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Knowledge, Attitude And Practice Of Human Papilloma Virus Vaccination Among Reproductive Age Women In Mandalay City, Myanmar: A Cross-Sectional Study, Kyi Thu Jan 2023

Knowledge, Attitude And Practice Of Human Papilloma Virus Vaccination Among Reproductive Age Women In Mandalay City, Myanmar: A Cross-Sectional Study, Kyi Thu

Chulalongkorn University Theses and Dissertations (Chula ETD)

Cervical cancer is the fourth most common type of cancer among women all over the world. HPV infection, the most sexually transmitted viral infection, is responsible for about 95% of cases of cervical cancer. The study aims to investigate the association between socio-demographic characteristics, knowledge level, and attitude level toward the practice of HPV vaccination among reproductive age women in Mandalay City, Myanmar. The cross-sectional study was conducted in May 2024 among reproductive age women in Mandalay City in Myanmar. The study used an online, standard questionnaire. Descriptive statistics, simple logistic regression, and multiple logistics regression models were used for …

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Effects Of A Game On A Smartphone (“Pilotgold”)To Prevent Non-Specific Neck Pain Among Office Workers:A 6-Month Cluster-Randomised Controlled Trial, Natchanon Intipanya Jan 2023

Effects Of A Game On A Smartphone (“Pilotgold”)To Prevent Non-Specific Neck Pain Among Office Workers:A 6-Month Cluster-Randomised Controlled Trial, Natchanon Intipanya

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: To evaluate the effects of a smartphone game for active neck movement exercise on perceived neck discomfort, new onset neck pain, and active cervical range of motion (ROM) among high-risk office workers. Methods: A 6-month prospective cluster-randomized controlled trial was conducted involving 100 healthy but high-risk office workers from nine organizations. They were randomly assigned at the cluster level into either the intervention group (n = 50), who received a smartphone game to play twice a day on workdays for 6 months, or the control group (n = 50), who received a placebo seat pad to use while sitting. …

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Association Between Greenness And Environmental Parameters Exposure And Depression Among Residents In Bangkok, Thailand: An Ecological Longitudinal Study, Wilaipak Nilsalai Jan 2023

Association Between Greenness And Environmental Parameters Exposure And Depression Among Residents In Bangkok, Thailand: An Ecological Longitudinal Study, Wilaipak Nilsalai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Depression and mental health issues are on the rise, and it is hypothesized that environmental factors may play a role in the development of these diseases. Greenness is one of the potential factors, and this study aims to investigate the relationship between living in greener areas and depression incidence in Bangkok. This is an ecological longitudinal study using secondary data documented between 2018 and 2020, utilizing data on depression (ICD-10 F32, F33), environmental parameters (PM2.5 (µg/m3), temperature (ºC), relative humidity (RH; %), and demographic variables (population density, number of communities, number of hospitals, number of healthcare centers, and divorce rate) …

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Perception Of Academic Stress And Family Relationship On Mental Well-Being Among Pharmacy Students At Chulalongkorn University In Thailand: A Cross-Sectional Survey Study, Chompunoot Prasongpol Jan 2023

Perception Of Academic Stress And Family Relationship On Mental Well-Being Among Pharmacy Students At Chulalongkorn University In Thailand: A Cross-Sectional Survey Study, Chompunoot Prasongpol

Chulalongkorn University Theses and Dissertations (Chula ETD)

University students' mental health and well-being have gained more global attention due to their increasing influence on health and societal issues. The cross-sectional study, conducted in May 2024 among undergraduate Chulalongkorn University pharmacy students in Thailand, aims to investigate the proportion of mental well-being levels and determine the relationship between general characteristics, perceptions of academic stress, and family relationships toward mental well-being levels among pharmacy students at Chulalongkorn University. The study used an online, self-administered questionnaire. Descriptive statistics, simple logistic regression, and multiple logistic regression models were employed for data analysis. Out of 289 pharmacy students, 199 were predominantly female …

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Roles Of Progesterone Signaling On Dna Repair And Cell Survival In Ovarian Cancer Cells, Pattarasiri Rangsrikitphoti Jan 2023

Roles Of Progesterone Signaling On Dna Repair And Cell Survival In Ovarian Cancer Cells, Pattarasiri Rangsrikitphoti

Chulalongkorn University Theses and Dissertations (Chula ETD)

