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Maternal High-Salt Diet During Pregnancy In Sprague Dawley Rats Programs Exaggerated Stress-Induced Blood Pressure And Heart Rate Responses In Adult Female Offspring, Summer Hayes King Aug 2007

Maternal High-Salt Diet During Pregnancy In Sprague Dawley Rats Programs Exaggerated Stress-Induced Blood Pressure And Heart Rate Responses In Adult Female Offspring, Summer Hayes King

Theses and Dissertations

The prenatal environment has been shown to have lasting effects on cardiovascular health. In the present study, pregnant rats were fed a 0.7% NaCl normal salt (NS) diet or an 8% NaCl high salt (HS) diet throughout pregnancy. Adult offspring were fitted with radiotelemetry probes to continuously measure blood pressure and heart rate. Rats were placed in restraining cages to test for a programmed acute stress hyperresponsiveness. Offspring were challenged with HS diet for one week to determine if blood pressure salt sensitivity had been programmed by the prenatal HS diet. Animals were killed following resting and acute stress conditions, …

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Associations Between Shyness And Internalizing Behaviors, Externalizing Behaviors, And Relationships During Emerging Adulthood, Larry J. Nelson, Laura M. Padilla-Walker, Sarah Badger, Carolyn Mcnamara Barry, Jason S. Carroll, Stephanie D. Madsen Aug 2007

Associations Between Shyness And Internalizing Behaviors, Externalizing Behaviors, And Relationships During Emerging Adulthood, Larry J. Nelson, Laura M. Padilla-Walker, Sarah Badger, Carolyn Mcnamara Barry, Jason S. Carroll, Stephanie D. Madsen

Faculty Publications

Many studies have documented the ways in which shyness can be a barrier to personal well-being and social adjustment throughout childhood and adolescence; however, less is known regarding shyness in emerging adulthood. Shyness as experienced during emerging adulthood may continue to be a risk factor for successful development. The purpose of this study was to compare shy emerging adults with their non-shy peers in (a) internalizing behaviors, (b) externalizing behaviors, and (c) close relationships. Participants included 813 undergraduate students (500 women, 313 men) from a number of locations across the United States. Results showed that relatively shy emerging adults, both …

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Compartmentalization Of Hiv-1 In The Secondary Lymphoid Tissues, James Peter Gregson Aug 2007

Compartmentalization Of Hiv-1 In The Secondary Lymphoid Tissues, James Peter Gregson

Theses and Dissertations

Follicular dendritic cells (FDCs) reside in the lymphoid follicles of the secondary lymphoid tissues (sLTs). Following the infection of an individual with human immunodeficiency virus type 1 (HIV-1), viral particles are trapped in massive quantities on the surfaces of FDCs. HIV-1 viral compartments are cell types or tissues between which there is a restriction of virus flow. Compartmentalization of HIV-1 creates numerous sites within the body in which the virus can undergo independent evolution, giving rise to a more diverse total viral population. Given the sessile nature of the FDC, I hypothesized that contrary to common assumptions, FDC-trapped HIV-1 is …

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Assessment Of Genetic Diversity In The Usda And Cip-Fao International Nursery Collections Of Quinoa (Chenopodium Quinoa Willd.) Using Microsatellite Markers, S. A. Christensen, D. B. Pratt, C. Pratt, P. T. Nelson, M. R. Stevens, Eric N. Jellen, Craig E. Coleman, Daniel J. Fairbanks, A. Bonifacio, Michael J. Maughan Aug 2007

Assessment Of Genetic Diversity In The Usda And Cip-Fao International Nursery Collections Of Quinoa (Chenopodium Quinoa Willd.) Using Microsatellite Markers, S. A. Christensen, D. B. Pratt, C. Pratt, P. T. Nelson, M. R. Stevens, Eric N. Jellen, Craig E. Coleman, Daniel J. Fairbanks, A. Bonifacio, Michael J. Maughan

