Digital Commons Network^™

Quantification Of Hiv-1 Rna Among Men Who Have Sex With Men Using An At-Home Self-Collected Dried Blood Spot Specimen: Feasibility Study, Sabina Hirshfield, Richard A. Teran, Martin J. Downing Jr., Mary Ann Chiasson, Hong-Van Tieu, Laura Dize, Charlotte A. Gaydos

Publications and Research

Background: Suboptimal antiretroviral therapy (ART) adherence and disengagement in care present significant public health challenges because of the increased probability of HIV transmission. In the United States, men who have sex with men (MSM) continue to be disproportionately affected by HIV, highlighting a critical need to engage high-risk MSM living with HIV who are not engaged or retained in care.

Objective: The aim of the study was to assess the feasibility of at-home blood self-collection and laboratory quantification of HIV-1 RNA viral load (VL) to report laboratory-based VL outcomes and compare self-reported and laboratory-reported VL

Methods: Between 2016 and 2017, …

Reducing Arsenic Exposure From Private Well Water In The United States: The Use, Effect, And Potential Of Testing Requirements, Sara Flanagan

Dissertations and Theses

Over 45 million Americans drink from unregulated private well water of unknown quality. Arsenic is the most concerning groundwater contaminant for health because of its toxicity and widespread natural occurrence. Most residential wells in arsenic-affected areas have not been tested for arsenic; the success of community programs and efforts to motivate testing is limited by a range of psychological, situational, and socioeconomic barriers. However, testing only acts as screening and does not reduce exposure without effective and consistent actions to follow. Given the limitations in relying on individual well owners to be aware, willing, and capable of testing their water, …

Bone Marrow Derived Progenitor Cells And Their Contributions To The Thymic Stroma, Mohammed Hoque

Dissertations and Theses

The thymus serves as the primary lymphoid organ responsible for the development and selection of a self-tolerant T cell repertoire. In paradox to its critical functions for the adaptive immune response, the thymus undergoes a profound age associated decline beginning in early adult life resulting in significant decline in T-cell function.Thymic epithelial cells (TECs) are the most critical component of the thymic microenvironment and undergo rapid turn-over, so understanding the cellular mechanisms responsible for the maintenance of TEC number and organization will be critical in counteracting age associated involution, particularly in cancer patients, due to enhanced degeneration in response to …

Well-Being And Academic Performance In Immigrant Students: The Role Of Inequality Of Country Of Origin And Resilience, Yumiko Yamaguchi

Dissertations and Theses

Abstract

Research on the psychology of immigrants has primarily focused on their socioeconomic status, but has not factored in macroeconomic indicators. These provide a deeper understanding of the stressors experienced by immigrants through the lens of cultural gaps between home and host countries. This study examined predictors of psychological well-being (PWB) and academic performance among 376 immigrant college students by employing Bronfenbrenner’s bioecological model of development (1994) consisting of four levels of environmental factors: Macrosystem, exosystem, mesosystem and microsystem. The results revealed that higher PWB was predicted by mesosystem variables (lower perceived stress, lower acculturative stress) and microsystem variables (higher …

Adolescent Medicine Trials Network For Hiv/Aids Interventions Data Harmonization: Rationale And Development Of Guidelines, Micah Mccumber, Demetria Cain, Sara Legrand, Kenneth H. Mayer, Debra A. Murphy, Matthew A. Psioda, Arlene C. Seña, Tyrel J. Starks, Michael Hudgens

Publications and Research

Background: The Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) research program aims to defeat the rising HIV epidemic among adolescents and young adults in the United States.

Objective: This study aims to optimize cross-study analyses and comparisons of standardized measures (variables) collected in the ATN. Methods: Guidelines were developed for harmonizing measures to be collected across ATN studies.

Results: Eight domains were identified for harmonization—Demographics and Socioeconomic Characteristics, Sexual Behavior and Risk, Substance Use and Abuse, HIV-Positive Cascade, HIV-Negative Cascade, Mental Health, Social Support and Isolation, and Pre-exposure Prophylaxis Cascade.

