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Synthesis And Pharmacology Of N-Alkyl-3-(Halo-Naphthoyl)Indoles, Valerie Smith Aug 2008

Synthesis And Pharmacology Of N-Alkyl-3-(Halo-Naphthoyl)Indoles, Valerie Smith

All Dissertations

The medicinal values of marijuana have often been overshadowed due to the psychotropic, 'recreational' effects it brings about in a user. For hundreds of years the therapeutic uses of cannabis sativa were appreciated, but the inability to control the dosage of the main constituent, and therefore the psychotropic effects, rendered the drug a liability. The elucidation of the structure of this main psychoactive constituent, ∆9-tetrahydrocannabinol (∆9-THC) by Gaoni and Mechoulam in 1964 opened the door to the discovery of a vast array of knowledge about cannabinoids. From the multiple classes of cannabinoids and the ways these compounds interact with the …

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Some Problems In Statistical Mechanics With Applications To Materials Science, Ethan Ballard Aug 2008

Some Problems In Statistical Mechanics With Applications To Materials Science, Ethan Ballard

All Dissertations

In this work, some problems in statistical mechanics related to condensed matter physics and of general interst in materials science, physics, chemistry and polymer science are considered. In chapters 1-4, the work by E.M. Lifshitz on the group-theoretical refinements of the Landau theory of phase transitions is brought to completion. Based on mathematical results obtained by Yamabe, Osgood, Phillips, Sarnak, and Kholodenko analytical results for determinants were developed which allows for prediction of the symmetry of the phase after a phase transition provided that the symmetry prior to the phase transition is known. Numerical results are presented which are in …

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Vision-Based Detection, Tracking And Classification Of Vehicles Using Stable Features With Automatic Camera Calibration, Neeraj Kanhere Aug 2008

Vision-Based Detection, Tracking And Classification Of Vehicles Using Stable Features With Automatic Camera Calibration, Neeraj Kanhere

All Dissertations

A method is presented for segmenting and tracking vehicles on highways using a camera that is relatively low to the ground. At such low angles, 3D perspective effects cause significant appearance changes over time, as well as severe occlusions by vehicles in neighboring lanes. Traditional approaches to occlusion reasoning assume that the vehicles initially appear well-separated in the image, but in our sequences it is not uncommon for vehicles to enter the scene partially occluded and remain so throughout. By utilizing a 3D perspective mapping from the scene to the image, along with a plumb line projection, a subset of …

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Recombinant G3 Domain Protein Of The Rat Laminin-5 Α3 Chain Binds To Integrins On Tumorogenic Breast Cancer Cells To Induce Apoptosis, Brittany Turner Aug 2008

Recombinant G3 Domain Protein Of The Rat Laminin-5 Α3 Chain Binds To Integrins On Tumorogenic Breast Cancer Cells To Induce Apoptosis, Brittany Turner

All Dissertations

The extracellular matrix (ECM) is a network of proteins for holding tissues and cells together. Among the constituents of the ECM is the large molecular weight glycoprotein laminin. Laminin is predominately found in the basement membrane of tissues. Laminins are composed of α, β, and γ chains with 5 globular (G) subdomains at the carboxyl (C) terminal end of the α chain. Of the 12 different laminin isoforms, laminin-5 has been targeted for cancer research. Specifically, the G3 domain has been studied as the specific binding domain. Cells are able to migrate through cell surface adhesion receptors known as integrins. …

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Exploratory Synthesis Of New Open-Framework Iron (Ii,Iii)-Containing Polyanion Systems Targeted For Lithium-Ion Battery Applications, Gregory Becht Aug 2008

Exploratory Synthesis Of New Open-Framework Iron (Ii,Iii)-Containing Polyanion Systems Targeted For Lithium-Ion Battery Applications, Gregory Becht

