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Role For Sumoylation In Systemic Inflammation And Immune Homeostasis In Drosophila Larvae, Indira Paddibhatla, Mark J. Lee, Marta E. Kalamarz, Roberto Ferrarese, Shubha Govind

Publications and Research

To counter systemic risk of infection by parasitic wasps, Drosophila larvae activate humoral immunity in the fat body and mount a robust cellular response resulting in encapsulation of the wasp egg. Innate immune reactions are tightly regulated and are resolved within hours. To understand the mechanisms underlying activation and resolution of the egg encapsulation response and examine if failure of the latter develops into systemic inflammatory disease, we correlated parasitic wasp-induced changes in the Drosophila larva with systemic chronic conditions in sumoylation-deficient mutants. We have previously reported that loss of either Cactus, the Drosophila (IkB) protein or Ubc9, the SUMO-conjugating …

Earlier Buddhist Theories Of Free Will: Compatibilism, Rick Repetti

Publications and Research

This is the first part of a three-article series that examines Budd-hist accounts of free will. The present article introduces the issues and reviews earlier attempts by Frances Story, Walpola Rāhula, Luis Gómez, and David Kalupahana. These “early-period” authors advocate compatibilism between Buddhist doctrine, determinism (the doctrine of universal lawful causation), and free will. The second article reviews later attempts by Mark Siderits, Gay Watson, Joseph Goldstein, and Charles Goodman. These “middle-period” authors embrace either partial or full incompatibilism. The third article reviews recent attempts by Nicholas F. Gier and Paul Kjellberg, Asaf Federman, Peter Harvey, and B. Alan Wallace. …

Liquid-Liquid Phase Transition And Glass Transition In A Monoatomic Model System, Limei Xu, Sergey V. Buldyrev, Nicolas Giovambattista, H. Eugene Stanley

Publications and Research

We review our recent study on the polyamorphism of the liquid and glass states in a monatomic system, a two-scale spherical-symmetric Jagla model with both attractive and repulsive interactions. This potential with a parametrization for which crystallization can be avoided and both the glass transition and the liquid-liquid phase transition are clearly separated, displays water-like anomalies as well as polyamorphism in both liquid and glassy states, providing a unique opportunity to study the interplay between the liquid-liquid phase transition and the glass transition. Our study on a simple model may be useful in understanding recent studies of polyamorphism in metallic …

“Did You Call Me?” 5-Month-Old Infants Own Name Guides Their Attention, Eugenio Parise, Angela D. Friederici, Tricia Striano

Publications and Research

An infant's own name is a unique social cue. Infants are sensitive to their own name by 4 months of age, but whether they use their names as a social cue is unknown. Electroencephalogram (EEG) was measured as infants heard their own name or stranger's names and while looking at novel objects. Event related brain potentials (ERPs) in response to names revealed that infants differentiate their own name from stranger names from the first phoneme. The amplitude of the ERPs to objects indicated that infants attended more to objects after hearing their own names compared to another name. Thus, by …

A Microfluidic Device To Establish Concentration Gradients Using Reagent Density Differences, Qingjun Kong, Richard A. Able, Jr., Veronica Dudu, Maribel Vazquez

Publications and Research

Microfabrication has become widely utilized to generate controlled microenvironments that establish chemical concentration gradients for a variety of engineering and life science applications. To establish microfluidic flow, the majority of existing devices rely upon additional facilities, equipment, and excessive reagent supplies, which together limit device portability as well as constrain device usage to individuals trained in technological disciplines. The current work presents our laboratory-developed bridged microLane system, which is a stand-alone device that runs via conventional pipette loading and can operate for several days without need of external machinery or additional reagent volumes. The bridged microLane is a two-layer polydimethylsiloxane …

Sex Partnerships, Health, And Social Risks Of Young Men Leaving Jail: Analyzing Data From A Randomized Controlled Trial, Megha Ramaswamy, Nicholas Freudenberg