Faculty Publications

Quinoa (Chenopodium quinoa Willd.) is a staple food crop for millions of impoverished rural inhabitants of Andean South America where it has been cultivated for millennia. Interest in quinoa, due largely to its superior nutritional characteristics, is fuelling a growing export market and has led to an increased focus on genetic research and the development of quinoa breeding programmes throughout South America. The success of these breeding programmes will rely heavily on the development of core germplasm collections and germplasm conservation. We report the development of a set of fluorescence-tagged microsatellite molecular markers that can be used to characterize genetic …

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Longitudinal Course Of Body Dissatisfaction In Undergraduate Females At Brigham Young University, Joy Wiechmann Jul 2007

Longitudinal Course Of Body Dissatisfaction In Undergraduate Females At Brigham Young University, Joy Wiechmann

Theses and Dissertations

This research project examined the longitudinal course of body dissatisfaction among undergraduate females at Brigham Young University (BYU) using the Body Satisfaction Questionnaire (BSQ).The research also examined what percentage of undergraduate females have BSQ ratings in the clinically significant range and whether body dissatisfaction ratings varied based on the environment in which the student lived. Results indicate that no significant change in body dissatisfaction occurred over time, nor did living environment appear to play a role in BSQ scores. Results also showed that at any given time over 34% of women on BYU campus have BSQ scores in the clinically …

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Thomas Carlyle, Fascism, And Frederick: From Victorian Prophet To Fascist Ideologue, Jonathon C. Mccollum Jul 2007

Thomas Carlyle, Fascism, And Frederick: From Victorian Prophet To Fascist Ideologue, Jonathon C. Mccollum

Theses and Dissertations

The Victorian Author Thomas Carlyle was in his day a meteoric voice but his popularity and reputation declined significantly due in part to his link to fascism. In the politically polarized era of the Second World War, academics and propagandists dubbed him a fascist or Nazi in both defamation and approval. Fascist scholars pressed Carlyle into service as a progenitor and prophet of their respective totalitarian regimes. Adolf Hitler, in his final days, assuaged his fears of his imminent fall with readings from Carlyle's History of Frederick the Great. This fascist connection to the once esteemed “Sage of Chelsea” marks …

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The Relationship Between Family Composition And Social Behavior For Students With Mild Disabilities In Schools, Amanda Clark Jul 2007

The Relationship Between Family Composition And Social Behavior For Students With Mild Disabilities In Schools, Amanda Clark

Theses and Dissertations

Previous research identifies significant differences in children's problem behavior across various family structures, particularly noting more challenging behaviors in children from single parent families. Utilizing a pre-existing data set of Behavioral Objective Sequence (BOS) scores, this study investigated teacher ratings of social behavioral skills in students with mild disabilities, focusing on differences between groups of students from a variety of family compositions. Results indicated no significant difference in social behavioral skills among children from different family groups, taking into account the student's age. The covariate of age was significant on each of six BOS subscales, suggesting that children develop and …

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Contributions Of Family Leisure To Family Functioning Among Single-Parent Families, Laurel Beth Hornberger Jul 2007

Contributions Of Family Leisure To Family Functioning Among Single-Parent Families, Laurel Beth Hornberger

Theses and Dissertations

The purpose of this study was to examine the contribution of family leisure involvement to the family functioning of single-parent families among a large national representative sample. Two samples were gathered. The single-parent sample consisted of 384 families (384 parents and 384 youth). The dual-parent sample consisted of 495 families (495 parents and 495 youth). Data were analyzed from the parent, youth, and family perspective using two instruments. The Family Adaptability and Cohesion Scale (FACES II) was used to measure family functioning and the Family Leisure Activity Profile (FLAP) was used to measure family leisure involvement. Blocked multiple regression analysis …

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An 828 Year Streamflow Reconstruction For The Jordan River Drainage Basin Of Northern Utah, Bryan P. Tikalsky Jul 2007

An 828 Year Streamflow Reconstruction For The Jordan River Drainage Basin Of Northern Utah, Bryan P. Tikalsky

