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Functional Morphology Of The Connective Tissue Of The Clavicular System Of The Domestic Cat, Felis Catus, Amanda N. Cooper Dec 2014

Functional Morphology Of The Connective Tissue Of The Clavicular System Of The Domestic Cat, Felis Catus, Amanda N. Cooper

Honors Capstones

No abstract provided.


An Exploration Of Cell Cycle Regulation In Arabidopsis Thaliana Trichomes, Ashley Willis Dec 2014

An Exploration Of Cell Cycle Regulation In Arabidopsis Thaliana Trichomes, Ashley Willis

Honors Capstones

No abstract provided.


Functional Morphology Of The Connective Tissue Of The Clavicular System Of The Domestic Cat, Felis Catus, Amanda N. Cooper Dec 2014

Functional Morphology Of The Connective Tissue Of The Clavicular System Of The Domestic Cat, Felis Catus, Amanda N. Cooper

Honors Capstones

No abstract provided.


The Drivers Of Tropical Speciation, Brian Tilston Smith, John E. Mccormack, Andrés M. Cuervo, Michael J. Hickerson, Alexandre Aleixo, Carlos Daniel Cadena, Jorge Pérez-Emán, Curtis W. Burney, Xiaoou Xie, Michael G. Harvey, Brant C. Faircloth, Travis C. Glenn, Elizabeth P. Derryberry, Jesse Prejean, Samantha Fields, Robb T. Brumfield Nov 2014

The Drivers Of Tropical Speciation, Brian Tilston Smith, John E. Mccormack, Andrés M. Cuervo, Michael J. Hickerson, Alexandre Aleixo, Carlos Daniel Cadena, Jorge Pérez-Emán, Curtis W. Burney, Xiaoou Xie, Michael G. Harvey, Brant C. Faircloth, Travis C. Glenn, Elizabeth P. Derryberry, Jesse Prejean, Samantha Fields, Robb T. Brumfield

Faculty Publications

© 2014 Macmillan Publishers Limited. All rights reserved. Since the recognition that allopatric speciation can be induced by large-scale reconfigurations of the landscape that isolate formerly continuous populations, such as the separation of continents by plate tectonics, the uplift of mountains or the formation of large rivers, landscape change has been viewed as a primary driver of biological diversification. This process is referred to in biogeography as vicariance. In the most species-rich region of the world, the Neotropics, the sundering of populations associated with the Andean uplift is ascribed this principal role in speciation. An alternative model posits that rather …


Population Genetics Of Seaside Sparrow (Ammodramus Maritimus) Subspecies Along The Gulf Of Mexico, Stefan Woltmann, Philip C. Stouffer, Christine M.Bergeon Burns, Mark S. Woodrey, Mollie F. Cashner, Sabrina S. Taylor Nov 2014

Population Genetics Of Seaside Sparrow (Ammodramus Maritimus) Subspecies Along The Gulf Of Mexico, Stefan Woltmann, Philip C. Stouffer, Christine M.Bergeon Burns, Mark S. Woodrey, Mollie F. Cashner, Sabrina S. Taylor

Faculty Publications

Seaside Sparrows (Ammodramus maritimus) along the Gulf of Mexico are currently recognized as four subspecies, including taxa in Florida (A. m. juncicola and A. m. peninsulae) and southern Texas (Ammodramus m. sennetti), plus a widespread taxon between them (A. m. fisheri). We examined population genetic structure of this ''Gulf Coast'' clade using microsatellite and mtDNA data. Results of Bayesian analyses (STRUCTURE, GENELAND) of microsatellite data from nine locations do not entirely align with current subspecific taxonomy. Ammodramus m. sennetti from southern Texas is significantly differentiated from all other populations, but we found evidence of an admixture zone with A. m. …


A Challenge For The Seed Mixture Refuge Strategy In Bt Maize: Impact Of Cross-Pollination On An Ear-Feeding Pest, Corn Earworm, Fei Yang, David L. Kerns, Graham P. Head, B. Rogers Leonard, Ronnie Levy, Ying Niu, Fangneng Huang Nov 2014

A Challenge For The Seed Mixture Refuge Strategy In Bt Maize: Impact Of Cross-Pollination On An Ear-Feeding Pest, Corn Earworm, Fei Yang, David L. Kerns, Graham P. Head, B. Rogers Leonard, Ronnie Levy, Ying Niu, Fangneng Huang