Conclusions: The collection of selected key measures in a …

“We Hide…”: Perceptions Of Hiv Risk Among Black And Latino Msm In New York City, Ashley Murray, Zaneta Gaul, Madeline Y. Sutton, Jose Nanin

Publications and Research

Black and Latino men who have sex with men (BLMSM) are disproportionately infected with HIV; they comprised 66% of HIV diagnoses among men who have sex with men (MSM) in the United States in 2015. Risk factors for HIV infection among BLMSM include a high community prevalence of diagnosed and undiagnosed HIV/STDs, and dense sex partner networks. Perceptions of HIV risk among BLMSM were explored to inform HIV prevention efforts. During 2011–2012, semistructured interviews were conducted with BLMSM in New York City. Using computer-assisted thematic analyses (NVivo), transcribed interview responses to questions regarding HIV risk for main themes were examined. …

Proceedings Of The Cuny Games Conference 4.0: The Interactive Course, Robert O. Duncan, Joe Bisz, Julie Cassidy, Kathleen Offenholley, Maura A. Smale, Carolyn Stallard, Deborah Sturm, Anders A. Wallace, Cuny Games Network

Publications and Research

Proceedings of the CUNY Games Conference, held from January 22-23, 2018, at the CUNY Graduate Center and Borough of Manhattan Community College.

Critical Play with History (Panel) - Composition & Storytelling - Health & Cognitive Sciences - Gaming Anthropology: Teaching Culture and Power Through Games and Design (Panel) - Twine & Writing Games - Easy Ideas II - STEM Games - Global Games for Change Catalog (Panel) - Comics & Active Learning - Fact Checking & Research - Computer Science & Game Design - SimGlobal: Building a Serious Roleplay Course for the Social Sciences (Panel) - Role Playing Games, Narrative, …

Home-Based Pre-Exposure Prophylaxis (Prep) Services For Gay And Bisexual Men: An Opportunity To Address Barriers To Prep Uptake And Persistence, Steven A. John, H Jonathon Rendina, Christina Grov, Jeffrey T. Parsons

Publications and Research

Gay, bisexual, and other men who have sex with men (GBM) are disproportionately affected by the HIV epidemic. Despite the promise of pre-exposure prophylaxis (PrEP) in reducing HIV transmission risk, barriers for uptake and persistence exist. We sought to identify whether GBM in a nationwide cohort who have not yet initiated PrEP (n = 906) would prefer to get PrEP-related care from a primary care provider (PCP) compared to a specialist clinic or provider. We then sought to identify their level of interest and factors associated with preference for using home-based PrEP services (i.e., HB-PrEP), defined to participants as conducting …

Mode Of Delivery And Child And Adolescent Psychological Well-Being: Evidence From Hong Kong’S “Children Of 1997” Birth Cohort, Cherry Y. Leung, Gabriel M. Leung, C. Mary Schooling

Publications and Research

Mode of delivery (vaginal or cesarean section) is thought to affect gut microbiota, which in turn may affect psychological well-being. As such, mode of delivery is potentially a modifiable factor for psychological well-being. Here we examined the association of mode of delivery with child and adolescent psychological well-being. We used multivariable linear regression in a populationrepresentative Hong Kong Chinese birth cohort, “Children of 1997,” to examine the adjusted associations of mode of delivery with behavioral problems assessed from parent-reported Rutter score at ~7 (n = 6294) and ~11 years (n = 5598), self-esteem assessed from self-reported Culture-Free Self- Esteem Inventory …

Nlrp10 Enhances Cd4+ T-Cell-Mediated Ifnγ Response Via Regulation Of Dendritic Cell-Derived Il-12 Release, Maurizio Vacca, Julia Böhme, Lisa Zambetti, Hanif Javanmard Khameneh, Bhairav S. Paleja, Federica Laudisi, Adrian W. S. Ho, Kurt Neo, Keith Weng Kit Leong, Mardiana Marzuki, Bernett Lee, Michael Poidinger, Laura Santambrogio, Liana Tsenova, Francesca Zolezzi, Gennaro De Libero, Amit Singhal, Alessandra Mortellaro

Publications and Research

NLRP10 is a nucleotide-binding oligomerization domain-like receptor that functions as an intracellular pattern recognition receptor for microbial products. Here, we generated a Nlrp10−/− mouse to delineate the role of NLRP10 in the host immune response and found that Nlrp10−/− dendritic cells (DCs) elicited sub-optimal IFNγ production by antigenspecific CD4+ T cells compared to wild-type (WT) DCs. In response to T-cell encounter, CD40 ligation or Toll-like receptor 9 stimulation, Nlrp10−/− DCs produced low levels of IL-12, due to a substantial decrease in NF-κB activation. Defective IL-12 production was also evident in vivo and affected IFNγ production by CD4+ T cells. Upon …

Needle Acquisition Patterns, Network Risk And Social Capital Among Rural Pwid In Puerto Rico, Ian Duncan, Patrick Habecker, Roberto Abadie, Ric Curtis, Bilal Khan, Kirk Dombrowski

Publications and Research

Background: People who inject drugs (PWID) take on significant risks of contracting blood-borne infection, including injecting with a large number of partners and acquiring needles from unsafe sources. When combined, risk of infection can be magnified.

