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Consociational Democracy In Post-War Lebanon: Maintain-Ing Negative Peace And Stability Amidst Sectarian Divisions, Kasidech Somboonkittichai Jan 2023

Consociational Democracy In Post-War Lebanon: Maintain-Ing Negative Peace And Stability Amidst Sectarian Divisions, Kasidech Somboonkittichai

Asian Review

Is consociational democracy the only viable solution for maintaining direct negative peace and stability in contemporary Lebanon? This paper argues in favour of consociational democracy as the most effective approach to preserving direct negative peace and stability in post-war Lebanon. The rationale behind this claim stems from the impracticality and unsuitability of alternative solutions, particularly transformative liberal approaches, within Lebanon's specific context. Implementing such alternatives would jeopardise cooperation among elites representing different sectarian groups, leading to a perilous power vacuum and the potential for civil war reoccurrence. To contribute to the academic discourse, this paper systematically examines Lebanon's post-war regime …

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A Framework For Assessing Environmental Incidents In Coastal Areas: A Case Study In The Southeastern Coastal Area Of Vietnam, Cuong Le Tan, Phuoc Nguyen Van, Quan Nguyen Hong, Loan Tran Thi Diem, Minh Tran Thanh Jan 2023

A Framework For Assessing Environmental Incidents In Coastal Areas: A Case Study In The Southeastern Coastal Area Of Vietnam, Cuong Le Tan, Phuoc Nguyen Van, Quan Nguyen Hong, Loan Tran Thi Diem, Minh Tran Thanh

Applied Environmental Research

As developing dynamic regions, coastal areas have a high potential for environmental incidents, especially chemical spills, which may permanently threaten livelihoods and coastal ecosystems. Establishing an appropriate methodological framework for assessing environmental incidents in coastal areas, ensuring increased predictability and minimising potential consequences is a trend of interest to scientists. In this study, the environmental risk assessment model was applied to develop a framework for assessing environmental incidents in coastal areas due to chemical spills from the mainland based on hazard, exposure and vulnerability factors (i.e., sensitivity and adaptability). Using the multiple criteria decision-making (MCDM) method approach, suitable criteria, their …

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Life Cycle Assessment Of Plastic Resin: A Case Study Of The Petrochemical Industry In Thailand For The Production Of Hdpe Resin, Natthapong Wichaiutcha, Abhishek Dutta, Orathai Chavalparit Jan 2023

Life Cycle Assessment Of Plastic Resin: A Case Study Of The Petrochemical Industry In Thailand For The Production Of Hdpe Resin, Natthapong Wichaiutcha, Abhishek Dutta, Orathai Chavalparit

Applied Environmental Research

Life cycle sustainability is an important tool for assessing product performance based on the three pillars of environment, economy and society. This study examined the life cycle impact, cost and social implications of high-density polyethylene (HDPE) resin. Environmental assessment revealed nonrenewable energy as the greatest impact followed by carcinogens, respiratory inorganics and global warming while economically, the operational cost of HDPE resin production was significantly highest. The social impact assessment following the United Nation Environmental Programme (UNEP)/ Society of Environmental Toxicology and Chemistry (SETAC) guidelines demonstrated optimal performance for all indicators except for gender ratio and disabled employee criteria which …

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Optimization Of Vanillin Production From Lignin Using Catalytic Depolymerization Over A Cuo/Al2o3 Catalyst, Sirawit Sangnak, Arthit Neramittagapong, Sutasinee Neramittagapong, Somnuk Theerakulpisut, Pongsert Sriprom Jan 2023

Optimization Of Vanillin Production From Lignin Using Catalytic Depolymerization Over A Cuo/Al2o3 Catalyst, Sirawit Sangnak, Arthit Neramittagapong, Sutasinee Neramittagapong, Somnuk Theerakulpisut, Pongsert Sriprom

Applied Environmental Research

The optimal conditions for vanillin production from lignin depolymerization using CuO/Al2O3 catalysts were determined by combining Box-Behnken design (BBD) and response surface methodology (RSM). Independent variables, including temperature (80–140 °C), NaOH loading (0.5–1.5 g), time (30–90 min), and catalyst weight (0.5–1.5 g), were investigated to determine the optimal conditions, with the concentration of vanillin being the dependent variable. A CuO/Al2O3 catalyst was prepared by impregnation method. The vanillin obtained from the reaction was analyzed using high-performance liquid chromatography (HPLC). The maximum obtained vanillin concentration of 59.14 mg·L-1 was achieved with a temperature of 80 °C, a reaction time of 90 …

