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Heterometallic Titanium–Gold Complexes Inhibit Renal Cancer Cells In Vitro And In Vivo, Jacob Fernandez-Gallardo, Benelita T. Elie, Tanmoy Sadhukha, Swayam Prabha, Mercedes Sanau, Susan A. Rotenberg, Joe W. Ramos, Maria Contel

Publications and Research

Following recent work on heterometallic titanocene–gold complexes as potential chemotherapeutics for renal cancer, we report here on the synthesis, characterization and stability studies of new titanocene complexes containing a methyl group and a carboxylate ligand (mba ¼ S–C6H4–COO) bound to gold(I)-phosphane fragments through a thiolate group [(h-C5H5)2TiMe(m-mba)Au(PR3)]. The compounds are more stable in physiological media than those previously reported and are highly cytotoxic against human cancer renal cell lines. We describe here preliminary mechanistic data involving studies on the interaction of selected compounds with plasmid (pBR322) DNA used as a model nucleic acid, and with selected protein kinases from a …

Human Anatomy And Physiology Preparatory Course (1st Edition), Carlos Liachovitzky

Open Educational Resources

The overall purpose of this preparatory course textbook is to help students familiarize with some terms and some basic concepts they will find later in the Human Anatomy and Physiology I course.

The organization and functioning of the human organism generally is discussed in terms of different levels of increasing complexity, from the smallest building blocks to the entire body. This Anatomy and Physiology preparatory course covers the foundations on the chemical level, and a basic introduction to cellular level, organ level, and organ system levels. There is also an introduction to homeostasis at the beginning.

Las Casas Remembered:The 500th Anniversary Of The Struggle For The Human Rights Of The Native Peoples Of America, David M. Traboulay

Publications and Research

At first a part of the colonial system as an encomendero, he later dedicated his life to the struggle for justice and human rights of the indigenous peoples of America. At the grand debate of 1551 between Dr. Sepulveda and Las Casas, Las Casas presented a very modern view of human rights that is one of the useful models of human rights for the contemporary world.

Acute Cocaine Differentially Induces Pka Phosphorylation Substrates In Male And Female Rats, Wei-Lun Sun, Luyi Zhou, Arbi Nazarian, Vanya Quinones-Jenab, Shirzad Jenab

Publications and Research

Background: Sex differences in intracellular dopamine pathways may contribute to the known sex differences in psychomotor responses to cocaine and differential development of dependence. This study aimed to determine whether there are sex differences in the activation of the extracellular signal-regulated kinases (ERK1/2, or p44/p42 MAPK) and PKA phosphorylation-dependent substrates in the nucleus accumbens (NAcc) of male and female rats at baseline or after acute cocaine administration.

Methods: 60-day-old male and female Fischer rats were injected with saline or cocaine (30 mg/kg) and sacrificed 5, 15, 30, 45 or 90 minutes later. Total locomotor activity, Stereotypic, rearing, and ambulatory behaviors …

The Use Of Psychological Defense Mechanisms – By Librarians And The Public – In Response To Traditional And Binary Librarian Stereotypes, Beth Posner

Publications and Research

Images of librarians in popular culture include the traditional stereotype - of a mousy spinster who cares more for protecting books than for helping people - as well as several contrasting or binary images - such as librarians who are wild by night (although quiet by day), know-it-alls (rather than know-nothings), or high-tech (instead of old-fashioned.) In response to the anxiety provoked by the more pernicious aspects of these images, both librarians and the public may employ a variety of common unconscious defense mechanisms. This chapter examines some of those used by the public - including stereotyping, and splitting or …

Specters Of Kurdish Nationalism: Governmentality And Counterinsurgent Translation In Turkey, Nicholas S. Glastonbury

Publications and Research

This essay examines translations of the Kurdish epic poem Mem û Zîn into Turkish, tracing the logics behind these state-sponsored translations and examining how acts of translation are also efforts to regulate, translate, and erase Kurdish subjectivities. I argue that the state instrumentalizes Mem û Zîn’s potent nationalist currency in order to disarm present and future claims of Kurdish national autonomy. Using translation as a counterinsurgent governmental tool, the state attempts to domesticate Kurdish nationalist discourses even as it reproduces them, thereby transforming Kurdish nationalism into a specter of itself. Attending to this specter, however, allows us to see how …

