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Advances In Tropical Climatology–A Review, Flávia D.S. Moraes, Craig Ramseyer, Paul W. Miller, Jill C. Trepanier Jan 2025

Advances In Tropical Climatology–A Review, Flávia D.S. Moraes, Craig Ramseyer, Paul W. Miller, Jill C. Trepanier

Faculty Publications

Understanding tropical climatology is essential to comprehending the atmospheric connections between the tropics and extratropical latitudes weather and climate events. In this review paper, we emphasize the advances in key areas of tropical climatology knowledge since the end of the 20th century and offer a summary, assessment, and discussion of previously published literature. Among the key areas analyzed here, we explore the advances in tropical oceanic and atmospheric variability, such as El Niño–Southern Oscillation and the Madden-Julian Oscillation, and how those teleconnection events have helped us to better understand variabilities in tropical monsoons, tropical cyclones, and drought events. We also …

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Vertebrate Fossils Of Louisiana, Suyin Ting, Lorene E. Smith, Connor D. White, Irene Martí Gil Jan 2025

Vertebrate Fossils Of Louisiana, Suyin Ting, Lorene E. Smith, Connor D. White, Irene Martí Gil

Special Publications of the Museum of Natural Science

No abstract provided.

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An Early Web History Of Vaccine Skeptical Digital Rhetorics, Miles C. Coleman, Will Mari Jan 2025

An Early Web History Of Vaccine Skeptical Digital Rhetorics, Miles C. Coleman, Will Mari

Faculty Publications

Vaccine hesitancy is a public health threat stoked by vaccine skeptical rhetorics that circulate via the Web. While there is a body of work that studies the digital rhetorical tactics of vaccine skeptics, most of this work focuses on the Web rhetorics of the “Web 2.0” era, leaving the “Web 1.0” era relatively understudied and, in turn, foreclosing opportunities to look back before moving forward in the current moment. In efforts to yield glimpses into the antecedents of digital culture that have shaped contemporary vaccine skeptical discourses, in this article, we draw on systematically sourced website “snapshots” of vaccine skeptical …

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Rheological Characterization And Printability Of Sodium Alginate–Gelatin Hydrogel For 3d Cultures And Bioprinting, Mohan Kumar Dey, Ram V. Devireddy Jan 2025

Rheological Characterization And Printability Of Sodium Alginate–Gelatin Hydrogel For 3d Cultures And Bioprinting, Mohan Kumar Dey, Ram V. Devireddy

Faculty Publications

The development of biocompatible hydrogels for 3D bioprinting is essential for creating functional tissue models and advancing preclinical drug testing. This study investigates the formulation, printability, mechanical properties, and biocompatibility of a novel Alg-Gel hydrogel blend (alginate and gelatin) for use in extrusion-based 3D bioprinting. A range of hydrogel compositions were evaluated for their rheological behavior, including shear-thinning properties, storage modulus, and compressive modulus, which are crucial for maintaining structural integrity during printing and supporting cell viability. The printability assessment of the 7% alginate–8% gelatin hydrogel demonstrated that the 27T tapered needle achieved the highest normalized Printability Index (POInormalized = …

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Glucagon-Like Peptide-1 Receptor Agonist-Based Agents And Weight Loss Composition: Filling The Gaps, Robert L. Dubin, Steven B. Heymsfield, Eric Ravussin, Frank L. Greenway Dec 2024

Glucagon-Like Peptide-1 Receptor Agonist-Based Agents And Weight Loss Composition: Filling The Gaps, Robert L. Dubin, Steven B. Heymsfield, Eric Ravussin, Frank L. Greenway

Clinical Research Faculty Publications

Excess adiposity is at the root of type 2 diabetes (T2D). Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as first-line treatments for T2D based on significant weight loss results. The composition of weight loss using most diets consists of < 25% fat-free mass (FFM) loss, with the remainder from fat stores. Higher amounts of weight loss (achieved with metabolic bariatric surgery) result in greater reductions in FFM. Our aim was to assess the impact that GLP-1RA-based treatments have on FFM. We analysed studies that reported changes in FFM with the following agents: exenatide, liraglutide, semaglutide, and the dual incretin receptor agonist tirzepatide. We performed an analysis of various weight loss interventions to provide a reference for expected changes in FFM. We evaluated studies using dual-energy X-ray absorptiometry (DXA) for measuring FFM (a crude surrogate for skeletal muscle). In evaluating the composition of weight loss, the percentage lost as fat-free mass (%FFML) was equal to ΔFFM/total weight change. The %FFML using GLP-1RA-based agents was between 20% and 40%. In the 28 clinical trials evaluated, the proportion of FFM loss was highly variable, but the majority reported %FFML exceeding 25%. Our review was limited to small substudies and the use of DXA, which does not measure skeletal muscle mass directly. Since FFM contains a variable amount of muscle (approximately 55%), this indirect measure may explain the heterogeneity in the data. Assessing quantity and quality of skeletal muscle using advanced imaging (magnetic resonance imaging) with functional testing will help fill the gaps in our current understanding.