Faculty Publications

To counter the threat of insect resistance, Bacillus thuringiensis (Bt) maize growers in the U.S. are required to plant structured non-Bt maize refuges. Concerns with refuge compliance led to the introduction of seed mixtures, also called RIB (refuge-inthe-bag), as an alternative approach for implementing refuge for Bt maize products in the U.S. Maize Belt. A major concern in RIB is cross-pollination of maize hybrids that can cause Bt proteins to be present in refuge maize kernels and negatively affect refuge insects. Here we show that a mixed planting of 5% nonBt and 95% Bt maize containing the SmartStax traits expressing …


Cry1f Resistance In Fall Armyworm Spodoptera Frugiperda: Single Gene Versus Pyramided Bt Maize, Fangneng Huang, Jawwad A. Qureshi, Robert L. Meagher, Dominic D. Reisig, Graham P. Head, David A. Andow, Xinzi Ni, David Kerns, G. David Buntin, Ying Niu, Fei Yang, Vikash Dangal Nov 2014

Cry1f Resistance In Fall Armyworm Spodoptera Frugiperda: Single Gene Versus Pyramided Bt Maize, Fangneng Huang, Jawwad A. Qureshi, Robert L. Meagher, Dominic D. Reisig, Graham P. Head, David A. Andow, Xinzi Ni, David Kerns, G. David Buntin, Ying Niu, Fei Yang, Vikash Dangal

Faculty Publications

Evolution of insect resistance to transgenic crops containing Bacillus thuringiensis (Bt) genes is a serious threat to the sustainability of this technology. However, field resistance related to the reduced efficacy of Bt maize has not been documented in any lepidopteran pest in the mainland U.S. after 18 years of intensive Bt maize planting. Here we report compelling evidence of field resistance in the fall armyworm, Spodoptera frugiperda (J.E. Smith), to Cry1F maize (TC 3507) in the southeastern region of the U.S. An F2 screen showed a surprisingly high (0.293) Cry1F resistance allele frequency in a population collected in 2011 from …


Exposure To Combustion Generated Environmentally Persistent Free Radicals Enhances Severity Of Influenza Virus Infection, Greg I. Lee, Jordy Saravia, Dahui You, Bishwas Shrestha, Sridhar Jaligama, Valerie Y. Hebert, Tammy R. Dugas, Stephania A. Cormier Oct 2014

Exposure To Combustion Generated Environmentally Persistent Free Radicals Enhances Severity Of Influenza Virus Infection, Greg I. Lee, Jordy Saravia, Dahui You, Bishwas Shrestha, Sridhar Jaligama, Valerie Y. Hebert, Tammy R. Dugas, Stephania A. Cormier

Faculty Publications

© 2014 Lee et al. Background: Exposures to elevated levels of particulate matter (PM) enhance severity of influenza virus infection in infants. The biological mechanism responsible for this phenomenon is unknown. The recent identification of environmentally persistent free radicals (EPFRs) associated with PM from a variety of combustion sources suggests its role in the enhancement of influenza disease severity. Methods: Neonatal mice (< seven days of age) were exposed to DCB230 (combustion derived PM with a chemisorbed EPFR), DCB50 (non-EPFR PM sample), or air for 30 minutes/day for seven consecutive days. Four days post-exposure, neonates were infected with influenza intranasally at 1.25 TCID50/neonate. Neonates were assessed for morbidity (% weight gain, peak pulmonary viral load, and viral clearance) and percent survival. Lungs were isolated and assessed for oxidative stress (8-isoprostanes and glutathione levels), adaptive immune response to influenza, and regulatory T cells (Tregs). The role of the EPFR was also assessed by use of transgenic mice expressing human superoxide dismutase 2. Results: Neonates exposed to EPFRs had significantly enhanced morbidity and decreased survival following influenza infection. Increased oxidative stress was also observed in EPFR exposed neonates. This correlated with increased pulmonary Tregs and dampened protective T cell responses to influenza infection. Reduction of EPFR-induced oxidative stress attenuated these effects. Conclusions: Neonatal exposure to EPFR containing PM resulted in pulmonary oxidative stress and enhanced influenza disease severity. EPFR-induced oxidative stress resulted in increased presence of Tregs in the lungs and subsequent suppression of adaptive immune response to influenza.