Publications and Research

Background Young men involved in the criminal justice system face disproportionately high rates of sexual risk behavior, drug, use, and violence. Little is known about how their involvement in sex partnerships might mitigate their unique health and social risks. This study explores whether sex partner experience protects against harmful sexual behaviors, drug problems, violence, and recidivism in 16-18-year-old Black and Latino men leaving a US jail. Methods Data were drawn from the Returning Educated African-American and Latino Men to Enriched Neighborhoods (REAL MEN) study conducted between 2003-2007, which tracked 552 adolescents during their time in a New York City jail …

The Communicator, November 8, 2010, Bronx Community College

The Communicator

The Communicator newspaper published on November 8, 2010.

The Mycobacterium Tuberculosis Drugome And Its Polypharmacological Implications, Sarah L. Kinnings, Li Xie, Kingston H. Fung, Richard M. Jackson, Lei Xie, Phillip E. Bourne

Publications and Research

We report a computational approach that integrates structural bioinformatics, molecular modelling and systems biology to construct a drug-target network on a structural proteome-wide scale. The approach has been applied to the genome of Mycobacterium tuberculosis (M.tb), the causative agent of one of today’s most widely spread infectious diseases. The resulting drug-target interaction network for all structurally characterized approved drugs bound to putative M.tb receptors, we refer to as the ‘TB-drugome’. The TB-drugome reveals that approximately one-third of the drugs examined have the potential to be repositioned to treat tuberculosis and that many currently unexploited M.tb receptors may be chemically druggable …

Ealles Englalandes Cyningc: Cnut's Territorial Kingship And Wulfstan's Paronomastic Play, Paul Gates

Publications and Research

The phrase ealles Englalandes cyningc appears for the first time in I–II Cnut, and represents a shift in the discourse of Anglo-Saxon kingship, changing it from king over a people to king over a territory, redefining the discourse of nationhood.

Tensorial Reconstruction At The Integrand Level, G. Heinrich, Giovanni Ossola, T. Reiter, F. Tramontano

Publications and Research

We present a new approach to the reduction of one-loop amplitudes obtained by reconstructing the tensorial expression of the scattering amplitudes. The reconstruction is performed at the integrand level by means of a sampling in the integration momentum. There are several interesting applications of this novel method within existing techniques for the reduction of one-loop multi-leg amplitudes: to deal with numerically unstable points, such as in the vicinity of a vanishing Gram determinant; to allow for a sampling of the numerator function based on real values of the integration momentum; to optimize the numerical reduction in the case of long …

A New Mouse Model To Explore Therapies For Preeclampsia, Abdulwahab Ahmed, Jameel Singh, Ysodra Khan, Surya V. Seshan, Guillermina Girardi

Publications and Research

Background Pre-eclampsia, a pregnancy-specific multisystemic disorder is a leading cause of maternal and perinatal mortality and morbidity. This syndrome has been known to medical science since ancient times. However, despite considerable research, the cause/s of preeclampsia remain unclear, and there is no effective treatment. Development of an animal model that recapitulates this complex pregnancy-related disorder may help to expand our understanding and may hold great potential for the design and implementation of effective treatment. Methodology/Principal Findings Here we show that the CBA/J x DBA/2 mouse model of recurrent miscarriage is also a model of immunologically-mediated preeclampsia (PE). DBA/J mated CBA/J …

An Application Of Statistical Technique To Correct Satellite Data Due To Orbit Degradation, Md Zahidur Rahman, Leonid Roytman, Run Jesmin

Publications and Research

This paper apply an statistical technique to correct radiometric data measured by Advanced Very High Resolution Radiometers(AVHRR) onboard the National Oceanic and Atmospheric Administration (NOAA) Polar Orbiting Environmental Satellites(POES). This paper study Normalized Difference Vegetation Index (NDVI) stability in the NOAA/NESDIS Global Vegetation Index (GVI) data for the period 1982-2003. AVHRR weekly data for the five NOAA afternoon satellites NOAA-7, NOAA-9, NOAA-11, NOAA-14, and NOAA-16 are used for the China dataset, for it includes a wide variety or different ecosystems represented globally. GVI has found wide use for studying and monitoring land surface, atmosphere, and recently for analyzing climate and …

Lacuny Serials Roundtable Meeting Minutes, October 2010, Lacuny

Meeting Minutes

No abstract provided.

