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Mysteerio: Multi-Regional Environmentally Extended Input-Output Model For United States, Yash Srivastava

All Theses

This research work titled My State Environmentally Extended Regional Input-Output (MYSTEERIO) is based on the concept of multi-regional environmentally extended input-output (MREEIO), which is a combination of lifecycle thinking and economics principles. Numerous studies have highlighted the advantages of using this methodology to determine the environmental impacts associated with economic activities for a region. However, no prior attempt has been made to conduct a state-level analysis for the US. This research work thus tries to estimate the impacts embodied due to the consumption of goods and services at the state level by using the MREEIO principles. Extensive coverage of the …

Oam-Based Wavelets In A High Speed Optical Probing System For Measuring The Angular Decomposition Of The Environment, Justin Free

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This thesis presents the theoretical development of orbital angular momentum (OAM) based wavelets for the analysis of localized OAM information in space. An optical probing system for generating and detecting these wavelets is demonstrated; individual wavelets can scan the environment in 10µs or less. The probing system was applied to a three-dimensional atmospheric turbulence distribution to obtain a continuous wavelet transform of the angular information of the turbulent propagation path about a fixed radius. An entire continuous wavelet transform was measured in 3.8ms; the measurements are much faster than the turbulence and give insight into the short time scale of …

Iron Phosphate Glass For The Immobilization Of Dehalogenated Salt Waste, Matthew Aaron Page

All Theses

Electrochemical reprocessing can be used to recycle presently stored nuclear fuel and consists of dissolving that used fuel in molten salt and the waste produced from these processes is a small amount of a high-level salt waste. Vitrification has been selected as the primary means of safely disposing high and low level radioactive waste. This is due to glass’ ability to incorporate many elements within its matrix, and it is chemically durable with the addition of network formers and other glass forming chemicals. With over 90,000 tonnes of nuclear waste in the United States, the avoidance of additional steps required …

An Application Of Optimized Bistable Laminates As A Low Velocity, Low Impact Mechanical Deterrent, Graham Lancaster

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This research considers the problem of using bistable laminates as a mechanical deterrent to the impending impact of a particle. The structure will be controlled through an algorithm that will utilize piezoelectric devices to activate them in unison with the bistable laminate to successfully deter. A novel experimental setup will be constructed to ensure that the bistable laminate stays fixed when acting as a mechanical deterrent. Piezoelectricity is the main driving force of the bistable laminate to morph and this study will use a Macro Fiber Composite (MFC) actuator that contains piezoelectric ceramic rods in a patch to transfer electrical …

Scalable Data-Driven Predictive Modeling And Analytics For Cho Process Development Optimization, Sarah Mbiki

All Dissertations

In 1982, the FDA approved the first recombinant therapeutic protein, and since then, the biopharmaceutical industry has continued to develop innovative and highly effective biological drugs for various illnesses¹. These drugs are produced using host organisms that are modified to hold the genetic encoding of the targeted protein¹. Of the many host organisms, Chinese hamster ovary (CHO) cells are often used due to capability to perform posttranslational modification (PTM): which allows human-like synthesis of proteins unlikely to invoke immunogenicity in humans ^1,2.

Despite all the positive attributes, many challenges are associated with CHO cell cultures, …

Combining Network Modeling And Experimental Approaches To Predict Drug Combination Responses, Deepraj Sarmah

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Cancer is a lethal disease and complex at multiple levels of cell biology. Despite many advances in treatments, many patients do not respond to therapy. This is owing to the complexity of cancer-genetic variability due to mutations, the multi-variate biochemical networks within which drug targets reside and existence and plasticity of multiple cell states. It is generally understood that a combination of drugs is a way to address the multi-faceted drivers of cancer and drug resistance. However, the sheer number of testable combinations and challenges in matching patients to appropriate combination treatments are major issues.

