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Articles 961 - 990 of 6179
Full-Text Articles in Entire DC Network
Understanding The Effect Of Nanointerfaces On Nanostructure And Mechanical Properties Of Semicrystalline Polymers Using Coarse-Grained Molecular Dynamic Simulations, Nayoung Kim
Honors College Theses
Polymer crystallization is a classical problem of polymer research. Many synthetic and natural polymers take the semi-crystalline form. Crystallization of polymers is a complex process associated with the partial alignment of their molecular chains. The final physical properties of semicrystalline polymers are determined by the degree of crystallinity and the size and orientation of the crystallites (nano- to micro-sized crystalline regions). Although it has been studied for many years, we still lack a fundamental understanding of the types of factors that influence the semicrystalline structure and how the structure affects the final properties. It is difficult because crystalline polymers are …
Involving Athletes: Implementing A Human Resource Development Approach Among The Ncaa And Member Institutions, Angela D. Carter, Sarah Stokowski, Chris Corr, Skye G. Arthur-Banning
Involving Athletes: Implementing A Human Resource Development Approach Among The Ncaa And Member Institutions, Angela D. Carter, Sarah Stokowski, Chris Corr, Skye G. Arthur-Banning
Publications
No abstract provided.
Biochemical Analysis Of Dna Glycosylase In Dragonfish (Scleropages Formosus, Sfo) Tdg, Jenna Perry
Biochemical Analysis Of Dna Glycosylase In Dragonfish (Scleropages Formosus, Sfo) Tdg, Jenna Perry
Honors College Theses
TDG, which is a member of the uracil DNA glycosylase superfamily, plays a critical role in the active demethylation process in mammals by removing oxidized derivatives of 5-methylcytosine (mC). While human TDG has been extensively studied and found to possess 5-formylcytosine and 5-carboxylcytosine DNA glycosylase activity, little is known regarding this demethylation process in vertebrates other than the human species. Previous research proposed a catalytic sequence in motif 1 of zebrafish TDG1 and TDG2 that modulates DNA glycosylase activity based on mutational, kinetic, and modeling analyses of these enzymes. Building on this work, researchers discovered that the Sfo TDG is …
Long-Time Stability For An Imex Discretization Of The 1d Fujita Equation, Victoria Luongo
Long-Time Stability For An Imex Discretization Of The 1d Fujita Equation, Victoria Luongo
Honors College Theses
We study an efficient time-stepping scheme for the 1D Fujita equation that is implicit for the linear terms but explicit for the nonlinear terms. We analyze the long-time stability of the scheme for varying parameter values, which reveal parameter value regimes in which the method is stable. We provide numerical results that illustrate the theory and show the analytically derived stability conditions are sufficient to achieve long-time stability results.
Function Of Septin Proteins In Cryptococcus Neoformans In Cell Wall And Plasma Membrane Integrity And Homeostasis, Emma Hatchell
Function Of Septin Proteins In Cryptococcus Neoformans In Cell Wall And Plasma Membrane Integrity And Homeostasis, Emma Hatchell
Honors College Theses
Cryptococcus neoformans is a pathogenic basidiomycetous yeast that causes meningitis in immunocompromised patients. This lethal fungus is sometimes referred to as the “sugar coated killer” due to its polysaccharide capsule. It is estimated that 152,000 cases of cryptococcal infection occur each year and result in 112,000 deaths. The ability of C. neoformans to adapt to host temperature is a main factor responsible for virulence. Septins are conserved filament-forming GTPases that are confirmed to be involved in cytokinesis and morphogenesis and have been implicated in heat stress response and virulence of C. neoformans. C. neoformans genome encodes four septins, Cdc3, …
Investigating The Role Of Cytochrome P450 Enzymes In Triazole Drug Efficacy And Toxicity In Whole Organism Zebrafish Model, Heather Cosh
Investigating The Role Of Cytochrome P450 Enzymes In Triazole Drug Efficacy And Toxicity In Whole Organism Zebrafish Model, Heather Cosh
Honors College Theses
Invasive fungal infections account for nearly 1.5 million deaths a year and therefore are considered one of the leading causes of death worldwide. The first line of therapy towards these infections are antifungal drugs in the triazole class such as voriconazole, posaconazole, itraconazole, and isavuconazole. However, these antifungal drug therapies fail in a large number of patients and can produce toxic side effects, therefore increasing the risk of mortality worldwide. While prior research has demonstrated the efficacy of these drugs in mitigating fungal growth in vitro, it is unclear why these drugs fail to protect patients infected with fungal …
Optical Sensing Of Capillary Waves, Matthew Franklin Reid
Optical Sensing Of Capillary Waves, Matthew Franklin Reid
Honors College Theses
I relay various topics I learned about this semester and summarize the specialties of Clemson’s Micro-Photonics Laboratory. I report pertinent information for characterizing capillary waves with lasers and one recent method of characterizing them. Lastly, I outline a potential plan for mathematically modeling a laser’s reflection off of capillary waves, and potential plans moving forward.