Methods: Using a sample of PWID in rural Puerto Rico, we model the relationship between a subject’s number of injection partners and the likelihood of having used an unsafe source of injection syringes. Data collection with 315 current injectors identified six sources of needles.

Results: Of the six possible sources, only acquisition from a seller (paid or free), or using syringes found on the …

Structural And Biochemical Studies Of The Dna Replication Initiation Mechanism Of The Second Chromosome Of Vibrio Cholerae, Natalia Orlova

Dissertations, Theses, and Capstone Projects

Transmission of genetic information through DNA replication is one of the key processes for any living organism. Despite the extensive effort put into studies of the mechanism of DNA replication, the understanding of the process on the molecular level is still incomplete. Specifically the molecular details of the very first events of DNA replication initiation are not sufficiently understood.

The majority of bacteria possess a single circular chromosome, and in order to initiate DNA replication these organisms utilize a conserved system, consisting of a specific DNA sequence - replication origin, called oriC, and replication initiator protein DnaA. However, bacteria …

Design And Revision Of An Open-Educational Resource Microbiology Lab Manual Using Student Feedback, Joan Petersen, Susan K. Mclaughlin

Publications and Research

Open educational resources are becoming increasingly important in higher education, and are a valuable resource for instructors who want to customize course content while saving their students money. We designed, revised, and assessed an open educational resource for our Principles of Microbiology course. Student feedback was used to guide the revisions, which took place over the course of several semesters. Student survey responses to lab manual content were very positive, and students overwhelmingly favored a no-cost online manual over one that is commercially published. The process we used to develop this lab manual serves as an example for others who …

The End Of Aids: Gender, Race And Class Politics In New York's Campaign To End The Epidemic, Lauren Suchman

Dissertations, Theses, and Capstone Projects

Since its official discovery in 1981, the story of HIV/AIDS has been a story of inequality. Not only has the virus spread more easily among those marginalized due to their gender, race, or class, but AIDS activism itself has tended to elevate the voices and needs of the more powerful over those with less privilege. While we might point to 1981, when the CDC issued its first official report on HIV, as the official “beginning” of HIV/AIDS, where and how does the story end? This dissertation examines one attempt to bring the story to a close: New York State’s “Ending …

Trypanosome Lytic Factor Mediated Immunity Against Leishmania Sp., Jyoti Pant

Dissertations, Theses, and Capstone Projects

Trypanosome Lytic Factor (TLF) is an innate immunity complex that was originally discovered to protect against African Trypanosomes. The major components of TLF are Apolipoprotein A1 (APOA1), Apolipoprotein L1 (APOL1) and HPR (Haptoglobin Related Protein), where APOL1 is necessary and sufficient for trypanolysis. Recently we have shown that TLF ameliorates infections by cutaneous Leishmania species. Here we investigated the effect of different primate and human TLF against different Leishmania sp. Our result shows that TLF kills metacyclic promastigotes of cutaneous Leishmania sp. within immune cells such as neutrophils and macrophages by two different mechanism. Using transiently transfected and germline transgenic …

An Investigation Of Public Injection Drug Use In New York City: A Mixed-Methods Study, Taeko M. Frost

Dissertations and Theses

Background: Drug use and injection-related harms are on the rise in the United States (US). As a result, new outbreaks of HIV and viral hepatitis C (HCV) attributed to injection drug use have been identified across the country. In addition to HIV and HCV, skin and soft tissue infection (SSTIs) that result from risky injection practices lead to preventable and costly emergency department (ED) visits. The concurrent opioid overdose epidemic has prompted a national conversation on how to effectively address drug-related harms and associated costs. International studies have identified that the place a person injects is related to adverse health …

Trends In Hpv Vaccine Initiation And Completion Among Girls In Texas: Behavioral Risk Factor Surveillance System Data, 2008–2010, Tatjana Gazibara, Haomiao Jia, Erica I. Lubetkin

Publications and Research

Objective: The objective of this study was to evaluate the trend of HPV vaccine initiation and completion among girls in Texas from 2008 to 2010.

