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Chemical Communication In Insects: New Advances In Integrated Pest Management Strategies, Angel Guerrero, Gadi V.P. Reddy Oct 2023

Chemical Communication In Insects: New Advances In Integrated Pest Management Strategies, Angel Guerrero, Gadi V.P. Reddy

Faculty Publications

No abstract provided.

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Nod Mice Have Distinct Metabolic And Immunologic Profiles When Compared With Genetically Similar Mhc-Matched Icr Mice, Heidi M. Batdorf, Luz De Luna Lawes, Jeremy T. Richardson, David H. Burk, Samuel D. Dupuy, Michael D. Karlstad, Robert C. Noland, Susan J. Burke, J. Jason Collier Oct 2023

Nod Mice Have Distinct Metabolic And Immunologic Profiles When Compared With Genetically Similar Mhc-Matched Icr Mice, Heidi M. Batdorf, Luz De Luna Lawes, Jeremy T. Richardson, David H. Burk, Samuel D. Dupuy, Michael D. Karlstad, Robert C. Noland, Susan J. Burke, J. Jason Collier

Division of Basic Science Faculty Publications

Nonobese diabetic (NOD) mice are the most commonly used rodent model to study mechanisms relevant to the autoimmunity and immunology of type 1 diabetes. Although many different strains of mice have been used as controls for studies comparing nondiabetic lines to the NOD strain, we hypothesized that the parental strain that gave rise to the NOD line might be one of the best options. Therefore, we compared female ICR and NOD mice, which are matched at key major histocompatibility complex (MHC) loci, to understand their metabolic and immunologic similarities and differences. Several novel observations emerged: 1) NOD mice have greater …

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Genetic Deletion Of Dnajb3 Using Crispr-Cas9, Produced Discordant Phenotypes, Shadi Nejat, Kalhara R. Menikdiwela, Aliyah Efotte, Shane Scoggin, Bolormaa Vandanmagsar, Paul J. Thornalley, Mohammed Dehbi, Naima Moustaid-Moussa Oct 2023

Genetic Deletion Of Dnajb3 Using Crispr-Cas9, Produced Discordant Phenotypes, Shadi Nejat, Kalhara R. Menikdiwela, Aliyah Efotte, Shane Scoggin, Bolormaa Vandanmagsar, Paul J. Thornalley, Mohammed Dehbi, Naima Moustaid-Moussa

Division of Basic Science Faculty Publications

Several pathways and/or genes have been shown to be dysregulated in obesity-induced insulin resistance (IR) and type 2 diabetes (T2D). We previously showed, for the first time, impaired expression of DNAJB3 mRNA and protein in subjects with obesity, which was concomitant with increased metabolic stress. Restoring the normal expression of DNAJB3 attenuated metabolic stress and improved insulin signaling both in vivo and in vitro, suggesting a protective role of DNAJB3 against obesity and T2D. The precise underlying mechanisms remained, however, unclear. This study was designed to confirm the human studies in a mouse model of dietary obesity-induced insulin resistance, and, …

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Soluble Rage And Skeletal Muscle Tissue Rage Expression Profiles In Lean And Obese Young Adults Across Differential Aerobic Exercise Intensities, Edwin R. Miranda, Jacob T. Mey, Brian K. Blackburn, Alec B. Chaves, Kelly N.Z. Fuller, Ryan K. Perkins, Andrew T. Ludlow, Jacob M. Haus Oct 2023

Soluble Rage And Skeletal Muscle Tissue Rage Expression Profiles In Lean And Obese Young Adults Across Differential Aerobic Exercise Intensities, Edwin R. Miranda, Jacob T. Mey, Brian K. Blackburn, Alec B. Chaves, Kelly N.Z. Fuller, Ryan K. Perkins, Andrew T. Ludlow, Jacob M. Haus

Division of Basic Science Faculty Publications

Nearly 40% of Americans have obesity and are at increased risk for developing type 2 diabetes. Skeletal muscle is responsible for >80% of insulin-stimulated glucose uptake that is attenuated by the inflammatory milieu of obesity and augmented by aerobic exercise. The receptor for advanced glycation endproducts (RAGE) is an inflammatory receptor directly linking metabolic dysfunction with inflammation. Circulating soluble isoforms of RAGE (sRAGE) formed either by proteolytic cleavage (cRAGE) or alternative splicing (esRAGE) act as decoys for RAGE ligands, thereby counteracting RAGE-mediated inflammation. We aimed to determine if RAGE expression or alternative splicing of RAGE is altered by obesity in …