Here, we first present a …

Fabrication And Characterization Of Polymer Blends Containing Plant Oil-Derived Copolymers, Najah Mhesn

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Growing environmental concerns associated with the production and disposal of traditional plastics, the depletion of non-renewable fossil resources, as well as pollution of landfills and the oceans have motivated researchers to pursue alternatives to petroleum-based materials. To this end, this research aims to develop environmentally friendly alternatives to petroleum-based plastics, thereby reducing the dependence on non-renewable resources. Namely, we report on the fabrication and characterization of polymer blends consisting of copolymers derived from soybean oil (as a minor phase) and matrix made from commercially available polymers: Polystyrene (PS) and Poly(lactic acid) (PLA). The copolymers employed in this work were obtained …

Development Of A Tissue Engineered Cardiac Patch, Howard Herbert

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Cardiovascular Disease(CVD) is the leading cause of mortality in the developed world. CVD is most commonly manifested as atherosclerosis of the coronary arteries leading to Myocardial Infarction(MI). After MI, fibrosis of the ventricular wall leads to heart failure(HF), a pandemic affecting 26 million people globally. While therapies are continuously developed to combat HF, the treatment of choice, whole heart transplant, is limited by the availability of donor hearts. It is clear that there is a need to develop a long-term solution to combat HF and its enormous economic burden. Tissue Engineering and Regenerative Medicine holds promise as a possible solution …

Family Diabetes Camp Amidst Covid-19: A Community Of Practice Model, Eddie Hill, Rowan Halle Bernard Williams, Justin A. Haegele, Ron Ramsing, Bethany Arrington, Laura Hill

Journal of Youth Development

Studies have found that youth are experiencing higher anxiety levels than prior to COVID-19, and youth with type 1 diabetes are at higher risk. Medical specialty camps are a type of camp that provide opportunities for youth with chronic illnesses to share common goals, increase socialization, improve camper well-being, and increase knowledge of diabetes management. The program evaluation sought to determine the impact of a campers’ outcomes of independence and perceived competence and familial impact during COVID-19. Over half the participants were at their first diabetes camp and 71% of the campers felt their perceived competence “increased a little bit” …

The Importance Of Hand Motions For Communication And Interaction In Virtual Reality, Alex Adkins

All Dissertations

Virtual reality (VR) is a growing method of communication and play. Recent advances have enabled hand-tracking technologies for consumer VR headsets, allowing virtual hands to mimic a user's real hand movements in real-time. A growing number of users now utilize hand-tracking when using VR to manipulate objects or to create gestures when interacting with others. As VR grows as a tool and communication platform, it is important to understand how the rising prevalence of hand-tracking technology might affect users' experiences.

The goal of this dissertation is to investigate, through a series of experiments, how using hand motions in VR influences …

High-Performance Vlsi Architectures For Lattice-Based Cryptography, Weihang Tan

All Dissertations

Lattice-based cryptography is a cryptographic primitive built upon the hard problems on point lattices. Cryptosystems relying on lattice-based cryptography have attracted huge attention in the last decade since they have post-quantum-resistant security and the remarkable construction of the algorithm. In particular, homomorphic encryption (HE) and post-quantum cryptography (PQC) are the two main applications of lattice-based cryptography. Meanwhile, the efficient hardware implementations for these advanced cryptography schemes are demanding to achieve a high-performance implementation.

This dissertation aims to investigate the novel and high-performance very large-scale integration (VLSI) architectures for lattice-based cryptography, including the HE and PQC schemes. This dissertation first presents …

Measurement And Evaluation Of Roadway Geometry For Safety Analyses And Pavement Material Volume Estimation For Resurfacing And Rehabilitation Using Mobile Lidar And Imagery-Based Point Clouds, Leonildo Nelson Cassule

All Dissertations

Roadway safety is a multifaceted issue affected by several variables including geometric design features of the roadway, weather conditions, sight distance issues, user behavior, and pavement surface condition. In recent years, transportation agencies have demonstrated a growing interest in utilizing Light Detecting and Ranging (LiDAR) and other remote sensing technologies to enhance data collection productivity, safety, and facilitate the development of strategies to maintain and improve existing roadway infrastructure. Studies have shown that three-dimensional (3D) point clouds acquired using mobile LiDAR systems are highly accurate, dense, and have numerous applications in transportation. Point cloud data applications include extraction of roadway …