Methods: Data were obtained from the Behavioral Risk Factors Surveillance System (BRFSS) over 3 years (2008–2010). The information regarding HPV vaccination was gathered from the parents of 9- to 17-year-old daughters (choosing only 1 per household) in randomly selected households in the sample area.

Results: The highest prevalence of vaccine initiation and completion were detected in 2010 (20.9% and 9.7%, respectively). Over the study period, HPV vaccine initiation statistically significantly increased (2008, 14.9%; 2009, 20.7%; …

Engineered Aptamers To Probe Molecular Interactions On The Cell Surface, Sana Batool, Sanam Bhandari, Shanell George, Precious Okeoma, Nabeela Van, Hazan E. Zümrüt, Prabodhika Mallikaratchy

Publications and Research

Significant progress has been made in understanding the nature of molecular interactions on the cell membrane. To decipher such interactions, molecular scaffolds can be engineered as a tool to modulate these events as they occur on the cell membrane. To guarantee reliability, scaffolds that function as modulators of cell membrane events must be coupled to a targeting moiety with superior chemical versatility. In this regard, nucleic acid aptamers are a suitable class of targeting moieties. Aptamers are inherently chemical in nature, allowing extensive site-specific chemical modification to engineer sensing molecules. Aptamers can be easily selected using a simple laboratory-based in …

Glycomics For Microbes And Microbiologists, Peter N. Lipke

Publications and Research

The recent article “Lectin-Glycan Interaction Network-Based Identification of Host Receptors of Microbial Pathogenic Adhesins” by Ielasi et al. describes a new development in microbial carbohydrate analysis [Ielasi FS, Alioscha-Perez M, Donohue D, Claes S, Sahli H, Schols D, Willaert RG, mBio 7(4):e00584-16, 2016, http://dx.doi.org/10.1128/mbio.00584-16]. Specific carbohydrate ligands have been identified from the patterns of lectin binding to oligosaccharides printed on a chip. The new technique links the output to a comprehensive glycan database and offers a number of data visualization options. The graphs highlight the occurrence of potential ligands, organized by organism, tissue, and patterns of association with disease states. …

The New York City Childcare Influenza Vaccine Mandate: A Case Study, Amy E. Metroka

Dissertations and Theses

Background. In 2014, New York City (NYC) became the third jurisdiction in the United States (US) to enact a childcare influenza vaccine mandate, after the states of New Jersey and Connecticut. The mandate was enacted by the NYC Board of Health by amending the NYC Health Code. The mandate’s goal was to increase vaccination rates among 6-59-month-olds attending city-regulated public and private childcare programs, including prekindergarten, to protect children, families, and the community against influenza. Children younger than 5 years are at high risk for severe illness and complications from influenza. Children are also known to be a major source …

Swords Into Ploughshares: Agricultural Recovery And Postwar Institutional Development In Sub-Saharan Africa, Jinu R. Abraham

Dissertations, Theses, and Capstone Projects

Civil wars have long been characterized in the comparative politics literature as having profoundly negative economic effects for both individual households and countries on a larger scale. However, variation in postwar economic outcomes indicates that conflict may indeed have some curative effects. I argue political settlements in the aftermath of civil wars can shape postwar economic outcomes by transforming institutions critical to agricultural productivity. The structure of the state postwar can shape land tenure security, local government participation, and the management of preexisting social divisions. I employ a case study method controlling for differences on the independent variable in order …

Transitional Healthcare Coordination In New York City Jails Among People With Chronic Health Conditions: Contributions To Reduced Reincarceration And Improved Health, Janet J. Wiersema

Dissertations and Theses

People in correctional settings often have poorer health than the general US population. For example, it is estimated that 27.9% of persons in jail have hypertension, 8.1% have diabetes, and 1.6% have HIV, compared to 25.6%, 6.5%, and 0.5%, respectively, in the general population. Jail and other correctional settings are also increasingly recognized as viable places to engage poor and underserved communities into the healthcare system by offering transitional care coordination services to connect people to healthcare and other services to meet priorities after incarceration. At the same time, recidivism is an issue—over 50% of persons in New York City …

Post-9/11 Media Coverage Of Terrorism, Zachary S. Mitnik

Student Theses

Media coverage of terrorist attacks plays an important role in shaping the public understanding of terrorism. While there have been several studies analyzing coverage of terrorist incidents prior to 9/11, there has been little research examining post-9/11 coverage. This study fills this gap by examining the media’s coverage of terrorism in the United States between the dates of September 12, 2001 and December 31, 2015. The analysis is based on a list of terrorist-related incidents and New York Times articles written on each incident. This study documents the amount of coverage received by these incidents and identifies the variables influencing …