A Single Intramuscular Vaccination Of Mice With The Hsv-1 Vc2 Virus With Mutations In The Glycoprotein K And The Membrane Protein Ul20 Confers Full Protection Against Lethal Intravaginal Challenge With Virulent Hsv-1 And Hsv-2 Strains, Brent A. Stanfield, Jacque Stahl, Vladimir N. Chouljenko, Ramesh Subramanian, Anu Susan Charles, Ahmad A. Saied, Jason D. Walker, Konstantin G. Kousoulas Oct 2014

A Single Intramuscular Vaccination Of Mice With The Hsv-1 Vc2 Virus With Mutations In The Glycoprotein K And The Membrane Protein Ul20 Confers Full Protection Against Lethal Intravaginal Challenge With Virulent Hsv-1 And Hsv-2 Strains, Brent A. Stanfield, Jacque Stahl, Vladimir N. Chouljenko, Ramesh Subramanian, Anu Susan Charles, Ahmad A. Saied, Jason D. Walker, Konstantin G. Kousoulas

Faculty Publications

© 2014 Stanfield et al. Herpes Simplex Virus type-1 (HSV-1) and type-2 (HSV-2) establish life-long infections and cause significant orofacial and genital infections in humans. HSV-1 is the leading cause of infectious blindness in the western world. Currently, there are no available vaccines to protect against herpes simplex infections. Recently, we showed that a single intramuscular immunization with an HSV-1(F) mutant virus lacking expression of the viral glycoprotein K (gK), which prevents the virus from entering into distal axons of ganglionic neurons, conferred significant protection against either virulent HSV-1(McKrae) or HSV-2(G) intravaginal challenge in mice. Specifically, 90% of the mice …


Social Regulation Of Reproduction In Male Cichlid Fishes, Karen P. Maruska Oct 2014

Social Regulation Of Reproduction In Male Cichlid Fishes, Karen P. Maruska

Faculty Publications

© 2014 Elsevier Inc. Social interactions and relative positions within a dominance hierarchy have helped shape the evolution of reproduction in many animals. Since reproduction is crucial in all animals, and rank typically regulates access to reproductive opportunities, understanding the mechanisms that regulate socially-induced reproductive processes is extremely important. How does position in a dominance hierarchy impact an individual's reproductive behavior, morphology, and physiology? Teleost fishes, and cichlids in particular, are ideally-suited models for studying how social status influences reproduction on multiple levels of biological organization. Here I review the current knowledge on the reproductive behavioral and physiological consequences of …


Faculty Senate Newsletter, October 2014, Louisiana State University And Agricultural & Mechanical College Oct 2014

Faculty Senate Newsletter, October 2014, Louisiana State University And Agricultural & Mechanical College

LSU Faculty Senate Publications

Message from President: A prominent leader on a rather large Louisiana university recently opened his monthly letter to the campus community with an announcement, in bold-face type, that all may rejoice in the discovery that incoming students had averaged 25.82 on the ACT entrance examination. That, with two-digit decimal accuracy, while the retirement system sweeps away two-digit full-integer percentages of faculty retirement money and while more than two layers of paint peel away in almost every decaying academic building. Setting aside the obvious problems with the physical and economic conditions under which academic professionals toil, one can only wonder what …


The Early History Of Chance In Evolution, Charles H. Pence Oct 2014

The Early History Of Chance In Evolution, Charles H. Pence

Faculty Publications

Work throughout the history and philosophy of biology frequently employs ‘chance’, ‘unpredictability’, ‘probability’, and many similar terms. One common way of understanding how these concepts were introduced in evolution focuses on two central issues: the first use of statistical methods in evolution (Galton), and the first use of the concept of “objective chance” in evolution (Wright). I argue that while this approach has merit, it fails to fully capture interesting philosophical reflections on the role of chance expounded by two of Galton's students, Karl Pearson and W.F.R. Weldon. Considering a question more familiar from contemporary philosophy of biology—the relationship between …


Contributions Of Non-Traditional Meat Animals To Global Food Security And Agricultural Economy, Surendranath P. Suman, Kenneth W. Mcmillin Oct 2014

Contributions Of Non-Traditional Meat Animals To Global Food Security And Agricultural Economy, Surendranath P. Suman, Kenneth W. Mcmillin

Faculty Publications

No abstract provided.


