Digital Commons Network^™

Astrocytes Deliver Ck1 To Neurons Via Extracellular Vesicles In Response To Inflammation Promoting The Translation And Amyloidogenic Processing Of App, Zhigang Li, Mohammed Moniruzzaman, Raha M. Dastgheyb, Seung-Wan Yoo, Meina Wang, Hongbo Hao, Jia Liu, Patrizia Casaccia, Carlos Nogueras-Ortiz, Dimitrios Kapogiannis, Barbara S. Slusher, Norman J. Haughey

Advanced Science Research Center

Chronic inflammation is thought to contribute to the early pathogenesis of Alzheimer’s disease (AD). However, the precise mechanism by which inflammatory cytokines promote the formation and deposition of Aβ remains unclear. Available data suggest that applications of inflammatory cytokines onto isolated neurons do not promote the formation of Aβ, suggesting an indirect mechanism of action. Based on evidence astrocyte derived extracellular vesicles (astrocyte derived EVs) regulate neuronal functions, and data that inflammatory cytokines can modify the molecular cargo of astrocyte derived EVs, we sought to determine if IL-1β promotes the formation of Aβ indirectly through …

Legislation, Linguistics, And Location: Exploring Attitudes On Unauthorized Immigration, David A. Caicedo, Vivienne Badaan

Publications and Research

Contemporary discourse on domestic immigration policy varies widely based on political affiliation, linguistics, and regional differences. This experimental study aimed to concurrently investigate three social psychological bases of attitudes towards unauthorized immigrants in the United States: political ideology, social labels, and social context. Participants were 744 adults, recruited from “New York Community College” (“NYCC”/urban) and “New Jersey Community College” (“NJCC”/suburban), who were randomly assigned to one of two experimental conditions: “illegal” vs. “undocumented”. Participants completed a scale measuring their attitudes towards unauthorized immigrants with the embedded label manipulation, followed by the General System Justification scale, and culminating with demographic items. …

Luteolin Induces Cytotoxicity In Mix Cellularity Classical Hodgkin's Lymphoma Via Caspase Activated-Cell Death, Rajendra Gharbaran, Enyuan Shang, Onyekwere Onwumere, Naomi Codrington, Evangelina Dankwa Sarpong, Stephen M. Redenti

Publications and Research

Background/aim: We investigated the effects of luteolin (LUT) on classical Hodgkin's lymphoma (cHL), since such studies in malignant lymphomas are lacking.

Materials and methods: Effect of LUT on cell growth was assessed with water-soluble tetrazolium 1 (WST-1) cell proliferation assay and automated hemocytometry on trypan blue-exclusion assay. Cell death was investigated with acridine orange/ethidium bromide live-dead assay, propidium iodide (PI) flow cytometry, and Annexin-V-PI microscopy. Caspase activation was studied using CellEvent Caspase-3/7 Green detection reagent. High resolution immunofluorescence microscopy was used to detect cleaved-PARP-1.

Results: LUT induced a dose-dependent decrease in the growth of KMH2 and L428 cells, cellular models …

The Quest For Greener Pastures: Evaluating The Livelihoods Impacts Of Providing Vegetation Condition Maps To Pastoralists In Eastern Africa, Elia Machado, Helene Purcell, Andrew M. Simons, Stephanie Swinehart

Publications and Research

The survival of millions of pastoral households in Eastern Africa has become increasingly at risk. Due to mounting socioeconomic and climatic stressors, pastoral households are faced with making migration decisions under increasing uncertainty about resource availability and limited coping strategies. We assess the potential of providing vegetation condition maps to support the migration decision of pastoralists in Ethiopia and Tanzania and the effect of map usage on their herd condition and size. The maps were generated from remotely sensed data using the Normalized Difference Vegetation Index (NDVI) as a proxy for vegetation condition and overlain with pastoralists’ preferred grazing areas. …

Sharing And Organizing Research Products As R Packages, Matti Vuorre, Matthew J. C. Crump

Publications and Research

A consensus on the importance of open data and reproducible code is emerging. How should data and code be shared to maximize the key desiderata of reproducibility, permanence, and accessibility? Research assets should be stored persistently in formats that are not software restrictive, and documented so that others can reproduce and extend the required computations. The sharing method should be easy to adopt by already busy researchers. We suggest the R package standard as a solution for creating, curating, and communicating research assets. The R package standard, with extensions discussed herein, provides a format for assets and metadata that satisfies …