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Utilizing Wasteaware Benchmark Indicators To Improve Municipal Solid Waste Management In Northern Thailand, Sujitra Vassanadumrongdee, Ridthipat Kallayanapattharasit, Arisara Lekkham, Pattayaporn Unroj Jan 2023

Utilizing Wasteaware Benchmark Indicators To Improve Municipal Solid Waste Management In Northern Thailand, Sujitra Vassanadumrongdee, Ridthipat Kallayanapattharasit, Arisara Lekkham, Pattayaporn Unroj

Applied Environmental Research

Primarily responsible for waste collection and disposal, local governments in northern Thailand face significant obstacles in managing waste. Mixing infectious, hazardous and general waste, over-utilizing incinerators and implementing environmentally improper disposal methods all contribute to burgeoning volumes of waste with adverse environmental and health impacts. The objectives of this study are to use the Wasteaware benchmark indicators (WABIs) to assess the effectiveness and sustainability of the waste management of Wiengthoeng Sub-district Municipality (WSM), to identify advantages and disadvantages of its system and offer fact-based recommendations for improvement. Pertinent data was obtained through interviews of governmental authorities, community members and private …

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Estimation Of Respiratory Disease Burden Attributed To Particulate Matter From Biomass Burning In Northern Thailand Using 1-Km Resolution Maiac-Aod, Anuttara Hongthong, Kampol Nanthapong, Thongchai Kanabkaew Jan 2023

Estimation Of Respiratory Disease Burden Attributed To Particulate Matter From Biomass Burning In Northern Thailand Using 1-Km Resolution Maiac-Aod, Anuttara Hongthong, Kampol Nanthapong, Thongchai Kanabkaew

Applied Environmental Research

The upper northern Thailand suffers from air pollution due to open burning, which has been known for a long time. It was also found that different respiratory diseases were attributed to air pollution, especially particulate matter. This study estimated the health impacts attributed to PM10 between 2014 and 2016 using the burden of disease in terms of the disability adjusted life year (DALYs). The spatial correlation was evaluated based on applicable remote sensing data using the geographically weighted regression (GWR) model. The average measured PM10 concentrations for the summer and annual periods between 2014 and 2016 were 73 and 89 …

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Microplastic Contamination In The Coastal Environment: A Case Study From The Mae Klong River, Samut Songkhram, Pattraporn Chaisanguansuk, Suphak Ploenbuppa, Thitiphan Assawincharoenkij, Sumet Phantuwongraj, Akkaneewut Jiraphinyakul Jan 2023

Microplastic Contamination In The Coastal Environment: A Case Study From The Mae Klong River, Samut Songkhram, Pattraporn Chaisanguansuk, Suphak Ploenbuppa, Thitiphan Assawincharoenkij, Sumet Phantuwongraj, Akkaneewut Jiraphinyakul

Applied Environmental Research

To investigate the microplastic contamination in the coastal area in Samut Songkhram, we collected sediment samples from six locations in mangrove forests along the Mae Klong River estuary (MK) and the nearby Khlong Khon canal (KK). The microplastics were extracted by ZnCl2 density separation and subsequently H2O2 digestion. The microplastic abundance and physical properties, including their size, color, and shape, were determined under the binocular microscope. The selected microplastic samples were analyzed by µ-FTIR spectroscopy to identify their polymer types. Microplastic concentrations were c. 580 and 1690 items kg-1 d.w. in the samples from MK and KK. The lower microplastic …

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Groundwater Potential Mapping At Highly Populated Sub-Districts Of Thimphu District Using Fuzzy Analytic Hierarchy Process, Thongley Thongley, Tshering Choki, Kuenzang Choden Jan 2023

Groundwater Potential Mapping At Highly Populated Sub-Districts Of Thimphu District Using Fuzzy Analytic Hierarchy Process, Thongley Thongley, Tshering Choki, Kuenzang Choden

Applied Environmental Research

Groundwater is important when there is an insufficient spring water supply for daily needs. The population growth and expansion of the cities demand more water. Thimphu is the capital city of Bhutan and facing water shortage in recent times due to urban expansion and population growth. This study aims to find the potential area for groundwater using the Fuzzy Analytic Hierarchy Process. The factors used for this study are elevation, slope, curvature, topographic wetness index, drainage density, normalized difference vegetation index, distance from fault density, rainfall distribution map, soil texture map, and drainage density. The rating for the factors and …

