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Optimization Of Flagellar Locomotion In The Low Reynolds Number Regime, Aidan M. Trodden, Aidan M. Trodden

Physics

This report investigates the computational and theoretical techniques - modeled by E. Lauga and C. Eloy - used to optimize the shape of an activated flagellum for enhanced cell motility. Cell motility is ubiquitous and has a large affect on biological systems such as marine life ecosystems, reproduction, and infection. The physical principles governing flagellar propulsion are explored using computational fluid dynamics simulations, mathematical modeling, and the sequential quadratic programming (SQP) optimization algorithm. Through iterative refinement, we can identify optimized flagellar shapes that would minimize the energetic cost dependent on a single dimensionless sperm numbers (Sp). The computation of the …

Reducing Scope 3 Emissions By Investing In Regenerative Agriculture In Supply Chains, Stephanie Cain

Master's Theses

The agricultural industry has an opportunity to shift to a more sustainable practice that helps restore vital topsoil, improve water quality, reduce environmental impact, and sequester atmospheric carbon into the vast soil carbon pool. However, to implement these practices at considerable scale, agricultural producers require access to resources and capital they rarely have and can be difficult to acquire. As a company, investing in regenerative agriculture in supply chains can lead to reduced Scope 3 emissions, more resilient supply chains, and better marketability as an investment fund, an employer, and a brand. Insetting regenerative agriculture can protect supply chains against …

Food For Thought: The Effects Of Feeding On Neurogenesis In The Ball Python, Python Regius, Hannah F. Bow

Master's Theses

Pythons are a well-studied model of postprandial physiological plasticity. Consuming a meal has been shown by past work to evoke a suite of physiological changes in pythons and elicit one of the largest documented increases in post-feeding metabolic rates relative to resting values. However, little is known about how this plasticity manifests in the brains of ball pythons, Python regius. Previous work using the cell-birth marker 5-bromo-12’-deoxyuridine (BrdU) has shown that cell proliferation in the python brain increases six days following meal consumption. This study aimed to confirm these findings and build on them in the long term by …

Predicting Location And Training Effectiveness (Plate), Erik Rolf Bruenner

Master's Theses

Abstract Predicting Location and Training Effectiveness (PLATE)
Erik Bruenner

Physical activity and exercise have been shown to have an enormous impact on many areas of human health and can reduce the risk of many chronic diseases. In order to better understand how exercise may affect the body, current kinesiology studies are designed to track human movements over large intervals of time. Procedures used in these studies provide a way for researchers to quantify an individual’s activity level over time, along with tracking various types of activities that individuals may engage in. Movement data of research subjects is often collected through …

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Neural Tabula Rasa: Foundations For Realistic Memories And Learning, Patrick R. Perrine

Master's Theses

Understanding how neural systems perform memorization and inductive learning tasks are of key interest in the field of computational neuroscience. Similarly, inductive learning tasks are the focus within the field of machine learning, which has seen rapid growth and innovation utilizing feedforward neural networks. However, there have also been concerns regarding the precipitous nature of such efforts, specifically in the area of deep learning. As a result, we revisit the foundation of the artificial neural network to better incorporate current knowledge of the brain from computational neuroscience. More specifically, a random graph was chosen to model a neural system. This …

Analyzing Tortuosity In Patterns Formed By Colonies Of Embryonic Stem Cells Using Topological Data Analysis, Jackie Driscoll

Master's Theses

Pluripotent stem cells have been observed to segregate into Turing-like patterns during the early stages of Dox-inducible hiPSC differentiation. In this thesis, we de- velop a tool to quantify the tortuosity in the patterns formed by colonies of pluripo- tent stem cells using methods from topological data analysis. We use clustering techniques and the mapper algorithm to create simplicial complexes representing samples of cells and detail a method of evaluating the tortuosity of these complexes. We use the resulting persistence landscapes and their associated norms to evaluate experimental data and simulated data from an agent based model. This thesis finds …

Effects Of Mature Recombinant Gdf9 And Bmp15 On In-Vitro Maturation Of Bovine Oocytes And Subsequent Embryo Development And Effects Of Antioxidants On Blastocyst Re-Expansion Rates, Jamie Thompson