Every year over 300,000 women worldwide are diagnosed with ovarian cancer and half of these patients die from this disease. The symptoms of ovarian cancer are very general and often confused with other common female diseases making ovarian cancer a challenging disease to diagnose and treat. Platinum-based chemotherapy, including cisplatin, stands as the first-line treatment for ovarian cancer. However, chemotherapy resistance remains a continuing problem, contributing to a high mortality rate. Progesterone receptor (PR) signaling has been implicated in various aspects of ovarian cancer biology. Clinical studies show a positive correlation between PR expression, improved patient survival and cisplatin response, …

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Associated Factors With Suicide Mortality In Thailand:A Mediating Roles Of Urban And Rural Areas, Kajohnsak Tangkwampien Jan 2023

Associated Factors With Suicide Mortality In Thailand:A Mediating Roles Of Urban And Rural Areas, Kajohnsak Tangkwampien

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Suicide is a global public health problem that affects individuals, families, and communities. The World Health Organization (WHO) estimates that more than 700,000 people die by suicide worldwide each year. Despite the significance of this issue, important factors like rural and urban settings, which have different definitions in each country and result in specific contextual effects on suicide, are overlooked. Objectives: To understand the role of living in urban and rural as mediator on the associated factors (socio-demographic factors, mental and physical problems, effect from COVID-19, economic factors, relationship problems, history of self-harm, and warning signs, method of suicide) …

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Comparison Of The Effects Of Dynamic Seat Cushion At Low Back And Buttocks On The Number Of Postural Shifts And Body Perceived Discomfort In Office Workers, Narumon Roynarin Jan 2023

Comparison Of The Effects Of Dynamic Seat Cushion At Low Back And Buttocks On The Number Of Postural Shifts And Body Perceived Discomfort In Office Workers, Narumon Roynarin

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study compared the number of postural shifts and body perceived discomfort while leaning and sitting on air-filled seat cushion for 1-hour in healthy office workers. Sixty office workers typed a standard text at a computer workstation for an hour in three sitting conditions: leaning on a seat cushion placing behind the low back, sitting on a seat cushion placing under the buttocks, and sitting without a seat cushion (a control condition). The number of postural shifts, average pressure (AP), peak pressure (PP), and frequency of sitting posture were collected using a seat pressure mat device. Body perceived discomfort at …

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Ultrasound-Assisted Extraction Of Cannabis Sativa And Biological Activities Assessments For Dermatological Application, Pannita Kongtananeti Jan 2023

Ultrasound-Assisted Extraction Of Cannabis Sativa And Biological Activities Assessments For Dermatological Application, Pannita Kongtananeti

Chulalongkorn University Theses and Dissertations (Chula ETD)

Cannabis sativa L. is a medicinal plant that has long been used in Thai traditional medicine and is still widely used today, with many uses in pharmaceuticals, including the treatment of skin infections. It contains a complex mixture of secondary metabolites, including cannabinoids and non-cannabinoid-type constituents, especially detla-9-tetrahydrocannabinol (THC), cannabidiol (CBD), and terpenes. However, fewer studies of cannabis have been reported regarding its anti-aging potential by investigating tyrosinase inhibition activity. In this study, ultrasound-assisted extraction (UAE) of 5 different parts of Cannabis sativa L., the determination of bioactive compounds using GC–MS/MS and the assessment of their biological properties related to …

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Superconductivity In 2d Janus Monolayers And Bilayers, M Munib Ul Hassan Noor Ul Taqi Jan 2023

Superconductivity In 2d Janus Monolayers And Bilayers, M Munib Ul Hassan Noor Ul Taqi

Chulalongkorn University Theses and Dissertations (Chula ETD)

Janus transition metal dichalcogenides (J-TMDCs) is a new class of materials which shares the same honey-comb structure as graphene and conventional transition metal dichalcogenides (TMDCs) in monolayer. They have versatile physical and chemical properties which mainly feature out from their broken out of plane symmetry. This asymmetry results in an intrinsic electric field orthogonal to their plan. The presence of an intrinsic electric field gives rise to many novel properties like the Rashba effect, increased charge carrier concentration, Schottky barrier, excitons, and superconductivity. Also, they exist in multiple structural phases like, 2H, 1T, 1T' with the electrical properties shifting from …

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Effects Of A Therapeutic Lifestyle Modification Intervention On Cardio-Metabolic Health, Sexual Functioning, And Health-Related Quality Of Life In Perimenopausal Chinese Women: A Randomized Controlled Trial, Yuru Wang Jan 2023

Effects Of A Therapeutic Lifestyle Modification Intervention On Cardio-Metabolic Health, Sexual Functioning, And Health-Related Quality Of Life In Perimenopausal Chinese Women: A Randomized Controlled Trial, Yuru Wang

