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Miocene Herpetofaunas From The Central Gulf Coast Usa: Their Paleoecology, Biogeography, And Biostratigraphy, Michael John Williams Jan 2009

Miocene Herpetofaunas From The Central Gulf Coast Usa: Their Paleoecology, Biogeography, And Biostratigraphy, Michael John Williams

LSU Doctoral Dissertations

The late Barstovian Fort Polk herpetofauna represents the most diverse herpetofauna on the Gulf Coast, USA, and includes 15 genera from ten families. The herpetofaunal composition of Fort Polk and Miocene east Texas localities is similar enough to Great Plains localities that they are all considered to be one biogeographical province during the Barstovian. The use of ternary diagrams, ratios of herpetological elements to kg matrix screened, and natricine-colubrine indices, has allowed determining the wetness of the Fort Polk sites. Development of a composite stratigraphic section for North American fossil snakes has allowed recognition of two extinctions of fossil snakes …

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Creep Behavior Of Natural Fiber Reinforced Polymer Composites, Yanjun Xu Jan 2009

Creep Behavior Of Natural Fiber Reinforced Polymer Composites, Yanjun Xu

LSU Doctoral Dissertations

Creep behavior of natural fiber/polymer composites (NFPCs) was studied in response to the increasing application of this material as structural building products. Factors that influence creep behavior of the composites were investigated by analyzing creep curves of several different NFPC systems, which were designed for overall performance of the composites. Among different models, the 4-element Burgers type was mostly used for quantitative characterization of the creep curves to compare the properties of different composites. The parameters from the 4-element Burgers model were easily interpretable due to their physical meanings. Generalized Burgers models provided better fit by introducing extra Kelvin units, …

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Arthropod And Vertebrate Determinants For Horizontal Transmission Of Rickettsia Felis, Kathryn Elizabeth Reif Jan 2009

Arthropod And Vertebrate Determinants For Horizontal Transmission Of Rickettsia Felis, Kathryn Elizabeth Reif

LSU Doctoral Dissertations

Rickettsia felis is a gram-negative bacterium predominantly described in the cat flea, Ctenocephalides felis. Since first described in 1990 in a commercial cat flea colony in the United States, R. felis has been detected in numerous arthropod species in 28 countries around the world. Additionally, as the etiologic agent of flea-borne rickettsiosis, R. felis can cause disease in humans, with patients presenting with clinical symptoms typical of rickettsial diseases including: fever, headache, and myalgia. Transmission of R. felis within flea colonies is predominantly via vertical (transovarial and transstadial) transmission and mechanisms of horizontal transmission are undescribed. Studies are needed to …

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The Agricultural Industry As Percieved By Members Of The General Public Of Louisiana, Julie Baker Richard Jan 2009

The Agricultural Industry As Percieved By Members Of The General Public Of Louisiana, Julie Baker Richard

LSU Doctoral Dissertations

The purpose of this study was to determine the knowledge and perceptions of the animal, plant, environmental, and food sciences by the adult residents of Louisiana. This study was conducted using a survey research design. This survey utilized random telephone dialing techniques in order to survey 547 residents of Louisiana. The survey instrument consisted of fifty-five questions divided into three sections: demographic characteristics, agriculture knowledge, and perception of agriculture. The overall mean agriculture knowledge score of adult residents of Louisiana for the twenty items included in the survey instrument equaled 13.60 (SD = 2.743) or 68%. Perceptions of agriculture results …

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Ecological Risk Models For Visceral Leishmaniais [Sic] In Bahia, Brazil And Diagnosis Of Trypanosoma Cruzi Infection In Dogs In South Central Louisiana, Prixia Nieto Jan 2009

Ecological Risk Models For Visceral Leishmaniais [Sic] In Bahia, Brazil And Diagnosis Of Trypanosoma Cruzi Infection In Dogs In South Central Louisiana, Prixia Nieto

LSU Doctoral Dissertations

Three predictive models were developed within a geographic information system using earth observing satellite remote sensing (RS), the Genetic Algorithm for Rule-Set Prediction (GARP) and the growing degree day-water budget (GDD-WB) concept to predict the distribution and potential risk of visceral leishmaniasis (VL) in the State of Bahia, Brazil. The objective was to define the environmental suitability of the disease as well as to obtain a deeper understanding of the eco-epidemiology of VL by associating environmental and climatic variables with disease prevalence. The RS, the GARP model and the GDD-WB model, using different analysis approaches and with the same human …

