Digital Commons Network^™

Characterization Of Early Biofilm Formation And Physiology In Neisseria Gonorrhoeae, Kelly Eckenrode

Dissertations, Theses, and Capstone Projects

Many bacteria rely on the dynamics of their extracellular appendages to perform important tasks, like motility and biofilm formation. Interestingly, these dynamics have been linked to physiological responses in some pathogenic bacteria; therefore, it is important to understand more about the role of physical forces in bacteria. I used the causative agent of the human disease gonorrhea, Neisseria gonorrhoeae, as a model system to study the role of physical force on early biofilm formation. The advantage of this system is that cell-cell interactions are controlled by extracellular filaments called type IV pili (tfp). Tfp is composed of monomers that give …

Probing The Gelation Phenomena In Molecular And Seed-Based Gels, Malick Samateh

Dissertations, Theses, and Capstone Projects

The interest in molecular gels has been gaining momentum as evident from being developed for a broad spectrum of applications. This impetus stems from several reasons that include: (i) molecular gels are highly stimuli responsive as they easily respond to thermodynamic changes, disintegrating into well-defined chemicals/building blocks because of the purely physical (in contrast to chemically cross-linked) nature of the interactions holding their 3D networks together; (ii) the sheer abundance of simple small molecules to choose starting materials from and the vast potential of tunability of the low molecular weight gelators (LMWGs) make the LMWGs and the molecular gels highly …

Rich In Needs: The Forgotten Radical Politics Of The Welfare Rights Movement, Wilson Sherwin

Dissertations, Theses, and Capstone Projects

Situated temporally between the Civil Rights Movement and the Women’s Movement, the Welfare Rights Movement of the 1960s and 70s distinguished itself by its militant critique of waged labor. Returning to the movement’s archives I examine how the mostly poor, Black, female participants developed their “antiwork politics”, how they asserted their right to live not only meager but occasionally luxurious lives—demanding not only bread but also roses. In the courts, streets, welfare offices, department stores, policy proposals, and numerous internal debates, these women waged national battles to assert full autonomy over their families, consumption, sexuality, and their own time.

As …

The Evolution Of Reproductive Complexity In Fishes, Frieda Benun

Dissertations, Theses, and Capstone Projects

How does reproductive complexity evolve? In this dissertation, I investigate the evolution of parental investment and mating behavior, using both macro- and microevolutionary lenses. I use fishes, the most diverse group of vertebrates, comprising over 30,000 species, as a model to study the evolution of these traits.

In Chapter 1, I introduce the evolution of parental behaviors in fishes. I present a systematic review of parental care for 294 families (close to 60%) of bony fish and show that male-only care is the predominant form of care in this group. I summarize current theories on parental care, emphasizing external fertilization, …

Staging English Affairs In Early Modern Italy: History, Politics, Drama, Fabio Battista

Dissertations, Theses, and Capstone Projects

This dissertation looks at the creation and dissemination of alternative versions of English history through the means of dramatic fiction, and contextualizes them in the panorama of the intellectual debates of seventeenth-century Italy. Staging English Affairs in Early Modern Italy studies the ways in which the reinvention of Tudor and Stuart affairs in dramatic literature mirrored the ambitions, fears, and fantasies of a century in disquieting transformation. This research documents how news and information from England entered the Italian states, how they were perceived, and what their repurposing can reveal about the potentialities of intercultural exchange. Anglo-inspired drama became a …

Renal Specific Rnai Delivery By Fibrillar Nanoparticle Excipients, Sam Wong

Dissertations, Theses, and Capstone Projects

RNA interference (RNAi) is a powerful tool to manipulate the phenotype of an organism by silencing the expression of specific genes and is viewed as a highly promising platform for treating undruggable targets and disorders where small molecule drugs and antibodies would fail. However, development of RNAi based therapies has faced major barriers including cellular and tissue-specific uptake of the Small Interfering RNA (siRNA). Utilizing different nanoparticles as RNAi excipients, cellular uptake and gene silencing potency can be greatly improved. The research in Dr. McDevitt groups has fibrillar carbon nanotubes (CNT) as carriers for siRNA for gene silencing in vitro …