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: Our study aimed to explore the effects of a therapeutic lifestyle modification (TLM) intervention on cardiometabolic health, sexual functioning, and health-related quality of life in perimenopausal Chinese women. Methods: This was a 12-week, two-parallel arm, randomized controlled trial conducted in the First Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming City, China. Ninety-four eligible perimenopausal women aged between 40 and 55 years were randomly assigned to either a TLM intervention or usual care at a 1:1 ratio. Menopause-specific quality of life (MENQOL), female sexual function index (FSFI), pelvic floor muscle strength (PFMS), and composite cardiometabolic biomarkers were evaluated …

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ผลการฝึกสตาร์เอ็กเคอร์ชั่นร่วมกับชุดอุปกรณ์ควบคุมท่าทางต่อความสามารถในการทรงตัวและความแข็งแรงกล้ามเนื้อรยางค์ขาในผู้สูงอายุเพศหญิง, พิชชา พะกาวัลย์ Jan 2023

ผลการฝึกสตาร์เอ็กเคอร์ชั่นร่วมกับชุดอุปกรณ์ควบคุมท่าทางต่อความสามารถในการทรงตัวและความแข็งแรงกล้ามเนื้อรยางค์ขาในผู้สูงอายุเพศหญิง, พิชชา พะกาวัลย์

Chulalongkorn University Theses and Dissertations (Chula ETD)

การวิจัยในครั้งนี้มีวัตถุประสงค์เพื่อศึกษาผลการฝึกสตาร์เอ็กเคอร์ชั่นร่วมกับชุดอุปกรณ์ควบคุมท่าทางต่อความสามารถในการทรงตัว ความแข็งแรง และความยืดหยุ่นของกล้ามเนื้อรยางค์ขา และความกลัวการหกล้มในผู้สูงอายุเพศหญิง กลุ่มตัวอย่างเป็นผู้สูงอายุเพศหญิงที่มีสุขภาพดี อายุ 65 ถึง 75 ปี จำนวน 36 คน แบ่งเป็น 2 กลุ่ม โดยวิธีการแบ่งกลุ่มด้วยการจับคู่ตามอายุและคะแนนการทดสอบการทรงตัวด้วยการยืนขาเดียว ได้แก่ กลุ่มควบคุม ไม่ได้รับการฝึกออกกำลังกาย และดำเนินชีวิตประจำวันตามปกติ และกลุ่มทดลองได้รับการฝึกสตาร์เอ็กเคอร์ชั่นร่วมกับชุดอุปกรณ์ควบคุมท่าทาง ใช้ระยะเวลาในการฝึก 60 นาทีต่อครั้งเป็นระยะเวลา 8 สัปดาห์ ๆ ละ 3 วัน ก่อนและหลังการฝึกทำการทดสอบตัวแปรด้านองค์ประกอบของร่างกาย ความสามารถในการทรงตัว ความแข็งแรงกล้ามเนื้อ ความยืดหยุ่นของกล้ามเนื้อและข้อต่อรยางค์ขา และความกลัวการหกล้ม เมื่อได้ข้อมูลทำการวิเคราะห์สถิติการแจกแจงของข้อมูลด้วยการทดสอบชาพิโร-วิลค์ นำข้อมูลที่มีการแจกแจงแบบปกติมาวิเคราะห์เปรียบเทียบโดยสถิติความแปรปรวนสองทางแบบผสมเพื่อทดสอบความแตกต่างระหว่างค่าเฉลี่ยข้อมูล และเปรียบเทียบความแตกต่างแบบรายคู่ โดยใช้วิธีการทดสอบแอลเอสดี ที่ระดับนัยสำคัญทางสถิติที่ระดับ 0.05 หลังการฝึก 8 สัปดาห์ พบว่า กลุ่มฝึกสตาร์เอ็กเคอร์ชั่นร่วมกับชุดอุปกรณ์ควบคุมท่าทางมีการพัฒนาความสามารถในการทรงตัว ความแข็งแรงกล้ามเนื้อที่ประกอบด้วย กลุ่มกล้ามเนื้อเหยียดเข่า และงอเข่า กลุ่มกล้ามเนื้องอสะโพก และเหยียดสะโพก กลุ่มกล้ามเนื้อกางสะโพก และหุบสะโพก กลุ่มกล้ามเนื้อถีบปลายข้อเท้าทั้งสองข้างที่ทดสอบ และมีจำนวนครั้งในการทดสอบลุกนั่ง 30 วินาทีเพิ่มขึ้น และความยืดหยุ่นของมุมการกางข้อสะโพกข้างซ้าย และมุมการกระดกปลายข้อเท้าข้างซ้ายเพิ่มขึ้น และมุมการงอข้อเข่าทั้งสองข้างเพิ่มขึ้นแตกต่างจากกลุ่มควบคุมอย่างมีนัยสำคัญทางสถิติที่ระดับ 0.05 สรุปได้ว่า การฝึกสตาร์เอ็กเคอร์ชั่นร่วมกับชุดอุปกรณ์ควบคุมท่าทางสามารถเป็นทางเลือกในการออกกำลังกายที่ปลอดภัย และสามารถพัฒนาความสามารถในการทรงตัว ความแข็งแรงและความยืดหยุ่นของกล้ามเนื้อรยางค์ขา และความกลัวการหกล้มในผู้สูงอายุเพศหญิง

