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Real-Time Observation Of Dynamic Sarcomeric Addition In An In Vivo-Like Cardiomyocyte Culture Model, Zhonghai Wang Aug 2017

Real-Time Observation Of Dynamic Sarcomeric Addition In An In Vivo-Like Cardiomyocyte Culture Model, Zhonghai Wang

All Dissertations

Cardiac hypertrophy is the enlargement of individual cardiac muscle cell (cardiomyocyte) in both size and mass, which is achieved by addition of sarcomeres, the basic contractile unit. Cardiomyocytes elongate by adding sarcomeres in series and thicken by adding sarcomeres in parallel. Though it is generally accepted that sarcomeric addition can be initiated by increased mechanical loading, the sarcomeric addition process under various mechanical overloads on molecular level remains largely unknown. Previous research on sarcomeric addition largely rely on animal models of induced cardiac hypertrophy; those experiments provide little direct evidence for sarcomeric addition process as a response to increased mechanical …

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Survival, Recovery, And Inactivation Of Human Norovirus Surrogates, Feline Calicivirus And Murine Norovirus, On Carpets, David Buckley Aug 2017

Survival, Recovery, And Inactivation Of Human Norovirus Surrogates, Feline Calicivirus And Murine Norovirus, On Carpets, David Buckley

All Dissertations

Worldwide, enteric viruses are the main cause of acute gastroenteritis (AGE). Among these viruses, human noroviruses (HuNoV) are leading cause of AGE and account for ca. 20% of all diarrheal cases, a top-five cause of death worldwide. In humans, these viruses spread via person-to-person contact, food, water, and/or the environment. Person-to-person contact is the most common mode of HuNoV transmission. Yet, environmental transmission has been linked to several outbreaks and prolonged others. HuNoV survival and inactivation on hard environmental surfaces have been extensively studied. However, nonlaunderable soft surfaces, such as carpet, have received little attention despite epidemiological evidence suggesting their …

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Proteinaceous Resin And Hydrophilic Encapsulation: A Self-Healing-Related Study, Ting Zheng Aug 2017

Proteinaceous Resin And Hydrophilic Encapsulation: A Self-Healing-Related Study, Ting Zheng

All Dissertations

Inspired by living organisms, self-healing materials have been designed as smart materials. Their automatic healing nature is achieved through the use of capsule in which the healing agent is encapsulated. The occurrence of cracks leads to ripping of the capsule, along with crack propagation and release of the healing agent that wets the crack surface to eventually heal (bond) the crack. Such automatic repair of the crack significantly extends the service life of the material. A vast majority of existing self-healing systems have been designed for the epoxy matrix - the most common commercially used thermoset - that possesses low …

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Latent Data Modeling With Biostatistical Applications, Yan Liu Aug 2017

Latent Data Modeling With Biostatistical Applications, Yan Liu

All Dissertations

This dissertation consists of three projects that make use of latent variable modeling techniques. One of the focuses of this dissertation research has been in the area of spatial and spatio-temporal modeling. The specific topics and motivating problems in this study have been fully supported and motivated by the Companion Animal Parasite Council (CAPC). In particular, the CAPC has developed a rather extensive database, which houses several common dog disease data sets collected throughout the conterminous United States. This data exists at a county level and was collected monthly over a span of 5 consecutive years, and exhibits strong spatial …

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Quickly, Archy, And The Citizens’ Wives; Or, How To Talk To An Elephant, Barbara Sebek Jul 2017

Quickly, Archy, And The Citizens’ Wives; Or, How To Talk To An Elephant, Barbara Sebek

Early Modern Culture

No abstract provided.

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Phylogenetic Signals In Detoxification Pathways In Cyprinid And Centrarchid Species In Relation To Sensitivity To Environmental Pollutants, Peter Van Den Hurk, Lindsay E. Gerzel, Peter Calomiris, Dennis C. Haney Jul 2017

Phylogenetic Signals In Detoxification Pathways In Cyprinid And Centrarchid Species In Relation To Sensitivity To Environmental Pollutants, Peter Van Den Hurk, Lindsay E. Gerzel, Peter Calomiris, Dennis C. Haney

Publications

Observations in a previous study on biomarker responses in fish collected from urban creeks in Greenville, SC, indicated that there might be considerable differences in the expression of biotransformation enzymes in chub and sunfish species. To further investigate these species differences a dosing experiment was performed in which bluehead and creek chub (Nocomis leptocephalus and Semotilus atromaculatus), and redbreast sunfish, pumpkinseed, and bluegill (Lepomis auritus, L. gibbosus, and L. macrochirus) were injected with benzo[a]pyrene (BaP) as a model compound for common pollutants in urban creeks. Fish were injected with BaP doses of 0, 25 and 50 mg/kg, …