Fbh1-Deficient Cells Exhibit A Dampened Stress Response To Wee1 Inhibition, Lucy Jennings
Fbh1-Deficient Cells Exhibit A Dampened Stress Response To Wee1 Inhibition, Lucy Jennings
Honors College Theses
Cancer is defined by uncontrolled growth from irregular activity by cell cycle proteins; recently, some cell cycle regulators have become attractive targets for cancer therapies. One of these targets is WEE1, a tyrosine kinase that phosphorylates tyrosine 15 (Y15) on CDK1 to stop the progression from G2 into mitosis. FBH1 is a DNA helicase critical for the induction of apoptosis in response to replication stress. Importantly, FBH1 is lost in many melanomas. FBH1 cooperates with MUS81 to create double-strand breaks and induce cell death. We hypothesized that the replication stress response in FBH1-deficient cells depends on the WEE1-dependent G2/M checkpoint …
Comparing Development Of Drug Resistance By Cryptococcus Neoformans To Chemically Distinct Azole Anti-Fungal Compounds, Lindsey Burke
Comparing Development Of Drug Resistance By Cryptococcus Neoformans To Chemically Distinct Azole Anti-Fungal Compounds, Lindsey Burke
Honors College Theses
Cryptococcus neoformans is a fungus that primarily infects humans who have weakened immune systems. An azole drug, Fluconazole, is commonly administered against C. neoformans in regions were cryptococcosis is most prevalent, most notably Sub-Saharan Africa. However, C. neoformans can gain resistance to Fluconazole through becoming an aneuploid. To better understand the basis of resistance, we employed a disk diffusion assay and investigated several chemically-distinct azole compounds with anticryptococcal properties for their effectiveness against C. neoformans and to identify potential differences in the capacity of the fungus to become resistant to each of the tested compounds. Different C. neoformans strains were …
Fabrication And Characterization Of A Nanofiber Composite Biosensor For Chronic Wound Inflammation Diagnosis, Shreya Thammana
Fabrication And Characterization Of A Nanofiber Composite Biosensor For Chronic Wound Inflammation Diagnosis, Shreya Thammana
Honors College Theses
Chronic wounds (wounds that fail to proceed through the normal phases of wound healing and cannot restore to full function in three months) can pose physical and financial burdens on patients. The most common chronic wound is diabetic foot ulcers, which affect 6.3% of the global population [1]. Current diagnostic and tracking methods to monitor wound healing are subjective and involve visual inspection and observation of the wound as it heals. However, when dealing with chronic wounds, the wound healing process is more difficult to observe due to the delayed nature of healing. There is also a need to closely …
Development Of 3d Ovarian Cancer Spheroids In Vitro And Investigation Of Their Physiological Relevance As Models Of Inherent Chemoresistance, Amanda Murray
Honors College Theses
Ovarian cancer is the sixth leading cause of death among women worldwide, with an average 5-year survival rate of less than 48%. Current clinical treatment methods for this disease are often deemed ineffective because of the innate chemoresistance of tumors due to their microenvironment and architecture. Accurately mimicking chemoresistance with traditional 2D cultures is difficult; therefore, recent years have seen an increase in 3D culturing methods that create cellular spheroids. These spheroids can serve as models of in vivo tumor characteristics due to their hypoxic core, acidic microenvironment, and increased cell-to-cell interactions. This research aims to (1) refine a 3D …
Politics, Players, And Legislation In The California Housing Crisis, Andy Daly
Politics, Players, And Legislation In The California Housing Crisis, Andy Daly
All Theses