The Communicator, October 8, 2010, Bronx Community College

The Communicator

The Communicator newspaper published on October 8, 2010.

Senate Executive Committee Minutes October 4, 2010, Bronx Community College Senate Executive Committee

BCC Governance Archives

Minutes for the meeting of the Senate Executive Committee on October 4, 2010.

Mothers In Trouble: Coping With Actual Or Pending Separation From Children Due To Incarceration, Katarzyna Celinska, Jane A. Siegel

Publications and Research

Although female offenders are the fastest growing population in prison today, relatively few studies focus on their unique experiences as mothers. In this study, the authors utilize 74 semistructured interviews with mothers before trial and during incarceration to document coping strategies employed to deal with potential or actual separation from their children. From the study data, seven strategies emerge: being a good mother, mothering from prison, role redefinition, disassociation from prisoner identity, self-transformation, planning and preparation, and self-blame. The findings show that mothers used multiple strategies and tended to employ emotion-focused and adaptive coping techniques. The policy implications are discussed.

Forecasting The New York State Economy With “Terraced” Vars And Coincident Indices, Eric Doviak, Sean P. Macdonald

Publications and Research

This paper introduces “Terraced” Vector Autoregressive (VAR) models, an innovative twist on traditional VAR modeling, which allows the econometrician to simultaneously forecast both exogenous and endogenous variables and the confidence intervals around those forecasts. In an application of our Terraced VAR framework, we have estimated coincident indices of economic activity for the United States, New York State and the six largest metropolitan areas of New York State and incorporated them into Terraced VARs, which forecast the unemployment rate, total non-farm employment, real wages and average hours worked in manufacturing in those regions.

Molecular Signatures Of The Primitive Prostate Stem Cell Niche Reveal Novel Mesenchymal-Epithelial Signaling Pathways, Roy Blum, Rashmi Gupta, Patricia E. Burger, Christopher S. Ontiveros, Sarah N. Salm, Xiaozhong Xiong, Alexander Kamb, Holger Wesche, Lisa Marshall, Gene Cutler, Xiangyun Wang, Jiri Zavadil, David Moscatelli, E. Lynette Wilson

Publications and Research

Background Signals between stem cells and stroma are important in establishing the stem cell niche. However, very little is known about the regulation of any mammalian stem cell niche as pure isolates of stem cells and their adjacent mesenchyme are not readily available. The prostate offers a unique model to study signals between stem cells and their adjacent stroma as in the embryonic prostate stem cell niche, the urogenital sinus mesenchyme is easily separated from the epithelial stem cells. Here we investigate the distinctive molecular signals of these two stem cell compartments in a mammalian system. Methodology/Principal Findings We isolated …

Drug Off-Target Effects Predicted Using Structural Analysis In The Context Of A Metabolic Network Model, Roger L. Chang, Lei Xie, Philip E. Bourne, Bernhard O. Palsson

Publications and Research

Recent advances in structural bioinformatics have enabled the prediction of protein-drug off-targets based on their ligand binding sites. Concurrent developments in systems biology allow for prediction of the functional effects of system perturbations using large-scale network models. Integration of these two capabilities provides a framework for evaluating metabolic drug response phenotypes in silico. This combined approach was applied to investigate the hypertensive side effect of the cholesteryl ester transfer protein inhibitor torcetrapib in the context of human renal function. A metabolic kidney model was generated in which to simulate drug treatment. Causal drug off-targets were predicted that have previously been …

Alternation Rate In Perceptual Bistability Is Maximal At And Symmetric Around Equi-Dominance, Rubén Moreno-Bote, Asya Shpiro, John Rinzel, Nava Rubin