Synchronized And Mixed Outbreaks Of Coupled Recurrent Epidemics, Muhua Zheng, Ming Zhao, Byungjoon Min, Zonghua Liu

Publications and Research

Epidemic spreading has been studied for a long time and most of them are focused on the growing aspect of a single epidemic outbreak. Recently, we extended the study to the case of recurrent epidemics (Sci. Rep. 5, 16010 (2015)) but limited only to a single network. We here report from the real data of coupled regions or cities that the recurrent epidemics in two coupled networks are closely related to each other and can show either synchronized outbreak pattern where outbreaks occur simultaneously in both networks or mixed outbreak pattern where outbreaks occur in one network but do not …

Offering Self-Administered Oral Hiv Testing As A Choice To Truck Drivers In Kenya: Predictors Of Uptake And Need For Guidance While Self-Testing, Elizabeth A. Kelvin, Gavin George, Eva Mwai, Eston N. Nyaga, Joanne E. Mantell, Matthew L. Romo, Jacob O. Odhiambo, Kaymarlin Govender

Publications and Research

We assessed predictors of choosing self-administered oral HIV testing in the clinic with supervision versus the standard provider-administered blood test when offered the choice among 149 Kenyan truck drivers, described the types of guidance participants needed during self-testing and predictors of needing guidance. Overall, 56.38% of participants chose the self-test, 23.49% the provider-administered test, and 20.13% refused testing. In the adjusted regression models, each additional unit on the fatalism and self-efficacy scales was associated with 0.97 (p = 0.003) and 0.83 (p = 0.008) times lower odds of choosing the self-test, respectively. Overall, 52.38% of self-testers did so correctly without …

Alternatives To Pretrial Detention:Pre Global Best Practice Catalog, Jerry Cho, Sara Cronqvist, Sara Curran, Laura Galeano, Camila Jimenez Lugo, Alexandra Lynn, Weronika Kozyra, Justyna Maksimiuk, Suchaya Mokkhasen, Kelly Ortega, Kartika Rahman, Ashley Roman

Publications and Research

This Global Best Practice Catalog of Alternatives to Pretrial Detention was completed by students of the Master of Arts Degree Program in International Crime and Justice at John Jay College of Criminal Justice as part of their capstone course, in collaboration with the US State Department's Diplomacy Lab program. This catalog is intended to cover best practices in reducing pretrial detention (either before it occurs or while it is occurring) across the globe, including laws, policies and programs. It does not include Oceania or very detailed information on North America. Each entry meets 5 of 8 criteria below, as decided …

What Does Silence = Now? An Analysis Of Past And Present Discourse Surrounding Hiv/Aids, Emily A. Moner

Theses and Dissertations

This essay examines how the HIV/AIDS epidemic was first addressed in the context of politics, media and the general public and subsequently how that compares to the ways in which it’s currently being discussed using popular forms of communication such as Facebook, Twitter and other forms of social media.

African Wild Dog, Lycaon Pictus, Coloration Patterns And Social Aggregation, Ayong J. Kim

Theses and Dissertations

Packs of African wild dogs, Lycaon pictus, were analyzed for coloration patterns and social aggregation tendencies. Mapped locations determined if the coat patterns followed a geographic distribution that corresponded to Southern or Eastern phenotypic forms. Social aggregation tendencies were observed to determine grouping behavior presumably related to individuals’ roles.

Zika Virus-Like Particle (Vlp) Based Vaccine, Héléne Boigard, Alexandra Alimova, George R. Martin, Al Katz, Paul Gottlieb, Jose M. Galarza

Publications and Research

The newly emerged mosquito-borne Zika virus poses a major public challenge due to its ability to cause significant birth defects and neurological disorders. The impact of sexual transmission is unclear but raises further concerns about virus dissemination. No specific treatment or vaccine is currently available, thus the development of a safe and effective vaccine is paramount. Here we describe a novel strategy to assemble Zika virus-like particles (VLPs) by co-expressing the structural (CprME) and non-structural (NS2B/NS3) proteins, and demonstrate their effectiveness as vaccines. VLPs are produced in a suspension culture of mammalian cells and self-assembled into particles closely resembling Zika …

Worldwide Use Of Triclosan: Can Dentistry Do Without This Antimicrobial?, Diana V. Macri

Publications and Research

No abstract provided.