necessity of GnRH at STAI on a 7-day CO-Synch+CIDR protocol. Crossbred beef cows (n=216) were stratified into the following treatment groups: CTRL=TAI (n=67) at 72 h post CIDR removal, or TRT=STAI (n=149) at 72 or 84 h post CIDR removal. All females received GnRH (100 mcg) plus a CIDR on d0, PGF2α, CIDR removal, and an Estrotect estrous-detector patch on d7. At 72 h post-CIDR removal, a patch score was assigned (PS150% removed) to all females. Cows in the CTRL group were administered a second GnRH …

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Evidence For The Efficacy Of Pre-Harvest Agricultural Practices In Mitigating Food-Safety Risks To Fresh Produce In North America, Naresh Devarajan, Daniel L. Weller, Matthew Jones, Aiko D. Adell, Achyut Adhikari, Ana Allende, Nicole L. Arnold, Patrick Baur, Sarah M. Beno, Donna Clements, Elissa M. Olimpi, Faith Critzer, Hyatt Green, Lisa Gorski, Angela Ferelli Gruber, Jasna Kovac, Jeffery Mcgarvey, Claire M. Murphy, Sarah I. Murphy, Nora Navarro-Gonzalez, Jeb P. Owen, Alda F.A. Pires, Nicole Richard, Sandipan Samaddar, Radomir Schmidt, Kate Scow, Nikki W. Shariat, Olivia M. Smith, Austin R. Spence, Don Stoeckel, Thao D.H. Tran, Gretchen Wall, Daniel S. Karp Jan 2023

Evidence For The Efficacy Of Pre-Harvest Agricultural Practices In Mitigating Food-Safety Risks To Fresh Produce In North America, Naresh Devarajan, Daniel L. Weller, Matthew Jones, Aiko D. Adell, Achyut Adhikari, Ana Allende, Nicole L. Arnold, Patrick Baur, Sarah M. Beno, Donna Clements, Elissa M. Olimpi, Faith Critzer, Hyatt Green, Lisa Gorski, Angela Ferelli Gruber, Jasna Kovac, Jeffery Mcgarvey, Claire M. Murphy, Sarah I. Murphy, Nora Navarro-Gonzalez, Jeb P. Owen, Alda F.A. Pires, Nicole Richard, Sandipan Samaddar, Radomir Schmidt, Kate Scow, Nikki W. Shariat, Olivia M. Smith, Austin R. Spence, Don Stoeckel, Thao D.H. Tran, Gretchen Wall, Daniel S. Karp

Faculty Publications

Consumption of contaminated produce remains a leading cause of foodborne illness. Increasingly, growers are altering agricultural practices and farm environments to manage food-safety hazards, but these changes often result in substantial economic, social, and environmental costs. Here, we present a comprehensive evidence synthesis evaluating the efficacy of soil, non-crop vegetation, animal, landscape, and irrigation water management strategies aimed at reducing produce-safety risk in North America. We systematically summarized findings from 78 peer-reviewed papers on the effect of 21 management practices on the prevalence, abundance, or survival of four foodborne pathogens (i.e., E. coli, Salmonella spp., Listeria spp., and Campylobacter spp.), …

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Optimization Of Lycopene Extraction From Tomato Pomace And Effect Of Extract On Oxidative Stability Of Peanut Oil, Dinh Thi Tran, Lan Thi Hoang Nguyen, Cuong Ngoc Nguyen, Maarten L.A.T.M. Hertog, Bart Nicolaï, David Picha Jan 2023

Optimization Of Lycopene Extraction From Tomato Pomace And Effect Of Extract On Oxidative Stability Of Peanut Oil, Dinh Thi Tran, Lan Thi Hoang Nguyen, Cuong Ngoc Nguyen, Maarten L.A.T.M. Hertog, Bart Nicolaï, David Picha

