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Anticancer Properties Of Research-Grade Hydrastis Canadensis (Goldenseal) And Characterization Of Its Effect On The Mdr1-Encoded Phosphoglycoprotein Efflux Pump, Sara Garrett Aug 2009

Anticancer Properties Of Research-Grade Hydrastis Canadensis (Goldenseal) And Characterization Of Its Effect On The Mdr1-Encoded Phosphoglycoprotein Efflux Pump, Sara Garrett

All Theses

Multiple drug resistance (MDR) in tumors, observed both in vivo and in vitro, is generally attributed to efflux-mediated reduced drug accumulation via mdr1/P-gp. Notoriously chemoresistant colorectal cancers exhibit the highest P-gp expression, account for 9% of all cancer deaths, and are the third most common cancer in men and women. P-gp, a 170kDa protein, contains twelve transmembrane segments with two ATP-binding domains used to extrude intracellular compounds of broad specificity against a concentration gradient. Studies concerning natural health products are becoming more prevalent in the search for safe anti-P-gp remedies and Hydrastis canadensis (goldenseal) was studied for its anti-cancer properties. …

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Ripe For Change: Roles Of Planners And Landscape Architects At The Interface Of The Land And The Network In An Alternative Agriculture Model For Upstate South Carolina, Jennifer Johnson Aug 2009

Ripe For Change: Roles Of Planners And Landscape Architects At The Interface Of The Land And The Network In An Alternative Agriculture Model For Upstate South Carolina, Jennifer Johnson

All Theses

Both historically and in select areas today, local food systems are the main food supply for communities. Despite the fact that they are not a main source of food for most Americans, since the 1970s there has been a resurgence of U.S. local food systems (Qazi & Selfa, p.161). The movements exist in places where high-profile and vocal personalities (restaurateur, Alice Waters; author, Michael Pollan; or activist Carlo Petrini) also reside. This thesis examines whether the viability of the resurgence in local food systems depends on the commitment of a single person, and if not, whether those who affect the …

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Twenty Miles To Rome: The Story Of South Carolina's First Medal Of Honor Winner In World War Ii, Charles Taylor Aug 2009

Twenty Miles To Rome: The Story Of South Carolina's First Medal Of Honor Winner In World War Ii, Charles Taylor

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This thesis, which has encompassed my life for the last several months, began as sort of an afterthought. A graduate course that I was taking in fall 2008 required the students to produce a prospectus for a new biography that should be added to the historical record. Looking to find a subject that I did not mind researching, I chose to write a proposal on my great uncle Furman L. Smith, who was South Carolina's first Congressional Medal of Honor winner in World War II. I had always had an interest in family history, but felt guilty that I knew …

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Effects Of Meeting Spaces On The Performance Of A Concept Selection Task By Engineering Design Teams, Necmettin Ozkan Aug 2009

Effects Of Meeting Spaces On The Performance Of A Concept Selection Task By Engineering Design Teams, Necmettin Ozkan

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Given the increasing importance of collaboration and the resulting use of virtual tools, this research investigates the performance of engineering design teams using a concept selection task in three meeting spaces, face-to-face, 2D online and 3D virtual. Cisco's WebEx and Sun Microsystems' Wonderland were used as the 2D online meeting space and the 3D virtual environment, respectively. Twenty-four two-person design teams were formed and randomly assigned to the meeting spaces. Eight teams performed a cell-phone concept selection task in each meeting space. Four dependent variables were measured: task completion time, team satisfaction, self-evaluated quality and expert-evaluated quality. Following data collection, …

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Leaching Of Dissolved Organic Carbon And Selected Inorganic Constituents From Scrap Tires, Meric Selbes Aug 2009

Leaching Of Dissolved Organic Carbon And Selected Inorganic Constituents From Scrap Tires, Meric Selbes

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An environmentally friendly method for the disposal of scrap tires is currently unavailable; as a result, ultimate disposal of used vehicle tires continues to be a major challenge around the world. In the United States (US), during the past two decades, scrap tires have been generated at the rate of approximately one tire per person per year (i.e., approximately 290 million new scrap tires every year). It is estimated that there are currently 2 billion tires stockpiled in the US. Due to various problems involved in the disposal of scrap tires, different alternatives for recycle and reuse have been examined; …