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Multiomics Analysis To Explore Blood Metabolite Biomarkers In An Alzheimer’S Disease Neuroimaging Initiative Cohort, Takaki Oka, Yuki Matsuzawa, Momoka Tsuneyoshi, Yoshitaka Nakamura, Ken Aoshima, Hiroshi Tsugawa, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles Decarli, Bret Borowski Dec 2024

Multiomics Analysis To Explore Blood Metabolite Biomarkers In An Alzheimer’S Disease Neuroimaging Initiative Cohort, Takaki Oka, Yuki Matsuzawa, Momoka Tsuneyoshi, Yoshitaka Nakamura, Ken Aoshima, Hiroshi Tsugawa, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles Decarli, Bret Borowski

Clinical Research Faculty Publications

Alzheimer's disease (AD) is a neurodegenerative disease that commonly causes dementia. Identifying biomarkers for the early detection of AD is an emerging need, as brain dysfunction begins two decades before the onset of clinical symptoms. To this end, we reanalyzed untargeted metabolomic mass spectrometry data from 905 patients enrolled in the AD Neuroimaging Initiative (ADNI) cohort using MS-DIAL, with 1,304,633 spectra of 39,108 unique biomolecules. Metabolic profiles of 93 hydrophilic metabolites were determined. Additionally, we integrated targeted lipidomic data (4873 samples from 1524 patients) to explore candidate biomarkers for predicting progressive mild cognitive impairment (pMCI) in patients diagnosed with AD …

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Tailoring Ipm Plans To Fight A Cloaked Pest: Helping Smallholder Farmers Combat The Sweetpotato Weevil In Sub-Saharan Africa, Chad A. Keyser, Frederick S. Walters, Haley Turner, Elka Armstrong, Jeff Davis, Brooke Bissinger, Brant Johnson, Agnes Alajo, Paul Musana, Joseph Odongo, Benard Yada, Milton A. Otema Dec 2024

Tailoring Ipm Plans To Fight A Cloaked Pest: Helping Smallholder Farmers Combat The Sweetpotato Weevil In Sub-Saharan Africa, Chad A. Keyser, Frederick S. Walters, Haley Turner, Elka Armstrong, Jeff Davis, Brooke Bissinger, Brant Johnson, Agnes Alajo, Paul Musana, Joseph Odongo, Benard Yada, Milton A. Otema

Faculty Publications

Africa accounts for a significant portion of the world’s sweetpotato production where it is widely grown as a staple crop. In sub-Saharan Africa (SSA), sweetpotato serves as an important year-round source of calories and nutrition, a form of income for smallholder and pre-commercial farmers, and is increasingly used as silage for animal feed. However, yield per hectare is considerably lower in SSA than from other regions primarily due to sweetpotato weevils (SPW, Cylas spp., Coleoptera: Brentidae). Weevil feeding causes physical damage to the root and can induce chemical responses that give the storage root a bitter taste, both of which …

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Early Life Energy Balance: The Development Of Infant Energy Expenditure And Intake In The Context Of Obesity, Emily W. Flanagan, Leanne M. Redman Dec 2024

Early Life Energy Balance: The Development Of Infant Energy Expenditure And Intake In The Context Of Obesity, Emily W. Flanagan, Leanne M. Redman

Clinical Research Faculty Publications

Purpose of Review: This review aims to provide a summary of the current knowledge on measurement tools and most recent evidence for prenatal and postnatal modulators of energy balance in young infants. Recent Findings: The prevention of pediatric obesity depends upon curating the perfect imbalance of energy intake to energy expenditure, taking into consideration the energy needs for healthy growth. We summarize the recent evidence for the programming of fetal and infant metabolism influenced by maternal preconception health, prenatal metabolic milieu, and physical activity behaviors. In the early postnatal environment, caregiver feeding behaviors shape the extent of energy imbalance through …

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Estrogen Signaling In The Dorsal Raphe Regulates Binge-Like Drinking In Mice, Valeria C. Torres Irizarry, Bing Feng, Xiaohua Yang, Nirali Patel, Sarah Schaul, Lucas Ibrahimi, Hui Ye, Pei Luo, Leslie Carrillo-Sáenz, Penghua Lai, Maya Kota, Devin Dixit, Chunmei Wang, Amy W. Lasek, Yanlin He, Pingwen Xu Dec 2024