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Environmentally Persistent Free Radicals: Methods For Combustion Generation, Whole-Body Inhalation And Assessing Cardiopulmonary Consequences, Ankit Aryal, Alexandra Noël, Lavrent Khachatryan, Stephania A. Cormier, Pratiti H. Chowdhury, Arthur Penn, Tammy R. Dugas, Ashlyn C. Harmon Oct 2023

Environmentally Persistent Free Radicals: Methods For Combustion Generation, Whole-Body Inhalation And Assessing Cardiopulmonary Consequences, Ankit Aryal, Alexandra Noël, Lavrent Khachatryan, Stephania A. Cormier, Pratiti H. Chowdhury, Arthur Penn, Tammy R. Dugas, Ashlyn C. Harmon

Division of Basic Science Faculty Publications

Particulate matter (PM) containing environmentally persistent free radicals (EPFRs) results from the incomplete combustion of organic wastes which chemisorb to transition metals. This process generates a particle-pollutant complex that continuously redox cycles to produce reactive oxygen species. EPFRs are well characterized, but their cardiopulmonary effects remain unknown. This publication provides a detailed approach to evaluating these effects and demonstrates the impact that EPFRs have on the lungs and vasculature. Combustion-derived EPFRs were generated (EPFR lo: 2.1e−16 radical/g, EPFR hi: 5.5e−17 radical/g), characterized, and verified as representative of those found in urban areas. Dry particle aerosolization and whole-body inhalation were established …

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Impact Of A Nutrient Formulation On Longitudinal Myelination, Cognition, And Behavior From Birth To 2 Years: A Randomized Clinical Trial, Nora Schneider, Mickaël Hartweg, Jonathan O’Regan, Jennifer Beauchemin, Leanne Redman, Daniel S. Hsia, Pascal Steiner, Owen Carmichael, Viren D’Sa, Sean Deoni Oct 2023

Impact Of A Nutrient Formulation On Longitudinal Myelination, Cognition, And Behavior From Birth To 2 Years: A Randomized Clinical Trial, Nora Schneider, Mickaël Hartweg, Jonathan O’Regan, Jennifer Beauchemin, Leanne Redman, Daniel S. Hsia, Pascal Steiner, Owen Carmichael, Viren D’Sa, Sean Deoni

Clinical Research Faculty Publications

Observation studies suggest differences in myelination in relation to differences in early life nutrition. This two-center randomized controlled trial investigates the effect of a 12-month nutritional intervention on longitudinal changes in myelination, cognition, and behavior. Eighty-one full-term, neurotypical infants were randomized into an investigational (N = 42) or a control group (N = 39), receiving higher versus lower levels of a blend of nutrients. Non-randomized breastfed infants (N = 108) served as a reference group. Main outcomes were myelination (MRI), neurodevelopment (Bayley-III), social-emotional development (ASQ:SE-2), infant and toddler behavior (IBQ-R and TBAQ), and infant sleep (BISQ) during the first 2 …

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Sexually Dimorphic Oxytocin Receptor-Expressing (Oxtr) Neurons In The Anteroventral Periventricular Nucleus (Avpv) In The Postpartum Female Mouse Are Involved In Maternal Behavior, Kaustubh Sharma, Armita A. Govar, Bandana Ghimire, Katsuhiko Nishimori, Elizabeth Hammock, Ryoichi Teruyama Oct 2023

Sexually Dimorphic Oxytocin Receptor-Expressing (Oxtr) Neurons In The Anteroventral Periventricular Nucleus (Avpv) In The Postpartum Female Mouse Are Involved In Maternal Behavior, Kaustubh Sharma, Armita A. Govar, Bandana Ghimire, Katsuhiko Nishimori, Elizabeth Hammock, Ryoichi Teruyama

Faculty Publications

Maternal care is crucial for the survival and development of offspring. Oxytocin modulates maternal behavior by binding to oxytocin receptors (OXTRs) in various parts of the brain. Previously, we showed that OXTRs are expressed in the anteroventral periventricular nucleus (AVPV) of female, but not male mice. Because the AVPV is involved in the regulation of maternal behavior and oxytocin enhances its induction, this finding leads to the hypothesis that the female specific population of OXTR neurons in the AVPV regulates maternal behavior. To address this hypothesis, OXTR-Venus reporter mice were used to assess if expression levels of OXTR in the …

