Digital Commons Network^™

An Overview Of Risk Factors For Neural Tube Defects And An Investigation Within South Carolina, Lucy Pulliam

All Dissertations

Neural tube defects (NTDs) are congenital anomalies that affect both the morbidity and mortality of infants worldwide. Inadequate levels of the vitamin folate in women during early pregnancy have been shown to be a risk factor for NTDs. Recent efforts to ensure adequate folate intake in mothers have been helpful in reducing but not eliminating NTDs. This dissertation examines additional risk factors for NTDs as possible focus areas for decreasing NTD occurrence.

Chapter Two and Chapter Three are literature reviews conducted to explore select factors associated with an increased risk of NTDs and how these factors may affect folate availability …

Salinity In Propagation: Germination And Juvenile Acclimatization Of Wetland Halophytes Using Saline Irrigation, Morgan Tomlin

All Theses

The introduction of poor water quality into commercial nursery crop production is predicated on optimized methods that apply saline irrigation without compromising plant success and health. Halophytes have many mechanisms of salt tolerance; however, these are greatly tied to physiological and developmental maturity. Thus, evaluating salt tolerance of halophytic crops (Hibiscus moscheutos and Kosteletzkya virginica) during seed germination and juvenile phases of life may provide insight into the efficacy of integrating poor quality water in horticultural operations.

Four seed priming methods (hydropriming, proline priming, low concentration halopriming, and high concentration halopriming) were evaluated as pre-sowing techniques to ameliorate …

Examining Biological Algal Harvest For Use In Clemson University’S Algal Carbon Capture System Using Freshwater Mussel Elliptio Complanata, Jack Grimes

All Theses

Capture of atmospheric carbon by freshwater algae is being proposed in Clemson University’s outdoor algal carbon capture system, formerly described as the Partitioned Aquaculture System (Drapcho and Brune, 2000). Several algal species have been present in the system, depending on cultivation conditions. However, mechanical harvesting of the algae has proven difficult because of the cost of chemical flocculants, the energy cost of filtration due to small particle size of algae, and the relatively dilute algal cell concentrations in the system. Prior research on algal filtration by freshwater mussels has indicated its potential for use as a biological filter. This research …

An Investigation Of The Impact Of Entrepreneurship Programs On Student Interest In Entrepreneurship Competitions, Toni Sharp

All Theses

According to a survey by ACNielsen International Research, over half of Americans want to start their own business to build wealth and achieve independence (Bygrave & Zacharakis, 2011). In the research community, most entrepreneurship education research happens in business schools (Matlay, 2006). As a result of continually researching one form of entrepreneurship, less attention has been paid to other forms contributing to the “definitional obscurity with important consequences for the direction of the field” of entrepreneurship (Baker & Welter, 2017). This has created a need for research on entrepreneurship at the college level in fields outside of business.

Clemson University …

Photodynamic Therapy To Treat Triple Negative Breast Cancer In Vitro, Hunter S. Warren

All Theses

Triple negative breast cancer (TNBC) is the most resilient form of breast cancer, being one of the leading causes of death for women and making up 7% of all cancer deaths. Photodynamic therapy (PDT) offers a minimally invasive solution to TNBC as a passive-targeting treatment that reduces the need for other well established yet harsh treatments that can be taxing on the patient. PDT involves the use of a high-energy red light on the area of a tumor injected with photosensitizers (PS) that generate reactive oxygen species (ROS) in the tumor, triggering cell death. The PS tetra(hydroxyphenyl)chlorin (m-THPC) was used …

Digital Hair Creation For Archaeological Facial Approximation: George Dixon, The Last Captain Of The Hl Hunley, Robert Emerson

All Theses

This study explores the application of digital hair creation techniques in archaeological facial approximation, focusing on the case of George Dixon, the last captain of the HL Hunley submarine. While digital hair creation techniques have been previously employed in facial approximation, this research seeks to investigate further their potential and advantages over traditional methods, particularly regarding flexibility and the ability to create multiple variations.

Facial approximation is a critical method for reconstructing the physical appearance of historical individuals. However, accurately recreating their hairstyle presents a significant challenge due to limited information and reliance on artistic interpretation. This research aims to …

Belonging By Design: The Exploration Of Architecture Learning Environments And Their Role In The Sense Of Belonging And Field Identity Of Black Architecture Students, Stacy Scott

All Dissertations

This research offers a comprehensive analysis of the various dimensions of belonging, isolation, and the role of identity in architecture learning environments (ALEs) for Black architecture students. In a multi-site case study, the study analyzes the experiences of Black students in the habitus that forms these ALEs at three universities with fifteen participants. Through qualitative investigation and thematic analysis, this research evaluates the obstacles these students face when endeavoring to establish meaningful connections.