Systematics Of Carex Section Laxiflorae (Cyperaceae), Jenna Dorey

Dissertations, Theses, and Capstone Projects

Carex, with more than 2100 species, is the most species-rich genus of flowering plants in temperate regions of the world. Members of the family Cyperaceae are colloquially known as sedges, and members of the genus Carex are called “true sedges.” Carex occur on every continent except for Antarctica, they thrive in a panoply of habitats, and are ecologically important as a forage source for wildlife, carbon sequestration, prevention of soil erosion, and providing habitat for fresh water invertebrates. Despite their importance many sedges are still poorly known, such as the woodland sedges in Carex section Laxiflorae, which is …

Love And Revolution: Queer Freedom, Tragedy, Belonging, And Decolonization, 1944 To 1970, Velina Manolova

Dissertations, Theses, and Capstone Projects

This dissertation examines literary works by U.S. writers Lillian Smith, Carson McCullers, James Baldwin, and Lorraine Hansberry written in the early part of the postwar period referred to as the “Protest Era” (1944-1970). Analyzing a major work by each author—Strange Fruit (1944), The Member of the Wedding (1946), Giovanni’s Room (1956), and Les Blancs (1970)—this project proposes that Smith, McCullers, Baldwin, and Hansberry were not only early theorists of intersectionality but also witnesses to the deeply problematic entanglements of subjectivities formed by differential privilege, which the author calls intersubjectivity or love. Through frameworks of queerness, racialization, performance/performativity, tragedy, and …

Voluntary Oral Methamphetamine Reveals Susceptibilities To Spatial Memory Deficits, Decreased Dopamine Marker Expression And Increased Neuroinflammation In The Hippocampus Of Male And Female Mice, Jorge A. Avila

Dissertations, Theses, and Capstone Projects

Methamphetamine is an addictive illicit psychostimulant that produces lasting neurochemical and behavioral changes. The mechanisms underlying these deficits have been characterized in animal models using extremely high doses. Currently, better translational models are needed to understand the onset and progression of these deficits that more accurately reflect the gradual and voluntary dosing parameters as chosen by an abuser. To that end, a new model of methamphetamine administration, labeled Voluntary Oral Methamphetamine Administration (VOMA), offers a means to examine the progression of neurotoxicity, behavioral deficits, and the addiction process through a voluntary consumption framework.

Female populations show consistent vulnerabilities to methamphetamine, …

Unlearning Don Carlos: Historical And Fictional Elements Of Innovation In César Vichard De Saint-Réal’S 'Dom Carlos, Nouvelle Historique,' Friedrich Schiller’S 'Don Karlos, Infant Von Spanien,' And Giuseppe Verdi’S 'Don Carlos', Maria-Cristina Necula

Dissertations, Theses, and Capstone Projects

The story of the sixteenth-century Spanish prince, Don Carlos, has inspired numerous literary and musical adaptations that, despite the artistic limitations of historically-based content, reflect an astonishing scope of creative freedom. The myth created around Don Carlos originated in European consciousness as early as 1568. Various theories recorded in political reports and in historical works insinuated that the prince had been murdered while incarcerated by orders of his father, King Philip II. Simultaneously, hatred of Spain, intensified by Philip’s violent suppression of the revolt in the Netherlands, determined exiled Flemish nobles to launch an anti-Philip propaganda. The mystery of Don …

Market Making: Crises And The Global Production Of Shipbreaking In Chittagong, Bangladesh, Elizabeth A. Sibilia

Dissertations, Theses, and Capstone Projects

Shipbreaking is a dismantling process with a primary objective of extracting large amounts of steel from ocean-going vessels, oil tankers, bulk cargo carriers, and container ships. As mobile forms of fixed capital, these devalued vessels have experienced a gradual or sudden loss of value. The removal of devalued ships from the world fleet, through an increasingly sophisticated global demolition market and expanding domestic shipbreaking markets, have played a critical role in helping the global shipping sector solve its crises of overproduction since the mid 1970s. Since the early 1990s Bangladesh has become one of the most important domestic shipbreaking markets. …

Textframe: Cosmopolitanism And Non-Exclusively Anglophone Poetries, Michael N. Scharf

Dissertations, Theses, and Capstone Projects

This project proposes a replacement for some institutional-archival mechanisms of non-exclusively anglophone poetry as it is produced under racial capitalism and archived via its universities and grant-bearing nonprofits. The project argues specifically for the self-archiving of non-exclusively anglophone poetry, and by extension of poetry, in a manner that builds away from US-dominated, nationally-organized institutions. It argues that cosmopolitanist norm translation, as advocated by various critics, can function as part of a critique of institutional value creation used in maintaining inequalities through poetry. The US-based Poetry Foundation is currently the major online archive of contemporary anglophone poetry; the project comprises a …