Louisiana Agriculture Fall, 2014 Oct 2014

Louisiana Agriculture Fall, 2014

Louisiana Agriculture

No abstract provided.


Anonymization Of Dicom Electronic Medical Records For Radiation Therapy, Wayne Newhauser, Timothy Jones, Stuart Swerdloff, Warren Newhauser, Mark Cilia, Robert Carver, Andy Halloran, Rui Zhang Oct 2014

Anonymization Of Dicom Electronic Medical Records For Radiation Therapy, Wayne Newhauser, Timothy Jones, Stuart Swerdloff, Warren Newhauser, Mark Cilia, Robert Carver, Andy Halloran, Rui Zhang

Faculty Publications

Electronic medical records (EMR) and treatment plans are used in research on patient outcomes and radiation effects. In many situations researchers must remove protected health information (PHI) from EMRs. The literature contains several studies describing the anonymization of generic Digital Imaging and Communication in Medicine (DICOM) files and DICOM image sets but no publications were found that discuss the anonymization of DICOM radiation therapy plans, a key component of an EMR in a cancer clinic. In addition to this we were unable to find a commercial software tool that met the minimum requirements for anonymization and preservation of data integrity …


Paternally Expressed Peg3 Controls Maternally Expressed Zim1 As A Trans Factor, An Ye, Hongzhi He, Joomyeong Kim Sep 2014

Paternally Expressed Peg3 Controls Maternally Expressed Zim1 As A Trans Factor, An Ye, Hongzhi He, Joomyeong Kim

Faculty Publications

© 2014 Ye et al. The expression of two adjacent imprinted genes, Peg3 and Zim1, is inversely correlated: down-regulation of Peg3 coinciding with up-regulation of Zim1. The current study characterized this inverse correlation using a mutant allele targeting Peg3. According to the results, the mutation on the paternal allele of Peg3 resulted in a dramatic increase in the transcription levels of the maternal allele of Zim1, suggesting the involvement of unknown trans factors in this trans-allelic event. Subsequent ChIP experiments revealed that the protein encoded by Peg3 itself binds to the zinc finger exon of Zim1, which is modified with …


Responses Of Sympatric Karenia Brevis, Prorocentrum Minimum, And Heterosigma Akashiwo To The Exposure Of Crude Oil, Koray Özhan, Sibel Bargu Sep 2014

Responses Of Sympatric Karenia Brevis, Prorocentrum Minimum, And Heterosigma Akashiwo To The Exposure Of Crude Oil, Koray Özhan, Sibel Bargu

Faculty Publications

Impacts of the Deepwater Horizon oil spill on phytoplankton, particularly, the tolerability and changes to the toxin profiles of harmful toxic algal species remain unknown. The degree to which oil-affected sympatric Karenia brevis, Prorocentrum minimum, and Heterosigma akashiwo, all of which are ecologically important species in the Gulf of Mexico, was investigated. Comparison of their tolerability to that of non-toxic species showed that the toxin-production potential of harmful species does not provide a selective advantage. Investigated toxin profiles for K. brevis and P. minimum demonstrated an increase in toxin productivity at the lowest crude oil concentration (0.66 mg L−1 …