Estrogen Signaling In The Dorsal Raphe Regulates Binge-Like Drinking In Mice, Valeria C. Torres Irizarry, Bing Feng, Xiaohua Yang, Nirali Patel, Sarah Schaul, Lucas Ibrahimi, Hui Ye, Pei Luo, Leslie Carrillo-Sáenz, Penghua Lai, Maya Kota, Devin Dixit, Chunmei Wang, Amy W. Lasek, Yanlin He, Pingwen Xu

Division of Basic Science Faculty Publications

Estrogens promote binge alcohol drinking and contribute to sex differences in alcohol use disorder. However, the mechanisms are largely unknown. This study aims to test if estrogens act on 5-hydroxytryptamine neurons in the dorsal raphe nucleus (5-HTDRN) to promote binge drinking. We found that female mice drank more alcohol than male mice in chronic drinking in the dark (DID) tests. This sex difference was associated with distinct alterations in mRNA expression of estrogen receptor α (ERα) and 5-HT-related genes in the DRN, suggesting a potential role of estrogen/ERs/5-HT signaling. In supporting this view, 5-HTDRN neurons from naïve male mice had …

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Gna13 Suppresses Proliferation Of Er+ Breast Cancer Cells Via Erα Dependent Upregulation Of The Myc Oncogene, Lalitha Vaishnavi Subramanyan, Suhail Ahmed Kabeer Rasheed, Lijin Wang, Sujoy Ghosh, Michelle Shi Ning Ong, Manikandan Lakshmanan, Mei Wang, Patrick J. Casey Dec 2024

Gna13 Suppresses Proliferation Of Er+ Breast Cancer Cells Via Erα Dependent Upregulation Of The Myc Oncogene, Lalitha Vaishnavi Subramanyan, Suhail Ahmed Kabeer Rasheed, Lijin Wang, Sujoy Ghosh, Michelle Shi Ning Ong, Manikandan Lakshmanan, Mei Wang, Patrick J. Casey

Division of Basic Science Faculty Publications

GNA13 (Gα13) is one of two alpha subunit members of the G12/13 family of heterotrimeric G-proteins which mediate signaling downstream of GPCRs. It is known to be essential for embryonic development and vasculogenesis and has been increasingly shown to be involved in mediating several steps of cancer progression. Recent studies found that Gα13 can function as an oncogene and contributes to progression and metastasis of multiple tumor types, including ovarian, head and neck and prostate cancers. In most cases, Gα12 and Gα13, as closely related α-subunits in the subfamily, have similar cellular roles. However, in recent years their differences in …

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Exercise Therapy Rescues Skeletal Muscle Dysfunction And Exercise Intolerance In Cardiometabolic Hfpef, Heather Quiriarte, Robert C. Noland, James E. Stampley, Gregory Davis, Zhen Li, Eunhan Cho, Youyoung Kim, Jake Doiron, Guillaume Spielmann, Sujoy Ghosh, Sanjiv J. Shah, Brian A. Irving, David J. Lefer, Timothy D. Allerton Dec 2024

Exercise Therapy Rescues Skeletal Muscle Dysfunction And Exercise Intolerance In Cardiometabolic Hfpef, Heather Quiriarte, Robert C. Noland, James E. Stampley, Gregory Davis, Zhen Li, Eunhan Cho, Youyoung Kim, Jake Doiron, Guillaume Spielmann, Sujoy Ghosh, Sanjiv J. Shah, Brian A. Irving, David J. Lefer, Timothy D. Allerton

Division of Basic Science Faculty Publications

Exercise intolerance, a hallmark of heart failure with preserved ejection fraction (HFpEF) exacerbated by obesity, involves unclear mechanisms related to skeletal muscle metabolism. In a “2-hit” model of HFpEF, we investigated the ability of exercise therapy (voluntary wheel running) to reverse skeletal muscle dysfunction and exercise intolerance. Using state-of-the-art metabolic cages and a multiomic approach, we demonstrate exercise can rescue dysfunctional skeletal muscle lipid and branched-chain amino acid oxidation and restore exercise capacity in mice with cardiometabolic HFpEF. These results underscore the importance of skeletal muscle metabolism to improve exercise intolerance in HFpEF.

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The Impact Of Exercise On Gene Regulation In Association With Complex Trait Genetics, Nikolai G. Vetr, Nicole R. Gay, Joshua N. Adkins, Brent G. Albertson, David Amar, Mary Anne S. Amper, Jose Juan Almagro Armenteros, Euan Ashley, Julian Avila-Pacheco, Dam Bae, Ali Tugrul Balci, Marcas Bamman, Nasim Bararpour, Elisabeth R. Barton, Pierre M. Jean Beltran, Bryan C. Bergman, Daniel H. Bessesen, Sue C. Bodine, Frank W. Booth, Brian Bouverat, Thomas W. Buford, Charles F. Burant, Tiziana Caputo, Steven Carr, Toby L. Chambers, Clarisa Chavez, Maria Chikina, Roxanne Chiu, Michael Cicha, Clary B. Clish, Paul M. Coen, Dan Cooper, Elaine Cornell, Gary Cutter Dec 2024

