Digital Commons Network^™

The Labyrinth And The Cave: Archaic Forms In Art And Architecture Of Europe, 1952–1972, Paula Burleigh

Dissertations, Theses, and Capstone Projects

This dissertation examines the prevalence of spatial archetypes as potent symbols that manifested in art, architecture, exhibition design, and urban planning in the aftermath of World War II and into the Cold War. Owing to the dual influence of structuralism and phenomenology in French intellectual culture, many examples discussed here were produced in France or made by artists who spent significant time there. These figures include Jacqueline de Jong, Paul Virilio, Claude Parent, André Bloc, and the Groupe de Recherche d’Art Visuel (GRAV), all of whom made projects evoking speculative realities that oscillated between utopian and dystopian.

Given their focus …

The Threats Of Sea Level Rise: An Eco-Geopolitical Visual Analysis, Jorge L. Nowell-Enriquez

Dissertations, Theses, and Capstone Projects

This eco-geopolitical research produces information about the sea level rising, and the analyst explains and projects global effects, and further problems and consequences of the phenomena in a five-minute-long video clip.

The focus is coastlines floods as a consequence of the sea level rising produced by glaciers melting. The floods will affect regions where over a billion persons are living, mainly coastal cities. Therefore, the sea level rising will produce or ease gradual destruction and sudden catastrophes. Moreover, these catastrophes will spur mass migration that might change the lives of a billion persons by 2045.

Renal Risk Variants Of Apolipoprotein L-1 Form Channels At The Plasma Membrane That Lead To A Cytotoxic Influx Of Calcium, Joseph A. Giovinazzo

Dissertations, Theses, and Capstone Projects

Apolipoprotein L-1 (APOL1) is a secreted protein that provides protection against several protozoan parasites due to its channel forming properties. Recently evolved variants, G1 and G2, increase kidney disease risk when present in two copies. In mammalian cells, overexpression of G1 and G2, but not wild-type G0, leads to swelling and eventual lysis. However, the mechanism of cell death remains elusive with multiple pathways being invoked, such as autophagic cell death mediated by a BH3 domain in APOL1, which we evaluated in this study. We hypothesized that the common trigger for these pathways is the APOL1 cation channel, which is …

Curcumin Inhibits The Ikk:Nf-Kappa B Pathway In Neural Fear Circuits, Miguel A. Briones

Dissertations, Theses, and Capstone Projects

The study of how the brain acquires fearful memories has attracted considerable experimental attention, due in part to the promise of discovering novel therapeutic approaches for psychiatric disorders that are characterized by unusually strong and persistent traumatic memories. In recent years, extensive research has focused on studying the neural and molecular mechanisms by which fear memories are acquired, stored, and retrieved in the brain. Once acquired, fear memories may be attenuated using one of 2 procedures: 1) fear extinction, which involves repeated presentation of the fear-arousing stimulus in the absence of an aversive consequence, or 2) interference with the reconsolidation …

Unusual Accidental Signs, Microtonal Inflections, And Marchetto Of Padua, Alan D. Richtmyer

Dissertations, Theses, and Capstone Projects

This thesis addresses the question of how an interval roughly half the width of the minor semitone could be incorporated into the otherwise strictly diatonic framework of the medieval gamut and then asks whether certain unusual accidentals signs found in fourteenth- and early fifteenth-century sources were meant to signal such inflections.

It demonstrates that when a tone is subdivided so as to produce a microtone, the chromatic part that remains must either be made explicit, or must be transferred elsewhere in the scale so that the encompassing framework of the gamut will remain intact. It shows that when the former …

Underlying Contribution Of Executive Functioning To Cognition And Academic Achievement In Individuals With Dystrophinopathy, Robert Fee

Dissertations, Theses, and Capstone Projects

Dystrophinopathy is a genetic disorder that results in the lack of or abnormal expression of the protein dystrophin. It is a disorder that alters cell structure and function, impacts the developing brain and brain function, presents with multi-domain cognitive deficits, and influences both mood and behavior. Cognitive impairments appear to be more localized to specific areas of functioning rather than a global deficit; however, deficits have been identified across multiple cognitive domains including language and aspects of executive functioning. A careful examination of the cognitive phenotype and its association to mutations affecting CNS isoforms is necessary to clarify the neuropsychological …