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The Impact Of Drm Technology In The P2p Age, Ying Xin Aug 2009

The Impact Of Drm Technology In The P2p Age, Ying Xin

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The innovation of P2P technology in digital world challenges the present copyright institutions and retailers. People are declined to look for the protection from the traditional law in digital circumstance. As the trend of extending copyright protection term across the world, most intellectual property institutions implement new technologies to deal with such situation. This paper uses a panel of country-level data to investigate the extent to which this is a consequence of the extension of copyright protection. Utilizing the economic model, the analysis suggests that the economic effects of implementing DRM technology are generally negative, albeit uncertain. The available evidence …

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Clemson Trustees Minutes, 2009 July 17, Clemson University Board Of Trustees Jul 2009

Clemson Trustees Minutes, 2009 July 17, Clemson University Board Of Trustees

Minutes

Minutes: Meeting of the Clemson University Board of Trustees. Executive Board Room, Madren Center, Clemson, SC. 10:30 a.m.

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Options For Anderson County School Districts, 2009 June, Holley Hewitt Ulbrich, Ellen Weeks Saltzman, Catherine E. Watt Jun 2009

Options For Anderson County School Districts, 2009 June, Holley Hewitt Ulbrich, Ellen Weeks Saltzman, Catherine E. Watt

Publications

No abstract provided.

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Staff Senate Minutes, 2009 May 12, Clemson University May 2009

Staff Senate Minutes, 2009 May 12, Clemson University

Staff Senate Minutes

No abstract provided.

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Reviewed Work(S): Cumbia Callera By René Villarreal, Salvador Oropesa May 2009

Reviewed Work(S): Cumbia Callera By René Villarreal, Salvador Oropesa

Publications

No abstract provided.

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Reviewed Work(S): Hablemos De Fútbol By Víctor Hugo Morales And Roberto Alfredoperfumo; Soccer Against The Enemy. How The World's Most Popular Sport Starts And Fuelsrevolutions And Keeps Dictators In Power, Salvador Oropesa May 2009

Reviewed Work(S): Hablemos De Fútbol By Víctor Hugo Morales And Roberto Alfredoperfumo; Soccer Against The Enemy. How The World's Most Popular Sport Starts And Fuelsrevolutions And Keeps Dictators In Power, Salvador Oropesa

Publications

No abstract provided.

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Reviewed Work(S): Sólo Dios Sabe. Só Deus Sabe By Carlos Bolado, Salvador Oropesa May 2009

Reviewed Work(S): Sólo Dios Sabe. Só Deus Sabe By Carlos Bolado, Salvador Oropesa

Publications

No abstract provided.

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Clemson Commencement Program, May 2009, Clemson University May 2009

Clemson Commencement Program, May 2009, Clemson University

Clemson Commencement Programs

No abstract provided.

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Synthesis And Analysis Of Nano-Thin Polymer Films For Separation Applications, Azadeh Samadi-Dezfouli May 2009

Synthesis And Analysis Of Nano-Thin Polymer Films For Separation Applications, Azadeh Samadi-Dezfouli

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This dissertation focuses on the fabrication of uniform polymer nanolayers using surface-initiated polymerization. The kinetics of low temperature surface-initiated atom transfer radical polymerization (ATRP) is discussed in detail. The work is then extended to the surface modification of polymeric membranes to tune the physical and chemical properties of the membranes for gas separations. I discuss how atom transfer radical polymerization might be advantageous compared to some of the techniques that have been proposed in the literature for preparing polymeric membranes for CO2 separation.
The first part of this dissertation describes the synthesis of polystyrene (PS) nanolayers by surface-initiated ATRP at …

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Development Of Strategies For Enhanced In Situ Bioremediation Of High Concentrations Of Halogenated Methanes, Huifeng Shan May 2009

Development Of Strategies For Enhanced In Situ Bioremediation Of High Concentrations Of Halogenated Methanes, Huifeng Shan

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ABSTRACT
Bioremediation of high concentrations of halomethanes e.g., carbon tetrachloride (CT), trichlorofluoromethane (CFC-11) and chloroform (CF) has seldom been addressed before and remains highly challenging. A microcosm study was conducted to investigate bioremediation strategies for groundwater contaminated with CT (6 to 10 mg/L), CFC-11 (1 to 26 mg/L), CF (3-500 mg/L), and 1,1-dichloroethene (1,1-DCE; up to 9 mg/L) at a former industrial site in California. Biostimulation with corn syrup and catalytic amounts of vitamin B12 was demonstrated as a feasible remedial strategy and bioaugmentation with B12 represents the most promising bioremediation method of the ones studied. Halomethane transformation …