All Dissertations

The chemistry demonstrated in this dissertation is concerned with the synthesis, structure, properties and applications of inorganic solids containing iron(II,II) redox centers. The endeavor in exploratory synthesis is due largely to the employment of molten salt fluxes such as alkali metal chloride. These halide-fluxes act in two parts; 1) as a solvent to lower the reaction temperature and 2) as an in situ source of unavailable alkali oxides through metathesis reactions. Using these halide fluxes has allowed for the discovery of several new transition metal-containing phosphates, arsenates, and vanadates for a structure/property correlation study. From this study the selected compounds …

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Effects Of Polyphenol Compounds On Iron-And Copper-Mediated Dna Damage: Mechanisms And Predictive Models, Nathan Perron Aug 2008

Effects Of Polyphenol Compounds On Iron-And Copper-Mediated Dna Damage: Mechanisms And Predictive Models, Nathan Perron

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Polyphenol compounds are widely recognized for their antioxidant activity; however, under some conditions these compounds can also exhibit prooxidant activity. This work examined the interactions of polyphenols with iron and copper to improve understanding of both their antioxidant and prooxidant effects. Polyphenols with catechol and gallol groups effectively inhibit iron-mediated oxidative DNA damage by chelating iron, with IC50 values ranging from 1-59 µM. Gallate compounds are more potent than their catecholate analogues in every instance, and their antioxidant potencies correlate to pKa values for the most acidic phenolic hydrogen. This correlation represents the first predictive model of …

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A Comprehensive Multiphysics, Multiscale Modeling Framework For Carbon Nanotube Fabrication Process By Chemical Vapor Deposition, Mahmoud Reza Hosseini Aug 2008

A Comprehensive Multiphysics, Multiscale Modeling Framework For Carbon Nanotube Fabrication Process By Chemical Vapor Deposition, Mahmoud Reza Hosseini

All Dissertations

Carbon nanotubes (CNTs) are among the most promising nanosize materials as evidenced by the attention they have received since their discovery in 1991 and a wide range of scientific and industrial applications. Each of these applications requires unique CNTs with specific length, diameter and chirality. However, control of these parameters is considered as one of the main challenges for large scale production of CNTs. Furthermore, these processes are not well designed so as to limit the number of CNT defect sites or the production of unwanted byproducts such as amorphous carbon. Therefore, it is crucial to develop a controlled CNTs …

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The Spaceflight Environment And The Skeletal System, Eric Bandstra Aug 2008

The Spaceflight Environment And The Skeletal System, Eric Bandstra

All Dissertations

The spaceflight environment presents many challenges to the human body. Bone loss in astronauts is a well known consequence of reduced loading in the weightless environment of low-earth orbit. Recent studies have also indicated that spaceflight relevant types of radiation (at relatively high doses) have deleterious effects on trabecular bone. Both of these represent potential skeletal challenges during long-duration spaceflight. The objective of these studies is to examine the response of bone to models of the spaceflight environment.
Astronauts will likely absorb doses of protons and heavy ions during lengthy missions outside the Earth's magnetosphere. Following exposure to a range …

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Functionalized Carbon Nanotubes For Biological Applications, Lingrong Gu Aug 2008

Functionalized Carbon Nanotubes For Biological Applications, Lingrong Gu

All Dissertations

Carbon nanotubes with their unique pseudo-one-dimensional nanostructures and related electronic, optical, and mechanical properties have been attracting much attention for potential biological applications, such as biosensors, bio-delivery, bioimaging and so on. In this dissertation, recent studies and advances toward bioapplications of carbon nanotubes are critically reviewed, followed by detailed reports on my research projects concerning the use of carbon nanotubes as unique scaffolds for multivalent display of sugars and the relevant results from bio-evaluation of these novel nanomaterials.
Single-walled (SWNTs) and multiple-walled carbon nanotubes (MWNTs) were functionalized with amine-derivatived monosaccharides (galactoses and mannoses) and their dendritic constructs. These sugar-functionalized carbon …

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The Role Of Metal Coordnation In The Inhibition Of Iron(Ii)- And Copper(I)-Mediated Dna Damage By Organoselenium And Organosulfur Compounds, Erin Battin Aug 2008

