Digital Commons Network^™

The Pandemic Anxiety Inventory: A Validation Study, Irvin Sam Schonfeld, Tasmyn Prytherch, Mark Cropley, Renzo Bianchi

Publications and Research

The Pandemic Anxiety Inventory (PAI) assesses anxiety symptoms individuals attribute to the presence of a pandemic. We conducted this study of 379 British adults during the COVID-19 pandemic and found that the PAI exhibited excellent reliability and solid criterion validity. Pandemic anxiety was associated with reduced social support, anticipated life changes, financial strain, job loss, economic insecurity, and the hospitalization or death of a close friend or relative. Using correlational and bifactor analyses, we found that the PAI demonstrated solid convergent and discriminant validity. The findings suggest that the PAI can be used in research and clinical practice.

Eddie Ellis, Credible Messengers And The Neo-Liberal Imagination Of Anti-Violence, David C. Brotherton

Publications and Research

I trace the socio-historical pathway of the concept of the credible messenger and related youth anti-violence interventions from the 1930’s to a more radically imagined iteration by Eddie Ellis in the 1980s. The focus shifts to its present-day iterations as I review two widely adopted anti-violence programs. I conclude that today credible messengers and anti-violence interventions are: (i) primarily imagined within a framework of neo-liberal possibility; (ii) valued for their contributions on individual and/or group behavioral change; and (iii) conceived in programs outside of any discourse on the structural roots of crime, collective agency, or the historical struggle for social …

The Pandemic Anxiety Inventory: A Validation Study, Irvin Sam Schonfeld, Tasmyn Prytherch, Mark Cropley, Renzo Bianchi

Publications and Research

The Pandemic Anxiety Inventory (PAI) assesses anxiety symptoms individuals attribute to the presence of a pandemic. We conducted this study of 379 British adults during the COVID-19 pandemic and found that the PAI exhibited excellent reliability and solid criterion validity. Pandemic anxiety was associated with reduced social support, anticipated life changes, financial strain, job loss, economic insecurity, and the hospitalization or death of a close friend or relative. Using correlational and bifactor analyses, we found that the PAI demonstrated solid convergent and discriminant validity. The findings suggest that the PAI can be used in research and clinical practice.

Synthesis Of Fluoroorganics And Applications Of Novel Fluorinated Building Blocks, Wei Wei

Dissertations, Theses, and Capstone Projects

Diastereoselectivity of fluorination of a carbanion alpha to a sulfone in enantiomerically pure N-Boc protected (R)- and (S)-2,2-dimethyl-4-((arylsulfonyl)methyl)oxazolidines has been studied. Fluorination proceeded with good to excellent diastereoselectivity, which was base-dependent and was highest with lithium diisopropylamide (LDA). Diastereoselectivity also depended on the aryl moiety of the aryl sulfone and was highest with benzothiazole-derived sulfones. Under basic conditions, epimerization at the C–F stereogenic center alpha to the sulfone has been achieved for the first time and proceeded with good to excellent diastereoselectivity, which was highest in the case of a benzothiazole sulfone and with a lithium base. …

Tgf-B Signaling Mechanisms In Caenorhabditis Elegans Response To Bacterial Pathogens, Emma J. Ciccarelli

Dissertations, Theses, and Capstone Projects

When exposed to infection, the nematode C. elegans mounts an innate immune response through secretion of antimicrobial peptides (AMPs). Different signaling pathways in the worm regulate release of these AMPs. One highly conserved pathway is the C. elegans BMP like pathway – regulated by the ligand DBL-1. The DBL-1 pathway is noted for its significant role in development but has also been shown to regulate many post-developmental processes within the worm, including the immune response. We are interested in determining how DBL-1 signaling can mediate a response specific to immunity, separate from its other functions in the worm. Through survival …

How Do Differences In Giving And Receiving Social Support Predict The Frequency Of Substance Use And Polysubstance Use Among Those Who Use Opioids, Afifa Ahmed

Theses and Dissertations

Little is known about the association between giving and receiving social support and substance use frequency. This study investigates how social support can predict substance use and polysubstance use in adults who use opioids and other substances. Survey data demonstrated significant associations between giving emotional support and heroin use frequency.

