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การเปรียบเทียบประสิทธิภาพของวิธีการสร้างช่วงความเชื่อมั่นสำหรับสัมประสิทธิ์การถดถอยลอจิสติกในข้อมูลที่มีมิติสูง โดยใช้การประมาณสองขั้นตอนด้วยวิธี Lasso + Mle And A Bootstrap Lasso + Partial Ridge, ณิชากร ไทยวงษ์ Jan 2021

การเปรียบเทียบประสิทธิภาพของวิธีการสร้างช่วงความเชื่อมั่นสำหรับสัมประสิทธิ์การถดถอยลอจิสติกในข้อมูลที่มีมิติสูง โดยใช้การประมาณสองขั้นตอนด้วยวิธี Lasso + Mle And A Bootstrap Lasso + Partial Ridge, ณิชากร ไทยวงษ์

Chulalongkorn University Theses and Dissertations (Chula ETD)

งานวิจัยนี้มีวัตถุประสงค์เพื่อเปรียบเทียบวิธีการสร้างช่วงความเชื่อมั่นสำหรับสัมประสิทธิ์การถดถอยลอจิสติกในข้อมูลที่มีมิติสูง โดยใช้การประมาณสองขั้นตอนด้วยวิธี Lasso+MLE และวิธี Lasso+ Partial Ridge ซึ่งในการศึกษานี้จะจำลองข้อมูลทั้งหมด 8 ชุด และเปรียบเทียบประสิทธิภาพของช่วงความเชื่อมั่นที่ได้จากการสร้างช่วงความเชื่อมั่นทั้งหมด 4 วิธี ได้แก่ วิธี Parametric Bootstrap Lasso+MLE, วิธี Parametric Bootstrap Lasso+Partial Ridge, วิธี Paired Bootstrap Lasso+MLE และวิธี Paired Bootstrap Lasso+Partial Ridge โดยใช้เกณฑ์ในการเปรียบเทียบประสิทธิภาพของช่วงความเชื่อมั่น คือ ความกว้างเฉลี่ยของช่วงความเชื่อมั่น ค่าความน่าจะเป็นครอบคลุม ค่าความแม่นยำ และค่าความไว จากการศึกษาภายใต้ขอบเขตดังกล่าวผลปรากฏว่า วิธี Parametric Bootstrap Lasso+Partial Ridge มีประสิทธิภาพในการสร้างช่วงความเชื่อมั่นมากที่สุด รองลงมาคือ วิธี Paired Bootstrap Lasso+Partial Ridge และวิธี Paired Bootstrap Lasso+MLE ตามลำดับ และวิธีที่มีประสิทธิภาพในการสร้างช่วงความเชื่อมั่นน้อยที่สุด ก็คือ วิธี Parametric Bootstrap Lasso+MLE ดังนั้นจึงสรุปได้ว่า การสร้างช่วงความเชื่อมั่นสำหรับสัมประสิทธิ์การถดถอยลอจิสติกโดยใช้การประมาณสองขั้นตอนด้วยวิธี Lasso+Partial Ridge มีประสิทธิภาพมากกว่าวิธี Lasso+MLE

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การวิเคราะห์ข้อมูลด้วยภาพเพื่อการจัดซื้อหนังสือด้วยข้อมูลบรรณานุกรมของสำนักงานวิทยทรัพยากร จุฬาลงกรณ์มหาวิทยาลัย, ธนศาสตร์ ทักษิณ Jan 2021

การวิเคราะห์ข้อมูลด้วยภาพเพื่อการจัดซื้อหนังสือด้วยข้อมูลบรรณานุกรมของสำนักงานวิทยทรัพยากร จุฬาลงกรณ์มหาวิทยาลัย, ธนศาสตร์ ทักษิณ

Chulalongkorn University Theses and Dissertations (Chula ETD)