Theses and Dissertations

Bryan Tikalsky Department of Geography Master of Science Mountain water resources are essential to those living along the Salt Lake City urban corridor. Water resource planners base their policy on twentieth century climate conditions and streamflow records. Often these records only account for a small amount of the natural variability in streamflow and climate. By utilizing dendrochronology this study seeks to better understand variability of streamflow in the Jordan River Drainage Basin over the last 828 years. A GIS model was used to identify potential sampling sites where tree growth would be sensitive to climate and factors affecting stream run-off. …

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Handling And Analysis Of Public Comments In Natural Resource Planning, Lisette Borchert Thurgood Jul 2007

Handling And Analysis Of Public Comments In Natural Resource Planning, Lisette Borchert Thurgood

Theses and Dissertations

The National Environmental Policy Act (NEPA) of 1970 required public input in any federal planning process or action. Consequently, natural resource planning can be characterized as more of a complex situation in recent years due to the increasing involvement of the number of constituents who want to be heard. Likewise, the public wants to know their ideas have been heard and considered. Unfortunately, there is very little information available which identifies how the BLM handles and analyzes public scoping comments that are required under NEPA. The purpose of this research is to identify the handling and analysis methodology used by …

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Holmes, Alice, And Ezeulu: Western Rationality In The Context Of British Colonialism And Western Modernity, Andrew B. Schultz Jul 2007

Holmes, Alice, And Ezeulu: Western Rationality In The Context Of British Colonialism And Western Modernity, Andrew B. Schultz

Theses and Dissertations

This thesis examines Western rationality, contextualizing that subject in British colonialism and Western modernity. Using Scott Lash's description of academic characterizations of modernity, I explore the “high" modernity of the social sciences represented in the books Alice's Adventures in Wonderland by Lewis Carroll and The Hound of the Baskervilles by Arthur Conan Doyle. I then explore the cultural studies critique of that characterization of modernity in the book Arrow of God by Chinua Achebe. Using the theory of Jean Francois Lyotard, Martin Heidegger, and Theodor Adorno, I look at Western rationality through its manifestation in British colonialism. I argue that …

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Development Of Informative Priors In Microarray Studies, Kassandra M. Fronczyk Jul 2007

Development Of Informative Priors In Microarray Studies, Kassandra M. Fronczyk

Theses and Dissertations

Microarrays measure the abundance of DNA transcripts for thousands of gene sequences, simultaneously facilitating genomic comparisons across tissue types or disease status. These experiments are used to understand fundamental aspects of growth and development and to explore the underlying genetic causes of many diseases. The data from most microarray studies are found in open-access online databases. Bayesian models are ideal for the analysis of microarray data because of their ability to integrate prior information; however, most current Bayesian analyses use empirical or flat priors. We present a Perl script to build an informative prior by mining online databases for similar …

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Amp-Activated Protein Kinase Kinase Activity And Phosphorylation Of Amp-Activated Protein Kinase In Contracting Muscle Of Sedentary And Endurance Trained Rats, Denise Hurst Jul 2007

Amp-Activated Protein Kinase Kinase Activity And Phosphorylation Of Amp-Activated Protein Kinase In Contracting Muscle Of Sedentary And Endurance Trained Rats, Denise Hurst

Theses and Dissertations

This study was designed to examine activity of AMP-activated protein kinase kinase (AMPKK) and AMP-activated protein kinase (AMPK) in muscles from control (C) and endurance trained (T) rats. Rats were trained 5 days/wk, 2 hr/d for 8 wks at a final intensity of 32 m/min up a 15% grade with 30 second sprints at 52 m/min every 10 min. Gastrocnemius muscles were stimulated in situ in T and C rats for 5 min at frequencies of 0.4/sec and 1/sec. Gastrocnemius LKB1 protein, a putative component of the AMPKK complex (LKB1, STRAD, and MO25), increased approximately 2-fold in response to training. …

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Development Of Chemomechanical Functionalization And Nanografting On Silicon Surfaces, Michael Vernon Lee Jul 2007

