Digital Commons Network^™

Reflections On The Digital Memory Of Trans-Atlantic Slavery, Vinh T. Pham

Dissertations, Theses, and Capstone Projects

Within the scope of digital humanities scholarship, this thesis interrogates ‘memory’ as a conceptual frame for remembering Black life, both past and present, in the face of missing historical data and in the afterlife of trans-Atlantic slavery. Such a concept—increasingly taken up as method in the humanities, along with related allusions to the ephemeral, spectral, or haunted—is sought to refuse historiographical and techno-scientific claims to empirical certainty or transparency, and instead affirm its gaps and absences as themselves productive sites for self-reflexive speculation on the complexities of lived experience. Applied to the digital study of trans-Atlantic chattel slavery, memory comes …

Synthesis Of Biologically Active Tropolones And Stereochemically Rich Compounds Via Cross-Coupling Reactions, Nana B. Agyemang

Dissertations, Theses, and Capstone Projects

Over the past years the Murelli lab has established research based on the synthesis and biological evaluations of alpha-hydroxytropolones (alpha-HTs). These seven-membered aromatic rings have three contiguous oxygen atoms that chelates to metals, thus, biologically having the ability to bind dinuclear metalloenzymes and promoting inhibition. Synthetic routes to alpha-HT’s are scarce and therefore has been the main driving force in developing efficient and general synthetic methods to obtain variations in alpha-HTs, enabling SAR studies. The Murelli lab have therefore developed an oxidopyrylium cycloaddition/ring-opening strategy that is able to generate polysubstituted alpha-HTs starting from kojic acid, a cheap and readily available …

Stereospecific Cross-Coupling Reactions With Enantioenriched Electrophiles, Iv Kraja

Dissertations, Theses, and Capstone Projects

We have developed a novel palladium-catalyzed stereospecific C(sp³)–C(sp³) Stille cross-coupling reaction between carbastannatrane nucleophiles and α-(trifluoromethyl) benzylic tosylates. This constitutes the first example of a stereospecific C(sp³)–C(sp³) cross-coupling reaction using an enantioenriched electrophile and an alkyltin nucleophile. This system has the potential to be extended to cross-coupling reactions using configurationally stable enantioenriched nucleophiles, thus enabling stereochemical control of two newly formed contiguous stereocenters. Generating enantioenriched α-(trifluoromethyl) benzylic compounds also has importance in pharmaceutical and agrochemical industries.

Through the development of this reaction, our findings show that the addition …

On The Spectrum Of Quaquaversal Operators, Josiah Sugarman

Dissertations, Theses, and Capstone Projects

In 1998 Charles Radin and John Conway introduced the Quaquaversal Tiling. A three dimensional hierarchical tiling with the property that the orientations of its tiles approach a uniform distribution faster than what is possible for hierarchical tilings in two dimensions. The distribution of orientations is controlled by the spectrum of a certain Hecke operator, which we refer to as the Quaquaversal Operator. For example, by showing that the largest eigenvalue has multiplicity equal to one, Charles Radin and John Conway showed that the orientations of this tiling approach a uniform distribution. In 2008, Bourgain and Gamburd showed that this operator …

On The Second Case Of Fermat's Last Theorem Over Cyclotomic Fields, Owen Sweeney

Dissertations, Theses, and Capstone Projects

We obtain a new simpler sufficient condition for Kolyvagin's criteria, regarding the second case of Fermat's last theorem with prime exponent p over the p-th cyclotomic field, to hold. It covers cases when the existing simpler sufficient conditions do not hold and is important for the theoretical study of the criteria.

Attenuated Typicality Effect In Category-Based Inferences: Implications For Autism Spectrum Disorder, Janani Rajagopalan

Dissertations, Theses, and Capstone Projects

Individuals diagnosed with Autism Spectrum Disorder (ASD) often encounter challenges in assimilating atypical exemplars into their categorical prototypes, a cognitive hurdle that can impact their interpretative and integrative capacities. Addressing this problem, the present research sought to develop a robust methodological approach to reduce the effect of this disparity. We examined the elements embedded within the category's internal structure, with the intention of experimentally attenuating the pronounced typicality effect, which is often exaggerated in ASD.