Eugenics In The 21st Century, Jessica Linn Chin

Dissertations, Theses, and Capstone Projects

Eugenics is the science of enhancing the human population through the management of breeding and hereditary traits. This thesis explores the history of eugenics and shows how eugenic practices continue in the 21^st century with advancements in technology and positive eugenic goals that can result in adverse effects on the human body and society. When Sir Francis Galton coined the term eugenics in 1883, he intended to improve British society with the use of positive eugenics. Galton used positive eugenics to encourage people with good mental and physical qualities to produce more children. He avoided negative eugenics, which involved …

Multi-Scale Predictors Of Parasite Risk In Wild Male Savanna Baboons (Papio Cynocephalus), Bobby Habig, David A.W.A.M. Jansen, Mercy Y. Akinyi, Laurence R. Gesquiere, Susan C. Alberts, Elizabeth A. Archie

Publications and Research

Several factors are thought to shape male parasite risk in polygynous and polygynandrous mammals, including male-male competition, investment in potentially immunosuppressive hormones, and dispersal. Parasitism is also driven by processes occurring at larger scales, including host social groups and populations. To date, studies that test parasite-related costs of male behavior at all three scales—individual hosts, social groups, and the host population—remain rare. To fill this gap, we investigated multi-scale predictors of helminth parasitism in 97 male savanna baboons (Papio cynocephalus) living in the Amboseli ecosystem in Kenya over a 5-year span. Controlling for multi-scale processes, we found that many of …

Development And Sensory Experience Dependent Regulation Of Microglia In Barrel Cortex, Joshua C. Brumberg, John Kalambogias, Chia-Chien Chen, Safraz Khan, Titus Son, Carolyn Headlam, Cindy Lin

Publications and Research

The barrel cortex is within the primary somatosensory cortex of the rodent, and processes signals from the vibrissae. Much focus has been devoted to the function of neurons, more recently, the role of glial cells in the processing of sensory input has gained increasing interest. Microglia are the principal immune cells of the nervous system that survey and regulate the cellular constituents of the dynamic nervous system. We investigated the normal and disrupted development of microglia in barrel cortex by chronically depriving sensory signals via whisker trimming for the animals’ first postnatal month. Using immunohistochemistry to label microglia, we performed …

Commmunity, Ecology, And Modernity: Faunal Analysis Of Skútustaðir In Mývatnssveit, Northern Iceland, Megan Hicks

Dissertations, Theses, and Capstone Projects

This dissertation examines the archaeofaunal remains from Skútustaðir, a middle to high-status farm in Mývatnssveit, Northern Iceland, to understand the experience of rural communities and their ecologies during Iceland’s transition from regulated colonial exchange to a capitalist economy during the 17^th through 19^th centuries. Archaeofaunal analysis is used to reconstruct changes in the ways that people herded, hunted, and fished, providing insights into how they managed their local environments for subsistence and novel contexts of exchange. In addition to archaeofaunal analysis, primary textual sources are explored to assess how the Skútustaðir household and its rural community mobilized long-term …

Inference Of Language Functional Network In Healthy, Cancerous And Bilingual Brains By Fmri And Network Modeling, Qiongge Li

Dissertations, Theses, and Capstone Projects

We study the underlying mechanism by which language processing occurs in the human brain using inference methods on functional magnetic resonance imaging data. The data analyzed stems from several cohorts of subjects; a monolingual group, a bilingual group, a healthy control group and one diseased case. We applied a complex statistical inference pipeline to determine the network structure of brain components involved with language. This healthy network reveals a fully connected triangular relationship between the pre-Supplementary Motor Area (pre-SMA), the Broca's Area (BA), and the ventral Pre-Motor Area (PreMA) in the left hemisphere. This "triangle'' shows consistently in all the …

The Ethics Of Perception In Transatlantic Romantic Poetry, Charles W. Rowe

Dissertations, Theses, and Capstone Projects

The Ethics of Perception in Transatlantic Romantic Poetry is a report on the ethical significance of British and American Romantic poetry composed between 1785 and 1865. This study focuses on the poems of William Cowper, William Wordsworth, Ralph Waldo Emerson, and Walt Whitman. Its central claim is that these poets composed a body of work that sought to show readers how their sustained attention to everyday perceptual experience could lead them towards a more empathic way of being.