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Association Of Prolactin With All-Cause And Cardiovascular Mortality Among Patients With Type 2 Diabetes: A Real-World Study, Yun Shen, Qing Yang, Tingting Hu, Yaxin Wang, Lei Chen, Fei Gao, Wei Zhu, Gang Hu, Jian Zhou, Chunfang Wang, Yuqian Bao Oct 2023

Association Of Prolactin With All-Cause And Cardiovascular Mortality Among Patients With Type 2 Diabetes: A Real-World Study, Yun Shen, Qing Yang, Tingting Hu, Yaxin Wang, Lei Chen, Fei Gao, Wei Zhu, Gang Hu, Jian Zhou, Chunfang Wang, Yuqian Bao

Population and Public Health Science Faculty Publications

Aims The association between prolactin and mortality has been less studied, and findings were inconsistent among different populations. We aimed to investigate the association between serum prolactin (PRL) and mortality among patients with type 2 diabetes. Methods We performed a retrospective cohort study of 10 907 patients with at least 2 prolactin measurements within 2 years since and results their first inpatient diagnosis of type 2 diabetes. Baseline and mean values of serum PRL were used as exposures. A multivariable-adjusted Cox proportional hazards model was used to estimate the association between PRL and mortality. During a mean follow-up of 5.34 …

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Greater Male Variability In Daily Energy Expenditure Develops Through Puberty, Lewis G. Halsey, Vincent Careau, Philip N. Ainslie, Heliodoro Alemán-Mateo, Lene F. Andersen, Liam J. Anderson, Leonore Arab, Issad Baddou, Linda Bandini, Kweku Bedu-Addo, Ellen E. Blaak, Stephane Blanc, Alberto G. Bonomi, Carlijn V.C. Bouten, Pascal Bovet, Soren Brage, Maciej S. Buchowski, Nancy Butte, Stephan G. Camps, Regian Casper, Graeme L. Close, Lisa H. Colbert, Jamie A. Cooper, Richard Cooper, Prasangi Dabare, Sai Krupa Das, Peter S.W. Davies, Sanjoy Deb, Christine Delisle Nyström, William Dietz, Lara R. Dugas, Simon Eaton, Ulf Ekelund Sep 2023

Greater Male Variability In Daily Energy Expenditure Develops Through Puberty, Lewis G. Halsey, Vincent Careau, Philip N. Ainslie, Heliodoro Alemán-Mateo, Lene F. Andersen, Liam J. Anderson, Leonore Arab, Issad Baddou, Linda Bandini, Kweku Bedu-Addo, Ellen E. Blaak, Stephane Blanc, Alberto G. Bonomi, Carlijn V.C. Bouten, Pascal Bovet, Soren Brage, Maciej S. Buchowski, Nancy Butte, Stephan G. Camps, Regian Casper, Graeme L. Close, Lisa H. Colbert, Jamie A. Cooper, Richard Cooper, Prasangi Dabare, Sai Krupa Das, Peter S.W. Davies, Sanjoy Deb, Christine Delisle Nyström, William Dietz, Lara R. Dugas, Simon Eaton, Ulf Ekelund

Faculty Publications

There is considerably greater variation in metabolic rates between men than between women, in terms of basal, activity and total (daily) energy expenditure (EE). One possible explanation is that EE is associated with male sexual characteristics (which are known to vary more than other traits) such as musculature and athletic capacity. Such traits might be predicted to be most prominent during periods of adolescence and young adulthood, when sexual behaviour develops and peaks. We tested this hypothesis on a large dataset by comparing the amount of male variation and female variation in total EE, activity EE and basal EE, at …

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Lipid Correction For Carbon Stable Isotope Analysis Of Yellowfin Tuna, Michael A. Dance, Mitchell S. Lovell Sep 2023

Lipid Correction For Carbon Stable Isotope Analysis Of Yellowfin Tuna, Michael A. Dance, Mitchell S. Lovell

Faculty Publications

Carbon stable isotopes (δ13C) are widely used in ecological studies to understand diet, food web dynamics, and movements of marine fishes. Still, δ13C is influenced by lipid content and often requires chemical extraction or mathematical correction. Here, we developed a species-specific mathematical lipid correction for white muscle tissue of yellowfin tuna (Thunnus albacares), a highly migratory finfish of considerable economic and ecological value. Lipid extraction was conducted on yellowfin tuna white muscle tissue (C:N range: 2.96–6.49), and both linear and non-linear lipid correction models for δ13C were fitted and assessed. Lipid extraction increased δ …

