Digital Commons Network^™

Investigation Of Behavioral Responses Including Visual Side Biases To Social Stimuli In Bottlenose Dolphins (Tursiops Truncatus), Jennifer R. Savoie

Dissertations, Theses, and Capstone Projects

Cetacean field studies have reported consistent population-level side biases for foraging behaviors and this right side feeding bias is arguably the strongest in any species next to handedness in humans. Notably, experimental studies with cetaceans, particularly dolphins, have struggled to find laterality in other behaviors, and some have reported patterns that are inconsistent with those typically found in vertebrates. Side biases related to social processing have been reported in a few observational studies of wild delphinids but have not been successfully evaluated in a controlled experimental context. This dissertation investigated viewing side biases of bottlenose dolphins in two contexts: when …

Go Off: The Geography And Labor Of Off- And Off-Off-Broadway, Sean C. Mellott

Dissertations, Theses, and Capstone Projects

Off- and Off-Off-Broadway remain ill-defined and misunderstood sectors of New York City’s theatre industry, at least when compared with Broadway. This capstone project examines these dual sociocultural spaces and defines some of their contours through a primary analytical lens of geography (the physical locations where Off- and Off-Off-Broadway are produced) and a secondary lens of labor (the professional contexts in which Off- and Off-Off-Broadway are produced). Both elements speak to the material conditions of theatrical production in New York City, offering clues as to Off- and Off-Off-Broadway’s position within the entertainment industry and their relationship to the larger social structure …

Janus V. Afscme, Revisited, Benjamin Derek Morse

Dissertations, Theses, and Capstone Projects

In the days after the Supreme Court handed down its ruling in Janus v. AFSCME (2018)—a 5-4 conservative majority decision deeming the imposition of public union agency fees unconstitutional under the First Amendment—observers declared the end of public-sector unions. The Times called the ruling a “Sharp Blow ''[1] to organized labor. A Washington Post headline deemed the decision a “major blow”[1] [2] In the former piece, the Time’s Supreme Court correspondent wrote that “most of the labor movement’s strength these days is in the public sector. The [Janus] ruling contained a final blow for public …

Peru's Fishmeal Industry: Its Societal And Environmental Impact, Angel Vizurraga

Dissertations, Theses, and Capstone Projects

Peru is the biggest fishmeal-producing country in the world. It has exported millions of tons of fishmeal to various parts of the world since the 1960s. However, this industry has created many problems for the Peruvian people and their environment. Past research done on this topic has failed to include the negative impacts of the fishmeal industry. My project aims to exhibit the main issues that are affected or created by the fishmeal industry. I will talk about its impact on socioeconomic matters such as malnutrition and employment, as well as its impact on the environment and the wildlife population …

Girl Friends, Camila Santander

Dissertations, Theses, and Capstone Projects

Friendships between women are common and essential parts of women's lives; however, they are often overlooked. This capstone project titled Girl Friends is a film on which eight women are interviewed and asked about their friendships with other women. They discuss the importance of having female friends and how they create love, support, and companionship. The interviewees also talk about female friendships and romantic partners coexisting, the pressures to find a romantic partner to find fulfillment, as opposed to good friends. Additionally, they describe how friendships between women can be competitive and catty, and how female relationships can change as …

Conservation, Comparative Genomics And Species Delimitation Of The Reindeer Lichens (Cladonia), Jordan R. Hoffman

Dissertations, Theses, and Capstone Projects

The genus Cladonia represents one of the most speciose genera of lichenized fungi, with more than 500 known species encompassing a diverse array of morphologies and habits. These lichens form keystone species in many habitats, serving a variety of ecological roles. However, despite being among of the more well studied lichens, there is much still unknown or under-studied about them. As is the case with most lichen study systems, phylogenetic study has been limited to a small number of partial loci, while adoption of next-generation sequence methods has been slow. As a consequence, there are still knowledge gaps in Cladonia …

Paddling Along The Voltage Gated Sodium Channel Galaxy With Sea Anemone Toxins: Structural Studies Of The Interaction Between The Paddle Motif From Nav1.5div And Sea Anemone Toxin, Adel K. Hussein

Dissertations, Theses, and Capstone Projects

Voltage gated sodium channels (VGSC) are membrane proteins that serve an important function in the central nervous system (CNS), peripheral nervous system (PNS), and cardiac muscles amongst others. The main function of VGSC is in the propagation of electrical signals by depolarizing excitable cells. Nine mammalian VGSC subtypes have been characterized, Na_V1.1 – Na_V1.9, that are expressed in a tissue specific manner, each with unique gating properties. Numerous diseases have been linked to defects in VGSC including epilepsy, mental retardation, long QT syndrome, and Brugada disease. Furthermore, these channels are one of the primary targets of …