The Impact Of Exercise On Gene Regulation In Association With Complex Trait Genetics, Nikolai G. Vetr, Nicole R. Gay, Joshua N. Adkins, Brent G. Albertson, David Amar, Mary Anne S. Amper, Jose Juan Almagro Armenteros, Euan Ashley, Julian Avila-Pacheco, Dam Bae, Ali Tugrul Balci, Marcas Bamman, Nasim Bararpour, Elisabeth R. Barton, Pierre M. Jean Beltran, Bryan C. Bergman, Daniel H. Bessesen, Sue C. Bodine, Frank W. Booth, Brian Bouverat, Thomas W. Buford, Charles F. Burant, Tiziana Caputo, Steven Carr, Toby L. Chambers, Clarisa Chavez, Maria Chikina, Roxanne Chiu, Michael Cicha, Clary B. Clish, Paul M. Coen, Dan Cooper, Elaine Cornell, Gary Cutter

Clinical Research Faculty Publications

Endurance exercise training is known to reduce risk for a range of complex diseases. However, the molecular basis of this effect has been challenging to study and largely restricted to analyses of either few or easily biopsied tissues. Extensive transcriptome data collected across 15 tissues during exercise training in rats as part of the Molecular Transducers of Physical Activity Consortium has provided a unique opportunity to clarify how exercise can affect tissue-specific gene expression and further suggest how exercise adaptation may impact complex disease-associated genes. To build this map, we integrate this multi-tissue atlas of gene expression changes with gene-disease …

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Metabarcoding The Arctic Ocean Helps Reveal Its Hidden Microbial Community Composition, Rafet Çağrı Öztürk, Yahya Terzi, Sheila Rodríguez-Machado, Ersan Başar, Ali Muzaffer Feyzioğlu, Dilek Ustaoğlu, Ertuğrul Ağırbaş, Prosanta Chakrabarty Dec 2024

Metabarcoding The Arctic Ocean Helps Reveal Its Hidden Microbial Community Composition, Rafet Çağrı Öztürk, Yahya Terzi, Sheila Rodríguez-Machado, Ersan Başar, Ali Muzaffer Feyzioğlu, Dilek Ustaoğlu, Ertuğrul Ağırbaş, Prosanta Chakrabarty

Faculty Publications

The Arctic Ocean supports a unique and dynamic microbial community, yet its composition, structure, and response to environmental shifts remain incompletely understood. In this study, 16S rRNA gene metabarcoding (targeting the V3-V4 and V4-V5 hypervariable regions) was used to assess surface water microbial diversity across 20 stations in the Barents Sea, focusing on latitudinal variations within two contrasting current systems: the West Spitsbergen Current (WSC) and the East Spitsbergen Current (ESC). Our results showed that the microbial community is dominated by three primary families—Pseudoalteromonadaceae, Moraxellaceae, and Flavobacteriaceae (14.20%). Comparative analysis of the V3-V4 and V4-V5 regions reveals that each region …

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Identification And Expression Analysis Of Phosphate Transporter 1 (Pht1) Genes In The Highly Phosphorus-Use-Efficient Hakea Prostrata (Proteaceae), Benjamin J. Nestor, Toby Bird, Anita A. Severn-Ellis, Philipp E. Bayer, Kosala Ranathunge, M. Asaduzzaman Prodhan, Maheshi Dassanayake, Jacqueline Batley, David Edwards, Hans Lambers, Patrick M. Finnegan Dec 2024

Identification And Expression Analysis Of Phosphate Transporter 1 (Pht1) Genes In The Highly Phosphorus-Use-Efficient Hakea Prostrata (Proteaceae), Benjamin J. Nestor, Toby Bird, Anita A. Severn-Ellis, Philipp E. Bayer, Kosala Ranathunge, M. Asaduzzaman Prodhan, Maheshi Dassanayake, Jacqueline Batley, David Edwards, Hans Lambers, Patrick M. Finnegan

Faculty Publications

Heavy and costly use of phosphorus (P) fertiliser is often needed to achieve high crop yields, but only a small amount of applied P fertiliser is available to most crop plants. Hakea prostrata (Proteaceae) is endemic to the P-impoverished landscape of southwest Australia and has several P-saving traits. We identified 16 members of the Phosphate Transporter 1 (PHT1) gene family (HpPHT1;1-HpPHT1;12d) in a long-read genome assembly of H. prostrata. Based on phylogenetics, sequence structure and expression patterns, we classified HpPHT1;1 as potentially involved in Pi uptake from soil and HpPHT1;8 and HpPHT1;9 as potentially involved in Pi uptake and root-to-shoot …

