Digital Commons Network^™

Development Of Wiskott-Aldrich Syndrome Knock Out Protocol For Drug Substance Assay Development, Julia C. Hanna

Master's Theses

Wiskott-Aldrich Syndrome (WAS) is a rare X-linked primary immunodeficiency affecting approximately 1 in 100,000 live XY births in North America and is caused by a mutation to the WAS gene which is expressed across hematopoietic lineages. The WAS protein (WASp) plays a role in regulating actin polymerization. On a cellular level, there are a variety of effects of a lack of WASp or expression of a dysfunctional WASp protein for patients including issues with migration, adhesion, chemotactic response, phagocytosis, activation, and proliferation across different cell types in addition to reduced platelet size and output. This can lead to several systematic …

Design Of Class F-Based Doherty Power Amplifier For S-Band Applications, Kyle Chang

Master's Theses

Modern RF and millimeter-wave communication links call for high-efficiency front end systems with high output power and high linearity to meet minimum transmission requirements. Advanced modulation techniques, such as orthogonal frequency-division multiplexing (OFDM) require a large power amplifier (PA) dynamic range due to the high peak-to-average power ratio (PAPR). This thesis provides the analysis, design, and experimental verification of a high-efficiency, high-linearity S-band Doherty power amplifier (DPA) based on the Class F PA. Traditional Class F PAs use harmonically tuned output matching networks to obtain up to 88.4% power-added efficiency (PAE) theoretically, however the amplifier experiences poor linearity performance due …

Deep Learning Recommendations For The Acl2 Interactive Theorem Prover, Robert K. Thompson, Robert K. Thompson

Master's Theses

Due to the difficulty of obtaining formal proofs, there is increasing interest in partially or completely automating proof search in interactive theorem provers. Despite being a theorem prover with an active community and plentiful corpus of 170,000+ theorems, no deep learning system currently exists to help automate theorem proving in ACL2. We have developed a machine learning system that generates recommendations to automatically complete proofs. We show that our system benefits from the copy mechanism introduced in the context of program repair. We make our system directly accessible from within ACL2 and use this interface to evaluate our system in …

Contextually Dynamic Quest Generation Using In-Session Player Information In Mmorpg, Shangwei Lin

Master's Theses

Massively multiplayer online role-playing games (MMORPGs) are one of the most

popular genres in video games that combine massively multiplayer online genres with

role-playing gameplay. MMORPGs’ featured social interaction and forms of level pro-

gression through quest completion are the core for gaining players’ attention. Varied

and challenging quests play an essential part in retaining that attention. However,

well-crafted content takes much longer to develop with human efforts than it does to

consume, and the dominant procedural content generation models for quests suffer

from the drawback of being incompatible with dynamic world changes and the feeling

of repetition over time. …

Estimating The Impact Of Infill Housing On Reduction In Vehicle Miles Traveled, Peyton Marie Ratto

Master's Theses

Vehicle miles traveled (VMT) and its relationship with the built environment has been extensively studied. Most notably, five D variables of the built environment including density, diversity, design, destination accessibility, and distance to transit are the key variables included in this research to explain VMT generation from housing developments. This thesis uses prior research that developed robust statistical models and findings to create a framework to estimate VMT reduction affected by infill housing developed using incentives provided by the state compared to a regional comparator. The regional comparator is typically a suburban single-family housing development in the region. The models …

Development Of A Low-Cost Acoustic Gauge For Simultaneous Tide And Wave Measurement, Alexander Kalman Dunn

Master's Theses

High-quality tide and wave data are essential in a variety of fields including coastal engineering, climate science, disaster response, and recreational activities. Accurate data are publicly accessible from government organizations such as the National Oceanic and Atmospheric Administration (NOAA), however the high costs associated with deploying and maintaining their high accuracy gauges results in a deficit of localized data. Commercial gauges available starting at $2,000 are still expensive for local agencies and individual users to deploy and maintain. These commercial options can also be limited in their scope, accuracy, or ease of use. In this thesis, a low-cost acoustic gauge …

Examining The Use Of A Network Bypass To Circumvent Data Diodes Within Industrial Control Systems, Bryce Molesh