ปัจจุบันการจัดซื้อหนังสือของสำนักงานวิทยทรัพยากร จุฬาลงกรณ์มหาวิทยาลัยจะจัดซื้อตามคำแนะนำของผู้ใช้งานและประสบการณ์ของบรรณารักษ์ โดยส่วนมากจะจัดซื้อหนังสือที่สอดคล้องกับหลักสูตรการเรียนการสอนซึ่งยังไม่ตรงตามความต้องการของผู้ใช้งาน การวิจัยนี้เป็นการเปรียบเทียบประสิทธิภาพการจัดซื้อหนังสือก่อนและหลังการใช้โปรแกรมเพื่อตัดสินใจซื้อ ซึ่งสามารถวางแผนการจัดซื้อหนังสือได้อย่างมีประสิทธิภาพ โดยแสดงภาพปริมาณและราคาที่เหมาะสมของหนังสือแต่ละเล่มที่ตรงกับความต้องการของผู้ใช้จริง ผู้วิจัยได้คัดเลือกบรรณารักษ์ของสำนักงานวิทยทรัพยากรฯ แบบเจาะจงในการทําวิจัยและศึกษาความต้องการของผู้ใช้งานในการซื้อหนังสือของสำนักงานวิทยทรัพยากรฯ และพัฒนาโปรแกรมการแนะนำหนังสือโดยให้บรรณารักษ์เป็นผู้ทดสอบคุณภาพโปรแกรม การทดสอบใช้ข้อมูลหนังสือจากสำนักงานวิทยทรัพยากรฯ ที่ตีพิมพ์ในช่วงปี ค.ศ. 2010-2019 โดยใช้ค่าดัชนีแจ็คการ์ดวัดประสิทธิภาพการแนะนำหนังสือของโปรแกรมซึ่งคือค่าความคล้ายคลึงของการเลือกหนังสือก่อนและหลังใช้ภาพแสดงข้อมูลจากโปรแกรมในสถานการณ์ต่าง ๆ 8 สถานการณ์ ผลการทดสอบคือบรรณารักษ์สามารถเลือกหนังสือคล้ายคลึงกับภาพที่โปรแกรมแนะนำคือการใช้ภาพแสดงข้อมูลสามารถบอกข้อดีและข้อเสียของการเลือกซื้อหนังสือด้วยวิธีปัจจุบันและสามารถแนะนำเงื่อนไขเพิ่มเติมเพื่อให้วิธีการเลือกซื้อหนังสือในปัจจุบันมีประสิทธิภาพมากขึ้น

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Epidemiology, Molecular Genetic, And Evolutionary Analysis Of Humanrotavirus A Infection In Thailand, Fajar Budi Lestari Jan 2021

Epidemiology, Molecular Genetic, And Evolutionary Analysis Of Humanrotavirus A Infection In Thailand, Fajar Budi Lestari

Chulalongkorn University Theses and Dissertations (Chula ETD)

Rotavirus A (RVA) infection remains one of the major causes of viral diarrhea in young children worldwide. Despite the success of RVA vaccines including RotaTeq in significantly reducing morbidity and disease severity associated with hospitalization, national immunization against RVA have only just begun in Thailand in 2020. Consequently, possible RV vaccine shedding among pediatric vaccine recipients has not been rigorously documented here.The first part of my study was summarize the virology, disease burden, prevalence, distribution of genotypes and seasonality of RVs, and the current status of RV vaccination in Southeast Asia (Cambodia, Indonesia, Lao People’s Democratic Republic, Malaysia, Myanmar, Philippines, …

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Use Of Polyacrylonitrile As Anodic Artificial Solid Electrolyte Interphase For Aqueous-Based Zinc-Ion Batteries, Nutchaya Muangplod Jan 2021

Use Of Polyacrylonitrile As Anodic Artificial Solid Electrolyte Interphase For Aqueous-Based Zinc-Ion Batteries, Nutchaya Muangplod

Chulalongkorn University Theses and Dissertations (Chula ETD)

Rechargeable aqueous zinc-ion batteries (ZIBs) have attracted attention for energy storage systems because of their high specific capacity, low cost, and safety. However, practical application of the zinc anode in mild acidic electrolytes is limited by several issues such as dendrite formation, corrosion, hydrogen evolution reaction, passivation and relatively low cycling performance. Coating the zinc anode with graphite (GP) (GP@Zn) can partially solve these issues and improves the cycling performance of ZIB. However, after long-term charge/discharge cycles, zinc tends to migrate and redeposit over the surface of GP owing to the electronic conductivity of GP particles. Thus, after long-term cycling, …

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Synthesis Of Baicalein Derivatives As Anti-Dengue Agents, Apinya Patigo Jan 2021

Synthesis Of Baicalein Derivatives As Anti-Dengue Agents, Apinya Patigo

Chulalongkorn University Theses and Dissertations (Chula ETD)

