Digital Commons Network^™

A Novel Therapeutic Strategy For Alzheimer’S Disease: Sex-Dependent Mechanisms Altered By The Hdac Inhibitor Rg2833 In A Transgenic Rat Model, Kelechi Ndukwe

Dissertations, Theses, and Capstone Projects

Alzheimer’s disease (AD) is the most common cause of dementia. In the United States, AD affects about 6.2 million Americans and is projected to reach 13.8 million by 2050. Currently, there are no effective therapies for AD and therapies targeting epigenetic mechanisms have shown to be effective in improving cognitive performance in animal models of AD. However, until now no study has reported sex-dependent mechanisms leading to differential expression of genes that contribute to changes in AD pathology. From our in silico studies, we identified an FDA-approved drug, RG2833 (N-[6-(2-aminoanilino)-6-oxohexyl]-4-methylbenzamide) that penetrates the blood brain barrier and can potentially ameliorate …

Cartographic Subjectivity In Fernand Deligny’S Lignes D’Erre, Anya Komar

Dissertations, Theses, and Capstone Projects

Fernand Deligny (1913-1996) was a French thinker, writer, and social worker who dedicated his entire life to an abolitionist project of protecting “severely autistic” children from internment in mental asylums by allowing them to move freely through the mountains of Cévennes where he established a support network for neurodiverse children. He privileged children’s nonverbal state and let them “direct” the community.

This thesis aims to historicize the drawings made under the guidance of Fernand Deligny between the 1960s and 1980s. His drawing method of tracing children’s movement offered an unprecedented way of providing visibility to children with nonverbal autism, outside …

Bow Articulations In The Late Galant (1775–1812): An Analysis Of Bow Strokes In Selected Violin Sonatas Of Mozart And Beethoven, Julia E. Danitz

Dissertations, Theses, and Capstone Projects

This study examines the evolving use of the violin bow during the late galant and Classical era (1776-1812) by means of several violin sonatas by Wolfgang Amadeus Mozart and Ludwig van Beethoven (K. 305, K. 454. Op. 12, No. 1, Op. 96). An analysis of bow articulations supplemented with annotated music examples is provided for these works, as well as information on the bow innovations and French violin school pedagogy at the turn of the 19th century. Understanding the style of bowing during the late 18th century and turn of the 19th century can help inform a modern performer of …

Typologies Of Battering: Uncovering Patterns Of Coercive Tactics Used By Abusive Men In A Mixed Methods Study, Abbie L. Tuller

Dissertations, Theses, and Capstone Projects

Coercive control provides a current day feminist understanding of intimate partner violence (IPV). Recent research has demonstrated the significance of coercive control and suggests it provides a more accurate understanding of IPV than using physical violence alone. Utilizing a feminist lens, this study’s first aim was to explore if typologies based on coercive control could be developed. The second and third aims were to explore if demographic differences and differences in masculinity exist across typologies. The final aim of this study was to continue the feminist understanding of IPV using the moral emotions of shame and guilt as an extension …

Electrophysiological Signatures Of Stress Adaptability In The Bnst-Vta Pathway, Yuka Miura

Dissertations, Theses, and Capstone Projects

Chronic stress has detrimental effects on psychological and physiological health. Incapability to adapt to chronic stress can lead to depression, anxiety disorders, and addiction. The brain regions critical for reward processing share diverse physiological and molecular changes linked to depressive-like behaviors as a result of chronic stress. Cumulative evidence shows that counteraction or prevention of these alterations in neurons, occasionally in a projection-specific manner, can enhance stress adaptation or resilience.