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Cop5/Hkr1 Changes Ciliary Beat Pattern And Biases Cell Steering During Chemotaxis In Chlamydomonas Reinhardtii, Alexis Strain, Nathan Kratzberg, Dan Vu, Emmaline Miller, Ken Ichi Wakabayashi, Adam Melvin, Naohiro Kato Dec 2024

Cop5/Hkr1 Changes Ciliary Beat Pattern And Biases Cell Steering During Chemotaxis In Chlamydomonas Reinhardtii, Alexis Strain, Nathan Kratzberg, Dan Vu, Emmaline Miller, Ken Ichi Wakabayashi, Adam Melvin, Naohiro Kato

Faculty Publications

This study investigates the control of ciliary beat patterns during ammonium chemotaxis in the model ciliate microalga Chlamydomonas reinhardtii. Screening the chemotaxis response of mutant strains with ciliary defects revealed that a strain lacking CAV2, the alpha subunit of the voltage-gated calcium channel, is deficient in ammonium chemotaxis. CAV2 regulates the switching of the ciliary beat pattern from the asymmetric to the symmetric waveform. Strains lacking COP5/HKR1 (chlamyopsin 5/histidine kinase rhodopsin 1) are also deficient in ammonium chemotaxis. Conversely, strains defective in phototaxis perform ammonium chemotaxis normally. Cell motility analysis revealed wild-type cells reduce the incidences of switching the ciliary …

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Creating A Bio-Based Circular Economy From Louisiana Sugarcane Byproducts, G. Aita, D. Bhatnagar, G. O. Bruni, M. Deliberto, G. Eggleston, A. Finger, K. Gravois, M. Isied, W. Judice, K. T. Klasson, I. M. Lima, J. L. Purswell, M. Souliman, E. Terrell, B. S. Tubaña, H. L. Waguespack, J. J. Wang, P. M. White Dec 2024

Creating A Bio-Based Circular Economy From Louisiana Sugarcane Byproducts, G. Aita, D. Bhatnagar, G. O. Bruni, M. Deliberto, G. Eggleston, A. Finger, K. Gravois, M. Isied, W. Judice, K. T. Klasson, I. M. Lima, J. L. Purswell, M. Souliman, E. Terrell, B. S. Tubaña, H. L. Waguespack, J. J. Wang, P. M. White

Faculty Publications

Abstract: Sugarcane (Saccharum officinarum) is Louisiana's number one row crop. Growing and processing sugarcane produces significant amounts of byproducts, including bagasse, crop residue, molasses, filter-press mud, and boiler fly ash. These products represent an important opportunity to generate value-added and specialty products and enhance sugarcane's sustainability by facilitating a circular economy, where agricultural by-products are reused instead of disposing them (linear economy), in order to reduce resource use and energy demand. Examples of value-added products range from biochar, construction materials, animal feed, biofuels, nanoparticles, and fertilizer. Paramount to the success of the bio-based circular economy is creating useful products that …

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Gleaning Rural Journalism: Rural Journalists' Agricultural And Environmental Reporting Utilizing Community Storytelling Networks☆, Jessica Walsh, Mildred F. Perreault, Greg Perreault, Ruth Moon Dec 2024

Gleaning Rural Journalism: Rural Journalists' Agricultural And Environmental Reporting Utilizing Community Storytelling Networks☆, Jessica Walsh, Mildred F. Perreault, Greg Perreault, Ruth Moon

Faculty Publications

Environmental concerns are growing in parts of the rural United States as drinking water wells become contaminated with agrichemicals, and climate change impacts such as drought and extreme rain events disrupt farming practices. Analyzing in-depth interviews with 29 U.S. rural journalists, we explore the role rural journalists play when reporting on the environment as it relates to agricultural issues. Findings show that reporting about the environment—such as weather, climate change, water shortages, and droughts—appear in rural journalists' stories given those topics' relevance to their rural communities and the social systems forces exerting influence on journalists, yet rural journalists often do …

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International Pcos Guideline Clinical Research Priorities Roadmap: A Co-Designed Approach Aligned With End-User Priorities In A Neglected Women's Health Condition, H. J. Teede, M. Gibson, J. Laven, A. Dokras, L. J. Moran, T. Piltonin, M. Costello, A. Mousa, A. E. Joham, C. T. Tay, Wiebke Arlt, Ricardo Azziz, Adam Balen, Lisa Bedson, Lorna Berry, Jacky Boivin, Jacqueline Boyle, Leah Brennan, Wendy Brown, Tania Burgert, Maureen Busby, Carolyn Ee, Rhonda M. Garad, Cheryce Harrison, Roger Hart, Marie Misso, Rachel Morman, Angelica Lindén Hirschberg, Tuong Ho, Kathleen Hoeger, Sonia Jitpiriyaroj, Cailin Jordan, Richard S. Legro, Rong Li Dec 2024