Critical Paradigm Theory: A Deconstruction Of The Dominant Discourse Shaping Public Education In America, Kevin Froner

Dissertations, Theses, and Capstone Projects

The purpose of this study was to deconstruct the dominant discourses shaping public education in America. To understand the ontological and genealogical roots of public education, the researcher developed a framework referred to as Critical Paradigm Theory (CPT) to examine the current education paradigm. Longitudinal data was collected from the National Center for Education Statistics (NCES) with an analysis of the Programme for International Student Assessment (PISA), Trends in International Mathematics and Science Study (TIMSS), Progress in International Reading Literacy Study (PIRLS), and the National Assessment of Educational Progress (NAEP).

Additional analysis was performed applying critical paradigm theory to a …

Resting-State Functional Connectivity In Youth With Gender Dysphoria, Felix L. Garcia

Dissertations, Theses, and Capstone Projects

Current developmental models of gender identity and gender dysphoria (GD) lack sex-specific profiles of brain function that differentiate between typically-developing and cross-gender identified youth, as postulated by models like the unified theory of the origins of sex differences (Arnold, 2009) and the neurobiological theory of the origins of transsexuality (Swaab & Garcia-Falgueras, 2009). Previously, investigators have used brain imaging modalities such as Resting-State functional Magnetic Resonance Imaging (R-fMRI) to demonstrate differences in resting-state functional connectivity (RSFC) between typically-developing male and female youth, and between typically-developing and GID-diagnosed youth. In the present pilot study, I used R-fMRI to investigate differences in …

Morality As Social Software, Jongjin Kim

Dissertations, Theses, and Capstone Projects

The dissertation research is a project to understand morality better through the concept of ‘Social Software.’ The dissertation is, consequently, to argue that the morality in a human society functions as a form of social software in the society. The three aspects of morality as social software are discussed in detail: the evolutionary, anti-entropic, and epistemic game-theoretic aspect.

We humans ‘usually’ think that, for example, (a) killing other humans without any necessary reason is morally wrong, and (b) helping other humans in need is morally right. We want to know, in this dissertation research project, why we think in such …

Sex And The Single Feminist Science Fiction Scholar, Marleen S. Barr

Publications and Research

In the AAUP magazine ACADEME, feminist science fiction scholar Marleen S. Barr discusses her past in light of #MeToo.

The Impact Of Perineuronal Net Digestion Using Chondroitinase Abc On The Intrinsic Physiology Of Cortical Neurons, Philip Chu, Reena Abraham, Kumarie Budhu, Usma Khan, Natalie De Marco Garcia, Joshua C. Brumberg

Publications and Research

Perineuronal nets (PNNs) are a form of aggregate Extracellular Matrix (ECM) in the brain. Recent evidence suggests that the postnatal deposition of PNNs may play an active role in regulating neuroplasticity and, potentially, neurological disorders. Observations of high levels of PNNs expression around somas, proximal dendrites, and axon initial segments of a subtype of neurons have also led to proposals that PNNs may modulate the intrinsic properties of the neurons they ensheathe. While high levels of PNNs are postnatally expressed throughout the neocortex, it is still unclear how they impact the neuronal physiology of the many classes and subtypes of …

Development And Transfer Of Technological Pedagogical Content Knowledge (Tpack) Of Special Education Teachers, Aleksandra A. Kaplon-Schilis

Dissertations, Theses, and Capstone Projects

This dissertation presents findings of three studies investigating the development and transfer of TPACK of pre-service and in-service elementary school special education teachers. The dissertation is presented in a non-traditional format including an introduction, three manuscripts submitted for journal publication, and a summary chapter. The purpose of the first study was to analyze development of TPACK of pre-service elementary special education teachers enrolled in a graduate level pedagogy course Integrating Technology in Mathematics and Science Instruction in Special Education and Inclusive Classrooms in a New York City public college. The study’s research question was to find out whether the TPACK- …

Synthesis And Characterization Of Cytocompatible Sponge-Mimetic Scaffolds And Biomedical Polymers, Kamia Punia

Dissertations, Theses, and Capstone Projects

This dissertation describes the novel synthetic methodologies towards: a) protein/polysaccharide intercalated sponge-mimetic scaffolds for 3D cell culture, b) peptide-mimetic cationic amphiphilic antibacterial polymers, and c) bioactive Poly(DL-lactide-co-glycolide) (PLGA) nanofibers by solution blow spinning for the treatment of cancer and traumatic wound care.

