Digital Commons Network^™

Rapid Bactericidal Activity Of An Amphiphilic Polyacrylate Terpolymer System Comprised Of Same-Centered Comonomers With 2-Carbon And 6- Carbon Spacer Arms And An Uncharged Repeat Unit, Kamia Punia, Ashish Punia, Kaushiki Chatterjee, Sumit Mukherjee, Jimmie E. Fata, Probal Banerjee, Krishnaswami Raja, Nan-Loh Yang

Publications and Research

The global health threat of antimicrobial resistance has created a pressing need to develop practical alternatives to conventional antibiotic agents. Peptide mimetic synthetic amphiphilic polymers are known to non-specifically disrupt the bacterial cell surface thus leading to highly hindered bacterial resistance development. We investigated the antibacterial activities of a terpolymer macromolecular architecture with a combination of 6- carbon and 2-carbon spacer arms (distance from polymer backbone to pendent cationic center) interspersed with counits with hydrophobic side groups. A random copolymer with a combination of 6-carbon spacer arm repeat units (60 mol%) and 2-carbon spacer arm (40 mol%) units is moderately …

Race, Education, And Reintegrating Formerly Incarcerated Citizens [Introduction, Chapter 6], Joni Schwartz, John R. Chaney

Publications and Research

Building on the framework of critical race theory (CRT), this book through academic research and analysis engages the voices of formerly incarcerated college students' lived experiences as well as college faculty and administrators' understanding of academia as created spaces for reentry.

Ecologies Of The Passions In Early Modern English Tragedies, Roya Biggie

Dissertations, Theses, and Capstone Projects

Ecologies of the Passions recovers a neglected model for understanding early modern relationality, one that turns the seemingly inward experience of emotion outward toward the environment. Drawing on early modern medical texts, I argue that the period’s dramatists imagine bodies as humorally vulnerable to other bodies, both human and nonhuman, within dynamically affective environments. As such, my project illustrates the intimate configurations of human and nonhuman life in early modern tragedies. Building upon recent work in the emerging fields of ecocriticism and affect theory, I argue that the period’s dramatic literature exposes the porous fluidity of the Galenic body—its embeddedness …

Dehumanization: A Case Study, Regina Varthi

Dissertations, Theses, and Capstone Projects

The capstone “Dehumanization” is divided into three main parts.

The first part contains a brief presentation on the UN family (or UN system), showing its role through its organizational and managerial structures. All data are derived from UN corresponding websites.

The second part, “Homelessness,” focuses on the SDG 11 of the 2030 GA Agenda. In 2014 the United Nations Human Rights Council appointed Leilani Farha Special Rapporteur on adequate housing in order to conduct research on the subject of homelessness as a violation of human rights. In her report, presented at the Human Rights Council in March 2016, Farha claims …

Therapeutic Exploitation Of Metabolic Checkpoints In Cancer Cells, Deven S. Patel

Dissertations, Theses, and Capstone Projects

During the G1 phase of the cell cycle, normal cells respond to growth factors and nutrients prior to entering S-phase to replicate its genome. We previously reported that the growth factor-mediated restriction point is distinguishable from a series of late G1 metabolic checkpoints mediated by essential amino acids (EAAs), the conditionally essential amino acid glutamine (Gln), and mTOR – the mammalian target of rapamycin. Mutations in genes encoding proteins that regulate G1 cell cycle progression are observed in virtually all cancers. We observed that cancer cells with K-Ras mutations bypass the late G1 Gln checkpoint when deprived of Gln and …

Solo Performance: An Extension Of Vocal Pedagogy, Monica J. Harte

Dissertations, Theses, and Capstone Projects

In this study, I examine the significance of the solo performance opportunity in vocal pedagogy at the tertiary level. In order to discover tangible correlations between solo performing and applied lessons, I designed and implemented a case study that focused on fourteen subjects rehearsing, performing, and recording roles in the children’s opera, Mambo. The findings stem from my theoretical analysis of substantive data collected through forty-one interviews and three months of observations. The data collected disclosed that whether the participants advanced within a particular performance practice (such as presentation), or developed a specific vocal technique (such as coloratura), Mambo …

Ludic Conceptualism: Art And Play In The Netherlands, 1959 To 1975, Janna Therese Schoenberger

