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Hypoxia-Sensitive Gene Expression In The Gastrocnemius Muscle Following Chronic Hind Limb Ischemia, Andrew Tilton

Biological Sciences

Chronic ischemia, caused by the formation atherosclerotic plaque occlusions in major conduit arteries, is the leading cause of morbidity and mortality in western societies. Vascular remodeling can help compensate for the adverse effects of atherosclerotic plaque formation. Vascular remodeling relies heavily on vascular endothelial growth factor (VEGF), a critical protein that contributes to all forms of vascular formation and remodeling including angiogenesis, arteriogenesisand vasculogenesis. VEGF itself is up-regulated by the transcription factor, hypoxia inducible factor 1 alpha (HIF-1α), which becomes activated in low oxygen environments.

Through the use of animal chronic hindlimb ischemia models, these genes can be evaluated as …

Tissue Engineering A Blood Vessel Mimic While Monitoring Contamination Through Sterility Assurance Testing, Navid Djassemi

Master's Theses

Tissue Engineering A Blood Vessel Mimic While Monitoring Contamination Through Sterility Assurance Testing

Navid Djassemi

Tissue engineering blood vessel mimics has been proposed as a method to analyze the endothelial cell response to intravascular devices that are used in today’s clinical settings for the treatment of cardiovascular disease. Thus, the development of in vitro blood vessel mimics (BVMs) in Cal Poly’s Tissue Engineering Lab has introduced the possibility of assessing the characteristics of cellular response to past, present, and future intravascular devices that aim at treating coronary artery disease.

This thesis aimed at improving the methods and procedures utilized in …

South El Camino Real Vision Plan, City Of Atascadero, Spring 2012, Crp 553 Project Planning Lab

City and Regional Planning Studios and Projects

No abstract provided.

The Double Pendulum: Construction And Exploration, Benjamin J. Knudson

Physics

The exploration of a nonlinear mechanical system, the Double Pendulum, a physical pendulum on the end of a physical pendulum, using analytic and experimental approaches. Also included discussion of the design and construction of the Double Pendulum apparatus to work with Vernier LabPro and LoggerPro. The apparatus outputs live data of the angles to a LoggerPro which collects and produces time evolution graphs as well as a corresponding animation lending itself to comparison with theoretical models. Normal mode frequencies are found both analytically and experimentally for the the general (real) double pendulum. Examples of both simple (periodic) and complex (chaotic) …

Parental Diet And Risk Of Retinoblastoma Resulting From New Germline Rb1 Mutation, Greta R. Bunin, Marilyn Tseng, Yimei Li, Anna T. Meadows, Arupa Ganguly

Kinesiology and Public Health

We conducted a case–control study of sporadic bilateral retinoblastoma, which results from a new germline RB1 mutation, to investigate the role of parents' diet before their child's conception. Parents of 206 cases from nine North American institutions and 269 controls participated; of these, fathers of 184 cases and 223 controls and mothers of 204 cases and 260 controls answered a food frequency questionnaire administered by phone about their diet in the year before the child's conception. Cases provided DNA for RB1 mutation testing. We assessed parents' diet by examining 19 food groups. Father's intake of dairy products and fruit was …

A Study Of Faculty Data Curation Behaviors And Attitudes At A Teaching-Centered University, Jeanine Marie Scaramozzino, Marisa L. Ramírez, Karen J. Mcgaughey

Library Scholarship

Academic libraries need reliable information on researcher data needs, data curation practices and attitudes in order to identify and craft appropriate services that support outreach and teaching. This paper describes information gathered from a survey distributed to the College of Science and Mathematics faculty at California Polytechnic State University, San Luis Obispo (Cal Poly), a Master’s-granting, teaching-centered institution. There was a 60%+ response rate to the survey. The survey results provided insight into the science researchers’ data curation awareness, behaviors and attitudes, and what needs they exhibited for services and education regarding maintenance and management of data. It is important …

Development Of In Vitro Tissue Engineered Blood Vessel Mimics In Complex Geometries For Coronary Stent Testing, Robert Dalton Chavez

Master's Theses

Coronary heart disease is the leading cause of death in the United States and occurs when plaque occludes coronary arteries. Coronary stents, which may be used to treat coronary occlusions, are small metal tubes that are implanted in coronary arteries to restore blood flow. After stent implantation, endothelial cells grow over the stent so that blood contacts the endothelial cells instead of the stent surface; this event is known as re-endothelialization. Re-endothelialization prevents blood from clotting on the stent surface and is a good predictor of stent success. Blood vessel mimics (BVMs) are in vitro tissue engineered models of human …

Characterization Of Tight Junction Formation In An In-Vitro Model Of The Blood-Brain Barrier, Michael Robert Machado

Master's Theses

Active and passive transport of substances between the microcirculation in the brain and the central nervous system is regulated by the Blood-Brain Barrier (BBB). This barrier allows for chronic and acute modulation of the CNS microenvironment, and protects the brain from potentially noxious compounds carried in the circulatory system. In-vitro modeling of the BBB has become the target of much research over the past decade, as there are many unanswered questions regarding modulations in the permeability of this barrier. Additionally, the development of a practical and inexpensive model of the BBB would facilitate a much more efficient drug development process. …