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Electrophysiological Characteristics Of A Novel Scn5a Mutation (I239v Or M1487k) In The Cardiac Voltage-Gated Sodium Channel, Vichaya Auvichayapat Jan 2023

Electrophysiological Characteristics Of A Novel Scn5a Mutation (I239v Or M1487k) In The Cardiac Voltage-Gated Sodium Channel, Vichaya Auvichayapat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Cardiac voltage-gated sodium channels (NaV1.5) are essential to generate sodium current (INa) and regulate cardiac electrical conduction. Mutations in NaV1.5 can lead to cardiac disorders such as Brugada syndrome and Long QT Syndrome type 3 (LQTS3), potentially resulting in sudden cardiac death. Mutations p.I239V and p.M1487K have been identified in LQTS3 patients. The p.I239V mutation was found in a patient with mild symptoms and in family members who experienced sudden cardiac death, while the p.M1487K mutation is associated with more severe symptoms. This study aims to investigate the impact of these mutations on INa from NaV1.5 activities, which could cause …

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Stability Analysis Of Cellular Steel Plane Frames, Voraphol Horsangchai Jan 2023

Stability Analysis Of Cellular Steel Plane Frames, Voraphol Horsangchai

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research presents a comprehensive investigation of the global stability of cellular steel columns, beam-columns, and frames. For the cellular steel columns, the existing equation for predicting the elastic buckling load is improved to account for the local bending deformation of the web posts. Subsequently, the column strength equation is analytically developed from the energy approach. The second-order inelastic analysis is performed using 3D finite element (FE) models and validated against the experimental results. The validated FE models are then employed to assess the developed column strength curve and examine the influence of initial imperfections on the critical strength of …

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Viral Rna M6a Methylome Profilingusing Nanopore Direct Rna Sequencing, Thada Sukprasong Jan 2023

Viral Rna M6a Methylome Profilingusing Nanopore Direct Rna Sequencing, Thada Sukprasong

Chulalongkorn University Theses and Dissertations (Chula ETD)

N6-methyladenosine (m6A) modification is the most common RNA modification in eukaryotic mRNAs and viruses, playing a pivotal role in gene regulation. Currently, nanopore sequencing has emerged as a technique capable of identifying m6A positions by observing differences in ionic currents between wild-type and METTL3-knockout samples. This method sequences native RNA strands directly, bypassing reverse transcription. The xPore program compares the ionic currents from both samples to determine m6A positions and their modification rates. However, obtaining METTL3-knockout RNAs is not always achievable. To address this limitation, m6Anet predicts m6A positions and provides the probability of m6A sites using only wild-type RNA. …

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Identification And Characterization Of Genes Involved In Antioxidant Traits In Local Thai Rice (Oryza Sativa L.), Putut Rakhmad Purnama Jan 2023

Identification And Characterization Of Genes Involved In Antioxidant Traits In Local Thai Rice (Oryza Sativa L.), Putut Rakhmad Purnama

Chulalongkorn University Theses and Dissertations (Chula ETD)

Developing rice (Oryza sativa L) cultivars with high antioxidant activities have become increasingly important since they have nutritional advantages for human health. Hence, the researchers must precisely elucidate the genetic bases controlling antioxidant-related traits in rice grains. In this study, we aimed to identify the genes involved in antioxidant traits in local Thai rice. The first strategy was conducting a genome-wide association analysis (GWAS) using 233 accessions of local Thai rice. A total of 119,541 single nucleotide polymorphic (SNP) markers was used as genotype data. In contrast, the five antioxidant assays, ABTS, DPPH, FRAP, TFC, and TFC, were used as …