The classic “chemical garden” experiment is reconstructed to produce protein/polysaccharide (ingredients of cyanobacterial origin) intercalated silicate-phosphate tubules that resemble tubular sponges. The constructs were synthesized by seeding calcium chloride into a solution of sodium silicate-potassium phosphate and gelatin/polysaccharides. The morphology and composition of sponge-mimetic tubules were analyzed by a battery of techniques. Bioconjugation and coating protocols were developed …

Modern Arts And Pueblo Traditions In Santa Fe, 1909–1931, Elizabeth S. Hawley

Dissertations, Theses, and Capstone Projects

This dissertation examines art produced in and around Santa Fe, New Mexico during the early twentieth century, putting the works of Pueblo artists who lived in the area into dialogue with the works of Anglo-American modernists who traveled there. I take as case studies three artists whose practices are linked by both circumstance and agenda: Maria Martinez, a famed Pueblo potter; John Sloan, a leading member of The Eight and the Ashcan School; and Tonita Peña, a Pueblo watercolor painter. Weaving together Anglo-American and American Indian art history – which are too often bifurcated into separate accounts, omitting rich histories …

Synthesis And Evaluation Of Densely-Functionalized Troponoids, Danielle R. Hirsch

Dissertations, Theses, and Capstone Projects

Herein, we document our efforts to expand the scope of troponoid synthetic methodology towards densely-substituted scaffolds. This body of work has focused primarily on an oxidopyrylium cycloaddition/ring-opening strategy for the synthesis and biochemical evaluation of troponoids for assistance in a variety of medicinal chemistry studies. In Chapter 1, we outline the use of this synthetic strategy in the profiling of a library of synthetic αHTs against an aminoglycoside antibiotic resistance enzyme known as aminoglycoside-2’’-O-nucleotidyltransferase [ANT(2’’)-Ia]. Enzymatic mechanistic insights have been gleaned from an assessment of troponoid/antibiotic synergistic potential. In particular, two synthetic constructs were identified as promising antibiotic adjuvant candidates, …

Can Mindfulness Training Reduce Stress Reactivity In First-Year College Students?, Liat Zitron

Dissertations, Theses, and Capstone Projects

ABSTRACT

Can Mindfulness Training Reduce Stress-Reactivity in First-Year College Students?

By

Liat Zitron

Advisor: Yu Gao, PhD

The positive effects of mindfulness-based practices on stress reactivity have been gaining steady attention in recent years. Yet, the effects of mindfulness training on stress responses via the autonomic nervous system (ANS) functioning, and in particular, changes in cardiovascular activity, have rarely been researched. The polyvagal theory (Porges, 1995) offers a theoretical framework in which the roles of the subdivisions of the ANS in regulating emotion and behaviors are delineated, and closely connected to the concept of heart rate variability (HRV) and its …

Software Of The Oppressed: Reprogramming The Invisible Discipline, Erin R. Glass

Dissertations, Theses, and Capstone Projects

This dissertation offers a critical analysis of software practices within the university and the ways they contribute to a broader status quo of software use, development, and imagination. Through analyzing the history of software practices used in the production and circulation of student and scholarly writing, I argue that this overarching software status quo has oppressive qualities in that it supports the production of passive users, or users who are unable to collectively understand and transform software code for their own interests. I also argue that the university inadvertently normalizes and strengthens the software status quo through what I call …

Diagnosing The Will To Suffer: Lovesickness In The Medical And Literary Traditions, Jane Shmidt

Dissertations, Theses, and Capstone Projects

Throughout Western medical history, unconsummated, unreturned, or otherwise failed love was believed to generate a disorder of the mind and body that manifested in physiological and psychological symptoms. This study traces the medical and literary history of lovesickness from antiquity through the 19^th century, emphasizing significant moments in the development of the medical discourse on love. The project is part of the recent academic focus on the intersection between the humanities and the medical sciences, and it situates literary texts in concurrent medical and philosophical debates on afflictions of the psyche. By contextualizing the fictional works within the scientific …