Gibbon Genome And The Fast Karyotype Evolution Of Small Apes, Lucia Carbone, R. Alan Harris, Sante Gnerre, Krishna R. Veeramah, Belen Lorente-Galdos, John Huddleston, Thomas J. Meyer, Javier Herrero, Christian Roos, Bronwen Aken, Fabio Anaclerio, Nicoletta Archidiacono, Carl Baker, Daniel Barrell, Mark A. Batzer, Kathryn Beal, Antoine Blancher, Craig L. Bohrson, Markus Brameier, Michael S. Campbell, Oronzo Capozzi, Claudio Casola, Giorgia Chiatante, Andrew Cree, Annette Damert, Pieter J. De Jong, Laura Dumas, Marcos Fernandez-Callejo, Paul Flicek, Nina V. Fuchs, Ivo Gut, Marta Gut, Matthew W. Hahn, Jessica Hernandez-Rodriguez, Ladeana W. Hillier, Robert Hubley, Bianca Ianc, Zsuzsanna Izsvák, Nina G. Jablonski, Laurel M. Johnstone, Anis Karimpour-Fard, Miriam K. Konkel, Dennis Kostka, Nathan H. Lazar, Sandra L. Lee, Lora R. Lewis, Yue Liu, Devin P. Locke, Swapan Mallick, Fernando L. Mendez, Matthieu Muffato, Lynne V. Nazareth, Kimberly A. Nevonen, Majesta O'Bleness, Cornelia Ochis, Duncan T. Odom, Katherine S. Pollard, Javier Quilez, David Reich, Mariano Rocchi, Gerald G. Schumann, Stephen Searle, James M. Sikela, Gabriella Skollar, Arian Smit, Kemal Sonmez, Boudewijn Ten Hallers, Elizabeth Terhune, Gregg W. C. Thomas, Brygg Ullmer, Mario Ventura, Jerilyn A. Walker, Jeffrey D. Wall, Lutz Walter, Michelle C. Ward, Sarah J. Wheelan, Christopher W. Whelan, Simon White, Larry J. Wilhelm, August E. Woerner, Mark Yandell, Baoli Zhu, Michael F. Hammer, Tomas Marques-Bonet, Evan E. Eichler, Lucinda Fulton, Catrina Fronick, Donna M. Muzny, Wesley C. Warren, Kim C. Worley, Jeffrey Rogers, Richard K. Wilson, Richard A. Gibbs Sep 2014

Gibbon Genome And The Fast Karyotype Evolution Of Small Apes, Lucia Carbone, R. Alan Harris, Sante Gnerre, Krishna R. Veeramah, Belen Lorente-Galdos, John Huddleston, Thomas J. Meyer, Javier Herrero, Christian Roos, Bronwen Aken, Fabio Anaclerio, Nicoletta Archidiacono, Carl Baker, Daniel Barrell, Mark A. Batzer, Kathryn Beal, Antoine Blancher, Craig L. Bohrson, Markus Brameier, Michael S. Campbell, Oronzo Capozzi, Claudio Casola, Giorgia Chiatante, Andrew Cree, Annette Damert, Pieter J. De Jong, Laura Dumas, Marcos Fernandez-Callejo, Paul Flicek, Nina V. Fuchs, Ivo Gut, Marta Gut, Matthew W. Hahn, Jessica Hernandez-Rodriguez, Ladeana W. Hillier, Robert Hubley, Bianca Ianc, Zsuzsanna Izsvák, Nina G. Jablonski, Laurel M. Johnstone, Anis Karimpour-Fard, Miriam K. Konkel, Dennis Kostka, Nathan H. Lazar, Sandra L. Lee, Lora R. Lewis, Yue Liu, Devin P. Locke, Swapan Mallick, Fernando L. Mendez, Matthieu Muffato, Lynne V. Nazareth, Kimberly A. Nevonen, Majesta O'Bleness, Cornelia Ochis, Duncan T. Odom, Katherine S. Pollard, Javier Quilez, David Reich, Mariano Rocchi, Gerald G. Schumann, Stephen Searle, James M. Sikela, Gabriella Skollar, Arian Smit, Kemal Sonmez, Boudewijn Ten Hallers, Elizabeth Terhune, Gregg W. C. Thomas, Brygg Ullmer, Mario Ventura, Jerilyn A. Walker, Jeffrey D. Wall, Lutz Walter, Michelle C. Ward, Sarah J. Wheelan, Christopher W. Whelan, Simon White, Larry J. Wilhelm, August E. Woerner, Mark Yandell, Baoli Zhu, Michael F. Hammer, Tomas Marques-Bonet, Evan E. Eichler, Lucinda Fulton, Catrina Fronick, Donna M. Muzny, Wesley C. Warren, Kim C. Worley, Jeffrey Rogers, Richard K. Wilson, Richard A. Gibbs

Faculty Publications

©2014 Macmillan Publishers Limited. All rights reserved. Gibbons are small arboreal apes that display an accelerated rate of evolutionary chromosomal rearrangement and occupy a key node in the primate phylogeny between Old World monkeys and great apes. Here we present the assembly and analysis of a northern white-cheeked gibbon (Nomascus leucogenys) genome. We describe the propensity for a gibbon-specific retrotransposon (LAVA) to insert into chromosome segregation genes and alter transcription by providing a premature termination site, suggesting a possible molecular mechanism for the genome plasticity of the gibbon lineage. We further show that the gibbon genera (Nomascus, Hylobates, Hoolock and …