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Assessment Of Heavy Metal Cd And Pb Concentrations And The Ecological Risk From Seawater, Sediments, And Perna Viridis In Semarang Bay, Indonesia, Max Rudolf Muskananfola, Agus Hartoko, Nurul Latifah Jan 2023

Assessment Of Heavy Metal Cd And Pb Concentrations And The Ecological Risk From Seawater, Sediments, And Perna Viridis In Semarang Bay, Indonesia, Max Rudolf Muskananfola, Agus Hartoko, Nurul Latifah

Applied Environmental Research

Semarang Bay is a multiple water source from some rivers located at the forefront of the most populated city in Central Java. These waters are polluted by wastes from various sources. Previous studies conducted were limited to specific areas and were mainly focused on one or two media only. This research aims to analyse the heavy metal Cd and Pb concentrations in seawater, sediments, and green mussels and the ecological risks. Field data were collected from 18 sites from three locations: Semarang, Demak and Kendal during the dry season of 2020. Environmental variables were measured in situ, and the heavy …

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Health Impacts From Pm2.5 Exposure Using Environmental Epidemiology And Health Risk Assessment: A Review, Thanakon Sukuman, Kayo Ueda, Sarunya Sujaritpong, Hirunwut Praekunatham, Kornwipa Punnasiri, Tuangsit Wimuktayon, Trakarn Prapaspongsa Jan 2023

Health Impacts From Pm2.5 Exposure Using Environmental Epidemiology And Health Risk Assessment: A Review, Thanakon Sukuman, Kayo Ueda, Sarunya Sujaritpong, Hirunwut Praekunatham, Kornwipa Punnasiri, Tuangsit Wimuktayon, Trakarn Prapaspongsa

Applied Environmental Research

Exposure to PM2.5 has been known to cause a variety of serious health consequences. Quantifying and investigating the health effects of PM2.5 pollution are imperative to understand and collect scientific evidence for supporting policies and associated actions. In this paper, we reviewed published environ-mental epidemiological studies and health risk assessments evaluating the health impacts of PM2.5 exposure in the PubMed database to identify the attributes of each method and aggregate the health impact results to perform analyses and summaries. Forty-two studies were identified after applying our search strategy, inclusion, and exclusion criteria. The epidemiological studies found an increased risk of …

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Banana Stem (Musa Balbisiana Colla) As Potential Biosorbent To Remove Methylene Blue Dye In Wastewater: Isotherm, Kinetic, Thermodynamic Studies And Its Application, Rahmiana Zein, Clalitya Akmal, Safni Safni, Syiffa Fauzia, Putri Ramadhani Jan 2023

Banana Stem (Musa Balbisiana Colla) As Potential Biosorbent To Remove Methylene Blue Dye In Wastewater: Isotherm, Kinetic, Thermodynamic Studies And Its Application, Rahmiana Zein, Clalitya Akmal, Safni Safni, Syiffa Fauzia, Putri Ramadhani

Applied Environmental Research

Textile industries discharge various waste including dye waste to the environment. Dye waste such as methylene blue taints both aquatic and land ecosystem. Thus, the recent study employs banana stem (Musa balbisiana Colla), as an economical and environmentally friendly biosorbent for methylene blue removal. The chemically activated banana stem indicates the significant methylene blue uptake at pH 5, initial concentration of 800 mg L-1, contact time of 60 min, temperature at 25 °C with adsorption capacity of 71.5470 mg g-1. The adsorption process follows the Langmuir isotherm model (R2 = 0.9965) and pseudo order model which involve monolayer …

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Potential Factors Of Landslide Recurrence In Uttaradit, Thailand: A Case Study In Laplae, Mueang Uttaradit, And Tha Pla Districts, Panithan Sawatdikomon, Watit Khokthong, Nipada Santha Jan 2023

Potential Factors Of Landslide Recurrence In Uttaradit, Thailand: A Case Study In Laplae, Mueang Uttaradit, And Tha Pla Districts, Panithan Sawatdikomon, Watit Khokthong, Nipada Santha