Faculty Publications

Lycopene, the pigment principally responsible for the red colour of tomatoes, is well-known for its strong antioxidant property and substantial health benefits. In this study, the optimal combination of factors for lycopene extraction from tomato pomace was identified using response surface methodology. The best practically feasible results maximising both lycopene yield and antioxidant activity of the extract were obtained by applying a ratio of ethyl acetate to tomato waste of 35:1 (v/w), at a temperature of 55°C for 100 min of extraction. The extract was then added to the peanut oil to evaluate its oxidative stability during 60 days of …

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Comprehensive Meta-Analysis Of Qtl And Gene Expression Studies Identify Candidate Genes Associated With Aspergillus Flavus Resistance In Maize, Niranjan Baisakh, Eduardo A. Da Silva, Anjan K. Pradhan, Kanniah Rajasekaran Jan 2023

Comprehensive Meta-Analysis Of Qtl And Gene Expression Studies Identify Candidate Genes Associated With Aspergillus Flavus Resistance In Maize, Niranjan Baisakh, Eduardo A. Da Silva, Anjan K. Pradhan, Kanniah Rajasekaran

Faculty Publications

Aflatoxin (AF) contamination, caused by Aspergillus flavus, compromises the food safety and marketability of commodities, such as maize, cotton, peanuts, and tree nuts. Multigenic inheritance of AF resistance impedes conventional introgression of resistance traits into high-yielding commercial maize varieties. Several AF resistance-associated quantitative trait loci (QTLs) and markers have been reported from multiple biparental mapping and genome-wide association studies (GWAS) in maize. However, QTLs with large confidence intervals (CI) explaining inconsistent phenotypic variance limit their use in marker-assisted selection. Meta-analysis of published QTLs can identify significant meta-QTLs (MQTLs) with a narrower CI for reliable identification of genes and linked markers …

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Lsu General Catalog 2023-2024, Louisiana State University And Agricultural And Mechanical College Jan 2023

Lsu General Catalog 2023-2024, Louisiana State University And Agricultural And Mechanical College

LSU General Catalog

The LSU General Catalog describes all undergraduate and graduate departments and programs with degree requirements and courses offered for each one. The LSU General Catalog includes information on registration and financial aid as well as academic services offered to all students.

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The Dose-Response Effect Of Aerobic Exercise On Inflammation In Colon Cancer Survivors, Justin C. Brown, Stephanie L.E. Compton, Jeffrey A. Meyerhardt, Guillaume Spielmann, Shengping Yang Jan 2023

The Dose-Response Effect Of Aerobic Exercise On Inflammation In Colon Cancer Survivors, Justin C. Brown, Stephanie L.E. Compton, Jeffrey A. Meyerhardt, Guillaume Spielmann, Shengping Yang

Faculty Publications

Background: Physical activity after surgical resection for colon cancer is associated with significantly longer disease-free survival. Inflammation is hypothesized to mediate the association between physical activity and disease-free survival in colon cancer. Methods: In this exploratory analysis of a randomized dose-response trial, 39 colon cancer survivors who completed standard therapy were stratified by cancer stage and randomized in a 1:1:1 ratio to one of three treatment groups for 24 weeks of usual-care control, 150 min/wk of moderate-intensity aerobic exercise (low-dose), or 300 min/wk of moderate-intensity aerobic exercise (high-dose). Inflammation outcomes included high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL6), and soluble tumor …

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Editorial: Innovative Approaches To Coral Reef Science By Early Career Researchers, David A. Paz-García, Eric J. Armstrong, Iva Popovic, Raúl A. González-Pech, Michael E. Hellberg Jan 2023

Editorial: Innovative Approaches To Coral Reef Science By Early Career Researchers, David A. Paz-García, Eric J. Armstrong, Iva Popovic, Raúl A. González-Pech, Michael E. Hellberg

Faculty Publications

No abstract provided.