Space Radiation: The Number One Risk To Astronaut Health Beyond Low Earth Orbit, Jeffery C. Chancellor, Graham B.I. Scott, Jeffrey P. Sutton Sep 2014

Space Radiation: The Number One Risk To Astronaut Health Beyond Low Earth Orbit, Jeffery C. Chancellor, Graham B.I. Scott, Jeffrey P. Sutton

Faculty Publications

Projecting a vision for space radiobiological research necessitates understanding the nature of the space radiation environment and how radiation risks influence mission planning, timelines and operational decisions. Exposure to space radiation increases the risks of astronauts developing cancer, experiencing central nervous system (CNS) decrements, exhibiting degenerative tissue effects or developing acute radiation syndrome. One or more of these deleterious health effects could develop during future multi-year space exploration missions beyond low Earth orbit (LEO). Shielding is an effective countermeasure against solar particle events (SPEs), but is ineffective in protecting crew members from the biological impacts of fast moving, highly-charged galactic …


Transcriptional Profiles Of Bovine In Vivo Pre-Implantation Development, Zongliang Jiang, Jiangwen Sun, Hong Dong, Oscar Luo, Xinbao Zheng, Craig Obergfell, Yong Tang, Jinbo Bi, Rachel O'Neill, Yijun Ruan, Jingbo Chen, Xiuchun Tian Sep 2014

Transcriptional Profiles Of Bovine In Vivo Pre-Implantation Development, Zongliang Jiang, Jiangwen Sun, Hong Dong, Oscar Luo, Xinbao Zheng, Craig Obergfell, Yong Tang, Jinbo Bi, Rachel O'Neill, Yijun Ruan, Jingbo Chen, Xiuchun Tian

Faculty Publications

© 2014 Jiang et al.; licensee BioMed Central Ltd. Background: During mammalian pre-implantation embryonic development dramatic and orchestrated changes occur in gene transcription. The identification of the complete changes has not been possible until the development of the Next Generation Sequencing Technology.Results: Here we report comprehensive transcriptome dynamics of single matured bovine oocytes and pre-implantation embryos developed in vivo. Surprisingly, more than half of the estimated 22,000 bovine genes, 11,488 to 12,729 involved in more than 100 pathways, is expressed in oocytes and early embryos. Despite the similarity in the total numbers of genes expressed across stages, the nature of …


Faculty Senate Newsletter, September 2014, Louisiana State University And Agricultural & Mechanical College Sep 2014

Faculty Senate Newsletter, September 2014, Louisiana State University And Agricultural & Mechanical College

LSU Faculty Senate Publications

Message from President: One of the favorite processes among those who study contemporary culture is disaggregation, the breaking apart of previously bundled ideas, resources, or experiences. Living in what might be described as the “à la carte” age requires a readiness to accept a degree of genial incoherence and thereby to increase the range and economy of selection at the expense of getting any reasonable facsimile of the big picture. Musical albums become downloaded singles; meals dissipate into fats, “carbs,” sodium, sugar, and an assortment of nutrients; books centrifugalize into first articles, then abstracts, then executive summaries, and finally into …


Relative Importance Of Environmental, Geographic, And Spatial Variables On Zooplankton Metacommunities, Tad Dallas, John M. Drake Sep 2014

Relative Importance Of Environmental, Geographic, And Spatial Variables On Zooplankton Metacommunities, Tad Dallas, John M. Drake

Faculty Publications

© 2014 Dallas and Drake. Understanding the factors responsible for structuring ecological communities is a central goal in community ecology. Previous work has focused on determining the relative roles of two classes of variables (e.g., spatial and environmental) on community composition. However, this approach may ignore the disproportionate impact of variables within classes, and is often confounded by spatial autocorrelation leading to collinearity among variables of different classes. Here, we combine pattern-based metacommunity and machine learning analyses to characterize metacommunity structure of zooplankton from lakes in the northeast United States and to identify environmental, spatial, and geographic covariates associated with …


The Association Of The Vanin-1 N131s Variant With Blood Pressure Is Mediated By Endoplasmic Reticulum-Associated Degradation And Loss Of Function, Ya Juan Wang, Bamidele O. Tayo, Anupam Bandyopadhyay, Heming Wang, Tao Feng, Nora Franceschini, Hua Tang, Jianmin Gao, Yun Ju Sung, Robert C. Elston, Scott M. Williams, Richard S. Cooper, Ting Wei Mu, Xiaofeng Zhu, Daniel Levy Sep 2014

