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Diagnoses For Leiognathus Lacepède 1802, Equula Cuvier 1815, Equulites Fowler 1904, Eubleekeria Fowler 1904, And A New Ponyfish Genus (Teleostei: Leiognathidae), Prosanta Chakrabarty, John S. Sparks Aug 2008

Diagnoses For Leiognathus Lacepède 1802, Equula Cuvier 1815, Equulites Fowler 1904, Eubleekeria Fowler 1904, And A New Ponyfish Genus (Teleostei: Leiognathidae), Prosanta Chakrabarty, John S. Sparks

Faculty Publications

Recent phylogenetic work on ponyfishes has delimited and revealed the interrelationships of major leiognathid clades. To begin to recognize a monophyletic taxonomy for Leiognathidae we diagnose, delimit, and describe a number of ponyfish genera to reflect our current knowledge of their phylogenetic history. Equula Cuvier, 1815, is resurrected from synonymy with Leiognathus Lacepède, 1802, and comprises E. fasciata and E longispinis. Members of Equula, the sister group to all other members of Leiognathidae, are large-bodied ponyfishes characterized by conspicuous round yellow blotches on the flank. The genus Leiognathus Lacepède, 1802, the sister group to the remaining members of Leiognathidae less …

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Estimating Species Trees Using Multiple-Allele Dna Sequence Data, Liang Liu, Dennis K. Pearl, Robb T. Brumfield, Scott V. Edwards Aug 2008

Estimating Species Trees Using Multiple-Allele Dna Sequence Data, Liang Liu, Dennis K. Pearl, Robb T. Brumfield, Scott V. Edwards

Faculty Publications

Several techniques, such as concatenation and consensus methods, are available for combining data from multiple loci to produce a single statement of phylogenetic relationships. However, when multiple alleles are sampled from individual species, it becomes more challenging to estimate relationships at the level of species, either because concatenation becomes inappropriate due to conflicts among individual gene trees, or because the species from which multiple alleles have been sampled may not form monophyletic groups in the estimated tree. We propose a Bayesian hierarchical model to reconstruct species trees from multiple-allele, multilocus sequence data, building on a recently proposed method for estimating …

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An Update Of The Field Guide To Louisiana Soil Classification (Bulletin #889), David C. Weindorf Aug 2008

An Update Of The Field Guide To Louisiana Soil Classification (Bulletin #889), David C. Weindorf

LSU AgCenter Bulletins

This field guide represents an update of work by Amacher et al. (1989), the original idea of which started with Dr. Bob Miller. The guide provides researchers and others interested in soils with a concise key to the classification of soils throughout Louisiana along with information on geology, climate, vegetation, etc.

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Viability And Fertilizing Capacity Of Cryopreserved Sperm From Three North American Acipenseriform Species: A Retrospective Study, Á Horváth, W. R. Wayman, J. C. Dean, B. Urbányi, T. R. Tiersch, S. D. Mims, D. Johnson, J. A. Jenkins Aug 2008

Viability And Fertilizing Capacity Of Cryopreserved Sperm From Three North American Acipenseriform Species: A Retrospective Study, Á Horváth, W. R. Wayman, J. C. Dean, B. Urbányi, T. R. Tiersch, S. D. Mims, D. Johnson, J. A. Jenkins

Faculty Publications

Populations of sturgeon across the globe are threatened due to unregulated harvest and habitat loss, and the status varies among species across North America. Ready access to viable and functional sperm would contribute to recovery programmes for these species. In this study, we examined the motility, viability (cell membrane integrity) of cryopreserved sperm from three North American acipenseriform species and fertilizing capacity. Milt samples were collected from captive shortnose sturgeon (Acipenser brevirostrum), wild paddlefish (Polyodon spathula) and pallid sturgeon (Scaphirhynchus albus) and cryopreserved using combinations of Modified Tsvetkova's (MT) extender, Original Tsvetkova's extender, and modified Hanks' balanced salt solution, along …

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Prevalence And Infection Load Dynamics Of Rickettsia Felis In Actively Feeding Cat Fleas, Kathryn E. Reif, Rhett W. Stout, Gretchen C. Henry, Lane D. Foil, Kevin R. Macaluso Jul 2008