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Three Essays On Environmental Issues Associated With Broiler Production In Louisiana, Nirmala Adhikari Devkota Jan 2009

Three Essays On Environmental Issues Associated With Broiler Production In Louisiana, Nirmala Adhikari Devkota

LSU Doctoral Dissertations

The increasing trends of integrated and concentrated broiler production results in a serious threat to environment through excessive litter production and lack of its proper disposal. Production concentration in limited area is a major source of surface as well as ground water pollution. Nonpoint source pollution from broiler litter applied on land remains a major concern in Louisiana and elsewhere in Southeastern USA. This study examines alternative approaches to reduce pollution originating from broiler production. First, I evaluate why some producers adopt BMP faster than others and what kind of factors affect the time to adoption decision. The duration model …

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Characterization Of Porcine Adipose Tissue-Derived Stem Cells, Kellie J. Williams Jan 2009

Characterization Of Porcine Adipose Tissue-Derived Stem Cells, Kellie J. Williams

LSU Doctoral Dissertations

Nuclear transfer (NT) results in low success rates and research has reported problems with the welfare of cloned animals produced. Evidence suggests the use of a less differentiated donor cell, such as a stem cell, may lead to an increase in the efficiency of the NT procedure. Stem cell characteristics must be clearly defined in order to isolate, identify and optimally culture potential donor cells. Stem cell characteristics such as self-renewal and differentiation have not been identified in stem cells from porcine adipose tissue, an easily attainable tissue resource. The phenotypic profile of cell surface proteins and chromosomal stability of …

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Assessing The Development Of High School Chemistry Students' Conceptual And Visual Understanding Of Dimensional Analysis Via Supplemental Use Of A Proprietary Interactive Software Program, Jennifer Tennille Pinder Ellis Jan 2009

Assessing The Development Of High School Chemistry Students' Conceptual And Visual Understanding Of Dimensional Analysis Via Supplemental Use Of A Proprietary Interactive Software Program, Jennifer Tennille Pinder Ellis

LSU Doctoral Dissertations

This study was designed to evaluate the effects of the proprietary science education software, “Conversionoes,” on students' conceptual and visual understanding of dimensional analysis. The participants in the study were high school general chemistry students enrolled in two public high schools with different demographics (School A and School B) in the Chattanooga, Tennessee, metropolitan area. A mixed methods design was used in the data collection and analysis to provide a holistic view of the impact of the software on student learning, via a value-added design. The resulting qualitative and quantitative data indicated that the Conversionoes software enhanced the treatment groups’ …

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The Interactive Effects Of Phosporus And Calcium On Phosphorus Requirement, Utilization, And Phytase Efficacy In Poultry, Syrena Powell Jan 2009

The Interactive Effects Of Phosporus And Calcium On Phosphorus Requirement, Utilization, And Phytase Efficacy In Poultry, Syrena Powell

LSU Doctoral Dissertations

This research was conducted with broilers to investigate the interactive effects of P and Ca on P requirement, digestibility, utilization, and phytase efficacy. Each treatment had a minimum of 6 replications. One experiment with 3 trials was conducted to identify the nonphytate P (nPP) requirement of 0 to 14 d old broilers. The nPP levels fed ranged from 0.30 to 0.60% with a Ca:nPP of 2.22:1 or 1.9:1. Requirement estimates for 0 to 14 d ranged from 0.52 to 0.60% nPP. One experiment with 2 trials was conducted to identify the nPP requirement of 14 to 28 d old broilers. …

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Peptide Targeting Of Platinum Anti-Cancer Drug And Synthesis Of Water Soluble Monofunctional Pt(Ii) Complexes Useful For Biological Labeling, Margaret W. Ndinguri Jan 2009

Peptide Targeting Of Platinum Anti-Cancer Drug And Synthesis Of Water Soluble Monofunctional Pt(Ii) Complexes Useful For Biological Labeling, Margaret W. Ndinguri

LSU Doctoral Dissertations

Platinum has been used as an inorganic medicinal agent with various applications such as anti cancer agents. Several new targeted Pt(II) conjugates were synthesized having the NGR and LHRH targeting motif. The platinum conjugates bearing the NGR motif revealed selective delivery and destruction of cancer cells that had CD13 receptors compared to untargeted carboplatin drug. The development of targeted chemotherapeutic has opened a new approach for efficient delivery of antitumor toxins with minimal exposure to normal cells. Several peptide sequences are known to have the ability to target tumors, for instance NGR motif which home specifically in solid tumors and …