Across four experiments, the thesis investigated the cognitive and neural underpinnings that shape the access to the typicality gradient intrinsic to a category's structure. The …

Dynamics Of Spin And Charge Of Color Centers In Diamond Under Cryogenic Conditions, Richard G. Monge

Dissertations, Theses, and Capstone Projects

Individual quantum systems in semiconductors are currently the most sought-after platform for applications in quantum science. Most notably, the nitrogen-vacancy (NV) center in diamond features a defect deep within the electronic bandgap, making it amenable for precise manipulation to help pave the way to perform fundamental quantum physics experimentation. The NV center also offers long coherence times and versatile spin-dependent fluorescent properties, making it an ideal candidate for a nanoscale magnetometer. Furthermore, multi-color excitation offers deterministic charge state manipulation. While ambient operation has been key to their appeal, bringing NVs to cryogenic conditions opens new opportunities for alternate forms of …

Automatic Analysis Of The Frequency, Vigor, And Complexity Of Spontaneous Locomotion Bouts Of Mice With Loss And Gain Of Function Of The G Protein-Coupled Receptor Smoothened In Cholinergic Neurons, Aleksandra Feshchenko

Dissertations, Theses, and Capstone Projects

Locomotion, a fundamental behavior, is classically assessed using simple metrics of velocity and total distance moved in an open field. This behavior however offers rich data about the organization and breadth of actions an animal can take while only facing limitations due to the bio-mechanical constraints of the organism. Importantly, these actions are not biased towards a particular task-solution space imposed by many behavioral paradigms. Here, to analyze motor complexity in freely ambulating mice, we developed a method for the automatic and unbiased identification of locomotor bouts which we call Bout Finder (BF). This analysis utilizes Open Feld data to …

Weathering The Perfect Legal Storm: Novel Virus, Novel Instruction, Novel Course, Marissa Moran

Publications and Research

For this legal educator, in the spring and fall of 2020, three simultaneous and novel events-Corona virus, virtual synchronous instruction, and teaching a new interdisciplinary course for the first time, created an environment that could have resulted in the perfect legal storm. Instead, these events contributed to beneficial teaching and learning experiences from which arose many “first-ever” innovative faculty and student endeavors.

Kinetics Of Photochemical And Mechanochemical Organic Reactions On Surface, Yerzhan Zholdassov

Dissertations, Theses, and Capstone Projects

Solvents used in traditional chemical processes account for a large percentage of reaction mass and waste and can pose significant environmental and health risks. The environmentally friendly nature of mechanochemistry, in addition to other benefits, makes it a promising approach for sustainable chemistry over traditional solvent-based methods. However, it is still not a widely adopted method for performing chemical reactions on an industrial scale. This is partially due to the significant challenge associated with understanding the reaction kinetics under mechanochemical conditions. Many variations of scanning probe lithography (SPL) techniques are able to manipulate the organic molecules with precise control over …

Applying Structural Equation Modeling To Better Understand The Relationship Between Stressors, Social Support And Wellbeing In The Lives Of Spouse Dementia Caregivers, Craig Holden

Dissertations, Theses, and Capstone Projects

Applying Structural Equation Modeling to Better Understand the Relationship Between Stressors, Social Support and Wellbeing in the Lives of Spouse Dementia Caregivers considers the utility of Pearlin et al.’s (1990) stress process model in understanding the needs of spouse caregivers. Data were drawn from eight biennial waves of the University of Michigan Health and Retirement Study (HRS) and analyzed using structural equation modeling. The final study sample comprised 774 spouses, average age 73, who were categorized based on Alzheimer’s Disease and Related Dementia (ADRD) and non-ADRD caregiver status. Results showed that for the study sample as a whole, social support …

Uncertainties In Retrieval Of Remote Sensing Reflectance From Ocean Color Satellite Observations, Eder I. Herrera Estrella

Dissertations, Theses, and Capstone Projects

Ocean Color radiometry uses remote sensing to interpret ocean dynamics by retrieving remote sensing reflectance (������) from satellite imagery at different scales and over different time periods. ������ spectrum characterizes the ocean color that we observe, and from which we can discern concentrations of chlorophyll, organic and inorganic particles, and carbon fluxes in the ocean and atmosphere. ������ is derived from the total radiance at the top of the atmosphere (TOA). However, it only represents up to ten percent of the total signal. Hence, the retrieval of ������ from the total radiance at TOA involves the application of atmospheric correction …

Electrochemical Resistive-Pulse Sensing In Biological Systems, Rui Jia

Dissertations, Theses, and Capstone Projects

Electrochemical resistive-pulse (ERP) sensing with conductive carbon nanopipettes (CNPs) is a powerful technique for detecting single nanoscopic entities, such as single liposomes and biological vesicles, enabling qualitative and quantitative analysis of the redox molecules contained in such entities. ERP experiments were first carried out in biological system by inserting a conductive carbon nanopipette into a macrophage cell to sample single vesicles and measuring reactive oxygen and nitrogen species (ROS/RNS) contained inside them.

