Digital Commons Network^™

Methyltransferase, Glucose Adaptation, And Import Complex In Trypanosoma Brucei, Emily Knight

All Dissertations

Trypanosoma brucei is a kinetoplastid parasite responsible for human African trypanosomiasis (HAT) and nagana, a livestock wasting disease, which both endemic to sub-Saharan Africa. Unique to kinetoplastids are the specialized peroxisomes, named glycosomes, which compartmentalize the first several steps of glycolysis and gluconeogenesis, nucleotide sugar biosynthesis, and many other metabolic processes. Kinetoplastids are unique in that they have a single mitochondrion. In this work, I present the first study into SET domain proteins in any kinetoplastid parasites. We have characterized a predicted SET domain protein, TbSETD3, that localizes to the mitochondrion and a depletion of the protein results in growth …

Essays On Labor Market Size And Job Match Quality, Lan Lan

All Dissertations

This dissertation is comprised of two essays that delve into the construction of a major-related labor market and its correlation with college graduates’ job match quality. Investigating the job match quality of college graduates for different majors in large cities is crucial, as it provides evidence on which majors tend to yield better job matches. This contributes to the study of the return on major while also shedding light on how city size impacts individuals’ ability to find jobs that align with their educational level and major, thereby enriching the study of the benefits of agglomeration.

The first chapter examines …

Characterization Of Lignin And Cellulose Biopolymers Structure – Function Relationships, Zachariah Pittman

All Dissertations

Biomass is vital to ongoing efforts to secure a sustainable future. While many of our efforts focus on finding alternative forms of energy, biomass among them, only biomass has the potential to serve as a sustainable materials feedstock. However, biomass is heterogenous, complicating the upgrading processes needed to manufacture commodity and performance products. For example, plant biomass consists largely of cellulose, a crystalline polysaccharide, and lignin, a highly stable polyaromatic. The specific properties of cellulose and lignin depend greatly on the plant, harvesting conditions, and isolation procedures. Thus, accurate and reliable determination of the fundamental properties of biomass is crucial …

Classification Of Electrical Current Used In Electroplastic Forming, Tyler Grimm

All Dissertations

Electrically assisted manufacturing (EAM) is the direct application of an electric current to a workpiece during manufacturing. This advanced manufacturing process has been shown to produce anomalous effects which extend beyond the current state of modeling of thermal influences. These purported non-thermal effects have collectively been termed electroplastic effects (EPEs).

While there is a distinct difference in results between steady-state (ideal DC) testing and pulsed current testing, the very definition of these two EAM methods has not been well established. A "long" pulse may be considered DC current; a "short" pulse may produce electroplastic effects; and even "steady-state" current shapes …

Designing Noncentrosymmetric Multifunctional Materials, Ebube Oyeka

All Dissertations

Noncentrosymmetric (NCS) materials with crystal lattices lacking spatial inversion symmetry display a wide range of exciting functionalities. This dissertation covers two classes of functional NCS materials: magnetic skyrmion-host compounds and multifunctional materials. Magnetic skyrmion and multifunctional materials combining optical and magnetic responses are providing avenues for developing and optimizing the performance of electronic devices that can have uses in memory storage, laser technology, medicine, sensors, etc. The formation of skyrmions is driven by asymmetric Dzyaloshinskii–Moriya (DM) interaction facilitated by broken spatial inversion symmetry and large spin-orbit coupling (SOC), while multiple functionalities arise when spin carriers and optical chromophores are optimally …

Top Down Effects And Resource Selection By Coyotes In South Carolina, Alex Jensen

All Dissertations

Top predators play important roles in functioning ecosystems, including regulating the populations of prey species and competing with other predators. However, in the face of global change, many top terrestrial predators have declined in both range and abundance, making room for some smaller predators to expand into new niches. Coyotes (Canis latrans) in North America are a prime example of this – they have rapidly expanded their range in the last 120 years, raising concerns about their impacts on both domestic and wild species. In eastern North America, research has centered around their effects on white-tailed deer ( …