The results of this study provide a greater understanding of the impact that isolation, lack of representation have on students and the significance of support-seeking activities in …

Addressing The Elephant In The Room: An Exploratory Multiple Case Study Of Principals’ Perceptions Of Opportunity Gaps, Their Leadership Practices And Access To Advanced Placement Courses For Marginalized Students, Parker Morse Andreoli

All Dissertations

Since the implementation of the No Child Left Behind (NCLB) Act, achievement gaps have guided education reform work. The focus on these gaps in student outcomes has been standardized and has lacked consideration of the inputs that create the academic achievement disparities between demographic groups of students. These gaps are often tied to the segregation of learning opportunities, both across and within schools, and perpetuate racist and classist stereotypes of students. A critical need to shift attention from gaps in achievement to a more appropriate measure, opportunity gaps between racially minoritized students and their White peers, is needed. In this …

Effect Of Authentic Kefir And Nigella Sativa On Broilers Challenged By Coccidia And Clostridium Perfringens, Julian E. Nixon

All Dissertations

Black seed oil concentrations of 0%, 0.1%, 1% and 5% were added to milk inoculated with kefir grains and incubated at 25°C for 22 h. The pH and microbial count indicated 1% black seed oil caused low inhibition (P > 0.05) of fermentation, but 5% black seed oil caused significant inhibition of the kefir microorganisms (P < 0.05).

Cobb 500 male chicks (n = 256) were distributed in a randomized block design and received one of four treatments: CTRL1 (Non-medicated, no kefir, no Clostridium perfringens), CTRL2 (Non-medicated, no kefir, C. perfringens inoculated), CTRL3 (BMD medicated, no kefir, C. perfringens inoculated), KTRT (Non-medicated, …

Mirna Regulation Of Skeletal Muscle Hypertrophy, Maslyn Greene

All Dissertations

Muscle tissue is vital to animal survival and economically essential to livestock producers. Reduced muscle growth can occur from various reasons, including genetics, nutrition, and the pre and postnatal environment. Understanding the mechanisms behind muscle growth can aid in developing strategies to increase muscle mass. Several methods to increase muscle mass in livestock animals are currently being pursued, including nutrition, hormonal therapy, and genetic selection. One newly developing avenue is using miRNA technologies to change the expression of protein-coding genes. miRNA are a type of RNA that regulate over half of protein-coding gene expression. Here we evaluate muscle characteristics such …

A Mixed-Method Study On The Walkability Of Streets In Hospital-Anchored Neighborhoods, Xiaowei Li

All Dissertations

The field of healthcare design is adopting planning and design principles from the Healthy Communities movement to connect hospitals to their adjacent communities. This research explores the impact of neighborhood and street design on the walkability of Hospital-Anchored Neighborhoods (HANs), a concept integrating hospitals and satellite services with their surrounding communities to enhance public health. Walkability, a crucial marker of healthy and vibrant communities, was investigated through a mixed-method study across three HANs. A comprehensive Walkability Framework with 17 built environment dimensions was developed from the literature to inform data collection utilizing GIS archival data, ethnographic observations, street audits, and …

In Vitro And In Vivo Diabetic Models For Assessment Of Tissue Engineered Vascular Grafts, Juan Carlos Carrillo Garcia

All Dissertations

Diabetes has become one of the leading causes of lower-limb loss worldwide. Every 30 seconds, a person loses a limb due to diabetic-related vascular complications. About one-third of patients needing lower-limb bypass surgery have debilitated autologous vessels unsuitable for use, and no other good long-term options are available. These detrimental effects on the vasculature are caused mainly by the hyperglycemic and hyperlipidemic conditions derived from diabetes. Under these conditions, an increase in advanced glycation end products (AGEs) and reactive oxygen species leads to irreversible crosslinks of extracellular matrix proteins, accelerating vascular pathology through vascular stiffening, endothelial dysfunction, inflammation, atherosclerosis, fibrosis, …

Voces Perdidas: Latinx Dacamented College Students' Access To U.S. Healthcare, Alicia Delia Pola

All Dissertations

Objective. The purpose of this dissertation study was to examine the lived experiences of LatinX DACAmented college students and their perceptions of access to healthcare in the U.S. and purposefully share the stories told to enact social change. This study amplifies the voices of these college students and centers their lived experiences as worthy of being heard. Additionally, this study acknowledges the impacts of structural and systemic inequalities that have led to discriminatory legislation that consequently segregates healthcare services for undocumented immigrants. Method. This study used Critical Race Theory (CRT) and Social Determinant of Health (SDOH) model as analytic frameworks …

Clemson University Board Of Trustees, Finance And Facilities Committee, 2023 July 20, Clemson University Board Of Trustees

Minutes

No abstract provided.