Novel Strategies For Glutamate Clearance In The Glia-Deprived Synaptic Hub Of C. Elegans, Joyce Chan

Dissertations, Theses, and Capstone Projects

As the major excitatory neurotransmitter in the mammalian brain, Glutamate (Glu) is critical for normal neuronal physiology. Disruption in Glu clearance results in hyper-stimulation of glutamatergic circuits, potentially leading to excitotoxic neurodegeneration. The canonical model of brain connectivity describes glutamatergic synapses as well insulated and enveloped by glia. These glia express Glu Transporters (GluTs) which work to clear Glu following synaptic activity. However, critical areas of the brain such as the mammalian hippocampus display poor synaptic isolation, which may result in Glu spillover between adjacent synapses and subsequent loss of circuit specificity. How accurate signal transmission is achieved in these …

My Favorite Thing Is Monster Theory: Horror Comics And Demonstrating Difference In Emil Ferris’S "My Favorite Thing Is Monsters", Jennifer Rossberg

Dissertations, Theses, and Capstone Projects

My Favorite Thing is Monsters (2017) by Emil Ferris opens with the same etymological analysis of the word monster as Rosemarie Garland Thomson’s landmark disability studies article, “From Wonder to Error: A Discourse on Freak Genealogy” (1991). The protagonist of Ferris’s swirling, sketchbook-style thriller, Karen Reyes, is a mixed-race queer adolescent growing up in noirish 1960’s Chicago who longs to be a werewolf so she can bite and save her cancer-afflicted mother. After fleeing an imaginary, pitchfork-wielding M.O.B.—an acronym for “mean, ordinary, & boring” people—Karen explains that, “The dictionary says the word monster comes from the Latin word ‘monstrum’ which …

Reducing Fear Overgeneralization With Safety Learning: Attention Bias As A Moderator, Boyang Fan

Dissertations, Theses, and Capstone Projects

Anxiety disorders are the most prevalent mental health condition and affect one out of nine individuals around the world. Fear generalization is a neurocognitive mechanism thought to maintain and exacerbate anxiety, and thus is an important target of therapeutic interventions. Yet, intervention research and practice place relatively little emphasis on its importance. Given that a significant proportion of individuals do not respond to extant treatments of anxiety disorders, a strengthened focus on fear generalization may inform the development and personalization of new treatment approaches. Recent notions have linked fear generalization to failures in distinguishing between signals that predict the occurrence …

Molecular Mechanisms Of Microrna-1205 In Aggressive Prostate Cancer, Michelle K. Naidoo

Dissertations, Theses, and Capstone Projects

Prostate cancer (PCa) is one of the most commonly diagnosed cancers among men in the United States. High mortality rates of PCa are associated with metastatic castration-resistant prostate cancer (mCRPC) due to the maintenance of androgen receptor (AR) signaling despite androgen deprivation therapies (ADTs). Resistance to second generation ADTs leads to the progression of AR-independent treatment related-neuroendocrine PCa (t-NEPC), which is observed in nearly 1 in 5 men with mCRPC and is associated with very poor outcomes. The 8q24 chromosomal locus is a region of very high PCa susceptibility that carries genetic variants associated with PCa aggressiveness. Located at this …

A History Of The Center For The Study Of Women And Society, 1975–2015, Clarisa Gonzalez

Dissertations, Theses, and Capstone Projects

In the early 1970s, New York City was experiencing an extreme fiscal crisis, with a reported debt of at least $600 million. In CUNY, students were protesting admissions policies that favored the white middle class and hikes in tuition. At the same time, the women’s movement was in the midst of the “second wave,” focusing on women in the workplace and in education. It’s in the midst of these tumultuous times that the first motions to create what was then called the Center for the Study of Women and Sex Roles began in 1975 by Graduate Center faculty Joan Kelly, …

A Girl Is A Thing: Dramaturgies Of Objects And Nature In Contemporary Choreography, Fidan Akinci

Dissertations, Theses, and Capstone Projects

This dissertation investigates the expansion of performative possibilities toward and through nonhumans in contemporary choreography as a feminist inquiry. I research the upsurge of performing objects and natural matter in contemporary choreography by questioning what kind of bodies other than humans can move, and what kind of affects and expressions they offer beyond more familiar and anthropocentric possibilities. I link this challenge to the humanistic limits of performance with the feminist interrogations on agency and objectification to fully explore the political stakes of mobilizing with the nonhuman. To that end, I put the feminist trajectories in posthumanism, new materialism, and …