Development And Characterization Of An In-House Custom Bioreactor For The Cultivation Of A Tissue Engineered Blood-Brain Barrier, Amin Hadi Mirzaaghaeian

Master's Theses

The development of treatments for neurological disorders such as Alzheimer’s and Parkinson’s disease begins by understanding what these diseases affect and the consequences of further manifestation. One particular region where these diseases can produce substantial problems is the blood-brain barrier (BBB). The BBB is the selective diffusion barrier between the circulating blood and the brain. The barrier’s main function is to maintain CNS homeostasis and protect the brain from the extracellular environment. The progression of BBB research has advanced to the point where many have modeled the BBB in vitro with aims of further characterizing and testing the barrier. Particularly, …

Factors Influencing Landslides In The Bittercreek Wildlife Refuge, David Mceachern

Natural Resources Management and Environmental Sciences

No abstract provided.

Feasibility And Economic Viability Of Establishing A Wine Grape Vineyard In Moraga, Ca, Vincent Joseph Bruzzone

Agribusiness

No abstract provided.

A Demand Analysis For The New Dow Agrosciences Insecticide, Sulfoxaflor, Among California Pest Control Advisors, Andre Lima Alves

Agribusiness

No abstract provided.

A Marketing Plan For Sycamore Flats Hay Harvesting, Allen William Bengston Jr.

Agribusiness

No abstract provided.

Capturing History From The Cal Poly College Of Agriculture, Food And Environmental Sciences Since 1950, Carrie Isaacson

Agricultural Education and Communication

No abstract provided.

Chaosocial - A Social Media Platform For Social Movements, Nathanael Hughes

Liberal Arts and Engineering Studies

Recent Social Movements have increasingly used social media as a driving component in recruiting, developing the cause, and mobilizing people to action. Chaosocial is a web application that provides a layer of organization over social media, allowing organizations traditionally limited in ability to leverage social media to use it to strengthen their social movements.

Sustainability Practices For Special Events On The Central Coast Of California, Cara Richards

Recreation, Parks, and Tourism Administration

With the ever growing number of planned events around the world and the vast number of attendees, comes the potential to negatively impact the environment. The event industry is perfectly suited to reduce this environmental impact by incorporating sustainable practices into their special events. The purpose of this study was to assess the use of sustainable practices by event planners on the Central Coast of California. This study was conducted through the online survey application Zoomerang.com. The results of this survey indicate that 80% of respondents understand the importance of sustainability and15% were uncertain if sustainability is an important factor …

Gender Preferences In Wine Marketing, Cristina Lombardo

Agribusiness

When purchasing a bottle of wine, the label is the consumer’s first impression. Previous research about how different target markets react to label design and information cues have proven to have significant differences. This study was undertaken to determine how men and women view these features and cues differently. An online survey was submitted to 100 potential respondents with 69 surveys returned for analysis. Various statistical data analysis was conducted and the results are presented in this report. There was a significant difference across the genders for a label that “is colorful” and for an “organic” information cue. It is …

An Analysis Of Change Of Major Behavior Of Cal Poly Students, Logan Lossing

Statistics

No abstract provided.

Seasonality Of Infant Feeding Practices In Three Brazilian Birth Cohorts, David A. González-Chica, Helen Gonçalves, Aydin Nazmi, Iná S. Santos, Aluísio J. D. Barros, Alicia Matijasevich, Cesar G. Victora

Food Science and Nutrition

Background We assessed the influence of season of birth on duration of breastfeeding and other feeding patterns in three population-based birth cohort studies in the city of Pelotas, Southern Brazil.

Methods In 1982, 1993 and 2004, all hospital-born children in the city were enrolled in three cohort studies (n =  5914, 5249 and 4287, respectively). Children and their mothers were periodically visited in the first 2 years of life, to collect information on the duration of breastfeeding and the ages at which different types of foods were introduced on a regular basis. Two independent variables were studied: month of …

Evaluation Of Corrosion Properties For Use Of Az31b In Bioabsorbable Stents And In Vivo Corrosion Rate Prediction Using Fea, Jared Vidales, Austin Schader, Jenna Jerman, Michael Turovskiy

Materials Engineering

AZ31B was heat treated to evoke more controlled and uniform corrosion. 1/16” diameter AZ31B wire was cut into six samples each 1” long. The samples underwent heat treatments following ASTM B661-06. Samples were weighed and placed into three different in vitro environments. In the first scenario two samples of each heat treatment were individually placed in 50 ml of saline solution at 0.9% sodium, in a static test tube at 37°C temperature. Two samples were placed in 100 ml of 0.9% saline solution in a 250 ml stirring beaker with an average whirlpool depth of 1”. Two of each sample …