The Role Of Metal Coordnation In The Inhibition Of Iron(Ii)- And Copper(I)-Mediated Dna Damage By Organoselenium And Organosulfur Compounds, Erin Battin

All Dissertations

Copper and iron are two widely-studied transition metals associated with hydroxyl radical (OH) generation: Fe2+/Cu+ + H2O2 = Fe3+/Cu2+ + OH + OH-. Metal-mediated oxidative damage is a major cause of cellular DNA damage and death, and has been implicated in cancer, neurodegenerative, and cardiovascular diseases. Because sulfur and selenium antioxidants ameliorate oxidative damage, the ability of twenty biological sulfur- and selenium-containing compounds to inhibit metal-mediated DNA damage caused by hydroxyl radical has been quantified. In the Cu+/H2O2 system, six sulfur compounds and three selenium compounds inhibited DNA damage with IC50 values ranging from 3.3 to 25.5 μM. Several sulfur …

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Thermal And Structual Properties Of Candidate Moldable Glass Types, Scott Gaylord Aug 2008

Thermal And Structual Properties Of Candidate Moldable Glass Types, Scott Gaylord

All Theses

This thesis contains results of our efforts to develop a method for defining key glass material properties that must be known and modeled for the design and experimental validation of a precision glass molding (PGM) process for optical glasses. Viscosity, calorimetric, and thermal expansion properties of two commercial glass types N-BK7 and P-SK57 of SCHOTT were characterized to establish a proof-of-concept protocol for the experimental determination of meaningful material properties. Experimental results were determined in order to be incorporated into a computational model predicting final glass size and shape following a molding cycle. Experimental methods were confirmed on the two …

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Becoming A Chemist: Graduate Students' Perspectives On Chemists And Chemistry, Bethany Walls Aug 2008

Becoming A Chemist: Graduate Students' Perspectives On Chemists And Chemistry, Bethany Walls

All Theses

In order to better understand the development of chemistry graduate students throughout the research phase of their Ph.D. degrees, we conducted a study on graduate students' self-concept of being chemists. This research is motivated by our previous results that forming identities as chemists is a key step in the transformation of organic chemistry graduate students from laboratory technicians into practicing chemists. In this research study, analytical, inorganic, and physical chemistry graduate students participated in a single, semi-structured interview designed to probe how their beliefs on what it means to know and practice chemistry affect their graduate training. Results from these …

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A Spectroscopic Analysis Of Hd 134439 And Hd 134440, Yu Chen Aug 2008

A Spectroscopic Analysis Of Hd 134439 And Hd 134440, Yu Chen

All Theses

We analyze elemental abundances of the common proper motion pair HD 134439 and HD 134440 to understand their formation history. This pair of metal-poor ([Fe/H]$\sim -1.50$) halo dwarfs are known, from previous studies, to exhibit abnormally low [$\alpha$/Fe] ratios compared to typical Galactic halo stars. Some have attributed this to planetesimal accretion; others believe these stars formed in the dusty part of a dwarf spheroidal galaxy and were later captured by our Galaxy. To investigate this anomaly, we measure carbon, nitrogen, and oxygen abundances for HD 134439 and HD 134440 from near-UV molecular features using high-resolution spectra obtained with Keck …

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Overnights Encourage Girls’ Interest In Science-Related Careers, Kimberly Christman, Sara Hankemeier, Jennifer Hunter, Johnna Jennings Aug 2008

Overnights Encourage Girls’ Interest In Science-Related Careers, Kimberly Christman, Sara Hankemeier, Jennifer Hunter, Johnna Jennings

Journal of Youth Development

With sell-out crowds and phenomenal research results, Science Siesta and Advanced Science Siesta are programs designed to change the traditional perceptions that girls have about science and science-related careers. Through hands-on science activities (in and out of the lab), and through working with local female scientists, girls who range from fourth to eighth grade are provided valuable opportunities to combat the stereotype that “girls can’t do science.” This article addresses the need to engage girls in science and explains “how-to” meet that need through the Science Siesta programs.