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Serum Sulfur-Containing Amino Acids And Risk Of Maternal Gestational Diabetes And Adverse Growth Patterns In Offspring, Ninghua Li, Jing Li, Hui Wang, Yijuan Qiao, Weiqin Li, Ming Gao, Enqing Liu, Zhijie Yu, Gang Hu, Zhongze Fang, Junhong Leng, Xilin Yang Sep 2023

Serum Sulfur-Containing Amino Acids And Risk Of Maternal Gestational Diabetes And Adverse Growth Patterns In Offspring, Ninghua Li, Jing Li, Hui Wang, Yijuan Qiao, Weiqin Li, Ming Gao, Enqing Liu, Zhijie Yu, Gang Hu, Zhongze Fang, Junhong Leng, Xilin Yang

Population and Public Health Science Faculty Publications

Background: To estimate associations of sulfur-containing amino acids (SAAs) in the early trimester of pregnancy and gestational diabetes mellitus (GDM) and estimate associations of maternal SAAs with adverse growth patterns in offspring. Methods: We established a 1:1 matched case-control study (n = 486) from our cohort of pregnant women, and 401 children were followed up at ages 1 to 8 years. We conducted binary conditional logistic regression to estimate the risk associations of serum SAAs with GDM. Multinomial logistic regression was implemented to explore associations of maternal SAAs with adverse growth patterns in the offspring. Results: High serum methionine and …

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The Problem With Repurposing Genetically Modified Organisms, Robert Kesterson, Elizabeth Floyd Sep 2023

The Problem With Repurposing Genetically Modified Organisms, Robert Kesterson, Elizabeth Floyd

Division of Basic Science Faculty Publications

No abstract provided.

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Extract Of Artemisia Dracunculus L. Modulates Osteoblast Proliferation And Mineralization, Matthew C. Scott, Aleah Bourgeois, Yongmei Yu, David H. Burk, Brenda J. Smith, Z. Elizabeth Floyd Sep 2023

Extract Of Artemisia Dracunculus L. Modulates Osteoblast Proliferation And Mineralization, Matthew C. Scott, Aleah Bourgeois, Yongmei Yu, David H. Burk, Brenda J. Smith, Z. Elizabeth Floyd

Division of Basic Science Faculty Publications

Thiazolidinediones (TZD) significantly improve insulin sensitivity via action on adipocytes. Unfortunately, TZDs also degrade bone by inhibiting osteoblasts. An extract of Artemisia dracunculus L., termed PMI5011, improves blood glucose and insulin sensitivity via skeletal muscle, rather than fat, and may therefore spare bone. Here, we examine the effects of PMI5011 and an identified active compound within PMI5011 (2′,4′-dihydroxy-4-methoxydihydrochalcone, DMC-2) on pre-osteoblasts. We hypothesized that PMI5011 and DMC-2 will not inhibit osteogenesis. To test our hypothesis, MC3T3-E1 cells were induced in osteogenic media with and without PMI5011 or DMC-2. Cell lysates were probed for osteogenic gene expression and protein content and …

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Reduced Postabsorptive Interoception Of Nutrients In Obesity: Cause Or Consequence?, Hans Rudolf Berthoud Sep 2023

Reduced Postabsorptive Interoception Of Nutrients In Obesity: Cause Or Consequence?, Hans Rudolf Berthoud

Division of Basic Science Faculty Publications

No abstract provided.

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Sarcopenic Obesity: Emerging Mechanisms And Therapeutic Potential, Christopher L. Axelrod, Wagner S. Dantas, John P. Kirwan Sep 2023

Sarcopenic Obesity: Emerging Mechanisms And Therapeutic Potential, Christopher L. Axelrod, Wagner S. Dantas, John P. Kirwan

Division of Basic Science Faculty Publications

Sarcopenic obesity, or the loss of muscle mass and function associated with excess adiposity, is a largely untreatable medical condition associated with diminished quality of life and increased risk of mortality. To date, it remains somewhat paradoxical and mechanistically undefined as to why a subset of adults with obesity develop muscular decline, an anabolic stimulus generally associated with retention of lean mass. Here, we review evidence surrounding the definition, etiology, and treatment of sarcopenic obesity with an emphasis on emerging regulatory nodes with therapeutic potential. We review the available clinical evidence largely focused on diet, lifestyle, and behavioral interventions to …

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Persistent Hypoxia With Intermittent Aggravation Causes Imbalance In Smad3/Myocardin-Related Transcription Factor Signaling With Consequent Endothelial Senescence And Pulmonary Arterial Remodeling, Jiaxin Hu, Prachi Singh, Jingrui Li, Jing Zhang, Fei Li, Hehe Zhang, Jiang Xie Sep 2023