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Effect Of Estradiol And Predator Cues On Behavior And Brain Responses Of Captive Female House Sparrows (Passer Domesticus), Melanie G. Kimball, Courtney T. Harding, Kaitlin E. Couvillion, Keegan R. Stansberry, Tosha R. Kelly, Christine R. Lattin Jan 2023

Effect Of Estradiol And Predator Cues On Behavior And Brain Responses Of Captive Female House Sparrows (Passer Domesticus), Melanie G. Kimball, Courtney T. Harding, Kaitlin E. Couvillion, Keegan R. Stansberry, Tosha R. Kelly, Christine R. Lattin

Faculty Publications

The presence of predators can cause major changes in animal behavior, but how this interacts with hormonal state and brain activity is poorly understood. We gave female house sparrows (Passer domesticus) in post-molt condition an estradiol (n = 17) or empty implant (n = 16) for 1 week. Four weeks after implant removal, a time when female sparrows show large differences in neuronal activity to conspecific vs. heterospecific song, we exposed birds to either 30 min of conspecific song or predator calls, and video recorded their behavior. Females were then euthanized, and we examined neuronal activity using the expression of …

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The Use Of Single-Cell Sequencing To Reveal Stem/Progenitor Cells In Animal Organ Regeneration, Suxiang Lu, Igor Schneider, Honghui Zeng, Shunping He Jan 2023

The Use Of Single-Cell Sequencing To Reveal Stem/Progenitor Cells In Animal Organ Regeneration, Suxiang Lu, Igor Schneider, Honghui Zeng, Shunping He

Faculty Publications

Advances in single-cell sequencing technologies have made it possible to reveal the cellular basis of complex organ regeneration processes. In this review, we briefly introduce commonly used high-throughput single-cell sequencing platforms and their characteristics. We discuss in depth how single-cell sequencing techniques can be used in the study of regeneration to reveal stem/progenitor cell types and their developmental trajectories. From the perspective of stem cells, we review animal models of regenerative biology and organ models involved in regenerative medicine, with a focus on limb/fin/digit-tip regeneration. Finally, we discuss previous prospective work on improving systematic approaches to explore the origin and …

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Genotypic Variation Of Adaptive And Yield Component Traits Of Introduced Grain Oats (Avena Sativa L.) Grown In Bangladesh, Md Nashir Uddin, Md Ali Babar, Stephen A. Harrison, Ummea Khairun Fatema, S. M.Mostafa Kamal Khan Jan 2023

Genotypic Variation Of Adaptive And Yield Component Traits Of Introduced Grain Oats (Avena Sativa L.) Grown In Bangladesh, Md Nashir Uddin, Md Ali Babar, Stephen A. Harrison, Ummea Khairun Fatema, S. M.Mostafa Kamal Khan

Faculty Publications

Oat (Avena sativa L.) is considered a nutritious cereal. Its demand has surged across the globe steadily for half a decade, including in Bangladesh. Because there is no local variety, the current supply in Bangladesh solely relies on imports. This study aimed to introduce grain oats from the United States of America (U.S.A.) to Bangladesh and determine the extent of their adaptability and yield in this new environment. One hundred oat accessions were introduced in collaboration between North South University, Bangladesh and the University of Florida, U.S.A. They were evaluated in field conditions from November 2019 to April 2020 in …

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Germplasm The Key Factor For Development Of Oat Cultivars Urs Olada And Urs Poente, Marcelo Teixeira Pacheco, Stephen Harrison, Luiz Carlos Federizzi Jan 2023

Germplasm The Key Factor For Development Of Oat Cultivars Urs Olada And Urs Poente, Marcelo Teixeira Pacheco, Stephen Harrison, Luiz Carlos Federizzi

Faculty Publications

Cultivars URS OLADA and URS POENTE, with superior agronomic performance were bred by the Oat Breeding Program of UFRGS. These cultivars were developed using germplasm from the Quaker Oat International Nursery, a long-term collaborative program of open exchange of oats superior germplasm among breeders in a global scale.