Dengue, a mosquito-borne viral disease, is now considered a major international health concern, and hence the development of a new anti-dengue drug is highly desirable. Baicalein is a flavone isolated from the roots of Scutellaria baicalensis and Scutellaria lateriflora. Baicalein derivatives have been shown previously to exhibit a promising anti-dengue activity. In this study, five novel and thirteen known baicalein derivatives were synthesized via semi synthesis from baicalein with modifications at C-5, -6, -7, and -8 positions on ring A and a six-step total synthesis with modifications at the para position on the ring B with a range of electron-withdrawing …

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Performance Improvement Of Cms Simulation Via Loop Transformation, Teerit Ploensin Jan 2021

Performance Improvement Of Cms Simulation Via Loop Transformation, Teerit Ploensin

Chulalongkorn University Theses and Dissertations (Chula ETD)

High performance processor can tackle bottleneck issues by increasing vector lengths and leveling effectiveness of memory hierarchies to address these issue. Manual optimization of code is a difficult task when having multiple architecturedependent transformation. Our goal is to develop a tool that performs source code transformation based on loop optimization techniques, since a loop plays an important role in improving of performance in scientific simulation software. We implement an source-to-source transformation tool based libTooling, a Clang’s library, based on polyhedral model to simplify a loop transformation of CMSSW building pipeline. The tool also can be used for automatically transformation. The …

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Sentiment Analysis Of Messages On Twitter Related To Covid-19 Using Deep Learning Approach, Chotika Imvimol Jan 2021

Sentiment Analysis Of Messages On Twitter Related To Covid-19 Using Deep Learning Approach, Chotika Imvimol

Chulalongkorn University Theses and Dissertations (Chula ETD)

The widespread situation of the Coronavirus-19 (COVID-19) pandemic is a tangible and pressing concern. Many changes in terms of lifestyle are necessary to reduce the chance of infection. While citizens have gone through different emotions, they share their thoughts and interactions on social media, especially on Twitter. COVID-19 related messages can imply social emotion. This study performs sentiment analysis on tweets and annotated them into six classes of positive and negative feelings consisting of anger, disgust, fear, sadness, joy, and surprise. We analyzed both textual information and historical data. We collected 120,642 unique tweets datasets between 1 January 2020 and …

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A Deep Learning Model For Predicting Long Non-Coding Rna And Messenger Rna With Model Interpretation, Rattaphon Lin Jan 2021

A Deep Learning Model For Predicting Long Non-Coding Rna And Messenger Rna With Model Interpretation, Rattaphon Lin

Chulalongkorn University Theses and Dissertations (Chula ETD)

Long non-coding RNAs (lncRNAs) play important roles in many biological processes and are found to be associated with several diseases. The development of next-generation sequencing technologies has discovered numerous unannotated transcripts. However, classifying these unannotated transcripts by using biological experiments is very time-consuming and expensive. Thus, a computational approach is considered as an alternative solution which is faster and cheaper. Many existing lncRNA identification tools are available, these tools lack an explanation of which features contributed to their prediction results. Here, we present Xlnc1DCNN, a tool for distinguishing long non-coding RNAs (lncRNAs) from protein-coding transcripts (PCTs) together with a prediction …

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Precise Extratemporal Pattern And Intramuscular Distribution Of The Facial Nerve, Sukanya Uruwan Jan 2021

Precise Extratemporal Pattern And Intramuscular Distribution Of The Facial Nerve, Sukanya Uruwan

Chulalongkorn University Theses and Dissertations (Chula ETD)

An arborization of the branches of the facial nerve has the most complexity and variability. Moreover, knowledge of the facial nerve has great importance for surgical and non-surgical interventions in the face region. However, few studies have attempted to determine the entire course and pattern of terminal branching of the facial nerve in the extratemporal and intramuscular parts of the face. Therefore, the purpose of this study was to investigate the precise detail of the facial nerve in extratemporal and intramuscular parts. This study was conducted in forty-two hemifaces of embalmed cadavers by conventional dissection, fourteen hemi-faces of embalmed cadavers …

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Attenuation Of Chronic Kidney Disease (Ckd) And Uremia Induced Gut-Leakage By Lactobacillus Rhamnosus L34, A Probiotic Derived From Thai Population, In 5/6 Nephrectomy Model Mice; An Experimental Study, Somkanya Tungsanga Jan 2021