California has faced a statewide housing shortage for three decades, particularly in exclusive job-rich cities that are becoming increasingly unaffordable. In response, the state has passed pro-housing legislation that bypasses local zoning regulations, focusing on increasing the construction of affordable housing units. I conducted a convergent content analysis of over 80 articles and eight expert interviews. I found that state-led housing legislation is most effective when politicians align their messaging with other pressing issues, such as climate change, transit, and homelessness. Even if bills are rejected, progress is made by opening conversations about the importance of density and housing affordability. …
An In Vivo Biocompatibility Analysis Of A Novel Tissue Regeneration Matrix Using A Pig Model, Shamar Thomas
An In Vivo Biocompatibility Analysis Of A Novel Tissue Regeneration Matrix Using A Pig Model, Shamar Thomas
All Theses
The goal of this project is to develop an injectable bead scaffold to promote tissue regeneration in the void created by lumpectomy and to alleviate post lumpectomy problems by preventing local recurrence and minimizing surgical-related infections. Microbeads were synthesized from collagen type I and crosslinked with tannic acid to form the basis for this injectable therapeutic. Tannic acid acts as a therapeutic anticancer agent. The action mechanisms of tannins in breast cancer cells have been studied with studies showing tannins to be cytotoxic to cancer cells in a dose-dependent manner. Tannic acid induces apoptosis in breast cancer cells via caspase …
Using Visual Effects As A Means Of Establishing Or Reinforcing Scale In 3d Visual Works, Eric Dinicolantonio
Using Visual Effects As A Means Of Establishing Or Reinforcing Scale In 3d Visual Works, Eric Dinicolantonio
All Theses
In 3D animation, visual effects help to establish and reinforce the scale of different characters and objects that are otherwise unclear. In the Fall of 2022, I taught a class about visual effects to several students. At the time, I had difficulty explaining the importance of properly scaling your 3D effects in order to add realism. With physically based effects, we must respect the laws of physics to create a visually realistic and understandable visual effect. Going through several of my previous projects, I found that I had made mistakes with scaling several of my effects. With this paper, I …
A Hidden Spider Web Of Roots: Utilizing Ground Penetrating Radar To Uncover Laterally Expansive Roots Of An Oak Tree, Megan Lapkoff
A Hidden Spider Web Of Roots: Utilizing Ground Penetrating Radar To Uncover Laterally Expansive Roots Of An Oak Tree, Megan Lapkoff
All Theses
Roots are critical to understanding tree health, subsurface biomass, and overall tree root stability. However, accessing tree roots is difficult and traditional methods used to quantify roots harm or kill the tree. Ground penetrating radar (GPR) provides a non-invasive way to characterize subsurface roots without harming the tree. GPR provides high-resolution data and the ability to collect data with high spatial coverage, making it an ideal tool for characterizing roots. GPR works by detecting contrasts in dielectric permittivity or electromagnetic (EM) velocity at interfaces between materials. Small scattering objects, like roots, generate predictable artifacts called diffraction hyperbolas. Diffraction hyperbolas will …
Perspective And Perception: How Reddit Trip Reports Convey And Offer Different Knowledges About Psychedelic Drugs, Kevin Lawson Nutt
Perspective And Perception: How Reddit Trip Reports Convey And Offer Different Knowledges About Psychedelic Drugs, Kevin Lawson Nutt
All Theses
Psychedelics drugs are slowly gaining recognition for their potential medicinal value in therapeutic settings in Western science. However, there remains a great deal of hostility and hesitancy toward psychedelics, largely due to the psychedelics’ collective classification as Schedule I drugs in America, which resulted from a history of the drug class’ demonization. Nonetheless, several US states and cities having decriminalized psychedelic drugs in certain contexts, but the general population is relatively naïve to the potentialities psychedelics can offer. This thesis studies trip reports, which are firsthand accounts of individual psychedelic experiences, on Reddit to shed light on the different knowledges …