Behavioral Ecology Of The American Alligator (Alligator Mississippiensis) In Human-Dominated Landscapes Of Coastal South Carolina, Anjelika Kidd-Weaver

All Dissertations

When wildlife habitat is developed to accommodate growing human populations, wildlife are forced to move to undisturbed landscapes or to acclimate to a novel, anthropogenic environment. In this dissertation, we investigated the behavior and ecology of the American alligator (Alligator mississippiensis) in coastal, residential resort communities with an overarching goal of identifying behavioral patterns of alligators that can inform risk management strategies. In Chapter One, we compared the space use of male and female alligators in primarily wetland versus residential landscapes across three seasons to determine if and how space use behaviors of alligators differ. We found that …

Highly Adherent Antimicrobial Coatings For Orthopedic Implants, Mikhail Bredikhin

All Dissertations

Fracture-related infections (FRIs) are the most devasting sort of complications associated with fracture fixation devices, as they lead to patients’ morbidity, prolonged hospitalization, amputations, and even death.External fixators additionally suffer from pin site infections (PSIs), which initiate at the skin entry points of the skin-metallic pin interface present in the external fixation of the damaged bones, often causing deep tissue infection and osteomyelitis. Small percutaneous pins, commonly known as Kirschner wires (K-wires), are used to treat complex fractures and deformities.They are drilled inside the diseased bone for the healing period and are left protruding outside the skin for fixation adjustments …

Likeliness To Recommend: A Mixed Methods Analysis Of Consumer Perception Of Homebuilders, Todd Usher

All Dissertations

Measures of consumers’ likeliness to recommend a business or company have been shown to relate to business performance. Less is known about how such scores might operate in the homebuilding industry. This study examines the factors influencing consumers’ perceptions of homebuilders, an area with little published research. Using a sequential mixed-methods approach, the study analyzes survey data from consumers (N = 366) who had new homes built within the preceding 12 months. Quantitative analyses of the data reveal several aspects of consumers’ likeliness to recommend a homebuilder. One finding of great interest is that consumers of the survey were more …

Essays On Perioperative Services Problems In Healthcare, Amogh S. Bhosekar

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One of the critical challenges in healthcare operations management is to efficiently utilize the expensive resources needed while maintaining the quality of care provided. Simulation and optimization methods can be effectively used to provide better healthcare services. This can be achieved by developing models to minimize patient waiting times, minimize healthcare supply chain and logistics costs, and maximize access. In this proposal, we study some of the important problems in healthcare operations management. More specifically, we focus on perioperative services and study scheduling of operating rooms (ORs) and management of necessary resources such as staff, equipment, and surgical instruments. We …

On Variants Of Sliding And Frank-Wolfe Type Methods And Their Applications In Video Co-Localization, Seyed Hamid Nazari

All Dissertations

In this dissertation, our main focus is to design and analyze first-order methods for computing approximate solutions to convex, smooth optimization problems over certain feasible sets. Specifically, our goal in this dissertation is to explore some variants of sliding and Frank-Wolfe (FW) type algorithms, analyze their convergence complexity, and examine their performance in numerical experiments. We achieve three accomplishments in our research results throughout this dissertation. First, we incorporate a linesearch technique to a well-known projection-free sliding algorithm, namely the conditional gradient sliding (CGS) method. Our proposed algorithm, called the conditional gradient sliding with linesearch (CGSls), does not require the …

Enhancing The Performance Of Poly(3-Hexylthiophene) Based Organic Thin-Film Transistors Using An Interface Engineering Method, Eyob Negussie Tarekegn

All Dissertations

An original design and photolithographic fabrication process for poly(3-hexylthiophene-2, 5-diyl) (P3HT) based organic thin-film transistors (OTFTs) is presented. The structure of the transistors was based on the bottom gate bottom contact OTFT. The fabrication process was efficient, cost-effective, and relatively straightforward to implement. Current–voltage (I-V) measurements were performed to characterize the primary electronic properties of the transistors. The measured mobility of these transistors was significantly higher than most results reported in the literature for other similar bottom gate bottom contact P3HT OTFTs. The higher mobility is explained primarily by the effectiveness of the fabrication process in keeping the interfacial layers …