International Pcos Guideline Clinical Research Priorities Roadmap: A Co-Designed Approach Aligned With End-User Priorities In A Neglected Women's Health Condition, H. J. Teede, M. Gibson, J. Laven, A. Dokras, L. J. Moran, T. Piltonin, M. Costello, A. Mousa, A. E. Joham, C. T. Tay, Wiebke Arlt, Ricardo Azziz, Adam Balen, Lisa Bedson, Lorna Berry, Jacky Boivin, Jacqueline Boyle, Leah Brennan, Wendy Brown, Tania Burgert, Maureen Busby, Carolyn Ee, Rhonda M. Garad, Cheryce Harrison, Roger Hart, Marie Misso, Rachel Morman, Angelica Lindén Hirschberg, Tuong Ho, Kathleen Hoeger, Sonia Jitpiriyaroj, Cailin Jordan, Richard S. Legro, Rong Li

Clinical Research Faculty Publications

Background: Polycystic ovary syndrome (PCOS) is a common endocrinopathy with significant reproductive, metabolic, and psychological complications. Consensus on PCOS clinical research priorities across end-users is fundamental and necessitates a robust co-development of a clinical research roadmap to guide international research efforts. Methods: A multistage process included: i) international surveys of women and healthcare providers to identify research priorities and unmet needs; ii) interrogation of systematic reviews conducted for the International PCOS Guideline to identify research gaps; iii) International PCOS Guideline Network consensus generated clinical research roadmap; and iv) international peer review for external validation. Findings: A codesigned survey engaging 1278 …

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Investigating The Role That Calcium And The Membrane Play In 8r-Lipoxygenase Catalysis, Kaelie Bernard Dec 2024

Investigating The Role That Calcium And The Membrane Play In 8r-Lipoxygenase Catalysis, Kaelie Bernard

Honors Capstones

No abstract provided.

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Beyond Surrealism: The Developing Keyboard Style Of André Souris, Melanie T. Mallard Nov 2024

Beyond Surrealism: The Developing Keyboard Style Of André Souris, Melanie T. Mallard

LSU Doctoral Dissertations

André Souris (1899-1970) is perhaps best known as a musical contributor to the Belgian surrealist group founded by Paul Nougé, but he assumed many roles throughout his life, including composer, writer, director, and promoter of modern music. His various interests influenced the style of his compositions, which remain largely unpublished and have received little scholarly attention beyond researchers of surrealism. Through this survey of many of Souris’ works for keyboard, I attempt to lay the groundwork for further discussion about Souris’ musical contributions not only through the lens of surrealism but also throughout his compositional career. This descriptive analysis of …

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Metabolic Scaling, Energy Allocation Tradeoffs, And The Evolution Of Humans’ Unique Metabolism, Andrew K. Yegian, Steven B. Heymsfield, Eric R. Castillo, Manfred J. Müller, Leanne M. Redman, Daniel E. Lieberman Nov 2024

Metabolic Scaling, Energy Allocation Tradeoffs, And The Evolution Of Humans’ Unique Metabolism, Andrew K. Yegian, Steven B. Heymsfield, Eric R. Castillo, Manfred J. Müller, Leanne M. Redman, Daniel E. Lieberman

Clinical Research Faculty Publications

All organisms use limited energy to grow, survive, and reproduce, necessitating energy allocation tradeoffs, but there is debate over how selection impacted metabolic budgets and tradeoffs in primates, including humans. Here, we develop a method to compare metabolic rates as quotients of observed relative to expected values for mammals corrected for size, body composition, environmental temperature, and phylogenetic relatedness. Contrary to previous analyses, these quotients reveal that nonhuman primates have total metabolic rates expected for similar-sized mammals in similar environments. In addition, data from several small-scale societies show that humans evolved exceptionally high resting, activity, and total metabolic rates apparently …

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Safeguarding Ecological Knowledge From The Effects Of Climate Change: An Archival Approach, Daena Jean Carrillo Nov 2024

Safeguarding Ecological Knowledge From The Effects Of Climate Change: An Archival Approach, Daena Jean Carrillo

LSU Doctoral Dissertations

Creating resources that facilitate the preservation of community-based archives and ecological knowledge in the Louisiana coastal region is integral to its survival amongst the effects of climate change. Research and records created and stored within the Louisiana coastal region have a higher predisposition to the drastic and pervasive effects of climate change and natural disasters. Modern archivists can insert themselves into the work of climate change action through their advocacy of safeguarding collections that have been created by communities and individuals through raw scientific and observational data and unpublished research. Just as archivists continue to frame their professional work around …