Employing High Probability Gene Choice Elements To Understand Singular Odorant Receptor Expression, Raena Mina

Dissertations, Theses, and Capstone Projects

The ability to detect odorous chemicals in the environment is the oldest of the senses necessary for survival, from escaping danger, finding mates, to locating food. It is said that humans can identify and discriminate up to a trillion different odor mixtures. For chemoreception to have such a high discriminatory power, would require a diverse population of cells dedicated for odor detection. These detector cells are the olfactory sensory neurons (OSNs), which express odorant receptors (ORs) that bind to chemical odors in the environment. In order to increase specificity and sensitivity, an essential property in olfaction is for each OSN …

Investigating The Neural Mechanisms Of Unconscious And Illusory Touch Perception, Lua Koenig

Dissertations, Theses, and Capstone Projects

Despite our everyday reliance on touch, from manipulating tools to dressing ourselves, relatively little is known about the neural correlates of tactile perception. As with other modalities, our conscious, reportable experiences of touch can dissociate from the physical tactile stimulation processed by the skin. In unconscious touch perception, tactile stimuli can be processed and guide our behavior without an accompanying conscious percept. For example, we may swat away a mosquito without having consciously registered its presence on our skin. In tactile illusions, conscious tactile experiences occur without a corresponding tactile stimulus. Multisensory tactile illusions arise when stimulation of a different …

The Political Aesthetic Of Hannah Arendt: Modernity, Judgment, And Culture, Quixote R. Vassilakis

Dissertations, Theses, and Capstone Projects

The plan of this thesis is, first, to interpret Arendt’s critique of the modern age. Next, this paper outlines Arendt’s reconceptualization of Kant’s theory of judgment as the basis for a novel model of the public sphere in light of the conditions of modernity. Finally, this paper explores Arendt’s poetics as a means of activating the faculty of judgment in order to reconcile with the modern world. In order to address the political crises of modernity, Arendt develops a political aesthetic alive to the role of narrative and culture in reconstituting political communities. I argue that Hannah Arendt develops a …

Mitigating Gender Bias In Neural Machine Translation Using Counterfactual Data, Alan Wong

Dissertations, Theses, and Capstone Projects

Recent advances in deep learning have greatly improved the ability of researchers to develop effective machine translation systems. In particular, the application of modern neural architectures, such as the Transformer, has achieved state-of-the-art BLEU scores in many translation tasks. However, it has been found that even state-of-the-art neural machine translation models can suffer from certain implicit biases, such as gender bias (Lu et al., 2019). In response to this issue, researchers have proposed various potential solutions: some have proposed approaches that inject missing gender information into models, while others have attempted modifying the training data itself. We focus on mitigating …

Occitan Musicians, Immigration, And Postcolonial Regionalism In Southern France, Sarah E. Trouslard

Dissertations, Theses, and Capstone Projects

Based on ethnographic fieldwork conducted in southern France, this dissertation analyzes contemporary Occitan musical expression in relation to postcolonial immigration. “Occitan” refers to a group of linguistic practices found in the south of France, including Provençal and Languedocien. Throughout this study, I discuss commonalities between postcolonial and regionalist history and theory, shedding light on notions of cultural citizenship that have defined French sociopolitics in recent decades. The historian Herman Lebovics (2004) coined the term “postcolonial regionalism” in reference to the impact of decolonization on regional protest movements in France during the 1970s. During that time, singer/songwriters of the nòva cançon …

Mobile Cognitive Training For The Cognitive Symptoms Of Depression In Young Adults: A Double-Blind, Randomized Pilot Study With Active Control, Alice Grinberg

Dissertations, Theses, and Capstone Projects

Background: Depression is associated with a broad range of cognitive symptoms, including reduced attention, verbal learning and memory, executive functioning (EF), and processing speed (PS). Computerized cognitive training (CCT) has been shown to ameliorate the cognitive symptoms of depression. Younger adults, in particular, are understood to benefit more from CCT than older adults due to their greater capacity for neuroplasticity. However, several issues remain unclear about the effectiveness of CCT: (1) whether the benefits of CCT are driven by the specific content or by non-specific factors, such as engagement, motivation, novelty, and expectancy, which have been inadequately controlled in prior …