A Principle Of Economy Predicts The Functional Architecture Of Grid Cells, Xue-Xin Wei, Jason Prentice, Vijay Balasubramanian

Publications and Research

Grid cells in the brain respond when an animal occupies a periodic lattice of ‘grid fields’ during navigation. Grids are organized in modules with different periodicity. We propose that the grid system implements a hierarchical code for space that economizes the number of neurons required to encode location with a given resolution across a range equal to the largest period. This theory predicts that (i) grid fields should lie on a triangular lattice, (ii) grid scales should follow a geometric progression, (iii) the ratio between adjacent grid scales should be √e for idealized neurons, and lie between 1.4 and 1.7 …

The Synthesis And Characterization Of Dual-Modified Carboxymethylcellulose For Bioadhesive Applications, Fabrice Bernard

Dissertations and Theses

Reparative medical techniques, in conjunction with existing and emerging tissue adherents and sealants, offer practicing physicians a wide variety of tools to improve the functionality, performance, and safety of surgical interventions. Carboxymethylcellulose (CMC) is a plant-derived polymer that is cytocompatible, biocompatible, biodegradable, and inexpensive. The need for a non-toxic but strongly adherent material motivated the development of an injectable bioadhesive system containing CMC modified with functional methacrylate and aldehyde groups that could potentially be used as an annulus fibrosus sealant or as a supplement to existing wound closure materials. After modification, the polymer was characterized via NMR spectroscopy, Schiff’s base …

Santa Cruz, Paden Grey

Dissertations and Theses

No abstract provided.

Sing Me A Song Of Sorrow: Analzying The Internal Dynamics Of Howl And Its Place As A Modern Epic, Anthony Hosey

Dissertations and Theses

No abstract provided.

The Hunger For Justice, Donald Rielly

Dissertations and Theses

No abstract provided.

Why Are Grimms' Fairy Tales So Mysteriously Enchanting?, Ana Neophytou

Dissertations and Theses

No abstract provided.

Can Gender-Stereotyped Depictions Of Occupations In Primary School Textbooks Help Shape Students' Career Choice In The Dominican Republic?, Hurtado Pérez Nohemí

Dissertations and Theses

No abstract provided.

Effects Of Acetyl Salicyclic Acid On Drosophila Models Of Cancer-Inflammation, Roma Rajwani

Dissertations and Theses

Chronic inflammation is a fundamental condition underlying many human disease pathologies including diabetes, cancer, and neurodegeneration. Indeed, one of the most commonly-used anti-inflammatory drugs, aspirin, has been shown to be effective in the treatment of many cancers. To understand the mechanistic linkages between inflammation and cancer, we used Drosophila models in which hyperactive immune signaling causes overproliferation of the hematopoietic system leading to the production of inflammatory blood tumors. In mutant animals, hematopoietic cells divide uncontrollably and exhibit pre-mature differentiation giving rise to large sticky cells. Some mutant cells infiltrate and adhere to cells of the fat body. The fat …

Effects Of Temperature Stress On Coral Fluorescence And Reflectance, Andrea Gomez

Dissertations and Theses

Around the world, climate change, land-based pollution and fishing impacts are recognized as principal threats to coral reef ecosystems. Sea surface temperatures, in particular, are expected to change dramatically over the next decades and result in high coral mortality in some regions. Through controlled experiments, I examined changes in coral fluorescence and reflectance in response to water temperature alterations to assess the potential of employing these signatures as a diagnostic tool to measure coral health. At the NOAA Coral Culture and Collaborative Research Facility, I conducted controlled laboratory-based heat stress experiments on three Caribbean species of coral: Acropora cervicornis, Orbicella …

Development And Maintenance Of Thymic Epithelial Microenvironment, Varan J. Singh

Dissertations and Theses

Thymus is a primary lymphoid organ responsible for proper development and selection Of T-­‐cells. The thymic microenvironment, however, undergoes age related involution, Resulting in a reduction of the repertoire of T-­‐cells that are produced, and a decreased Capacity to respond to new antigen. Even though significant thymic epithelial turnover occurs, it is unclear if postnatal thymic progenitors/stem cell are responsible for the maintenance of the TEC microenvironment. Here we use the K5rtTA:TetO-­‐H2BGFP transgenic model to identify a slow cycling potential stem cells/progenitor population in the postnatal thymus. These cells were isolated, expanded in culture, and successfully differentiated into adipocytes, chondrocytes …