Besides sensing intracellular vesicles in macrophage cells, we applied this technique to direct detect single extracellular vesicles (EVs) released from a specific cell, and analysis of reactive oxygen …

Out-Of-Distribution Generalization Of Deep Learning To Illuminate Dark Protein Functional Space, Tian Cai

Dissertations, Theses, and Capstone Projects

Dark protein illumination is a fundamental challenge in drug discovery where majority human proteins are understudied, i.e. with only known protein sequence but no known small molecule binder. It's a major road block to enable drug discovery paradigm shift from single-targeted which looks to identify a single target and design drug to regulate the single target to multi-targeted in a Systems Pharmacology perspective. Diseases such as Alzheimer's and Opioid-Use-Disorder plaguing millions of patients call for effective multi-targeted approach involving dark proteins. Using limited protein data to predict dark protein property requires deep learning systems with OOD generalization capacity. Out-of-Distribution (OOD) …

The Role Of Nuclear Quantum Effects In Supercooled Water And Amorphous Ice, Ali H. Eltareb

Dissertations, Theses, and Capstone Projects

Water is one of the most important substances on Earth and plays a fundamental role in numerous scientific and engineering applications. Interestingly, water behaves much differently than other liquids. For example, water shows an anomalous density maximum at 277 K, the solid phase (ice) is less denser than the liquid, and its thermodynamic response functions, such as the specific heat C_P and isothermal compressibility κ_T, also increase anomalously upon cooling. In the glassy state, water can exist in two different forms, low-density and high-density amorphous ice (LDA and HDA). While water has been scrutinized for many centuries, …

Extraction, Property, And Rights In Southeastern Arabian Seascapes C.1820–Present, Scott Erich

Dissertations, Theses, and Capstone Projects

This dissertation is a historical and ethnographic examination of fish, pearl, sponge, and oil extraction in the Persian Gulf and Gulf of Oman. These waters, which were fished and labored upon in much of the same way for millennia, have, in the last two centuries, undergone a sea change. Regimes of property and rights have transformed the ocean from a wild and undifferentiated space into a place which is enclosed, privatized, industrially fished, drilled, and otherwise despoiled. This dissertation, building on recent works in environmental history, Indian Ocean studies, and legal and economic anthropology, probes the many cultural, religious, social, …

Quantifying Temperature-, Pressure-, And Nuclear Quantum Effects On Hydrophobic And Hydrophilic Water-Mediated Interactions, Justin T. Engstler

Dissertations, Theses, and Capstone Projects

Water-mediated interactions (WMIs) are responsible for diverse processes in aqueous solutions, including protein folding and nanoparticle aggregation. WMI may be affected by changes in temperature and pressure, and hence, they can alter chemical/physical processes that occur in aqueous environments. Traditionally, attention has been focused on hydrophobic interactions while, in comparison, the role of hydrophilic and hybrid (hydrophobic–hydrophilic) interactions have been mostly overlooked. Here, we study the role of T and P on the WMI between nanoscale (i) hydrophobic–hydrophobic, (ii) hydrophilic–hydrophilic, and (iii) hydrophilic–hydrophobic pairs of (hydroxylated/non-hydroxylated) graphene-based surfaces. We find that hydrophobic, hydrophilic, and hybrid interactions are all sensitive to …

Construction And Performance Optimization Of Bioconjugated Nanosensors For Early Detection Of Breast Cancer And Pro-Inflammatory Diseases, Pooja Gaikwad