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Clemson Commencement Program, August 2008, Clemson University Aug 2008

Clemson Commencement Program, August 2008, Clemson University

Clemson Commencement Programs

No abstract provided.

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A Novel Proof Of The Heine-Borel Theorem, Matthew Macauley, Brian Rabern, Landon Rabern Aug 2008

A Novel Proof Of The Heine-Borel Theorem, Matthew Macauley, Brian Rabern, Landon Rabern

Publications

Every beginning real analysis student learns the classic Heine-Borel theorem, that the interval [0,1] is compact. In this article, we present a proof of this result that doesn't involve the standard techniques such as constructing a sequence and appealing to the completeness of the reals. We put a metric on the space of infinite binary sequences and prove that compactness of this space follows from a simple combinatorial lemma. The Heine-Borel theorem is an immediate corollary.

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The Effects Of Singing And Chanting On The Reading Achievement And Attitudes Of First-Graders, Kathy Cochran Aug 2008

The Effects Of Singing And Chanting On The Reading Achievement And Attitudes Of First-Graders, Kathy Cochran

All Dissertations

This research involves a mixed-methods case study of the reading instruction in a first grade class taught by Ms. Bing, a veteran of 29 years of first grade teaching. Analyses of classroom field notes and interviews of Ms. Bing provided insights into her methods of teaching reading, which focus largely on the use of song lyrics and chants instead of basal text. Occurring predominantly during the first semester of the school year, the study involved observations of reading instruction given to Ms. Bing's class, which initially numbered 23 students. While the school required all first grade teachers to employ Cunningham's …

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Spatial Variability Of Radionuclide Distribution Coefficients At The Savannah River Site And The Sub-Surface Transport Implications, Kelly Grogan Aug 2008

Spatial Variability Of Radionuclide Distribution Coefficients At The Savannah River Site And The Sub-Surface Transport Implications, Kelly Grogan

All Theses

Distribution coefficients, Kd, were measured for a suite of gamma-emitting radionuclides in uncontaminated soils from the E-Area burial grounds at the Savannah River Site. The objectives of the study were to (1) characterize the spatial variability of Kd, (2) evaluate the effect of spatial variability on vadose zone transport, and (3) develop statistical models for predicting Kd from physical or chemical characteristics.
Equilibrium batch sorption tests were performed on 27 soil samples collected from depths ranging from 11 ft to 100 ft from the BGO-3A core with 241Am, 109Cd, 139Ce, 137Cs, 57Co, 60Co, 203Hg, 85Sr, and 88Y. Distribution coefficients were …

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A Comparison Of Sequential And Integrated Data Fusion For Estimating Hydrologic Properties During A Synthetic Gpr Monitored Infiltration Event, Guy Sicilia Jr Aug 2008

A Comparison Of Sequential And Integrated Data Fusion For Estimating Hydrologic Properties During A Synthetic Gpr Monitored Infiltration Event, Guy Sicilia Jr

All Theses

Constraining parameters that govern variably saturated flow is important for applications ranging from quantifying water availability for ecosystems to constraining recharge rates and contaminant fluxes to groundwater. In this study I explore the effectiveness of sequential versus integrated data fusion for estimating unsaturated flow parameters using ground penetrating radar (GPR) data. In Sequential Data Fusion (SDF), geophysical imaging is used to create a map of the geophysical properties of the subsurface. These properties are then transformed to hydrologic properties that can be used to constrain an independent hydrologic inverse problem. In contrast, Integrated Data Fusion (IDF) uses the geophysical data …

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Stereotype Threat And Women's Perceptions Of Leadership Self-Efficacy, Phillip Lipka Aug 2008

Stereotype Threat And Women's Perceptions Of Leadership Self-Efficacy, Phillip Lipka