The Essential New York City Films, Nikola M. Durkovic

Dissertations, Theses, and Capstone Projects

Films play significant part in the creation and preservation of the New York City’s image and must be consulted by anyone interested in exploring the City’s history and character. The essential New York films tell stories about New Yorkers and how they deal with their reality of extreme diversity and competition. In my opinion, there are six essential New York City films: Shadows (1959), The Panic in Needle Park (1971), Mean Streets (1973), Taxi Driver (1976), Manhattan (1979), and 25th Hour (2002). My goal is to explore the essential New York films and demonstrate how their content and form reflect …

Domain-Specific Knowledge Exploration With Ontology Hierarchical Re-Ranking And Adaptive Learning And Extension, Grace G. Zhao

Dissertations, Theses, and Capstone Projects

The goal of this research project is the realization of an artificial intelligence-driven lightweight domain knowledge search framework that returns a domain knowledge structure upon request with highly relevant web resources via a set of domain-centric re-ranking algorithms and adaptive ontology learning models. The re-ranking algorithm, a necessary mechanism to counter-play the heterogeneity and unstructured nature of web data, uses augmented queries and a hierarchical taxonomic structure to get further insight into the initial search results obtained from credited generic search engines. A semantic weight scale is applied to each node in the ontology graph and in turn generates a …

Digesting Democracy: A Theoretical Analysis Of American Food Regimes, Angela R. Moore

Dissertations, Theses, and Capstone Projects

This analysis will explore the theoretical underpinnings of the neoliberal food regime in relation to American democracy, and how an alternative food regime of food sovereignty may help to expand American democracy. The latter regime has an integrative approach to promote democracy through realigning the food system with collective decisions at its base instead of distancing the people from food and providing the opportunity for a self-ruling demos to collectively govern. Food sovereignty with its processes of participation, community responsibility, and self-determinism may challenge the current American democracy by using the framework of food regime theory. In the conclusion of …

Territories Of Contestation In Medellín: Destierro, Memory, The Youth, And The State, Joan C. Lopez

Dissertations, Theses, and Capstone Projects

This thesis is partly a study of the social and political territories that are generated by the displaced as responses to the warfare tactic of el destierro (displacement); and it is also an exploration of how the state operates at the intersection between its imagined centers and its margins. This thesis attempts to look at the state from its imagined margins and to explore how displacement, the regulation of the movement of specific bodies within and across specifically defined regions of Colombia, has been a fundamental practice for, and not against, the formation of the Colombian “state” as we see …

Manifest Density: Decentering The Global Western Film, Michael D. Phillips

Dissertations, Theses, and Capstone Projects

The Western is often seen as a uniquely American narrative form, one so deeply ingrained as to constitute a national myth. This perception persists despite its inherent shortcomings, among them its inapplicability to the many instances of filmmakers outside the United States appropriating the genre and thus undercutting this view of generic exceptionalism. As the Western has migrated across geographical boundaries, it has accrued potential significations that bring into question its direct alignment with national ideology and history. Rather than attempting to define the Western in terms of nation or myth, we should attend to how each new text reconfigures …

Ulva Spp. Bloom Dynamics In A Hyper-Eutrophic Estuary: Jamaica Bay, New York, Annesia Lamb

Dissertations, Theses, and Capstone Projects

In this dissertation, I present three studies that further our understanding of macroalgae identity, growth, and proliferation. Eutrophication is prevalent in shallow coastal ecosystems world-wide. One of the ecosystem consequences is the development of a bloom forming green marine macroalgae, Ulva spp. Ulva can have negative effects such as Zostera spp. degradation, fish, and shellfish declines. I performed assessments of (1) identity of the bloom-forming Ulva and other macroalgae assemblage, (2) physical, chemical, and biological drivers of Ulva bloom growth and proliferation, and (3) optimal irradiance and temperature requirements for early growth stages in Ulva linza.