Attenuation Of Chronic Kidney Disease (Ckd) And Uremia Induced Gut-Leakage By Lactobacillus Rhamnosus L34, A Probiotic Derived From Thai Population, In 5/6 Nephrectomy Model Mice; An Experimental Study, Somkanya Tungsanga

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Although pathogenic gut microbiota causes gut leakage, increases translocation of uremic toxins into circulation, and accelerates CKD progression, the local strain of Lactobacillus rhamnosus L34 (L34) might attenuate gut leakage. We explored the effects of L34 on kidney fibrosis and levels of gut-derived uremic toxins (GDUTs) in 5/6-nephrectomy (5/6 Nx) mice. Methods: At 6 weeks post-5/6 Nx in mice, either L34 (1x106 CFU) or phosphate buffer solution (as 5/6 Nx control) were daily fed for 14 weeks. In vitro, the effects of L34-conditioned media with or without indoxyl sulfate (a representative GDUT) on inflammation and cell integrity (transepithelial electrical …

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Effect Of Dielectric Barrier Discharge Plasma Hydrogenation On Oxidation Stability Of Biodiesel Derived From Vegetable Oils, Grittima Kongprawes Jan 2021

Effect Of Dielectric Barrier Discharge Plasma Hydrogenation On Oxidation Stability Of Biodiesel Derived From Vegetable Oils, Grittima Kongprawes

Chulalongkorn University Theses and Dissertations (Chula ETD)

A parallel-plate type dielectric barrier discharge (DBD) plasma was utilized to produce partially hydrogenated fatty acids methyl ester (PH-FAME) derived from soybean and palm FAME. PH-FAME exhibits improved oxidation resistance, resulting in a longer storage time and a delay in changing fuel properties. The DBD plasma reaction occurred at atmospheric pressure and ambient temperature without a catalyst. The best condition for 35 mL of soybean FAME hydrogenation was using 25% H2 at ambient temperature for 5.5 h. An increase in saturated and monounsaturated FAMEs corresponded to a reduction of iodine value from 128 to 67.4. This condition created trans fatty …

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A Retrospective Study In Comparison Of Skeletal Stability And Pharyngeal Airway Changes In Mandibular Prognathism After Correction With Mandibular Setback Surgery Using Two Different Types Of Osteofixation Materials, Phu Hnin Thet Jan 2021

A Retrospective Study In Comparison Of Skeletal Stability And Pharyngeal Airway Changes In Mandibular Prognathism After Correction With Mandibular Setback Surgery Using Two Different Types Of Osteofixation Materials, Phu Hnin Thet

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: This study compared the skeletal stability and pharyngeal airway changes after mandibular setback procedure using the titanium and resorbable plate and screws fixation. Materials and Methods: 28 patients with mandibular prognathism being treated with bilateral sagittal split ramus osteotomy (BSSRO) were randomly selected from titanium and resorbable fixations. Analyses of lateral cephalometric x-rays were performed according to preoperative (T0), 1st week post-surgery (T1), 3-6 months post-surgery (T2) and 1-year post-surgery (T3). The horizontal measurement (BX), vertical measurement (BY), and angle measurement (SNB and Mandibular Plane Angle; MPA) were studied for skeletal stability. The pharyngeal airway changes were observed by …

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Effect Of Shear Force On Immunosuppressive Property Of Human Periodontal Ligament Cells, Ravipha Suwittayarak Jan 2021

Effect Of Shear Force On Immunosuppressive Property Of Human Periodontal Ligament Cells, Ravipha Suwittayarak

Chulalongkorn University Theses and Dissertations (Chula ETD)

The immunomodulatory property is to regulate immune cell function. IDO and TGF-β1 inhibited T cell proliferation and induced regulatory T (Treg) cells differentiation. However, this property must be activated by inflammation. Recently, mechanical forces have also activated this property. Hence, this study investigated effect of shear stress on immunosuppressive property of hPDL cells. Cells were subjected to shear stress then expression of IDO, TGF-β1, IFN-gamma and COX2 mRNA and protein was examined by qRT-PCR, ELISA, and IDO activity. Conditioned media derived shear stress were treated with CD4+ T cells. The proliferative T cell effect was determined using resazurin. The FOXP3, …