Master's Theses

In-vitro produced embryos (IVP) differ greatly from in-vivo derived embryos (IVD) in gene expression, metabolism, development, and cryotolerance which limit the widespread use of this technology. In-vitro maturation (IVM) is one of the most important components for successful in-vitro embryo development. Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) have been found to be essential during oocyte maturation and thus female fertility. These proteins are oocyte secreted factors (OSFs) and are produced with pro- and mature protein regions where the pro-regions are thought to aid in protein folding and dimerization where heterodimerization the two proteins has been …

California's Native Trees And Their Use In The Urban Environment, Camille Pawlak, Natalie Love, Jennifer Yost, Andrew Fricker, Jacqueline Doremus, Matthew Ritter

Master's Theses

California’s urban forest is composed of both native and non-native species. These trees improve the quality of life of urban residents and mitigate the effects of climate change by buffering local microclimates. A species’ native status is often defined at the scale of the state’s political boundaries, which doesn’t reflect its actual native range. Here we define the list of 95 tree species native to California, create digital range maps for each species, provide native species lists for every city in California, and analyze trends in native tree species in the state’s urban areas. We found that California’s urban areas …

Reservoir System For Tissue-On-A-Chip, Olivia Corvelli, Kyle Cekada, Ryan Adams

Biomedical Engineering

Dr. Christopher Heylman’s research laboratory needs an improved reservoir system for their microfluidic device that reduces flow variance, failures, and the physical footprint. Current microfluidic devices have various types of reservoir systems, including vials, 96-well plates, and other cylindrical wells. Several patents and standards must be considered when designing the reservoir system. To develop a prototype the following design process was used: product discovery, project planning, product definition, conceptual design, product development. Dr. Heylman expressed various customer requirements including increased time between cell media changes, reduced leaks and blockages, and reduced flow variance. These were then translated into engineering requirements. …

Diffusion-Driven Aggregation Of Particles In Quasi-2d Membranes, Oscar Gullickson Rausis

Physics

Many biological membranes can be modeled as two-dimensional (2D) viscous fluid sheets surrounded by three-dimensional (3D) fluids of different viscosity. Such membranes are dubbed quasi-2D as they exhibit properties of both 2D and 3D fluids. The Saffman length is a parameter that describes the energy exchange between the membrane and bulk fluids and controls the cross-over from 2D to 3D hydrodynamics. We aim to model diffusion-driven aggregation of particles embedded in a quasi-2D membrane. It is known that hydrodynamic interactions between solute particles significantly reduce their aggregation rate in 3D fluids. It is expected that in quasi-2D membranes the reduction …

Detecting Alzheimer's Disease Using Artificial Neural Networks, Sally Lee, Mia Keegan

Electrical Engineering

This project aims to use artificial neural networks (ANN) in order to detect Alzheimer’s disease. More specifically, convolutional neural networks (CNN) will be utilized as this is the most common ANN and has been used in many different image processing applications. The purpose of using artificial neural networks as a detect method is so that an intelligent way for image and signal analysis can be used. A software that implements CNN will be developed so that users in medical settings can utilize this software to detect Alzheimer’s in patients. The input for this software will be the patient’s MRI scans. …

An Interactive Ecosystem Simulator, Tong Zhou

Computer Science and Software Engineering

This project is about an ecosystem simulator game that allows players to manipulate the population size of the selected species and observe these species interact with each other. It focuses on reflecting the consequences of human intervention in the ecosystem and the difficulty of maintaining a balanced ecosystem. I’ve been astonished by how human intervention could easily crash the ecosystem and how difficult it could be to make up for our faults. And many people still hold the thought that we control the world and could determine the death or live of all other creatures as we like. However, the …

Wave Energy Converter For Marine Vessels And Isolated Communities, Leo Kirshenbaum, Owen Pyle, Gage Howard, Charlie Camilli, Jonathan Ma, Emigdio Islas, Joseph Bonafede