Air Pollution, Climate Change, And Our Health, Kathia Vargas Feliz

Dissertations, Theses, and Capstone Projects

Climate change is a subject that is creating a lot of controversies nowadays. From newspapers to researchers, there are big efforts going on trying to bring awareness about the effects of air pollution and climate change over time. It is recommended that governments all over the world, and people from all communities act by taking care of the environment because the situation might turn out to be irremediable. There is a quote by Leonardo Dicaprio stating, “Climate change is real. It is happening right now; it is the most urgent threat facing our entire species and we need to …

Mapping Flood Myths, Ashley Marie Rojas

Dissertations, Theses, and Capstone Projects

Water, as the source of all life, has the power to create and destroy. Floods, prior to modern meteorology, would have been seen as acts of the divine, leading to the creation of flood myths, stories, and legends from many civilizations. The power of water transcends time and connects all of humankind. Present day examples including hurricanes here in the US (Katrina, Maria, Irene to just name a few) and tsunamis like at Fukushima. Mapping Flood Myths will look at flood myths and legends from all over the world and plot the locations of these myths on web map with …

Alternative Food Production In Cauca, Colombia: The Value Of Agroecological Food Systems For Local Small Producers And Consumers, Andrea Negret

Dissertations, Theses, and Capstone Projects

This thesis intends to offer an integral view of the reality of food production and distribution in the Cauca Department in Colombia, observing the different practices that have caused deep social and environmental struggles including systemic violence, displacement and environmental degradation. The first two chapters will offer a global and national context of food production to better understand the many challenges that rural populations endure in rural Cauca. Chapters four and five will explore some resistance strategies and movements that rural communities in Cauca and other Colombian regions have developed to fight against corporate agro-industrial dominance so they can protect …

Essays In Development Macroeconomics, Miguel Orozco Vazquez

Dissertations, Theses, and Capstone Projects

This dissertation consists of three chapters that cover topics on development macroeconomics.

Chapter 1 - Misallocation of Resources and Total Factor Productivity: Evidence from Mexico. This paper aims to measure the gross output loss due to misallocation of resources in the manufacturing and service sectors in Mexico during 2008-2018 and identify the inputs of production related to it. To do so, I use Mexican Economic Censuses and an extension of Hsieh and Klenow (2009). I also include resource misallocation computations using data processed with a Bayesian model for editing and imputing data to correct for measurement error (MEC data), which …

Narcommunication: The Messaging, Marketing, And Murder Of Organized Crime, Philip L. Johnson

Dissertations, Theses, and Capstone Projects

Criminal actors are widely assumed to maintain a low profile, exerting power through corruption, coercion, and clandestine networks. Scholarship that addresses public action on the part of criminal actors focuses almost exclusively on acts of violence. However, an ample empirical record demonstrates that criminal actors also communicate publicly to broad audiences. To better understand this practice, this project focuses on the phenomenon of narco-messaging in Mexico. The project asks: what do criminal actors say when they speak publicly, and why do they say it?

The core data for this project comes from an original collection of 6,178 narco-messages that appeared …

"It Was Handed To Them": The Origins Of Targeted Delivery And The Spirit Of Nanomedicine, Marzena Woinska

Dissertations, Theses, and Capstone Projects

Nanotechnology is widely recognized as an important field. Since the 2000s, nano-based targeting has been a cutting-edge approach in cancer research. To specify what nanomedicine means and describe its significance at the cultural level, this study harnesses data from peer-reviewed articles published in leading scientific journals.

Balancing precariously between sociological theory and science and technology studies, this project turns to nanomedicine’s origins to address broader questions regarding the relationship between science and society and the causes of scientific discovery and technological innovation. It tells the story of nanotechnology's discursive formations taking on a life of their own and congealing into …

Historical Sisters: Black Feminist Actions Across History And Literary Studies, Jazz A. Milligan

Dissertations, Theses, and Capstone Projects

This thesis seeks to understand how the actions of Black women from the past have inspired the modern Black female literary movement. This thesis focuses on three historical women: Phillis Wheatley, Elizabeth Freeman, and Cathay Williams, and their literary sisters: bell hooks, Barbara Smith, and Patricia Hill Collins. By viewing the lives of these historical women through a modern-day lens, we can understand how their actions created a ripple effect that Black women are still discussing today. Black feminism did not start in a vacuum, and the actions of everyday Black women have pushed us forward to being more accepting …