Persistent Hypoxia With Intermittent Aggravation Causes Imbalance In Smad3/Myocardin-Related Transcription Factor Signaling With Consequent Endothelial Senescence And Pulmonary Arterial Remodeling, Jiaxin Hu, Prachi Singh, Jingrui Li, Jing Zhang, Fei Li, Hehe Zhang, Jiang Xie

Clinical Research Faculty Publications

Loss of Smad3 and the consequent activation of myocardin-related transcription factor (MRTF) are associated with vascular pathologies. This study aimed to examine the impact of persistent hypoxia with intermittent aggravation (PI hypoxia) on cellular senescence and pulmonary arterial remodeling mediated by the Smad3/MRTF imbalance. We examined the effects of PI hypoxia on the Smad3/MRTF pathway and cellular senescence using human pulmonary artery endothelial cells (HPAECs) and in vivo studies in rats. The senescent degree was evaluated using β-galactosidase staining, p16 quantitation and the measurement of senescence-associated secretory phenotype. Structural data in the pathological analysis of pulmonary artery remodeling were collected. …

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Global Rural Health Disparities In Alzheimer's Disease And Related Dementias: State Of The Science, Lisa Ann Kirk Wiese, Allison Gibson, Marc Aaron Guest, Amy R. Nelson, Raven Weaver, Aditi Gupta, Owen Carmichael, Jordan P. Lewis, Allison Lindauer, Samantha Loi, Rachel Peterson, Kylie Radford, Elizabeth K. Rhodus, Christina G. Wong, Megan Zuelsdorff, Ladan Ghazi Saidi, Esmeralda Valdivieso-Mora, Sanne Franzen, Caitlin N. Pope, Timothy S. Killian, Hom L. Shrestha, Patricia C. Heyn, Ted Kheng Siang Ng, Beth Prusaczyk, Samantha John, Ambar Kulshreshtha, Julia L. Sheffler, Lilah Besser, Valerie Daniel, Magdalena I. Tolea, Justin Miller, Christine Musyimi, Jon Corkey, Veronica Yank Sep 2023

Global Rural Health Disparities In Alzheimer's Disease And Related Dementias: State Of The Science, Lisa Ann Kirk Wiese, Allison Gibson, Marc Aaron Guest, Amy R. Nelson, Raven Weaver, Aditi Gupta, Owen Carmichael, Jordan P. Lewis, Allison Lindauer, Samantha Loi, Rachel Peterson, Kylie Radford, Elizabeth K. Rhodus, Christina G. Wong, Megan Zuelsdorff, Ladan Ghazi Saidi, Esmeralda Valdivieso-Mora, Sanne Franzen, Caitlin N. Pope, Timothy S. Killian, Hom L. Shrestha, Patricia C. Heyn, Ted Kheng Siang Ng, Beth Prusaczyk, Samantha John, Ambar Kulshreshtha, Julia L. Sheffler, Lilah Besser, Valerie Daniel, Magdalena I. Tolea, Justin Miller, Christine Musyimi, Jon Corkey, Veronica Yank

Clinical Research Faculty Publications

INTRODUCTION: Individuals living in rural communities are at heightened risk for Alzheimer's disease and related dementias (ADRD), which parallels other persistent place-based health disparities. Identifying multiple potentially modifiable risk factors specific to rural areas that contribute to ADRD is an essential first step in understanding the complex interplay between various barriers and facilitators. METHODS: An interdisciplinary, international group of ADRD researchers convened to address the overarching question of: “What can be done to begin minimizing the rural health disparities that contribute uniquely to ADRD?” In this state of the science appraisal, we explore what is known about the biological, behavioral, …

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Effects Of Weevil (Rhynchophorus Palmarum), Teosinte (Dioon Mejiae) And Caesar’S Mushroom (Amanita Caesarea) On The Properties Of Lactobacillus Acidophilus La-K, Ricardo S. Aleman, Dany Avila, Allan Avila, Jhunior Marcia, David Picha, Kayanush Aryana, Ismael Montero-Fernández Sep 2023

Effects Of Weevil (Rhynchophorus Palmarum), Teosinte (Dioon Mejiae) And Caesar’S Mushroom (Amanita Caesarea) On The Properties Of Lactobacillus Acidophilus La-K, Ricardo S. Aleman, Dany Avila, Allan Avila, Jhunior Marcia, David Picha, Kayanush Aryana, Ismael Montero-Fernández