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Leaky Gut And The Ingredients That Help Treat It: A Review, Ricardo Santos Aleman, Marvin Moncada, Kayanush J. Aryana Jan 2023

Leaky Gut And The Ingredients That Help Treat It: A Review, Ricardo Santos Aleman, Marvin Moncada, Kayanush J. Aryana

Faculty Publications

The human body is in daily contact with potentially toxic and infectious substances in the gastrointestinal tract (GIT). The GIT has the most significant load of antigens. The GIT can protect the intestinal integrity by allowing the passage of beneficial agents and blocking the path of harmful substances. Under normal conditions, a healthy intestinal barrier prevents toxic elements from entering the blood stream. However, factors such as stress, an unhealthy diet, excessive alcohol, antibiotics, and drug consumption can compromise the composition of the intestinal microbiota and the homeostasis of the intestinal barrier function of the intestine, leading to increased intestinal …

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Classification Of Plant Growth-Promoting Bacteria Inoculation Status And Prediction Of Growth-Related Traits In Tropical Maize Using Hyperspectral Image And Genomic Data, Rafael Massahiro Yassue, Giovanni Galli, Roberto Fritsche-Neto, Gota Morota Jan 2023

Classification Of Plant Growth-Promoting Bacteria Inoculation Status And Prediction Of Growth-Related Traits In Tropical Maize Using Hyperspectral Image And Genomic Data, Rafael Massahiro Yassue, Giovanni Galli, Roberto Fritsche-Neto, Gota Morota

Faculty Publications

Recent technological advances in high-throughput phenotyping have created new opportunities for the prediction of complex traits. In particular, phenomic prediction using hyperspectral reflectance could capture various signals that affect phenotypes genomic prediction might not explain. A total of 360 inbred maize (Zea mays L.) lines with or without plant growth-promoting bacterial inoculation management under nitrogen stress were evaluated using 150 spectral wavelengths ranging from 386 to 1,021 nm and 13,826 single-nucleotide polymorphisms. Six prediction models were explored to assess the predictive ability of hyperspectral and genomic data for inoculation status and plant growth-related traits. The best models for hyperspectral prediction …

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Key Parameters Linking Cyber-Physical Trust Anchors With Embedded Internet Of Things Systems, Michele Maasberg, Leslie G. Butler, Ian Taylor Jan 2023

Key Parameters Linking Cyber-Physical Trust Anchors With Embedded Internet Of Things Systems, Michele Maasberg, Leslie G. Butler, Ian Taylor

Faculty Publications

Integration of the Internet of Things (IoT) in the automotive industry has brought benefits as well as security challenges. Significant benefits include enhanced passenger safety and more comprehensive vehicle performance diagnostics. However, current onboard and remote vehicle diagnostics do not include the ability to detect counterfeit parts. A method is needed to verify authentic parts along the automotive supply chain from manufacture through installation and to coordinate part authentication with a secure database. In this study, we develop an architecture for anti-counterfeiting in automotive supply chains. The core of the architecture consists of a cyber-physical trust anchor and authentication mechanisms …

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Maternal Restricted- And Over- Feeding During Gestation Perturb Offspring Sperm Epigenome In Sheep, Linkai Zhu, Nicole Tillquist, Giovanna Scatolin, Rachael Gately, Mia Kawaida, Amanda Reiter, Sarah Reed, Steven Zinn, Kristen Govoni, Zongliang Jiang Jan 2023

Maternal Restricted- And Over- Feeding During Gestation Perturb Offspring Sperm Epigenome In Sheep, Linkai Zhu, Nicole Tillquist, Giovanna Scatolin, Rachael Gately, Mia Kawaida, Amanda Reiter, Sarah Reed, Steven Zinn, Kristen Govoni, Zongliang Jiang

Faculty Publications

In brief: Inadequate maternal nutrition during gestation can have immediate and lifelong effects on offspring. This study shows that maternal restricted - and over- nutrition during gestation do not affect semen characteristics in F1 male offspring but alters offspring sperm sncRNA profiles and DNA methylome in sheep. Abstract: There is a growing body of evidence that inadequate maternal nutrition during gestation can have immediate and lifelong effects on offspring. However, little is known about the effects of maternal nutrition during gestation on male offspring reproduction. Here, using a sheep model of maternal restricted - and over - nutrition (60 or …