Master's Theses

Our modern world relies upon large scale industrial plants, that are manged by Industrial Control Systems (ICS), to provide critical services such as electricity, water, or waste processing. Over time, these systems have been increasingly connecting outdated systems to modern internet technology to provide additional functionality such as real-time monitoring while also enabling operators to conduct modern business analytics. Thus, these plants offer a potential target for attackers. Recently, such attacks on Industrial Control Systems have increased in number with well publicized attacks such as Stuxnet and TRISIS. To protect against such attacks while also modernizing their networks, Industrial Control …

Constraint-Driven Open-World Scene Generation, Hunter Borlik

Master's Theses

We introduce an alternative method for open-world scene generation. In this thesis, Graph-based Wave Function Collapse (GWFC) is integrated with Space Colonization Algorithm (SCA) and used to place objects in an unstructured 3D environment. This combined algorithm, Space Colonization Graph-based Wave Function Collapse (SC-GWFC), leverages the constraint-based capabilities of GWFC and the ability of SCA to populate arbitrary 3D volumes. We demonstrate that objects of variable scale can be successfully used with SC-GWFC. Since this algorithm is run in an interactive environment, we demonstrate iterative modifications to a partially complete scene and incorporate PCG into a scene editing process. As …

Groups Of Non Positive Curvature And The Word Problem, Zoe Nepsa

Master's Theses

Given a group $\Gamma$ with presentation $\relgroup{\scr{\scr{A}}}{\scr{R}}$, a natural question, known as the word problem, is how does one decide whether or not two words in the free group, $F(\scr{\scr{A}})$, represent the same element in $\Gamma$. In this thesis, we study certain aspects of geometric group theory, especially ideas published by Gromov in the late 1980's. We show there exists a quasi-isometry between the group equipped with the word metric, and the space it acts on. Then, we develop the notion of a CAT(0) space and study groups which act properly and cocompactly by isometries on these spaces, such groups …

An Empirical Evaluation Of Neural Process Meta-Learners For Financial Forecasting, Kevin G. Patel

Master's Theses

Challenges of financial forecasting, such as a dearth of independent samples and non- stationary underlying process, limit the relevance of conventional machine learning towards financial forecasting. Meta-learning approaches alleviate some of these is- sues by allowing the model to generalize across unrelated or loosely related tasks with few observations per task. The neural process family achieves this by con- ditioning forecasts based on a supplied context set at test time. Despite promise, meta-learning approaches remain underutilized in finance. To our knowledge, ours is the first application of neural processes to realized volatility (RV) forecasting and financial forecasting in general.

We …

Documenting Tetranychus Urticae And Lygus Hesperus Resistance Status In California Strawberries, Kiley William Jensen

Master's Theses

The resistance status of Tetranychus urticae Koch and Lygus hesperus Knight sourced from California strawberry fields was evaluated in laboratory bioassay experiments. Adult female T. urticae sourced from a miticide naïve population were exposed to a range of miticide active ingredient concentrations mixed with acetone in contact bioassay experiments. LC₅₀ concentrations for the active ingredients fenpyroximate, abamectin, bifenazate, and spiromesifen as well as LC₉₀ concentrations for the active ingredients fenpyroximate, abamectin, and bifenazate were derived from this susceptible population. A total of ten field populations of T. urticae, five from the Santa Maria growing region and five …

Coupled Boundary Conditions For Modeling Airbreathing Engines, Adam Louis Waldemarson

Master's Theses

Modeling the flight conditions of an aircraft that utilizes an airbreathing propulsion system necessitates a method to account for the increase in energy introduced into the flow. Current methods for modeling engines either assign fixed conditions on flat faces on the intake and exhaust through a manual process with the use of external models or attempt to model the flow through the engine within the simulation using complex and computationally expensive geometry and solvers. The method presented attempts to provide an intermediate option to model airbreathing engines through coupling the intake and exhaust boundary conditions with a parametric engine model. …

​ Soilborne Pathogens Of Strawberry In The Central Coast Region Of California: ​ Survey And Cover Cropping With Wheat For Management Of Macrophomina Phaseolina, Mary Steele