Faculty Publications

Weevil (Rhynchophorus palmarum) powder, teosinte (Dioon mejiae) and Caesar’s mushroom (Amanita caesarea) flour have bioactive compounds with significant nutritional applications. This paper aimed to examine the influence of weevil, teosinte, and mushroom powders on the protease activity, acid tolerance, bile tolerance, lysozyme tolerance, and gastric juice resistance ability of Lactobacillus acidophilus LA-K. Acid tolerance was determined by adjusting the pH of MRS broth to 2.0 for L. acidophilus incubated under aerobic conditions at 37 °C. Bile tolerance was determined by incorporating 0.3% of oxgall. Protease activity was determined spectrophotometrically at 340 nm. Resistance to 100 mg/L of lysozyme in an …

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A Sensitive Strain Sensor Based On Multi-Walled Carbon Nanotubes/Polyaniline/Silicone Rubber Nanocomposite For Human Motion Detection, Seyedmajid Hosseini, Mohsen Norouzi, Jian Xu Sep 2023

A Sensitive Strain Sensor Based On Multi-Walled Carbon Nanotubes/Polyaniline/Silicone Rubber Nanocomposite For Human Motion Detection, Seyedmajid Hosseini, Mohsen Norouzi, Jian Xu

Faculty Publications

Strain sensors play a pivotal role in quantifying stress and strain across diverse domains, encompassing engineering, industry, and medicine. Their applicability has recently extended into the realm of wearable electronics, enabling real-time monitoring of body movements. However, conventional strain sensors, while extensively employed, grapple with limitations such as diminished sensitivity, suboptimal tensile strength, and susceptibility to environmental factors. In contrast, polymer-based composite strain sensors have gained prominence for their capability to surmount these challenges. The integration of carbon nanotubes (CNTs) as reinforcing agents within the polymer matrix ushers in a transformative era, bolstering mechanical strength, electrical conductivity, and thermal stability. …

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Evaluation Of Organic And Synthetic Herbicides Applications On Indicators Of Soil Health And Weed Suppression In A Conventional Cropping System In Louisiana, Caitlin Denux Aug 2023

Evaluation Of Organic And Synthetic Herbicides Applications On Indicators Of Soil Health And Weed Suppression In A Conventional Cropping System In Louisiana, Caitlin Denux

LSU Doctoral Dissertations

Synthetic herbicides, with their varying modes of action, are well known for their efficiency in the suppression and control of weed species in U.S. agriculture. However, the consequences of using synthetic herbicides without attention to the surrounding environment can produce chemical run-off, changes in soil health and soil health conditions, and create herbicide-resistant weeds. These consequences have encouraged growers to find alternatives in their weed management programs. In this study, organic and synthetic herbicides were assessed on how well they performed in weed suppression surveys, and their potential effects on soil health indicators. Commonly used indicators include soil pH, β-glucosidase …

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A Multi-Aerial Vehicle Platform For Testing Collaborative Mobility Formation Controllers, Matthew Snellgrove Aug 2023

A Multi-Aerial Vehicle Platform For Testing Collaborative Mobility Formation Controllers, Matthew Snellgrove

LSU Master's Theses

Multi-agent systems have potential applications in a multitude of fields due to their ability to perform complex tasks with a high degree of robustness. Decentralized systems are multi-agent systems where sensing, control, and communication responsibilities are distributed amongst the agents giving this scheme a particularly high potential for robustness, adaptability, and complexity; however, this comes with its own list of challenges. Formation control is a topic in multi-agent systems that aims to have the agents moving as a virtual rigid body through space. In the literature, there have been successful implementation of formation control algorithms on robot agents in both …

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An Essay On Cover Crops, Crop Yield Risks And Crop Insurance, Rajan Dhakal Aug 2023

An Essay On Cover Crops, Crop Yield Risks And Crop Insurance, Rajan Dhakal

LSU Doctoral Dissertations

To reduce the rising negative environmental impacts of crop production (e.g., chemical runoff, soil erosion) using conservation practices in farming has become a very important policy and research focus. However, the interest of farmers in adopting conservation practices is highly dependent on the potential private benefits that these practices create. With the chances for increased weather variability and frequent extreme weather conditions, cover crops have been gaining more attention, as their on-farm benefits can provide an effective buffer against unfavorable weather events such as excess dry and wet conditions. Despite providing several benefits, cover crop adoption in the US remain …

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Modeling Of Heat And Mass Transfer In Flat Heat Pipes, Salar Saadatian Aug 2023