Prevalence And Infection Load Dynamics Of Rickettsia Felis In Actively Feeding Cat Fleas, Kathryn E. Reif, Rhett W. Stout, Gretchen C. Henry, Lane D. Foil, Kevin R. Macaluso

Faculty Publications

Background: Rickettsia felis is a flea-associated rickettsial pathogen recurrently identified in both colonized and wild-caught cat fleas, Ctenocephalides felis. We hypothesized that within colonized fleas, the intimate relationship between R. felis and C. felis allows for the coordination of rickettsial replication and metabolically active periods during flea bloodmeal acquisition and oogenesis. Methodology/Principal Findings: a quantitative real-time PCR assay was developed to quantify R. felis in actively feeding R. felis-infected fleas. In three separate trials, fleas were allowed to feed on cats, and a mean of 3.9 × 106 R. felis 17-kDa gene copies was detected for each flea. A distinct …

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Size And Heterozygosity Influence Partner Selection In The Formosan Subterranean Termite, Claudia Husseneder, Dawn M. Simms Jul 2008

Size And Heterozygosity Influence Partner Selection In The Formosan Subterranean Termite, Claudia Husseneder, Dawn M. Simms

Faculty Publications

In monogamous species that exhibit extensive biparental investment, such as termites, both sexes are predicted to be selective when choosing a mate. Size-related traits are expected to be important in partner selection because the fat reserves of the colony founders sustain the incipient colony. Partner relatedness and heterozygosity determine the degree of inbreeding and genetic diversity within the colony and may thus also influence partner selection. To test these predictions, we investigated whether phenotypic and genetic traits influence mate choice and/or competitive advantage during pair formation of Formosan subterranean termites, Coptotermes formosanus (Isoptera: Rhinotermitidae). Pair formation in termites normally occurs …

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Herpes Simplex Virus Type-1(Hsv-1) Oncolytic And Highly Fusogenic Mutants Carrying The Nv1020 Genomic Deletion Effectively Inhibit Primary And Metastatic Tumors In Mice, Anna Israyelyan, Vladimir N. Chouljenko, Abolghasem Baghian, Andrew T. David, Michael T. Kearney, Konstantin G. Kousoulas Jul 2008

Herpes Simplex Virus Type-1(Hsv-1) Oncolytic And Highly Fusogenic Mutants Carrying The Nv1020 Genomic Deletion Effectively Inhibit Primary And Metastatic Tumors In Mice, Anna Israyelyan, Vladimir N. Chouljenko, Abolghasem Baghian, Andrew T. David, Michael T. Kearney, Konstantin G. Kousoulas

Faculty Publications

Background. The NV1020 oncolytic herpes simplex virus type-1 has shown significant promise for the treatment of many different types of tumors in experimental animal models and human trials. Previously, we described the construction and use of the NV1020-like virus OncSyn to treat human breast tumors implanted in nude mice. The syncytial mutation gKsyn1 (Ala-to-Val at position 40) was introduced into the OncSyn viral genome cloned into a bacterial artificial chromosome using double-red mutagenesis in E. coli to produce the OncdSyn virus carrying syncytial mutations in both gB(syn3) and gK(syn1). Results. The OncdSyn virus caused extensive virus-induced cell fusion in cell …

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Leaf Area Index Simulation In Soybean Grown Under Near-Optimal Conditions, T. D. Setiyono, A. Weiss, J. E. Specht, K. G. Cassman, A. Dobermann Jul 2008

Leaf Area Index Simulation In Soybean Grown Under Near-Optimal Conditions, T. D. Setiyono, A. Weiss, J. E. Specht, K. G. Cassman, A. Dobermann

Faculty Publications

Different approaches have been used to simulate leaf area index (LAI) in soybean (Glycine max L. Merr). Many of these approaches require genotype-specific calibration procedures. Studies modeling LAI dynamics under optimal growth conditions with yields close to the yield potential of soybean have remained scarce. A sink-driven approach was developed and evaluated for LAI simulation in soybean under near-optimal environments. The rate of change in expanding leaf area was simulated using the first derivative of a logistic function accounting for plant population density, air temperature, and water deficit. The rate of change in senescing leaf area was also simulated using …