The first chapter argues that the late-eighteenth century poet William Cowper is the initiator of the ethically-oriented poetry of perception that Wordsworth, …

Some Non-Human Languages Of Thought, Nicolas J. Porot

Dissertations, Theses, and Capstone Projects

What might we learn if we take seriously the possibility of non-human Languages of Thought (LoT)? A LoT is a combinatorial set of mental representations. And, since mental representations and rules of combination vary in kind, there are many possible LoTs. Simple LoTs might lack familiar features of the putative human LoT, such as object representations, recursively defined rules of combination, sentential connectives, or predicate-argument structure. The most familiar arguments for the existence of LoTs, such as those from productivity, systematicity, concept learning, and perceptual computation, all fail when applied to non-human animals. But recent empirical evidence motivates attributing LoTs …

Sounds Of Alter-Destiny And Ikonoklast Panzerist Fabulations, Mette Christiansen

Dissertations, Theses, and Capstone Projects

This study is a multifaceted attempt to complicate ideas about study, to think about the critical potential and social implications of certain kinds of stories, and how we might effectively disrupt and reinvent notions and techniques of critique and resistance in the names of hope and social transformation. It looks at the creative practices of Jazz musician and other-worldly being Sun Ra, the dual philosophies of “Ikonoklast Panzerism” and “Gothic Futurism” of an artist known as Rammellzee, and the concept-engineering of theorist and artist Kodwo Eshun, in an attempt to think through how radically unconventional forms of study might make …

The Superstitious Heuristic In Strategic Decision-Making, Jing Liu

Dissertations, Theses, and Capstone Projects

This dissertation focuses on an important but largely ignored phenomenon in the strategic decision literature which I refer to as the use of superstitious heuristics in strategic decision-making. I define the superstitious heuristic as a decision shortcut based on one’s beliefs in the existence of forces or essences that transcend the boundary between the mental/symbolic and physical/material realities in a way that is unsupported by contemporary science. The use ofsuperstitious heuristics in strategic decision-making is prevalent in major economies and influences firms’ strategic behaviors and performance. In this dissertation, I first explored the concept of the superstitious heuristic and …

Law And Society: The Criminalization Of Latinx In The United States, Gabriela Groenke

Dissertations, Theses, and Capstone Projects

The United States leads the world in incarceration with just over 2.2 million people in state or federal prisons or local jails in 2014 (Bureau of Justice Statistics 2016). Although the number of incarcerated individuals has declined by about .5 percent since its peak in 2008 (Bureau of Justice Statistics 2016), the fact remains that mass incarceration is an epidemic in the United States. Over the last decade much has been written about the effects of mass incarceration on people of color, with many analysts pointing to the fear of crime as contributing to the formulation of current policies, which …

Semi-Supervised Regression With Generative Adversarial Networks Using Minimal Labeled Data, Greg Olmschenk

Dissertations, Theses, and Capstone Projects

This work studies the generalization of semi-supervised generative adversarial networks (GANs) to regression tasks. A novel feature layer contrasting optimization function, in conjunction with a feature matching optimization, allows the adversarial network to learn from unannotated data and thereby reduce the number of labels required to train a predictive network. An analysis of simulated training conditions is performed to explore the capabilities and limitations of the method. In concert with the semi-supervised regression GANs, an improved label topology and upsampling technique for multi-target regression tasks are shown to reduce data requirements. Improvements are demonstrated on a wide variety of vision …

Activation Of Lxrβ Inhibits Tumor Respiration And Is Synthetically Lethal With Bcl-Xl Inhibition, Trang Thi Thu Nguyen, Chiaki Tsuge Ishida, Enyuan Shang, Chang Shu, Consuelo Torrini, Yiru Zhang, Elena Bianchetti, Maria J. Sanchez-Quintero, Giulio Kleiner, Catarina M. Quinzii, Mike-Andrew Westhoff, Georg Karpel-Massler, Peter Canoll, Markus D. Siegelin

Publications and Research

Liver-X-receptor (LXR) agonists are known to bear anti-tumor activity. However, their efficacy is limited and additional insights regarding the underlying mechanism are necessary. By performing transcriptome analysis coupled with global polar metabolite screening, we show that LXR agonists, LXR623 and GW3965, enhance synergistically the anti-proliferative effect of BH3 mimetics in solid tumor malignancies, which is predominantly mediated by cell death with features of apoptosis and is rescued by exogenous cholesterol. Extracellular flux analysis and carbon tracing experiments (U-¹³C-glucose and U-¹³C-glutamine) reveal that within 5 h, activation of LXRβ results in reprogramming of tumor cell metabolism, leading …