Ujamaa Policies And Women Gender Issues Of Land Tenure In Tanzania, Nasa S. Edgar

Dissertations, Theses, and Capstone Projects

History has shown us that women always have a part to play in society and that they have fought to receive equal opportunity with their male counterparts. In the United States in the late 1800s and early twentieth century, this movement by women became known as the women’s suffrage movement. It paved the way to women fighting for equal opportunity including for the right to vote and equal pay. In Tanzania, women fought and continue to fight against customary practices that are discriminatory against them. In this thesis I make three arguments: 1. I argue that the history of the …

Reflections On The Eating Of Bologna Sandwiches: A Memoir, Benjamin M. Raphael

Dissertations, Theses, and Capstone Projects

Reflections on the Eating of Bologna Sandwiches is a memoir project intended to give light to my experiences teaching in a small public school located in the South Bronx. These experiences are directed to a general “second” person who takes the form of “you” and is intended to act as a general stand-in for the student population of this school, similar to the “you” used by James Baldwin in his seminal work “My Dungeon Shook”. This “you” is meant to breakdown the wall between the reader and the student population, allowing one to occupy another and in the process develop …

Functions Of Fibroblast Growth Factor Homologous Factor 2 In Excitable Tissues, Christopher Marra

Dissertations, Theses, and Capstone Projects

Purpose: Fibroblast Growth Factor Homologous Factors (FHFs) are a group of proteins known to associate with and modulate voltage-gated sodium channels (Na_v) in excitable cells. The four FHF genes are differentially expressed in specific cell-types, with FHF2 expressed prominently in the hippocampus, cerebral cortex, heart and dorsal root ganglia. Due to previous unavailability of an Fhf2 knockout mouse, this gene’s functions have been understudied in comparison to other those encoding other FHFs. The purpose of this research has been to better understand the normal physiological functions of FHF2 at the cellular and system levels in the heart, sensory …

Searching For Pōhakuloa: A Citizen Scientist’S Journey In Aloha ‘Āina, Drake Logan

Dissertations, Theses, and Capstone Projects

This dissertation tells a story about the United States (US) military’s land occupation of two Indigenous Hawaiian wahi pana (sacred places), on O’ahu and Hawai’i Island, which have produced widespread health concerns regarding exposure to military toxins. I conducted six months of fieldwork in Hawai’i, in which I partnered with local communities in a Critical Participatory Action research process. Together, we formed and co-led a community-based science pilot study of contamination from Pōhakuloa Training Area, generating new citizen science methods capable of uncovering evidence on confirmed military toxics uses. These methods were developed in critical solidarity with international communities who …

360º Video And Language Documentation: Towards A Corpus Of Kanien'kéha (Mohawk), Joseph Pentangelo

Dissertations, Theses, and Capstone Projects

Robust documentation is a major goal of documentary linguistics. Recognizing spoken language as a multimodal phenomenon, researchers working in this field broadly agree that video is an improvement over audio-only recording. At the same time, video is limited by the format’s frame, which permits only a relatively small portion of the visual field to be recorded at any given time. This results in much data being lost, as the documenter must decide where to aim their camera, necessarily leaving out more than they record.

In this dissertation, I apply 360º video to language documentation for the first time. 360º video, …

The Women That No One Wanted To See: The Duality Of The Women Within The Holocaust, Valerie Cabezas-Iacono

Dissertations, Theses, and Capstone Projects

This paper is a brief historiography of the complexities of unraveling how gender constructs inform how society perceives both female perpetrators of the Third Reich and victims of sexual assault during the Holocaust. The women within these categories experienced vastly different power dynamics from 1939-1945 with the implementation of anti-Semitic ideology that would go on to forge the genocidal policies of the Nazi State. Seemingly, Aryan and Jewish women had no traits that linked them besides their biological sex, and this one factor determined how their experiences would translate within the male-centered discourse of the Holocaust. The framework of Holocaust …

Mashing Through The Conventions: Convergence Of Popular And Classical Music In The Works Of The Piano Guys, Alina Kiryayeva

Dissertations, Theses, and Capstone Projects

This dissertation is dedicated to examining the symbiosis between popular music and Western classical music in classical/popular mashups––a new style within the classical crossover genre. The research features the works of The Piano Guys, a contemporary ensemble that combines classical crossover characteristics and the techniques from modern sample-based styles to reconceptualize and reuse classical and popular works. This fusion demonstrates a new approach to presenting multi-genre works, forming a separate musical and cultural niche for this creative practice.

