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Investigation Of Chromosome Size Effect On The Rate Of Crossovers In The Meiotic Yeast Saccharomyces Cerevisiae, Lanie Maria Galland

Master's Theses

Meiosis is a specialized type of cell division characterized by a single round of DNA replication and two rounds of chromosome segregation, ultimately resulting in four haploid cells. During meiosis I, chromosomes align and reciprocal recombination results in the formation of a crossover, creating the tension required to properly segregate homologs during the first round of meiosis.

Two mechanisms involved in regulating the occurrence of crossing over are assurance and interference. Crossover assurance describes the phenomenon that at least one crossover will form between each pair of homologous chromosomes during prophase I. Crossover interference, on the other hand, describes the …

Development And Implementation Of Assessment Methods For Tissue-Engineered Blood Vessel Mimics, Tanner Stevenson

Biomedical Engineering

Coronary Artery Disease (CAD), the most prevalent form of heart disease, is the result of clogged or damaged coronary arteries and claims around 380,000 Americans annually. A common treatment for CAD involves placing a stent into the artery in order to open the lumen and support the native tissue—a procedure that drastically reduces patient recovery times in comparison to heart bypass surgery. However, stents do not always interact well with the body and require additions such as surface coatings or drug elution in order for additional biocompatibility. These additions necessitate extensive in vitro and in vivo testing which are expensive …

Endothelial And Smooth Muscle-Dependent Vascular Reactivity In Immature Arterialized Collateral Capillaries, Caitlin Koeroghlian

Biomedical Engineering

Peripheral arterial occlusive disease (PAOD) occurs due to the build up of atherosclerotic plaque and reduces blood flow to cause chronic ischemia. Patients with PAOD may experience intermittent claudication, or the pain in limb skeletal muscles due to a decease in blood flow. Collateral arteries can act as a natural bypass and improve blood flow to hypoxic tissue by creating an alternate route for blood to flow, but not all patients with PAOD have pre-existing collateral networks. Animal studies indicate that tissues without pre-existing collateral networks can form de novo collaterals from capillaries following occlusion of a feed artery. Unfortunately, …

From Print Culture To Digital Culture: Effects On Communication, Culture, And Technology, Brent Weber

Communication Studies

No abstract provided.

Child Life Specialists’ Facilitation Of Family-Centered Care: The Importance Of Sibling Support, Carissa L. Lane

Psychology and Child Development

Certified Child Life Specialists’ understanding of family-centered care, and their beliefs and practices involving siblings of chronically/critically ill children were examined using an online survey. Participants were Certified Child Life Specialists recruited form the Child Life Council Forum. Relationships between utilization of certain words and support programs offered to siblings, were examined. Findings revealed a relationship in one area of coded language and support program for siblings, but not the other. Findings also revealed that all CCLS believe in the inclusion of siblings during the treatment process, however they are offered less support services than parents. Diverse results regarding multiple …

Water In The 21st Century, Grayson Michael Shor

Social Sciences

The aim of this research project is to provide a comprehensive and global analysis of water use in order to provide the reader with a comprehensive grasp of current and impending issues. The included five (5) chapters discuss water distribution, conservation, purification, law, international development, economic debates, ethical consideration, as well as educated estimations of the effects water related issues may cause in the next one-hundred years.

Cooperative Construction In Schools In California, John Mauck Donley

Master's Theses

Cooperative Construction in Schools in California

John M. Donley

The construction industry has lost efficiency since 1964, while becoming increasingly more litigious. Schools in California can ill afford the time to allow the construction industry time to fully evolve. It may take years or decades to fully improve the efficiency of, and reduce the conflict within the construction industry.

At the same time, the construction industry has developed new processes to improve efficiency and reduce conflict. These processes are beginning to be broadly embraced by the industry. They all contain cooperative elements. Taken together they represent a new organizing principle …

Dielectric Spectroscopy Of De Vries Smectic Liquid Crystals, Clayton Wesley Thatch

Physics

In this experiment we used dielectric spectroscopy to observe the dielectric response of two De Vries liquid crystals; W-652 and W-751. A frequency sweep was run for each sample with various electric fields applied using an AC current. The samples demonstrated opposing effects at the SmA to SmC as the electric fields were increased. The W-751 showed an increased response with an increased electric field and a resonance peak in high frequencies that shifted through the transition, although there were no clear results in the low frequency range so there is no conclusive trend. The W- 652 sample opposed the …

Cosleeping: A Universal Human Phenomenon, Sarah E. Nasatir-Hilty

Social Sciences

No abstract provided.