Deep Machine Learning Techniques For The Detection And Classification Of Sperm Whale Bioacoustics, Peter C. Bermant, Michael M. Bronstein, Robert J. Wood, Shane Gero, David F. Gruber

Publications and Research

We implemented Machine Learning (ML) techniques to advance the study of sperm whale (Physeter macrocephalus) bioacoustics. This entailed employing Convolutional Neural Networks (CNNs) to construct an echolocation click detector designed to classify spectrograms generated from sperm whale acoustic data according to the presence or absence of a click. The click detector achieved 99.5% accuracy in classifying 650 spectrograms. The successful application of CNNs to clicks reveals the potential of future studies to train CNN-based architectures to extract finer-scale details from cetacean spectrograms. Long short-term memory and gated recurrent unit recurrent neural networks were trained to perform classification tasks, including (1) …

A Microspectra Analysis Of Synthetic Wig Fibers, Jaclyn R. Beshlian

Student Theses

The goal of this study was to determine whether differentiation between 20 visually similar light brown synthetic wig fibers was possible with the use of a microspectrophotometer (MSP). Visually similar fibers were chosen to display the power of the instrument over the human eye. An MSP is an instrument that has the ability to aid in the analysis of certain microscopical samples. With this particular instrument one is able to collect the absorption and fluorescence spectra of microscopical colored samples without destroying the piece of evidence itself. Prior to any analysis with the MSP, the material of the fibers was …

Modeling Interval Timing By Recurrent Neural Nets, Theodore Raphan, Eugene Dorokhin, Andrew R. Delamater

Publications and Research

The purpose of this study was to take a new approach in showing how the central nervous system might encode time at the supra-second level using recurrent neural nets (RNNs). This approach utilizes units with a delayed feedback, whose feedback weight determines the temporal properties of specific neurons in the network architecture. When these feedback neurons are coupled, they form a multilayered dynamical system that can be used to model temporal responses to steps of input in multidimensional systems. The timing network was implemented using separate recurrent “Go” and “NoGo” neural processing units to process an individual stimulus indicating the …

Inhibition Of Mitochondrial Permeability Transition By Deletion Of The Ant Family And Cypd, Jason Karch, Michael J. Bround, Hadi Khalil, Michelle A. Sargent, Nadina Latchman, Naohiro Terada, Pablo M. Peixoto, Jeffery D. Molkentin

Publications and Research

The mitochondrial permeability transition pore (MPTP) has resisted molecular identification. The original model of the MPTP that proposed the adenine nucleotide translocator (ANT) as the inner membrane pore-forming component was challenged when mitochondria from Ant1/2 double null mouse liver still had MPTP activity. Because mice express three Ant genes, we reinvestigated whether the ANTs comprise the MPTP. Liver mitochondria from Ant1, Ant2, and Ant4 deficient mice were highly refractory to Ca2+-induced MPTP formation, and when also given cyclosporine A (CsA), the MPTP was completely inhibited. Moreover, liver mitochondria from mice with quadruple deletion of Ant1, Ant2, Ant4, and Ppif (cyclophilin …

Histology Atlas: Basic Mammalian Tissue Types (Biol 105), Joshua Barnes, Daniel J. Yakubov, Corinna Singleman, Nathalia G. Holtzman

Open Educational Resources

This book is a guide to the basic histology lab conducted as a part of the Queens College, CUNY Biology Department Bio105 General Biology: Physiology and Cell Biology course. This course is the first half our two-part series for biology majors. The actives are designed to be conducted over a single 3-hour lab periods which focus on the relationship of form and function of the cellular and organ level anatomy and physiology. Step by step instructions for each slide set are provided for all the key organs.

In addition to the full text of the book, we also provide a …

Fetal Pig Dissection Manual (Biol 105), Nathalia G. Holtzman, Daniel J. Yakubov

Open Educational Resources

This book is a guide to the basic fetal pig dissection conducted as a part of the Queens College, CUNY Biology Department Bio105 General Biology: Physiology and Cell Biology course. This course is the first half our two-part series for biology majors. The actives are designed to be conducted over a three- 3-hour lab periods which focus on the relationship of form and function of the pig anatomy and physiology. Step by step instructions for the dissection are provided along with some microscopy tasks to look at the histology of key organs.

In addition to the full text of the …