Clemson University Board Of Trustees, Full Board Minutes, 2023 July 20, Clemson University Board Of Trustees

Minutes

No abstract provided.

Isolation Of Bovine Milk-Derived Exosomes Via A Polyester Capillary- Channeled Polymer (C-Cp) Fiber Stationary Phase, Jerisa Pimentel, Carolina Mata, R. Kenneth Marcus

Chemistry Summer Research Program

No abstract provided.

Virginia Woolf As Mother Tree, Catherine W. Hollis

Virginia Woolf: Selected Papers

No abstract provided.

Clemson Commencement Program, May 2023, Clemson University

Clemson Commencement Programs

No abstract provided.

The Role Of Fto, A Human Rna Demethylase In Perennial Grass Development And Abiotic Stress Responses, Andrew Fiorentino, Qian Hu, Xiaotong Chen, Zhaohui Chen

Honors College Theses

The integration of the human fat mass and obesity associated (FTO) gene into turfgrass is a novel approach at improving cell proliferation and abiotic stress resistance. The FTO protein is an RNA demethylase responsible for epigenetic regulation of the genome. In related rice, the gene is associated with increased crop yield, tiller number, and aerial biomass. It is proposed to work via demethylation of repeat RNA associated with chromatin remodeling, causing widespread transcriptional activation. In this study, the feasibility of using FTO for plant trait modification in perennial grasses is being investigated. Potentially transformed embryogenic calli of creeping bentgrass with …

Clemson University Women Trailblazers, A. M. Alexander, J. W. Harris

Clemson University Women Trailblazers

No abstract provided.

Fabrication And Characterization Of A Nanofiber Composite Biosensor For Chronic Wound Inflammation Diagnosis, Shreya Thammana

Honors College Theses

Chronic wounds (wounds that fail to proceed through the normal phases of wound healing and cannot restore to full function in three months) can pose physical and financial burdens on patients. The most common chronic wound is diabetic foot ulcers, which affect 6.3% of the global population [1]. Current diagnostic and tracking methods to monitor wound healing are subjective and involve visual inspection and observation of the wound as it heals. However, when dealing with chronic wounds, the wound healing process is more difficult to observe due to the delayed nature of healing. There is also a need to closely …

An In Vivo Biocompatibility Analysis Of A Novel Tissue Regeneration Matrix Using A Pig Model, Shamar Thomas

All Theses

The goal of this project is to develop an injectable bead scaffold to promote tissue regeneration in the void created by lumpectomy and to alleviate post lumpectomy problems by preventing local recurrence and minimizing surgical-related infections. Microbeads were synthesized from collagen type I and crosslinked with tannic acid to form the basis for this injectable therapeutic. Tannic acid acts as a therapeutic anticancer agent. The action mechanisms of tannins in breast cancer cells have been studied with studies showing tannins to be cytotoxic to cancer cells in a dose-dependent manner. Tannic acid induces apoptosis in breast cancer cells via caspase …

An Assessment Of Information And Education As A Factor Of Agricultural Development And Sustainability In South Carolina, George Strickland

All Theses

Across the Southeastern United States, producers in the agricultural industry wage a constant struggle between combating negative economic impacts and discovering economic opportunity. Harmful Algal Blooms (HABs) represent a crisis with wide-ranging economic impacts. The management of HABs presents a critical challenge for addressing the level of knowledge (LOK) and adaptability of Extension agents. Conversely, the emergence of markets for local and organic produce represents a burgeoning economic opportunity for producers. The growing trend of including more kale in the everyday American diet demands an assessment of those opportunities for local producers.

To identify the WTP for organic and local …

A Systematic Review Of Research On Treatment & Prevention Of The Neglected Tropical Disease Leishmaniasis, Aryn Akerberg

All Theses

Leishmaniasis is a life-threatening neglected tropical disease that is caused by the protozoa parasite, Leishmania. Over one million new human leishmaniasis cases occur each all over the world, affecting most the deeply impoverished regions of the world. The disease presents in three different forms: cutaneous leishmaniasis, mucocutaneous (mucosal) leishmaniasis, and visceral leishmaniasis. Symptoms can range from self-limiting lesion to more life-threatening conditions such as fever, kidney disease, and anemia. The Leishmania parasite is transmitted via the bite of the female phlebotomine sandfly and can infect many other mammals such as canines, rodents, bats, etc. The canine leishmaniasis epidemic is also …