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Synthesis Of Ionic Liquid Monomers Using Fluorinated Sulfonyl Imide Anions And The 1,3-Dialkylimidazolium Cation, Thomas Hickman May 2009

Synthesis Of Ionic Liquid Monomers Using Fluorinated Sulfonyl Imide Anions And The 1,3-Dialkylimidazolium Cation, Thomas Hickman

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With their unique material and solvent properties, ionic liquids have seen an amazing, exponential increase in interest. After a brief introduction of select areas of interest for these compounds, this thesis mainly focuses on the development of novel polyfunctional ionic liquids and polymeric ionic liquids.
One of the preferred anions for ionic liquids is the bis((trifluoromethyl)sulfonyl) imide anion, first introduced by our group in 1982. It shows excellent thermal stability and the desired resonance delocalization of a negative charge for ionic liquids. A series of monofunctional, difunctional, and multi-functional bis(perfluoroalkylsufonyl)imides, along with 1,3-dialkylimidazolium cations were prepared by direct methylation of …

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The Animated Work Environment: A Vision For Working Life In A Digital Society, Henrique Houayek May 2009

The Animated Work Environment: A Vision For Working Life In A Digital Society, Henrique Houayek

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Dramatic transformations in the nature, place and organization of working life due to increasing sophistication and access of information technologies in the United States suggest a redesign of the work environment as a socially and technologically responsive system occupying both home and office.
This thesis examines the process of creation of an 'Animated Work Environment' [AWE]. A space in the scale of a cubicle envisioned as an environment-as-responsive-robot; an articulated, programmable interior accommodating a range of digital technologies across fluid assemblages of people working with both printed and digital materials in a variety of locations and settings, searching for a …

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Development Of An Original Laboratory Prototype For A Field Tritium Detector Containing A Pem Electrolyzer Mounted In Series With A Gas Proportional Counter, Aurelie Soreefan May 2009

Development Of An Original Laboratory Prototype For A Field Tritium Detector Containing A Pem Electrolyzer Mounted In Series With A Gas Proportional Counter, Aurelie Soreefan

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Tritium is naturally present in very small concentrations in the environment, principally in the form HTO. Thermonuclear detonations, leaks from waste tanks at the Department of Energy (DOE) sites and accidental releases from nuclear power plants have introduced significant quantities of tritium into the environment. Even though tritium is the least toxic of the known beta emitters, its presence in the environment, primarily in the aqueous form, poses a radiological threat because of its easy accessibility. Tritium removal from the environment is technologically impractical. Thus tritium contamination is generally contained, decays in place and is monitored to protect the public …

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Attachment To The Physical Age Of Urban Residential Neighborhoods: A Comparative Case Study Of Historic Charleston And I'On, Jeremy Wells May 2009

Attachment To The Physical Age Of Urban Residential Neighborhoods: A Comparative Case Study Of Historic Charleston And I'On, Jeremy Wells

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Purpose:
To counter the over-reliance of historic preservation research and practice on objective, expert values by understanding how people subjectively value and are attached to the age and design of traditionally-designed urban residential neighborhoods.
Research question:
How does the age of traditionally designed, urban residential environments affect the degree and character of place attachment for residents?
Cases:
1) historic Charleston, south of Broad Street, 2) I'On new urbanist development in Mt. Pleasant, South Carolina.
Unit of analysis:
Residents of 1) historic Charleston and 2) I'On.
Methodology (methods):
Sequential mixed-method: phenomenology (interviews) followed by a survey methodology (on-line survey instrument); both …

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Investigations Of Storm Water Management Professionals' Perceptions Of Permeable Interlocking Concrete Pavers As A Stormwater Management Option, Keith Poole May 2009

Investigations Of Storm Water Management Professionals' Perceptions Of Permeable Interlocking Concrete Pavers As A Stormwater Management Option, Keith Poole