The first study …

Resonant Texts: The Politics Of Nineteenth-Century African American Music And Print Culture, Paul Fess

Dissertations, Theses, and Capstone Projects

Resonant Texts: the Politics of Nineteenth-Century African American Music and Print Culture, investigates musical sound as a discursive tool African American writers and activists deployed to contest enslavement before the Civil War and claim citizenship after Emancipation. Traditionally, scholars have debated the degree to which nineteenth-century African American music constituted evidence of black culture and marked a persistent African orality that still abides within African American textual production. While these trends inform this project, my inquiry focuses on the ways that writers placed elements of musical sound—such as rhythm, melody, choral singing, and harmony—at the center of their …

Increasing Access To Pre-Exposure Prophylaxis (Prep) Among Transgender Women And Trans Feminine Non-Binary Individuals In New York City, Augustus Klein

Dissertations, Theses, and Capstone Projects

In the United States transgender women (i.e., individuals born male whose gender identity is on the feminine spectrum) are a highly vulnerable and marginalized population at high risk for HIV. Substance use, survival sex work, depression, unstable housing, and high levels of victimization and violence are commonly reported by transgender women and trans feminine individuals, indicating the potential for multiple concurrent HIV risks and underlying vulnerabilities. Structural forms of discrimination may contribute to these risk factors, possibly leading to poor outcomes such as unemployment or underemployment, homelessness, and lack of access to gender-affirming health care. Given this context, a biomedical …

Demystifying The Placebo Effect, Phoebe Friesen

Dissertations, Theses, and Capstone Projects

This dissertation offers a philosophical analysis of the placebo effect. After offering an overview of recent evidence concerning the phenomenon, I consider several prominent accounts of the placebo effect that have been put forward and argue that none of them are able to adequately account for the diverse instantiations of the phenomenon. I then offer a novel account, which suggests that we ought to think of the placebo effect as encompassing three distinct responses: conditioned placebo responses, cognitive placebo responses, and network placebo responses. Next, I consider implications of the placebo effect’s role in complementary and alternative medicine for discussions …

The Development Of Novel Platforms For The Imaging Of Cancer By Positron Emission Tomography, Brendon E. Cook

Dissertations, Theses, and Capstone Projects

The role of antibody-based imaging of cancer by positron emission tomography (PET) has expanded significantly in recent years and is poised to radically alter the way that cancer is diagnosed and treated. However, one hurdle that remains is the potentially harmful radiation dose that comes from these imaging agents, as the long circulation time of antibodies (days to weeks) necessitates the use of radionuclides with comparable physical half-lives (i.e. ⁸⁹Zr, ¹²⁴I, etc.). One particularly promising solution is the use of the inverse electron demand Diels-Alder (IEDDA) reaction between a 1,2,4,5-tetrazine (Tz) and a trans-cyclooctene (TCO) for pretargeting. …

Detecting Cognitive, Functional And Behavioral Response To Donepezil In Alzheimer’S Disease: The Role Of Attention Tasks, Clara Vila-Castelar

Dissertations, Theses, and Capstone Projects

Introduction: Cholinesterase Inhibitors (ChEIs) used in Alzheimer’s Disease (AD) have modest effects, heterogeneous treatment response, and it has been difficult to detect treatment response. The standard research and clinical outcome measure, the Alzheimer’s Disease Assessment Scale-Cognitive subscale (ADAS-Cog) aggregates multiple cognitive domains, and has limited sensitivity. We propose that because acetylcholine is directly linked to the cognitive domain of attention, and ChEIs increase available acetylcholine, measures of attention under high-load conditions could predict long-term cognitive, functional and behavioral response, and thus, unlike global measures, could be sensitive to treatment efficacy.

Method: We conducted a longitudinal, open label donepezil trial …

Integration Of Bmp And Insulin/Igf-1 Signaling Regulates Multiple Homeostatic Functions In Caenorhabditis Elegans, James F. Clark

Dissertations, Theses, and Capstone Projects

The maintenance of homeostatic functions is key to the survival and well-being of an organism. Regulation of homeostasis relies on varied inputs, both intrinsic and extrinsic, to potentiate a web of interconnected signaling relays. Insulin/IGF-1 signaling (IIS) is a well-known regulator of glucose and lipid metabolism, as well as having far reaching effects in other homeostatic mechanisms. On the other hand, bone morphogenetic protein (BMP), a member of the transforming growth factor beta signaling superfamily, is known for its role in differentiation and development, with only recent studies highlighting potential roles in metabolic homeostasis. Here we elucidate new functions for …