Histone Post-Translational Modification Dysregulation Contributes To Toxicity In Amyotrophic Lateral Sclerosis Proteinopathy Models, Seth A. Bennett

Dissertations, Theses, and Capstone Projects

Amyotrophic Lateral Sclerosis (ALS) is the third most common adult onset neurodegenerative disorder worldwide. It is generally characterized by progressive paralysis starting at the limbs ultimately leading to death caused by respiratory failure. There is no cure and current treatments fail to slow the progression of the disease. As such, new treatment options are desperately needed. Epigenetic targets are an attractive possibility because they are reversible. Epigenetics refers to heritable changes in gene expression unrelated to changes in DNA sequence. Histone modifications, a main epigenetic mechanism, occur in many amino acid residues and include phosphorylation, acetylation, methylation as well as …

Control, Allegiance, And Shame In Male Qing Dynasty Hairstyles, Carolle Pinkerton

Dissertations, Theses, and Capstone Projects

This thesis is about the politicization of hairstyles in imperial China. They indicated conformity with social norms, or rebellion against them. This was especially true under the country’s last dynasty. The Manchu conquerors imposed their own hairstyle, the queue, on their Han Chinese subjects to make their rule palpable to China’s illiterate millions. “Hair martyrs” who refused to accept this “barbarous” hairstyle were ruthlessly eliminated. The Manchus had feared assimilation into the much larger Han population. But the introduction of one uniform male hair style for both Manchus and Han blurred the lines between the two groups. In this way …

Past-Futures Of Harlem: Black Urban Space At The Limits Of Spatial Justice, Dane C. Ruffin

Dissertations, Theses, and Capstone Projects

The racial capitalist development of the U.S. metropolitan landscape has been shaped by the involuntary displacement and dispersal of Black communities. From the dispossession of the Half-Free Negro Lots around the Fresh Collect pond in the seventeenth century to the clearing of Seneca Village to build Central Park in the nineteenth century to the turn of the twentieth-century police-facilitated “race riot” in the Tenderloin district of Manhattan, which fueled the move to Harlem, the four-hundred year history of Black Manhattan alone provides substantial evidence of this and is in no way unique in this regard. Incomplete, yet ongoing, is what …

Maternal Choline Supplementation And High-Fat Feeding Interact To Influence Dna Methylation In Offspring In A Time-Specific Manner, Hunter W. Korsmo, Bhoomi Dave, Steven E. Trasino, Anjana Saxena, Jia Liu, Jorge Matias Caviglia, Kaydine Edwards, Moshe Dembitzer, Shameera Sheeraz, Sarah Khaldi, Xinyin Jiang

Advanced Science Research Center

Maternal methyl donor supplementation during pregnancy has demonstrated lasting influence on offspring DNA methylation. However, it is unknown whether an adverse postnatal environment, such as high-fat (HF) feeding, overrides the influence of prenatal methyl donor supplementation on offspring epigenome. In this study, we examined whether maternal supplementation of choline (CS), a methyl donor, interacts with prenatal and postnatal HF feeding to alter global and site-specific DNA methylation in offspring. We fed wild-type C57BL/6J mouse dams a HF diet with or without CS throughout gestation. After weaning, the offspring were exposed to HF feeding for 6 weeks resembling a continued obesogenic …

Does Breastfeeding Account For The Association Between Maternal Sensitivity And Infant Cognitive Development In A Large, Nationally Representative Cohort?, P. Nina Banerjee, Karen E. Mcfadden, Jacqueline D. Shannon, Leslie L. Davidson

Publications and Research

Background: Previous research has established that exposure to high maternal sensitivity is positively associated with advances in infant cognitive development. However, there are many fixed and modifiable factors that influence this association. This study investigates whether the association between maternal sensitivity and infant cognitive development in the first year of life is accounted for by other factors, such as breastfeeding, maternal depressive symptoms, maternal alcohol use, infant birth weight or demographic covariates.