All Theses

The following research examined the effects of stereotype threat on women's leadership self-efficacy. Previous research has demonstrated that women's leadership aspirations are negatively affected by the presence of stereotype threat, and the current research served to expand on this literature by examining possible factors that could moderate women's vulnerability to this threat. It was proposed that women with a weaker adherence to sexist beliefs, less investment in gender ideals, and higher self-esteem would be less susceptible to stereotype threat and would perceive themselves as more capable leaders. Participants completed a survey that primed their gender identity in order to invoke …

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Analysis Of The Nonlinear Vibrations Of Electrostatically Actuated Micro-Cantilevers In Harmonic Detection Of Resonance (Hdr), Jonathan Taylor Jul 2008

Analysis Of The Nonlinear Vibrations Of Electrostatically Actuated Micro-Cantilevers In Harmonic Detection Of Resonance (Hdr), Jonathan Taylor

All Theses

Micro- and nano-cantilevers have the potential to revolutionize physical, chemical, and biological sensing; however, an accurate and scalable detection method is required. In this work, a fully electrical actuation and detection method is presented, known as the Harmonic Detection of Resonance (HDR). In HDR, harmonic components of the current are measured to determine the cantilever's resonance frequency. These harmonics exist as a result of nonlinearities in the system, principally in the electrostatic actuation force. In order to better understand this rich harmonic structure, a theoretical investigation of the micro-cantilever is undertaken. Both a lumped parameter model and a more accurate …

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Assessment Of Potential Site Selection Methods For Use In Prioritizing Safety Improvements On Georgia Roadways, Priyanka Alluri Jul 2008

Assessment Of Potential Site Selection Methods For Use In Prioritizing Safety Improvements On Georgia Roadways, Priyanka Alluri

All Theses

With over 40,000 people continuing to die on US roads each year, the US government has heightened the awareness of critical safety issues with the passage of SAFETEA - LU legislation in 2005. The plan requires each of the states to develop a Strategic Highway Safety Plan (SHSP) and incorporate data-driven approaches to prioritize and evaluate program outcomes; else federal funds will be redirected. Seeking to meet the new demands for data-driven approaches, many states are struggling to identify data collection/maintenance requirements for satisfying new approaches to highway safety analysis. Recent research has shown that selecting projects on the basis …

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A Regularization Technique For The Analysis Of Photographic Data Used In Chemical Release Wind Measurements, Justin Ingersoll Jul 2008

A Regularization Technique For The Analysis Of Photographic Data Used In Chemical Release Wind Measurements, Justin Ingersoll

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The neutral winds are a key parameter in the electrodynamics of the ionosphere. The available techniques for measuring vertical neutral wind profiles, especially with good height resolution, are extremely limited. This is especially true with sounding rocket flights as it is not practical to take direct measurements of neutral winds with onboard instruments. Chemical releases from sounding rockets, however, allow such measurements by providing a tracer of the motion of the neutral atmosphere at altitudes in the mesosphere and lower thermosphere (MLT). The resulting chemiluminescent trail is typically photographed from two or more locations to track neutral motions. Triangulation based …

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Quantitative Modeling Of Soil Properties Based On Composition And Application To Dynamic Tire Testing, Sumalatha Yaski Jul 2008

Quantitative Modeling Of Soil Properties Based On Composition And Application To Dynamic Tire Testing, Sumalatha Yaski

All Theses

A new dimension of success in automotive supply is time-based competition. This especially comes to light in tire development, with companies striving to enhance the testing methodologies for reduction in development time. Modeling and development of off-road tires is particularly difficult due to a lack of quantitative descriptions of the operating environment for model validation. Off-road tire evaluation is subjective, expensive, site dependent, and testing of such tires is typically carried out under lower levels of control. The objective of this work is to create fundamental descriptions of pertinent composition based soil properties and to directly relate these properties to …

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Reduction Of Sink Marks In Wire Insert Molded Parts, Gauri Phadke Jul 2008

