Digital Commons Network^™

Psychological Pathways Linking Social Support To Health Outcomes: A Visit With The “Ghosts” Of Research Past, Present, And Future, Wendy C. Birmingham, Bert N. Uchino, Kimberly Bowen, Mckenzie Carlisle

Faculty Publications

Contemporary models postulate the importance of psychological mechanisms linking perceived and received social support to physical health outcomes. In this review, we examine studies that directly tested the potential psychological mechanisms responsible for links between social support and health-relevant physiological processes (1980s to 2010). Inconsistent with existing theoretical models, no evidence was found that psychological mechanisms such as depression, perceived stress, and other affective processes are directly responsible for links between support and health. We discuss the importance of considering statistical/design issues, emerging conceptual perspectives, and limitations of our existing models for future research aimed at elucidating the psychological mechanisms …

Fluidic Assembly At The Microscale: Progress And Prospects, Nathan B. Crane, Onursal Onen, Jose Carballo, Qi Ni, Rasim Guldiken

Faculty Publications

Assembly permits the integration of different materials and manufacturing processes to increase system functionality. It is an essential step in the fabrication of useful systems across size scales from buildings to molecules. However, at the microscale, traditional “grasp and release” assembly methods and chemically inspired self-assembly processes are less effective due to many scaling effects. Many methods have been developed for improving microscale assembly. Often these methods include fluidic forces or the use a fluidic medium in order to enhance their performance. This paper reviews basic assembly theory and modeling methods. Three basic assembly strategies (tool-directed, process-directed, and part-directed) are …

Association Between C-Reactive Protein And Cognitive Deficits In Elderly Men And Women: A Meta-Analysis, Bruce L. Brown, Dawson W. Hedges, Thomas J. Farrer

Faculty Publications

Abstract

Background: Certain risk factors for cognitive decline appear modifiable. A potentially modifiable marker of inflammation, C-reactive protein may be associated with cognitive deficits, although not all studies have found a relationship between C-reactive protein and cognitive ability. Further, few research papers have examined whether gender may affect any association between C-reactive protein and cognitive deficit.

Methods: To better understand the association between C-reactive protein, cognitive deficit, and gender in elderly people, we meta-analyzed cross-sectional studies that reported cognitive ability assessed by the Mini-Mental State Examination or an equivalent measure, C-reactive protein concentrations, and gender.

Results: While we identified no …

Examining A Brief Suicide Screening Tool In Older Adults Engaging In Risky Alcohol Use, Scott R. Braithwaite, Jessica D. Ribeiro, Jon J. Peaff, Thomas E. Joiner

Faculty Publications

Alcohol misuse increases risk of suicidal behavior in older adults. TheDepressive Symptom Inventory-Suicidality Subscale (DSI-SS; Metalsky & Joiner,1997) and its relation to suicide attempt history was examined to see if it differedfor older adults as a function of their alcohol use. Structural equation modelingwas used in a sample (N= 1,061) of older adult outpatients to examine the scale’smeasurement invariance and population heterogeneity and its relation to suicideattempt history. Analyses supported the equivalence of the DSI-SS in risky andnonrisky drinkers. The DSI-SS significantly predicted past suicide attempts. Find-ings support the viability of the DSI-SS as suicide screening tool for older adults.

Subliminal Activation Of Social Ties Moderates Cardiovascular Reactivity During Acute Stress, Wendy C. Birmingham, Mckenzie Carlisle, Bert N. Uchino, David M. Sanbonmatsu, Timothy W. Smith, Matthew R. Cribbet, Kathleen C. Light, Allison A. Vaughn

Faculty Publications

Objective—The quality of one’s personal relationships has been reliably linked to important physical health outcomes, perhaps through the mechanism of physiological stress responses. Most studies of this mechanism have focused on whether more conscious interpersonal transactions influence cardiovascular reactivity. However, whether such relationships can be automatically activated in memory to influence physiological processes has not been determined. The primary aims of this study were to examine if subliminal activation of relationships could influence healthrelevant physiological processes, and to examine this question in the context of a more general relationship model that incorporates both positive and negative dimensions. Method—We randomly assigned …

Evaluative Threat And Ambulatory Blood Pressure: Cardiovascular Effects Of Social Stress In Daily Experience, Wendy C. Birmingham, Timothy W. Smith, Bert N. Uchino