Chronic stress induces various changes in the brain, including in the bed nucleus of the stria terminalis (BNST) and the ventral tegmental area (VTA). The neural projections from the BNST …

Regulating The Care Boom: Labor Standards Enforcement And Paid In-Home Care Work, Isaac Jabola-Carolus

Dissertations, Theses, and Capstone Projects

In the United States, population aging has driven explosive growth in care-sector occupations, especially among low-wage home care aides who provide long-term assistance to older adults. These aides, predominantly women and disproportionately people of color, now represent one of the country’s largest and fastest-growing occupational groups. In recent decades, economic inequality and meager social policies have also spurred demand for nannies, housecleaners, and other domestic workers—occupations heavily reliant on immigrant women, many undocumented. While scholarly and public discourse has addressed labor shortages and job quality in such occupations, a related problem is the widespread violation of labor standards, including minimum …

Audible Futures: Scenes Of Sonic Encounter In Cold War Kurdistan, 1923–2023, Nicholas S. Glastonbury

Dissertations, Theses, and Capstone Projects

This dissertation examines a century of cultural politics in Kurdistan, from 1923 to 2023, and it does so from a relatively marginal vantage point in most histories of Kurdistan: that of the Soviet Caucasus. It takes as its primary object the cultural and political itineraries of sonic media and listening in Kurdistan, from Soviet Kurdish radio broadcasting and pirated cassettes to postsocialist archives, DJ booths, and streaming music. These itineraries map not only the emergence and circulation of Kurdish notions of tradition, heritage, and cultural memory, but also the methods of counterinsurgency deployed by the states that occupy Kurdistan. In …

Examining The Prevalence And Psychopathological Correlates Of Paraphilic Interests In A Non-Clinical Sample, Dylan H. Abrams

Dissertations, Theses, and Capstone Projects

The paraphilias are among the most contentious diagnoses in contemporary psychological discourse. One of the major debates is over the extent to which paraphilic interests and behaviors should be considered “deviant.” To address this issue, extant research has examined the prevalence of paraphilic interests and their correlation with psychopathology. Though findings suggest that certain paraphilic interests are relatively common, existing data may misrepresent true prevalence rates due to racially and ethnically homogenous sampling. Additionally, though an association between paraphilias and psychopathology has been found in forensic and clinical samples, this relation may not generalize to all individuals with paraphilic interests. …

Impact Of Sex In Luxury Fashion Advertisements On Brand Attractiveness And Identification, Alyssa Dana Dana Adomaitis, Diana Saiki, Juan Del Pozo Severino

Publications and Research

Purpose

This study examined perceived brand attractiveness of and identification with fashion luxury brands given different levels of sexuality in advertisements. Sex in advertisements has become increasingly more common to generate attention and interest in fashion luxury products, with limited research on its influence on the consumer. However, the use of sexuality in luxury advertisements may counter the ethical expectations of brands by the current consumer in the United States.

Design/methodology/approach

A sample of 1,266 males and females completed a survey on brand attractiveness and identification after examining an advertisement of a luxury fashion product. Participants were assigned an advertisement …

Colonial Investments: The Global Coordinates Of The English Political Imaginary, 1628–1668, Nathan D. Nikolic

Dissertations, Theses, and Capstone Projects

The main question my dissertation attempts to address is: what role did the expansion of English colonial trades play in the transformation of English society and government between the Petition of Right and the early years of the Restoration (1628-1668)? My thesis is that during this period, colonial expansion rose to the level of a general national interest and that many early seventeenth-century texts index the complexities and tensions of this development. As a small but very organized group of merchants, peers, and MPs mobilized the military and financial technologies of colonization to support Parliament’s war against Charles I, their …

You Don’T Even Need The Ghosts: A Writer’S Look At The Turn Of The Screw, Andrea M. Schenkel

Dissertations, Theses, and Capstone Projects

The novella Turn of the Screw by Henry James was first published in 1898 as a serialized novel in Collier's Magazine. The short novel is characterized by its concise language. James chooses words carefully and consciously. The linguistic compression forces the reader to deal intensively with the main protagonists of the novel: the Governess, the children, Miles and Flora, and Mrs. Grose. Nothing is as it seems. James aims to challenge the reader by forcing them to constantly question what they read.

Countless essays have been written about the text since the novel was published. The figures, especially those …

Narratives In, On, And Around Contemporary Queer Film: A Study Of Adam And Its Paratexts, Jeremy Stoller

Dissertations, Theses, and Capstone Projects

Film’s ability to present and inspire desire, and to realize alternate worlds, render it a uniquely potent medium for expressing queerness. Because of this potency, and because films are among the most prominent ways that LGBTQ+ people are represented in society, queer film can feel both deeply personal and highly political for LGBTQ+ identifying audiences. But movies do not merely offer statements about political systems, they are also made within and reflective of those systems.