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Development And Comparative Assessment Of Rt-Qpcr And Duplex Rt-Lamp Assays For The Monitoring Of Aichi Virus A (Aiv-A) In Untreated Wastewater Samples, Mariah C.A. Do Nascimento, Wendy J.M. Smith, Yawen Liu, Stuart L. Simpson, Aaron Bivins, Paula Rahal, Warish Ahmed Nov 2024

Development And Comparative Assessment Of Rt-Qpcr And Duplex Rt-Lamp Assays For The Monitoring Of Aichi Virus A (Aiv-A) In Untreated Wastewater Samples, Mariah C.A. Do Nascimento, Wendy J.M. Smith, Yawen Liu, Stuart L. Simpson, Aaron Bivins, Paula Rahal, Warish Ahmed

Faculty Publications

Diverse enteric pathogens, transmitted through human and animal feces, can cause gastroenteritis. Enteric viruses, such as human Aichi virus, specifically genotype A (AiV-A), are emerging pathogens that cause illnesses even at low doses and are spreading globally. This research developed a reverse transcription quantitative polymerase chain reaction (RT-qPCR) assay targeting the 3CD junction and a reverse transcription colorimetric loop-mediated isothermal amplification (RT-cLAMP) duplex assay targeting junctions 2BC and 3CD of the AiV-A genome for rapid and sensitive detection of this virus in metropolitan and regional wastewater samples in Queensland, Australia. The performance of these assays was evaluated using control materials …

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Gastrointestinal Ischemia In The Horse: Preoperative Detection And Surgical Intervention, Michael P. St. Blanc Nov 2024

Gastrointestinal Ischemia In The Horse: Preoperative Detection And Surgical Intervention, Michael P. St. Blanc

LSU Master's Theses

The objective of this study was to evaluate the utility of calprotectin, a protein released by activated leukocytes during inflammation, in the detection of gastrointestinal ischemia in horses with signs of abdominal pain (colic). Additionally, one-layer end-to-end anastomoses of the descending colon were critically evaluated in comparison to two-layer closures. For the calprotectin portion of the study, samples were obtained from ten control horses and nineteen clinical cases assigned to three treatment groups (non-strangulating, strangulating small intestinal, or strangulating large intestinal lesions). Objective data was collected from each patient, and calprotectin concentration in serum and peritoneal fluid was determined using …

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Mobilizing The Masks Of Carnaval For A Re-Reading Of Zobel's Rue Cases-Nègres, Benjamin E. Tilson Nov 2024

Mobilizing The Masks Of Carnaval For A Re-Reading Of Zobel's Rue Cases-Nègres, Benjamin E. Tilson

Tête à Tête: Journal of Francophone Studies

The identity of Caribbean literature, subject to the forces of domination and exclusion, has long been contested from both within and outside of its field. Alternately described as imitating, reappropriating, indigenizing and reductionist, Caribbean writers have sought to carve out a space for works that are received as authentic without recourse to fetishes. Drawing upon the works of Maryse Condé, the Creolists and anthropologic studies of Carnaval, the present work attempts to analyze what might be termed alternative narratives, characters and symbols in Joseph Zobel’s novel La Rue Cases-Nègres and its filmic adaptation by Euzhan Palcy through the lens of …

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De La Saleté A La Poésie : Portrait De La France Périphérique Dans L’Été Des Charognes De Simon Johannin, Julie Catel Nov 2024

De La Saleté A La Poésie : Portrait De La France Périphérique Dans L’Été Des Charognes De Simon Johannin, Julie Catel

Tête à Tête: Journal of Francophone Studies

Simon Johannin's debut novel, "L'Été des charognes," published in 2017, offers a vivid portrayal of life in La Fourrière, an isolated village located in the Vosges. This area falls within what the French sociologist Christophe Guilluy terms 'France périphérique,' which refers to rural regions plagued by poverty and a sense of neglect. Through the perspective of an adolescent narrator, Johannin depicts the village's harsh daily reality, emphasizing its pervasive violence and the filth that characterizes its landscape. The narrative is saturated with descriptions of unpleasant odors, particularly from the decomposing carcasses of farm animals awaiting disposal, which permeate the village …

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Pooled Analysis Of Physical Activity, Sedentary Behavior, And Sleep Among Children From 33 Countries, Kar Hau Chong, Thomas Suesse, Penny L. Cross, Sarah T. Ryan, Eivind Aadland, Oluwayomi Aoko, Ankhmaa Byambaa, Valerie Carson, Jean Philippe Chaput, Hayley Christian, Dylan P. Cliff, Marieke De Craemer, Clarice Maria De Lucena Martins, Christine Delisle Nyström, Catherine E. Draper, Asmaa El Hamdouchi, Alex Antonio Florindo, Hongyan Guan, Amy S. Ha, Najmeh Hamzavi Zarghani, Kylie D. Hesketh, Mohammad Sorowar Hossain, Jajat Jajat, Thanh Kim, Denise Koh, Anna V. Kontsevaya, Nicholas Kuzik, Marja H. Leppänen, Marie Löf, Himangi Lubree, Kim Meredith-Jones, Tawonga W. Mwase-Vuma, Johan Y.Y. Ng, Rachel Novotny Nov 2024