Dissertations, Theses, and Capstone Projects

In recent years, nanosensors have emerged as a tool with strong potential in medical diagnostics. Single-walled carbon nanotube (SWCNT) based optical nanosensors have notably garnered interest due to the unique characteristics of their near-infrared fluorescence emission, including tissue transparency, photostability, and various chiralities with discrete absorption and fluorescence emission bands. Additionally, the optoelectronic properties of SWCNT are sensitive to the surrounding environment, which makes them suitable for in vitro and in vivo biosensing. Single-stranded (ss) DNA-wrapped SWCNTs have been reported as optical nanosensors for cancers and metabolic diseases. Breast cancer and cardiovascular diseases are the most common causes of death …

Evaluation Of Symmetric Functions And Boolean Functions Over Stochastic Input, Naifeng Liu

Dissertations, Theses, and Capstone Projects

In our daily life, we often face situations where we need to make precise judgments based on initially unknown information, while gathering all the evidence to make informed conclusions can be very costly. In this dissertation, we explore the problem of optimizing the decision-making process under uncertainty, and we focus on problems that can be found in both theoretical computer science and discrete mathematics. The primary goal is to develop approximation algorithms with guaranteed worst-case performance. These algorithms aim to minimize the expected cost of acquiring information necessary for evaluating fundamental functions, such as Boolean and symmetric functions. Furthermore, we …

The Development Of Novel Radioscandium And Hydroxypyridinonate Based Radiopharmaceuticals, Michael Phipps

Dissertations, Theses, and Capstone Projects

The use of radiometals in radiopharmaceutical development has drastically increased over the last decade, owed in part to the diverse chemistry and emission characteristics of the radiometals, which allow chemists to create a toolbox of agents to better tailor patient care. Challenges with the use of radiometals include the selection of the metal and the development of optimized chelators to cover the diverse chemistry of the metals which make up the majority of the periodic table. Scandium is the first transition metal and has multiple radioisotopes whose emission characteristics have potential application in medicine. 3,4,3-LI(1,2-HOPO) is a chelator whose denticity, …

Fuglede's Conjecture In Some Finite Abelian Groups, Thomas Fallon

Dissertations, Theses, and Capstone Projects

This dissertation thoroughly examines Fuglede's Conjecture within some discrete settings, shedding light on its intricate details. Fuglede's Conjecture establishes a profound connection between the geometric property of being a tiling set and the analytical attribute of being a spectral set. By exploring the conjecture on various discrete settings, this thesis delves into the implications and ramifications of the conjecture, unraveling its implications within the field.

Nonlinear Processes In Room Temperature Exciton-Polaritons, Prathmesh Deshmukh

Dissertations, Theses, and Capstone Projects

Strong light-matter coupling in solid state systems is an intriguing process that allows one to exploit the advantages of both light and matter. In this context, microcavities have become essential platforms for studying the strong coupling regime, where hybrid light-matter states known as exciton-polaritons form, leading to enhanced light matter interaction, modified material properties, and novel quantum phenomena. In this thesis, we explore the phenomenology of exciton-polaritons in strained TMD microcavities, 2D perovskites, fluorescent proteins and organic dyes encompassing thermalization, polariton lasing, and the observation of nonlinear effects.

Transition metal dichalcogenides (TMDs) have emerged as a remarkable class of two- …

Form In Hip-Hop Music: Sections, Songs, And History, Stephen M. Gomez

Dissertations, Theses, and Capstone Projects

This dissertation explores musical form in recorded hip-hop music from 1979–present. Form, defined as the large-scale organization of songs, is a parameter that artists consider in the creative process and fans experience while listening. Hip-hop’s historical foundation as a live, improvised, party-oriented genre influenced formal functions and patterning from the earliest days of its popular recorded life, beginning with the Sugar Hill Gang’s “Rapper’s Delight” in 1979. While many of the section and song form labels used by scholars of pop-rock music are transferable to the analysis of hip-hop, the latter genre conveys a unique sense of time rooted in …

Optimization And Application Of Graph Neural Networks, Shuo Zhang

Dissertations, Theses, and Capstone Projects

Graph Neural Networks (GNNs) are widely recognized for their potential in learning from graph-structured data and solving complex problems. However, optimal performance and applicability of GNNs have been an open-ended challenge. This dissertation presents a series of substantial advances addressing this problem. First, we investigate attention-based GNNs, revealing a critical shortcoming: their ignorance of cardinality information that impacts their discriminative power. To rectify this, we propose Cardinality Preserved Attention (CPA) models that can be applied to any attention-based GNNs, which exhibit a marked improvement in performance. Next, we introduce the Directional Node Pair (DNP) descriptor and the Robust Molecular Graph …

Theorizing Racial Democracy, Teófilo De Souza Carmo Reis

Dissertations, Theses, and Capstone Projects

The critical philosophy of race has shown recent growth, but it tends to focus too much on the United States. This leaves many race-related concepts and phenomena from other parts of the world underexplored. I help to fill this gap by exploring the idea of "racial democracy" in Brazil, which is a form of racial ignorance that is prevalent in that country. Specifically, I am interested in the epistemic aspects of this mechanism of creating and propagating racial ignorance.