Faculty Publications

Objective—Physiological effects of social evaluation are central in models of psychosocial influences on physical health. Experimental manipulations of evaluative threat evoke substantial cardiovascular and neuroendocrine responses in laboratory studies, but only preliminary evidence is available regarding naturally-occurring evaluative threats in daily life. In such non-experimental ambulatory studies, it is essential to distinguish effects of evaluative threat from related constructs known to alter stress, such as ability perceptions and concerns about appearance. Methods—94 married, working couples (mean age 29.2 years) completed a one-day (8am to 10pm) ambulatory blood pressure (ABP) protocol with random interval-contingent measurements using a Suntech monitor and Palm …

Social Relationships And Mortality, Julianne Holt-Lunstad, Timothy B. Smith

Faculty Publications

Social relationships benefit not only mental health but also physical health. This review addresses the following questions: (1) What is the overall magnitude of the effect of social relationships on risk for premature death? (2) How generalized is the effect and are there factors known to influence this association? (3) What are the likely pathways by which social relationships influence longevity? The article concludes by discussing the implications of these findings for potential interventions aimed at reducing risk for mortality.

Design And Synthesis Of Cationic Steroid Antimicrobial Compounds, Synthesis Of Glycolipids Recognized By Natural Killer T Cells And Development Of Tlr-1, Tlr-6 Heterodimer Binders And Studies Of Their Immunology Activities, Yanshu Feng

Theses and Dissertations

Cationic steroid antimicrobial agents (CSAs) are a family of bile acid derivatives. These compounds are amphiphilic and mimic endogenous antimicrobial peptides. The antimicrobial activities of CSA-13 have been investigated and due to portent bactericidal activities and low toxicity, a large amount of CSA-13 is demanded for clinic trails and other antimicrobial applications. During our studies, we optimized the synthetic route of CSA-13, so that it can be prepared at the kilogram, even in tons scale. We investigated three routes and one of them is suitable for industry, because only recrystallization is needed in the synthesis. Natural killer T cells (NKT …

Characterization Of The Role Nuclear Bmp2 (Nbmp2) Plays In Regulating Gene Expression, Fialka Grigorova

Theses and Dissertations

The nBmp2 protein was first identified in a DNA affinity chromatography/mass spectrometry screen designed to detect proteins that interact with a cartilage-specific enhancer element (called D/E) from the type XI collagen gene Col11a2. The transcription factor SOX9, a protein from the Sox (SRY-related HMG box) family, binds to and activates gene expression from this enhancer. nBmp2 has no transcriptional activity of its own on this enhancer, but when co-transfected with SOX9 it increases SOX9's activation of D/E nearly 2-fold. SOX9 also activates cartilage-specific enhancer elements from the Col2a1, Col27a1, and Col9a1 genes. The purpose of this project …

Influence Of Weak Interactions On Supramolecular Binding: Characterization Of Cucurbituril Complexes With Alkylmonoammonium Ions Using Fourier Transform Ion Cyclotron Resonance Mass Spectrometry, Ruijan Shi

Theses and Dissertations

This thesis focuses on using mass spectrometry-based techniques for characterizing the structure and behavior of cucurbituril complexes in the gas phase. Both solvent and counter ion effects can be completely eliminated in the gas phase and the intrinsic interactions in the system are directly shown in the experimental results. Chapter 1 introduces the structures, properties and host-guest chemistry of cucurbituril, and FTICR mass spectrometry including instrumentation, performance and working principles. Two mass spectrometry-based methods for supramolecular characterization, sustained off-resonance irradiation collision induced dissociation (SORI CID) and ion molecule equilibrium measurements, are also discussed in this chapter. Chapter 2 characterizes the …

A Floristic Survey Of The Lichens Of The Spring Mountains, Nevada, Usa, Monica W. Proulx

Theses and Dissertations

This thesis is the culmination of a graduate research project involving a floristic survey of the lichens of the Spring Mountain National Recreation Area (SMNRA), Humboldt-Toiyabe National Forest, Nevada. The project was based on extensive collections made between 1997 and 2007 as part of an air pollution biomonitoring program and a baseline established by Larry St. Clair (BYU). The Spring Mountains are a sky island mountain range in the Mojave Desert located less than an hour northwest of Las Vegas. A floristic survey of the lichen communities in the Spring Mountains represents a major addition to our understanding of the …