Evaluating The Effect Of Palmitic Acid Concentration On Growth And Inhibition Of Syntrophomonas Sp., Clancy Kerr
Evaluating The Effect Of Palmitic Acid Concentration On Growth And Inhibition Of Syntrophomonas Sp., Clancy Kerr
All Theses
Various industries produce fats, oils, and greases (FOG). These hydrophobic compounds cause issues in municipal wastewater collection and treatment systems. Anaerobic co-digestion is an effective way to treat FOG and presents an opportunity to produce more significant quantities of biogas. However, many microorganisms are sensitive to the degradation products like long-chain fatty acids (LCFAs). Palmitic acid is the most prevalent LCFA in anaerobic co-digestion of FOG and wastewater. Sytrophomonas is a β-oxidizer able to break down palmitic acid. Palmitic acid is known to feed and inhibit Syntrophomonas growth and methanogenesis. The objectives of this investigation are: To determine if Syntrophomonas …
Autoethnography As Self-Portrait: An Autoethnographic Analysis Of Trauma-Sensemaking Through Art, Kally Werning
Autoethnography As Self-Portrait: An Autoethnographic Analysis Of Trauma-Sensemaking Through Art, Kally Werning
All Theses
This project thesis is centered around coping with early onset childhood trauma through an autoethnography of narrative and art creation. The goal of this project is to understand more deeply how the art making process synthesizes or disrupts trauma sense-making through the introspective lens of the artist as scholar. The project consists of an interactive art exhibit and this written scholarly analysis of the creation and display of this exhibit. This includes an introduction to my life as a trauma survivor and Greek-American woman, informed by communication scholarship and other relevant fields regarding narrative theory, Greek history, religious and trauma …
Nightmares And Hand Grenades: Dreams As A Storytelling Tool, Olivia Felber
Nightmares And Hand Grenades: Dreams As A Storytelling Tool, Olivia Felber
All Theses
Dreams and nightmares feature prominently in art, story, and religious practice and tradition throughout history. In this paper I will discuss their prominence throughout these facets in daily life, and the various ways that we, as humans, have tried to elucidate meaning from them. I will study the nature and definition of dreams and nightmares through a scientific, cultural, and historical approach. I will also discuss folklore and the interpretation of nightmarish imagery in the context of an otherworldly adventure through a nightmare. These topics and themes will be shown, explained, and discussed through the methodology of my project- a …
A Systematic Review Of Research On Treatment & Prevention Of The Neglected Tropical Disease Leishmaniasis, Aryn Akerberg
A Systematic Review Of Research On Treatment & Prevention Of The Neglected Tropical Disease Leishmaniasis, Aryn Akerberg
All Theses
Leishmaniasis is a life-threatening neglected tropical disease that is caused by the protozoa parasite, Leishmania. Over one million new human leishmaniasis cases occur each all over the world, affecting most the deeply impoverished regions of the world. The disease presents in three different forms: cutaneous leishmaniasis, mucocutaneous (mucosal) leishmaniasis, and visceral leishmaniasis. Symptoms can range from self-limiting lesion to more life-threatening conditions such as fever, kidney disease, and anemia. The Leishmania parasite is transmitted via the bite of the female phlebotomine sandfly and can infect many other mammals such as canines, rodents, bats, etc. The canine leishmaniasis epidemic is also …
A Multi-Agent Modeling Social Network Analysis Of Cooperative Learning Groups Within A Simulated Adult Education Classroom Learning Environment, Leverett Bruner
A Multi-Agent Modeling Social Network Analysis Of Cooperative Learning Groups Within A Simulated Adult Education Classroom Learning Environment, Leverett Bruner
