Digital Commons Network^™

The Sonic Hedgehog Effector Smoothened Modulates Cholinergic Interneuron Activity, Physiology, And Striatum-Dependent Behaviors, Santiago Uribe-Cano

Dissertations, Theses, and Capstone Projects

The striatum is a central node in action selection and associative learning, integrating cortical, thalamic, and neuromodulatory input. Among its principal modulators, dopamine (DA) and acetylcholine (ACh) are known for their temporally coordinated yet mechanistically distinct influences on striatal output. However, the upstream signals that regulate their dynamic interplay, particularly within cholinergic interneurons (CINs)—the primary source of striatal ACh—remain incompletely characterized. This dissertation investigates the role of Smoothened (Smo), a G protein-coupled receptor (GPCR) effector of Sonic Hedgehog (Shh) signaling, in modulating ACh signaling dynamics in the striatum.

Building on evidence that midbrain DA neurons co-release Shh and that CINs …

Choreographies Of Care: Disability And Relationality In Performance, Kiera Bono

Dissertations, Theses, and Capstone Projects

My dissertation explores enactments of what I am calling “choreographies of care” in interdisciplinary performance practices in the 21^st century. Working across disability studies, race and ethnicity studies, queer theory, and performance studies, I investigate the ways in which chronically ill and disabled artists have generated multisensorial movement, sound, and performance works that resist normative understandings of time, space, bodies, and interactions between bodies. Focusing mostly on performances and events that I have attended in New York City or virtually over the past decade, my project engages directly with disability arts communities in which I have been deeply embedded …

Teaching And Technology: "You Can't Just Do The Same Thing Online", Sakina Laksimi

Dissertations, Theses, and Capstone Projects

This dissertation examines how faculty at the City University of New York navigated the abrupt transition to online teaching during the COVID-19 pandemic, revealing how pedagogy is shaped by technological, institutional, and social conditions. Drawing on twenty-two interviews with twelve faculty across eight disciplines, I use a grounded theory approach to analyze how instructors adapted courses, reimagined assessment, and sustained connection with students amid crisis. Three overlapping pedagogical orientations emerged: improvisational, relational, and design-based teaching. These approaches highlight how faculty balanced responsiveness, care, and intentional course design in environments mediated by digital platforms and marked by inequity. The study situates …

Towards Automated Evolution Of Imperative Deep Learning Programs, Tatiana Castro-Vélez

Dissertations, Theses, and Capstone Projects

Software engineering (SE) is increasingly intersecting with data-centric domains such as machine learning (ML) and deep learning (DL). Similar to bugs in traditional software systems, defects can emerge in ML and DL systems. ML, including DL, systems are now widespread and rely on dynamic models defined by input data. Developers face the challenge of building dependable systems while addressing the demand for scalable software.

Efficiency is essential to support responsiveness with respect to ever-growing datasets. Traditional DL frameworks achieve scalability through deferred execution, enabling symbolic, graph-based deep neural network (DNN) computation. While efficient, this approach is error-prone, cumbersome, and difficult …

The Effect Of Tbi On Working Memory And Anxiety In Rats, Mariola Sobolewska

Dissertations, Theses, and Capstone Projects

Traumatic Brain Injury (TBI) is a significant public health concern, often leading to cognitive and emotional impairments. This study examined the effects of TBI on working memory and anxiety-like behavior in young male Sprague-Dawley rats using the Radial Arm Maze (RAM) and Elevated Plus Maze (EPM), which are behavioral assessments. The RAM tests spatial working memory by evaluating the animal’s ability to remember and efficiently navigate multiple arms to retrieve rewards. The EPM assesses anxiety-like behavior based on the animal’s preference for open versus closed arms. The study utilized young male Sprague-Dawley rats, a well-established rodent model known for its …

Repurposing Atractylenolide Iii, A Natural Anti-Inflammatory Compound, For Alzheimer’S Disease, Angela M. Steele