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Two-Photon Imaging Of Spatially Extended Neuronal Network Dynamics With High Temporal Resolution., Lillis Kp, Eng A, White Ja, Mertz J Jul 2008

Two-Photon Imaging Of Spatially Extended Neuronal Network Dynamics With High Temporal Resolution., Lillis Kp, Eng A, White Ja, Mertz J

Faculty Publications

No abstract provided.

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Frequency-Dependent Glycinergic Inhibition Modulates Plasticity In Hippocampus., Keck T, Lillis Kp, Zhou Yd, White Ja Jul 2008

Frequency-Dependent Glycinergic Inhibition Modulates Plasticity In Hippocampus., Keck T, Lillis Kp, Zhou Yd, White Ja

Faculty Publications

No abstract provided.

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Cu/Zn Superoxide Dismutases In Developing Cotton Fibers: Evidence For An Extracellular Form, Hee Jin Kim, Naohiro Kato, Sunran Kim, Barbara Triplett Jul 2008

Cu/Zn Superoxide Dismutases In Developing Cotton Fibers: Evidence For An Extracellular Form, Hee Jin Kim, Naohiro Kato, Sunran Kim, Barbara Triplett

Faculty Publications

Hydrogen peroxide and other reactive oxygen species are important signaling molecules in diverse physiological processes. Previously, we discovered superoxide dismutase (SOD) activity in extracellular protein preparations from fiber-bearing cotton (Gossypium hirsutum L.) seeds. We show here, based on immunoreactivity, that the enzyme is a Cu/Zn-SOD (CSD). Immunogold localization shows that CSD localizes to secondary cell walls of developing cotton fibers. Five cotton CSD cDNAs were cloned from cotton fiber and classified into three subfamilies (Group 1: GhCSD1; Group 2: GhCSD2a and GhCSD2b; Group 3: GhCSD3 and GhCSD3s). Members of Group 1 and 2 are expressed throughout fiber development, but predominant …

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Louisiana Agriculture Summer, 2008, Lsu Agcenter Jul 2008

Louisiana Agriculture Summer, 2008, Lsu Agcenter

Louisiana Agriculture

No abstract provided.

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Effect Of Shilianhua Extract And Its Fractions On Body Weight Of Obese Mice, Jun Yin, Aamir Zuberi, Zhanguo Gao, Dong Liu, Zhijun Liu, William T. Cefalu, Jianping Ye Jul 2008

Effect Of Shilianhua Extract And Its Fractions On Body Weight Of Obese Mice, Jun Yin, Aamir Zuberi, Zhanguo Gao, Dong Liu, Zhijun Liu, William T. Cefalu, Jianping Ye

Faculty Publications

Five commercial botanical products (Shilianhua [SLH] tablets, Shiu Huo pills, Fenulyn, Bitter Melon, and Glucose Metabolic Support), available in the US market, with reported claims for regulation of metabolism were screened for their effect on body weight gain in high-fat diet-induced obese mice. Pilot results suggested that SLH tablets attenuated body weight gain, whereas Shiu Huo pills and Fenulyn tended to promote weight gain in the mice on the high-fat diet. To investigate the bioactive components in the SLH tablet, the wild SLH plant (Sinocrassula indica Berge) was collected from China and used to make a variety of extracts including …

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Botanicals As Epigenetic Modulators For Mechanisms Contributing To Development Of Metabolic Syndrome, Heather Kirk, William T. Cefalu, David Ribnicky, Zhijun Liu, Kenneth J. Eilertsen Jul 2008

Botanicals As Epigenetic Modulators For Mechanisms Contributing To Development Of Metabolic Syndrome, Heather Kirk, William T. Cefalu, David Ribnicky, Zhijun Liu, Kenneth J. Eilertsen