Development Of Chemomechanical Functionalization And Nanografting On Silicon Surfaces, Michael Vernon Lee

Theses and Dissertations

Progress in chemomechanical functionalization was made by investigating the binding of molecules and surface coverage on the silicon surface, demonstrating functionalization of silicon with gases by chemomechanical means, analyzing atomic force microscopy probe tip wear in atomic force microscopy (AFM) chemomechanical nanografting, combining chemomechanical functionalization and nanografting to pattern silicon with an atomic force microscope, and extending chemomechanical nanografting to silicon dioxide. Molecular mechanics of alkenes and alkynes bound to Si(001)-2x1 as a model of chemomechanically functionalized surfaces indicated that complete coverage is energetically favorable and becomes more favorable for longer chain species. Scribing a silicon surface in the presence …

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Palmitoylation And Oxidation Of The Cysteine Rich Region Of Snap-25 And Their Effects On Protein Interactions, Derek Luberli Martinez Jul 2007

Palmitoylation And Oxidation Of The Cysteine Rich Region Of Snap-25 And Their Effects On Protein Interactions, Derek Luberli Martinez

Theses and Dissertations

Neurons depend upon neurotransmitter release through regulated exocytosis to accomplish the immense processing performed within the central nervous system. The SNARE hypothesis points to a family of proteins that are thought to enable the membrane fusion that leads to exocytosis. The secondary structure of SNAP-25 is unique among SNARE proteins in that it has two alpha helical SNARE motifs and a cysteine rich (C85, C88, C90, C92) membrane interacting region but notransmembrane domain. The cysteines may be modified by palmitoylation or oxidation but the role of these modifications in vivo is not well understood. Our goal is to elucidate possible …

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Cloning And Characterization Of The Salt Overly Sensitive 1 (Sos1) Gene In Chenopodium Quinoa Willd., Taylor Brian Turner Jul 2007

Cloning And Characterization Of The Salt Overly Sensitive 1 (Sos1) Gene In Chenopodium Quinoa Willd., Taylor Brian Turner

Theses and Dissertations

Salt tolerance is a commercially important trait that affects plant species around the globe. Cellular response to saline environments is a well studied but complex system that is far from being completely understood. The SALT OVERLY SENSITIVE 1 (SOS1) gene is a critical component of salt tolerance in many species, encoding a plasma membrane Na+/H+ antiporter that plays an important role in germination and growth in saline environments. Here we report a preliminary investigation of salt tolerance in quinoa (Chenopodium quinoa Willd.). Quinoa is a halophytic grain crop of the Chenopodiaceae family with impressive nutritional content and an increasing world-wide …

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Synthesis Of Resveratrol And Its Analogs, Phase-Transfer Catalyzed Asymmetric Glycolate Aldol Reaction, And Total Synthesis Of 8,9-Methylamido-Geldanamycin, Jing Liu Jul 2007

Synthesis Of Resveratrol And Its Analogs, Phase-Transfer Catalyzed Asymmetric Glycolate Aldol Reaction, And Total Synthesis Of 8,9-Methylamido-Geldanamycin, Jing Liu

Theses and Dissertations

The phytoalexin resveratrol and its acetyl analogs have been made using a decarbonylative Heck reaction. The acid chloride derived from 3,5-dihydroxybenzoic acid was coupled with suitable protected 4-hydroxystyrene in the presence of palladium acetate and N,N-bis-(2,6-diisopropylphenyl)-4,5-dihydro imidazolium chloride to give the substituted stilbene in good yield as the key step. Human HL-60 cell assays showed the 4'-acetyl resveratrol variant improved activity (ED50 17 μM) relative to resveratrol (24 μM). Cinchona phase-transfer catalysts (PTC) were developed for glycolate aldol reactions to give differentially protected 1,2-diol products. Silyl enol ether of diphenylmethoxy-2,5-dimethoxyacetophenone reacted to generate benzhydryl-protected products. O-Allyl trifluorobenzyl cinchonium hydrodifluoride (20 …