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Metabolomic Analysis Of Lungs From Breast Cancer Metastatic Mice Models Treated With Thai Traditional Medical Formulary, Kotchanipa Rukruam Jan 2023

Metabolomic Analysis Of Lungs From Breast Cancer Metastatic Mice Models Treated With Thai Traditional Medical Formulary, Kotchanipa Rukruam

Chulalongkorn University Theses and Dissertations (Chula ETD)

Triple-negative breast cancer (TNBC) is a highly invasive subtype, leading to lung metastasis in 40% of patients with TNBC metastasis. Lung metastases significantly reduce median survival compared to other breast cancer types. Hence, there are efforts to investigate TNBC treatments, including modern and alternative therapies. The Thai traditional medical formulary (TTMF) is broadly used as an alternative treatment for Thai cancer patients. However, there are no studies on metabolic changes after treatment in advanced TNBC. Additionally, obtaining metabolites from biological samples is challenging due to the lack of a universal protocol for metabolite extraction. Consequently, this thesis aimed to first …

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Contamination Of Antimicrobial-Resistant Escherichia Coli, Salmonella Spp., Enterococcus Faecalis, And Enterococcus Faecium In Commercial Raw Meat-Based Diets For Cats And Dogs, Rusmin Indra Jan 2023

Contamination Of Antimicrobial-Resistant Escherichia Coli, Salmonella Spp., Enterococcus Faecalis, And Enterococcus Faecium In Commercial Raw Meat-Based Diets For Cats And Dogs, Rusmin Indra

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed to investigate the contamination of third-generation cephalosporin (3GC)-resistant Escherichia coli, Salmonella spp., Enterococcus faecalis, and E. faecium in commercial raw meat-based diets (RMBDs) for cats and dogs in Thailand. Fifty RMBD products from ten brands were included for total plate count and bacterial isolation. Antimicrobial susceptibility testing was conducted for the targeted bacteria. Extended-spectrum β-lactamase (ESBL) production and the presence of blaCTX-M and mcr genes were detected. Additionally, E. coli phylogroups and Salmonella serovars were identified. The RMBD samples were contaminated by 3GC-resistant E. coli (80.0%), Salmonella spp. (70.0%), E. faecalis (100%), and E. faecium (84.0%). All …

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National Survey Of Human Epigenetic Study In Healthy Aged Population In Four Different Regions Of Thailand, Siwaporn Nilyai Jan 2023

National Survey Of Human Epigenetic Study In Healthy Aged Population In Four Different Regions Of Thailand, Siwaporn Nilyai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Healthy ageing has become a goal to help older people maintain good-quality longevity. Researchers have found that epigenetic, environmental, and behavioural lifestyle factors influence the variation of lifespan and healthspan. This study aims to evaluate the age-associated epigenetic biomarkers among older people living in four major regions of Thailand, along with their association with lifestyle and sociodemographic characteristics. 214 participants passed the criteria and enrolled from the southern, northeastern, central, and northern areas of Thailand. Sociodemographic characteristics were recorded through interviews, and blood samples were collected to evaluate blood chemistry and epigenetic markers. SIRT1 and HMGB1 proteins in plasma were …

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Volatile Organic Compound Profiles Identifiled In Vaginal Discharge Of Bitches During Estrous Cycle, Amornthep Preechatangkit Jan 2023

Volatile Organic Compound Profiles Identifiled In Vaginal Discharge Of Bitches During Estrous Cycle, Amornthep Preechatangkit

Chulalongkorn University Theses and Dissertations (Chula ETD)

Volatile organic compounds (VOCs) are the metabolites of microorganisms. VOCs are low molecular weight and easily evaporate at room temperature, all odorants are VOC. VOCs are different depending on health status and reproductive status. The objective of this study was to profile the VOCs in bitches during estrous cycle, and to compare VOCs between stages of estrous cycle and between pre-ovulatory, ovulation and post-ovulatory periods. A total of 23 normal, healthy bitches requested for ovulation timing as part of the routine breeding management were used in this study. All animals had a previous history of normal estrous cycle without any …

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Inhibition Of Chondrocyte Apoptosis Via Fas/Fasl System In Knee Osteoarthritis Patients, Ousakorn Kamenkit Jan 2023

Inhibition Of Chondrocyte Apoptosis Via Fas/Fasl System In Knee Osteoarthritis Patients, Ousakorn Kamenkit