Advancements In Fluid Simulation Through Enhanced Conservation Schemes, Sean Ingimarson

All Dissertations

To better understand and solve problems involving the natural phenomenon of fluid and air flows, one must understand the Navier-Stokes equations. Branching several different fields including engineering, chemistry, physics, etc., these are among the most important equations in mathematics. However, these equations do not have analytic solutions save for trivial solutions. Hence researchers have striven to make advancements in varieties of numerical models and simulations. With many variations of numerical models of the Navier-Stokes equations, many lose important physical meaningfulness. In particular, many finite element schemes do not conserve energy, momentum, or angular momentum. In this thesis, we will study …

The Search For Heavily Obscured Active Galactic Nuclei In The Local Universe, Ross Silver

All Dissertations

Active galactic nuclei (AGN) are supermassive black holes (SMBHs) in the center of galaxies that accrete surrounding gas and emit across the entire electromagnetic spectrum. They are the most energetic persistent emitters in the Universe, capable of outshining their host galaxies despite their emission originating from a region smaller than our Solar System. AGN were some of the first sources discovered that helped teach us that there were galaxies outside of our own, and they proved the existence of black holes. Moreover, AGN can give us valuable insights into other branches of astrophysics. For example, they can be used to …

Machine Learning-Based Data And Model Driven Bayesian Uncertanity Quantification Of Inverse Problems For Suspended Non-Structural System, Zhiyuan Qin

All Dissertations

Inverse problems involve extracting the internal structure of a physical system from noisy measurement data. In many fields, the Bayesian inference is used to address the ill-conditioned nature of the inverse problem by incorporating prior information through an initial distribution. In the nonparametric Bayesian framework, surrogate models such as Gaussian Processes or Deep Neural Networks are used as flexible and effective probabilistic modeling tools to overcome the high-dimensional curse and reduce computational costs. In practical systems and computer models, uncertainties can be addressed through parameter calibration, sensitivity analysis, and uncertainty quantification, leading to improved reliability and robustness of decision and …

A Value-Based Sequential Optimization Framework For Efficient Materials Design Considering Uncertainty And Variability, Maher Alghalayini

All Dissertations

Many problems in engineering and science can be framed as decision problems in which we choose values for decision variables that lead to desired outcomes. Notable examples include maximizing lift in airplane wing design, improving the efficiency of a power plant, or identifying processing protocols resulting in structural materials with desired mechanical properties. These problems typically involve a significant degree of uncertainty about the often-complex underlying relationships between the decision variables and the outcomes. Solving such decision problems involves the use of computational models or physical experimentation to generate data to make predictions and test hypotheses. As a result, both …

Conceptualizing Technology In Landscape Architecture (Tla) For The 21st Century, Xiwei Shen

All Dissertations

Technology in Landscape Architecture (TLA) has continually expanded from the 19^th century arts-science binary narrative (Beardsley, 2000). However, the current scholarly literature does not appear to acknowledge TLA as core to the discipline of Landscape Architecture (LA) and indicates a knowledge gap. The goal of this qualitative research is to explore TLA and clarify DTT and TLA’s relationship(s) with themes and topics in LA research, and LA core domains. Additionally, the aim is to reveal the meaning of TLA for LA research. This study draws from three realms of knowledge: 1) Digital Tools and Technology (DTT) in LA; 2) …

Fluorescence Multiplexing With Combination Probes For Biological And Diagnostic Applications, Madeline Mccarthy

All Dissertations

Cancer refers to a group of diseases containing more than 200 different subtypes. Cancer is a heterogeneous disease by nature, meaning that there are differences among tumors of the same type in different patients, and there are differences among cancer cells within a single tumor of one patient. Since cancer is not a single disease, nor does it have a single cause, it proves to be incredibly hard to diagnose and treat. The ability to study cellular markers, cell and tissue spatial arrangement, and gene function are all integral parts of cancer diagnostic and treatment efforts.