All Dissertations
Illiteracy and a lack of a high school diploma are impediments to a fulfilled and meaningful life. Low or reduced literacy and non-attainment of a high school diploma are significant problems in the United States. Adult education can be a vehicle to address these ever-present issues. A disproportionate number of students in adult education are minorities, members of lower socioeconomic statuses and traditionally marginalized groups who lack effective literacy skills and/or a high school diploma. Adult education and its related entities can serve as a vehicle to address these pervasive issues, but adult education as a program type is a …
Partitioning And Microdosimetry Of Plutonium-239 And 55-Iron In Environmental Bacteria Grown In Liquid Cultures, Lisa Manglass
Partitioning And Microdosimetry Of Plutonium-239 And 55-Iron In Environmental Bacteria Grown In Liquid Cultures, Lisa Manglass
All Dissertations
The work presented herein provides quantitative data related to bacteria exposed in situ to two radionuclides relevant to nuclear sensing: plutonium-239 (239Pu) and iron-55 (55Fe). Originally motivated by the fundamental science underlying biosensing, liquid cultures of Pseudomonas putida and Escherichia coli were exposed to radionuclides over the course of 15-day experimental periods with the intent of gaining insight into the response of these bacteria. An essential component of characterizing or utilizing this response in a meaningful way is an understanding of the dose leading to that response. This dissertation narrows the knowledge gap associated with dose-response …
Addressing Vaccine Hesitancy Through A Trust In Science Training Intervention, Nathan Dumessa
Addressing Vaccine Hesitancy Through A Trust In Science Training Intervention, Nathan Dumessa
All Dissertations
Vaccine hesitancy is an ongoing public health issue that has been underscored by the COVID-19 pandemic and has implications for future pandemics and other vaccines. This research aimed to understand and address the factors associated with hesitancy. Study 1 was a correlational study that measured several factors that could predict vaccine hesitancy among Black and White participants recruited online (n = 364). Findings suggest that trust in science was the strongest predictor of attitudes towards the vaccine’s safety and effectiveness, which in turn strongly predicted vaccine hesitancy. Study 1 established the direct and indirect relationships between several predictors of …
Making Of Wars: Analysis Of The Franchise Management Of God Of War And Gears Of War, William Seaton
Making Of Wars: Analysis Of The Franchise Management Of God Of War And Gears Of War, William Seaton
All Theses
Two of the most prominent franchises in the video game industry are God of War and Gears of War. These franchises, produced by Sony Interactive Entertainment (SIE) and Xbox Game Studios (XGS), respectively, and their presentation through company blogs offer insight into the franchise management strategies and franchise conceptualizations that their parent companies have. Understanding these franchising aspects furthers knowledge on how these companies, two of the three largest video game producers, engage in franchising behaviors through discourse. Utilizing a framework of the discourse of franchise paratexts, this thesis examines those franchising tactics and discursive frames that the companies …
Refigured: Separations In Portraiture, Caroline Myers
Refigured: Separations In Portraiture, Caroline Myers
All Theses
Utilizing traditional painting techniques embedded with digital syntaxes, Refigured: Separations in Portraiture, serves as a catalog of my experiences with communication in a hyperconnected world. Processing illegible information caused by my hearing loss informs the process of imposing similar boundaries within my paintings. Like a technical glitch, these obstructions create an illegible visual experience, with evidence of my process remaining as a clue for the viewer’s understanding of the image.