Dissertations, Theses, and Capstone Projects

Alzheimer’s disease (AD) is a debilitating neurological condition ranked as the fifth leading cause of death in adults over the age of 65. Despite the severity, 98% of drugs have failed as treatments for AD. Current novel drug development approaches have been unable to produce a disease-modifying treatment as they often have a one-target approach, not accounting for the complex nature of the disease. One of the hallmarks of the disease, inflammation, may provide a better target for treatment because it interacts with multiple facets of the disease. Drug repurposing to identify compounds that mitigate inflammation in AD could provide …

Text-Based Propaganda Detection, Vivek Sharma

Dissertations, Theses, and Capstone Projects

In the digital age, the swift consumption of news and the widespread dissemination of propaganda significantly threaten democratic principles and informed decision-making. News organizations, often aligned politically, tailor their content to appeal to specific audiences, thereby perpetuating biases. Despite advancements in detecting propaganda through various computational techniques, including Large Language Models(LLM) and BERT-based approaches, significant challenges persist concerning data availability and the effectiveness of detection tools. This thesis explores the landscape of text-based propaganda and reviews related research in textual analysis. It introduces a novel method for collecting a social-media based dataset, which includes analysis of journalists' tweets to discern …

The Architecture Of Exclusion: Disability, Race, And The History Of New York City’S 600 Schools, Francine Almash

Dissertations, Theses, and Capstone Projects

This dissertation investigates the largely erased history of New York City’s 600 schools—segregated public schools created to house students labeled as emotionally disturbed or socially maladjusted. These institutions, operating throughout the mid-20th century, disproportionately served Black and Puerto Rican youth, many of whom were placed in these schools under vague behavioral criteria and with little to no pathway for return to general education settings.

Combining archival research, longitudinal policy analysis, historical media review, and critical race and disability studies frameworks—including DisCrit (Disability Critical Race Theory)—this project situates the 600 schools at the intersection of institutional racism and ableism. It argues …

Investigating The Role Of Early Growth Response 1 (Egr1) Gene In Riluzole-Induced Apoptosis In Osteosarcoma, Syeda Maryam Azeem

Dissertations, Theses, and Capstone Projects

Osteosarcoma is a rare but aggressive bone malignancy most commonly affecting adolescents and young adults (AYA). With 5-year survival rate stagnating over the last four decades despite the advancements in multi-modal therapy, drug repurposing offers a rapid path to new osteosarcoma treatments. Recent studies suggest that Riluzole, a drug approved for amyotrophic lateral sclerosis (ALS), may be repurposed for osteosarcoma treatment due to its ability to slow tumor progression and induce apoptosis. Previously, we have shown that Riluzole increases reactive oxygen species (ROS), activating c-Abl, which phosphorylates YAP in the nucleus. YAP then forms a complex with p73 to enhance …

Online Resources For Oral Communication Courses, Sean P. Palmer

Dissertations, Theses, and Capstone Projects

Online resources focusing on oral communication skills are lacking, even as online education itself expands. While I was aware of this lack, I didn’t realize its severity until LaGuardia Community College went fully remote during the 2020 global pandemic, and I was looking for online tutoring aids for oral communication. Furthermore, the information presented online is frequently unsuitable for the purposes of online pedagogy due to its specialized and jargony mode of presentation. Also, many existing assignments involving oral communication assume public speaking as the default model, despite the growing importance of emergent digital modes of oral performance, like podcasting …

Between The Buffer And The Black Box: Ed(1), Invisible Text, And Delegation In Word Processing, Kai Prenger

Dissertations, Theses, and Capstone Projects

This thesis provides a media archaeological and theoretical examination of ed(1), the Unix line editor developed by Ken Thompson at Bell Labs in 1969, arguing that its approach to "invisible text" processing established lasting patterns of human-computer collaboration that persist in contemporary digital systems. Through historical research, technical analysis, and critical interpretation, this study demonstrates how ed(1) embodied a particular epistemology of text processing that appears alien in a contemporary context, but proves insightful in the age of generative text creation.

ed(1) emerged from the unique convergence of Bell Labs' collaborative research culture, severe hardware constraints of early Unix systems, …