Modeling Of Heat And Mass Transfer In Flat Heat Pipes, Salar Saadatian

LSU Doctoral Dissertations

Phase-change phenomenon is ubiquitous in nature and widely utilized in thermal management of computer chips. Flat heat pipes have been extensively used in thermal management of microelectronic devices. However, existing research mainly concentrates on developing numerical models and lacks a systematic analytical approach to elucidate the working mechanism of flat heat pipes. We consider a horizontal flat heat pipe with an idealized porous wick. The pores in the wick are straight circular capillaries running along and across the wick and are filled with a liquid. The rest of the pipe is filled with its vapor. The mass evaporative rate at …

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The Pathophysiology Of Equine Glandular Gastric Disease: Investigating The Role Of The Mucosal Microbiome And Bile Acid Reflux, Linda Paul Aug 2023

The Pathophysiology Of Equine Glandular Gastric Disease: Investigating The Role Of The Mucosal Microbiome And Bile Acid Reflux, Linda Paul

LSU Doctoral Dissertations

Equine glandular gastric disease (EGGD) is a common disease of athletic horses that can affect performance and welfare. Clinical signs are non-specific and diagnosis is made using gastroscopy after a prolonged fasting period. Effective prevention and treatment strategies for EGGD are lacking despite its widespread prevalence and negative effects. The goal of this research was to investigate the pathophysiology of EGGD. Objectives included: 1) compare the gastric glandular mucosal microbiome in horses with and without EGGD, 2) assess the influence of dietary and management factors on the gastric microbiome, and 3) evaluate the pyloric gastric fluid bile acid profile in …

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Reduction Of Sparc Protects Mice Against Nlrp3 Inflammasome Activation And Obesity, Seungjin Ryu, Olga Spadaro, Sviatoslav Sidorov, Aileen H. Lee, Sonia Caprio, Christopher Morrison, Steven R. Smith, Eric Ravussin, Irina Shchukina, Maxim N. Artyomov, Yun Hee Youm, Vishwa Deep Dixit Aug 2023

Reduction Of Sparc Protects Mice Against Nlrp3 Inflammasome Activation And Obesity, Seungjin Ryu, Olga Spadaro, Sviatoslav Sidorov, Aileen H. Lee, Sonia Caprio, Christopher Morrison, Steven R. Smith, Eric Ravussin, Irina Shchukina, Maxim N. Artyomov, Yun Hee Youm, Vishwa Deep Dixit

Division of Basic Science Faculty Publications

The comprehensive assessment of long-term effects of reducing intake of energy (CALERIE-II; NCT00427193) clinical trial established that caloric restriction (CR) in humans lowers inflammation. The identity and mechanism of endogenous CR-mimetics that can be deployed to control obesity-associated inflammation and diseases are not well understood. Our studies have found that 2 years of 14% sustained CR in humans inhibits the expression of the matricellular protein, secreted protein acidic and rich in cysteine (SPARC), in adipose tissue. In mice, adipose tissue remodeling caused by weight loss through CR and low-protein diet feeding decreased, while high-fat diet–induced (HFD-induced) obesity increased SPARC expression …

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Narrative Infidelity And White Resentment In The Rhetorical Mobilization Of The Anti-Crt Movement, Julien Burns Aug 2023

Narrative Infidelity And White Resentment In The Rhetorical Mobilization Of The Anti-Crt Movement, Julien Burns

LSU Master's Theses

Beginning in the summer of 2020, an activist movement has arisen in opposition to Critical Race Theory (CRT). This movement has mobilized tens of thousands of Americans and passed policy curtailing the discussion of race in classrooms despite a lack of evidence that CRT has any meaningful presence in many of the public institutions targeted. This movement challenges logic-based conceptions of rhetorical persuasion and demands an alternative model. In this thesis, I propose that a narrative conception of rhetoric provides a framework for understanding how this movement is rational, despite the falsifiability of its foundation. Specifically, I respond to Walter …

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Can Gulf Ribbed Mussels Enhance Coastal Restoration Projects In A Future With Climate Change?, Skylar Liner Aug 2023

Can Gulf Ribbed Mussels Enhance Coastal Restoration Projects In A Future With Climate Change?, Skylar Liner

LSU Master's Theses

Living shorelines present one restoration approach using biotic elements (via ecosystem engineers) to stabilize shorelines and increase valuable habitat. Gulf ribbed mussels (Geukensia granosissima) are important ecosystem engineers within brackish and salt marshes in the northern Gulf of Mexico, and can increase nutrient availability, enhance marsh vegetation production, and potentially improve shoreline stability. It is unknown whether mussels will maintain these functions as future climate change predicts increases in temperature and water level, which may exceed the mussel’s tolerance. A field survey conducted during the summer of 2022 identified the daily maximum temperature at the marsh surface, where mussels naturally …