Scholars have thoroughly investigated films and our relationships to them for productive ways of seeing gender, sexuality, desire, and oppression. But the conversations about how …

“Bending The Law” – Weimar Judiciary And The Political Bias Paradox Of The Legal System, Irit Bloch

Dissertations, Theses, and Capstone Projects

This interdisciplinary, microhistory project which draws on historical, legal and sociological methodologies, examines the relationship between a new and unstable democracy and a hostile judicial system in the Weimar Republic (Germany, 1919-1933). In particular, it asks how Weimar judges who were bound to codes of law and adhered to the rule of law were able to manipulate laws and to produce judgments along ideological lines while keeping a semblance of legality. By analyzing judicial decisions in three non-political, criminal cases, this research explains the mechanism of subversion and offers a nuanced explanation for the judiciary's motivations to abuse the law. …

Reflections On The Digital Memory Of Trans-Atlantic Slavery, Vinh T. Pham

Dissertations, Theses, and Capstone Projects

Within the scope of digital humanities scholarship, this thesis interrogates ‘memory’ as a conceptual frame for remembering Black life, both past and present, in the face of missing historical data and in the afterlife of trans-Atlantic slavery. Such a concept—increasingly taken up as method in the humanities, along with related allusions to the ephemeral, spectral, or haunted—is sought to refuse historiographical and techno-scientific claims to empirical certainty or transparency, and instead affirm its gaps and absences as themselves productive sites for self-reflexive speculation on the complexities of lived experience. Applied to the digital study of trans-Atlantic chattel slavery, memory comes …

This Little Light Of Mine: The History Of The Amalgamated Nursery School, Kimberly F. Vanderbilt

Dissertations, Theses, and Capstone Projects

This research focuses on the history of one small nursery school to analyze the factors that influenced the school: the labor unionists founders, the changing neighborhoods of the Bronx, the Progressive Education Movement and the Women's Leadership Movements that helped define and support the school. Recent policy changes have had impact on this school and on all early childhood programs in New York City.

Fifteenth-Century Sienese Art In Its International Setting: A Case Study Of Cross-Cultural Exchange In Italy And Beyond, Maria Lucca

Dissertations, Theses, and Capstone Projects

Scholars often frame the Republic of Siena as isolationist and inward-looking, yet from its beginning in 1262 the city-state was internationally vital, sending artists to work in foreign cities and calling upon foreign artists to do significant work in Siena. Although Siena temporarily retreated from this internationalism to a period of relative cultural autonomy in the mid-Trecento, in the early Quattrocento it re-opened the gates of its medieval walled city to artistic interchange between Sienese and Florentine sculptors, setting in motion the dramatic shift that occurred in the mid-Quattrocento. Sienese sculptors embraced the Renaissance artistic humanism flourishing in Florence and …

Breaking Down Bias: A Comparative Analysis Of General Public And Police Officer Attitudes Toward Mental Illness And Officer Decision-Making In Mental Health Crises, Therese L. Todd

Dissertations, Theses, and Capstone Projects

Police responses to persons with mental illness (PMIs) compared to those without appear to be more likely to result in negative outcomes, underscoring the importance of understanding these interactions and the factors that may influence them. Relatively little research has examined officer attitudes toward mental illness, and no study has examined implicit bias toward mental illness among police officers or how police culture may impact outcomes in mental health crises. The present study sought to: 1) measure explicit and implicit bias toward PMIs among the general public and police officers to understand how these constructs may vary among these populations; …

Evaluating The Effect Of Cctv On Crime Occurrence And Case Clearances In Fayetteville, North Carolina: A Microsynthetic Control Quasi-Experiment, Amanda L. Thomas

Dissertations, Theses, and Capstone Projects

Closed circuit television (CCTV) surveillance cameras have become widely accepted as a traditional crime prevention measure used by law enforcement agencies across the globe. The proliferation of CCTV technology as a crime reduction mechanism has led to a corresponding growth in the evidence base of its effect on crime. While CCTV is generally associated with a moderate reduction in crime, these evaluations have suffered from certain limitations. First, rigorous quasi-experimental designs using advanced matching techniques have not been used enough in CCTV research and second, these evaluations remain largely one-dimensional, as additional outcome measures and other camera-specific features have gone …