The Female Experience: Study Abroad Students In Egypt, Heather Raquael Walsh

Theses and Dissertations

This qualitative study explores the experiences of female students on study abroad programs, with the aim of answering the following questions: do they face unique challenges as female students (including harassment or assault), how do they avoid or cope with any negative experiences, and can we as language departments better prepare our students to have the best experiences possible? The participants for the study were primarily 12 of 50 students involved in the Brigham Young University Study Abroad to Cairo, Egypt during Spring and Summer terms 2010. Data include participant observation, student journals, and ethnographic interviews conducted during the last …

Mechanism Of G Protein Beta-Gamma Assembly Mediated By Phosducin-Like Protein 1, Chun Wan Jeffrey Lai

Theses and Dissertations

G-protein coupled receptor signaling (GPCR) is essential for regulating a large variety of hormonal, sensory and neuronal processes in eukaryotic cells. Because the regulation of these physiological responses is critical, GPCR signaling pathways are carefully controlled at different levels within the cascade. Phosducin-like protein 1 (PhLP1) can bind the G protein βγ dimer and participate in GPCR signaling. Recent evidence has supported the concept that PhLP1 can serve as a co-chaperone of the eukaryotic cytosolic chaperonin complex CCT/TRiC to mediate G βγ assembly. Although a general mechanism of PhLP1-mediated G βγ assembly has been postulated, many of the details about …

Impact Of Indigenous Language On Achievement And Emotional Conditions: A Case Study Of East European Students In Utah, Natalya Georgiyeva

Theses and Dissertations

The importance of using an indigenous language as a medium of school instruction has been discussed in world education for a long time. This study focuses on the influence of the presence of a native language in the learning process of the students and the impact on their academic achievement, emotional conditions, and post-school lives. A qualitative method of research was used in the study, comprising 12 interviews among Ukrainian/Russian adopted and nonadopted students who attended Utah schools. Information obtained through interviews presented language levels of students (both native and English), academic achievement, and emotional conditions of students during the …

A General Model For Continuous Noninvasive Pulmonary Artery Pressure Estimation, Robert Anthony Smith

Theses and Dissertations

Elevated pulmonary artery pressure (PAP) is a significant healthcare risk. Continuous monitoring for patients with elevated PAP is crucial for effective treatment, yet the most accurate method is invasive and expensive, and cannot be performed repeatedly. Noninvasive methods exist but are inaccurate, expensive, and cannot be used for continuous monitoring. We present a machine learning model based on heart sounds that estimates pulmonary artery pressure with enough accuracy to exclude an invasive diagnostic operation, allowing for consistent monitoring of heart condition in suspect patients without the cost and risk of invasive monitoring. We conduct a greedy search through 38 possible …

Chemical Templating By Afm Tip-Directed Nano-Electrochemical Patterning, Kyle A. Nelson

Theses and Dissertations

This work has examines the creation and use of chemical templates for nanocircuit and other nanodevice fabrication. Chemical templating can be useful in attachment, orientation and wiring of molecularly templated circuits. DNA origami provides a suitable method for creating molecularly templated circuits as DNA can be folded into complex shapes and functionalized with active circuit elements, such as semiconducting nanomaterials. Surface attachment of DNA origami structures can be accomplished by hybridization of dangling single-stranded DNA (ssDNA) on the origami structures with complementary surface-bound strands. Chemical templating provides a pathway for placing the patterned surface-bound attachment points needed for surface alignment …

C-Met Initiates Epithelial Scattering Through Transient Calcium Influxes And Nfat-Dependent Gene Transcription, Peter R. Langford

Theses and Dissertations

Hepatocyte growth factor (HGF) signaling drives epithelial cells to scatter by breaking cell-cell adhesions and migrating as solitary cells, a process that parallels epithelial-mesenchymal transition. HGF binds and activates the c-Met receptor tyrosine kinase, but downstream signaling required for scattering remains poorly defined. This study addresses this shortcoming in a number of ways.A high-throughput in vitro drug screen was employed to identify proteins necessary in this HGF-induced signaling. Cells were tested for reactivity to HGF stimulation in a Boyden chamber assay. This tactic yielded several small molecules that block HGF-induced scattering, including a calcium channel blocker. Patch clamping was used …

The Infant Orienting Response As It Relates To Mother-Infant Co-Regulation And Attachment, Sarah Ann Ahlander Stone