From Stories To Strategy: Oral Histories As Qualitative Evidence For Neighborhood Planning, Randip K. Parhar

Dissertations, Theses, and Capstone Projects

Developments in neighborhood planning have sought more grounded and community- engaged approaches to space and service design. This capstone project examines how oral history recordings can serve as a data source for neighborhood planning. It asks “How can computational methods of analysis be applied to oral history recordings to provide a source of information for neighborhood planning?” using Jamaica, Queens, as a testbed. Using R as a computational tool, the project applies foundational text mining techniques, such as term frequency analysis, n-gram analysis, and topic modeling, to explore patterns and themes within the recorded narratives. These methods can provide a …

Socioeconomic Stasis And Racial Immobility In The United States: How Does American Political Polarization Contribute To African American Poverty?, Carmel Agnant

Dissertations, Theses, and Capstone Projects

African Americans in the United States presently exist in a poverty-stasis, a perpetual social and economic underclass positioning despite a constantly evolving American economy, society, and bodies of legislations due to political polarization. This follows a lengthy history of racial immobility (preventing a racial group from economic mobility) and stagnation since America’s era of sectional polarization over slavery. African Americans lack access to build wealth and have always struggled with societal exclusion. Legislation created and enacted that would support them politically, legally, socially, and/or economically are consistently met with legislative gridlock or countervailing measures to reverse and nullify advancements in …

Re-Envisioning Digital Agency: From Representationalism To Interpretant-Driven Epistemology, Michael C. Lee

Dissertations, Theses, and Capstone Projects

This thesis examines the epistemological and ethical foundations of digital technologies, particularly code and algorithmic systems, by considering their entanglement with representationalism. Arguing that code now functions as a dominant social agent and epistemic subject, through the concept of the Code’s-eye view, I explore how automated datafication reduces human experience to quantifiable inputs, reinforcing epistemic closure and social fragmentation. Drawing on pragmatist philosophy, including Peirce’s semiotics, Dewey’s democratic ethics, and Rorty’s conversational inquiry, I propose an interpretant-driven epistemology grounded in communal inquiry and interpretive openness. This alternative framework resists the binary logic of algorithmic rationality by emphasizing conflict and the …

The Role Of Parent Psychiatric Symptoms In The Intergenerational Continuity Of Child Neglect: A Prospective Examination, Cody D. Stitzel

Dissertations, Theses, and Capstone Projects

Parental history of childhood neglect is a risk factor for offspring neglect. When a parent and their offspring both experience neglect in childhood, the phenomenon is referred to as the intergenerational continuity of child neglect. Understanding how child neglect is continued from one generation to the next is essential for creating effective interventions and prevention strategies that may help break the cycle. Since links between childhood neglect and heightened risk for various psychiatric symptoms have consistently been identified in research, as well as links between various psychiatric symptoms and heightened risk for child neglect, it may be that parents’ psychiatric …

Britten’S Violin Concerto And His Early Period—Score Analysis And Pacifist Narrative, Magdalena Filipczak

Dissertations, Theses, and Capstone Projects

This dissertation presents a comprehensive study of Benjamin Britten’s Violin Concerto, Op. 15, using the work as a lens through which to examine the composer’s early period. Rather than treating the concerto as a purely technical or stylistic artifact, the study situates it within the broader context of Britten’s formative years, his early artistic circles, the political tensions of the 1930s, and his evolving pacifist stance.