A Difference Of One's Own: Race, Sex, Modernism, Ryan L. Tracy

Dissertations, Theses, and Capstone Projects

“A Difference of One’s Own” demonstrates that deconstructive conceptions of race lie at the heart of the modernist canon’s experimental representations of selfhood. Drawing on recent and canonical scholarship in Modernist Studies, Black Studies, Deconstruction, Queer Theory, Critical Theory, and Feminist Studies, I look at moments in modernist-era literature where the need to represent racial blackness, whether as a descriptor that defines one’s self-identity or the identity of another person, fails to draw a coherent line of difference between people, communities, selves, and importantly, the literatures that are thought to adhere to hard and fast racial distinctions. “Part I: …

Take Back The Power: The Fall And Rise And Fall Of New York City's Transport Workers Union Local 100, 1975–2009, Marc Kagan

Dissertations, Theses, and Capstone Projects

Take Back the Power: The Fall and Rise and Fall of Transport Workers Union Local 100, 1975-2009 tracks the history of this strategically significant union from the onset of New York City’s fiscal crisis in 1975 to the end, in 2009, of a second attempt to free transit workers from the grip of neoliberal economic austerity.

The first effort began in 1978 and culminated with the eleven-day 1980 transit strike, initiated by union dissidents over the opposition of the union president, but abruptly ended by him before a decisive victory could be won. That president, and his successors, reconciled themselves …

Grand Strategy At The End Of History: Chinese Strategic Thought In The 21st Century And Its Western Perceptions, Daniel A. Rogers

Dissertations, Theses, and Capstone Projects

Too often does the study of grand strategy, especially as it is conducted by academics based in the United States, take on an ethnocentric perspective which would lead American audiences to believe it is their country alone which possesses a coherent grand strategy that seeks to secure the national interest and nothing more. This chauvinistic approach not only leaves the majority of the world out of the conversation of grand strategy, but also results in the characterizing of the strategic approaches of non-Western states as disruptors of the foreign policy goals of the United States. The People’s Republic of China …

Health Care Providers' Attributions Of Blame For Unintended Pregnancy And Hiv Acquisition Among Cisgender Women, Alison J. Goldberg

Dissertations, Theses, and Capstone Projects

Unintended pregnancy and HIV are both possible but preventable outcomes of vaginal sex, and both can be prevented in similar ways (condoms, daily oral medication, etc.). Despite these similarities, providers more readily prescribe contraception to cisgender women, compared to PrEP (Guttmacher Institute, 2021; Raifman et al., 2019). Providers’ differential willingness to prescribe each medication cannot be attributed merely to differences in women’s need for pregnancy prevention vs. HIV prevention, as women account for nearly 20% of new HIV infections (CDC, 2021). Through three studies, I examined whether perceivers’ support for harm reduction (i.e., prescribing PrEP/contraception) and behavior reduction (i.e., discouraging …

Bargaining In The Shadow Of The Truth: How Client Assertion, Perception Of Guilt, And Predictive Inaccuracy Influence Plea Recommendations, Anna D. Vaynman

Dissertations, Theses, and Capstone Projects

Over the past few decades, the largely hidden, secretive, and widely used system of plea bargaining has caught the fervent attention of scholars. The Shadow of the Trial model has been central to much of the plea-bargaining literature, despite significant critiques about its oversimplification. The model posits that defendants and their attorneys make plea decisions based largely on the estimated probability of conviction and the severity of the sentence to which the defendant could be exposed at trial.

The model, however, assumes that all actors are rational, equally risk averse, have no competing interests, and possess high predictive accuracy. It …

Overview Of The Intern Position At Sexgenlab And The Importance Of Public Scholarship, Elizabeth S. Chapin

Dissertations, Theses, and Capstone Projects

This paper represents a culmination of my time interning with SexGenLab and addresses the work I did from September 2022 to July 2023. This paper discusses the work that was completed, and why it is important, indicating how it contributes to the world at large outside of academia. I discuss my motivations and intentions relating to the internship, and how I was able to carry out my goals through the work I completed. In addition, this paper discusses the nature and importance of public scholarship, and how this internship contributed to that mission.