Publications and Research

When an ambiguous stimulus is viewed for a prolonged time, perception alternates between the different possible interpretations of the stimulus. The alternations seem haphazard, but closer inspection of their dynamics reveals systematic properties in many bistable phenomena. Parametric manipulations result in gradual changes in the fraction of time a given interpretation dominates perception, often over the entire possible range of zero to one. The mean dominance durations of the competing interpretations can also vary over wide ranges (from less than a second to dozens of seconds or more), but finding systematic relations in how they vary has proven difficult. Following …

Management Of Online Tutorials: A Model For A Step-By-Step Approach, Kanu A. Nagra, Dorothea J. Coiffe

Publications and Research

Online tutorials have great potential to reach a large population and to accommodate multiple learning styles anytime and anywhere. This paper describes the management of online tutorials and related concepts in detail. The review of literature method is used to study the variables. The variables under study include the mission, objectives, funding, manpower, in-house creation, outsourcing, incorporation in curriculum, content, type, technology, metadata, discovery services, script design, standards, assessment, professional training, marketing techniques and future goals for creation and management of online tutorials in libraries. A practical model based on literature study and the authors' experience with online tutorials is …

Enumeration Refactoring: A Tool For Automatically Converting Java Constants To Enumerated Types, Raffi Khatchadourian, Benjamin Muskalla

Publications and Research

Java 5 introduces several new features that significantly improve older Java technology. We consider the new enum construct, which provides language support for enumerated types. Before Java 5, programmers needed to employ various patterns to compensate for the absence of enumerated types in Java. Unfortunately, these compensation patterns lack several highly desirable properties of the enum construct, notably type-safety. We demonstrate an automated refactoring tool called Convert Constants to Enum for transforming legacy Java code to use the new enumeration construct. An interprocedural type inferencing algorithm that tracks the flow of enumerated values drives the approach, and the tool is …

The Cinema Of Control: On Diabetic Excess And Illness In Film, Kevin L. Ferguson

Publications and Research

While not rare, films that do represent diabetes must work around the disease’s banal invisibility,and images of diabetics in film are thus especially susceptible to metaphor and exaggeration.This essay is the first to outline a diabetic filmography, discussing medical and cinematic strategies for visualizing the disease as well as how the illness informs family plots and heroic characters in horror films. Doing so, it participates in a larger discussion of the manner in which film images of ill or disabled groups sustain notions of “normalcy” by both representing and denying otherness.

Electronic Document Delivery: A Survey Of The Landscape And Horizon, Nathan Hosburgh, Karen Okamoto

Publications and Research

The authors examine, based on a survey of users, the electronic document delivery methods currently in place as well as changes in the recent past and future developments. Interlibrary loan and document delivery staff were surveyed from institutions across the United States in order to ascertain what document delivery mechanisms are currently in place, how they are being used, and why. Findings from this study should lead to an increased awareness of electronic delivery options in libraries across the country and elucidate the dynamics involved at individual sites. This, in turn, will assist librarians in making decisions, based not only …

Selective Targeting Of Neuroblastoma Tumour-Initiating Cells By Compounds Identified In Stem Cell-Based Small Molecule Screens, Kristen M. Smith, Alessandro Datti, Mayumi Fujitani, Natalie Grinshtein, Libo Zhang, Olena Morozova, Kim M. Blakely, Susan A. Rotenberg, Loen M. Hansford, Freda D. Miller, Herman Yeger, Meredith S. Irwin, Jason Moffat, Marco A. Marra, Sylvain Baruchel, Jeffrey L. Wrana, David R. Kaplan

Publications and Research

Neuroblastoma (NB) is the most deadly extra-cranial solid tumour in children necessitating an urgent need for effective and less toxic treatments. One reason for the lack of efficacious treatments may be the inability of existing drugs to target the tumour-initiating or cancer stem cell population responsible for sustaining tumour growth, metastases and relapse. Here, we describe a strategy to identify compounds that selectively target patient-derived cancer stem cell-like tumour-initiating cells (TICs) while sparing normal paediatric stem cells (skin-derived precursors, SKPs) and characterize two therapeutic candidates. DECA-14 and rapamycin were identified as NB TIC-selective agents. Both compounds induced TIC death at …