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The Oncolytic Herpes Simplex Virus Type-1 (Hsv-1) Vaccine Strain Vc2 Causes Intratumor Infiltration Of Functionally Active T Cells And Inhibition Of Tumor Metastasis And Pro-Tumor Genes Vegf And Pdl1 Expression In The 4t1/Balb/C Mouse Model Of Stage Four Breast Cancer, Rafiq Nabi, Farhana Musarrat, Jose Cesar Jose, Ingeborg M. Langohr, Vladimir N. Chouljenko, Konstantin G. Kousoulas Jan 2023

The Oncolytic Herpes Simplex Virus Type-1 (Hsv-1) Vaccine Strain Vc2 Causes Intratumor Infiltration Of Functionally Active T Cells And Inhibition Of Tumor Metastasis And Pro-Tumor Genes Vegf And Pdl1 Expression In The 4t1/Balb/C Mouse Model Of Stage Four Breast Cancer, Rafiq Nabi, Farhana Musarrat, Jose Cesar Jose, Ingeborg M. Langohr, Vladimir N. Chouljenko, Konstantin G. Kousoulas

Faculty Publications

Introduction: Oncolytic viruses (OVs) provide new modalities for cancer therapy either alone or in combination with synergistic immunotherapies and/or chemotherapeutics. Engineered Herpes Simplex Virus Type-1 (HSV-1) has shown strong promise for the treatment of various cancers in experimental animal models as well as in human patients, with some virus strains licensed to treat human melanoma and gliomas. In the present study we evaluated the efficacy of mutant HSV-1 (VC2) in a late stage, highly metastatic 4T1 murine syngeneic. Method: VC2 was constructed VC2 using double red recombination technology. For in-vivo efficacy we utilized a late stage 4T1 syngeneic and immunocompetent …

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Energetic Budget Of Diploid And Triploid Eastern Oysters During A Summer Die-Off, Sarah Bodenstein, Sandra M. Casas, Terrence R. Tiersch, Jerome F. La Peyre Jan 2023

Energetic Budget Of Diploid And Triploid Eastern Oysters During A Summer Die-Off, Sarah Bodenstein, Sandra M. Casas, Terrence R. Tiersch, Jerome F. La Peyre

Faculty Publications

Triploid oysters are widely used in off-bottom aquaculture of eastern oysters, Crassostrea virginica. However, farmers of the Gulf of Mexico (GoM) and Atlantic coast estuaries have observed unresolved, late-spring die-offs of triploid oysters, threatening the sustainability of triploid aquaculture. To investigate this, the physiological processes underlying oyster growth (e.g., feeding, respiration) and mortality of one-year-old diploid and triploid oysters were compared in early summer following an uptick in mortality. It was predicted that higher triploid mortality was the result of energetic imbalances (increased metabolic demands and decreased feeding behavior). Oyster clearance rates, percentage of time valves were open, absorption efficiency, …

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Sodium Propionate Or Sodium Butyrate Promotes Fatty Acid Oxidation In Hepg2 Cells Under Oxidative Stress, Kristina J. Cook, Ann Coulter, Michael Keenan, Frank Greenway, Jack N. Losso Jan 2023

Sodium Propionate Or Sodium Butyrate Promotes Fatty Acid Oxidation In Hepg2 Cells Under Oxidative Stress, Kristina J. Cook, Ann Coulter, Michael Keenan, Frank Greenway, Jack N. Losso

Faculty Publications

The beneficial effects of sodium butyrate (NaB) and sodium propionate (NaP) on fatty acid oxidation (FAO) genes and production of proinflammatory cytokines related to nonalcoholic fatty liver disease (NAFLD) were evaluated using HepG2 human liver hepatocellular carcinoma cells exposed to palmitate/oleate or lipopolysaccharides (LPSs) as a model. The results showed that NaP or NaB was able to promote FAO, regulate lipolysis, and reduce reactive oxygen species production by significantly increasing the mRNA expression of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α), peroxisome proliferator-activated receptor alpha (PPARα), adipose triglyceride lipase (ATGL), carnitine palmitoyltransferase 1 alpha (CPT1α), fibroblast growth factor 21 …