Applied Environmental Research

Laplae, Mueang Uttaradit, and Tha Pla district, Uttaradit province, Thailand are considered as high potential landslide areas. Still, this disaster is difficult to address because of complex factors controlling its occurrence. Therefore, the prediction of the potential landslide area using a landslide susceptibility map has been able to accomplish as a great strategy for the disaster.  A landslide susceptibility map was produced by the geographic information system (GIS) data. The methods were initially conducted by the selection of potential factors related to landslides, which were lithology, slope, aspect, plan curvature, profile curvature, distance to stream, land use, and rainfall. All …

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Application Of Fe3o4/Thiamine Magnetic Particles In The Removal Of Methylene Blue, Lan Tran-Nguyen, Suong Mai-Thi-Thu, Thanh-Ty Nguyen, Kim-Phung Ly, Luu-Ngoc-Hanh Cao, Tran Thi Bich Quyen, Shella Permatasari Santoso, Nguyen-Phuong-Dung Tran, Nguyen Minh Nhut Jan 2023

Application Of Fe3o4/Thiamine Magnetic Particles In The Removal Of Methylene Blue, Lan Tran-Nguyen, Suong Mai-Thi-Thu, Thanh-Ty Nguyen, Kim-Phung Ly, Luu-Ngoc-Hanh Cao, Tran Thi Bich Quyen, Shella Permatasari Santoso, Nguyen-Phuong-Dung Tran, Nguyen Minh Nhut

Applied Environmental Research

Fe3O4/thiamine particles were prepared in this work via precipitation method. The synthesis method is based on the principle of precipitation of Fe3O4 particles in the presence of thiamine coating agent. Also, the potential application of Fe3O4/ thiamine in the removal of methylene blue (MB) was investigated. Several factors that affect the synthesis of Fe3O4/thiamine such as base concentration, mass ratio of FeCl2 to thiamine, reaction temperature, and reaction time were determined. Optimal conditions for preparing Fe3O4/thiamine are NH4OH concentration = 10%, mass ratio of FeCl2:thiamine = 5:1 (g g-1), reaction temperature = 30 °C, reaction time = 120 min. The …

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Assessing The Compliance Of A Coastal Municipality To The Ecological Solid Waste Management Act Of 2000 (Ra 9003), Michelle Del Rosario Jan 2023

Assessing The Compliance Of A Coastal Municipality To The Ecological Solid Waste Management Act Of 2000 (Ra 9003), Michelle Del Rosario

Applied Environmental Research

To bring about a significant change in the SWM situation in the Philippines, the Ecological Solid Waste Management Act of 2000 (RA 9003) was enacted to provide local government units with frameworks that would help them solve the looming garbage problem in the country. Despite the presence of the decree, managing wastes remains a problem in the country particularly in the CALABARZON. This study was conducted to assess the extent of compliance of a coastal municipality to RA 9003 in terms of institutional mechanism, comprehensive solid waste management, incentives, and financial solid waste management and compare the assessments of 72 …

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The Effect Of Incubation Time And Drainage Ph On The Immobilization Of Copper In Post Coal Mine Soil Using Sumatera Brown Coal Char, Muhammad Haviz, Damris Muhammad, Maria Vabylita, Miftahul Djana, Rizka Mayasari, Ashruri -, Sandri Erfani, Yuli Darni, Opik Taufik Purwadi, Simparmin Ginting Jan 2023

The Effect Of Incubation Time And Drainage Ph On The Immobilization Of Copper In Post Coal Mine Soil Using Sumatera Brown Coal Char, Muhammad Haviz, Damris Muhammad, Maria Vabylita, Miftahul Djana, Rizka Mayasari, Ashruri -, Sandri Erfani, Yuli Darni, Opik Taufik Purwadi, Simparmin Ginting

Applied Environmental Research

Post coal mine (PCM) activities pose significant environmental challenges. Soils affected by PCM often exhibit increased acidity and elevated levels of heavy metals. In the case of Sungai Buluh PCM in the Jambi Province, Indonesia, copper (Cu) levels in the soil reach 94.79 mg kg-1, surpassing the Indonesian standard of 40 mg kg-1. Sumatera brown coal (SBC), typically is not considered as fuel due to its properties, offers a cost-effective solution for Cu immobilization in such soils. In this study, SBC was subjected to pyrolysis at 400°C for 1 h, sieved through a 10-mesh sieve, and characterized using SEM and …

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Dual-Polarimetric Radar Applications For Investigating Severe Thunderstorms In Northern Thailand During The Pre-Monsoon Season, Nattapon Mahavik, Sarintip Tantanee, Fatah Masthawee Jan 2023