Master's Theses

Surveys of the four major soilborne pathogens of strawberry (Fusarium oxysporum f. sp. fragariae, Macrophomina phaseolina, Phytophthora spp., and Verticillium dahliae) to determine their relative prevalence were conducted in Watsonville-Salinas, CA in 2021 and in Santa Maria, CA in 2022. All four major pathogens were detected at relatively similar prevalence in Watsonville-Salinas, between 22% and 31% of sampled fields. In Santa Maria, M. phaseolina was far more prevalent at 52% of sampled fields, the other three falling between 14% and 17%. Additionally replicated greenhouse and field trials were conducted to evaluate the effects of wheat as …

Assessing The Resilience Of Mycorrhizal Networks Following Central Tree Removal, Deon Lillo

Master's Theses

Mycorrhizal networks (MNs), or the networks of fungal mycelia that connect plants to each other, are vital in contributing to the well-being of ecosystems. They not only assist in the transport of nutrients across an ecosystem, but also help protect an ecosystem from disease and adverse conditions. However, more research into these networks is needed and modelling these networks as graphs can help us achieve this. By applying centrality analysis and performing k-core partitioning on these networks, we are able to identify the trees that are most important and central to a MN and observe the effects of removing these …

Effects Of Concussion And Visuomotor Metrics On Nhl Performance: An Explainable Ai Approach, Michael T. Moschitto

Master's Theses

Cognitive motor integration (CMI), the simultaneous coordination between cerebral function and motor output, is known to deteriorate following a mild traumatic brain injury (mTBI). This thesis explores the relationship between mTBI, CMI, and the performance of elite athletes in the National Hockey League (NHL). The approach focuses on examining the predictive value of various supervised Machine Learning (ML) models with an emphasis on Explainable Artificial Intelligence (XAI) models. Since the ML solution is intended to complement human scouting decisions, we evaluate the experiments based on both interpretability and accuracy on a limited class imbalanced dataset. The contributions of this research …

Reconstructing Identity: Carlton Burgan, Patient Zero In The Development Of Plastic Surgery, Civil War Through World War I, Teresa M. George

Master's Theses

Plastic surgery has played an integral role in helping people achieve societal expectations of appropriate physical appearance since its inception. Through the story of Carlton Burgan, a Union soldier during the American Civil War, who suffered severe facial trauma by mercury poisoning, this thesis hopes to reconstruct the conversation around plastic surgery’s origins as it is influenced by societal standards of the day. Specifically, this thesis argues that the seminal moments leading to plastic surgery being seen as a worthwhile medical specialty was during the Civil War, not World War I as so many scholars have put forth. Violent acts …

The Temporal Evaluation Of Mouthfeel And Retronasal Sensations In Red Wines From The Central Coast Of California, Emily S. Stoffel

Master's Theses

Time-based sensory analysis techniques capture the dynamic retronasal and mouthfeel sensations in wines. It is important to understand how common winemaking practices and popular varietals impact the retronasal and mouthfeel profile as consumers tend to judge wine quality based on the taste, flavor, and mouthfeel of a wine. Three time-based sensory analysis methods were utilized with the objective to understand the effect of five commonly applied winemaking techniques (blending, varietal choice, fermentation temperature, cap management, and stem addition) on the dynamic retronasal and mouthfeel profile of six different varietals (Merlot, Malbec, Petite Sirah, Pinot noir, Grenache, and Tannat) grown on …

Marine Protected Areas And Oceanographic Variability: Impacts On Blue Rockfish (Sebastes Mystinus) And The Human Dimensions Of Collaborative Fisheries Research, Erin M. Johnston

Master's Theses

Fishing pressure and environmental variability are two of the most impactful drivers of fish populations worldwide. It is critical to effective management to understand the intersection between the two and how each may affect fish population dynamics, especially for exploited nearshore species like rockfishes (Sebastes spp.). This is especially true as models indicate that global climate change will dramatically increase the frequency and severity of large-scale oceanographic perturbations. We were interested in whether we could detect changes in relative abundance of nearshore rockfishes relative to large-scale oceanographic events using a broad-scale index like the Multivariate Ocean Climate Indicator …

Programmable Vibration Table Retrofit With Eagle Medical, Jonathan Ilagan, Madhav Asok, Max Lewter