When We're Coming From What Would An Hiv Doula Do? On Pandemic Time(S), Alexandra Juhasz, Theodore Kerr, Jennifer Brier, Olivia Polk, Alex Fiahlo, Pato Hebert, Salonee Bhaman

Publications and Research

“When We’re Coming From” is a conversation across time and place among a group of writers and artists who are members of the What Would an HIV Doula Do? Collective. Seven of us have come together to have an asynchronous conversation about how our decades-long work to respond to the HIV/AIDS pandemic shapes our experience of the COVID-19 pandemic. Here we share six individual assessments of pandemic time to suggest ways that pandemics(s) shape our sense of time(s). What follows are our meditations on how and when we see ourselves, and the transitions of HIV/AIDS and COVID-19: “AIDS out of …

Compassion-Based Resilience Training (Cbrt) For Frontline Healthcare Workers In Contact With Covid-19 Patients, Michael Perez Sosa

Dissertations and Theses

Objectives: The COVID-19 pandemic has had deleterious consequences for the mental health of frontline healthcare workers worldwide. One systemic review of the literature found high prevalence rates of anxiety (67.55%), depression (58.89%), and stress (62.99%) reported by this population (Vizheh et al., 2020). Additionally, high rates of burnout and symptoms associated with trauma have also been ubiquitous during the pandemic for frontline healthcare workers. The purpose of this study is to investigate Compassion-Based Resilience Training (CBRT) as a remotely delivered intervention for frontline healthcare workers in contact with COVID-19 patients to reduce symptoms associated with stress, depression, anxiety, burnout, and …

The Nexus Of Climate Change And Human Rights: An Examination Of How Social, Political, And Environmental Impacts Of Climate Change Jeopardize The Protection Of Human Rights In The African Sahel, Camden R. Malone

Dissertations and Theses

Climate change is a threat multiplier by its driving forces of environmental stress and scarcity. In the developing world, countries are hit hardest and most frequently by the effects of climate change, such as severe floods, droughts, and desertification. In this thesis, I argue that existing models for the umbrella-term of climate-security underemphasize dimensions of human security through exclusion of HR violations linked to climate such as subjection to food/water stress, compromised health, displacement, and violent conflict. Therefore, the climate-security paradigm should be recast to pay closer attention to its consequences related to human rights protection, which I refer to …

Editorial: Microglia In Neuroinflammation, Pinar Ayata, Ido Amit, Carla M. Cuda

Advanced Science Research Center

Microglia are a resident innate immune cell population of the central nervous system (CNS) derived from yolk sac erythro-myeloid progenitors that migrate to the developing brain prior to the formation of the blood-brain barrier. This critical cell population has gained considerable traction in the literature as it is considered a protective barrier from CNS damage and, yet, can also serve as a primary mediator of neuroinflammation. Under normal physiological conditions, microglia perform homeostatic functions, such as parenchymal surveillance, neurotrophic support, pathogen or debris removal, and maintenance of synaptic homeostasis and neuronal plasticity.

Molecular Mechanism Behind The Safe Immunostimulatory Effect Of Withania Somnifera, Kriti Kalpana, Shen Yap, Moriya Tsuji, Akira Kawamura

Publications and Research

Withania somnifera (L.) Dunal (family Solanaceae) is a medicinal plant known for, among many pharmacological properties, an immune boosting effect. Our recent study revealed that its key immunostimulatory factor is lipopolysaccharide of plant-associated bacteria. This is peculiar, because, although LPS can elicit protective immunity, it is an extremely potent pro-inflammatory toxin (endotoxin). However, W. somnifera is not associated with such toxicity. In fact, despite the presence of LPS, it does not trigger massive inflammatory responses in macrophages. To gain insights into the safe immunostimulatory effect of W. somnifera, we conducted a mechanistic study on its major phytochemical constituent, …

The Impact On Gay Men Of Support And Enforcement Of Workplace Dei Policies: A Meta Analysis, Steven M. Vega

Student Theses and Dissertations

The poor enforcement of workplace DEI policies affects gay men in ways that are unique and invite close attention. The nature of the impact of missing or unsupported DEI policies on gay men has been widely debated in the field of human resources and communication studies, with scholars such as David Wicks, Helen Seitzer, James Ward, and Diana Winstansley arguing that these effects include lasting negative mental and physical health effects and discomfort with self-disclosure in the workplace. However, the existing research on this topic has not sufficiently considered the effects of the poor enforcement of workplace DEI policies side …