Faculty Publications

Epigenetics refers to heritable changes in gene expression that are not attributable to changes in DNA sequence and impacts many areas of applied and basic biology including developmental biology, gene therapy, somatic cell nuclear transfer, somatic cell reprogramming, and stem cell biology. Epigenetic changes are known to contribute to aging in addition to multiple disease states. Epigenetic changes can be influenced by environmental factors that in turn can be inherited by daughter cells during cell division and can also be inherited through the germ line. Thus, it is intriguing to consider that epigenetics, in general, may play a role in …

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Multidimensional Fluorescence Microscopy Of Multiple Organelles In Arabidopsis Seedlings, Naohiro Kato, Dexter Reynolds, Matthew L. Brown, Marietta Boisdore, Yukichi Fujikawa, Andrea Morales, Lee A. Meisel Jun 2008

Multidimensional Fluorescence Microscopy Of Multiple Organelles In Arabidopsis Seedlings, Naohiro Kato, Dexter Reynolds, Matthew L. Brown, Marietta Boisdore, Yukichi Fujikawa, Andrea Morales, Lee A. Meisel

Faculty Publications

Background. The isolation of green fluorescent protein (GFP) and the development of spectral variants over the past decade have begun to reveal the dynamic nature of protein trafficking and organelle motility. In planta analyses of this dynamic process have typically been limited to only two organelles or proteins at a time in only a few cell types. Results. We generated a transgenic Arabidopsis plant that contains four spectrally different fluorescent proteins. Nuclei, plastids, mitochondria and plasma membranes were genetically tagged with cyan, red, yellow and green fluorescent proteins, respectively. In addition, methods to track nuclei, mitochondria and chloroplasts and quantify …

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Mangrove Production And Carbon Sinks: A Revision Of Global Budget Estimates, Steven Bouillon, Alberto V. Borges, Edward Castañeda-Moya, Karen Diele, Thorsten Dittmar, Norman C. Duke, Erik Kristensen, Shing Y. Lee, Cyril Marchand, Jack J. Middelburg, Victor H. Rivera-Monroy, Thomas J. Smith, Robert R. Twilley Jun 2008

Mangrove Production And Carbon Sinks: A Revision Of Global Budget Estimates, Steven Bouillon, Alberto V. Borges, Edward Castañeda-Moya, Karen Diele, Thorsten Dittmar, Norman C. Duke, Erik Kristensen, Shing Y. Lee, Cyril Marchand, Jack J. Middelburg, Victor H. Rivera-Monroy, Thomas J. Smith, Robert R. Twilley

Faculty Publications

Mangrove forests are highly productive but globally threatened coastal ecosystems, whose role in the carbon budget of the coastal zone has long been debated. Here we provide a comprehensive synthesis of the available data on carbon fluxes in mangrove ecosystems. A reassessment of global mangrove primary production from the literature results in a conservative estimate of ∼-218 ± 72 Tg C a-1. When using the best available estimates of various carbon sinks (organic carbon export, sediment burial, and mineralization), it appears that >50% of the carbon fixed by mangrove vegetation is unaccounted for. This unaccounted carbon sink is …

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Evaluation Of Different Insecticides And Fabric Types For Development Of Treated Targets For Stable Fly (Diptera: Muscidae) Control, Jerome A. Hogsette, Alyce Nalli, Lane D. Foil Jun 2008

Evaluation Of Different Insecticides And Fabric Types For Development Of Treated Targets For Stable Fly (Diptera: Muscidae) Control, Jerome A. Hogsette, Alyce Nalli, Lane D. Foil

Faculty Publications

Stable fly, Stomoxys calcitrans (L.) (Diptera: Muscidae), once only a pest of pastured cattle, has become a serious pest of range cattle in the United States. Because of the difficulties associated with stable fly management under range conditions, a pesticide-impregnated cloth target is being developed as a management tool. We conducted studies to determine the influence of weather, time, fabric type, insecticide type, and insecticide concentration on the mortality of stable flies from a susceptible laboratory colony exposed for 30 s to treated cloth targets. We found that 100% of the flies exposed to trigger (Trigger-Royal Box, 65% polyester and …