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Expression Of Vascular Endothelial Growth Factor Protein In Mrna-Transfected Human Periodontal Ligament Cells, Mana Naratippakorn Jan 2021

Expression Of Vascular Endothelial Growth Factor Protein In Mrna-Transfected Human Periodontal Ligament Cells, Mana Naratippakorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

The complete regeneration of periodontal tissues following current periodontal therapy remain challenging and unpredictable. Nucleoside-modified messenger RNA (mRNA) technology can be a promising novel platform in regenerative medicine. The aims of this study were to evaluate whether pseudouridine modified mRNA encoding vascular endothelial growth factor (VEGF) could induce VEGF production in human periodontal ligament cells (PDLCs) and this translated protein function by promoting in vivo blood vessel formation using chorioallantoic membrane (CAM) assay. Isolated PDLCs from healthy periodontal tissue were transfected with modified mRNA encoding VEGF (VEGF mRNA) complexed with a transfecting agent, Lipofectamine 2000 (L2000) and L2000 alone (control). …

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Effects Of Local Versus Systemic Administration Of Cxcr4 Inhibitor Amd3100 On Orthodontic Tooth Movement In Rats, Narubhorn Ongprakobkul Jan 2021

Effects Of Local Versus Systemic Administration Of Cxcr4 Inhibitor Amd3100 On Orthodontic Tooth Movement In Rats, Narubhorn Ongprakobkul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Chemokines play pivotal roles in orthodontic tooth movement (OTM) through osteoclast-mediated bone resorption, but the underlying mechanism remains unclear. We aimed to elucidate the effects of serial local vs systemic administration of the chemokine receptor CXCR4 antagonist AMD3100 on OTM. The maxillary right first molar (M1) of rats was moved mesially using a 10 g of force nickel-titanium coil spring. The injections were performed every other day with phosphate-buffered saline as a control, whereas local and systemic animals were injected with AMD3100 at the buccal palatal mucosa adjacent to M1 and subcutaneously, respectively. OTM distance and alveolar bone were examined …

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Clinical Efficacy Of Silk Sericin Dressing With Collagen For Split-Thickness Skin Graft Donor Site Treatment, Apirujee Punjataewakupt Jan 2021

Clinical Efficacy Of Silk Sericin Dressing With Collagen For Split-Thickness Skin Graft Donor Site Treatment, Apirujee Punjataewakupt

Chulalongkorn University Theses and Dissertations (Chula ETD)

Sericin dressing containing collagen hydrolysate (SDC) was evaluated in this study, consisting of two phases of clinical trials. The clinical safety of SDC was determined using a patch test in 103 healthy volunteers (phase I). Most of the results (around 90%) in the SDC group were interpreted as negative and doubtful reactions, and the remaining results (around 10%) were weak reactions. After that, the clinical efficacy and safety of SDC were investigated in 21 patients with 30 split-thickness skin graft (STSG) donor sites (phase II). Each donor site was divided into two equal sites. SDC or the commercial dressing (Bactigras®) …

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Antioxidant With Antimelanogenic Activities Of Sericin Hydrolysates Optimized By Response Surface Methodology In Human Melanin-Generating Mnt-1 Cells, Keerati Joyjamras Jan 2021

Antioxidant With Antimelanogenic Activities Of Sericin Hydrolysates Optimized By Response Surface Methodology In Human Melanin-Generating Mnt-1 Cells, Keerati Joyjamras

Chulalongkorn University Theses and Dissertations (Chula ETD)

Sericin, a protein presenting in the wastewater from silk industry, causes water pollution and ecological problem. To increase economic value to this waste product, the optimum enzymatic condition that could create sericin hydrolysates with high antioxidant and antimelanogenic capacities was generated through response surface methodology (RSM). Response surface plots demonstrate the major role of temperature on scavenging capacity of sericin hydrolysates assessed via DPPH, FRAP and ORAC assays. Alcalase®-hydrolyzed sericin consisted of sericin-related peptides in differing amounts and smaller sizes compared with unhydrolyzed sericin, as respectively demonstrated by peptidomic and SDS-PAGE analysis. Pre-incubation with 20 mg/mL sericin hydrolysates digested by …