Engagement Journalism In Action: Supporting New Yorkers With Long Covid, Sarah Luft

Capstones

What do asthma and long COVID have in common? 1 in 13 U.S. adults are living with them. This report is a recap of my efforts to address the information needs of New Yorkers with long COVID as a student in CUNY's Craig Newmark Graduate School of Journalism engagement program. For my final project, I partnered with THE CITY, a nonprofit news outlet serving New Yorkers, to expand the MISSING THEM project. The report details the what, why, and how of my engagement reporting process, including a community engagement framework, a service journalism series, and lessons to carry forward. You …

Careers Lost To Long Covid, Emily Sauchelli

Capstones

Americans have had to adjust to new lifestyles as a result of the lingering symptoms associated with long COVID. Many have had no choice but to leave the workforce. Those with long COVID are putting the career paths they intended for themselves behind them, due to their inability to keep up with their jobs as a result of their lingering symptoms. Accommodations and resources on how those with long COVID can reenter back into the workforce are coming at a slow pace, as employers are not recognizing how to help those with long COVID stay and thrive in the workplace. …

The Impact Of Covid-19 On Employment Characteristics, Eliana Shatkin

Theses and Dissertations

The following study examines ways in which COVID-19 has disrupted the United States labor market. My findings present disproportionately negative effects of COVID-19 on employment, labor force participation, worker absence, and weekly working hours for the female population in my sample, as well as veterans, disabled persons, and racial minorities.

Genomic Data Mining Reveals Abundant Uncharacterized Transporters In Coccidioides Immitis And Coccidioides Posadasii, Hong Cai, Hao Zhang, Daniel H. Guo, Yufeng Wang, Jianying Gu

Publications and Research

Coccidioides immitis and Coccidioides posadasii are causative agents of coccidioidomycosis, commonly known as Valley Fever. The increasing Valley Fever cases in the past decades, the expansion of endemic regions, and the rising azole drug-resistant strains have underscored an urgent need for a better understanding of Coccidioides biology and new antifungal strategies. Transporters play essential roles in pathogen survival, growth, infection, and adaptation, and are considered as potential drug targets. However, the composition and roles of transport machinery in Coccidioides remain largely unknown. In this study, genomic data mining revealed an abundant, uncharacterized repertoire of transporters in Coccidioides genomes. The catalog …

Update On Monkeypox, Audra E. Haynes, Susan H. Davide, Anty Lam

Publications and Research

Monkeypox a viral transmissible disease caused by the monkeypox virus, a disease commonly found in Central and Western Africa, has caused a recent outbreak of monkeypox in the United States. Highlighting the importance of dental healthcare professionals to become knowledgeable about the transmission of the disease, and how to better protect themselves and the public from further spread, as well as educating patients about the disease.

This review examines the etiology of monkeypox, transmission, signs and symptoms, and preventive measures to reduce occurrence of the disease with an emphasis on who has largely been affected by the disease and the …

Prenatal Choline Supplementation During Maternal Obesity Alters Offspring Response To Western Diets, Hunter W. Korsmo

Dissertations, Theses, and Capstone Projects

Maternal obesity has led to an increase in adverse offspring developmental outcomes and a greater risk for long-term metabolic diseases. Choline, a semi-essential nutrient, can be incorporated into phosphatidylcholine (PC) as well as sphingomyelin (SM) and donate its labile methyl group for the remethylation of homocysteine after choline is oxidized to betaine. Prenatal choline insufficiency has been related to maternal obesity and metabolic diseases, such as metabolic associated fatty liver disease (MAFLD). Choline may interact with maternal obesity to influence the programming offspring.

Chapter 1 presents an introduction of choline and the various clinical outcomes associated with choline supplementation during …

Function Of Atm And Msh2 During Dna Repair And Recombination, Emily Sible

Dissertations, Theses, and Capstone Projects

Class switch recombination (CSR) produces secondary immunoglobulin isotypes and requires AID-dependent DNA deamination of intronic switch (S) regions within the immunoglobulin heavy chain (Igh) gene locus. Non-canonical repair of deaminated DNA by mismatch repair (MMR) or base excision repair (BER) creates DNA breaks that permit recombination between distal S regions. ATM-dependent phosphorylation of AID at serine-38 (pS38-AID) promotes its interaction with APE1, a BER protein, suggesting that ATM regulates CSR through BER. However, pS38-AID may also function in MMR during CSR, although the mechanism remains unknown. To examine whether ATM modulates BER- and/or MMR-dependent CSR, Atm^-/- mice …