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Identification Of Rickettsia Felis In The Salivary Glands Of Cat Fleas, Kevin R. Macaluso, Walairat Pornwiroon, Vsevolod L. Popov, Lane D. Foil Jun 2008

Identification Of Rickettsia Felis In The Salivary Glands Of Cat Fleas, Kevin R. Macaluso, Walairat Pornwiroon, Vsevolod L. Popov, Lane D. Foil

Faculty Publications

Rickettsia felis, a flea-associated rickettsial pathogen, has been identified in many tissues, including the digestive and reproductive tissues, within the cat flea, Ctenocephalides felis. We utilized transmission electron microscopy and polymerase chain reaction to identify R. felis in the salivary glands of fed fleas and further define the distribution of R. felis within the arthropod host. We identified Rickettsia-like organisms in salivary glands using electron microscopy. Sequence analysis of portions of the Rickettsia genus-specific 17-kDa antigen gene and R. felis plasmid confirmed the morphological identification of R. felis in cat flea salivary glands. This is the first report of R. …

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Mitochondria In Energy-Limited States: Mechanisms That Blunt The Signaling Of Cell Death, Steven C. Hand, Michael A. Menze Jun 2008

Mitochondria In Energy-Limited States: Mechanisms That Blunt The Signaling Of Cell Death, Steven C. Hand, Michael A. Menze

Faculty Publications

Cellular conditions experienced during energy-limited states - elevated calcium, shifts in cellular adenylate status, compromised mitochondrial membrane potential - are precisely those that trigger, at least in mammals, the mitochondrion to initiate opening of the permeability transition pore, to assemble additional protein release channels, and to release pro-apoptotic factors. These proapototic factors in turn activate initiator and executer caspases. How is activation of mitochondria-based pathways for the signaling of apoptotic and necrotic cell death avoided under conditions of hypoxia, anoxia, diapause, estivation and anhydrobiosis? Functional trade-offs in environmental tolerance may have occurred in parallel with the evolution of diversified pathways …

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Preparation Of Botanical Samples For Biomedical Research, Zhijun Liu Jun 2008

Preparation Of Botanical Samples For Biomedical Research, Zhijun Liu

Faculty Publications

Plants are chemical storehouses, a fact which has driven countless multidisciplinary quests for bioactive compounds. As the very first step of botanical research, the whole desire is to find "hit" plants with specific bioactivities. It is logical to use some strategies that can maximize the chances of finding these "hits" with limited time and resources. In addition to selecting the right plants for screening, how the plant extracts are prepared can also influence the bioactivity screening outcomes. An extract from the same plant material can be quite different in chemical composition having different preparations. Because of the complex mixture nature …

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Seismic Reflection Evidence For A Dangerous Grounds Miniplate: No Extrusion Origin For The South China Sea, Peter Clift, Gwang H. Lee, Nguyan Anh Duc, Udo Barckhausen, Hoang Van Long, Sun Zhen Jun 2008

Seismic Reflection Evidence For A Dangerous Grounds Miniplate: No Extrusion Origin For The South China Sea, Peter Clift, Gwang H. Lee, Nguyan Anh Duc, Udo Barckhausen, Hoang Van Long, Sun Zhen

Faculty Publications

The collision of India and Asia has caused large strike-slip faults to form in east Asia, resulting in the "extrusion" of crustal blocks toward the southeast since the Eocene as a result of the indentation of rigid India into Asia. It has been suggested that the South China Sea opened as a result of relative motion between a rigid Indochina (Sundaland) block and China. Alternative models propose that riffing and seafloor spreading were driven by trench forces to the south. We test these competing models by analysis of seismic reflection profiles across the boundary between Sundaland and the southern rifted …

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Neuroprotection Via Matrix-Trophic Coupling Between Cerebral Endothelial Cells And Neurons, Shuzhen Guo, Woo Jean Kim, Josephine Lok, Sun Ryung Lee, Elaine Besancon, Bing Hao Luo, Monique F. Stins, Xiaoying Wang, Shoukat Dedhar, Eng H. Lo May 2008