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Development Of Mucoadhesive Polymeric Nanoparticles For Intranasal Delivery Of Favipiravir In Treating Sars-Cov-2 Infection, Khent Alcantara Jan 2021

Development Of Mucoadhesive Polymeric Nanoparticles For Intranasal Delivery Of Favipiravir In Treating Sars-Cov-2 Infection, Khent Alcantara

Chulalongkorn University Theses and Dissertations (Chula ETD)

Nanoparticles (NPs) have been used as an effective carrier for transmucosal delivery of drugs through their prolonged residence time and deposition, or the enhanced permeation through the mucosa. In this study, we aimed to design a nanocarrier using the combined mucoadhesive (M) properties of chitosan (CS) and alginate (ALG) polymers for the intranasal delivery of favipiravir (FVR) in treating SARS-CoV-2 infection. The optimized FVR-loaded mucoadhesive CS-coated ALG-NPs (FVR-MCS-ALG-NPs) rendered suitable size (233.5 nm), zeta potential (-21.6 mV), loading capacity (26.0%), and encapsulation efficiency (84.6%) for transmucosal delivery. Superior mucoadhesiveness and higher permeation and deposition in the porcine nasal mucosa of …

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Development Of Plant-Produced Subunit Vaccine And Therapeutic Protein For Covid-19, Konlavat Siriwattananon Jan 2021

Development Of Plant-Produced Subunit Vaccine And Therapeutic Protein For Covid-19, Konlavat Siriwattananon

Chulalongkorn University Theses and Dissertations (Chula ETD)

Due to the rapid transmission of the Coronavirus Disease 2019 (COVID-19) causing serious public health problems and economic burden, the development of effective therapeutic interventions is urgently needed for controlling the ongoing pandemic disease. In this study, we have transiently produced recombinant SARS-CoV-2 RBD and human ACE2 fused with the Fc region of human IgG1 in Nicotiana benthamianain in order to use as a preventive subunit vaccine and therapeutic against SARS-CoV-2. The recombinant SARS-CoV-2 RBD-Fc subunit vaccine was formulated with different commercially available adjuvants including aluminium hydroxide gel (Alum), AddaVaxTM (MF59), monophosphoryl lipid A from Salmonella Minnesota R595 (mPLA-SM), and …

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Effect Of Hydroquinone 5-O-Cinnamoyl Ester Of Renieramycin M On The Suppression Of Lung Cancer Stem Cells, Nattamon Hongwiangchan Jan 2021

Effect Of Hydroquinone 5-O-Cinnamoyl Ester Of Renieramycin M On The Suppression Of Lung Cancer Stem Cells, Nattamon Hongwiangchan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Cancer stem cells (CSCs) are distinct cancer populations with tumorigenic and self-renewal abilities. CSCs are drivers of cancer initiation, progression, therapeutic failure, and disease recurrence. Thereby, novel compounds targeting CSCs offer a promising way to control cancer. In this study, the hydroquinone 5-O-cinnamoyl ester of renieramycin M (CIN-RM) was demonstrated to suppress lung cancer CSCs. CIN-RM was toxic to lung cancer cells with a half-maximal inhibitory concentration around 15 µM. CIN-RM suppressed CSCs by inhibiting colony and tumor spheroid formation. In addition, the CSC population was isolated and treated and the CSCs were dispatched in response to CIN-RM within 24 …

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Anti-Addictive Activity Of Quinuclidine Derivatives In Nicotine-Induced Conditioned Place Preference Test In Mice, Saranda Nianpanich Jan 2021

Anti-Addictive Activity Of Quinuclidine Derivatives In Nicotine-Induced Conditioned Place Preference Test In Mice, Saranda Nianpanich

Chulalongkorn University Theses and Dissertations (Chula ETD)

Quinuclidine derivatives (s)-T1, (s)-T2, and (s)-T6 are the ligands of α3β4 nicotinic acetylcholine receptor (nAChR). α3β4 nAChRs are highly expressed in medial habenula (MHb). The MHb connects to the brain rewarding pathway and mediates nicotine induce rewarding effect. Various α3β4 nicotinic acetylcholine antagonists have been investigated for their anti-addictive effect in animal models of nicotine addiction. The present study was aimed to evaluate the anti-addictive effects and mechanisms of quinuclidine derivatives, (s)-T1, (s)-T2, and (s)-T6 in nicotine-induced conditioned place preference (CPP) in mice. In the first experiment, mice received either nicotine (0.5 mg/kg, s.c.), (s)-T1 (1, 3, or 10 mg/kg, …