A Biomedical And Biocultural Approach To The Hispanic Paradox, Tess Wianecki

Social Sciences

No abstract provided.

Nutrition Transition In California: Examination Of The Nutrition Profile, Desiree Rodriguez

Social Sciences

No abstract provided.

Design Analysis Of An Air Force Fuel Cell Maintenance Hangar, Andrew Carmean

Fire Protection Engineering: Culminating Experience Project Reports

A Fuel Cell Maintenance Hangar (FCMH) was constructed in 2013 based on a 2012 design; Figure 1.1.1 is a rendering shown below. This report evaluates the design for life safety, and property protection systems. The facility was designed based on Air Force standard prescriptive methods; the resultant design is compared to minimum prescriptive methods and to as-built drawings. In addition, the property protection design criteria were evaluated by simulating the maximum expected design fire in a hangar bay 1 using Fire Dynamics Simulator (FDS). Section 1 consists of a general overview of the FCMH including descriptions of the facility and …

Fully Accessible Raised Garden Beds, Ethan Lockwood

Liberal Arts and Engineering Studies

The Ranch, a local nonprofit that is a community gathering location for recreation and education, providing outdoor employment opportunities for area residents with developmental disabilities and a unique experience for volunteers and visitors., was lacking a farming and gardening environment that was fully accessible for all people including those in wheelchairs. This project provided substantial background research for the mission of The Ranch, demonstrated sustainable design, secured material donations, CAD modeled raised beds, and provided meaningful employment during the construction of the raised beds. The project resulted in three different raised bed designs that are all in use by The …

Photosynthetic Thermal Tolerance And Recovery To Short Duration Temperature Stress In Desert And Montane Plants: A Comparative Study, David William Gallagher

Master's Theses

• Climate change models predict an increase in frequency and amplitude of extreme weather events, including heat waves. To better predict how the composition and distribution of plant assemblages might respond to these changes in temperature, it is important to understand how species currently respond to these extremes. Photosynthetic thermal tolerance (T₂₅)and photosynthetic recovery (RT₂₅) were quantified in 27 species. We also studied the relationships between T₂₅, RT₂₅ and leaf mass per area (LMA). Leaf temperature was also monitored in the field.
• Leaves used in this study were collected from two distinct …

Dual High-Voltage Power Supply For Use On Board A Cubesat, Nicholas Weiser

Master's Theses

Since their conception in 1999, CubeSats have come and gone a long way. The first few that went into space were more of a “proof of concept,” and were more focused on sending simple data and photographs back to Earth. Since then, vast improvements have been made by over 40 universities and private firms, and now CubeSats are beginning to look towards interplanetary travel. These small satellites could provide a cost effective means of exploring the galaxy, using off the shelf components and piggy-backing on other launch vehicles with more expensive payloads. However, CubeSats are traditionally launched into Low Earth …

Consumer Evaluation Of Cheese: Linking Hedonics, Emotions And Perception Of Product Attributes, Kristine Patricia Martinez

Master's Theses

As the food industry continues to grow and the marketplace becomes saturated with similar products, consumer researchers and sensory scientists are looking to dig deeper into the minds of consumers to reveal greater distinctions between products and ultimately deliver multi-dimensionally desirable products to consumers. Concurrently, rates of adult and childhood obesity have been increasing nationwide. Food companies are now facing a paradigm shift as health initiatives and consumers are beginning to demand healthier alternatives to commonly consumed food products. With this in mind, it has become imperative to identify product attributes that drive consumption so they can be replicated in …

Neuromodulation: Action Potential Modeling, Vladimir Ruzov

Master's Theses

There have been many different studies performed in order to examine various properties of neurons. One of the most important properties of neurons is an ability to originate and propagate action potential. The action potential is a source of communication between different neural structures located in different anatomical regions. Many different studies use modeling to describe the action potential and its properties. These models mathematically describe physical properties of neurons and analyze and explain biological and electrochemical processes such as action potential initiation and propagation. Therefore, one of the most important functions of neurons is an ability to provide communication …