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Production And Application Of Antibodies Produced Against The Flagella And Hemolysin Of Vibrio Parahaemolyticus, Shreya Datta Jan 2009

Production And Application Of Antibodies Produced Against The Flagella And Hemolysin Of Vibrio Parahaemolyticus, Shreya Datta

LSU Doctoral Dissertations

Vibrio parahaemolyticus is a marine bacterium which is the leading cause of bacterial gastroenteritis due to consumption of raw or undercooked bivalve molluscan shellfish in United States and is considered an important seafood-borne pathogen throughout the world. The conventional methods for enumerating this bacteria from seafood is laborious and time consuming, hence the objective of our study was to develop antibody based method which would be sensitive, user-friendly and less time consuming to detect and enumerate Vibrio parahaemolyticus from oysters. In order to condense time and material two rapid and specific antibody based test methods were developed. In the first …

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Temperature Impact On Nitrification And Bacterial Growth Kinetics In Acclimating Recirculating Aquaculture Systems Biofilters, Milton Maada-Gomoh Saidu Jan 2009

Temperature Impact On Nitrification And Bacterial Growth Kinetics In Acclimating Recirculating Aquaculture Systems Biofilters, Milton Maada-Gomoh Saidu

LSU Doctoral Dissertations

This project assessed short-term temperature effects on total ammonia nitrogen (TAN) utilization rates in a batch laboratory-scale recirculating system. The tank system was designed for experiments on short term steady state and diurnal temperatures. A set of numerical models was developed to simulate observed results. The performance of the biofilters was determined with three tank replicates at fixed temperatures of 13, 20 and 300C; and at diurnal transient (sinusoidal) temperature regimes of (20 ± 30C; 30 ± 30C). Ammonia utilization rates and biofilter performance for beads acclimated at different temperatures regimes separated and mixed were also determined. Total ammonia utilization …

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The Effect Of Rhythm-Based Computer-Assisted Music Instruction Designed For Individual Learning Style Preferences On The Learning Of Preservice Elementary Education Majors, Judy Arnette Guilbeaux-James Jan 2009

The Effect Of Rhythm-Based Computer-Assisted Music Instruction Designed For Individual Learning Style Preferences On The Learning Of Preservice Elementary Education Majors, Judy Arnette Guilbeaux-James

LSU Doctoral Dissertations

This study investigated the effect of rhythm based computer-assisted music instruction designed for individual learning style preferences. Participants were undergraduate preservice elementary education majors (N = 82) enrolled in Fundamentals of Music. The Perceptual Learning Style Preferences Survey and the Diablo Valley College Learning Style Survey were used to measure learning preferences. Two content knowledge assessments were administered as pre and posttest: (a) Music Achievement Test (MAT) Test 2-Part 3-Auditory and Visual Discrimination subtest b and (b) Researcher-Developed Rhythm Test (RDRT). Researcher-developed software programs were constructed, teaching participants the basic elements of rhythm based on learning style preferences. Forty-three of …

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An Integrated Agent-Based Microsimulation Model For Hurricane Evacuation In New Orleans, Wei Liang Jan 2009

An Integrated Agent-Based Microsimulation Model For Hurricane Evacuation In New Orleans, Wei Liang

LSU Doctoral Dissertations

Mass evacuation of urban areas due to hurricanes is a critical problem that requires extensive basic and applied research. Knowing the accurate evacuation time needed for the entire region in advance such that the evacuation order can be issued on a timely basis is crucial for the officials. Microsimulation modeling, which focuses on the characteristics of individual motorists and travel behavior, has been used widely in traffic simulation as it can lead to the most accurate result. However, because detailed driver response modeling and path processing must be incorporated, vehicle-based microscopic models have always been used only to simulate small …

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Dna Methylation Analysis And Identification Of A Novel Antisense Transcript In The Peg3 Imprinted Domain, Jennifer Marian Huang Jan 2009

Dna Methylation Analysis And Identification Of A Novel Antisense Transcript In The Peg3 Imprinted Domain, Jennifer Marian Huang