To achieve this goal, I begin by introducing Charles Mills' concept of white ignorance and other influential works in social epistemology. …

Centrality Effects On Heavy-Flavor Quark Production And Invariant Yield In Phenix Proton–Gold Collisions At Center-Of-Mass Energy 200 Gev, And Assembly, Testing, Calibration, And Installation Of The Sphenix Hadronic Calorimeters, Daniel Richford

Dissertations, Theses, and Capstone Projects

Hadrons created in heavy-ion collisions interact with the open color-charge of the quark-gluon plasma through their constituent quarks. The medium imparts substantial modifications to heavy-flavor hadrons' momentum spectra. For collisions of small systems, the centrality of those collisions affects both the production of heavy-quarks and the medium modifications that the heavy-quarks experience. This analysis uses the PHENIX detector at the Relativistic Heavy Ion Collider, which collected data from proton--gold collisions in 2015, with a trigger to preference the collection of the five-percent most-central collisions. This analysis uses the distance-of-closest-approach of electron tracks to study semileptonic decays from charm and bottom …

Rotation Period Distributions And Light Curve Morphologies Of Low Mass Stars And Young Associations, Mark Popinchalk

Dissertations, Theses, and Capstone Projects

This dissertation is centered around the rotation periods of low-mass stars and association of young stars. Rotation periods are a link to the age of the star, as they lose angular momentum over time. To understand how this angular momentum evolves requires understanding the rotation period distributions of a range of stellar types and ages. Traditionally, M dwarf stars and young stars were challenging to describe due to their intrinsic faintness and dispersed sky positions respectively. I approached this subject from several directions.

Separation Of Zr From Complex Matrices For Isotope Harvesting Applications, Jake A. Bence

Dissertations, Theses, and Capstone Projects

Zr isotopes have various applications in nuclear science, such as ⁸⁶Zr and ⁸⁹Zr in nuclear medicine, ⁸⁸Zr as a diagnostic isotope relevant to stockpile stewardship, and the fission product ⁹⁵Zr useful as an s-process branch nucleus for study in astrophysics. To access these isotopes of interest, dedicated production methods and subsequent processing chemistry are required. Direct production routes can be technically challenging and difficult to obtain enough activity to meet demand. The processing chemistry of Zr isotopes is tedious due to the tendency for Zr to hydrolyze in solution without highly acidic conditions or a strong …

Tunable Linear And Nonlinear Metasurfaces Based On Hybrid Gold-Graphene Plasmons, Matthew Feinstein

Dissertations, Theses, and Capstone Projects

Optical Metasurfaces are planar structures that are patterned with subwavelength structures and are very thin compared to the wavelength of light. Despite their thinness, these structured materials can strongly interact with incident light to effect the functionalities of conventional optical components, such as rotation of the polarization state, beam steering, lensing, spectral filtering, and holography, to name a few. Metasurfaces can also facilitate nonlinear optical effects, such as the mixing of beams at different frequencies to generate a beam at a new frequency.

The ability to alter the behavior of a metasurface during operation is highly desired for applications such …

Towards Interpretable Machine Reading Comprehension With Mixed Effects Regression And Exploratory Prompt Analysis, Luca Del Signore

Dissertations, Theses, and Capstone Projects

We investigate the properties of natural language prompts that determine their difficulty in machine reading comprehension tasks. While much work has been done benchmarking language model performance at the task level, there is considerably less literature focused on how individual task items can contribute to interpretable evaluations of natural language understanding. Such work is essential to deepening our understanding of language models and ensuring their responsible use as a key tool in human machine communication. We perform an in depth mixed effects analysis on the behavior of three major generative language models, comparing their performance on a large reading comprehension …