Digital Commons Network^™

Deciphering The Contribution Of Microglia To Neurodegeneration In Friedreich's Ataxia, Sydney N. Gillette

Master's Theses

Friedreich's ataxia (FRDA) is the most prevalent inherited ataxia, affecting one in every 50,000 individuals in the United States. This hereditary condition is caused by an abnormal GAA trinucleotide repeat expansion within the first intron of the frataxin gene resulting in decreased levels of the frataxin protein (FXN). Insufficient cellular frataxin levels results in iron accumulation, increased reactive oxygen species production and mitochondrial dysfunction. Tissues most heavily impacted are those most dependent on oxidative phosphorylation as an energy source and include the nervous system and muscle tissue. This is evident in the clinical phenotype which includes muscle weakness, ataxia, neurodegeneration …

Morp: Monocular Orientation Regression Pipeline, Jacob Gunderson

Master's Theses

Orientation estimation of objects plays a pivotal role in robotics, self-driving cars, and augmented reality. Beyond mere position, accurately determining the orientation of objects is essential for constructing precise models of the physical world. While 2D object detection has made significant strides, the field of orientation estimation still faces several challenges. Our research addresses these hurdles by proposing an efficient pipeline which facilitates rapid creation of labeled training data and enables direct regression of object orientation from a single image. We start by creating a digital twin of a physical object using an iPhone, followed by generating synthetic images using …

An Analysis Of Indoor Air Quality At Cal Poly For Sensor Design, Isabella M. Santi

Master's Theses

Prior research has shown that indoor air quality (IAQ) impacts cognitive performance. At Cal Poly, many older buildings are unable to maintain appropriate IAQ because of their outdated ventilation systems and the increasing number of students in the rooms. This work analyzes the IAQ of different buildings at Cal Poly, with a focus on Building 20. Carbon dioxide, temperature, and relative humidity inside classrooms are collected using an integrated circuit sensor and a microcontroller. A total of 38 hours of data was collected, with 22 of those hours in Building 20 specifically. We find that unlike temperature and relative humidity, …

Jorge Ricardo Masetti: Journalist, Guerrilla, Cold Warrior, Brooks C. Martin Mr.

Master's Theses

The following thesis describes the life and activities of Jorge Ricardo Masetti, an Argentinian journalist who was assigned to interview Fidel Castro, leader of the Cuban Revolution against dictator Fulgencio Batista. Masetti was responsible for broadcasting interviews with Fidel Castro and Ernesto “Che” Guevara to the rest of Latin America for the first time, allowing people to understand what was happening in Cuba through the words of the Revolution’s leaders. Masetti returned to Cuba to found the first international Latin American news agency, Prensa Latina, which still exists today. However, ideological factionalism within Prensa Latina drove Masetti to resign in …

Using Plankton Edna To Estimate Whale Abundances Off The California Coast: Data Integration And Statistical Modeling, Katherine Chan

Master's Theses

Understanding marine mammal populations and how they are affected by human activity and ocean conditions is vital, especially in tracking population declines and monitoring endangered species. However, tracking marine mammal populations and their distribution is challenging due to difficulties in observation and costs. Using surrounding plankton environmental DNA (eDNA) has the potential to provide an indirect measure of monitoring cetacean abundances based on ecological associations. This project aims to apply statistical methods to assess the relationship of visual abundances of common species of baleen whales with amplicon sequence variants (ASV) of plankton eDNA samples from the NOAA-CalCOFI Ocean Genomics (NCOG) …

Coolsplint: Inflammation Reduction Accessory, Laura C. Denney, Winston H. Giang, Aanchal Singh

Biomedical Engineering

This document outlines a project sponsored by Elizabeth Mentel and Michael Clausson that addresses the shortcomings in current splinting options, particularly for wrist fractures in elderly patients. Stakeholders include clinicians, patients, and emergency medical technicians. Multiple improvements can be made to current splinting options to help alleviate inflammation along with splint versatility, affordability, accessibility, and ease of use. After determining the critical customer requirements, the primary objective of this project was to find a way to manage inflammation. The project explores existing splinting solutions and proposes a new design that utilizes cooling rods to reduce inflammation. The document reviews various …

'Glow Up' & 'Geoglyph Animated', Bobby Groth, Frank Cooke

.RAW Journal of Art and Design

No abstract provided.