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Statistical Considerations In Designing For Biomarker Detection, Trenton C. Pulsipher Jul 2007

Statistical Considerations In Designing For Biomarker Detection, Trenton C. Pulsipher

Theses and Dissertations

The purpose of this project is to develop a statistical method for use in rapid detection of biological agents using portable gas chromatography mass spectrometry (GC/MS) devices. Of particular interest is 2,6-pyridinedicarboxylic acid (dipicolinic acid, or DPA), a molecule that is present at high concentrations in spores of Clostridium and Bacillus, the latter of which includes the threat organism Bacillus anthracis, or anthrax. Dipicolinic acid may be useful as a first-step discriminator of the biological warfare agent B. anthracis. The results of experiments with B. anthracis Sterne strain and Bacillus thuringiensis spores lead to a conceptual model for the chemical …

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Learning Russian Case Endings Through Model Sentences, Sara Lyn Jensen Jul 2007

Learning Russian Case Endings Through Model Sentences, Sara Lyn Jensen

Theses and Dissertations

The current study examines aspects of the Russian language that are particularly challenging for English-speaking students. It focuses on the complexity of Russian's grammatical morphology, specifically Russian case endings. In this study, methods and theories from the field of Second Language Acquisition (SLA) are reviewed to support a study aide designed by the author to help students with the acquisition of Russian case endings. The proposed study aide consists of 24 sentences composed of high-frequency Russian words. The 24 sentences contain all regular (approximately 75) Russian case endings. The purpose of the model sentences is to teach case forms using …

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The Origins, Evolution, And Phylogeny Of The Praying Mantises (Dictyoptera: Mantodea), Gavin John Svenson Jul 2007

The Origins, Evolution, And Phylogeny Of The Praying Mantises (Dictyoptera: Mantodea), Gavin John Svenson

Theses and Dissertations

The relatively small insect order Mantodea (praying mantises) is comprised of approximately 2,366 described species distributed in 436 genera. Members of the group occupy diverse habitats and are distributed across the globe, though their greatest numbers and diversity are concentrated primarily in the tropics. Though continental endemism is common, many groups have a broad global distribution. An immense diversity of morphology is exhibited across the order with adult mantises ranging in size from 2cm to ~25cm, and appearing like a dead leaf, a piece of quartz rock, or a blade of grass. The diversification and specialization of mantises in ecologically …

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Protein Coevolution And Coadaptation In The Vertebrate Bc1 Complex, Kimberly Kay Baer Jul 2007

Protein Coevolution And Coadaptation In The Vertebrate Bc1 Complex, Kimberly Kay Baer

Theses and Dissertations

The cytochrome bc1 complex of the mitochondrial electron transport chain accomplishes the enzymatic reaction known as the modified Q-cycle. In the Q-cycle the bc1 complex transports protons from the matrix to the intermembrane space of the mitochondria, creating the proton gradient used to make ATP. The energy to move these protons is obtained by shuttling electrons from the coenzyme ubiquinol (QH2) to coenzyme ubiquinone (Q) and the mobile cytochrome c. This well studied complex is ideal for examining molecular adaptation because it consists of ten different subunits, it functions as a dimer, and it includes at least five different active …

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Characterization Of A Novel Nuclear Variant Of Bmp2 And Coordinate Regulation Of Col11a2 And Col27a1 By The Transcription Factor Lc-Maf, Jaime Lynn Mayo Jul 2007

Characterization Of A Novel Nuclear Variant Of Bmp2 And Coordinate Regulation Of Col11a2 And Col27a1 By The Transcription Factor Lc-Maf, Jaime Lynn Mayo