LSU Doctoral Dissertations

Genomic imprinting is a process that leads to the silencing of one allele of a gene in a parent of origin specific manner. Genes that are involved in this process are often regulated in clusters, one of which is the Peg3 (Paternally expressed gene 3) imprinted domain. We investigated this region for both CpG islands and long antisense transcripts, two common features of imprinted gene clusters. First, we performed a systematic survey of DNA methylation status of the CpG islands in this region of the mouse, cow, and human genomes. We identified two previously unreported differentially methylated regions (DMR): one …

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Examining The Influence Of Popular Music And Poetry Therapy On The Development Of Therapeutic Factors In Groups With At-Risk Adolsecents, Leah Olson-Mcbride Jan 2009

Examining The Influence Of Popular Music And Poetry Therapy On The Development Of Therapeutic Factors In Groups With At-Risk Adolsecents, Leah Olson-Mcbride

LSU Doctoral Dissertations

In this study, music and poetry were combined to form a client-centered therapeutic approach to group psychotherapy with at-risk youth that encourages connection, communication, and self-expression. This specialized poetry therapy intervention utilizes popular music and creative writing activities to facilitate group discussion about feelings, life experiences, goals, and values. The purpose of this research was to examine the impact of such an intervention on group formation and development, with a specific focus on the development of factors, such as self-disclosure, which contribute to therapeutic change over the course of the intervention. A multiple embedded case study approach was utilized to …

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Assessing Linkages Between Petroleum Platforms And Pelagic Fishes Using Telemetry With Emphasis On Blue Runner (Caranx Crysos), Harmon Brown Jan 2009

Assessing Linkages Between Petroleum Platforms And Pelagic Fishes Using Telemetry With Emphasis On Blue Runner (Caranx Crysos), Harmon Brown

LSU Doctoral Dissertations

Petroleum platforms number greater than 4,200 in the Gulf of Mexico and Caranx crysos (blue runner) is one of the most abundant fish species around these platforms. Forty-six blue runner were tagged with acoustical transmitters in August 2005, though the study was terminated prematurely due to the impending arrival of Hurricane Katrina. Nineteen blue runner were tagged in September 2006 and tracked for up to two months. Blue runner exhibited limited site fidelity around the platforms in 2005. The home range of twenty-three blue runner was calculated in 2005. A significant difference was found between the fork length of the …

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The Feasibility Of Using Select Landscape Species For Phytoremediation Of Cumene And 4-Cumylphenol Contaminated Groundwater, Kathryn Karsh Fontenot Jan 2009

The Feasibility Of Using Select Landscape Species For Phytoremediation Of Cumene And 4-Cumylphenol Contaminated Groundwater, Kathryn Karsh Fontenot

LSU Doctoral Dissertations

Chemical manufactures are often associated with a negative publicity due to chemical spills that can cause human health problems and environmental pollution. Innovative methods such as phytoremediation in lieu of traditional remediation methods are being researched to determine environmentally friendly options for remediation. Phytoremediation was studied as an alternative remediation method for removal of chemicals in a contaminated groundwater plume in Louisiana. The main constituents of concern in the plume were cumene and 4-cumylphenol. Two pilot phytotoxicity studies were funded to determine an optimum tree species for removal and control of the constituents of concern. A greenhouse and hydroponic system …

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Detection Of Stress Biomarkers In Sperm, Embryonic, And Early Larval States Of Aquatic Invertebrates Following Pesticide Exposure, Karen Perry Favret Jan 2009

Detection Of Stress Biomarkers In Sperm, Embryonic, And Early Larval States Of Aquatic Invertebrates Following Pesticide Exposure, Karen Perry Favret

LSU Doctoral Dissertations

Current regulatory testing provides the basis for determining acceptable levels of pollutants in the environment, yet these acceptable levels of contaminants have resulted in undesirable consequences to organisms. The purpose of this dissertation was to test the hypothesis that biomarkers of cellular stress could be detected from sub-lethal exposure to pesticides in sperm and early life stages of broadcast spawning invertebrates. Exposures were conducted on oyster (Crassostrea virginica), mussel (Mytilus galloprovincialis and Dreissena polymorpha), and sea urchin (Lytechinus variegatus) embryos and larvae for 4 and 24 h to Bayluscide® and Roundup®. DNA fragmentation, a characteristic of apoptotic cells, was detected …