Table Of Contents, Sarai Devi Dasi

.RAW Journal of Art and Design

No abstract provided.

Full Issue, Sarai Devi Dasi, Vivian Jameson

.RAW Journal of Art and Design

No abstract provided.

Academic Senate - Agenda, 5/21/2024, Academic Senate

Academic Senate Agendas

No abstract provided.

Manufacturing Silicone In-House For The Creation Of Customized Neurovascular Blood Vessel Mimics, Jacob Wilbert Perisho

Master's Theses

The Tissue Engineering Lab at California Polytechnic State University San Luis Obispo focuses on creating tissue-engineered Blood Vessel Mimics (BVMs) designed for the preclinical testing of neurovascular devices. These BVMs are composed of silicone models, representing anatomically accurate neurovasculatures, that are sodded with vascular cell types and then cultivated in bioreactors (which maintain physiologic conditions). These silicone models are currently sourced externally from industry partners, so the primary goal of this thesis was to develop the means and methods for the Tissue Engineering Lab to manufacture silicone models in-house.

The first aim of this thesis was to develop and explore …

Aged 539 Graduate Internship Report - Clovis East High School, Kaylee C. Santos

Agricultural Education: Graduate Internship Reports

This internship/project report includes documentation required in meeting the quality criteria for secondary-level programs of instruction in agriculture. The documents are concurrently used for the Agriculture Incentive Grant review process at Clovis East High School conducted by representatives of the California Department of Education. The supporting material includes information to receive state and local funding, outline the goals and objectives of the program, along with an overview of Clovis East High School, the agriculture program and the community. The project includes the revision of the Agrisciene Pathway Capstone Course Curriculum and Pacing Guide. This pacing guide will allow educators to …

Reducing Carbon Emissions With Returned Concrete, John M. Maxwell Jr.

Construction Management

The concrete industry is one of the most energy-intensive sectors of construction. Specifically, the cement production aspect is the most energy intensive, and produces the most carbon emissions. Concrete, a material ubiquitous with nearly every facet of construction; certain types of structures are composed of nearly all concrete. Production of cement is one of the biggest contributors to emissions within the industry. There have been initiatives to reduce or offset emissions from this process, through things like carbon capture, and the purchase of carbon or emissions credits. The objective of this paper was to investigate a new method of carbon …

Exploring Podcasting As A Medium For Sharing Modern Issues With College-Age Demographics, Arabel Grey Meyer

Journalism

This paper examines the medium of podcasting and creating a personal brand through this medium. While analog forms of broadcast media such as television and radio were some of the most common sources of the public’s information until around the 1960s, technological advances and the creation of the internet drastically changed the way that the public absorbs and accesses its information. Media serves to provide several key roles in our society: entertainment, education, providing a platform to discuss issues, and serving the role of a watchdog for institutions and governments (2016). Podcasting, as a modern media form that has become …

Academic Senate - Minutes, 4/16/2024, Academic Senate

Academic Senate Minutes

No abstract provided.

Teaching Citation Politics Through Literature Review Topographies: Towards Cultivating Relational Writing Practices, Mairi Mcdermott

Feminist Pedagogy

Feminism teaches how power works and circulates through our often-unquestioned everyday practices. Since becoming a professor, I have committed myself to this feminist teaching by demystifying--and reimagining--habituated practices, relations, and expectations in higher education that produce and are produced through cis-hetero-patriarchal capitalist White supremacy. Since literature reviews and citation practices are core materials scholars work with, I invite doctoral students to consider different ways these materials can be engaged in efforts to craft transgressive knowledges and worlds through our research. In this article, I describe an assignment designed to disrupt hegemonic patriarchal inheritances in the conventions of writing literature reviews …

Executive Committee - Minutes, 4/2/2024, Academic Senate

Academic Senate Minutes

No abstract provided.