Chulalongkorn University Theses and Dissertations (Chula ETD)

Osteoarthritis (OA) is a degenerative rheumatic disease characterized by articular cartilage degeneration. This articular cartilage degradation is positively correlated with chondrocyte apoptosis. The Fas/Fas ligand (FasL) system is part of the extrinsic apoptosis pathway that regulates cell death through the binding of Fas on target cells to FasL on effector cells. Although Fas+ chondrocytes have been identified and the Fas/FasL system has been implicated in this apoptotic process, the apoptosis through chondrocyte-to-FasL+ cell interaction remains unclear. Therefore, this study aims to investigate Fas/FasL-mediated chondrocyte apoptosis focusing on cell-to-cell interactions. In our study, we conducted ex vivo experiments using flow cytometry …

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Genome Characterization And Significant Gene Annotation Of Mycobacteria Based On Data From High-Throughput Dna Sequencing Technology, Ajala Prommi Jan 2023

Genome Characterization And Significant Gene Annotation Of Mycobacteria Based On Data From High-Throughput Dna Sequencing Technology, Ajala Prommi

Chulalongkorn University Theses and Dissertations (Chula ETD)

Mycobacteria encompass a variety of species, including pathogenic strains such as Mycobacterium tuberculosis complex (MTBC) and nontuberculous mycobacteria (NTM). These organisms are responsible for significant health challenges globally and in Thailand, particularly due to tuberculosis (TB) and its drug-resistant forms. This dissertation aims to characterize the whole genome of various Mycobacterium species and annotate significant genes utilizing high-throughput DNA sequencing technology. Key objectives include investigating the mutations in Mycobacterium tuberculosis responsible for resistance to primary anti-TB drugs, specifically isoniazid, and analyzing the resistome of Mycobacterium abscessus, a rapidly growing NTM, isolated from patients in Thailand. The study also seeks to …

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Reproductive Performance Of Gilts And Sows In Gestation Group Housing And Free Farrowing System In Tropical Climate, Natchanon Dumniem Jan 2023

Reproductive Performance Of Gilts And Sows In Gestation Group Housing And Free Farrowing System In Tropical Climate, Natchanon Dumniem

Chulalongkorn University Theses and Dissertations (Chula ETD)

Animal welfare is a rising topic in the swine industry, resulting in the adoption of alternative housing systems. However, the knowledge of management practices to mitigate the deleterious effects of these systems on reproductive performance in tropical environments is limited. This thesis aims to determine the impacts of alternative housing systems on the reproductive performance of sows and gilts, comprising 4 parts. i) To compare reproductive performance among conventional crates (CC), group housing gestation pen with temporary farrowing crate (PC), and group housing gestation pen and free-farrowing pen (PP). On average, the farrowing rate of sows in the CC group …

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Analytical Performance Of Progesterone Testing Using Surface Plasmon Field-Enhanced Fluorescence Spectroscopy Technology In Dogs, Pimuk Sungprasit Jan 2023

Analytical Performance Of Progesterone Testing Using Surface Plasmon Field-Enhanced Fluorescence Spectroscopy Technology In Dogs, Pimuk Sungprasit

Chulalongkorn University Theses and Dissertations (Chula ETD)

A new clinical chemistry analyzer using surface plasmon field-enhanced fluorescence spectroscopy (SPFS) has been introduced into veterinary diagnostic laboratories as a point-of-care unit, enabling rapid turnaround times for both diagnosis and follow-up. Consequently, the test results must be accurate, precise, and reliable. This research aims to evaluate the method performance of the analyzer. The evaluation was conducted according to Clinical Laboratory Improvement Amendments (CLIA) guidelines using method validation. The performance evaluation included studies on imprecision (within-day and between-day), method comparison, recovery tests, and linearity for determining progesterone concentration. The method validation results showed good and acceptable precision. Serum spiking concentrations …

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Metagenomic Analysis Using Oxford Nanopore For Fungal Identification In Hemoculture Sample, Nattapong Langsiri Jan 2023

Metagenomic Analysis Using Oxford Nanopore For Fungal Identification In Hemoculture Sample, Nattapong Langsiri

Chulalongkorn University Theses and Dissertations (Chula ETD)

Currently, with advancements in medical technology, the mortality rate from fungal infections has also increased, particularly since the late 20th century. The incidence of invasive fungal infections, especially bloodstream fungal infections, is rising. However, laboratory diagnosis of fungi from clinical specimens still faces significant limitations. Diagnosing fungi based on morphological characteristics to identify species level can take weeks, which is not aligned with the severity of the disease. Current molecular biology techniques also have limitations, such as PCR success rates and mixed infections. With significant advancements in sequencing technology leading to third-generation sequencing, there are notable benefits. Third-generation sequencing, or …