All Dissertations

ABSTRACT
This study examined stormwater management professionals' perceptions of PICPs
(Permeable Interlocking Concrete Pavement) as a stormwater management option to
conventional curb and gutter methodology from years past.
A self-administered survey questionnaire was developed as the primary research
methodology. Three hundred stormwater management professionals were randomly
selected as research subjects, and qualitative and quantitative methods were used to
collect data for the study. Specific statistical gathering methods and tests for this study
included: ex post facto experimental design, grounded theory design, correlation
coefficients and ANOVA, and Pearson's correlation coefficients.
The survey found through quantitative analysis that although stormwater
professionals have …

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Surface And Bulk Modification Of Poly(Lactic Acid), Rahul Rasal May 2009

Surface And Bulk Modification Of Poly(Lactic Acid), Rahul Rasal

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The major drawbacks of PLA are its poor toughness and lack of readily reactable groups. Unfortunately, typical methods of PLA toughening are associated with significant modulus and/or ultimate tensile strength (UTS) loss. The main objective of this research was to toughen PLA, with minimal modulus and/or UTS loss, and introduce reactive groups into the PLA matrix in one step. Initially, this objective was divided into two separate parts: PLA surface modification followed by toughening.
PLA film was solvent cast from chloroform solution and was surface modified using a sequential two-step photografting approach. Benzophenone was photografted onto the film surface in …

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Essays In Public Choice: The Settings That Foster Increased Educational Quality, Interest Group Activity And Economic Development, Leslee Conaway May 2009

Essays In Public Choice: The Settings That Foster Increased Educational Quality, Interest Group Activity And Economic Development, Leslee Conaway

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ABSTRACT
The following essays in public choice are concerned with two main subjects: changes in public educational quality due to competition from surrounding private schools and the settings that foster increased interest group activity and what impact that activity has on the relative economic development of US states. While these subjects may seem varied, they are both important in understanding differences in economic development.
Education has long been associated with economic expansion, so it is important to understand the impacts that private markets for education have on its public provision. In Chapter II, I look at whether there are competitive …

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An Assessment Of Cognitive Level Of Instruction Presented In Animal Science Courses And The Impact On Development Of Cognition In Undergraduates, Laura White May 2009

An Assessment Of Cognitive Level Of Instruction Presented In Animal Science Courses And The Impact On Development Of Cognition In Undergraduates, Laura White

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To be successful in life, students will need to learn to make good decisions; many of them. Quality decision making is paramount for student success in future employment and their personal lives. To make a quality decision, one must weigh all possible options and understand as many of the implications of that decision as possible. Relating options and outcomes to previous experience is advantageous. The qualities mentioned above are reliant on critical thought processes. It is imperative that graduates seeking employment possess a balanced combination of base knowledge and independent thought combined with critical thinking ability. In order to produce …

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A National Survey Of Teachers On Their Perceptions, Challenges, And Uses Of Information And Communication Technology, Amy Hutchison May 2009

A National Survey Of Teachers On Their Perceptions, Challenges, And Uses Of Information And Communication Technology, Amy Hutchison

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This study had five main purposes: (a) to investigate the extent to which literacy teachers nationwide integrate information and communication technologies (ICTs) into literacy instruction; (b) to investigate the extent to which ICTs are utilized in ways that promote the acquisition of literacy skills within digital environments; (c) to identify the perceived obstacles and challenges teachers face in their attempts to integrate ICTs into instruction; (d) to determine how literacy teachers define ICT integration and how they perceive the importance of ICT integration into reading instruction; and (e) to identify the distinguishing characteristics of teachers who report no or minimal …

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Functional Interaction Of Racf2 And The Wasp Family Protein, Scar, In The Rab8 Signaling Pathway Of The Social Amoeba, Dictyostelium Discoideum, Terri Bruce May 2009

Functional Interaction Of Racf2 And The Wasp Family Protein, Scar, In The Rab8 Signaling Pathway Of The Social Amoeba, Dictyostelium Discoideum, Terri Bruce

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The small GTPase, Rab8, has been shown to play a role in cell-cell adhesion and restructuring of the actin cytoskeleton in both mammalian cells and the lower eukaryote, Dictyostelium discoideum. In D. discoideum, cells expressing constitutively activated Rab8 (Rab8CA) display reduced cell-cell adhesion and increased actin-rich protrusions as well as delayed aggregation. Rab8 has been implicated in the restructuring of the actin cytoskeleton, but no specific pathway for this action has been identified. In other systems, actin-rich membrane extension formation is regulated by WASp family proteins, including SCAR. Here we provide evidence of a functional relationship between the WASp family …