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Function Of Isca In Biogenesis Of Iron-Sulfur Clusters And Repair Of No-Modified Iron-Sulfur Proteins, Juanjuan Yang Jan 2009

Function Of Isca In Biogenesis Of Iron-Sulfur Clusters And Repair Of No-Modified Iron-Sulfur Proteins, Juanjuan Yang

LSU Doctoral Dissertations

Iron-sulfur (Fe-S) clusters are ubiquitous prosthetic groups that function in diverse fundamental life processes. However, the biogenesis of iron-sulfur clusters in vivo is not a spontaneous process. Previous studies indicated that Fe-S clusters maybe synthesized by three major systems: the Nif, the ISC, and the SUF systems. Among these three systems, IscU, NifU are the scaffold proteins for the Fe-S clusters assembly. IscA and its paralog, SufA are proposed as an alternative iron-sulfur cluster assembly scaffold proteins. The cysteine desulfurases: IscS, NifS and SufS catalyze desulfurization of the L-cysteine and provide sulfide for Fe-S clusters assembly. However, the iron donor …

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Characterization Of The 'Glutamate Effect' On The Solution Thermodynamics And Function Of The Large Fragments Of The Type I Dna Polymerases From E.Coli And T.Aquaticus, Daniel J. Deredge Jan 2009

Characterization Of The 'Glutamate Effect' On The Solution Thermodynamics And Function Of The Large Fragments Of The Type I Dna Polymerases From E.Coli And T.Aquaticus, Daniel J. Deredge

LSU Doctoral Dissertations

In this study, it is shown that the large fragments of the type I DNA polymerase from E.coli (Klenow) and T.aquaticus (Klentaq) display enhanced DNA binding affinity in glutamate vs. chloride. Across the relatively narrow salt concentration ranges often used to obtain salt linkage data, Klenow also displays an apparently decreased linked ion released (¦¤nions) in Kglutamate vs. KCl while Klentaq does not display such an effect. The osmotic stress technique reveals that Klenow and Klentaq DNA binding is associated with the release of ~500 to 600 waters in KCl. For both proteins, replacing chloride with glutamate results …

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Distribution, Diversity And Ecology Of Aerobic Carbon Monoxide-Oxidizing Bacteria In Hawaiian Volcanic Deposits, Carolyn Frances Weber Jan 2009

Distribution, Diversity And Ecology Of Aerobic Carbon Monoxide-Oxidizing Bacteria In Hawaiian Volcanic Deposits, Carolyn Frances Weber

LSU Doctoral Dissertations

Carbon monoxide-oxidizing bacteria are among the first colonists of recently formed volcanic deposits despite environmental conditions that challenge their survival, such as oscillating water regimes and lack of endogenous sources of organic carbon and nitrogen. Activity assessments and molecular surveys of the coxL gene (large subunit carbon monoxide dehydrogenase) across a vegetation gradient on a 1959 volcanic deposit on Kilauea Volcano (Hawai’i) indicated that CO-oxidizing communities continue to expand, diversify and remain competitive during ecosystem development. Distinct compositional shifts occurred across the gradient with Firmicutes-like coxL sequences dominating clone libraries from unvegetated sites (Bare) and Proteobacteria coxL sequences dominating libraries …

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Physical And Chemical Factors Controlling Carbon Gas Emissions And Organic Matter Transformation In Coastal Wetlands, Syam Kumar Dodla Jan 2009

Physical And Chemical Factors Controlling Carbon Gas Emissions And Organic Matter Transformation In Coastal Wetlands, Syam Kumar Dodla

LSU Doctoral Dissertations

Wetlands are important sinks for the atmospheric carbon (C) and play a major role in the global carbon cycle. However, factors impacting wetland soil C transformations and C gas production are not yet well understood. Elucidating these influences is especially important to Louisiana as wetlands are being impacted by salt water intrusion, subsidence and Mississippi river water diversion activities. This study evaluates, the effects of salinity, ions in river and sea water (K+, Ca2+) , clays and electron acceptors (NO3-, SO42-) on soil C transformations as well as C gas production from Louisiana coastal wetlands. Wetland soils were collected from …

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Effect Of Linker Structure On Surface Density Of Aptamer Monolayers And Their Corresponding Protein Binding Efficiency, Subramanian Balamurugan, Anne Obubuafo, Robin L. Mccarley, Steven A. Soper, David A. Spivak Dec 2008