Here, I first present …

A Multi-Pronged Investigation To Identify Genes Affecting The Autoregulation Of Nodulation: Lasercapture Microdissection And The Barely Any Meristem Gene Family In Medicago Truncatula, Jacklyn Thomas

All Dissertations

The unique evolutionary adaptation of legumes for nitrogen-fixing symbiosis leading to nodulation is tightly regulated by the host plant. One pathway negatively regulates the number of nodules formed in response to the metabolic status of the shoot (carbon) and root (nitrogen); this long-distance systemic regulation is the autoregulation of nodulation (AON) pathway. AON is a root to shoot pathway that allows the plant to limit the number of nodules formed on roots. Central to the receptor complex in the shoots is a leucine-rich-repeat receptor-like kinase (LRR-RLK) called MtSUNN mutation of which results in plants with too many nodules. SUNN …

Clemson Board Of Trustee Minutes, Full Board Minutes, 2023 April 21, Clemson University Board Of Trustees

Minutes

No abstract provided.

Clemson Board Of Trustee Minutes, Compensation Committee, 2023 April 21, Clemson University Board Of Trustees

Minutes

No abstract provided.

Youth Science Learning As/For Community Participation: Examples From Youth Participatory Action Research, Steven M. Worker, Sally Neas, Dorina Espinoza, Car Mun Kok, Martin Smith

Journal of Youth Development

Youth development programs often provide young people with science learning experiences. We argue for reframing youth science learning from a focus on individual scientific literacy to an emphasis on collective scientific literacy—community science—to support young people in using science to address issues in their lives and communities. We provide examples from youth participatory action research (YPAR), one community science pedagogical approach. The YPAR model supports youth in deciding upon an environmental, economic, or social issue; designing and implementing research; and using their research findings to improve their community. We implemented YPAR with eight cohorts of youth over three years at …

The Lasting Benefits Of Multiyear Camp Programming For Youth From Low-Income Backgrounds, Victoria Povilaitis, Robert Warner, Katie Mcgregor Wheatley

Journal of Youth Development

Summer camps are a common youth development setting in North America; however, youth from lowincome backgrounds often cannot attend because of financial barriers. Subsequently, although a robust camp literature exists, little is known about the lasting benefits for youth from low-income backgrounds. Even less is known about how these outcomes may differ based on the number of years youth attend a multi-year camp. The purpose of this study was to examine the long-term outcomes camp alumni reported as attributable to camp and that remain important in their life today. Eighteen outcomes examined via a cross-sectional retrospective survey completed by 449 …

Cultural Insights On The First School Building For Deaf Children In Belleville, Ontario, Canada, 1870-1922, Clifton F. Carbin, Dana J. Fano

Society for American Sign Language Journal

No abstract provided.

Assessing Hardware Security Threats Posed By Hardware Trojans In Power Electronics, Quinn Kinzie

All Theses

This study investigates the threat of hardware Trojans (HTs) in power electronics applications, a rising concern due to the growing demand for cost-effective embedded solutions in power systems. With the supply chain for electronic hardware devices expanding globally, particularly to low-cost foundries in foreign locations, there is an increasing risk of HT attacks. While there has been extensive research on HTs in computer applications, little consideration has been given to their threat in power electronics. This study demonstrates the effectiveness of a power electronics HT by implementing a novel HT design into a gate drive circuit. Additionally, the research proposes …

Clemson Board Of Trustee Minutes, Full Board Minutes, 2023 Februrary 2, Clemson University Board Of Trustees

Minutes

No abstract provided.

Clemson Board Of Trustee Minutes, Educational Policy Committee, 2023 Februrary 2, Clemson University Board Of Trustees

Minutes

No abstract provided.

Clemson Board Of Trustee Minutes, Finance And Facilities Committee, 2023 Februrary 2, Clemson University Board Of Trustees

Minutes

No abstract provided.

2023, Camp Research Forum Book Of Abstracts, American Camp Association

ACA National Camp Research Forum Abstracts

This book includes 19 abstracts that will be presented at the 2023 American Camp Association (ACA) Research Forum to be held during the ACA annual conference from February 21-24, 2023 in Orlando, FL. Abstracts have been grouped into similar areas and will be verbally presented in four sessions.