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Fundamental Aspects Of Small Molecules And Macromolecules On Poly(Ethylene Terephthalate) Capillary-Channeled Polymer Fibers, Christine Straut May 2009

Fundamental Aspects Of Small Molecules And Macromolecules On Poly(Ethylene Terephthalate) Capillary-Channeled Polymer Fibers, Christine Straut

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Stationary phases and adsorbents are continually being developed to enhance separations in high performance liquid chromatography (HPLC). Polymeric stationary phases have gained popularity due to their ability to be employed over a large pH range and because they are more chemically robust when compared to silica based phases. Capillary-channeled polymer (C-CP) fibers are an alternative to traditional porous packed bed beads. These fibers have a unique geometry with increased the surface area/volume ratios when compared to cylindrical fibers. Very unique characteristics are realized in the use of the C-CP fibers, including drastically reduced backpressures and selection of solute-surface interaction through …

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Development, Parameterization And Validation Of Dynamic Material Models For Soil And Transparent Armor Glass, Bhaskar Pandurangan May 2009

Development, Parameterization And Validation Of Dynamic Material Models For Soil And Transparent Armor Glass, Bhaskar Pandurangan

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Despite the signing of several mine ban treaties in the 1990's, it is widely recognized that there is a landmine crisis. The following are some of the main aspects of this crisis: (a) Millions of unexploded landmines remain deployed all over the world; (b) Thousands of civilians are killed or maimed every year by unintended detonations of the mines; (c) The cost of medical treatment of landmine injuries runs into the millions; (d) the ability of the international community to provide the humanitarian relief in terms of medical services, safe drinking water and food, etc., is greatly hampered by landmine …

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Rhetorical Inventions/Inventional Rhetorics: Opening Possibilities, Justin Hodgson May 2009

Rhetorical Inventions/Inventional Rhetorics: Opening Possibilities, Justin Hodgson

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This work seeks to open possibilities for rhetorical invention, or perhaps more accurately, to indicate how changes in technology (and the essences of technology) are opening radical possibilities not just for rhetorical invention but also for how we speak, how we think, or even how we live in our worlds. It traces shifts in rhetorical invention: beginning from primary oral cultures, which made linkages via a process of 'AND' or divine inspiration, represented by the +, to literate cultures (or print-cultures), which predominantly invent via analogy and discovery, represented by the =, and to electronic cultures, which revel in the …

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Constructed Wetland Treatment System: An Approach For Mitigating Risks Of Flue Gas Desulfurization Waters, Derek Eggert May 2009

Constructed Wetland Treatment System: An Approach For Mitigating Risks Of Flue Gas Desulfurization Waters, Derek Eggert

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Federal laws regarding ambient air quality are currently requiring industries to reduce emissions of sulfur dioxides (SO2). Coal-fired power plants have therefore begun implementing flue gas desulfurization (FGD) scrubbers that utilize a highly oxygenated water stream (calcium carbonate saturated water) to transform sulfur gases into soluble anion species (e.g. sulfite and sulfate). This FGD process also transfers potentially toxic constituents including arsenic, cadmium, chemical oxygen demand, copper, mercury, selenium, chloride, sulfates, and zinc into the scrubbing water. These scrubber waters, referred to as FGD waters, present an industrial problem due to the large volumes produced (378,000 to 1,900,000 L/day) and …

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The Effect Of Hydrostatic Pressure On Bladder Smooth Muscle Cell Function, Margaret Drumm May 2009

The Effect Of Hydrostatic Pressure On Bladder Smooth Muscle Cell Function, Margaret Drumm

All Theses

Previous research has demonstrated that bladder smooth muscle cells (BSMC) respond to various forms of mechanical stimuli, including stretch and hydrostatic pressure, by increases of cell proliferation, activation of intracellular signaling pathways, and alteration of contractile and synthetic marker protein expression. These cellular/molecular level changes are all indicative of a BSMC phenotypic shift that can negatively impact the bladder function at the tissue and organ level. The objective of the present study is to test a hypothesis that bladder SMCs shift their phenotype from contractile to synthetic in response to elevated hydrostatic pressure. Rat bladder SMC cultures were exposed to …

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