Food Imports As A Hindrance To Food Security And Sustainable Development: The Cases Of Nigeria And Senegal, Dioume Astou

Dissertations and Theses

Despite the growing global acceptance of an individual’s right to adequate food and nutrition, and the state’s obligation to ensure that all its citizens are free from hunger, 805 million or one in nine people around the world today are still chronically malnourished; the majority live in developing countries. African states have had a particular problem with food insecurity. Food security on the continent has worsened since the 1970s and by the end of the century, the population in Africa is

expected to be three times its current level. Hence, food insecurity in Africa will be much more severe than …

The Will To Change: The Role Of Self-Consciousness In The Literature Of Metamorphosis, Michael Giovanniello

Dissertations and Theses

No abstract provided.

The Widespread Skink Mabuya Dorsivittata Reveals Complex Patterns Of Genetic Diversity In South America, Danielle Rivera

Dissertations and Theses

No abstract provided.

Factors Which Prolong Civil Conflict In Africa: The Case Of Angola, Liberia And Sierra Leone, Ntesang Lorraine Molemele

Dissertations and Theses

It has been a long journey for this thesis accomplishment and now finally it is accomplished. First and foremost I thank God for my mother, Seskhutshwe, who has always wanted her children to accomplish through education. It would not have been possible of course without my dad, Judge and my little sister Ikey. My 9 year old daughter, I also thank her for always making sure she did not disturb me whenever I had to concentrate on this project. Above all, I wish to express my gratitude to my exceedingly patient Professor and supervisor, Jacqueline Braveboy. I have probably been …

Protofeminist Women In Bronte’S Jane Eyre And Braddon’S Lady Audley’S Secret, Allison Wong

Dissertations and Theses

No abstract provided.

The Impact Of Forest Successional Status On Community Structure Of Neotropical Cerambycid Beetles, Lin Li

Dissertations and Theses

Due to anthropogenic activities, tropical rain forests face many challenges in sustaining biodiversity and maintaining global climates. This project examines how forest successional status affects community composition of saproxylic cerambycids, which, as early colonists of moribund trees, have an important role in nutrient cycling. In the lowland rain forest of Costa Rica, thirty-nine trees in five plant families (Fabaceae, Lecythidaceae, Malvaceae, Moraceae, and Sapotaceae) were sampled in a mosaic of old growth and secondary forest. They yielded 3545 cerambycid individuals in 49 species. Species richness was almost identical in old growth and secondary forest; but abundance was higher in old-growth. …

Refinement Of Feedforward Projections, Neuronal Density, And Characterization Of Synapsesin Layer 4 Of Ferret Primary Visual Cortex, Violeta Contreras Ramirez

Dissertations and Theses

No abstract provided.

Rural Energy Development: Are Mini-Grids The Solution To East Africa's Energy Crisis, John Remson

Dissertations and Theses

As the population and economies of Sub Saharan Africa continue to grow, the demand for modern energy will correspondingly increase. The current energy policy and limited overall access rate is not prepared for this massive demand increases and presents a major hindrance to country growth potential. This thesis focuses on the countries in East Africa (Kenya, Tanzania, Ethiopia), and compares their current energy policies and renewable energy potential within a historical context of the United States rural electrification of 1930s. It is clear that some progress has been made in plans to address the energy access concerns but there is …

The Long Road: Upstate Republicans And Political Reform In New York State, 1906-1927, Todd Leskanic

Dissertations and Theses

No abstract provided.

The Drosophila Dynamin, Shibire, Contributes To Blood Cell Division And Differentiation, But May Not Be Required For Host Defence Against Parasitic Wasps, Adam D. Hudgins

Dissertations and Theses

No abstract provided.

The Hazardous Effects Of Ship Scrapping And Recycling On Workers' Rights And The Environment, Maytee Gomez Salgueiro

Dissertations and Theses

No abstract provided.

What Grows In Heavy Rain, Lisa Martens

Dissertations and Theses

No abstract provided.

Aina: A Modern-Day History Chant Of A Hawaiian Place, Helen Dano

Dissertations and Theses

No abstract provided.

"Alienation In The Egyptian Novel Under Nasser: A Study Of Naguib Mahfouz’S The Beggar And Son’Allah Ibrahim’S That Smell.", Zeina Sabry

Dissertations and Theses

No abstract provided.