Crypto Bestiary: A Monstrous Manual To The Many Fraudulent Accounts Involved In Cryptocurrency Scams And Fraud., Patrick Warren, Darren Linvill, Steven Sheffield, Jayson Warren, Leland Fecher, Kate Tesh, Jack Taylor, Malia Fairbanks, Alexa Gubanich, Janna Gubanich, Sarah Meadows, Josephine Rohrer, Adrian Colaianni, Conor Pridnia, Ella Kea, Garret Kent, Kaitlyn Sammons, Phebe Webb, Justin Shay Easler, Josiah Lamont, Katie Batten, Parker Hundley, Molly Sutton

Media Forensics Hub Creative Inquiry Reports

Cryptocurrencies have fueled the growth of online fraud in various forms. They are poorly understood by many users, have value that shifts quickly and unexpectedly, and are easy to move in a digital world without borders. Cryptocurrency is seemingly purpose built as a tool for hucksters and scammers. The Federal Trade Commission claims that 46,000 people reported losing over a billion dollars in cryptocurrency to scammers in the first six months of 2021,1 a figure only including those potentially few people have been brave enough to share that they have been victims. The world of cryptocurrency can be scary for …

Common Data Set 2022-2023, Clemson University

Common Data Sets

No abstract provided.

Introduction To The Special Issue On Immunology, Colby Tofel-Grehl, Brooke A. Whitworth

Publications

The COVID-19 pandemic laid bare the absence of needed resources for teachers to engage students in learning about infectious disease as both a socioscientific issue and a scientific phenomenon (Kafai et al. 2022). With infectious disease largely absent from the NGSS, teachers had to creatively link lessons that contextualized and examined key aspects of infectious disease education during the COVID-19 pandemic. We saw in real time the impacts of popular news, social media, and public mood on broader socioscientific behaviors such as vaccination, masking, and social distancing. We watched as people’s understanding of the nature of science (Lederman 2013) …

Shooting For Equity: Division Ii Basketball Coaches' Perspectives Of Gender Discrimination, Caroline George Fletcher, Sarah Stokowski, Michael S. Carroll, Jonathan E. Westfall

Publications

No abstract provided.

Clemson Commencement Program, December 2022, Clemson University

Clemson Commencement Programs

No abstract provided.

Microcosm Evaluation Of Natural And Biologically-Enhanced Abiotic Transformation Of Chlorinated Ethenes In Low Permeability Formations, Hao Wang

All Dissertations

Trichloroethene (TCE) is one of the most commonly found hazardous compounds at Superfund sites, especially in groundwater. Its volatility and toxicity pose a threat to drinking water safety and human health. In the past decades, research on the fate of TCE in the environment has shifted to contamination of low-permeability formations, for example fractured bedrock aquifers. TCE back-diffusion from low permeability zones and management of persistent TCE groundwater plumes caused by this long-term source zone pose major challenges for remediation.

Monitored natural attenuation (MNA) is a cost-effective remediation strategy that has gradually gained acceptance by regulators. Compared to extensive active …

The Role Of Vsmc Mir-33a Expression On Apoa-I Mediated Cholesterol Efflux And Macrophage-Like Cell Transdifferentiation, Ikechukwu Esobi

All Dissertations

Atherosclerosis is a condition caused by cholesterol accumulating in arterial intimal cells and is a disease that kills more people in the United States and globally than any other disease. Atherosclerosis is commonly recognized to arise from arterial intimal macrophage cholesterol accumulation, but cell lineage tracing technology has shown that a large majority of cholesterol-laden intimal cells found in atherosclerotic arteries are actually vascular smooth muscle cells that have switched phenotypes to a macrophage-like cell. This vascular smooth muscle cell to macrophage-like cell phenotypic switch is known as transdifferentiation and can be triggered by vascular smooth muscle cell cholesterol accumulation. …