Reduction Of Sink Marks In Wire Insert Molded Parts, Gauri Phadke

All Theses

Integrating the huge wiring harness network with the plastic trim components found in the car is an attractive way to reduce the vehicle weight. When any foreign object is inserted in an injection molded part, the change in polymer cross section leads to sink marks which are aesthetic defects and are not acceptable for plastic trim components.
In this thesis, a method to minimize or eliminate sink marks for wire insert molded component using injection molding process is presented. L9 Taguchi DOE experimental framework has been employed to study the effect of process parameters, part rib geometry, and the presence …

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Assessment Of Fifth Metatarsal Etiology, Daniel Reed Jul 2008

Assessment Of Fifth Metatarsal Etiology, Daniel Reed

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The fifth metatarsal 'Jones Fracture' is a fracture that occurs 3.5cm distal to the tuberosity. It is an injury that is common in athletes, especially those who participate in sports with a lot of lateral movement. The Jones Fracture is known for its difficulty to heal due to non-union and re-fracture. There has been much research recently regarding in-shoe pressure distributions and their relation to shoe type, movement, and shoe surface interaction. However, only the forces along the bottom of the foot have been investigated. Literature and the direction of fracture seem to implicate a force on the lateral portion …

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The Design Of A Data Recorder To Test The Effects Of Color Contrast On 'This Side Up' Pictorial Markings On Package Orientation Within Ups Ground, Rupert Hurley Jul 2008

The Design Of A Data Recorder To Test The Effects Of Color Contrast On 'This Side Up' Pictorial Markings On Package Orientation Within Ups Ground, Rupert Hurley

All Theses

A data recorder was built and qualified to record package orientation over time. The device was then used to observe the effects on package orientation during UPS ground shipping of current and modified ASTM D5445-03 'This Side Up' symbols. Modified symbols on packages demonstrated the effects of contrasting color relationships on symbol noticeability and human compliance. Shipping trials were conducted through UPS distribution centers for cube-shaped packages equipped with custom designed tri-axial accelerometers. Data recorded on 112 shipments provide comparisons of four ASTM D5445-03 'This Side Up' symbols: unmodified, modified blue, modified 'black and white', and control (no symbol). Data …

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Thermal Coulomb Drag In A Bi-Layer Semiconductor System, Florin Lung Jul 2008

Thermal Coulomb Drag In A Bi-Layer Semiconductor System, Florin Lung

All Theses

In this work, we investigate the existence of a thermoelectric effect that consists of the appearance of an electric field in one layer when a temperature gradient is applied in the other layer of a double quantum well system. This represents a generalization of the Seebeck effect to the case of two spatially separated electron systems allowed to interact only through the Coulomb repulsion. The induced electric field results from the momentum transfer between the electrons driven out of equilibrium by the temperature gradient and the electrons at rest in the passive layer, a mechanism known in the literature as …

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Three Design Tool Focused Case Studies Of Mechanical Engineering Design Projects, William Miller Jul 2008

Three Design Tool Focused Case Studies Of Mechanical Engineering Design Projects, William Miller

All Theses

Three long term mechanical engineering design projects spanning 24 months, 12 months, and 4 months are examined in this thesis. These projects are used to explore the development of a way to represent information flow throughout the design process with respect to design tools used. This is a first step in a broader effort to formalize 1) modeling of design processes, 2) establishing case study research as a formal approach to design research, and 3) developing new design process tools.
A survey of existing models compares the differences between current approaches and the limitations of each. Inspired by IDEF0, an …

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Enhancement Of Information Management Capabilities In Mdo Framework, Santosh Hiriyannaiah Jul 2008

Enhancement Of Information Management Capabilities In Mdo Framework, Santosh Hiriyannaiah

All Theses

Multidisciplinary Design Optimization (MDO) frameworks have been developed to facilitate the integration of disciplinary analysis codes and optimization techniques. Recent advances in MDO frameworks have addressed issues related to data exchange, distributed computing, process integration and trade study. However, managing, storing and sharing MDO problem information have not yet been fully addressed. In this research a software configuration is proposed. The configuration is built upon a structured repository, common file system and software applications. The configuration is integrated into a commercially available MDO framework to manage, store and share MDO problem information. A common file system proposed in this research …

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