Pooled Analysis Of Physical Activity, Sedentary Behavior, And Sleep Among Children From 33 Countries, Kar Hau Chong, Thomas Suesse, Penny L. Cross, Sarah T. Ryan, Eivind Aadland, Oluwayomi Aoko, Ankhmaa Byambaa, Valerie Carson, Jean Philippe Chaput, Hayley Christian, Dylan P. Cliff, Marieke De Craemer, Clarice Maria De Lucena Martins, Christine Delisle Nyström, Catherine E. Draper, Asmaa El Hamdouchi, Alex Antonio Florindo, Hongyan Guan, Amy S. Ha, Najmeh Hamzavi Zarghani, Kylie D. Hesketh, Mohammad Sorowar Hossain, Jajat Jajat, Thanh Kim, Denise Koh, Anna V. Kontsevaya, Nicholas Kuzik, Marja H. Leppänen, Marie Löf, Himangi Lubree, Kim Meredith-Jones, Tawonga W. Mwase-Vuma, Johan Y.Y. Ng, Rachel Novotny

Population and Public Health Science Faculty Publications

Importance: The prevalence estimates of physical activity, sedentary behavior, and sleep (collectively known as movement behaviors) in 3-and 4-year-old children worldwide remains uncertain. Objective: To report the proportion of 3-and 4-year-old children who met the World Health Organization guidelines for physical activity, sedentary behavior, and sleep across 33 countries. Design, Setting, and Participants: Pooled analysis of data from 14 cross-sectional studies (July 2008 to September 2022) identified through systematic reviews and personal networks. Thirty-Three countries of varying income levels across 6 geographical regions. Each study site needed to have at least 40 children aged 3.0 to 4.9 years with valid …

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Euphemism In Ai Discourse As Colonial Harm & Effect: Learnings From Subaltern Puerto Rico, Jacqueline Oquendo Nov 2024

Euphemism In Ai Discourse As Colonial Harm & Effect: Learnings From Subaltern Puerto Rico, Jacqueline Oquendo

LSU Doctoral Dissertations

Through three integrated studies, this dissertation explores complex human-AI interactions by comparing the perceptions of two groups of U.S. citizens: subaltern Puerto Ricans and stateside Americans’ interactions with ChatGPT. This corpus-assisted Critical Discourse Analysis or CLCDA, triangulated with 1:1 semi-structured interviews, validates scholars’ concerns about the biases inherent in generative AI. Contributing to those concerns, this dissertation reveals that ChatGPT deploys discourse strategies that, when executed, facilitate digital colonialism. Euphemistic language is prominent among its discourse strategies, replacing controversial words, phrases, and topics with more palatable ones. When prompted on events of historical significance, I find that ChatGPT’s discourse obscures …

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Body, Mind, And Archives: A Critical Questioning Of “Places For Knowledge” In David Treuer’S The Translation Of Dr. Apelles, Lisa Brau-Weglinski Nov 2024

Body, Mind, And Archives: A Critical Questioning Of “Places For Knowledge” In David Treuer’S The Translation Of Dr. Apelles, Lisa Brau-Weglinski

Comparative Woman

Western conceptualizations of time and space are common topics to be queried within the field of Indigenous literary study. However, while the focus has been laid on temporal and spatial literary conventions, too little attention has been drawn to the conceptualization and norms around an identity forming element: knowledge. This paper is particularly suspicious of Western conceptualizations of “places for knowledge,” as this has very real consequences for how we understand and treat ourselves and others. As such, my work highlights that “places for knowledge” can cloud and limit our perception of reality, which, concerning the project of decolonization …

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Mapping Gender And Territory: The Continent Allegories On European World Maps From The Late Middle Ages To The Renaissance Until The Early Enlightenment, Katharina Eva Oehmichen Nov 2024

Mapping Gender And Territory: The Continent Allegories On European World Maps From The Late Middle Ages To The Renaissance Until The Early Enlightenment, Katharina Eva Oehmichen

Comparative Woman

The four-part set of female continent allegories, which originated in the early Renaissance, was born out of a European need for a new vehicle of thought that served the functions of representing imperial expansion and the superiority of Western science and civilization, while gratifying the curiosity of the readers about newly discovered lands at the same time. The shift from the Christian symbolic tradition of the representation of the continents on world maps mirrored the shift in Western perception and knowledge of the world and Europe’s position in it. Apart from geo-political and imperial agendas that might have favored a …

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