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Novel Liquor-Based Hot Sauce: Physicochemical Attributes, Volatile Compounds, Sensory Evaluation, Consumer Perception, Emotions, And Purchase Intent, Ricardo S. Aleman, Jhunior A. Marcía, Ismael Montero-Fernández, Joan King, Shirin Kazemzadeh Pournaki, Roberta Targino Hoskin, Marvin Moncada Jan 2023

Novel Liquor-Based Hot Sauce: Physicochemical Attributes, Volatile Compounds, Sensory Evaluation, Consumer Perception, Emotions, And Purchase Intent, Ricardo S. Aleman, Jhunior A. Marcía, Ismael Montero-Fernández, Joan King, Shirin Kazemzadeh Pournaki, Roberta Targino Hoskin, Marvin Moncada

Faculty Publications

Hot sauces are popular peppery condiments used to add flavor and sensory excitement to gastronomical preparations. While hot sauce occupies a retail category well over a century old, a novel production method using liquor as the base preservative rather than traditional vinegar is now commercially available, and its uniqueness begs study. Hot sauces produced with tequila, rum, vodka, and bourbon were compared to traditional vinegar-based hot sauces concerning physicochemical properties, volatile compounds, microbiological quality, sensory scores, emotions, and purchase intent (PI). Under accelerated conditions, pH, titratable acidity (TA), water activity (Aw), viscosity, and color were analyzed weekly for 20 weeks, …

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Serum Mannan-Binding Lectin-Associated Serine Proteases In Early Pregnancy For Gestational Diabetes In Chinese Pregnant Women, Ming Gao, Jing Li, Rui Zhang, Ninghua Li, Weiqin Li, Shuang Zhang, Peng Wang, Hui Wang, Zhongze Fang, Zhijie Yu, Gang Hu, Junhong Leng, Xilin Yang Jan 2023

Serum Mannan-Binding Lectin-Associated Serine Proteases In Early Pregnancy For Gestational Diabetes In Chinese Pregnant Women, Ming Gao, Jing Li, Rui Zhang, Ninghua Li, Weiqin Li, Shuang Zhang, Peng Wang, Hui Wang, Zhongze Fang, Zhijie Yu, Gang Hu, Junhong Leng, Xilin Yang

Population and Public Health Science Faculty Publications

Aims: This study aimed to explore associations of mannan-binding lectin-associated serine protease (MASP) levels in early pregnancy with gestational diabetes mellitus (GDM). We also examined interactions of MASPs and deoxycholic acid (DCA)/glycoursodeoxycholic acid (GUDCA) for the GDM risk and whether the interactive effects if any on the GDM risk were mediated via lysophosphatidylcholine (LPC) 18:0. Materials and methods: A 1:1 case-control study (n = 414) nested in a prospective cohort of pregnant women was conducted in Tianjin, China. Binary conditional logistic regressions were performed to examine associations of MASPs with the GDM risk. Additive interaction measures were used to examine …

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The Rise Of Native Lordships At Pashash, A.D. 200–600, North Highlands Of Ancash, Peru, George F. Lau, Milton Luján Dávila, Jacob L. Bongers, David Chicoine Jan 2023

The Rise Of Native Lordships At Pashash, A.D. 200–600, North Highlands Of Ancash, Peru, George F. Lau, Milton Luján Dávila, Jacob L. Bongers, David Chicoine

Faculty Publications

This article examines the rise of native, segmentary lordships in the highlands of north-central Peru. It reports on new excavations and mapping at the seat of a prehispanic polity, Pashash (Recuay culture), a large hilltop center that developed after the collapse of Chavín civilization. Fieldwork revealed monumental constructions and two special activity contexts radiocarbon-dated to ca. a.d. 200–400: an offering area in a large palatial compound and a room-complex with chambers closed off and sealed with feasting refuse. Multiple lines of evidence help reconstruct a regional picture for the establishment of wealthy local elites. Cultural innovations explicitly link new leaders …

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