Effect Of Linker Structure On Surface Density Of Aptamer Monolayers And Their Corresponding Protein Binding Efficiency, Subramanian Balamurugan, Anne Obubuafo, Robin L. Mccarley, Steven A. Soper, David A. Spivak

Faculty Publications

A systematic study is reported on the effect of linker size and its chemical composition toward ligand binding to a surface-immobilized aptamer, measured using surface plasmon resonance. The results, using thrombin as the model system, showed that as the number of thymidine (T) units in the linker increases from 0 to 20 in four separate increments (T0, T 5, T10, T20), the surface density of the aptamer decreased linearly from approximately 25 to 12 pmol·cm -2. The decrease in aptamer surface density occurred due to the increased size of the linker molecules. In addition, thrombin binding capacity was shown to …

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Uva-Induced Photo Recovery During Early Zebrafish Embryogenesis, Qiaoxiang Dong, W. Todd Monroe, Terrence R. Tiersch, Kurt R. Svoboda Dec 2008

Uva-Induced Photo Recovery During Early Zebrafish Embryogenesis, Qiaoxiang Dong, W. Todd Monroe, Terrence R. Tiersch, Kurt R. Svoboda

Faculty Publications

DNA photorepair has been widely studied in simple aquatic organisms that live in the marine environment, but is less understood in more complex species that live in freshwater. In the present study, we evaluated UVA-induced DNA photo recovery in embryonic stages of zebrafish, Danio rerio, a freshwater model species. Evaluation of UVB exposure and UVA photo recovery of zebrafish embryos revealed different UVB tolerances and capacities for UVA photo recovery at different stages of development. Effective UVA photo recovery was observed at 3 h post-fertilization (hpf), 6-7 hpf, and 12 hpf, but not in the early cleavage stage (2-32 cells). …

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Identification Of Adropin As A Secreted Factor Linking Dietary Macronutrient Intake With Energy Homeostasis And Lipid Metabolism, K. Ganesh Kumar, James L. Trevaskis, Daniel D. Lam, Gregory M. Sutton, Robert A. Koza, Vladimir N. Chouljenko, Konstantin G. Kousoulas, Pamela M. Rogers, Robert A. Kesterson, Marie Thearle, Anthony W. Ferrante, Randall L. Mynatt, Thomas P. Burris, Jesse Z. Dong, Heather A. Halem, Michael D. Culler, Lora K. Heisler, Jacqueline M. Stephens, Andrew A. Butler Dec 2008

Identification Of Adropin As A Secreted Factor Linking Dietary Macronutrient Intake With Energy Homeostasis And Lipid Metabolism, K. Ganesh Kumar, James L. Trevaskis, Daniel D. Lam, Gregory M. Sutton, Robert A. Koza, Vladimir N. Chouljenko, Konstantin G. Kousoulas, Pamela M. Rogers, Robert A. Kesterson, Marie Thearle, Anthony W. Ferrante, Randall L. Mynatt, Thomas P. Burris, Jesse Z. Dong, Heather A. Halem, Michael D. Culler, Lora K. Heisler, Jacqueline M. Stephens, Andrew A. Butler

Faculty Publications

Obesity and nutrient homeostasis are linked by mechanisms that are not fully elucidated. Here we describe a secreted protein, adropin, encoded by a gene, Energy Homeostasis Associated (Enho), expressed in liver and brain. Liver Enho expression is regulated by nutrition: lean C57BL/6J mice fed high-fat diet (HFD) exhibited a rapid increase, while fasting reduced expression compared to controls. However, liver Enho expression declines with diet-induced obesity (DIO) associated with 3 months of HFD or with genetically induced obesity, suggesting an association with metabolic disorders in the obese state. In DIO mice, transgenic overexpression or systemic adropin treatment attenuated hepatosteatosis and …

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Identification Of Adropin As A Secreted Factor Linking Dietary Macronutrient Intake With Energy Homeostasis And Lipid Metabolism, K. Ganesh Kumar, James L. Trevaskis, Daniel D. Lam, Gregory M. Sutton, Robert A. Koza, Vladimir N. Chouljenko, Konstantin G. Kousoulas, Pamela M. Rogers, Robert A. Kesterson, Marie Thearle, Anthony W. Ferrante, Randall L. Mynatt, Thomas P. Burris, Jesse Z. Dong, Heather A. Halem, Michael D. Culler, Lora K. Heisler, Jacqueline M. Stephens, Andrew A. Butler Dec 2008