Methods: Using data from the Early Childhood Longitudinal Study-Birth (ECLS-B) Cohort, a nationally representative sample of U.S. born children, multi-variable regression analyses was used to examine whether breastfeeding, …

Results Of A Phase 1, Randomized, Placebocontrolled First-In-Human Trial Of Griffithsin Formulated In A Carrageenan Vaginal Gel, Natalia Teleshova, Maria J. Keller, José A. Fernández Romero, Barbara A. Friedland, George W. Creasy, Marlena G. Plagianos, Laurie Ray, Patrick Barnable, Larisa Kizima, Aixa Rodriguez, Nadjet Cornejal, Claudia Melo, Gearoff Cruz Rodriguez, Sampurna Mukhopadhyay, Giulia Calenda, Shweta U. Sinkar, Thierry Bonnaire, Asa Wesenberg, Shimin Zhang, Kyle Kleinbeck, Kenneth Palmer, Mohcine Alami, Barry R. O'Keefe, Patrick Gillevet, Hong Hur, Yupu Liang, Gabriela Santone, Raina N. Fichorova, Tamara Kalir, Thomas M. Zydowsky

Publications and Research

HIV pre-exposure prophylaxis (PrEP) is dominated by clinical therapeutic antiretroviral (ARV) drugs. Griffithsin (GRFT) is a non-ARV lectin with potent anti-HIV activity. GRFT’s preclinical safety, lack of systemic absorption after vaginal administration in animal studies, and lack of cross-resistance with existing ARV drugs prompted its development for topical HIV PrEP. We investigated safety, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of PC-6500 (0.1% GRFT in a carrageenan (CG) gel) in healthy women after vaginal administration. This randomized, placebo-controlled, parallel group, double-blind first-in-human phase 1 study enrolled healthy, HIV-negative, non-pregnant women aged 24–45 years. In the open label period, all participants (n …

The Rise And Fall Of Dopamine: A Two-Stage Model Of The Development And Entrenchment Of Anorexia Nervosa, Jeff A. Beeler, Nesha S. Burghardt

Publications and Research

Dopamine has long been implicated as a critical neural substrate mediating anorexia nervosa (AN). Despite nearly 50 years of research, the putative direction of change in dopamine function remains unclear and no consensus on the mechanistic role of dopamine in AN has been achieved. We hypothesize two stages i n AN– corresponding to initial development and entrenchment– characterized by opposite changes in dopamine. First, caloric restriction, particularly when combined with exercise, triggers an escalating spiral of increasing dopamine that facilitates the behavioral plasticity necessary to establish and reinforce weight-loss behaviors. Second, chronic self-starvation reverses this escalation to reduce or impair …

Introduction To Epigenetics, Yevgeniy Grigoryev

Open Educational Resources

Syllabus for Bio481 Introduction to Epigenetics

Transcranial Direct Current Stimulation On Parkinson’S Disease: Systematic Review And Meta-Analysis, Paloma Cristina Alves De Oliveira, Thiago Anderson Brito De Araújo, Daniel Gomes Da Silva Machado, Abner Cardoso Rodrigues, Marom Bikson, Suellen Marinho Andrade, Alexandre Hideki Okano, Hougelle Simplicio, Rodrigo Pegado, Edgard Morya

Publications and Research

Background: Clinical impact of transcranial direct current stimulation (tDCS) alone for Parkinson’s disease (PD) is still a challenge. Thus, there is a need to synthesize available results, analyze methodologically and statistically, and provide evidence to guide tDCS in PD.

Objective: Investigate isolated tDCS effect in different brain areas and number of stimulated targets on PD motor symptoms.

Methods: A systematic review was carried out up to February 2021, in databases: Cochrane Library, EMBASE, PubMed/MEDLINE, Scopus, and Web of science. Full text articles evaluating effect of active tDCS (anodic or cathodic) vs. sham or control on motor symptoms of PD were …

Glycocalyx Mechanotransduction Mechanisms Are Involved In Renal Cancer Metastasis, Heriberto Moran, Limary M. Cancel, Peigen Huang, Sylvie Roberge, Tuoye Xu, John M. Tarbell, Lance L. Munn

Publications and Research

Mammalian cells, including cancer cells, are covered by a surface layer containing cell bound proteoglycans, glycoproteins, associated glycosaminoglycans and bound proteins that is commonly referred to as the glycocalyx. Solid tumors also have a dynamic fluid microenvironment with elevated interstitial flow. In the present work we further investigate the hypothesis that interstitial flow is sensed by the tumor glycocalyx leading to activation of cell motility and metastasis. Using a highly metastatic renal carcinoma cell line (SN12L1) and its low metastatic counterpart (SN12C) we demonstrate in vitro that the small molecule Suberoylanilide Hydroxamic Acid (SAHA) inhibits the heparan sulfate synthesis enzyme …