Permanently-Installed Distributed Pressure Sensors For Downhole Applications, Xuran Zhu

All Dissertations

Technology advancements (e.g., hydraulic fracturing and horizontal drilling) to recover unconventional oil and gas (UOG) resources are critical in maintaining future U.S. oil and gas production levels. Permanently installed distributed downhole pressure sensors could monitor fracture propagation, assess the effectiveness of hydraulic fracturing, and optimize hydraulic fracturing placement so that overall UOG recovery efficiency can be increased. However, the harsh environment (high temperatures, high pressures, strong vibration, and presence of brine, mud, debris, hydrate, and various gases), the long data telemetry distance, and the requirements of reliability and service lifetime make the downhole monitoring a very challenging task. To combat …

Metabolic Engineering Of Yarrowia Lipolytica For Enhanced Peroxisomal Production Of Polyhydroxyalkanoates, Michael Spagnuolo

All Dissertations

Traditional chemical processes are made inefficient by the generation of side products and reactions that fail to reach completion. Bioprocesses, on the other hand, lose product potential due to the necessity of growing the organism required to produce the desired compounds. The field of metabolic engineering often seeks to alter this balance between product formation and cell growth to generate more product from the same quantity of feed (reagent). In addition to balance, such organisms may also be engineered to produce the desired products from nontraditional substrates, such as waste compounds. In resource-poor environments, the ability to produce a wanted …

Ligand-Promoted Dissolution Of Uranyl Phosphate Across Scales, Brennan Ferguson

All Dissertations

The formation of uranyl phosphate precipitate is a remediation strategy because the low solubility of uranyl phosphate minerals, like chernikovite, limits the mobility of uranium in contaminated soils. However, organic ligands can complex with aqueous metal cations to form more soluble species. For example, citrate is a commonly occurring organic ligand produced by plants and microbes that increases the solubility of uranium and therefore the dissolution of uranyl phosphate minerals in the uranyl phosphate-citrate system. This effect is an important control on the mobility of uranium in organic-rich, and near-surface vegetated environments. Nevertheless, key aspects of the citrate-uranyl phosphate system …

Mechanics Modeling Of Non-Rigid Origami: From Qualitative To Quantitative Accuracy, Jiayue Tao

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Origami, the ancient art of paper folding, has recently evolved into a design and fabrication framework for various engineering systems at vastly different scales: from large-scale deployable airframes to mesoscale biomedical devices to small-scale DNA machines. The increasingly diverse applications of origami require a better understanding of the fundamental mechanics and dynamics induced by folding. Therefore, formulating a high-fidelity simulation model for origami is crucial, especially when large amplitude deformation/rotation exists during folding.

The currently available origami simulation models can be categorized into three branches: rigid-facet models, bar-hinge models, and finite element models. The first branch of models assumes that …

Multi-Criteria Performance Evaluation And Control In Power And Energy Systems, Payam Ramezani Badr

All Dissertations

The role of intuition and human preferences are often overlooked in autonomous control of power and energy systems. However, the growing operational diversity of many systems such as microgrids, electric/hybrid-electric vehicles and maritime vessels has created a need for more flexible control and optimization methods. In order to develop such flexible control methods, the role of human decision makers and their desired performance metrics must be studied in power and energy systems. This dissertation investigates the concept of multi-criteria decision making as a gateway to integrate human decision makers and their opinions into complex mathematical control laws. There are two …

Quantifying And Identifying Mechanisms Of Resistance To Thrips (Thysanoptera: Thripidae) In Landraces Of Upland Cotton (Gossypium Hirsutum), Sophia Christian

All Dissertations

Throughout the southeastern USA, tobacco thrips (Frankliniella fusca Hinds) are the primary thrips (Thysanoptera: Thripidae) pest species of cotton (Gossypium spp.) seedlings and are often detrimental to the establishing crop. In 2020, cotton yield losses from thrips and their management cost USA growers $70.7 million. Heavy reliance on prophylactic insecticides, primarily used as seed treatments, has led to insecticide-resistant populations of tobacco thrips. Currently, no known commercial cotton cultivar provides protection to prevent injury from thrips feeding. A sustainable, alternative management tactic is needed to address insecticide-resistant populations of and reduce damage from thrips in cotton. Our research evaluated day-neutral, …