Dissertations, Theses, and Capstone Projects

This dissertation, the first extended study on art in the Netherlands in the 1960s and ‘70s, investigates the phenomenon of ludic art, taking its lead from Johan Huizinga’s definition of ‘ludic’ in his seminal Homo Ludens (1938). According to Huizinga, the ludic is characterized by masquerade, freedom, and purposelessness, to which I add my own theoretical contribution—absurdity. I argue that the key instantiation of Huizinga’s ideas is found in the utopian project New Babylon (1959­–74) by Constant Nieuwenhuys. In the 1960s, ludic art was deployed as a strategy of social critique that attacked from an oblique angle, sometimes effectively­, but …

From Rochel To Rose And Mendel To Max: First Name Americanization Patterns Among Twentieth-Century Jewish Immigrants To The United States, Jason H. Greenberg

Dissertations, Theses, and Capstone Projects

There has been a dearth of investigation into the distribution of and the alterations among Jewish given names. Whereas Jewish surnames are a popular topic of study, first names receive far less analysis. Because Jewish immigrants to the United States frequently changed their names, this thesis can serve as a guide to genealogists and other scholars seeking to trace the paths of Jewish immigrants from Europe. Data was drawn from about 1500 naturalization records from Brooklyn in order to determine the correspondences between the given names featured on passenger lists and their Americanized counterparts. More than three-quarters of surveyed immigrants …

Dopamine D1 And D3 Receptor Polypharmacology In Cocaine Reward And Cocaine Seeking, Ewa J. Galaj

Dissertations, Theses, and Capstone Projects

Background: In the search for efficacious pharmacotherapies to treat cocaine addiction much attention has been given to agents targeting D1 or D3 receptors because of the involvement of these receptors in cocaine-related behaviors. D1 and D3 receptor partial agonists and antagonists have been shown to reduce cocaine reward, reinstatement of cocaine seeking and conditioned place preference (CPP) in rodents and non-human primates. However, translation of these encouraging results with selective D1 or D3 receptor agents has been limited due to a number of factors including toxicity, poor pharmacokinetic properties and extrapyramidal and sedative side effects.

Purpose: Given the …

Rights And Feelings: Marriage Equality And The Language Of Citizenship In Argentina And The United States, Julie Hollar

Dissertations, Theses, and Capstone Projects

By comparing the struggles for marriage equality in Argentina and the United States, this research elucidates the ways discursive change happens around high-profile policy issues, as well as how that process shapes the playing field for future movements. This work builds on scholarship concerning the construction of target populations, arguing that in contests over meaning, the social construction of the central actors shapes both dynamics and outcomes. It uses content analysis and discourse analysis to compare the constructions of gays and lesbians and the state across cases and to trace their impact on the discursive opportunity structure. It also takes …

Beyond The Obvious: Emerging Contaminants And Biogeochemistry As A Cause And Solution For Nitrogen Pollution, Stephanie L. Devries

Dissertations, Theses, and Capstone Projects

Following a comprehensive review of the occurrence and impacts of antibiotics and related pharmaceutical compounds on the terrestrial N-cycle, three experiments were performed to explore the topic of biogeochemistry as a source or a sink for N-pollution. The first of these experiments addresses the question of whether environmentally relevant concentrations of antibiotics (µg·kg^-1) have a significant effect on denitrification or N₂O production, a question that has not been well addressed in previous studies. Having determined that there is a significant shift, the second study aims to comprehensively follow changes to soil N pools and N_{2 …}

Capturing The Attention Of Caregivers: Variability In Infant Vocalizations, Catharine A. Castelluccio De Diesbach

Dissertations, Theses, and Capstone Projects

The effect of variability in infant vocalizations on potential caregivers’ heart rate variability (HRV), facial expressions, and subjective ratings on emotional reactions and desire to approach the baby was examined in an evolutionary context. Recordings of non-canonical, canonical, fussing, and crying vocalizations were utilized to elicit physiological and self-reported reactions from sixty participants. Breastfeeding mothers, non-mothers at high estradiol point in menstrual cycle, non-mothers at low estradiol point in menstrual cycle, fathers, and non-fathers were included in the study. Participants wore Polar RS800 heart rate monitors, were video recorded for facial expression analysis, and filled out 11 point self-rating forms …