Artificial Alveolar-Capillary Membrane On A Microchip, Keith Male

Materials Engineering

A microfluidic device was synthesized out of polydimethyl siloxane (PDMS) to simulate the structure of the alveolar-capillary interface of the human lung. Soft lithography techniques were used to build a mold structure out of SU-8 epoxy at heights ranging from 30µm to 110 µm on a silicon substrate, with the 70 µm structure working the best. A mixture of 10:1 Sylgard 184 elastomer was then cast using the mold, and cured at a temperature of 80^oC. For the porous membrane, the PDMS was spun on at 6000rpm for 30 seconds using a spin coater to produce a membrane …

Design And Development Of An Interactive Materials-Based Learning Kit For K-4 Grade Levels, Thomas Agasid, Santiago Caceres, James Woodhead

Materials Engineering

The Materials Safari Adventure kit was designed to help introduce basic materials concepts to young audiences in kindergarten through fourth grade levels. The primary goal of this project was to design a tool to spark an interest in materials science for young children, while revealing the field of materials science to parents and educators. The final kit design incorporates a safari theme to encourage imagination and promote self-directed learning through the interaction with materials. Materials were selected to showcase a range of properties within three materials classes: metals, polymers, and natural woods. A total of 9 materials were chosen for …

The Mitigation Of Eutrophication Using Microporous Polymer Membranes To Control Algae Growth, Christopher R. Riley

Materials Engineering

A system was designed to mitigate the accelerated process of anthropogenic eutrophication. This system aimed to contain Chlorella Vulgaris microalgae cells within an enclosed polymer membrane pouch while allowing for water and nutrients to diffuse through the pouch. As a test model, a 10 gallon aquarium was partitioned into three sections using polycarbonate membranes with 1 micron pore diameters. Each section was then gradually filled with a deionized water and Bristol solution recommended for microalgae growth. Phosphate and nitrate were added to Section A of the aquarium and allowed to diffuse throughout the tank. A water pump was used to …

"Ag Ed 539 - Graduate Internship Project", Diane B. Friend

Agricultural Education: Graduate Internship Reports

This internship report contains documented evidence required in meeting the quality criteria used to evaluate Community College Programs. These criteria were established by the Agriculture/Natural Resources Advisory Committee and are used to evaluate Community Colleges throughout California. In addition to documented evidence, the internship report also includes a special project on Student Support Programs at College of the Sequoias. The project documents the development and implementation of a viable, organized and structured Ag Business Club to support student leadership programs.

How To Build A Nixie Clock, Shepherd Darquea

Physics

No abstract provided.

Like Laws And Sausages: The Tale Of A Mere Portion Of The Process To Develop The South Broad Street Corridor Plan, Amy R. Lopez

Master's Theses

The processes to develop community plans share certain standard activities and stages while remaining distinctive and without pre-scripted procedures. This study documents the process that yielded the South Broad Street Corridor Plan June 2012 draft. The objective is to present the decision-making processes and their connections to the final plan document along with the plan document itself.

Network Channel Visualizing Simulator: A Real-Time, 3d, Interactive Network Simulation Platform, Sean Michael Forsberg

Master's Theses

With a focus of always being connected, it's become typical for laptops and mobile devices to include multiple wireless network devices. Though the additional network devices have created mobility and versatility of how a user is connected, it is common for only one to be active at any given time. While likely that new mesh protocols will help maximize connectivity and power consumption by utilizing lower-power multi-hop techniques, it is still difficult to visualize these protocols due to the complexity created by each node's simple choices. Further challenges are presented by the variety of network devices which share frequency ranges …

Hearst Hydroelectric Generation Facility, Anthony Schifano, Richard Wright, Nick Buchanan, Corey Nakai, Joshua Rutheiser

Electrical Engineering

This project proposes a power plant design that provides a supplemental source of electricity for appliances, machinery, and lighting at Hearst Castle and Ranch. The design concept includes a turbine-generator combination to convert kinetic and gravitational potential energy from the existing water distribution system to electrical energy: also known as a hydroelectric plant. The electrical distribution system from the plant to the local grid takes advantage of power flow techniques utilized in current research and industry.

Printed Electroluminescent Display, Christopher (Chris) James Nixon, Veronica Kopp

Electrical Engineering

Electroluminescent displays are part of an emerging technology known as printed electronics. Most identify printed electronics with purely electronic purposes such as the Radio frequency identification (RFID). Now the electronics and graphic communication industries have come together to create of new forms of products that interact with customers. Flexible, electronic circuits use functional inks and traditional printing methods such as screen printing, gravure, and inkjet. Printed electronics are perfect for low performance applications, such as displays, labels, clothing and batteries. This paper focuses on creating an interactive electroluminescent (EL) display. In selling a product, displays are important because most customers …

3d Digital Modeling For Urban Design + Planning, Emmanuel Velazco

City and Regional Planning

Cities throughout the country face a number of challenges in dealing with the changing development needs of the 21st century. In urban planning, the fusion of social, environmental, political, economic, and functional considerations are required. Today, local, state, and federal governments are experiencing an economic downturn, making resources scarce to plan for smarter development, attain greater public interest, and economic revival.

The primary objective of this project is to provide innovative solutions in city and regional planning using software applications, such as Google SketchUp, that enable assessment of various urban design projects. A second objective was to create a 3D …