Infusing Kirigami Principles Into Design Of Mechanical Properties, Hesameddin Khosravi

All Dissertations

The emergence of mechanical metamaterials — which derive their properties primarily from the underlying architecture rather than the constituent material — has unleashed a new era of material design and functionalities. To fully materialize the promising potentials of metamaterials, it is crucial to develop versatile, scalable, and easy-to-fabricate methods that can both generate and tailor the underlying periodic architecture. To this end, we propose the use of kirigami — a popular recreational art of cutting and manipulating paper — as a platform to create periodicity and super-stretchability. Kirigami has become a design and fabrication framework for constructing metamaterials, robotic tools, …

Modeling, Control And Estimation Of Reconfigurable Cable Driven Parallel Robots, Adhiti Raman Thothathri

All Dissertations

The motivation for this thesis was to develop a cable-driven parallel robot (CDPR) as part of a two-part robotic device for concrete 3D printing. This research addresses specific research questions in this domain, chiefly, to present advantages offered by the addition of kinematic redundancies to CDPRs. Due to the natural actuation redundancy present in a fully constrained CDPR, the addition of internal mobility offers complex challenges in modeling and control that are not often encountered in literature.

This work presents a systematic analysis of modeling such kinematic redundancies through the application of reciprocal screw theory (RST) and Lie algebra while …

Large Genomes Assembly Using Mapreduce Framework, Yuehua Zhang

All Dissertations

Knowing the genome sequence of an organism is the essential step toward understanding its genomic and genetic characteristics. Currently, whole genome shotgun (WGS) sequencing is the most widely used genome sequencing technique to determine the entire DNA sequence of an organism. Recent advances in next-generation sequencing (NGS) techniques have enabled biologists to generate large DNA sequences in a high-throughput and low-cost way. However, the assembly of NGS reads faces significant challenges due to short reads and an enormously high volume of data. Despite recent progress in genome assembly, current NGS assemblers cannot generate high-quality results or efficiently handle large genomes …

Investigating Spatial Heterogeneity In Myocardial Wound Environments To Improve Therapy, Michael Potter

All Dissertations

Heart failure is a broad pathology manifestation categorized by an inability of the heart to successfully pump blood throughout the vast vessel network of the body. Within the United States, heart failure is projected to increase by approximately 46% from 2012 to 2030. Modalities of heart failure are generally related to wall mechanics that are impacted following myocardial infarction events. Interplay exists between the wall mechanics, responding cell populations, and the spatial heterogeneities in the resultant scar. This interplay directs the myocardium towards heart failure modalities governed by overly stiff or compliant states. It is essential to elucidate details underlying …

The Impact Of Funds Of Knowledge On Elementary Multilingual Learners’ Perceptions Of Their Connection To Their Teacher And The Classroom, Kelli Lowe

All Dissertations

The U.S. population is rapidly becoming more culturally and linguistically diverse, and the education system is ill-equipped to meet the needs of these diverse learners thus creating large achievement gaps. In South Carolina, two factors contributing to an inadequate education system are the lack of teacher preparation programs that address cultural diversity and a predominantly White teacher workforce for an ever-growing diverse student body. The combination of these two factors is particularly detrimental to multilingual learners in the most critical time of a child’s development. This qualitative study was part of a collaboration and combined improvement science with design thinking …

Elucidation Of Active Site And Mechanism Of Metal Catalysts Supported In Nu-1000, Hafeera Shabbir

All Dissertations

Advances in extraction of shale oil and gas has increased the production of geographically stranded natural gas (primarily consisting of methane (C1) and ethane (C2)) that is burned on site. A potential utilization strategy for shale gas is to convert it into fuel range hydrocarbons by catalytic dehydrogenation followed by oligomerization by direct efficient catalysts. This work focuses on understanding metal cation catalysts supported on metal-organic framework (MOF) NU-1000 that will actively and selectively do this transformation under mild reaction conditions, while remaining stable to deactivation (via metal agglomeration or sintering). I built computational models validated by experimental methods to …