The final third of the dissertation offers a detailed formal and interpretative analysis of the full orchestral score, tracing an expressive arc across the entire work by identifying an idée fixe motif and following …

Structural Characterization Of A Tarantula Toxin And Its Interactions With Lipid Bilayers And Voltage-Gated Sodium Channels, Krishnakoli Adhikary

Dissertations, Theses, and Capstone Projects

Voltage-gated ion channels are membrane protein complexes. They allow the selective flow of their respective ions down an electrochemical gradient through a central ion conduction pore surrounded by four voltage-sensing domains (VSDs). Various neurological and cardiovascular diseases are caused by mutations in voltage-gated ion channels (VGICs). One of the biggest challenges today is addiction to opioid medication. Coming up with non-opioid drug leads can be a real blessing for society. This is where voltage-gated sodium channel research comes in. Na_v1.7, Na_v1.8, and Na_v1.9 are responsible for pain sensations. Loss or gain of function in …

Reinforcement Learning Based Resource Management In Edge Systems, Motahare Mounesan

Dissertations, Theses, and Capstone Projects

Modern end-user applications that are highly compute- and data-intensive, while being extremely latency- and accuracy-sensitive, are increasingly reliant on distributed computing. This paradigm spans a range of architectures, from cloud computing to in-device processing. Cloud computing, though scalable, often incurs high latency and cost, constraints that are particularly problematic for time-sensitive applications. In contrast, in-device computing on end or IoT devices is limited by resource constraints, making it inadequate for many complex workloads. Edge computing presents a compelling alternative by bringing computation closer to data sources, thereby reducing end-to-end latency and improving responsiveness. However, the inherent decentralized and dynamic nature …

Tradition, Individuality, And Innovation In Western Classical Music Performance: A Quantitative Analysis Of Bach’S Fourth Cello Suite Prelude, Clare Monfredo

Dissertations, Theses, and Capstone Projects

Why do we seek out new performances of a commonly performed piece of music? An essential tradition of Western classical music (WCM) is the performance of canonical works by composers, an activity that requires the interpretation and execution of written scores by individual performers. In this practice, performers are not only expected to determine the composer’s “intentions,” but also somehow (paradoxically) share these in a “unique” performance interpretation. In musical education, performers are trained by teachers to create these “unique” interpretations by learning how to intuit composers’ intentions in a system that passes down interpretative traditions through master-apprentice one-on-one lessons. …

Improving The Assessment Of Functional Ability In Older Adults, Aneela Rahman

Dissertations, Theses, and Capstone Projects

Deficits in instrumental activities of daily living (IADL) are a hallmark of dementia, and the unprecedented aging of the population strongly motivates early identification of older adults at-risk for functional decline. In 2015, the White House Conference on Aging emphasized the need to improve detection of diminished capacity across important areas of functioning. To date, there is very limited research on early IADL changes in cognitively unimpaired (CU) individuals and those with subjective cognitive decline (SCD) and mild cognitive impairment (MCI), who may be in early preclinical dementia stages. Additionally, little is known about how changes in functional brain networks …

Compensation, Horizontal Diffusion, And Bottom-Up Pathways: State Climate Policies In The United States And Australia, Ian Bailey, Roger Karapin

Publications and Research

Recent years have seen growing interest in subnational governments as arenas of climate governance, but limited systematic research exists on the extent, conditions, or pathways through which subnational climate policies can influence, or compensate for deficits in, national policies. This article addresses this gap by examining options for states to influence climate policy in the United States and Australia, two countries where federal governments have made limited progress in developing national climate policies. As an analytical framework, it conceives a typology of state government approaches to climate policy that distinguishes among compensating, horizontal diffusion, and bottom-up pathways. It then uses …

Geol 64: Planetary Geology - Syllabus, Dara Laczniak

Open Educational Resources

This Open Educational Resources (OER) syllabus is for an introductory planetary geology course that utilizes results from space missions to expose students to the surface features, composition, geological activity, and probable history of the planets, moons, asteroids, and comets of the solar system. It also places space exploration into the context of larger societal issues such as global warming and natural resource availability and addresses topics such as the ethics of space exploration and hazards of space travel. This OER syllabus aims to foster student-centered learning, critical thinking, data analysis and communication skills, and creativity. Assigned readings are compiled into …

Clss12100- The Greek And Latin Roots Of English - Syllabus, Camilo Andrés Bonilla Carvajal

Open Educational Resources

No abstract provided.