Design And Validation Of A Wearable, Continuous, And Non-Invasive Hydration Monitor That Uses Ultrasonic Pulses To Detect Changes In Tissue Hydration Status, Zoie Engman

Master's Theses

Chronic dehydration is an endemic problem for many population groups. Current methods of monitoring hydration status are invasive, time consuming, cannot be performed while exercising, and require lab resources. A proposed solution is a wearable, continuous, and non-invasive device that uses harm-free ultrasonic pulses to detect changes in tissue hydration status over time. Customer and engineering requirements were defined and used to guide the design process. Literature reviews were performed to identify essential information on dehydration, assess current methods, discover state of the art devices, and describe ultrasonic theory. Market research was performed to identify athletes as the target population …

Thermal Numerical Analysis Of Vertical Heat Extraction Systems In Landfills, Michael Thomas Onnen

Master's Theses

An investigation was conducted to determine the response of landfills to the operation of a vertical ground source heat pump (i.e., heat extraction system, HES). Elevated landfill temperatures, reported various researchers, impact the engineering performance of landfill systems. A numerical model was developed to analyze the influence of vertical HES operation on landfills as a function of climate and operational conditions.

A 1-D model of the vertical profile of a landfill was developed to approximate fluid temperatures in the HES. A 2-D model was then analyzed over a 40 year time period using the approximate fluid temperatures to determine the …

A Multi-Gpu Compute Solution For Optimized Genomic Selection Analysis, Trevor Devore

Master's Theses

Many modern-day Bioinformatics algorithms rely heavily on statistical models to analyze their biological data. Some of these statistical models lend themselves nicely to standard high performance computing optimizations such as parallelism, while others do not. One such algorithm is Markov Chain Monte Carlo (MCMC). In this thesis, we present a heterogeneous compute solution for optimizing GenSel, a genetic selection analysis tool. GenSel utilizes a MCMC algorithm to perform Bayesian inference using Gibbs sampling.

Optimizing an MCMC algorithm is a difficult problem because it is inherently sequential, containing a loop carried dependence between each Markov Chain iteration. The optimization presented in …

Laser Speckle Imaging: A Quantitative Tool For Flow Analysis, Taylor A. Hinsdale

Master's Theses

Laser speckle imaging, often referred to as laser speckle contrast analysis (LASCA), has been sought after as a quasi-real-time, full-field, flow visualization method. It has been proven to be a valid and reliable qualitative method, but there has yet to be any definitive consensus on its ability to be used as a quantitative tool. The biggest impediment to the process of quantifying speckle measurements is the introduction of additional non dynamic speckle patterns from the surroundings. The dynamic speckle pattern under investigation is often obscured by noise caused by background static speckle patterns. One proposed solution to this problem is …

Monarch Butterfly (Danaus Plexippus) Tree Preference And Intersite Movement At California Overwintering Sites, Jessica Lynn Griffiths

Master's Theses

Managing Monarch butterfly overwintering groves: making room among the eucalyptus

Proper management and conservation of the coastal California overwintering sites used by western Monarch butterflies (Danaus plexippus L.) is critical for continued use of these sites by monarchs. Many management efforts are currently concentrating on eucalyptus-only sites because of the prevailing notion that monarchs prefer eucalyptus over native tree species. Yet, whether a preference exists or not has never been tested. Herein, we test the “eucalyptus preference” hypothesis with data from five overwintering sites comprised of blue gum eucalyptus (Eucalyptus globulus) and at least one other native tree …

Development Of Novel Anti-Microbial Plant Essential-Oil Treatments To Reduce The Postharvest Incidence Of Botrytis Cinerea Of Strawberries, Ryan C. Brantley

Master's Theses

Fresh strawberries have grown into a multi-billion dollar industry over the last few decades in California. Botrytis cinerea or grey mold, is the worst pathological disorder affecting strawberry fruit causing cull rates of up to 30% in the worst seasons. Strawberry fruits are fragile and have a short shelf-life making timely harvest, cooling, and marketing an absolute necessity. The current industry standard is to ship strawberries in an overwrapped CO₂-enriched headspace pallet in refrigerated trucks at 33 °F. However, B. cinerea has the ability to grow at very low temperatures and continues to plague the strawberry industry during postharvest storage …