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การพัฒนาตัวชี้วัดเพื่อประเมินคุณภาพพื้นที่สีเขียวในประเทศไทย, ธนโชค วานิชผดุงธรรม Jan 2023

การพัฒนาตัวชี้วัดเพื่อประเมินคุณภาพพื้นที่สีเขียวในประเทศไทย, ธนโชค วานิชผดุงธรรม

Chulalongkorn University Theses and Dissertations (Chula ETD)

การศึกษาในครั้งนี้มีวัตถุประสงค์เพื่อพัฒนาตัวชี้วัดสำหรับประเมินคุณภาพพื้นที่สีเขียวและทดสอบประสิทธิภาพการใช้งาน การศึกษาทำโดย 1) กำหนดวัตถุประสงค์การใช้งานตัวชี้วัดและผู้ที่มีส่วนเกี่ยวข้อง, 2) รวบรวมตัวชี้วัดที่เกี่ยวข้อง, 3) วิเคราะห์และเลือกตัวชี้วัดที่เหมาะสม, 4) จัดทำเป็นแบบประเมิน และ 5) ทดสอบกับพื้นที่สีเขียวตัวอย่างจำนวน 15 แห่ง ได้แก่ ป่าธรรมชาติ/ป่าชุมชน 3 แห่ง สวนสาธารณะ 4 แห่ง พื้นที่ส่วนบุคคล 5 แห่ง และหลังคาเขียว 3 แห่ง ผลการศึกษาได้ตัวชี้วัดคุณภาพพื้นที่สีเขียวแบ่งเป็น 4 ด้าน ได้แก่ สภาพแวดล้อม ความหลากหลายทางชีวภาพ บริการของระบบนิเวศ และการจัดการในพื้นที่ รวม 124 ตัวชี้วัด 370 คะแนน ผลการใช้ตัวชี้วัดพบว่าคะแนนคุณภาพพื้นที่สีเขียวอยู่ในช่วงระหว่าง 296-152 คะแนน ซึ่งเป็นผลจากวัตถุประสงค์การใช้งานและลักษณะพื้นที่ที่มีความหลากหลาย คะแนนแต่ละด้านของพื้นที่สีเขียวแต่ละประเภทส่วนใหญ่มีความสัมพันธ์กับลักษณะพื้นที่ การดูแลและการใช้งานของมนุษย์ ในส่วนของการใช้งานพบว่าผู้ใช้งานมีความพึงพอใจแบบประเมินที่สร้างขึ้นโดยภาพรวมในระดับปานกลางถึงดี (3.73 ± 1.08 คะแนน) โดยเป็นผลจากการออกแบบการประเมินในรูปแบบรวดเร็ว มีการอำนวยความสะดวกในการบันทึกข้อมูลในโปรแกรม Microsoft Excel ใช้เวลาและกำลังคนในการประเมินต่ำ แต่แบบประเมินยังต้องพัฒนาคำอธิบายรายละเอียดและขั้นตอนใช้งานรวมถึงเกณฑ์การให้คะแนนเพิ่มเติม นอกจากนี้ ควรเพิ่มจำนวนพื้นที่สีเขียวที่ประเมินให้มากขึ้นเพื่อทดสอบและปรับปรุงประสิทธิภาพตัวชี้วัด ตลอดจนส่งเสริมให้ผู้มีส่วนเกี่ยวข้องกลุ่มต่าง ๆ นำไปใช้ประโยชน์เพื่อพัฒนาคุณภาพพื้นที่สีเขียวของประเทศต่อไป

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Genetic Diversity Of Influenza A Viruses In Live Bird Markets And Free-Grazing Ducks In Thailand, Supanat Boonyapisitsopa Jan 2023

Genetic Diversity Of Influenza A Viruses In Live Bird Markets And Free-Grazing Ducks In Thailand, Supanat Boonyapisitsopa

Chulalongkorn University Theses and Dissertations (Chula ETD)