Biomedical Engineering

This project aimed to repair and upgrade a vibration table used for package testing for the sponsor, Eagle Medical - a medical packaging and sterilization company based in Paso Robles, California. The current vibration table is not programmable and lacks circuit diagrams, making it difficult to repair. In addition, it is not functional due to internal circuitry issues and power requirements. To address these issues, the team will implement several upgrades to improve the product and allow for better random cyclic vibration testing. A full assessment of the existing vibration table will be conducted to ensure the viability of these …

Physical And Digital Models For Timber Design And Analysis Courses, Paulina Robles, Gabrielle Rose Favro, Anahid Behrouzi, Abby Lentz

Architectural Engineering

Among structural engineering education research, there is a limited number of studies on interactive learning tools and activities specifically for the timber design classroom to assist students in visualizing material behavior, vertical and lateral load paths, and construction sequence. Timber design courses within the undergraduate program in the Architectural Engineering department at California Polytechnic State University in San Luis Obispo (Cal Poly), place an emphasis on seismic and wind design. Therefore, the proposed learning tools and activities are intended to pair with an introduction to concepts in the American Wood Council’s National Design Specifications (NDS) and Special Design Provisions for …

Executive Committee - Minutes, 5/30/2023, Academic Senate

Academic Senate Minutes

No abstract provided.

Executive Committee - Agenda 5/30/2023, Academic Senate

Academic Senate Agendas

No abstract provided.

As-958-23 Resolution On The Commendation For Thomas Gutierrez, General Assembly Of The Academic Senate

Academic Senate Resolutions

General Assembly of the Academic Senate presents a commendation for Thomas Gutierrez.

As-959-23 Resolution On Undergraduate Curriculum For Semester Conversion, Academic Senate Curriculum Committee

Academic Senate Resolutions

Resolved to rescind AS 234-87 and AS 609-04 and any other previous policy requiring free electives, but further resolves that the general guidelines for undergraduate curriculum at Cal Poly in the attached policy shall still be adopted. The attached document highlights the general policies on undergraduate curriculum.

Academic Senate - Agenda, 5/23/2023, Academic Senate

Academic Senate Agendas

No abstract provided.

As-960-23 Resolution On Courses With Condensed Time Schedules For Quarter-To-Semester Conversion, Academic Senate Curriculum Committee

Academic Senate Resolutions

Resolves that any semester-system course or group of courses that in its new condensed format averages less than 4 days (including weekends) per unit must be approved by the appropriate College Curriculum Committee(s) and the Academic Senate Curriculum Committee at least 60 days before they are offered in a compressed time scale.

Academic Senate - Minutes, 5/23/2023, Academic Senate

Academic Senate Minutes

No abstract provided.

Teaching Intersectionality: Moving Between Theory And Practice, Janine Armstrong

Feminist Pedagogy

In this critical commentary, I reflect on teaching intersectionality in the classroom. By continuously shifting between theory and practice, students are able to understand and later apply intersectionality. First, I discuss how I introduce intersectionality through classroom discussion. Second, I highlight how the importance of self-reflection and analysis to aid in understanding. Lastly, I mention ways I incorporate intersectionality throughout the course.

Charting Their Own Course: Individualized Contract Grading As A Practice Of Freedom, Sarah Stone Watt

Feminist Pedagogy

Students move through college along different curricular and personal pathways. Feminist scholars have explored multiple ways of inviting students to bring their diverse experiences into the classroom. However, it can be challenging to invite diversity while requiring each student to navigate a standardized curriculum. I propose unilateral grading contracts as one tool to enable students to move through a course while leveraging their strengths, helping them grow, and sharing their experiences to enrich the broader class community and achieve the course learning outcomes.

Digital Waves: Communicating Feminist Movements, Shauna M. Macdonald

Feminist Pedagogy

Online learning provides opportunities for pedagogical growth and innovation. When tasked with teaching an undergraduate Gender and Communication class during a virtual semester (amid the COVID-19 pandemic), I sought ways to engage students through online technologies rather than working against or despite them. The Digital Waves (DW) assignment, one that asks students to research and then create digital representations of a particular “wave” of feminism, was one of several strategies I adopted; it quickly evolved into a favorite.