The Making Of A Bilingual University In The 21st Century, Michael Mena

Dissertations, Theses, and Capstone Projects

At the southernmost tip of Texas, the University of Texas Rio Grande Valley (UTRGV) opened its doors on August 31, 2015 as a ‘bilingual, bicultural, and biliterate’ campus—the only one of its kind and at a scale never before attempted in the United States. This is a categorical achievement in the near 200 year-long quest for the educational advancement of Latinxs in Texas—a state historically structured by white supremacist ideologies, violent economic and political disenfranchisement, as well as a racially segregated education system designed to maintain exploitative labor practices (Montejano 1987; González 1990, 2013, 1999; Blanton 2004). This constitutes the …

Understanding Distruptive Change In Health Care: Perspectives From The Front Lines Of Covid, Wendy Vaughon

Dissertations and Theses

COVID-19 dramatically stressed an already overburdened healthcare system. Physicians, susceptible to burnout, bore the brunt of this threat as frontline providers. Limited data are available describing how the pandemic may have affected physician perceptions and beliefs, including experiences of burnout and plans to exit the field. Reddit, a social media website, allows physicians the ability to interact with their peers pseudonymously on a purpose-driven, publicly viewable subreddit (r/medicine). By providing a space for “physicians and other medical professionals” to interact, it is possible to observe unfiltered discourse.

This dissertation explores physician-peer discourse on Reddit prior to and during the COVID-19 …

Generation Of Mycobacterium Smegmatis Model Systems For Testing Inhibitors Of The Mycobactin Siderophore Of Mycobacterium Tuberculosis, Gabrielle A. Germain

Dissertations, Theses, and Capstone Projects

Mycobacterium tuberculosis (Mtb) is the pathogenic bacterium causative of tuberculosis. According to the 2021 World Health Organization (WHO) Global Tuberculosis (TB) Report, there were approximately 5.8 million TB cases in 2020, and 1.3 million TB deaths among HIV negative people in that year. The rise of multi-drug resistant Mtb strains has increased the need for more potent microbials against this pathogen. Biosynthesis of iron scavenging molecules, known as siderophores (e.g., mycobactin and carboxymycobactin), has been identified as a potential drug target candidate since iron acquisition has been directly linked to the survival and virulence of Mtb. Salicyl-AMS (Sal-AMS) is …

A Decade Review Of Disease Surveillance Research Trends In The International Journal Of Health Geographics (2009 To 2018), Rose Jimenez, Paradorn Wongchanapai

Publications and Research

The field of health geographics is rapidly growing in its methods and epistemologies. This is a review of the open-source journal International Journal of Health Geographics, and the trends in disease surveillance over ten years (2009-2018). Drawing from research review methodologies, we wrote a Python script to quantify research trends within the field of geographic disease surveillance, finding many articles focusing on population health, techniques of GIS, qualitative techniques, and geospatial technology for health monitoring. This was foundational in conducting an in-depth qualitative lexical analysis of article content and epistemologies. Overall, we concluded that over the time period, the …

Community Engagement Education In Academic Health Centers, Colleges, And Universities, Chyke A. Doubeni, David Nelson, Elizabeth Gross Cohn, Electra Paskett, Seleshi Ayalew Asfaw, Mehek Sumar, Syed M. Ahmed, Rhonda Mcclinton-Brown, Mark L. Wieland, Anita Kinney, Sergio Aguilar-Gaxiola, Lisa G. Rosas, Cecilia M. Patino

Publications and Research

Community engagement (CE) is critical for advancing health equity and a key approach for promoting inclusive clinical and translational science. However, it requires a workforce trained to effectively design, implement, and evaluate health promotion and improvement strategies through meaningful collaboration with community members. This paper presents an approach for designing CE curricula for research, education, clinical care, and public health learners. A general pedagogical framework is presented to support curriculum development with the inclusion of community members as facilitators or faculty. The overall goal of the curriculum is envisioned as enabling learners to effectively demonstrate the principles of CE in …

The Experiences Of Older Formerly Incarcerated Adults In A Specialized Reentry Program During The Covid-19 Pandemic, Robin O'Hanlon, Jessica Broome