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In-Stream Habitat Predicts Salamander Occupancy And Abundance Better Than Landscape-Scale Factors Within Exurban Watersheds In A Global Diversity Hotspot, Nathaniel Weaver, Kyle Barrett Jul 2017

In-Stream Habitat Predicts Salamander Occupancy And Abundance Better Than Landscape-Scale Factors Within Exurban Watersheds In A Global Diversity Hotspot, Nathaniel Weaver, Kyle Barrett

Publications

The southern Appalachian Mountains have experienced rapid human population growth rates since the 1980s. Land used practices are shifting from rural to residential. The majority of development has been low density, and is often near biologically diverse areas such as National Forests and National Parks. The long-term effects of urbanization in the southeastern Appalachian Mountains are not clearly understood and even less is known with respect to stream salamander response to urbanization. In order to determine the temporal influence of exurban housing on southern Appalachian streams we sampled 27 first- and second-order streams in watersheds containing exurban developments ranging in …

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Assessment Of Anemia Levels In Infants And Children In High Altitude Peru, Roxanne Amerson, Lisa Miller, Michelle Glatt, Jenna Baker Jul 2017

Assessment Of Anemia Levels In Infants And Children In High Altitude Peru, Roxanne Amerson, Lisa Miller, Michelle Glatt, Jenna Baker

Publications

When prevalence rates of anemia exceed 40%, the World Health Organization recognizes this as a severe public health problem. In Peru, approximately 43.5% (urban) and 51.1% (rural) of children between the ages of 6 and 36 months have anemia. Currently, limited data exists regarding prevalence rates in many of the high altitude regions of Peru. The main purpose of this pilot study was to establish evidence of anemia in infants and children (7 months through 5 years of age) living in the rural, mountainous region of Ollantaytambo District. This pilot study utilized a quantitative, cross-sectional design to assess the presence …

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Queer Philologies: Sex, Language, And Affect In Shakespeare's Time / Jeffrey Masten, Andy Kesson Jun 2017

Queer Philologies: Sex, Language, And Affect In Shakespeare's Time / Jeffrey Masten, Andy Kesson

Early Modern Culture

No abstract provided.

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Posthuman Lear: Reading Shakespeare In The Anthropocene / Craig Dionne, Karen Raber Jun 2017

Posthuman Lear: Reading Shakespeare In The Anthropocene / Craig Dionne, Karen Raber

Early Modern Culture

No abstract provided.

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The Influence Of Exurban Landscapes And Local Site Characteristics On Riparian Vegetation, Nathan Weaver, Kyle Barrett, Don L. Hagan Jun 2017

The Influence Of Exurban Landscapes And Local Site Characteristics On Riparian Vegetation, Nathan Weaver, Kyle Barrett, Don L. Hagan

Publications

The southern Appalachian Mountains have experienced large population growth and a change in land use in the past 30 years. The majority of development has been low density, suburban land, known as exurban development. The long-term effects of exurbanization on riparian vegetative communities in the southeastern Appalachian Mountains are not well known. We sought to determine if vegetative community composition and structure change as a function of watershed–level variables such as time since neighborhood development or percent impervious surface within the watershed. We also assessed local–scale measures of disturbance such as canopy cover and basal area. Over two years we …

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Cancer Cell Redirection Biomarker Discovery Using A Mutual Information Approach, Kimberly Roche, F. Alex Feltus, Jang Pyo Park, Marie-May Coissieux, Chenyan Chang, Vera B.S. Chan, Mohamed Bentires-Alj, Brian W. Booth Jun 2017

Cancer Cell Redirection Biomarker Discovery Using A Mutual Information Approach, Kimberly Roche, F. Alex Feltus, Jang Pyo Park, Marie-May Coissieux, Chenyan Chang, Vera B.S. Chan, Mohamed Bentires-Alj, Brian W. Booth

Publications

Introducing tumor-derived cells into normal mammary stem cell niches at a sufficiently high ratio of normal to tumorous cells causes those tumor cells to undergo a change to normal mammary phenotype and yield normal mammary progeny. This phenomenon has been termed cancer cell redirection. We have developed an in vitro model that mimics in vivo redirection of cancer cells by the normal mammary microenvironment. Using the RNA profiling data from this cellular model, we examined high-level characteristics of the normal, redirected, and tumor transcriptomes and found the global expression profiles clearly distinguish the three expression states. To identify potential redirection …