Executive Committee - Agenda 4/2/2024, Academic Senate

Academic Senate Agendas

No abstract provided.

American Media And Memories: How Visual Media Tells The History Of The World Wars In The 21st Century, Julian A. Rispaud

History

This paper examines how fictional digital media–film, television, and digital games–have both mirrored and influenced the American popular memory of the World Wars, establishing how visual media in the last 25 years has disseminated distinct historical themes and narratives to American audiences. Examining both World Wars together allow us to witness historical narratives of WWI and WWII intersecting across many works of media, applying critical elements of one conflict's memory to the other. This is accomplished through the process of historical thematic dissemination, through with creators off all three types of visual media pay homage to or draw on historical …

Exploration On Lysing Microalgae Using Pulsed Electric Fields, Fereshteh A. Bunk

Physics

With a dangerously and rapidly changing climate [1], people globally are desperate to reduce CO2 emissions and protect our environment as evidenced by global initiatives such as the United Nations’ Paris Agreement [2]. Traditional fossil fuel extraction and combustion was responsible for 74% of U.S. greenhouse gas emissions in 2019, which contributes to climate change, ocean acidification, extreme weather events, sea level rise, pollution, and health issues which contributed to 350,000 premature deaths in the U.S. in 2018 [3]. This motivates the search for alternative, more sustainable fuel production. There have been many new, more sustainable solutions to traditional fossil …

Hunting Without Grounds: Why Hsiao Fails To Justify Trophy Hunting, Kyle York

Between the Species

Trophy hunting is probably bad. Timothy Hsiao (2020), however, thinks that it isn’t bad. This is because he thinks that animals lack moral status. Other philosophers have tried to argue against the theoretical grounds upon which Hsiao denies moral status to animals. I suggest that Hsiao’s arguments for trophy hunting should be rejected simply because they have extremely unintuitive implications. They imply that it would be fine to play ‘panda-ball,’ a variation of baseball where players use panda cubs as bases and balls, or even to blow up planets full of panda cubs just for the fun of it. As …

Design And Test The Effectiveness Of Interpretive Signs Using Eye Tracking And Biometric Data, Hadara Gordon, Wendy Miyazaki

Baker/Koob Endowments Awarded Projects

Recreational trails on forested lands should satisfy the needs of recreationists, safeguard important habitats, and maintain the natural environment (Kortenkamp et al., 2021). Appropriate management is critical because of the increasing number of visitors. Signs are a cost-effective method to reduce the negative impacts on visitors and enhance visitor experiences (Brown et al., 2010). This research aimed to investigate how visitors pay attention to signs, view the trail surrounded by trees and behave in a natural space.

Comparison Of Scanning Electron Microscopy And Confocal Laser Microscopy For Tissue Surface Roughness Characterization, Tarnvir Dhaliwal

Master's Theses

It was found that the measurements captured by confocal microscopy and scanning electron microscopy had a statistically significant difference for bovine tissue. There was not a statistically significant for porcine and poultry tissue.

The intent of the study is to perform a comparative study to examine efficacy of two distinct technologies for a singular purpose: tissue surface roughness characterization. The two technologies compared are a confocal reflectance microscope and a scanning electron microscope. The comparison was made by comparing two surface roughness parameters [Ra and Rq] within ImageJ.