Mechanical Engineering

California Polytechnic State University’s 2023 Marine Energy Collegiate Competition team, Surf Supply, has developed a floating dock that transduces wave energy into electricity. The following report aligns with MECC requirements, and our design changes since CDR are present in the User Manual in Appendix F. Our primary market research of the Blue Economy identified electric marine vessel charging and isolated communities as early adopters that could benefit most from the first generation of our wave energy converter (WEC). Surf Supply’s design concept provides a reliable, affordable, and renewable energy source that reduces dependency on conventional fossil fuels, allowing blue economy …

Therapeutic Mechanical Horse Project, Broghan Martin, Carson Roff, Zach Barnisham, Lydia Barnes

Mechanical Engineering

This project team created a simple mechanical model of a horse that disabled children could ride on to feel more comfortable partaking in equine therapy. This project was sponsored by Jack’s Helping Hand as part of their equine therapy program. The team went through the entire design process of researching, ideating, prototyping, and testing to create the final product. Finite element analysis of the structural members of the horse was performed. The forces used in that model were later validated through testing of the strength of those same members after manufacturing. In the end, a self-actuating single degree of freedom …

The Effect Of Adding Mango To A Breakfast Meal On Glycemic And Satiety Responses And Next Meal Energy Consumption, Natalie R. Ramos

Master's Theses

Spikes in blood glucose (BG) result in adverse health consequences in people with and without diabetes. This study aimed to compare the BG and satiety responses of adding mango or sugar to a high glycemic load (HGL) breakfast. A randomized, controlled trial (cross-over design) was conducted with 18 participants. Participants consumed cornflakes and almond milk (Control), control plus 34gm added sugar (ASug), or added mango (AMango) with 34gm carbohydrate. BG was determined at fasting, 15, 30, 60, 90, 120min postprandial; satiety was rated with a visual analog scale at each time point. At 120min, subjects consumed a snack of hummus …

Investigation Of Placement Of Polyethylenimine Within Thin Film Composite Reverse Osmosis Membranes For Enhanced Anti-Fouling Properties, Taylor F. Austin

Master's Theses

Fresh water scarcity is an alarming issue for communities across the globe. The development of water recycling and reuse technologies has become crucial in expanding the limited water resources. Reverse osmosis (RO) is among the key processes that can treat wastewater to meet potable water reuse standards. Despite the advancements in RO membrane technologies, many challenges persist regarding the operation and maintenance of RO membranes, such as membrane fouling. Extensive research investigations have focused on developing RO membrane modifications to combat the decreased performance due to fouling. Polyethylenimine (PEI) is a promising polymer used for enhancing the anti-fouling properties of …

The Development Of Sexual Health Educational Canvas Modules For Cal Poly Students, Alexa J. Asson, Dillan Chiewpanich, Amanda Hodges, Tanya Patil

Biological Sciences

Purpose: Sexual health education continues to be a taboo topic underrepresented in young adult health education. Many high school students do not receive the sexual health education they need. One study found that 34% of girls and 42% of boys left high school without education on birth control methods (Wong et al., 2019). Furthermore, students entering college have varying, often inadequate, levels of sexual health knowledge. After examining sexual health data at California Polytechnic State University (Cal Poly), the Cal Poly Sexual and Reproductive Health (SRH) Lab found that students engage in risky sexual behaviors. For example, nearly one quarter …

The Development Of Sexual Health Educational Canvas Modules For Cal Poly Students, Alexa Jordan Asson, Dillan Isabella Chiewpanich, Amanda Hodges, Tanya Patil

Kinesiology and Public Health

Purpose: Sexual health education continues to be a taboo topic underrepresented in young adult health education. Many high school students do not receive the sexual health education they need. One study found that 34% of girls and 42% of boys left high school without education on birth control methods (Wong et al., 2019). Furthermore, students entering college have varying, often inadequate, levels of sexual health knowledge. After examining sexual health data at California Polytechnic State University (Cal Poly), the Cal Poly Sexual and Reproductive Health (SRH) Lab found that students engage in risky sexual behaviors. For example, nearly one quarter …