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Trophic Amplification: A Model Intercomparison Of Climate Driven Changes In Marine Food Webs, Vianney Guibourd De Luzinais, Hubert Du Pontavice, Gabriel Reygondeau, Nicolas Barrier, Julia L. Blanchard, Virginie Bornarel, Matthias Büchner, William W.L. Cheung, Tyler D. Eddy, Jason D. Everett, Jerome Guiet, Cheryl S. Harrison, Olivier Maury, Camilla Novaglio, Colleen M. Petrik, Jeroen Steenbeek, Derek P. Tittensor, Didier Gascuel Aug 2023

Trophic Amplification: A Model Intercomparison Of Climate Driven Changes In Marine Food Webs, Vianney Guibourd De Luzinais, Hubert Du Pontavice, Gabriel Reygondeau, Nicolas Barrier, Julia L. Blanchard, Virginie Bornarel, Matthias Büchner, William W.L. Cheung, Tyler D. Eddy, Jason D. Everett, Jerome Guiet, Cheryl S. Harrison, Olivier Maury, Camilla Novaglio, Colleen M. Petrik, Jeroen Steenbeek, Derek P. Tittensor, Didier Gascuel

Faculty Publications

Marine animal biomass is expected to decrease in the 21st century due to climate driven changes in ocean environmental conditions. Previous studies suggest that the magnitude of the decline in primary production on apex predators could be amplified through the trophodynamics of marine food webs, leading to larger decreases in the biomass of predators relative to the decrease in primary production, a mechanism called trophic amplification. We compared relative changes in producer and consumer biomass or production in the global ocean to assess the extent of trophic amplification. We used simulations from nine marine ecosystem models (MEMs) from the Fisheries …

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Longitudinal Assessment Of Cognitive Function In The Appswe/Ps1de9 Mouse Model Of Alzheimer's-Related Beta-Amyloidosis, Paul L. Soto, Michael E. Young, Giuliana M. Dimarco, Brianna George, Tatiana Melnikova, Alena V. Savonenko, Breanna N. Harris Aug 2023

Longitudinal Assessment Of Cognitive Function In The Appswe/Ps1de9 Mouse Model Of Alzheimer's-Related Beta-Amyloidosis, Paul L. Soto, Michael E. Young, Giuliana M. Dimarco, Brianna George, Tatiana Melnikova, Alena V. Savonenko, Breanna N. Harris

Faculty Publications

Preclinical models of Alzheimer's disease (AD)-related cognitive decline can be useful for developing therapeutics. The current study longitudinally assessed short-term memory, using a delayed matching-to-position (DMTP) task, and attention, using a 3-choice serial reaction time (3CSRT) task, from approximately 18 weeks of age through death or 72 weeks of age in APPswe/PS1dE9 mice, a widely used mouse model of AD-related amyloidosis. Both transgenic (Tg) and non-Tg mice exhibited improvements in DMTP accuracy over time. Breaks in testing reduced DMTP accuracy but accuracy values quickly recovered in both Tg and non-Tg mice. Both Tg and non-Tg mice exhibited high accuracy in …

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The Vagus Nerve Mediates Gut-Brain Response To Duodenal Nutrient Administration, Robert C. Ross, Yanlin He, R. Leigh Townsend, Philip R. Schauer, Hans Rudolph Berthoud, Christopher D. Morrison, Vance L. Albaugh Aug 2023

The Vagus Nerve Mediates Gut-Brain Response To Duodenal Nutrient Administration, Robert C. Ross, Yanlin He, R. Leigh Townsend, Philip R. Schauer, Hans Rudolph Berthoud, Christopher D. Morrison, Vance L. Albaugh

Division of Basic Science Faculty Publications

Background: Obesity contributes significant disease burden worldwide, including diabetes, cardiovascular disease, and cancer. While bariatric surgery is the most effective and durable obesity treatment, the mechanisms underlying its effects remain unknown. Although neuro-hormonal mechanisms have been suspected to mediate at least some of the gut-brain axis changes following bariatric surgery, studies examining the intestine and its regionally specific post-gastric alterations to these signals remain unclear. Materials and methods: Vagus nerve recording was performed following the implantation of duodenal feeding tubes in mice. Testing conditions and measurements were made under anesthesia during baseline, nutrient or vehicle solution delivery, and post-delivery. Solutions …

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