Dual-Polarimetric Radar Applications For Investigating Severe Thunderstorms In Northern Thailand During The Pre-Monsoon Season, Nattapon Mahavik, Sarintip Tantanee, Fatah Masthawee

Applied Environmental Research

Understanding the physical characteristics of severe pre-monsoon thunderstorms is crucial for mitigating the adverse impacts of natural disasters on people in tropical regions. On April 23, 2020, a severe storm affected the Chiang Khong District of the Chiang Rai Province in Northern Thailand, causing devastation to more than 500 houses with hail and strong winds. This study investigated the storm's physical characteristics using dual-polarimetric radar data from the Thai Meteo-rological Department (TMD). Using a combination of polarimetric radar variables, such as reflectivity (ZH), specific differential phase (KDP), differential reflectivity (ZDR), and copolar correlation coefficient (ρhv), fuzzy logic was utilized to …

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Distribution Of Exchangeable Magnesium In Lowland Rice-Cultivated Soils Of Sri Lanka As Affected By The Differences In Climate, Soil, And Water Source, Indeera Hetti Arachchige, Buddhi Marambe, Mohomad Nijamudeen, Harsha Kadupitiya, Dinaratne Sirisena, Rohana Chandrajith, Lalith Suriyagoda Jan 2023

Distribution Of Exchangeable Magnesium In Lowland Rice-Cultivated Soils Of Sri Lanka As Affected By The Differences In Climate, Soil, And Water Source, Indeera Hetti Arachchige, Buddhi Marambe, Mohomad Nijamudeen, Harsha Kadupitiya, Dinaratne Sirisena, Rohana Chandrajith, Lalith Suriyagoda

Applied Environmental Research

Magnesium (Mg) is an essential macronutrient for plants. Even though Sri Lankans consume rice as the staple food, the Mg status in Sri Lankan paddy soils as affected by its climate, soils, and water sources used are not well understood. This study was conducted to (i) determine the distribution of exchangeable Mg (ex-Mg) concentration, and (ii) examine the interactive effects of agro-climatic zones (ACZs), soil order, and water source in determining the ex-Mg concentra-tion in lowland paddy fields of Sri Lanka. A total of 9,038 soil samples representing six ACZs, six soil orders, and three water sources were collected using …

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The Effect Of Irrigation Techniques On Sustainable Water Management For Rice Cultivation System - A Review, Bittawat Wichaidist, Amornrat Intrman, Songsak Puttrawutichai, Chawakorn Rewtragulpaibul, Supatchaya Chuanpongpanich, Chaisri Suksaroj Jan 2023

The Effect Of Irrigation Techniques On Sustainable Water Management For Rice Cultivation System - A Review, Bittawat Wichaidist, Amornrat Intrman, Songsak Puttrawutichai, Chawakorn Rewtragulpaibul, Supatchaya Chuanpongpanich, Chaisri Suksaroj

Applied Environmental Research

Rice serves as a fundamental sustenance for approximately half of the global population, particularly in Asia. Nevertheless, the cultivation of rice demands a substantial water supply, and the challenges associated with water deficits have been exacerbated by irregular rainfall patterns induced by global warming. Consequently, there is a critical need to reassess irrigation techniques to effectively tackle these issues. In this comprehensive review, the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) method was employed to systematically explore literature on irrigation techniques aimed at fostering sustainable water management in rice cultivation systems. The primary components of the framework encompass …

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Docking, Synthesis Of Some Novel Flavonoid Analogues, And Their Biological Evaluation, Ishwar Bhat K, Afiya Abdul Aziz, Abhishek Kumar, Vijaya Bhaskar K, Vijay Kumar M Jan 2023

Docking, Synthesis Of Some Novel Flavonoid Analogues, And Their Biological Evaluation, Ishwar Bhat K, Afiya Abdul Aziz, Abhishek Kumar, Vijaya Bhaskar K, Vijay Kumar M

The Thai Journal of Pharmaceutical Sciences

Cancer remains a major class of morbidity and mortality despite basic and clinical research and trials of promising new therapies. In the current era, many drugs are marketed with flavonoid nucleus. Based on this information, this study aims to synthesize and screen flavones for their anticancer activity. Docking studies for cytotoxic activity of flavonoid derivatives targeting tankyrase enzyme were performed. A new series of flavonoid derivatives were prepared from chalcones. Chalcones were prepared between substituted benzaldehyde and 2-hydroxy acetophenone in the presence of potassium hydroxide as catalyst. The flavone derivatives were characterized based on IR, 1H NMR, and Mass spectral …