This dissertation consists of three chapters. The first chapter is further divided into two thematic discourses: genre and authorship. The research draws …

Neurodevelopmental Mechanisms Of Adverse Trauma Outcomes In Emerging Adulthood, Olena Kleshchova

Dissertations, Theses, and Capstone Projects

Background: Exposure to traumatic stress and adversity during the formative years of development can have adverse effects on mental health, neuroendocrine stress system function, and the brain, that persist into adulthood. One candidate mechanism that might confer vulnerability to enduring adverse outcomes of early life trauma is disruption of normal brain maturation. As the brain matures, functional interactions among brain regions change until the functional brain architecture (i.e., the functional connectome) reaches a mature state in adulthood. Given that different neural circuits have distinct developmental trajectories and sensitive periods, traumatic stress at a given point in development might have …

Intra-Familial Microaggressions, Object Relations, And Racial Identity Formation In Multiracial Individuals, Ashley Danies

Dissertations, Theses, and Capstone Projects

The concept of the self in relation to others is referred to in psychoanalytic theory as one’s ‘object-relations’ (Kernberg, 1984). One of the earliest object-relationships is between baby and caretaker(s), through which the baby develops a sense of their own identity (Mahler, 1967; Sandler & Sandler, 1978). Multiracial individuals, or those whose families fall in two or more different racial/ethnic groups, report racial microaggressions from within their own families (Nadal, Sriken, Davidoff, Wong, & McLean, 2013). Notably, Multiracial individuals who have one White parent and one non-White parent face a greater possibility of rejection from one or both sides of …

Sex/Gender Differences In Serial Position Profiles In Patients With Mild Cognitive Impairment And Healthy Controls, Emnet Z. Gammada

Dissertations, Theses, and Capstone Projects

Introduction: Alzheimer’s disease disproportionately affects more women, but paradoxically, men have a higher incidence of Mild Cognitive Impairment (MCI). Researchers have suggested that women’s verbal memory advantage across the lifespan reflects better premorbid skills, which then require more neurodegeneration to manifest early clinical impairment. To date, measurement of sex differences in verbal memory have used total list scores. We proposed that a granular examination of serial position effects (SPE) in list-learning can refine the source of sex/gender differences.

Methods: A cross-sectional analysis of participants with Mild Cognitive Impairment (MCI) and Healthy Controls (HC) was examined from the Alzheimer’s Disease Neuroimaging …

Translanguaging About, With, And Through Code And Computing: Emergent Bi/Multilingual Middle Schoolers Forging Computational Literacies, Sara Vogel

Dissertations, Theses, and Capstone Projects

As computing pervades more aspects of life, and as Computer Science for All (CS for All) initiatives roll out across the U.S., the field must understand the experiences and language practices of emergent bi/multilingual K-12 students and use that knowledge to drive equitable pedagogical and programmatic approaches. But little is known about how emergent bi/multilingual students — a growing population that school systems have often viewed with deficit-based lenses and have thus struggled to educate equitably — use language in the context of CS education. This dissertation addresses this gap by (1) qualitatively documenting and using asset-based frames to analyze …

Describing The Dress Of Women: Author’S Notes On The Development Of Gender, Cassandra B. Tan

Dissertations, Theses, and Capstone Projects

This thesis is an examination of how authors of the late Victorian and early Twentieth Century describe the embodied and mental effects of the nature of women’s clothing through works of fiction and nonfiction. Through this analysis, I argue that clothing serves as a mechanism to oppress women by eliminating concrete and philosophical access to wealth and necessities as well as by instigating acts of violence upon a developing body through stricture and hygiene. I examine the ways that feminine dress, from youth through adulthood, shapes the way women view themselves, and in turn has a reciprocal effect on how …