Neuroprotection Via Matrix-Trophic Coupling Between Cerebral Endothelial Cells And Neurons, Shuzhen Guo, Woo Jean Kim, Josephine Lok, Sun Ryung Lee, Elaine Besancon, Bing Hao Luo, Monique F. Stins, Xiaoying Wang, Shoukat Dedhar, Eng H. Lo

Faculty Publications

The neurovascular unit is an emerging concept that emphasizes homeostatic interactions between endothelium and cerebral parenchyma. Here, we show that cerebral endothelium are not just inert tubes for delivering blood, but they also secrete trophic factors that can be directly neuroprotective. Conditioned media from cerebral endothelial cells broadly protects neurons against oxygen-glucose deprivation, oxidative damage, endoplasmic reticulum stress, hypoxia, and amyloid neurotoxicity. This phenomenon is largely mediated by endothelial-produced brain-derived neurotrophic factor (BDNF) because filtering endothelial-conditioned media with TrkB-Fc eliminates the neuroprotective effect. Endothelial production of BDNF is sustained by β-1 integrin and integrin-linked kinase (ILK) signaling. Noncytotoxic levels of …

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Genome Analysis Of The Platypus Reveals Unique Signatures Of Evolution, Wesley C. Warren, La Deana W. Hillier, Jennifer A. Marshall Graves, Ewan Birney, Chris P. Ponting, Frank Grützner, Katherine Belov, Webb Miller, Laura Clarke, Asif T. Chinwalla, Shiaw Pyng Yang, Andreas Heger, Devin P. Locke, Pat Miethke, Paul D. Waters, Frédéric Veyrunes, Lucinda Fulton, Bob Fulton, Tina Graves, John Wallis, Xose S. Puente, Carlos López-Otín, Gonzalo R. Ordóñez, Evan E. Eichler, Lin Chen, Ze Cheng, Janine E. Deakin, Amber Alsop, Katherine Thompson, Patrick Kirby, Anthony T. Papenfuss, Matthew J. Wakefield, Tsviya Olender, Doron Lancet May 2008

Genome Analysis Of The Platypus Reveals Unique Signatures Of Evolution, Wesley C. Warren, La Deana W. Hillier, Jennifer A. Marshall Graves, Ewan Birney, Chris P. Ponting, Frank Grützner, Katherine Belov, Webb Miller, Laura Clarke, Asif T. Chinwalla, Shiaw Pyng Yang, Andreas Heger, Devin P. Locke, Pat Miethke, Paul D. Waters, Frédéric Veyrunes, Lucinda Fulton, Bob Fulton, Tina Graves, John Wallis, Xose S. Puente, Carlos López-Otín, Gonzalo R. Ordóñez, Evan E. Eichler, Lin Chen, Ze Cheng, Janine E. Deakin, Amber Alsop, Katherine Thompson, Patrick Kirby, Anthony T. Papenfuss, Matthew J. Wakefield, Tsviya Olender, Doron Lancet

Faculty Publications

We present a draft genome sequence of the platypus, Ornithorhynchus anatinus. This monotreme exhibits a fascinating combination of reptilian and mammalian characters. For example, platypuses have a coat of fur adapted to an aquatic lifestyle; platypus females lactate, yet lay eggs; and males are equipped with venom similar to that of reptiles. Analysis of the first monotreme genome aligned these features with genetic innovations. We find that reptile and platypus venom proteins have been co-opted independently from the same gene families; milk protein genes are conserved despite platypuses laying eggs; and immune gene family expansions are directly related to platypus …

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Effect Of Epigenetic Modifications Of Donor Somatic Cells On The Subsequent Chromatin Remodeling Of Cloned Bovine Embryos, Angelica M. Giraldo, Darin A. Hylan, Casey B. Ballard, Megan N. Purpera, Todd D. Vaught, John W. Lynn, Robert A. Godke, Kenneth R. Bondioli May 2008

Effect Of Epigenetic Modifications Of Donor Somatic Cells On The Subsequent Chromatin Remodeling Of Cloned Bovine Embryos, Angelica M. Giraldo, Darin A. Hylan, Casey B. Ballard, Megan N. Purpera, Todd D. Vaught, John W. Lynn, Robert A. Godke, Kenneth R. Bondioli