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Application Of Concept Mapping In Telepharmacy Model Development For Prescription Filling At Primary Care Clusters, Nusaraporn Kessomboon, Siwapond Prasertsuk, Jirachaya Suttima, Nur-Ainee Korsem Jan 2023

Application Of Concept Mapping In Telepharmacy Model Development For Prescription Filling At Primary Care Clusters, Nusaraporn Kessomboon, Siwapond Prasertsuk, Jirachaya Suttima, Nur-Ainee Korsem

The Thai Journal of Pharmaceutical Sciences

Background: Although the Pharmacy Council of Thailand has announced a standard telepharmacy service procedure, there may be some details or limitations that are specific to the primary care cluster (PCC) in the real situation. Objective: This research aimed to create a telepharmacy service model for the PCC using concept mapping techniques. Methodology: Group discussions were held, each participant will submit their opinions and graded of importance and possibilities of each opinion. After that, the data obtained were statistically analyzed to create a concept mapping. Results: From the group discussion, (n = 10) can be concluded that the optimum telepharmacy services …

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Effects Of Quercetin And Its Derivatives On Mirnas And Inflammatory Mediators In Inflammation: A Systematic Review, Benediktus Wastu Paramabodhi, Eva Annisaa, Widyandani Sasikirana, Wimzy Rizqy Prabhata Jan 2023

Effects Of Quercetin And Its Derivatives On Mirnas And Inflammatory Mediators In Inflammation: A Systematic Review, Benediktus Wastu Paramabodhi, Eva Annisaa, Widyandani Sasikirana, Wimzy Rizqy Prabhata

The Thai Journal of Pharmaceutical Sciences

Quercetin has been known to have anti-inflammatory effects. Information regarding the anti-inflammatory effects of quercetin or its derivatives on inflammatory mediators and miRNAs is abundant and varied. However, a comprehensive understanding of its pharmacological actions at the cellular and molecular levels needs to be studied. Therefore, quercetin and its derivatives were studied in this systematic review to investigate how they affect the expressions of miRNAs and inflammatory mediators and their respective roles in the mechanisms of anti-inflammatory actions. A literature search in PubMed and Scopus databases was carried out based on the PRISMA protocol. Out of 2964 articles identified, 47 …

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Anti-Diabetic Activity Of Bauhinia Strychnifolia Craib Stem Extract In Alloxan-Induced Diabetic Rats, Peerarat Thaina, Nattapaul Rattanamusik, Teepakorn Saraphee, Suriyan Tengyai, Attarat Pattanawongsa, Panupong Puttarak Jan 2023

Anti-Diabetic Activity Of Bauhinia Strychnifolia Craib Stem Extract In Alloxan-Induced Diabetic Rats, Peerarat Thaina, Nattapaul Rattanamusik, Teepakorn Saraphee, Suriyan Tengyai, Attarat Pattanawongsa, Panupong Puttarak

The Thai Journal of Pharmaceutical Sciences

The α-glucosidase inhibitory and antioxidant activities of Bauhinia strychnifolia Craib in vitro have been explored; however, its effectiveness in vivo is still unknown. This study examined the hypoglycemic effects of B. strychnifolia extract. Acute toxicity was also investigated in mice using the up-and-down method. The experiments were carried out in both sexes of Wistar rats and female ICR mice. The results showed that the oral LD50 of the plant extract was greater than 5000 mg/kg. For the anti-diabetic investigation, diabetes was induced in rats by subcutaneous injection of alloxan (125 mg/kg). The hypoglycemic effect was evaluated by oral administration of …

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In-Vivo Antidiabetic Activity And In-Silico Mode Of Action Of Gc-Ms Identified Phytoconstituents In Rhynshosia Cana, Praveena Yempada, Arya Lakshmi Marrisetti, Ganga Rao Battu Jan 2023

In-Vivo Antidiabetic Activity And In-Silico Mode Of Action Of Gc-Ms Identified Phytoconstituents In Rhynshosia Cana, Praveena Yempada, Arya Lakshmi Marrisetti, Ganga Rao Battu