Es-Esa: An Information Retrieval Prototype Using Explicit Semantic Analysis And Elasticsearch, Brian D. Sloan

Dissertations, Theses, and Capstone Projects

Many modern information retrieval systems work by using keyword search to locate documents in an inverted index by matching those documents based on terms in a user’s query. While highly effective for many use-cases, one notable drawback to simple keyword-based searching is that the contextual knowledge surrounding the user’s underlying information need may be lost, particularly if the user’s query terms are ambiguous or have multiple meanings. Research in the field of semantic search aims to make progress towards resolving this. One methodology in particular, explicit semantic analysis, works by modeling a document not only as a set of …

The Value Of Value-Added: Science, Technology, And Policy In Educational Evaluation, Daniel Douglas

Dissertations, Theses, and Capstone Projects

In the first decade of the 21^st century, researchers and policymakers in K-12 education began to focus on evaluating teacher and school performance based on students’ standardized test scores. One evaluative technique, value-added assessment (VAA), has been given particular attention. This research presents a comprehensive study of the theoretical, technical, historical and political dimensions VAA. Theoretically, the assumptions that underlie value-added diverge significantly from the observed operations of the schools and classrooms these models are supposed to evaluate. Technically, even if the theoretical assumptions are accepted, teachers’ actual value-added rankings are shown to be unstable across time periods and …

Tandem 2.0: Image And Text Data Generation Application, Christopher J. Vitale

Dissertations, Theses, and Capstone Projects

First created as part of the Digital Humanities Praxis course in the spring of 2012 at the CUNY Graduate Center, Tandem explores the generation of datasets comprised of text and image data by leveraging Optical Character Recognition (OCR), Natural Language Processing (NLP) and Computer Vision (CV). This project builds upon that earlier work in a new programming framework. While other developers and digital humanities scholars have created similar tools specifically geared toward NLP (e.g. Voyant-Tools), as well as algorithms for image processing and feature extraction on the CV side, Tandem explores the process of developing a more robust and user-friendly …

Dancing Silhouettes: Lotte Reiniger's The Adventures Of Prince Achmed: A Critical Study, Maria N. Rhodes

Dissertations, Theses, and Capstone Projects

Lotte Reiniger’s The Adventures of Prince Achmed has been relegated to a curiosity in film history textbooks for some time. Known as the first surviving feature length animated film, it is talked about but rarely seen. However, it is more than just a point in a film history timeline. The film is a beautiful piece of art that engages with the time period in which it was made in a critical and political way. The subject matter, silhouettes as animation, the political atmosphere of Weimar Republic Era Berlin and the role of the spectator are all explored in this thesis …

Zooarchaeological And Palaeoenvironmental Reconstruction Of Newly Excavated Middle Pleistocene Deposits From Elandsfontein, South Africa, Frances L. Forrest

Dissertations, Theses, and Capstone Projects

Increased consumption of animal tissue is arguably one of the most important adaptive transitions in early hominin behavior. A dietary shift toward regular tool-assisted meat consumption and increased competition with the carnivore paleoguild likely helped shape many important hominin adaptations such as foraging patterns, habitat preferences, and social behaviors. Yet, the ecological and behavioral implications for increased hominin carnivory remain poorly understood. This dissertation examines the zooarchaeological and paleoenvironmental history of an important Acheulean hominin locality, Elandsfontein, South Africa (ca. 1.0 – 0.6 Ma). The goal is to begin addressing under-investigated aspects of Acheulean hominin behavioral ecology and place Acheulean …

Removal Of Organic Micro-Pollutants From Water Using Sewage Sludge Based Composite Adsorbents, Rui Ding

Dissertations, Theses, and Capstone Projects

Millions of tons of sewage sludge, waste oil sludge and fish waste are produced annually, and improper treatment/disposal of these wastes have resulted in numerous environmental issues. On the other hand, these wastes are rich in organic materials, metals, and inorganic minerals and could be sustainable resources if utilized properly. The main purpose of this dissertation study was, therefore, to convert these wastes into composite adsorbents, and then use these adsorbents to remove various types of organic pollutants, emerging organic contaminants in particular, from wastewater and drinking water sources.