Theses and Dissertations

ABSTRACT I CHARACTERIZATION OF A NOVEL NUCLEAR VARIANT OF BMP2

Bone morphogenetic protein 2 (Bmp2) is a signaling protein that was first detected by its ability to induce cartilage and bone formation. It has since been implicated in broad variety of developmental, patterning, and disease processes. To date, Bmp2 has only been known to function as an extracellular signaling molecule. However, we have obtained clear evidence for a nuclear form of Bmp2. This nuclear variant, nBmp2, contains a bipartite NLS that overlaps the site of proteolytic cleavage. The NLS remains intact and functional when translation of Bmp2 initiates from a …

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Regulation Of Adrenal Steroidogenesis By Interleukin-6, Stephen A. Mcilmoil Jul 2007

Regulation Of Adrenal Steroidogenesis By Interleukin-6, Stephen A. Mcilmoil

Theses and Dissertations

Cortisol and dehydroepiandrosterone (DHEA) are steroids produced by the zona fasciculata (ZF) and reticularis (ZR), respectively, of the adrenal cortex. Both steroids are upregulated in response to adrenocorticotropic hormone (ACTH). Cortisol is a glucorticoid that is important in the regulation of inflammation and metabolism. DHEA is an adrenal androgen important in fetal growth and puberty but tends to decrease gradually after puberty in both men and women. DHEA has various effects on metabolism and immune function including inhibiting the effects of cortisol on some tissues. During the acute phase of stress, cortisol and DHEA rise due to an increase in …

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Bioassessment And The Partitioning Of Community Composition And Diversity Across Spatial Scales In Wetlands Of The Bonneville Basin, Mary Jane Keleher Jul 2007

Bioassessment And The Partitioning Of Community Composition And Diversity Across Spatial Scales In Wetlands Of The Bonneville Basin, Mary Jane Keleher

Theses and Dissertations

The Bonneville Basin encompasses an area that was covered by ancient Lake Bonneville and which today lies within the Great Basin province. The Bonneville Basin is distinguished geologically by its characteristic parallel north-south mountain ranges that are separated by broad, alluviated desert basins and valleys. Benches and other shoreline features of ancient Lake Bonneville prominently mark the steep, gravelly slopes of these ranges. Numerous artesian desert springs are present at the base of the mountains and in the valley floors that form various sizes of both isolated wetlands and wetland complexes. Many these wetlands are some of the most unique …

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Development And Characterization Of Microsatellite Markers For The Grain Amaranths (Amaranthus Spp. L.), Melanie Ann Mallory Jul 2007

Development And Characterization Of Microsatellite Markers For The Grain Amaranths (Amaranthus Spp. L.), Melanie Ann Mallory

Theses and Dissertations

The grain amaranths (Amaranthus hypochondriacus L., A. cruentus L., and A. caudatus L.) are important pseudocereals native to the Americas that have received increased attention for their nutritional content, specifically their balance of amino acids. The objective of this project was to produce and characterize a set of highly informative, reproducible microsatellite markers for the grain amaranths. A total of 1457 clones were sequenced from three genomic libraries enriched for the microsatellite motifs AAC, AAT and AC. Of these, 353 (24%) contained unique microsatellites. An additional 29 microsatellite loci were identified among 728 BAC-end sequences of a newly developed amaranth …

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The Prolamins Of Pearl Millet, Christian B. Ricks Jul 2007

The Prolamins Of Pearl Millet, Christian B. Ricks

Theses and Dissertations

Although work on the prolamins of pearl millet (Pennisetum glaucum) has revealed partial amino acid sequences for several alcohol-soluble storage proteins (Marcellino et al. 2002) the genes encoding them have not yet been isolated. We constructed a cDNA library from developing P. glaucum seed tissue and screened it using maize zein gene probes to isolate several α-prolamin-like gene sequences. The proteins encoded by these genes generally fall into two size classes: 20.6kD and 27.1kD, which we call the 21kD and 27kD pennisetins. Both proteins are similar in composition and sequence to α-prolamins from maize, sorghum and Coix. Protein bodies that …

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Regulation Of Lkb1-Strad-Mo25 Complex Expression And Activation Of Ampk In Skeletal Muscle By Thyroid Hormone, Devon Jack Branvold Jul 2007