Filters For Fiji: A Modified Cracker Box Biosand Filter For Rural Fiji, Geneva Newell, Cameron Lowrey, Thomas Burt, Lexie Caterine

Civil and Environmental Engineering

Water quality remains a major issue throughout rural Fiji, as current solutions rely on outside organizations providing money or technology. The goal of Filters for Fiji’s research was to develop a sustainable water filtration method for the people of rural Fiji, through ethnographic and biological research. In order to be sustainable, the filter had to be inexpensive (less than USD$15), simply built and maintained, and suitable for the end-user. The driving question of the research was: can a plastic, modified biosand filter be constructed from materials that could be sourced locally in rural Fijian communities? To answer this question, feedback …

The Effects Of Dissolved Hydrogen On The Mechanical Properties And Fracture Behavior Of Se508 Nitinol Wire For Biomedical Components, Kathryn Linn Meany, Ryan Zhao Thompson

Materials Engineering

Superelastic nitinol is competitive in the medical device industry due to its unique properties. Typical processing methods, such as electropolishing and etching, can introduce hydrogen into nitinol’s microstructure, which is known to affect its tensile properties. Due to the lack of information about hydrogen content in processed nitinol, an experiment was designed to find a relationship between hydrogen content and SE508 nitinol wire’s tensile strength, permanent set, ductility, and mode-of-failure of the fracture surface. Using a 50% sulfuric acid to mimic industry practices, five wire samples were exposed to the acid solution at seven different time intervals (ranging from 0 …

Efficacy Of Pure Bioscience Surface Disinfectant On Varying Bacterial Strains, Isabelle R. Mckenzie

Biological Sciences

Agriculture represents a crucial aspect of the acquisition of food resources in modern society. Consequently, it is a paramount undertaking to process crops devoid of any pathogenic agents. A cleaning product named Pure Hard Surface Disinfectant was presented by Pure Biosciences, acclaiming its capacity to destroy bacteria and fungi, while impeding their proliferation for an extended duration following application. This pilot project sought to quantify the efficacy of Hard Surface Disinfectant. Empirical observations conducted thus far have concentrated on surveying the immediate effects of the principal ingredient, silver ion, on diverse bacterial strains. Future prospects for this project include a …

Integrative Analyses Of Genomic And Metabolomic Data Reveal Molecular Mechanisms Associated With Uterine Disease Traits In Transitioning Dairy Cattle, Leanna C. Sanchez, Mohammed Abo-Ismail, Daniel Peterson, Fernando Campos-Chillon

Master's Theses

The metritis complex (MC), characterizing post-partum uterine diseases in dairy cattle has negative implications on animal welfare, production efficiency, and the economic stability of the dairy industry. The studies in this thesis aimed to investigate the genetic architecture of the metritis complex and identify genomic regions and metabolites associated with the development of MC. Thereby enhancing our understanding of the biological pathways and molecular mechanisms involved in the pathophysiology of MC during the transition period in Jersey and Holstein dairy cattle.

Chapter 2 sheds light on the previous work done on MC. The goals of this review were to (1) …

Southern Sea Otter (Enhydra Lutris Nereis) Fur Morphology, Thermal Function, And Buoyancy Across Ontogeny, Kate Riordan

Master's Theses

Sea otters (Enhydra lutris) have the densest fur of any animal, and the hairs function to trap a layer of air that is used for insulation. When a sea otter is born, it has a natal pelage (baby fur), and sea otters eventually molt that fur and replace it with a pelt resembling the adult fur. Sea otter fur is composed of 3 types of hairs: underhairs, intermediate hairs, and guard hairs. Sea otters are more susceptible to the negative effects of oiling from oil spills compared to other marine mammal species because they solely rely on fur …

Photophoretic Optical Trapping, Essa Ababseh

Electrical Engineering

Photophoretic Optical Trapping (POT) is a relatively new concept in the field of optics which has potential application in 3D display. The POT is realized by confining a particle within a very small location of the optical system, mostly around the focus. The particle, if captured by the beam, has the potential to print visible 3D images in free space. Our POT system is encapsulated by an acrylic enclosure, which also incorporates a biconvex lens as well as an adjustable focus laser module. Particles are released around the top of the lens’ focal point until the captured particle can be …