The Association Of The Vanin-1 N131s Variant With Blood Pressure Is Mediated By Endoplasmic Reticulum-Associated Degradation And Loss Of Function, Ya Juan Wang, Bamidele O. Tayo, Anupam Bandyopadhyay, Heming Wang, Tao Feng, Nora Franceschini, Hua Tang, Jianmin Gao, Yun Ju Sung, Robert C. Elston, Scott M. Williams, Richard S. Cooper, Ting Wei Mu, Xiaofeng Zhu, Daniel Levy

Faculty Publications

High blood pressure (BP) is the most common cardiovascular risk factor worldwide and a major contributor to heart disease and stroke. We previously discovered a BP-associated missense SNP (single nucleotide polymorphism)–rs2272996–in the gene encoding vanin-1, a glycosylphosphatidylinositol (GPI)-anchored membrane pantetheinase. In the present study, we first replicated the association of rs2272996 and BP traits with a total sample size of nearly 30,000 individuals from the Continental Origins and Genetic Epidemiology Network (COGENT) of African Americans (P = 0.01). This association was further validated using patient plasma samples; we observed that the N131S mutation is associated with significantly lower plasma vanin-1 …


3-D Stochastic Micropolar And Magneto-Micropolar Fluid Systems With Non-Lipschitz Multiplicative Noise, Kazuo Yamazaki Sep 2014

3-D Stochastic Micropolar And Magneto-Micropolar Fluid Systems With Non-Lipschitz Multiplicative Noise, Kazuo Yamazaki

Communications on Stochastic Analysis

No abstract provided.


Effects Of Oil On Terrestrial Vertebrates: Predicting Impacts Of The Macondo Blowout, Christine M.Bergeon Burns, Jill A. Olin, Philip C. Stouffer, Sabrina S. Taylor, Stefan Woltmann Sep 2014

Effects Of Oil On Terrestrial Vertebrates: Predicting Impacts Of The Macondo Blowout, Christine M.Bergeon Burns, Jill A. Olin, Philip C. Stouffer, Sabrina S. Taylor, Stefan Woltmann

Faculty Publications

In addition to external oiling, marine oil spills may affect vertebrate animals through degradation of habitat; alterations in food web structure; and contamination of resources by toxic compounds, including polycyclic aromatic hydrocarbons. These processes are not well understood for vertebrates breeding and foraging in terrestrial ecosystems affected by oil, such as coastal marshes that were heavily oiled following the 2010 Macondo oil spill. Here, we review what is known about the ecological and physiological effects of oil exposure on vertebrates in general. We then apply these concepts to salt-marsh vertebrates, with special reference to our ongoing monitoring of impacts and …


Tectonics, Topography, And River System Transition In East Tibet: Insights From The Sedimentary Record In Taiwan, Qing Lan, Yi Yan, Chi Yue Huang, Peter D. Clift, Xuejie Li, Wenhuang Chen, Xingchang Zhang, Mengming Yu Sep 2014

Tectonics, Topography, And River System Transition In East Tibet: Insights From The Sedimentary Record In Taiwan, Qing Lan, Yi Yan, Chi Yue Huang, Peter D. Clift, Xuejie Li, Wenhuang Chen, Xingchang Zhang, Mengming Yu

Faculty Publications

©2014. American Geophysical Union. The Cenozoic in East Asia is marked by major changes in tectonics, landscapes, and river systems, although the timing and nature of such changes remains disputed. We investigate the geochemistry and neodymium isotope character of Cenozoic mudstones spanning the breakup unconformity in the Western Foothills of Taiwan in order to constrain erosion and drainage development in southern China during the opening of the South China Sea. The La/Lu, Eu/Eu∗, Th/Sc, Th/La, Cr/Th, and eNd values in these rocks show an abrupt change between ∼31 and 25 Ma. Generally the higher eNd values in sediments deposited prior …


Effects Of Caste On The Expression Of Genes Associated With Septic Injury And Xenobiotic Exposure In The Formosan Subterranean Termite, Claudia Husseneder, Dawn M. Simms Aug 2014

Effects Of Caste On The Expression Of Genes Associated With Septic Injury And Xenobiotic Exposure In The Formosan Subterranean Termite, Claudia Husseneder, Dawn M. Simms