Tones In Shupamem Reduplication, Magdalena Markowska

Dissertations, Theses, and Capstone Projects

This thesis presents an analysis of reduplication in Shupamem, an Eastern Grassfields Bantu language of Cameroon. In this language nouns, verbs, and adjectives undergo full segmental reduplication. At the suprasegmental level, on the other hand, tones of the reduplicants are not entirely faithful to their bases. The tonal asymmetry of the reduplicted phrase also relies on the grammatical function of that phrase within a clause, as well as on the neighboring grammatical words, such as tense particles. This morphological process gives also an insight to an underlying tonal representations in Shupamem. Nominal reduplication, in particular, provides a proof of the …

Inspirations For Awake: Expressions Of Trauma Through Fiction And Autoethnographic Literature, Sophia Rodriguez

Dissertations, Theses, and Capstone Projects

Awake is a novella based on true events in my own life. This capstone project addresses my own experiences with intimate partner violence. While it is inspired by my life, I chose to write a fictional narrative rather than a strictly biographical piece of nonfiction. Instead, this novella illustrates a few of the traumas that I went through from within the lens of a fictional narrative. This enabled me to tell about my experiences by crafting my memories into a story, without the pressure of submitting an accounting of them. Writing Awake has been helpful to me in that it …

Misuse Of Social Behavior In Down Syndrome: Caregiver Conducted Functional Analysis, Sally M. Izquierdo

Dissertations, Theses, and Capstone Projects

Young children with Down syndrome often engage in charming non-contextual social behaviors. The developmental literature suggests that non-contextual social behaviors may function to escape from difficult activities to preferred social interactions. Caregivers may reinforce the behavior, perceiving it as evidence of the child’s social strength, when in fact, the pattern of behavior may also contribute to missed learning opportunities and a developmental gap between children with Down syndrome and their typically developing peers. We investigated the pattern by subjecting it for the first time to functional analyses. We identified non-contextual social behavior, confirmed function(s) of escape to attention, and compared …

Memory For Episodic Details Of Naturalistic Events Remains Stable Over The Course Of One Week, Kennedy E. Stomberg

Dissertations, Theses, and Capstone Projects

We have many experiences every day, and we tend to parse them into individual events. While many studies have been conducted to understand the nature of event segmentation, less is known how event memories change over time. In the present study, participants watched a movie clip, and then were asked to immediately retell what they had seen. They performed the same free recall task a week later. We found that the passage of time did not significantly affect the number of recalled events or the detailedness of event memories. We discuss potential explanations for our findings, including our small sample …

Emotion In Mind, Kathryn E. Pendoley

Dissertations, Theses, and Capstone Projects

Emotions consume our thoughts and drive our actions. If you had different emotions, or no emotions at all, the way you move in the world and understand your place in it would be completely different. We need a satisfactory theory of emotion for a complete science of the mind. In this dissertation, I consider two of the most compelling theories of emotion: broad perceptualism – the view that emotions either are themselves perceptual or include a perceptual aspect as at least a part – and constructionism – the theory that emotions are self-interpretive thoughts. I find that perceptualist thinking fails …

Eating The Heart Of Weetigo World: Decolonial Imaginaries In The Stories Of Louise Erdrich And Tomson Highway, Rebecca Lynne Fullan

Dissertations, Theses, and Capstone Projects

My dissertation asks what the decolonial possibilities of fiction are in the context of the settler colonial imaginaries particular to the United States and Canada. The ongoing process of settler colonialism demands various forms of conversion from Indigenous people: ecological/land based, religious, educational, legal, familial, but the construct of “conversion” obscures Indigenous worldviews, and indeed worlds, which function according to different principles. I interpret Erdrich and Highway's work in the context of Anishinaabe and Cree narratives and story-structures. These offer examples of what can constitute broader decolonial imaginaries, through which perception and creation of other, more liveable worlds is possible. …

Beast-Gods, Bandits, And Beggar-Kings: The Traveler In Political Thought, Nader Sadre

Dissertations, Theses, and Capstone Projects

In this dissertation, I use texts by Plato, Locke, Homer, and Gandhi to explore the political dimension of travel. I argue that travel is a proxy for practices and conditions that exceed “normal” politics. In this capacity, travel reveals what normal politics is, or is assumed to be. Travel marks a boundary of the political realm in a double sense: it may conceal or point to a pre-political source of authority; and it may provide an intimation of new political modes and orders. My analyses suggest that there is no single or consistent relationship between travel and politics. Rather, the …