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Cancer Cell Redirection Biomarker Discovery Using A Mutual Information Approach, Kimberly Roche, F. Alex Feltus, Jang Pyo Park, Marie-May Coissieux, Chenyan Chang, Vera B.S. Chan, Mohamed Bentires-Alj, Brian W. Booth Jun 2017

Cancer Cell Redirection Biomarker Discovery Using A Mutual Information Approach, Kimberly Roche, F. Alex Feltus, Jang Pyo Park, Marie-May Coissieux, Chenyan Chang, Vera B.S. Chan, Mohamed Bentires-Alj, Brian W. Booth

Publications

Introducing tumor-derived cells into normal mammary stem cell niches at a sufficiently high ratio of normal to tumorous cells causes those tumor cells to undergo a change to normal mammary phenotype and yield normal mammary progeny. This phenomenon has been termed cancer cell redirection. We have developed an in vitro model that mimics in vivo redirection of cancer cells by the normal mammary microenvironment. Using the RNA profiling data from this cellular model, we examined high-level characteristics of the normal, redirected, and tumor transcriptomes and found the global expression profiles clearly distinguish the three expression states. To identify potential redirection …

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Exchange Of Polar Lipids From Adults To Neonates In Daphnia Magna: Perturbations In Sphingomyelin Allocation By Dietary Lipids And Environmental Toxicants, Namrata Sengupta, Delaney C. Reardon, Patrick D. Gerard, William S. Baldwin May 2017

Exchange Of Polar Lipids From Adults To Neonates In Daphnia Magna: Perturbations In Sphingomyelin Allocation By Dietary Lipids And Environmental Toxicants, Namrata Sengupta, Delaney C. Reardon, Patrick D. Gerard, William S. Baldwin

Publications

Because xenosensing nuclear receptors are also lipid sensors that regulate lipid allocation, we hypothesized that toxicant-induced modulation of HR96 activity would alter lipid profiles and the balance between adult survival and neonate production following exposure in Daphnia magna. Adult daphnids were exposed to unsaturated fatty acid- and toxicant- activators or inhibitors of HR96 and later starved to test whether chemical exposure altered allocation toward survival or reproduction. The HR96 activators, linoleic acid and atrazine, decreased reproduction as expected with concomitant changes in the expression of HR96 regulated genes such as magro. The HR96 inhibitors, docosahexaenoic acid (DHA) and triclosan, …

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Avs Corner, May 2017, Peyton Voirin, Leslie Wood, Kim Hill, Johanna Johnson, Annie Kate Herlong May 2017

Avs Corner, May 2017, Peyton Voirin, Leslie Wood, Kim Hill, Johanna Johnson, Annie Kate Herlong

AVS Corner

No abstract provided.

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Biochemical Effects Of Pollutant Exposure In Fish From Urban Creeks In Greenville, Sc (Usa), Peter Van Den Hurk, Dennis C. Haney May 2017

Biochemical Effects Of Pollutant Exposure In Fish From Urban Creeks In Greenville, Sc (Usa), Peter Van Den Hurk, Dennis C. Haney

Publications

The city of Greenville, SC is a rapidly expanding urban area located on the Reedy River in the upstate of South Carolina. Historical and current point-source pollutants and runoff from impermeable surfaces have resulted in a contaminated river environment, which through previous studies was demonstrated to be reflected in biological effects in fish species in the river. Because it was not known how much smaller tributaries in the urbanized area were contributing to the pollution of the main stem of the Reedy River, we collected fish (bluehead chub (Nocomis leptocephalus), creek chub (Semotilus atromaculatus), bluegill ( …

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Blockbusters: Films And The Books About Them Display, Maggie Mason Smith May 2017

Blockbusters: Films And The Books About Them Display, Maggie Mason Smith

Presentations

The Summer Blockbuster Season has started! Along with some great films, our new display features books about the making of blockbusters and their cultural impact as well as books on famous blockbuster directors Spielberg, Lucas, and Cameron. Come by Cooper throughout the month of May to check out the Star Wars series and Star Wars Propaganda; Jaws and Just When you thought it was Safe: A Jaws Companion; The Dark Knight trilogy and Hunting the Dark Knight; plus much more!

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Alterations Of Disinfection Byproduct Formation Following Exposures Of Algae To Wildfire Ash Solutions And Copper Algaecide, Kuo-Pei Tsai May 2017

Alterations Of Disinfection Byproduct Formation Following Exposures Of Algae To Wildfire Ash Solutions And Copper Algaecide, Kuo-Pei Tsai

All Dissertations

No abstract provided.