Publications and Research

A growing area of concern among prison reform advocates and human rights activists is the “greying prison population” or the continuous, unified growth in the number of older incarcerated individuals. Older individuals experience an accelerated aging process while incarcerated, but are less likely to reoffend upon release. While the aging prison population has in recent years become a focus of criminological and gerontological scholars, the lived experience of older formerly incarcerated individuals during the reentry process remains understudied. Using a qualitative approach, this cohort study seeks to further elucidate the unique needs, beliefs, and perceptions of this population within the …

Medical Avoidance Among Marginalized Groups: The Impact Of The Covid‑19 Pandemic, Amani R. Holder‑Dixon, Olivia R. Adams, Tianna L. Cobb, Alison J. Goldberg, Rachel A. Fikslin, Mora A. Reinka, Amanda N. Gesselman, Devon M. Price

Publications and Research

Medical avoidance is common among U.S. adults, and may be emphasized among members of marginalized communities due to discrimination concerns. In the current study, we investigated whether this disparity in avoidance was maintained or exacerbated during the onset of the COVID-19 pandemic. We assessed the likelihood of avoiding medical care due to general-, discrimination-, and COVID-19-related concerns in an online sample ( N = 471). As hypothesized, marginalized groups (i.e., non-White race, Latinx/e ethnicity, non-heterosexual sexual orientation, high BMI) endorsed more general- and discrimina - tion-related medical avoidance than majoritized groups. However, marginalized groups were equally likely to seek COVID-19 …

Borders: A Story Of Political Imagination, Miriam Ticktin

Publications and Research

This article traces three different political imaginaries about borders, suggesting that the dominant imaginary—the one of border walls, driven by a fear of invasion—is only one way to live in the world. The goal is to make space in our political imaginations to rethink how we live together, including thinking beyond nation-states as containers that keep people in or out. By first showing how the vision of invasion is built and maintained with intersecting transnational technologies and ideologies, I open the way to thinking otherwise. Second, I trace the counterpolitics of borders developed by artists and activists, resisting borders and …

The Cost Of Living In Larger Primate Groups Includes Higher Fly Densities, Jan F. Gogarten, Mueena Jahan, Sébastien Calvignac-Spencer, Colin A. Chapman, Tony L. Goldberg, Fabian H. Leendertz, Jessica M. Rothman

Publications and Research

Flies are implicated in carrying and mechanically transmitting many primate pathogens. We investigated how fly associations vary across six monkey species (Cercopithecus ascanius, Cercopithecus mitis, Colobus guereza, Lophocebus albigena, Papio anubis, and Piliocolobus tephrosceles) and whether monkey group size impacts fly densities. Fly densities were generally higher inside groups than outside them, and considering data from these primate species together revealed that larger groups harbored more flies. Within species, this pattern was strongest for colobine monkeys, and we speculate this might be due to their smaller home ranges, suggesting that movement patterns may influence fly–primate associations. Fly associations increase with …

Radiation Isolation And The Impact Of Care: Nursing Knowledge And Perception Of Radiation Risks, Bae P. Chu

Dissertations and Theses

Background: The safety challenges encountered when employing ionizing radiation to treat patients and manage radiation exposure and contamination have been well established in previous research. However, little is known about nurses’ understanding of the risks associated with ionizing radiation and how they respond to their own perceptions of risk. Although a wealth of literature shows an association between radiation treatment and negative patient experiences, there remains a lack of understanding of the basis of these perceptions among nurses. Increased ionizing radiation diagnoses and treatment means that nurses are at a higher risk of radiation exposure today than thirty years ago. …

Genomic Insights Into Mechanisms Of Microbial Evolution And Evolution-Inspired Strategies To Combat Pathogen Diversity, Saymon Akther

Dissertations, Theses, and Capstone Projects

We live in an era of emerging infectious diseases that are increasingly common, rapidly spreading, and gravely devastating. Lyme disease, caused by bacteria belonging to the genus Borreliella, is rapidly rising in the Northern Hemisphere because of geographic range expansion of both the tick vectors and the pathogens. Evolutionary comparative analysis of Borreliella genomes is a key to understanding the phylogeographic history and mechanisms of their global diversification. Moreover, genomic variations in Borreliella associated with human pathogenicity, e.g., at loci encoding cell-surface antigens interacting with the vertebrate hosts, have not been fully identified. Similarly, the ongoing COVID-19 pandemic, caused …