Regulation Of Lkb1-Strad-Mo25 Complex Expression And Activation Of Ampk In Skeletal Muscle By Thyroid Hormone, Devon Jack Branvold

Theses and Dissertations

AMP-activated protein kinase (AMPK), a heterotrimeric protein which serves as a metabolic master switch in skeletal muscle, is a research target for the pharmaceutical treatment and prevention of type 2 diabetes. The expression of all of the isoforms of the subunits of AMPK and AMPK activity are increased in skeletal muscle tissue of hyperthyroid rats. Activity of AMPK is regulated by an upstream kinase (AMPKK). The LKB1-STRAD-MO25 complex is a major AMPKK in skeletal muscle. This experiment was designed to determine whether the increase in AMPK activity is accompanied by a thyroid hormone-induced increase in the expression of the LKB1-STRAD-MO25 …

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Synthesis And Antiviral Evaluation Of Some 3'-Carboxymethyl-3'-Deoxyadenosine Derivatives, Houguang Shi Jul 2007

Synthesis And Antiviral Evaluation Of Some 3'-Carboxymethyl-3'-Deoxyadenosine Derivatives, Houguang Shi

Theses and Dissertations

3'-Carboxymethyl-3'-deoxyadenosine derivatives were prepared from 2'-O-TBDMS-3'-deoxy-3'-[(ethoxycarbonyl)methyl]adenosine (1) via simple and efficient procedures. Conversion of 1 to 5'-azido-2'-O-TBDMS-3', 5'-dideoxy -3'-[(ethoxycarbonyl) methyl] adenosine (4) was accomplished via a novel one-pot method employing 5'-activation (TosCl) followed by efficient nucleophilic displacement with tetramethylguanidinium azide. Compound 4 was converted to a 5'-[(N-methylcarbamoyl)amino] derivative (5) via one-pot reduction/acylation employing H2/Pd-C followed by treatment with p-nitrophenyl N-methylcarbamate. The latter step of this two-step process required an efficient source of p-nitrophenyl N-methylcarbamate, thus a highly efficient new method for preparing p-nitrophenyl N-alkylcarbamate was developed. N6-phenylcarbamoyl groups were introduced by treatment with phenylisocyanate, and an efficient new method for …

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Ultrasonically-Assisted Drug Delivery In Rats Reduces Tumor Growth, William G. Pitt, Beverly L. Roeder, G. Bruce Schaalje, Bryant J. Staples Jul 2007

Ultrasonically-Assisted Drug Delivery In Rats Reduces Tumor Growth, William G. Pitt, Beverly L. Roeder, G. Bruce Schaalje, Bryant J. Staples

Faculty Publications

Previously we have shown that nanosized drug carriers called Plurogels™ sequestered Doxorubicin (Dox) and partially released this drug with application of ultrasound (US) (Fig. 1)1. The application to chemotherapy was successfully demonstrated in a rat tumor model2. However previous studies did not examine the distribution of Dox in the insonated and control tissue. This recent work investigated the effect of two US frequencies and examined the Dox distribution in the insonated and control tumors to determine if US was depositing more Dox at the insonated site.

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Development Of Deployable Wings For Small Unmanned Aerial Vehicles Using Compliant Mechanisms, Steven D. Landon Jul 2007

Development Of Deployable Wings For Small Unmanned Aerial Vehicles Using Compliant Mechanisms, Steven D. Landon

Theses and Dissertations

Unmanned Air Vehicles (UAVs) have recently gained attention due to their increased ability to perform sophisticated missions with less cost and/or risk than their manned counterparts. This thesis develops approaches to the use of compliant mechanisms in the design of deployable wings for small UAVs. Although deployable wings with rigid-link mechanisms have been used in the past to maintain flight endurance while minimizing required storage volume, compliant mechanisms offer many advantages in manufacturability and potential space savings due to function sharing of components. A number of compliant, deployable wing concepts are generated and a classification system for them is formed. …

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