The study examined three different animal species [porcine, bovine, and poultry] to …

Development Of An In Vitro 3-Dimensional Co-Culture Human Colorectal Cancer Model In Microfluidic Devices, Abby Jens

Master's Theses

Colorectal cancer is the second most common cause of cancer-related deaths in the United States, with the relative 5-year survival rate for distant stage cancer being only 14%. The most common treatment for colorectal cancer is with chemotherapeutic drugs; however, the discovery of these drugs is costly, time-consuming, and often requires the use of animal models that do not yield results that translate to clinical trials. Due to these shortcomings, researchers seek to develop physiologically relevant in vitro tumor models that more accurately mimic the tumor microenvironment for cheaper and faster high-throughput drug screening. The aim of this research was …

Beyond City Limits: A Case Study On The Sustainability Practices At Austin City Limits Music Festival, Molly Dengler

Experience Industry Management

As sustainably efforts have increased throughout the events industry, Austin City Limits (ACL) Music Festival has taken initiative to incorporate a number of their own sustainable efforts into this annual event. The purpose of this study was to examine the three pillars of sustainability within Austin City Limits Music Festival. Research for this study was conducted using a case study guide, developed by the researcher, to assess the sustainability practices currently being implemented within the ACL Festival. The results of this study indicate that Austin City Limits Music Festival utilized effective sustainability practices, including waste management programs, diverse opportunities, and …

Development Of A Cell Culture Incubator Capable Of Providing A Hypoxic Environment, Grant Austin Coe

Master's Theses

In order to perform more robust and physiologically relevant research, the Microphysiological Systems laboratory required a method of culturing cells where the level of oxygen could be adjusted. To fulfill this need, I designed and manufactured a hypoxic cell culture incubator. I employed a Quality Function Deployment to understand the customer requirements and convert them into engineering specifications. Based on these specifications, I created various conceptual designs. I evaluated the conceptual designs as compared to existing products and decided to move forward with the control system separated from a small, standard chamber. I developed the circuitry schematics for the temperature …

The Use Of Biomimicry In Urban Planning And Design, Cole Sorensen

City and Regional Planning

No abstract provided.

Water Quality Assessment For San Luis Obispo Creek And Stenner Creek, Brent Flemmer

Master of Science in Environmental Sciences and Management Projects

Water quality was assessed in five stream segments in San Luis Obispo and Stenner Creeks in Spring of 2023. Two of the five sites were located along San Luis Obispo Creek, and three located along Stenner Creek. Criteria to evaluate these aquatic systems was provided by the Standard Operating Procedures of the Surface Water Ambient Monitoring Program, formulated by the State Water Resources Control Board. These procedures describe the methodology surrounding the collection of chemical, physical, and biological parameters of stream systems; streamflow, substrate, flow habitat, chemical water quality, and benthic macroinvertebrates are some of the criteria collected that allows …

Effects Of Anthropogenic Noise On The Provisioning Behavior Of Western Bluebirds And Artificial Light At Night On Nestling Development, Kerstin H. Ozkan

Master's Theses

Sensory environments are rapidly changing due to increased human activity in urban and non-urban areas alike. For instance, background sounds can interfere with parent-offspring communication and mask cues reflective of predation risk, resulting in elevated vigilance at the cost of provisioning. In chapter 1, we studied nestling provisioning behavior among Western Bluebirds (Sialia mexicana) in response to short-term (1 hr) and long-term (continuous exposure throughout nesting period) noise exposure. Provisioning rates were lower at nests exposed to short-term experimental traffic noise compared to exposure to ambient background sounds. Trial order strongly influenced provisioning behavior, with the decline in …

Lemur Enclosure, Joshua Mancio, Justin Krietzberg

Construction Management

Zoo-to-You, a local wildlife conservation zoo, proposed a project to construct a new shelter for their lemurs due to the inadequacy of protection for extreme heat or cold weather of their previous enclosure. With three lemurs in residence, the zoo sought to create a spacious and insulated shelter that would provide protection from the elements while allowing connectivity to the adjacent enclosures. Situated amidst two existing circular cages with a gap in between, the project presented unique site conditions on a concrete slab. The scope of the project encompassed estimating, design, material procurement, build-out, and owner turnover, with the objective …