It is hypothesized that a hydrophobic carbon phase in the composite …

Overpopulation And The Impact On The Environment, Doris Baus

Dissertations, Theses, and Capstone Projects

In this research paper, the main focus is on the issue of overpopulation and its impact on the environment. The growing size of the global population is not an issue that appeared within the past couple of decades, but its origins come from the prehistoric time and extend to the very present day. Throughout the history, acknowledged scientists introduced the concept of “overpopulation” and predicted the future consequences if the world follows the same behavioral pattern. According to predictions, scientists invented the birth control pill and set population control through eugenics. Despite that, population continued to increase and fight with …

As If By Magic: Unleashing Critical And Expressive Voices Through A Rhetoric Of "This/And" In First-Year Composition, Nolan Chessman

Dissertations, Theses, and Capstone Projects

This dissertation engages academic, creative, and student genres in conversation in order to challenge the strict discursive and stylistic boundaries placed around college writing, particularly in first-year composition. Because this project aims to thrust first-year writing pedagogy beyond the confines of fixed genre forms, its inquiry is multimodal, intermingling writing styles and research modes so that, in scholar-teacher Wendy Bishop’s words, “I can think in and through them all” (“Places to Stand” 17). The particulars—or “data”—informing this study are primarily archival, textual (often a combination of the two), experimental, and experiential. Broadly speaking, this inquiry consists of seven chapters, which …

American Civil Associations And The Growth Of American Government: An Appraisal Of Alexis De Tocqueville’S Democracy In America (1835-1840) Applied To Franklin D. Roosevelt's New Deal And The Post-World War Ii Welfare State, John P. Varacalli

Dissertations, Theses, and Capstone Projects

In Democracy in America, Alexis de Tocqueville (1805-1859), a French aristocrat, intellectual, and commentator on American society during the 1830’s, described the United States as a society marked by a general “equality of condition,” that is, by a lack of noticeable social and economic distinctions among the citizenry. For Tocqueville, this characteristic of democracy encouraged the formation of an informal political bloc he termed “the majority” - a group who would often elect demagogues to political offices, since the latter were best able to give voice to majority opinion. Furthermore, de Tocqueville believed that this group was not only …

The Effect Of A Single Bout Of Physical Exertion On Expressive Language And Word Finding In Individuals With Multiple Sclerosis, Marissa A. Barrera

Dissertations, Theses, and Capstone Projects

To date, little research has been conducted on the relationship between fatigue and expressive language among Multiple Sclerosis patients (MS). This study was a response to this knowledge gap. A nonrandom, matched- subject, mixed-factor design model was used with a purposive sample of 17 individuals with MS (five had primary-progressive (PP) MS, and 12 had relapsing-remitting (RR) MS). The research design was subjected to pretesting to ensure validity. Participants were assessed on a range of language tasks after undergoing one bout of cardiovascular exercise (NuStep T5 Recumbent Cross Trainer) and asked to provide a subjective fatigue score. The expressive language …

Physical Mechanisms And Biological Consequences Of Voltage-Gated Sodium Channel Modulation By Fhf Proteins, Yue Liu

Dissertations, Theses, and Capstone Projects

Purpose: FHFs are cytosolic proteins that bind to voltage-gated sodium channels (Na_Vs) and modulate their functions to control membrane excitability. FHFs raise the voltage dependence of Na_V fast inactivation to promote excitability, while A isoforms FHF (A-FHFs) also capture open sodium channels into a long-term inactivated (LTI) state to limit excitability. My research has addressed how FHFs balance membrane excitability as it relates to normal and pathological brain functions. Part of this work stemmed from the discovery of a missense FHF1 mutation in patients with severe early onset epilepsy. Methods and Results: Wild-type FHF1A and FHF1B were …

Post-Transcriptional Regulation Of The Drosophila Anterior Determinant, Bicoid, John Mclaughlin

Dissertations, Theses, and Capstone Projects

In a wide variety of biological contexts, messenger RNA (mRNA) is known to have a complex and dynamic life cycle. In particular, the localization and translational control of mRNA are essential for proper development in eukaryotes. The fly Drosophila melanogaster is an excellent model for studying these processes. During D. melanogaster oogenesis, several mRNAs are trafficked and localized within the developing egg chamber, and regulated at the translational level to enable embryo patterning. One such mRNA, bicoid, is localized at the anterior of the oocyte and translated in the early embryo, where its encoded protein directs formation of the fly's …