Faculty Publications

Evidence indicates that failure of nuclear transfer (NT) embryos to develop normally can be attributed, at least partially, to the use of differentiated cells as the donor karyoplast. Blastocyst production and development to term of cloned embryos has been hypothesized to differ between population doublings of the same cell line as a consequence of changes in the levels of DNA methyltransferase 1 (DNMT1) and methylated DNA during in vitro culture. The objective of this study was to determine embryo production, developmental potential, and gene expression patterns of prehatched and posthatched embryos generated using donor cells with different levels of DNMT1 …

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Fear And Loathing In Contemporary British Art: A Critical Analysis Of The Banksy Phenomenon, Courtney Spring May 2008

Fear And Loathing In Contemporary British Art: A Critical Analysis Of The Banksy Phenomenon, Courtney Spring

Honors Capstones

No abstract provided.

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“Solidarity And Solidarność: A Search For The Person In Community”, Elizabeth Mary Johnson May 2008

“Solidarity And Solidarność: A Search For The Person In Community”, Elizabeth Mary Johnson

Honors Capstones

No abstract provided.

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Post-Allergen Challenge Inhibition Of Poly(Adp-Ribose) Polymerase Harbors Therapeutic Potential For Treatment Of Allergic Airway Inflammation, A. S. Naura, C. P. Hans, M. Zerfaoui, D. You, S. A. Cormier, M. Oumouna, A. H. Boulares May 2008

Post-Allergen Challenge Inhibition Of Poly(Adp-Ribose) Polymerase Harbors Therapeutic Potential For Treatment Of Allergic Airway Inflammation, A. S. Naura, C. P. Hans, M. Zerfaoui, D. You, S. A. Cormier, M. Oumouna, A. H. Boulares

Faculty Publications

Background: Identifying therapeutic drugs that block the release or effects of T-helper type 2 (Th2) cytokines after allergen exposure is an important goal for the treatment of allergic inflammatory diseases including asthma. We recently showed, using a murine model of allergic airway inflammation, that poly(ADP-ribose) polymerase (PARP) plays an important role in the pathogenesis of asthma-related lung inflammation. PARP inhibition, by single injection of a novel inhibitor, thieno[2,3-c]isoquinolin-5-one (TIQ-A), before ovalbumin (OVA) challenge, prevented airway eosinophilia in C57BL/6 mice with concomitant suppression of Th2 cytokine production and mucus secretion. Objective: To evaluate the efficacy of the drug when it is …

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Culture-Independent Identification Of Gut Bacteria In Fourth-Instar Red Imported Fire Ant, Solenopsis Invicta Buren, Larvae, Albert H. Lee, Claudia Husseneder, Linda Hooper-Bùi May 2008

Culture-Independent Identification Of Gut Bacteria In Fourth-Instar Red Imported Fire Ant, Solenopsis Invicta Buren, Larvae, Albert H. Lee, Claudia Husseneder, Linda Hooper-Bùi

Faculty Publications

Red imported fire ants (RIFA), Solenopsis invicta Buren, are medical, urban, and agricultural pests from South America. They are successful invaders due to their preference for disturbed habitats, high reproductive rates, and the ability to feed on a wide variety of food items (omnivorous). Fourth-instar larvae are used by the colony to digest solid food and then regurgitate it for consumption by workers and queens. Larvae are an ideal source of investigations of endosymbiotic bacteria possibly involved in nutrient distributions. Our study utilized 16S rDNA sequencing to describe the composition of the bacterial community in fourth-instar ant larvae in order …

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The Power Of Language: In Politics, Genocide, And Politicide, Heather Rademacher May 2008

The Power Of Language: In Politics, Genocide, And Politicide, Heather Rademacher

Honors Capstones

No abstract provided.

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The Sustenance Of Sound: A Short Story Sequence, Allison Rae Eskind May 2008

The Sustenance Of Sound: A Short Story Sequence, Allison Rae Eskind

Honors Capstones

No abstract provided.

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