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Connector Or Disconnector: Analyzing Impacts Of The Interstate 75/85 Connector On Historic Neighborhoods In Atlanta, Georgia, Caroline Darnell May 2017

Connector Or Disconnector: Analyzing Impacts Of The Interstate 75/85 Connector On Historic Neighborhoods In Atlanta, Georgia, Caroline Darnell

All Theses

As a response to growing traffic in Atlanta, almost constant road work has been occurring in the city for the past 75 years. The growth of the city and the ever-changing road system has had dramatic impact on the physical deterioration of the historic fabric of the city. One of the most intense impacts came with the construction and reconstruction of the Interstate 75/85 Connector running north to south through the center of downtown. This research examines impacts of the construction of the interstate in the 1950s and the reconstruction in the 1980s to determine the level of physical deterioration …

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Novel Device For Improved Diagnosis And Monitoring Of Rotator Cuff Injury, Brittany Nicole Hall May 2017

Novel Device For Improved Diagnosis And Monitoring Of Rotator Cuff Injury, Brittany Nicole Hall

All Theses

Rotator cuff disease impacts approximately over 50% of the population above the age of 60, causing pain and ultimately possible loss of shoulder function. The rotator cuff is composed of muscles and tendons that work in tandem to support the shoulder and aid in the movement of the arm. History of trauma and increased age can lead to a rotator cuff tear, which can range in severity from a partial-thickness tear to a full-thickness, total rupture. Currently, diagnostic techniques for rotator cuff disease are based on physical assessment, detailed patient history, and medical imaging, primarily X-ray, MRI and ultrasonography. However, …

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Framework For Embedding Physical Systems Into Virtual Experiences, Saurabh Hindlekar May 2017

Framework For Embedding Physical Systems Into Virtual Experiences, Saurabh Hindlekar

All Theses

We present an immersive Virtual Reality (VR) experience through a combination of technologies including a physical rig; a gamelike experience; and a refined physics model with control. At its heart, the core technology introduces the concept of a physics-based communication that allows force-driven interaction to be shared between the player and game entities in the virtual world. Because the framework is generic and extendable, the application supports a myriad of interaction modes, constrained only by the limitations of the physical rig (see Figure 1). To showcase the technology, we demonstrate a locomoting robot placed in an immersive gamelike setting.

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The Influence Of Sociodemographic, Location, And Health Characteristics On Environmental Risk Perception, Alicia Michel Scalia May 2017

The Influence Of Sociodemographic, Location, And Health Characteristics On Environmental Risk Perception, Alicia Michel Scalia

All Theses

Environmental risk perception is how much risk people perceive as existing due to environmental hazards. This is a topic relevant to our time, a time of environmental policy shifts and concern about pollution, and is an important concept for policy makers to understand. This study explored the following questions: Do sociodemographic characteristics, such as gender, race, age and education, influence environmental risk perception? Do location characteristics, such as if the area surrounding the home is polluted or not, and length of residence, influence environmental risk perception? And finally, do health characteristics, both self-rated health and diagnosed conditions, influence environmental risk …

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Effects Of Phosphorus Concentration On Algal Composition And Bioprocessing Potential, Cassidy Laird May 2017

Effects Of Phosphorus Concentration On Algal Composition And Bioprocessing Potential, Cassidy Laird

All Theses

As an increasing amount of carbon dioxide (CO2) and other greenhouse gases pollute the lower atmosphere, and as various chemicals and elements pollute the water and soil, many search for potential solutions. One possibility is bio-mitigation using algae. Algae use CO2 and common polluting nutrients like nitrogen and phosphorus to grow. The growth, in turn, produces biomass and other byproducts that are converted to commodities such as biofuels, pharmaceuticals, cosmetics, and food supplements. Cosmetics and gelatin products are commonly sold, while other chemical products have bottlenecks in the process that require further research to make it marketable. The potential bioproducts …

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Target-Specific Capture Of Relevant Gaseous Compounds Using Natural And Synthetic Nano And Micro Materials, Fernanda Delbuque Guerra May 2017

Target-Specific Capture Of Relevant Gaseous Compounds Using Natural And Synthetic Nano And Micro Materials, Fernanda Delbuque Guerra

All Dissertations

By definition, volatile organic compounds (VOCs) are organic compounds that easily become vapor or gases. Many VOCs are hazardous air pollutants and often known for their low, often unpleasant, threshold odor, which can be below parts per billion in some cases. Nanotechnology-based materials for the remediation of gaseous pollutants has been the focus of many researchers due to their unique chemical and physical properties and enhanced reactivity when compared to bulkier materials. Among the many challenges preventing the global use of nanomaterials are the high costs of fabrication, on-site recovery, limited scale-up, potential toxicity since many of them rely on …