Spice Modeling Of Biosensing Field-Effect Transistor, Alex Castro

Electrical Engineering

This project created a user manual on how to generate an easily configurable and implementable Spice model for Field Effect Transistor (FET) devices created in the Cal Poly clean room. The document contained step by step procedures depicting the proper execution techniques and example results for different experiments required to gather the proper information for these models. This testing methodology was shown for finding the numerous different device parameters of a FET, including the I-V curves, threshold voltage, and subthreshold current values. The manual then described how to transfer this data into a new Spice model to allow for simulation …

Child Sexual Assault Prevention And Intervention, Kira Peterson, Amaya Ibuna, Emily Valenzuela

Psychology and Child Development

In our paper, we discuss child sexual assault, its risk factors, short and long-term outcomes, as well as prevention and intervention programs that have been shown to be valuable. To limit research, our focus will be on children living in the United States who have been physically sexually assaulted. To spread awareness of child sexual abuse, we also developed a pamphlet (See Appendix) that will be distributed to CASAs, which stands for Court Appointed Special Advocates. The development of the pamphlet is described in the combined Method and Results section. We conclude our project and paper with a Discussion section …

Surface Characterization Of Low-Density Polyethylene Mulch, Risha Shah

Materials Engineering

Plastic pollution in aquatic systems has traditionally been highlighted in past and current research due to the increase in plastic production every year. Unfortunately, quantitative and qualitative data regarding plastic pollution on land systems such as agricultural mulch is limited. Agricultural mulch breaks down into macroplastics and then degrades into microplastics. The microplastics investigated in this study are all secondary microplastics: microplastics that form due to weathering of larger fragments of plastic. Weathering can occur due to a variety of factors; however, UV radiation and mechanical weathering have been the factors of focus on most current research in microplastic formulation. …

Bruxism Biofeedback Device, Claire A. Dossey, Errin S. Abasolo, Isabelle A. Starr

General Engineering

This paper aims to summarize the design process for a biofeedback bruxism device, covering the necessary background research, engineering requirements, design process, prototyping, manufacturing, and testing for the device. The purpose of this project was to design an engineering solution for the treatment of bruxism. This entails both measuring and significantly reducing clenching and grinding during sleep, as many current solutions may reduce symptoms of the disorder, but do not treat bruxism itself. Engineering requirements included biocompatibility, size and weight, electrical safety, and easy of use and comfort. Many design options were proposed, and a Pugh Matrix was used to …

Marine Protected Areas And Oceanographic Variability: Impacts On Blue Rockfish (Sebastes Mystinus) And The Human Dimensions Of Collaborative Fisheries Research, Erin M. Johnston

Master's Theses

Fishing pressure and environmental variability are two of the most impactful drivers of fish populations worldwide. It is critical to effective management to understand the intersection between the two and how each may affect fish population dynamics, especially for exploited nearshore species like rockfishes (Sebastes spp.). This is especially true as models indicate that global climate change will dramatically increase the frequency and severity of large-scale oceanographic perturbations. We were interested in whether we could detect changes in relative abundance of nearshore rockfishes relative to large-scale oceanographic events using a broad-scale index like the Multivariate Ocean Climate Indicator …

Composite Solid Rocket Motor Case Optimization With Matlab Genetic Algorithm, Aleksandr Breit

Master's Theses

This study utilizes MATLAB genetic algorithm (GA) to perform optimization on a solid rocket motor (SRM) chamber structure. The (SRM) structure is modelled as a cylindrical composite laminate where unidirectional fiber orientations are the primary design variable in the optimization problem formulation. Additional design variables such as chamber length, diameter, and internal pressure are altered along with the ply angles to minimize the safety margin towards a near-zero value and encourage efficient layup design. Classical lamination theory with Tsai-Wu failure criterion are used to calculate ply-level safety margins. A thickness minimization scheme is employed to reduce the ply count from …