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Performance Of Memory Function Based On Naturalistic Data, Chanin Kumpeerakij Jan 2021

Performance Of Memory Function Based On Naturalistic Data, Chanin Kumpeerakij

Chulalongkorn University Theses and Dissertations (Chula ETD)

Nonlinear dynamical systems, such as well-tuned recurrent neural networks, have proved a powerful tool for modeling temporal data. However, tuning such models to achieve the best performance remains an outstanding challenge, not least because of the complex behaviors that emerge from interacting microscopic constituents. Here, we consider a minimal model of two interacting phase oscillators coupled to a thermal bath and driven by a common signal. We quantify the memory and predictive capability of the system with the mutual information between the phases of oscillators and the signals at different times. We show that the interaction and heterogeneity between oscillators …

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Design And Fabrication Of Perovskite Solar Cells For Tandem Structures, Kwanruthai Butsriruk Jan 2021

Design And Fabrication Of Perovskite Solar Cells For Tandem Structures, Kwanruthai Butsriruk

Chulalongkorn University Theses and Dissertations (Chula ETD)

In this thesis, fabrication processes for making perovskite solar cells (PSCs) suitable for tandem structures are described. We find that different conditions of fabrication significantly affect the perovskite absorber film properties and power conversion efficiency (PCE) of PSCs. To achieve the best quality, perovskite absorber films were prepared by two-step spin coating from PbI2 and CH3NH3I (MAI) precursors, and solar cell yielded a maximum PCE of 17.2% and 15.4% for a normal and an inverted PSCs, respectively. These PSCs can be applied to the design and fabrication of tandem solar cells (TSCs) that consist of PSCs as a top subcell …

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Effects Of Low Degree Of High Ambient Temperature On Neural Pathways From Median Preoptic Nucleus To Arcuate Nucleus In Related To Food Intake., Pornsiri Suwannapaporn Jan 2021

Effects Of Low Degree Of High Ambient Temperature On Neural Pathways From Median Preoptic Nucleus To Arcuate Nucleus In Related To Food Intake., Pornsiri Suwannapaporn

Chulalongkorn University Theses and Dissertations (Chula ETD)

High ambient temperature (HTa) is one important environmental factor that decreases food intake (FI). It is well accepted that high degree HTa induced heat stress decreased FI by the activation of corticotropin-releasing factor (CRF) via hypothalamic pituitary adrenal axis. However, short-term low-degree HTa exposure has been demonstrated to decrease FI earlier than activated physiological and stress responses. This effect was related to the neuronal connection between the median preoptic nucleus (MnPO) and arcuate nucleus (Arc). Therefore, the present study aimed to investigate the effect of short-term low-degree HTa exposure on the activity of hypothalamic Arc in regarding to FI, and …

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Fear Appeals For Increasing Intentions To Have Colorectal Cancer Screening Among High-Risk Adults: Moderating Role Of Tripartite Self-Construal, Suprapa Sa-Ngasri Jan 2021

Fear Appeals For Increasing Intentions To Have Colorectal Cancer Screening Among High-Risk Adults: Moderating Role Of Tripartite Self-Construal, Suprapa Sa-Ngasri

Chulalongkorn University Theses and Dissertations (Chula ETD)

Colorectal cancer (CRC) is considered a threat to life. Early detection is key to effective treatment. Fear appeal is one of the most famous techniques to persuade people to uptake CRC screening. This current study attempted to replicate the congruent effect of cultural orientation at an individual level and fear message types. A 3 (self-construal) x 2 (self-threatened versus family-threatened) factorial research design was employed to examine the effect of tripartite self-construal and the types of fear message on the perceived threat, feelings of fear, attitude and intention toward CRC screening among Thais. One hundred and thirty-three adults aged between …

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Outpatient Satisfaction With Community Health Service Center During The Covid-19 Pandemic In Shanghai, People's Republic Of China, Enli Chen Jan 2021

Outpatient Satisfaction With Community Health Service Center During The Covid-19 Pandemic In Shanghai, People's Republic Of China, Enli Chen

Chulalongkorn University Theses and Dissertations (Chula ETD)