Asia In World Politics Syllabus, Muhammad S. Kabir

Open Educational Resources

The continent of Asia is one of the fastest-growing regions in the world. The continent also hosts some of the oldest interstate conflicts, ranging from disputed borders to nuclear proliferation. This course examines the sources of insecurity and conflict in Asia. The course focuses on several interstate and regional conflicts: the Kashmir Conflict between India and Pakistan, nuclear proliferation on the Korean Peninsula, the South China dispute, and the China-Taiwan relations. Although some of these disputes remain latent as of now, they have the potential to turn into outright regional wars with catastrophic consequences for the region and potentially for …

The State Of The Unions 2025: A Profile Of Organized Labor In New York City, New York State, And The United States, Ruth Milkman, Joseph Van Der Naald

Publications and Research

Organized labor has taken center stage in the 2020s, with workers leading successful organizing drives at Amazon, Starbucks, Apple, and across a range of industries from health care to higher education. Public approval of unions has reached its highest level in decades, and a new generation of workers is stepping forward as leaders in the movement. The State of the Unions 2025 provides the most comprehensive profile of organized labor in New York City, New York State, and the United States, highlighting where unions are growing, who is leading the charge, and how labor is shaping the future of work …

Generative Ai In The Classroom: Best Practices, A Cetll Guide, The Center For Excellence In Teaching, Learning, & Leadership, S E. Hackney, Brandon K. Jeffries Mr., Emily Drabinski, Joshua Rogers, Holly Weisberg, Yael Neumann, Ashlyn Cavitt, Claudia Brumbaugh, Lindsey Albracht, Robin Naughton, Annalee Roustio, Amy Wan, Soniya Munshi, Jean Kelly

Open Educational Resources

In 2024-2025, in collaboration with Amy Wan, Professor of English and Special Assistant to the Provost for Writing, CETLL hosted a Generative AI in the Classroom Faculty Fellowship, through which an interdisciplinary cohort of thirteen faculty members were supported to critically engage the different concerns and opportunities that generative AI presents for our work as educators.

From our discussions with the Faculty Fellows and other resources, we have developed Generative AI in the Classroom: Best Practices, a CETLL Guide. This guide includes step-by-step guidance about how to engage with questions of generative AI in your classrooms, sample syllabus statements, …

Zero/Low Textbook Cost Syllabus For [39335 Eng 2100 - Htrf Writing I], Ju Ly Ban

Open Educational Resources

This class is a warm-up for the many writing assignments you will encounter, no matter your major. We will read, write, and talk through texts in different genres, learning how to (1) understand what a writing task is asking for (2) build clear arguments (3) find strong evidence and (4) manage time and writing anxiety. These skills will help you revisit, rethink, and expand your own resources.

You are the writer. (Yes, even if you use ChatGPT. We will talk about how to use it well, too.) And you already have your resources. Let’s begin in an imaginary living room—the …

Geol 12 Natural Disasters Syllabus, Anestoria Shalkowski

Open Educational Resources

Hazards are events which have the capabilities to damage property and or life. Understanding natural hazards and how these can become disasters are important in reducing the impacts of such events. This syllabus provides a description of the material to be examined and the expected student outcomes upon completion of the course.

Disentangling The Effect Of Criminal Legal System Involvement On Mental Health In The United States, Pui Ying Chan

Dissertations and Theses

BACKGROUND: Interactions with the criminal legal system (CLS), such as through arrest or incarceration, are relatively common in the United States (US) and are increasingly recognized as social risk factors for poor mental health. Previous studies have reported a positive association between CLS involvement and poor mental health, with some theoretical frameworks, including the ecosocial theory and the stress process paradigm, supporting a plausible causal relationship. However, prior research has significant limitations in providing casual evidence given possible reverse causation in cross-sectional studies and insufficient consideration for the dynamics between CLS exposures, mental health status, and related confounders over time …

Mca 10100 Oer/Ztc Syllabus, Daniel Gilmore

Open Educational Resources

This is a syllabus for the MCA 10100 Introduction to Media Studies course taught at City College in the Media & Communication Arts department. It is an OER & ZTC compliant syllabus.