Scattering Amplitudes From Unitarity-Based Reduction Algorithm At The Integrand-Level, P. Mastrolia, Giovanni Ossola, T. Reiter, F. Tramontano

Publications and Research

Samurai is a tool for the automated numerical evaluation of one-loop corrections to any scattering amplitudes within the dimensional-regularization scheme. It is based on the decomposition of the integrand according to the OPP-approach, extended to accommodate an implementation of the generalized d-dimensional unitarity-cuts technique, and uses a polynomial interpolation exploiting the Discrete Fourier Transform. samurai can process integrands written either as numerator of Feynman diagrams or as product of tree-level amplitudes. We discuss some applications, among which the 6- and 8-photon scattering in QED, and the 6-quark scattering in QCD. samurai has been implemented as a Fortran90 library, publicly available, …

Ageing, The Urban-Rural Gap And Disability Trends: 19 Years Of Experience In China - 1987 To 2006, Xiaoxia Peng, Shige Song, Sheena Sullivan, Jingjun Qiu, Wei Wang

Publications and Research

Background: As the age of a population increases, so too does the rate of disability. In addition, disability is likely to be more common in rural compared with urban areas. The present study aimed to examine the influence of rapid population changes in terms of age and rural/urban residence on the prevalence of disability.

Methods: Data from the 1987 and 2006 China Sampling Surveys on Disability were used to estimate the impacts of rapid ageing and the widening urban-rural gap on the prevalence of disability. Stratum specific rates of disability were estimated by 5-year age-group and type of residence. The …

Delayed Onset Of A Daytime Nap Facilitates Retention Of Declarative Memory, Sara E. Alger, Hiuyan Lau, William Fishbein

Publications and Research

Background Learning followed by a period of sleep, even as little as a nap, promotes memory consolidation. It is now generally recognized that sleep facilitates the stabilization of information acquired prior to sleep. However, the temporal nature of the effect of sleep on retention of declarative memory is yet to be understood. We examined the impact of a delayed nap onset on the recognition of neutral pictorial stimuli with an added spatial component. Methodology/Principal Findings Participants completed an initial study session involving 150 neutral pictures of people, places, and objects. Immediately following the picture presentation, participants were asked to make …

Variability In Avian Eggshell Colour: A Comparative Study Of Museum Eggshells, Phillip Cassey, Steven J. Portugal, Golo Maurer, John G. Ewen, Rebecca L. Boulton, Mark E. Hauber, Tim M. Blackburn

Publications and Research

Background The exceptional diversity of coloration found in avian eggshells has long fascinated biologists and inspired a broad range of adaptive hypotheses to explain its evolution. Three main impediments to understanding the variability of eggshell appearance are: (1) the reliable quantification of the variation in eggshell colours; (2) its perception by birds themselves, and (3) its relation to avian phylogeny. Here we use an extensive museum collection to address these problems directly, and to test how diversity in eggshell coloration is distributed among different phylogenetic levels of the class Aves. Methodology and Results Spectrophotometric data on eggshell coloration were collected …

Drug Offenders’ Perceptions Of Motivation: The Role Of Motivation In Rehabilitation And Reintegration, Lior Gideon

Publications and Research

This article presents a qualitative analysis of participants’ perceptions of the importance of motivation in the detoxification and rehabilitation process. As part of an outcome evaluation of recovering drug addicts who participated in a prison-based therapeutic community, 39 participants (a nonrandomized subsample) are interviewed regarding their rehabilitation and reintegration experiences. Although many studies show that participation in prison-based drug treatment programs reduces the likelihood of recidivism, clients in this study suggest that other factors might be equally important, and in particular clients’ own motivation to change their lives. This study raises some questions about the true ability of drug treatment …