Identification Of Adropin As A Secreted Factor Linking Dietary Macronutrient Intake With Energy Homeostasis And Lipid Metabolism, K. Ganesh Kumar, James L. Trevaskis, Daniel D. Lam, Gregory M. Sutton, Robert A. Koza, Vladimir N. Chouljenko, Konstantin G. Kousoulas, Pamela M. Rogers, Robert A. Kesterson, Marie Thearle, Anthony W. Ferrante, Randall L. Mynatt, Thomas P. Burris, Jesse Z. Dong, Heather A. Halem, Michael D. Culler, Lora K. Heisler, Jacqueline M. Stephens, Andrew A. Butler

Faculty Publications

Obesity and nutrient homeostasis are linked by mechanisms that are not fully elucidated. Here we describe a secreted protein, adropin, encoded by a gene, Energy Homeostasis Associated (Enho), expressed in liver and brain. Liver Enho expression is regulated by nutrition: lean C57BL/6J mice fed high-fat diet (HFD) exhibited a rapid increase, while fasting reduced expression compared to controls. However, liver Enho expression declines with diet-induced obesity (DIO) associated with 3 months of HFD or with genetically induced obesity, suggesting an association with metabolic disorders in the obese state. In DIO mice, transgenic overexpression or systemic adropin treatment attenuated hepatosteatosis and …

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Geographic, Seasonal, And Precipitation Chemistry Influence On The Abundance And Activity Of Biological Ice Nucleators In Rain And Snow, Brent C. Christner, Rongman Cai, Cindy E. Morris, Kevin S. Mccarter, Christine M. Foreman, Mark L. Skidmore, Scott N. Montross, David C. Sands Dec 2008

Geographic, Seasonal, And Precipitation Chemistry Influence On The Abundance And Activity Of Biological Ice Nucleators In Rain And Snow, Brent C. Christner, Rongman Cai, Cindy E. Morris, Kevin S. Mccarter, Christine M. Foreman, Mark L. Skidmore, Scott N. Montross, David C. Sands

Faculty Publications

Biological ice nucleators (IN) function as catalysts for freezing at relatively warm temperatures (warmer than -10°C). We examined the concentration (per volume of liquid) and nature of IN in precipitation collected from Montana and Louisiana, the Alps and Pyrenees (France), Ross Island (Antarctica), and Yukon (Canada). The temperature of detectable ice-nucleating activity for more than half of the samples was ≥ -5°C based on immersion freezing testing. Digestion of the samples with lysozyme (i.e., to hydrolyze bacterial cell walls) led to reductions in the frequency of freezing (0-100%); heat treatment greatly reduced (95% average) or completely eliminated ice nucleation at …

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Development Of Theta Rhythmicity In Entorhinal Stellate Cells Of The Juvenile Rat., Burton Bg, Economo Mn, Lee Gj, White Ja Dec 2008

Development Of Theta Rhythmicity In Entorhinal Stellate Cells Of The Juvenile Rat., Burton Bg, Economo Mn, Lee Gj, White Ja

Faculty Publications

No abstract provided.

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Escherichia Coli Ftna Acts As An Iron Buffer For Re-Assembly Of Iron-Sulfur Clusters In Response To Hydrogen Peroxide Stress, Jacob P. Bitoun, Genfu Wu, Huangen Ding Dec 2008

Escherichia Coli Ftna Acts As An Iron Buffer For Re-Assembly Of Iron-Sulfur Clusters In Response To Hydrogen Peroxide Stress, Jacob P. Bitoun, Genfu Wu, Huangen Ding

Faculty Publications

Iron-sulfur clusters are one of the most ubiquitous redox centers in biology. Ironically, iron-sulfur clusters are highly sensitive to reactive oxygen species. Disruption of iron-sulfur clusters will not only change the activity of proteins that host iron-sulfur clusters, the iron released from the disrupted iron-sulfur clusters will further promote the production of deleterious hydroxyl free radicals via the Fenton reaction. Here, we report that ferritin A (FtnA), a major iron-storage protein in Escherichia coli, is able to scavenge the iron released from the disrupted iron-sulfur clusters and alleviates the production of hydroxyl free radicals. Furthermore, we find that the iron …

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