The Thai Journal of Pharmaceutical Sciences

Plants have been a primary medicinal source for thousands of years and are utilized time immemorial as popular traditional folk medicine. Rhynchosia cana (R. cana) had therapeutic qualities. In this research, the entire plant R. cana was exposed to maceration with methanol. This plant's methanol extract (MERC) was tested using Gas Chromatography-Mass Spectrometry (GC-MS), which shows 11 main components. Compounds discovered in-silico mechanism of action showed inhibition of α-Amylase and α-glucosidase enzymes. In vitro technique, the MERC also showed α-Amylase and α-glucosidase inhibition. Streptozocin-induced diabetes model evaluated the antihyperglycemic activity in vivo. Single intraperitoneal Streptozotocin injection at a dosage of …

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The Type Of Pharmacy Ownership And Its Impact On Service Quality And Regulatory Compliance In Community Pharmacies, Afshin Azari, Farzad Peiravian, Nazila Yousefi Jan 2023

The Type Of Pharmacy Ownership And Its Impact On Service Quality And Regulatory Compliance In Community Pharmacies, Afshin Azari, Farzad Peiravian, Nazila Yousefi

The Thai Journal of Pharmaceutical Sciences

Community pharmacies have always played an important role in the health system. Therefore, having a decent service provided by pharmacies is of paramount importance for the healthcare systems. The issue of pharmacy ownership and its possible impact on the quality of services as well as the number of violations, has been argued for many years. However, no research has been performed to investigate this issue, especially in Iran. This study investigates the impact of pharmacists’ and non-pharmacists’ ownership on the pharmacies’ violations and their service quality. Violations were examined using official pharmacy inspection reports and service quality was examined using …

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Characterization Of Quality Attribute And Specification For Standardization Of Acemannan Extracted From Aloe Vera For Tissue Regeneration, Siriwan Seeleamngam, Polkit Sangvanich, Pasutha Thunyakitpisal, Vorasit Vongsutilers Jan 2023

Characterization Of Quality Attribute And Specification For Standardization Of Acemannan Extracted From Aloe Vera For Tissue Regeneration, Siriwan Seeleamngam, Polkit Sangvanich, Pasutha Thunyakitpisal, Vorasit Vongsutilers

The Thai Journal of Pharmaceutical Sciences

Acemannan extracted from Aloe vera was well characterized as an acetylated mannose polysaccharide which have promising clinical profile for tissue regeneration. Quality aspect of acemannan is required to develop the herbal extract for practical industrial application and reliable therapeutic use. The research aim is to investigate the qualify attributes of acemannan that have impact on its safety and efficacy. Quality of three production batches of acemannan were evaluated based on ICH quality guidelines and pharmacopeial standard. The quality aspect of acemannan were determined by analytical technique including FT-IR, SEC-HPLC, RP-HPLC, GC, and loss on drying to ensure its identify and …

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Hepatotoxic Effect Of Cadmium And Available Therapeutic Options, Tomilola Olaolu, Favour Jibulu, Rotimi Damilare Jan 2023

Hepatotoxic Effect Of Cadmium And Available Therapeutic Options, Tomilola Olaolu, Favour Jibulu, Rotimi Damilare

The Thai Journal of Pharmaceutical Sciences

Hepatoxicity, also known as toxic hepatitis, is a condition, in which the liver becomes inflamed due to exposure to such substances as chemicals, medications, herbal products, or excessive alcohol consumption. Cadmium is a major environmental pollutant from agricultural and industrial sources and has been reported to induce hepatotoxicity. Cadmium can also be found in phosphate fertilizers, detergents, and refined petroleum products as an impurity and used industrially in the production of polyvinyl chloride product stabilizers and the fabrication of nickel-cadmium batteries. Cadmium can be absorbed into the human body through the gastrointestinal tract, respiratory, and dermal routes. Cadmium-induced hepatic damage …

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Neuroprotective Effect Of Isolated Palmatine From Tinospora Cordifolia (Thunb.) Miers Leaves In Aluminium Chloride Induced Oxidative Stress, Kuntal Das, B. Ratna, S. V. Rajendra Jan 2023

Neuroprotective Effect Of Isolated Palmatine From Tinospora Cordifolia (Thunb.) Miers Leaves In Aluminium Chloride Induced Oxidative Stress, Kuntal Das, B. Ratna, S. V. Rajendra