Theses and Dissertations

This study examined the relationship between 6-month old infants' orienting response to maternal arm-restraint (as measured by bradycardia), the quality of mother-infant communication at 6 and 9 months (as measured by the Relational Coding System) and attachment at 12 months (as measured by the Strange Situation Procedure). As positive mother-infant communication increases, the chances the infant will experience bradycardia increases. As negative mother-infant communication increases, the chances that the infant will experience bradycardia decreases. For mothers and infants who have more positive communication patterns, orienting response to the maternal arm-restraint suggests that maternal disruption of infant activity was a novel …

Seasonal Habitat Selection By Greater Sage Grouse In Strawberry Valley Utah, Riley D. Peck

Theses and Dissertations

This study examined winter habitat use and nesting ecology of greater sage grouse (Centrocercus urophasianus) in Strawberry Valley (SV), Utah located in the north-central part of the state. We monitored sage grouse with the aid of radio telemetry throughout the year, but specifically used information from the winter and nesting periods for this study. Our study provided evidence that sage grouse show fidelity to nesting areas in subsequent years regardless of nest success. We found only 57% of our nests located within the 3 km distance from an active lek typically used to delineate critical nesting habitat. We …

The Relationship Of Adult Attachment Dimensions And Neuroticism To Relationship Self-Regulation, Garret Tyler Roundy

Theses and Dissertations

Self-regulation in the context of a relationship, described as relationship "work," is a powerful predictor of relationship satisfaction. Identifying individual characteristics that predict the practice of relationship self-regulation (RSR) can inform clinical and couple relationship education interventions. Anxious and avoidant attachment have been linked to shortcomings in self-regulation in various contexts, and were hypothesized to be negatively associated to individual practice of RSR; neuroticism, a personality trait characterized by negative emotionality, was also hypothesized to be negatively related to RSR. Neuroticism was also tested as a moderator of the relationship between attachment and RSR. Data from first-married men (589) and …

Stable Isotope Diet Reconstruction Of Feral Horses (Equus Caballas) On The Sheldon National Wildlife Refuge, Nevada, Usa, Megan Kathleen Nordquist

Theses and Dissertations

Feral horse management has become a subject of significant controversy in the United States. This is because of differing opinions and minimal recent empirical data on feral horses. In recent years, numbers of feral horses have increased due to governmental horse removal restrictions (specifically the Wild Horse and Burro act of 1971). With increasing numbers of feral horses on rangelands, land managers are challenged with identifying the appropriate course of action for satisfying groups with differing opinions. The purpose of this study is to characterize diet consumption through the use of stable isotope dietary analysis (δ15N and δ13C). We did …

Educating Mexico In Emilio Fernández's Río Escondido And Rosario Castellanos's Balún Canán, David Scott Dalton

Theses and Dissertations

Following the bloody Revolution of 1910-1917, Mexican leaders took a great interest in rebuilding their devastated, war-torn country. In an attempt to further national unity, the post-Revolutionary regime sought to construct a unified, national identity. Many officials, such as José Vasconcelos, Mexico's first Secretario de Educación, viewed education as one of the keys to redeeming the nation. These government officials, empowered by their ideals and their sense of civic duty, worked to extend educational benefits to even the most overlooked segments of Mexican society. This thesis will examine two fictional texts that consider these efforts to transform and unify …

Influence Of Supraglottal Geometry And Modeling Choices On The Flow-Induced Vibration Of A Computational Vocal Fold Model, Timothy E. Shurtz

Theses and Dissertations

Computational models of the flow-induced vibrations of the vocal folds are powerful tools that can be used in conjunction with physical experiments to better understand voice production. This thesis research has been performed to contribute to the understanding of vocal fold dynamics as well as several aspects of computational modeling of the vocal folds. In particular, the effects of supraglottal geometry have been analyzed using a computational model of the vocal folds and laryngeal airway. In addition, three important computational modeling parameters (contact line location, Poisson's ratio, and symmetry assumptions) have been systematically varied to determine their influence on model …

Surface Modification Of Liposomes Containing Nanoemulsions, Jonathan Michael Hartley

Theses and Dissertations

Many attempts have been made to make cancer therapy more selective and less detrimental to the health of the patients. Nanoparticles have emerged as a way to solve some of the problems of traditional chemotherapy. Nanoparticles can provide protection for the therapeutic from degradation or clearance, as well as protection to healthy tissue from the damaging effects of chemotherapy drugs. Researchers are pursuing different strategies but all have the same goals of improving the outcomes of cancer patients. The field of controlled release of drugs has increased significantly in hopes of better treating diseases like cancer. Improved control of drug …