A Proof Of Concept For Crowdsourcing Color Perception Experiments, Ryan Nathaniel Mcleod

Master's Theses

Accurately quantifying the human perception of color is an unsolved prob- lem. There are dozens of numerical systems for quantifying colors and how we as humans perceive them, but as a whole, they are far from perfect. The ability to accurately measure color for reproduction and verification is critical to indus- tries that work with textiles, paints, food and beverages, displays, and media compression algorithms. Because the science of color deals with the body, mind, and the subjective study of perception, building models of color requires largely empirical data over pure analytical science. Much of this data is extremely dated, …

Integrated Senior Housing, Kyungok Ha

Master's Theses

It is difficult to have an integrated population throughout all age strata in a society. Especially if one considers the growing percentage of the aged population and their feeling alienated in their current physical surroundings. In order to solve imminent problems with the growing elderly population, a primary task should be considering how to improve the housing of senior citizens. Furthermore, bringing the youth and elderly together would produce a functioning self-help system. It engenders interaction strategies by employing the strengths of one generation to serve another generation’s needs. This idea was introduced by the systemic family therapist Gerhard Schiele. …

Oceano Community Health Plan, Eugene Phillip Brennan

Master's Theses

ABSTRACT

Oceano Community Health Plan

Phillip Brennan

Recent, mounting research shows that chronic disease, the leading causes of death and primary driver of health care costs, cannot be effectively addressed through education or preventative health alone. A physical environment that promotes health—through access to healthy food, opportunities for physical activity, quality housing, transportation options, and safe schools—is an integral part of making our communities healthier. This research and accompanying Healthy Community Plans will serve as a way for the County to begin looking in-depth at the ways the built environment (our streets, parks, and neighborhoods) contribute or detract from the …

The Role Of Sirtuin Inhibitors On The Proteomic Responses Of The Mussels Mytilus Galloprovincialis And Mytilus Trossulus To Menadione Induced Oxidative Stress, Hayley C. Chilton

Master's Theses

Global climate change imposes physiological constraints on marine ecosystems that can alter the distribution of intertidal organisms. In one such instance, the native cold-adapted mussel Mytilus trossulus is being replaced along its southern range by the invasive warm-adapted Mytilus galloprovincialis. These blue mussels occur throughout rocky intertidal zones where they are subjected to greatly varying environmental conditions known to induce oxidative stress. We hypothesize that while under acute stress, related Mytilus congeners undergo a shift in redox potential from NADH-fueled respiratory pathways to pathways producing NADPH as a way to decrease the production of reactive oxygen species (ROS) and …

Nonlinear Internal Waves, Internal Bores, And Turbulent Mixing In The Nearshore Coastal Environment, Ryan K. Walter

Physics

The nearshore coastal environment is generally taken to be one of the most productive and ecologically important parts of the ocean. The nearshore is also a complex environment from a physical standpoint, due in large part to the widespread and often irregular occurrence of nonlinear internal waves (NLIWs) that frequently appear more bore-like than wave-like. Indeed, this region of the ocean can be thought of as the “swash zone” for larger-scale internal wave fields on the continental shelf. These nearshore NLIWs and bores have considerable implications for the cross-shelf exchange and transport of nutrients, sediments, contaminants, larvae, and other scalars; …

The Effect Of Neurostimulation On Blood Flow And Ischemic Pain, Stacey M. Fishman

Biomedical Engineering

Chronic pain caused by lack of blood flow is known as ischemic pain. Neurostimulation, the application of electrical currents through a region of the body, is effective for pain modulation, and it is hypothesized that this can be explained by the gate control theory and alterations of the sympathetic output initiated by the metaboreflex. The decrease of sympathetic output reduces vasoconstriction and improves blood flow. Transcutaneous electrical nerve stimulation (TENS) and interferential currents (IFC) stimulation, both non-invasive neurostimulation techniques, were evaluated for their effects on cutaneous blood flow on the palm. High or low frequency TENS and/or IFC, and the …

May 29, 2014 Cal Poly Report, Public Affairs Office

Cal Poly Report

No abstract provided.