The Fantastic Manifesto: Monstrosity Of Memory And Epiphany Of Selfhood In The Spirit Of The Beehive (1973), Layla Blodgett Carrillo

Dissertations, Theses, and Capstone Projects

The Spanish culture of storytelling suffered under the nearly forty-year dictatorship of Francisco Franco. The government-regulated cinema welcomed propaganda and melodrama, and denied the fantastic, the legendary, and the magical. These carefully manipulated histories, which served to romanticize the ideologies of the regime, also served to eulogize the delinquent and the depraved. In the early 1970s, at the heels of the collapse of Franco’s reign, the people of Spain bore witness to a new national cinema. The Spirit of the Beehive (1973), the feature debut from Victor Erice, exists at the threshold between a storied history of Spanish dictatorship and …

Sex Differences In The Anxiety Effects Of Cannabinoids, Helen T. French

Dissertations, Theses, and Capstone Projects

Aim: Anxiety disorders are twice as common among women, and those with anxiety disorders are 2-3 times more likely to have a substance abuse disorder than the general populace. However, little data exists on the sexually dimorphic effects of cannabinoids. In male humans and rodents, low acute doses of cannabinoids are anxiolytic while high and/or chronic doses are anxiogenic. In the dose response curve (DRC), we examined whether the biphasic effects of cannabinoids observed in males are also present in females. In the CB1R antagonism study, CP55,940-induced CB1R activation was antagonized via the CB1R-selective antagonist rimonabant to test the hypothesis …

Estradiol, Substance P, And The Pi3k-Akt-Mtor Pathway In The Dorsal Horn Of The Spinal Cord During Inflammatory Pain, Zane Ferguson

Dissertations, Theses, and Capstone Projects

Pain is a critical survival mechanism that signals potential or actual damage, but it can become pathological when it persists beyond the injury. Chronic pain is a major health issue that affects 10-20% of the adult population and is found disproportionately in women. There are numerous, interacting mechanisms underlying this phenomenon. This study used female rats to investigate the impact of estrogens on sensory signaling by substance P, a neuropeptide that contributes to the development of chronic pain, and the PI3K-Akt-mTOR pathway, an intracellular mechanism of nervous system plasticity.

Second Harmonic Generation – A Novel Approach In Retinal Imaging, Denis Y. Sharoukhov

Dissertations, Theses, and Capstone Projects

Here we present the utilization of Second Harmonic Generation (SHG) for label-free imaging of microtubules (MTs) in the retinal nerve fiber layer (RNFL). MTs are an important part of axonal cytoskeleton, providing structural support and serving as a railroad in intracellular transport. We demonstrate the application of SHG microscopy to the following studies: 1) Can changes in MT conformation be detected when treated with a stabilizing drug (Taxol); 2) if disruption in MT precedes loss of axons in a mouse model of glaucoma (DBA/2J); and 3) if elevated levels of intraocular pressure affect MT integrity. Our results validate SHG imaging …

Capitalism And Unfreedom: Louis D. Brandeis And A Liberty Of The Left, Eric L. Apar

Dissertations, Theses, and Capstone Projects

The American Right features a well-developed—and well-heeled—infrastructure for promoting a conception of freedom as inextricable from capitalism. The American Left, by contrast, has seemed content to cede the territory, abandoning the ground of freedom for the terrain of “equality,” “justice,” “fairness,” and “prosperity.” This paper is an effort to address this asymmetry in the public discourse over the meaning of freedom. Its principal objective is to capture the vision of freedom embodied in the political and economic thought of Louis D. Brandeis, one of the American Left’s ablest expositors of freedom.

In addition, the paper has three subsidiary objectives. The …

Environmental Changes Turn On The Sinorhizobium Melitloti Exor-Exos/Chvi (Rsi) Host Invasion Switch, Shari N. Walcott

Dissertations, Theses, and Capstone Projects

The free-living Gram-negative soil bacterium, Sinorhizobium meliloti, must switch into its host-invading form in order to infect the root hairs of the host plant, alfalfa (Medicago sativa), and establish a nitrogen-fixing symbiosis. The activation of the switch is believed to occur inside the infection chamber that is formed by curling of the root hairs. It is not fully understood what signals in the environment of the root hairs trigger and infection chamber S. meliloti to switch into a host-invading form since these signals were not extensively examined until now. This switch can be observed directly, due to …