Influenza A viruses (IAVs) can infect birds and a wide variety of mammals. Live bird markets (LBMs) and free-grazing ducks (FGDs) are the important reservoirs of influenza A viruses in Thailand. This study aims to gain the overall information of IAVs circulated in LBMs in Bangkok and in FGD flocks in Thailand. IAVs surveillance in LBM in Bangkok was conducted to identified the IAVs in LBM during 2019-2020. The IAV-H9N2 (n=8) and IAV-H9Nx (n=2) were isolated from 1,178 swab samples. The IAVs of the previous CU-EIDAs’ LBM surveillance programs during 2014-2018 were included for overall genetic analysis. Total 6 subtypes …

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Molecular Investigation And Genetic Characterization Of Canine Astrovirus And Canine Kobuvirus With Associated Pathology In Domestic Dogs In Vietnam And Thailand, Tin Van Nguyen Jan 2023

Molecular Investigation And Genetic Characterization Of Canine Astrovirus And Canine Kobuvirus With Associated Pathology In Domestic Dogs In Vietnam And Thailand, Tin Van Nguyen

Chulalongkorn University Theses and Dissertations (Chula ETD)

Canine astrovirus (CaAstV) and canine kobuvirus (CaKoV) are recently recognized pathogens associated with canine gastrointestinal disease (GID), though their exact role remains poorly understood. In both Vietnam and Thailand, these viruses were detected in dogs with and without diarrhea, particularly high frequency in puppies under 6 months old. Co-infection between CaAstV and CaKoV, as well as with other common canine enteric viruses (canine parvovirus, canine enteric coronavirus, canine distemper virus), were also confirmed. Complete coding sequences (CDS) of 7 CaAstV strains and 9 CaKoV strains from Vietnam, and 2 CaAstV strains and 4 CaKoV strains from Thailand were successfully identified. …

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Innovation Of Alpha-Mangostin Encapsulated With Nanostructured-Lipid Carrier As Non-Surgical Castration In Cats And Survey Attitude Towards Surgical Sterilization In Thailand, Shanaporn Leelakajornkit Jan 2023

Innovation Of Alpha-Mangostin Encapsulated With Nanostructured-Lipid Carrier As Non-Surgical Castration In Cats And Survey Attitude Towards Surgical Sterilization In Thailand, Shanaporn Leelakajornkit

Chulalongkorn University Theses and Dissertations (Chula ETD)

Overpopulation of companion animals, particularly dogs and cats, is a global concern, necessitating effective population control policies. This research investigates the attitudes of veterinarians and pet owners in Thailand regarding dog and cat surgical sterilization and the use of progestins as non-surgical contraception. The study also assesses the effects of intratesticular administration of alpha-mangostin encapsulated in nanostructured lipid carriers (AM-NLC) in male cats, and adverse effects. Furthermore, a novel formulation of AM-NLC for intratesticular administration is also developed. Surveys reveal that decisions on sterilization are influenced by species, sex, COVID-19 impacts, and demographic factors. And anesthesia risks remain a primary …

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Developmental Model Of Endometrial Cell Culture For The Study Of Equine Endometrosis, Sawita Santiviparat Jan 2023

Developmental Model Of Endometrial Cell Culture For The Study Of Equine Endometrosis, Sawita Santiviparat

Chulalongkorn University Theses and Dissertations (Chula ETD)

The importance and rationale of this thesis were to address the critical knowledge gap in equine endometrosis by developing a comprehensive 3-dimensional (3D) in vitro model of equine endometrial tissue using advanced technology like 3D bioprinting. Study 1 aimed to develop an in vitro model for studying equine endometrial function by isolating and characterizing equine endometrial epithelial cells (eECs) and endometrial mesenchymal stem cells (eMSCs) using a modified tissue explantation outgrowth technique. Both cell types were successfully cultured in specific medium conditions, maintaining their characteristic features. Notably, eECs retained their function in fetal bovine serum (FBS) and KnockOut™ serum replacement …

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Value-Added Natural Fiber As A Biocompatible Substrate For Chemical Sensor Applications, Wisarttra Phamonpon Jan 2023

Value-Added Natural Fiber As A Biocompatible Substrate For Chemical Sensor Applications, Wisarttra Phamonpon

Chulalongkorn University Theses and Dissertations (Chula ETD)

This dissertation focuses on the improvement and value added of natural fiber extracted from the UHT milk carton waste, and raw silk cocoon to fabricate the biocompatible substrate for chemical sensors, principally in colorimetric and electrochemical sensors, which is allocated in 3 main parts. Initially, the background studying of the surface modification and the function of natural fiber based chemical sensor for food quality control and clinical diagnosis will be explained in a review article. Subsequently, the development of recycled cellulose from UHT milk carton waste as a novel substrate of dual lactate sensor for milk spoilage indication will be …

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