Faculty Publications

As social insects, termites live in densely populated colonies with specialized castes under conditions conducive to microbial growth and transmission. Furthermore, termites are exposed to xenobiotics in soil and their lignocellulose diet. Therefore, termites are valuable models for studying gene expression involved in response to septic injury, immunity and detoxification in relation to caste membership. In this study, workers and soldiers of the Formosan subterranean termite, Coptotermes formosanus, were challenged by bacterial injection or by no-choice feeding with a sublethal concentration (0.5%) of phenobarbital. Constitutive and induced expression of six putative immune response genes (two encoding for lectin-like proteins, one …


Cdk1 Promotes Cytokinesis In Fission Yeast Through Activation Of The Septation Initiation Network, Nicole Rachfall, Alyssa E. Johnson, Sapna Mehta, Jun Song Chen, Kathleen L. Gould Aug 2014

Cdk1 Promotes Cytokinesis In Fission Yeast Through Activation Of The Septation Initiation Network, Nicole Rachfall, Alyssa E. Johnson, Sapna Mehta, Jun Song Chen, Kathleen L. Gould

Faculty Publications

In Schizosaccharomyces pombe, late mitotic events are coordinated with cytokinesis by the septation initiation network (SIN), an essential spindle pole body (SPB)-associated kinase cascade, which controls the formation, maintenance, and constriction of the cytokinetic ring. It is not fully understood how SIN initiation is temporally regulated, but it depends on the activation of the GTPase Spg1, which is inhibited during interphase by the essential bipartite GTPase-activating protein Byr4-Cdc16. Cells are particularly sensitive to the modulation of Byr4, which undergoes cell cycle-dependent phosphorylation presumed to regulate its function. Polo-like kinase, which promotes SIN activation, is partially responsible for Byr4 phosphorylation. Here …


High-Throughput Targeted Repeat Element Bisulfite Sequencing (Ht-Trebs): Genome-Wide Dna Methylation Analysis Of Iap Ltr Retrotransposon, Muhammad B. Ekram, Joomyeong Kim Jul 2014

High-Throughput Targeted Repeat Element Bisulfite Sequencing (Ht-Trebs): Genome-Wide Dna Methylation Analysis Of Iap Ltr Retrotransposon, Muhammad B. Ekram, Joomyeong Kim

Faculty Publications

In vertebrates, DNA methylation-mediated repression of retrotransposons is essential for the maintenance of genomic integrity. In the current study, we developed a technique termed HT-TREBS (High-Throughput Targeted Repeat Element Bisulfite Sequencing). This technique is designed to measure the DNA methylation levels of individual loci of any repeat families with next-generation sequencing approaches. To test the feasibility of HT-TREBS, we analyzed the DNA methylation levels of the IAP LTR family using a set of 12 different genomic DNA isolated from the brain, liver and kidney of 4 one-weekold littermates of the mouse strain C57BL/6N. This technique has successfully generated the CpG …


Chemicals Facilitating Reprogramming: Targeting The Sam Binding Site To Identify Novel Methyltransferase Inhibitors, Jeong Do Kim, Jong S. Rim, Robert B. Crochet, Yong Hwan Lee, Jaroslaw Staszkiewicz, Ru Gao, Kenneth J. Eilertsen Jul 2014

Chemicals Facilitating Reprogramming: Targeting The Sam Binding Site To Identify Novel Methyltransferase Inhibitors, Jeong Do Kim, Jong S. Rim, Robert B. Crochet, Yong Hwan Lee, Jaroslaw Staszkiewicz, Ru Gao, Kenneth J. Eilertsen

Faculty Publications

© 2014 John Wiley & Sons, Ltd. Reprogramming of somatic cells to a pluripotent state has been achieved by viral-mediated transduction of defined transcription factors. In order to achieve the goal of clinical application, it is necessary to overcome a variety of limitations, including poor reprogramming efficiencies and viral integration. One strategy is to identify small-molecule inhibitors that can improve reprogramming efficiency or replace defined transcription factors. Several reports have demonstrated that modulation of chromatin-modifying enzymes can significantly improve reprogramming efficiency. Key enzymes include DNA and histone methyltransferases, which utilize the cofactor S-adenosyl methionine (SAM) to transfer a methyl group. …