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Acetate Transport Is Essential For Survival And Virulence Of Cryptococcus Neoformans, Grace Naanyu Kisirkoi May 2017

Acetate Transport Is Essential For Survival And Virulence Of Cryptococcus Neoformans, Grace Naanyu Kisirkoi

All Dissertations

Cryptococcus neoformans is a basidiomycetous fungal pathogen that claims 625,000 lives annually worldwide. Particularly among the immunocompromised, it is the leading cause of fungal meningitis following pulmonary colonization and dissemination to the central nervous system via the blood-brain barrier. The success of C. neoformans as a pathogen is largely attributable to metabolic scavenging during starvation conditions within the host's environment. Lung alveolar macrophages, which are among the first immune effectors to combat an initial pulmonary infection, present a glucose- and amino acid-poor environment that likely necessitates metabolism of nonpreferred carbon sources such as lactate and acetate for establishment of a …

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Toxicity Of Microplastics To Aquatic Organisms, Sarah Au May 2017

Toxicity Of Microplastics To Aquatic Organisms, Sarah Au

All Dissertations

Plastic is used in products that span from cutlery to the main components in automobiles, and airplanes. Both municipal solid waste streams and marine debris are comprised of largely plastic products, and as annual global plastic production and use is unlikely to decrease, the presence of plastic in the environment will likely increase. Microplastics (MPs) are plastic fragments that have at least one dimension that is less than 5 mm, and have been found throughout water bodies around the world. MPs are in the same size fraction as most sediment particles and microorganisms, allowing them to be easily ingested by …

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Development Of A Tissue Engineered Mitral Valve, Christopher Patrick Deborde May 2017

Development Of A Tissue Engineered Mitral Valve, Christopher Patrick Deborde

All Dissertations

Heart valve diseases affect nearly 8 million people every year in the United States. Of these patients, 72% are affected by mitral valve diseases. Stenosis, regurgitation, and prolapse of the mitral valve are the primary pathologies affecting valve function resulting in atrial fibrillation, arterial thromboembolism, pulmonary edema, pulmonary hypertension, cardiac hypertrophy and heart failure. Surgical options to repair or replace the mitral valve are only palliative, especially for children with congenital defects, and do not exclude the need for reoperation. A tissue-engineered option is feasible and holds great potential through the combination of decellularized scaffolds, patient stem cells, and heart …

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Procedural Spanish Moss Renderman Shader, Summer O'Neal Benton May 2017

Procedural Spanish Moss Renderman Shader, Summer O'Neal Benton

All Theses

This thesis discusses the creation of computer generated photorealistic Spanish moss, a plant that grows in trees in the American Southeast. In order to replicate the plant, a Renderman procedural shader was used that included hair-like qualities in order to replicate the surface properties of Spanish moss. The necessary attributes, how they are used in the code, and final results of the shader applied to a moss model are included in this paper.

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Abducted By Reading Machines: Pragmatism And The Discourse Of Distant Reading, Matthew Scott Duncan May 2017

Abducted By Reading Machines: Pragmatism And The Discourse Of Distant Reading, Matthew Scott Duncan

All Theses

This project begins with an investigation of a case study in literary analysis that attempts to bring together close and distant reading techniques to enhance the output of both methods. The investigation reveals not only a breakdown in the attempted corroboration of truth claims and evidence across methods, but a tension felt more broadly in the discourse surrounding distant reading as a methodological and disciplinary position. In response to this problematic, I access C.S. Peirce and John Dewey to construct an argument for a pragmatic model for mediating between the more traditional methods employed in literary studies and the computational …

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A Shared Resilience In Contemporary Southern Literature: Dorothy Allison's Bastard Out Of Carolina And Robin Boylorn's Sweetwater: Black Women And Tales Of Resilience, Laurie Pfister Epps May 2017

A Shared Resilience In Contemporary Southern Literature: Dorothy Allison's Bastard Out Of Carolina And Robin Boylorn's Sweetwater: Black Women And Tales Of Resilience, Laurie Pfister Epps

All Theses

As literary scholars, Southern Literature as we know it today needs to be all-inclusive of its people - all genders and all races. The South offers a most unique blend of colorful people that share a deep scar of a past full of injustices; however, it is through the richness in women writers' descriptions of the South and phenomenal characters with very realistic lives and circumstances that we can recognize many similarities of resilience and struggles with that identity and its daily attributes. In exploring the idea of a intercultural or intersection of Southern women and their lives, I want …

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