Factors Related To Parental Approval Of Adult Childrens' Engagement Relationships, Marietta Malnar

Theses and Dissertations

This study examined possible factors that may influence parental approval for their adult child's engaged relationship. A total of 4,175 individuals completed the RELATE inventory. Among the items in the questionnaire were measures of parental approval, parents' marital quality, autonomy from family-of-origin, and relationship quality. Individuals also reported age, education, length of relationship, parents' marital status, and parents' socioeconomic status. Results from the linear regression analysis indicate that age, parental marital quality, autonomy from family-of-origin, and couple relationship quality all influence parental approval. What is interesting about these findings is the difference in the predictive power of males versus females. …

The Effect Of Sexblindness And Sexawareness On Workplace Related Gender Bias, Katie Nichol

Theses and Dissertations

The present study was an adaptation of Richeson and Nussbaum's (2004) study of racism to gender bias. Two different gender ideologies were theoretically analyzed, then the influence of these ideologies on implicit and explicit forms of gender bias was examined. Psychology undergraduates were presented with a prompt promoting either a sexblind or sexaware approach to reducing gender bias. Participants then completed a measure of implicit (IAT Gender/Career) and explicit (MAWWWS) bias. Results suggested that, relative to the sexaware perspective, the sexblind perspective generated less implicit gender bias. There was no difference between ideological groups on the explicit measure. The findings …

Effect Of Experimentally-Induced Anterior Knee Pain On Postural Control, Emily Elizabeth Falk

Theses and Dissertations

Context: Knee pain is experienced by many people. Because of this, authors have started researching the effects of pain on lower extremity mechanics and also on static and dynamic postural control. However, the effects of pain are difficult to study due to associated confounding variables. Objective: We asked: (1) Will experimentally-induced anterior knee pain alter perceived pain using the visual analogue scale? ; (2) will perceived pain affect postural control as measured by center-of-pressure during static and dynamic movement? Design: Crossover. Setting: Biomechanics laboratory. Participants: Fifteen healthy subjects. Intervention: Each subject participated in single leg quiet stance, landing, and walking …

Using Expert Knowledge To Satisfy Data Needs: Mapping Invasive Plant Distributions In The Western United States, Bethany A. Bradley, David C. Marvin

Western North American Naturalist

Lack of knowledge about the distributions of plant and animal species can severely hamper management efforts. For invasive plants, distribution and abundance data can inform early detection and rapid response (EDRR) programs aimed at treating initial infestations. These data can be used to create invasion risk models at landscape and regional scales. Further, regional maps of invasive plant abundance are useful for communicating the scope of the invasive species problem to the public and policymakers. Here, we present a set of regional distribution maps for 10 problematic invasive plants in the western United States, created from the expert knowledge of …

Distribution And Diet Of Largemouth Bass (Micropterus Salmoides) In The Lower Boise River, Idaho, Camrin D. Braun, Christoph A. Walser

Western North American Naturalist

Where introduced, largemouth bass (Micropterus salmoides) are known to have negative effects on aquatic ecosystems. In this study, we used historical museum collection records (1942–2006) and contemporary (2009) collections to assess changes in the distribution of largemouth bass in the lower Boise River (southwestern Idaho). We also examined the stomach contents of largemouth bass collected during the contemporary survey to determine diet. Seventy-four largemouth bass (45–137 mm TL) were represented in 13 historical collections from 5 lower Boise River locations. During autumn 2009, we sampled 8 sites in the lower Boise River for largemouth bass. Sixty-one largemouth bass …

Sheep Bedding In The Centennial Mountains Of Montana And Idaho: Effects On Vegetation, Steven S. Seefeldt, April B. Leytem

Western North American Naturalist

In summer, bands of sheep are grazed in western North American mountains. At night the sheep are concentrated into bedding areas. In the study area, each bedding area is only utilized by sheep for one night a year for 2 out of 3 years. Vegetation in the bedding areas was compared to vegetation outside these areas. Both perennial forb cover and total perennial cover were greater outside (48% and 61%, respectively) than inside (29% and 36%, respectively) the bedding areas. Annual forb cover one year after sheep grazing was greater inside (17%) bedding areas than outside (5%). Immediately after sheep …