Drivers Of White-Tailed Deer (Odocoileus Virginianus) Behavior, Survival, And Population Growth In The Piedmont Of South Carolina, Michael Muthersbaugh

All Dissertations

Prey species adjust behaviors in response to various stimuli, responding to both top-down and bottom-up pressures. Large herbivores must attempt to avoid predation either through adjusting behaviors or seeking spatial or temporal refugia, which can scale up to influence individual fitness and ultimately population dynamics. Specifically, predation risk has a great potential to influence ungulate populations by impacting behaviors and survival. Our objective was to quantify ungulate behavioral and population response to a regionally important predator through a case study – white-tailed deer (Odocoileus virginianus) responses to coyotes (Canis latrans) on private lands in the Piedmont …

Glycolytic Inhibitors As Leads For Drug Discovery In The Pathogenic Free-Living Amoebae, Jillian Milanes

All Dissertations

The free-living amoeba, Naegleria fowleri, can cause a rare yet usually lethal infection of the brain called primary amebic meningoencephalitis. Because of poor diagnostics and limited treatment options, the mortality rate associated with the disease is >97%. Due to our finding that glucose is critical for trophozoite growth in culture, we have been interested in exploiting amoebae glucose metabolism to identify new potential drug targets. We have characterized the first enzyme of the glycolytic pathway, glucokinase (Glck), from N. fowleri and two other pathogenic free-living amoeba, Acanthamoeba castellanii and Balamuthia mandrillaris. We have assessed their biochemical properties and …

A Systematic Review Of Factors Associated With Sport Participation Among Adolescent Females, Casey S. Hopkins, Chris Hopkins, Samantha Kanny, Amanda Watson

Honors College Theses

Sports participation provides a direct means to attain health-enhancing physical activity, however, participation in sport declines during adolescence and over 85% of adolescent females fail to meet recommended levels of physical activity. Given the importance of overcoming barriers to sport and increasing equity in women’s sports, the purpose of this systematic review was to identify factors associated with sport participation among adolescent girls and operationalize those factors into theoretical constructs to guide future research. Six databases were systematically searched and 36 records were included for review. Factors impacting girls’ sport participation were categorized as personal, peer, family, socioeconomic, environmental, or …

Role Of Salinity In Perfluorooctane Sulfonate (Pfos) Bioconcentration Between Aquatic Species And The Differential Regulation Of Transporters In Fundulus Heteroclitus, Tyler Davis

All Theses

Perfluorooctane sulfonate (PFOS) is a persistent organic pollutant that is known for its surfactant properties and its resistance to degradation. The persistence and lipophilicity of PFOS in surface waters have led to its bioaccumulation in fish, which in turn leads to its accumulation and toxic effects in humans that consume fish. PFOS is also hypothesized to perturb reproduction and survival of low and mid-trophic level zooplankton species such as Daphnia magna that are food for multiple fish species. In this study, a 21-day D. magna chronic toxicity test was performed using 1,10, 100, 1000, and 5000 ppb of PFOS to …

Influence Of Potassium Fertilizer Application Timing On Cotton Production As Related To Soil Potassium On U.S. Coastal Plain Soils, Shruthy Suresh Kumar

All Theses

Understanding soil K dynamics is highly significant in cotton production owing to its prominent role in cotton fiber quality. About 31 % of cotton production in the U.S. is concentrated in SE states, with coastal plain soils having low innate K availability. Crop fertilizer-K recommendations are primarily made worldwide and across the U.S. using pre-plant STK concentrations. A literature review on cotton K studies suggests that fertilizer-K recommendations based on pre-plant STK concentrations alone need fine-tuning to meet the increasing K demands in modern cultivars, variations in crop K requirement patterns, and varied soil K supplying capacity. Studies have been …

Prey Preference Of Chrysoperla Rufilabris (Burmeister) (Neuroptera: Chrysopidae) For Three Common Pest Species Of Greenhouse Crops, Caitlin Silva

All Theses

Chrysoperla rufilabris (Burmeister) (Neuroptera: Chrysopidae) larvae are voracious generalist predators and important biological control agents on greenhouse crops. This study investigated the prey preference of second-instar C. rufilabris for three common greenhouse pests, namely the twospotted spider mite, Tetranychus urticae Koch (Acari: Tetranychidae), the Madeira mealybug, Phenacoccus madeirensis Green (Hemiptera: Pseudococcidae), and the melon aphid, Aphis gossypii Glover (Hemiptera: Aphididae). This study also investigated the influence of prey density ratios on the preference of C. rufilabris larvae for T. urticae and A. gossypii. Prey species preference was evaluated in no-choice, two-choice, and all-choice laboratory bioassays. In the no-choice bioassays, …