Patient satisfaction survey has been highly important, since satisfying the needs and expectations of patients had become a significant strategy for survival in the healthcare business. This study aims (1) to evaluate levels of patient satisfaction using the SERVQUAL in Dapuqiao Community Health Service Center during COVID-19 pandemic, (2) to assess the difference between perceptions and expectations for service dimensions, and (3) to identify the most crucial service items using the importance and performance analysis (IPA), in terms of their need for managerial action to improve outpatient satisfaction. A cross-sectional study was conducted in Dapuqiao Community Health Service Center in …

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Effect Of Line Application On Action And Coping Plans On Exercise Adherence And Functional Performance For Older Adults With Knee Pain In Suburban Area Of Bangkok Metropolis, Thailand : A Quasi Experimental Study, Pattaraporn Piwong Jan 2021

Effect Of Line Application On Action And Coping Plans On Exercise Adherence And Functional Performance For Older Adults With Knee Pain In Suburban Area Of Bangkok Metropolis, Thailand : A Quasi Experimental Study, Pattaraporn Piwong

Chulalongkorn University Theses and Dissertations (Chula ETD)

The known advantage of exercise for older adults who had knee pain is limited by low adherence to an exercise program. LINE application on action and coping plans do improve exercise adherence, knee functional performance and reduce knee pain. This quasi-experimental study determined the effect of LINE application on action and coping plans on exercise adherence, self-efficacy for exercise (SEE) , specific self-efficacy (task, maintenance, recovery), functional performance including knee range of motion (ROM), time up and go (TUG), 30-second chair stand (30CST) , knee outcome for activities of daily living (KOS-ADLS) and knee pain scale among older adults with …

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Association Between Physical Activity And Mental Health Among University Students In Bangladesh : A Cross Sectional Study, Sanjida Sultana Jan 2021

Association Between Physical Activity And Mental Health Among University Students In Bangladesh : A Cross Sectional Study, Sanjida Sultana

Chulalongkorn University Theses and Dissertations (Chula ETD)

Introduction: Mental health is considered one of the most significant topics of public health as it makes up an integral part of a person’s ability to lead a fulfilling life. University students are one of the most vulnerable groups to be affected by mental health disorders due to a change in their life and societal pressure. Lifestyle modifications like physical activity can be one way to combat these Mental Health problems. Although a lot of research has been carried out to analyze the health impact of Physical exercise, impact of it on Mental Health still lags, especially during the Covid-19 …

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Compilation, Explanation And Restoration Of Moh Phon's Herbal Formulations For Skin Conditions, Qiaoling Ye Jan 2021

Compilation, Explanation And Restoration Of Moh Phon's Herbal Formulations For Skin Conditions, Qiaoling Ye

Chulalongkorn University Theses and Dissertations (Chula ETD)

Moh Phon’s traditional Thai medicine formularies were developed, compiled and recorded by Abhakara Kiartivongse or Moh Phon until 1915. This study aimed to elucidate traditional Thai medical wisdom regarding to Moh Phon formularies, especially for skin diseases. Herbal crude drugs in Moh Phon’s traditional Thai medicine formularies for skin diseases were compiled and authenticated for their vernacular and scientific names. The descriptions of plant species, ethnomedical uses, pharmacological activities and active constituents and toxicities were scientifically reviewed and established. The prevalence of plant species used in the formularies was analyzed. The formularies for 26 symptoms or diseases in the skin …

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Effectiveness Of A Pharmacist-Led Expert System For Medication Adherence And Blood Pressure Control Of Adults With Hypertension In The Philippines: A Randomized Controlled Trial, Margarita Gutierrez Jan 2021

Effectiveness Of A Pharmacist-Led Expert System For Medication Adherence And Blood Pressure Control Of Adults With Hypertension In The Philippines: A Randomized Controlled Trial, Margarita Gutierrez

Chulalongkorn University Theses and Dissertations (Chula ETD)

In the Philippines, the Hypertension control rate is only 20% due to low medication adherence. The author proposes an intervention to supplement government program. The aim of the study is to assess the effect on medication adherence and blood pressure control of patients. A randomized control trial was conducted at ten study sites in Region IV-A of the Philippines between May 2021 and January 2022. Outcomes are measured at enrollment as well as at three different time intervals. A total of 417 patients were eligible for the study with 203 in the control group and 214 in the intervention group. …

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