Though personal in nature, I expand from my experience with auditory communication to employ pertinent explorations into the sustained unpredictability of today’s ever-expanding medium that is technology. My paintings …
Advancement Of Detection And Treatment For Triple-Negative Breast Cancer And Infectious Disease, Austin Smothers
Advancement Of Detection And Treatment For Triple-Negative Breast Cancer And Infectious Disease, Austin Smothers
All Dissertations
Triple-negative breast cancer (TNBC) continues to be one of the leading causes of death in women, making up 7% of all cancer deaths. Tumor-treating electric fields (TTFields) are low-energy, low-frequency oscillating electric fields (OEF) that have been shown to induce an anti-proliferative effect on mitotic cells in glioblastoma multiforme (GBM), non-small cell lung cancer (NSCLC), and ovarian cancer. Currently, tumor-treating field (TTField) therapy utilizes “optimal” frequencies of electric fields to achieve maximal cell death by cell line. However, because of differences in cell size, shape, and ploidy during mitosis, optimal electric field characteristics for maximal cell death may not exist. …
Glycolytic Inhibitors As Leads For Drug Discovery In The Pathogenic Free-Living Amoebae, Jillian Milanes
Glycolytic Inhibitors As Leads For Drug Discovery In The Pathogenic Free-Living Amoebae, Jillian Milanes
All Dissertations
The free-living amoeba, Naegleria fowleri, can cause a rare yet usually lethal infection of the brain called primary amebic meningoencephalitis. Because of poor diagnostics and limited treatment options, the mortality rate associated with the disease is >97%. Due to our finding that glucose is critical for trophozoite growth in culture, we have been interested in exploiting amoebae glucose metabolism to identify new potential drug targets. We have characterized the first enzyme of the glycolytic pathway, glucokinase (Glck), from N. fowleri and two other pathogenic free-living amoeba, Acanthamoeba castellanii and Balamuthia mandrillaris. We have assessed their biochemical properties and …
Mechanical Evaluation Of In Vitro Simulated Myocardial Infarction, Caroline Peak
Mechanical Evaluation Of In Vitro Simulated Myocardial Infarction, Caroline Peak
Honors College Theses
The leading cause of death worldwide is cardiovascular disease, responsible for 32% of all global deaths and the leading cause of death for men and women across most racial and ethnic groups in the United States [1]. Between 2016 and 2017, cardiovascular disease cost the U.S. $363 billion in medical costs, research, and healthcare services [1].
Finding new therapies to treat heart disease is very slow and very expensive, which has driven many research companies to develop in vitro screening platforms for testing therapies in cultured cardiac tissue. In Clemson University’s Systems Mechanobiology Lab under the leadership of Dr. Will …
A Systematic Review Of Factors Associated With Sport Participation Among Adolescent Females, Casey S. Hopkins, Chris Hopkins, Samantha Kanny, Amanda Watson
A Systematic Review Of Factors Associated With Sport Participation Among Adolescent Females, Casey S. Hopkins, Chris Hopkins, Samantha Kanny, Amanda Watson
Honors College Theses
Sports participation provides a direct means to attain health-enhancing physical activity, however, participation in sport declines during adolescence and over 85% of adolescent females fail to meet recommended levels of physical activity. Given the importance of overcoming barriers to sport and increasing equity in women’s sports, the purpose of this systematic review was to identify factors associated with sport participation among adolescent girls and operationalize those factors into theoretical constructs to guide future research. Six databases were systematically searched and 36 records were included for review. Factors impacting girls’ sport participation were categorized as personal, peer, family, socioeconomic, environmental, or …
Investigating The Role Of Cnag_05113 In The Carnitine Biosynthesis Pathway In Cryptococcus Neoformans., Jasmine Meltzer, Rodrigo Catalan-Hurtado, Perry Kezh, Kerry Smith
Investigating The Role Of Cnag_05113 In The Carnitine Biosynthesis Pathway In Cryptococcus Neoformans., Jasmine Meltzer, Rodrigo Catalan-Hurtado, Perry Kezh, Kerry Smith
Honors College Theses
Cryptococcus neoformans, the leading cause of fungal meningitis, is a fungal pathogen that causes severe infection of the central nervous system in patients with compromised immune systems, typically caused by HIV/AIDS. C. neoformans infections are present in developed countries including the United States, but most fatalities occur in sub-Saharan Africa where antiretroviral therapy, the treatment for HIV/AIDS, is less accessible. Current treatments for severe cryptococcal infections are extensive and outdated. There is a critical need for an improved understanding of the fungus and new targeted therapies. Our goal is to identify metabolic pathways important to the survival of C. …