The Thai Journal of Pharmaceutical Sciences

The present study aimed at determining the neuroprotective role of palmatine isolated from Tinospora cordifolia (TC) leaves on neurobehavioral parameters in aluminium chloride induced oxidative stress and to assess the biochemical and histopathological alterations brought about by the same on mouse brain. Isolated Palmatine showed antioxidant potential confirmed with DPPH assay. The purity of the isolated palmatine was confirmed with FTIR, C-13 NMR and mass spectroscopy. Four groups of animals with doses of 10 and 20mg/kg respectively were studied against aluminium chloride induced oxidative stress (100mg/kg) for the alterations it brought in neurobehavioral parameters using actophotometer, rotarod test, Morris water …

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Risk Assessment Of Gmp Inspection Of Overseas Pharmaceutical Manufacturers Based On Desktop Inspection As Required In Thailand, Varin Titapiwatanakun, Waranon Cheewajorn, Narueporn Sutanthavibul Jan 2023

Risk Assessment Of Gmp Inspection Of Overseas Pharmaceutical Manufacturers Based On Desktop Inspection As Required In Thailand, Varin Titapiwatanakun, Waranon Cheewajorn, Narueporn Sutanthavibul

The Thai Journal of Pharmaceutical Sciences

Good manufacturing practice (GMP) inspection of overseas manufacturers in Thailand is regulated under desktop inspection that is verified mainly by documents. Thus the inspection results may cause certain gaps in terms of quality and reliability, particularly when compared with on-site inspection. This work utilized the pharmaceutical quality risk management in the International Council for Harmonization Q9 guideline with Failure Mode and Effects Analysis (FMEA) tool to study and manage potential risks. The study design consisted of five steps. First, a pre-assessment step was to set up a team to consider a data analysis of the inspection data and drug quality …

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Analysis Of Phytochemical Potential And Investigation Of Hypoglycemic Effect Of Cassia Fistula L. Fruit Wall Extracts By Alpha-Amylase Assay And Streptozotocin Induced Diabetic Rat Model., Samreen Tanveer, Athar Masood, Seemab Ali, Afshan Arshad Jan 2023

Analysis Of Phytochemical Potential And Investigation Of Hypoglycemic Effect Of Cassia Fistula L. Fruit Wall Extracts By Alpha-Amylase Assay And Streptozotocin Induced Diabetic Rat Model., Samreen Tanveer, Athar Masood, Seemab Ali, Afshan Arshad

The Thai Journal of Pharmaceutical Sciences

This study will estimate the proximate composition of phytochemicals and study the hypoglycemic effect of Cassia fistula Linn fruit wall extracts. Materials and methods: The in vitro inhibition of alpha-amylase and in vivo streptozotocin induce diabetes model was applied to investigate the anti-diabetic activity. For standardization, Atomic Absorption Spectroscopy and FTIR were used. Results: Proximate analysis values were found to be within the specific limits as recommended by the British Pharmacopeia. The FTIR spectrum and elemental analysis confirmed occurrence of various functional groups and minerals. The phytochemical analysis indicates the higher fraction of the carbohydrates (69.89%) and relatively lesser proportion …

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Development Of Amino Acid Salt-Based Curcumin@Lysine Acetate Co-Amorphous System Using Liquid-Assisted Grinding For Improved Solubility And Dissolution, Udaykumar Patil, Snehal Rawal, Jidnyasa Pantwalawalkar, Sopan Nangare, Dilip Dagade, Pravin Patil, Namdeo R. Jadhav Jan 2023

Development Of Amino Acid Salt-Based Curcumin@Lysine Acetate Co-Amorphous System Using Liquid-Assisted Grinding For Improved Solubility And Dissolution, Udaykumar Patil, Snehal Rawal, Jidnyasa Pantwalawalkar, Sopan Nangare, Dilip Dagade, Pravin Patil, Namdeo R. Jadhav

The Thai Journal of Pharmaceutical Sciences

Curcumin, multivalued phytoceutical, exhibits appreciable safety. However, its therapeutic utility is significantly compromised due to low aqueous solubility, and thus, poor absorption and low bioavailability become apparent. To surpass this limitation, the present work aims to develop amino acid salt-based curcumin@lysine acetate co-amorphous system for improved solubility and dissolution. Initially, screening of curcumin-amino acid mixtures was performed for saturation solubility assessment. Considering the outcome, lysine acetate was formulated to generate a co-amorphous mixture (COAM) by liquid-assisted grinding and evaluated for saturation solubility and different spectroscopical characterizations. Curcumin-lysine acetate COAM tablet formulation was developed by direct compression method and evaluated for …

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