Kinetics Of Photochemical And Mechanochemical Organic Reactions On Surface, Yerzhan Zholdassov

Dissertations, Theses, and Capstone Projects

Solvents used in traditional chemical processes account for a large percentage of reaction mass and waste and can pose significant environmental and health risks. The environmentally friendly nature of mechanochemistry, in addition to other benefits, makes it a promising approach for sustainable chemistry over traditional solvent-based methods. However, it is still not a widely adopted method for performing chemical reactions on an industrial scale. This is partially due to the significant challenge associated with understanding the reaction kinetics under mechanochemical conditions. Many variations of scanning probe lithography (SPL) techniques are able to manipulate the organic molecules with precise control over …

Body Check: Transgressive Body Politics Of Gina Pane, Orlan, And Deborah De Robertis, Avant-Garde Performance Artists In France, 1960s–Present, Patricia Anne Winter

Dissertations, Theses, and Capstone Projects

In the 1960s, when Gina Pane and Orlan were trying to gain a foothold in the art world, it was very much a man’s world. This created obstacles for them, yet, at the same time, being relegated to the margins, they were free to experiment and were less visible as objects of the gaze.

The point of departure of my study is the realization that a woman’s body is what most defines her identity (Alcoff, Bordo, Butler, Gonzenbach, Mulvey, Spelman, Suleiman). The female body is the material site from which I discuss how, and to what ends, women avant-garde performance …

Situating The Child’S Voice Within Children’S Fashion: An Interdisciplinary Examination Of The Child’S Engagement With The Clothing They Wear, Melinda Byam

Dissertations, Theses, and Capstone Projects

This paper examines the child’s relationship with children’s fashion, the clothing they wear, and their fashion consumption practices. Using a wardrobe approach to fashion, and an understanding of the child as the expert in their own lives, the author questions how the child engages, interacts, and experiences children’s fashion considering that how they use, think, and speak about their clothing is minimally consulted. Situating this research within a theoretical foundation set by Goffman and Simmel (social behavior), Featherstone (consumer culture), and Merleau-Ponty and Entwistle (embodiment), this text examines fashion from the point of view of the child, hypothesizing how future …

How Smoking Became A Moral Issue: A Complex Systems Perspective On Moralization, Matthew Vanaman

Dissertations, Theses, and Capstone Projects

When something is morally wrong, it is in the moral domain; when something becomes morally wrong, it is moralized. But how do we know when something is in the moral domain, and how can we tell whether something is becoming moralized? The empirical study of morality, or a given person’s judgment of what constitutes moral virtue or vice, has historically approached these questions through one of three theoretical perspectives: cognitivism, which argues that people primarily or mostly use effortful thought to judge right from wrong; emotivism, which sees these judgments as flowing from emotion; and dual-process models, which …

White Supremacist Print Culture And The Creation Of White Working-Class Ideology In 1860s New York City, Anna Meyer

Dissertations, Theses, and Capstone Projects

J. H. Van Evrie believed in the biological basis of white racial supremacy and Black inferiority beliefs which he spread in his publications throughout the 19^th century. He generated support for Copperhead politicians, pro-slavery Northern Democrats, who would enact his racial policies, in his newspaper the Weekly Caucasian, published in New York City during the Civil War. He adapted the presentation of his racial theories to appeal to the economic concerns of among working-class white men and Irish immigrants by using allegories about the Civil War. The newspaper created a sense of white nationalism and racial solidarity with …

André Mocquereau's Theory Of Rhythm, Charles Weaver

Dissertations, Theses, and Capstone Projects

This dissertation examines the theory of rhythm developed by Dom André Mocquereau (1849–1930), a French Benedictine monk. Mocquereau’s theory was originally conceived as a method for performing Gregorian chant and has been the source for numerous publications and recordings since the beginning of the twentieth century. This dissertation places Mocquereau’s theory in the context of both the evolving performance practice of medieval monophony and the history of music theory in the nineteenth and twentieth centuries. Chapter 1 surveys the history of the notation of Gregorian chant, introducing the problem of constructing a rhythmic practice from historical sources. Chapter 2 examines …