Digital Commons Network^™

Chemogenetic Stimulation Of Electrically Coupled Midbrain Gaba Neurons In Alcohol Reward And Dependence, Stephanie Suzette Pistorius

Theses and Dissertations

The prevailing view is that enhancement of dopamine (DA) transmission in the mesolimbic system leads to the rewarding properties of alcohol. The mesolimbic DA system, which plays an important role in regulating reward and addiction, consists of DA neurons in the midbrain ventral tegmental area (VTA) that innervate the nucleus accumbens (NAc). It is believed that VTA DA neurons are inhibited by local gamma-aminobutyric acid (GABA) interneurons that express connexin-36 (Cx36) gap junctions (GJs). We have previously demonstrated that blocking Cx36 GJs suppresses electrical coupling between VTA GABA neurons and reduces ethanol intoxication and consumption suggesting that electrical coupling between …

Evaluation Of A Social And Emotional Learning Curriculum Integrated Into A Middle School Health Classroom, Stephanie Susan Skiba

Theses and Dissertations

Although approximately one-fourth of adolescents have a mental health disorder only half of them receive treatment. The goal of this study was to determine if Strong Kids, a social and emotional learning curriculum, implemented over a 4-week period could help decrease internalizing symptoms and increase resilience in middle school students, something not previously investigated. This study also measured social and emotional knowledge as measured by the Strong Kids questionnaire. Additionally, treatment fidelity and social validity were measured. The study used a non-equivalent, control group design. The sample consisted of 148 students: 70 in the treatment group and 78 in …

Insulin And Ketones: Their Roles In Brain Mitochondrial Function, Sheryl Teresa Carr

Theses and Dissertations

The prevalence of both Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) is increasing worldwide, and the trends are unfortunately expected to continue. AD has recently been tied with mitochondrial dysfunction and insulin resistance, creating a mechanistic tie between AD and T2DM. Unfortunately, insulin resistance is often increased with aging and therefore, all individuals are at risk of brain mitochondrial dysfunction. Without proper mitochondrial function, the brain will degenerate, causing impaired cognitive function and reduced quality of life. The purpose of this study is two-fold: first, to understand the role of ceramides in insulin-induced brain mitochondrial dysfunction, and; second, …

Natural Disaster Films: A Social Learning And Perceived Realism Perspective, Melissa Seipel

Theses and Dissertations

This study investigates the relationship between social learning and perceived realism in the context of an entertainment media text, the 2015 movie San Andreas. As a fictional natural disaster movie, this film depicts several safety and survival techniques that could potentially be observed and adopted by audience members should they face a similar situation (i.e. major earthquake). While the majority of these techniques align with professionally recommended behaviors, a few are misleading. This study investigates the perceptions, attitudes, beliefs, and behavioral intentions different groups of audience members hold concerning the behaviors they observed in the film. Participants were grouped by …

Desorption Electrospray Ionization (Desi) Mass Spectrometric Imaging Of Spatially Regulated In Vivo Metabolic Rates, Charlotte Reininger Lewis

Theses and Dissertations

Desorption electrospray ionization (DESI) is an ambient ionization technique used for mass spectrometric imaging of biological samples. When coupled with isotopic ratio measurements of deuterium-labeled tissues, DESI provides a means of measuring metabolic rates on a spatially resolved basis. In vivo metabolic rates are desired to better understand diseases such as Alzheimer's, Parkinson's, Huntington's, and various forms of cancer that negatively impact metabolic rates within different organs of the human body. Although DESI has been used to image lipids and metabolites of a variety of tissues and other imaging techniques, such as NIMS, have been used to study kinetic turnover …

Network Reconstruction And Vulnerability Analysis Of Financial Networks, Nathan Scott Woodbury

Theses and Dissertations

Passive network reconstruction is the process of learning a structured (networked) representation of a dynamic system through the use of known information about the structure of the system as well as data collected by observing the inputs into a system along with the resultant outputs. This work demonstrates an improvement on an existing network reconstruction algorithm so that the algorithm is capable of consistently and perfectly reconstructing a network when system inputs and outputs are measured without error. This work then extends the improved network reconstruction algorithm so that it functions even in the presence of noise as well as …

“The Scourge Of The Bourgeois Feminist”: Alexandra Kollontai’S Strategic Repudiation And Espousing Of Female Essentialism In The Social Basis Of The Woman Question, Hannah Pugh

AWE (A Woman’s Experience)

In The Social Basis of the Woman Question, Bolshevik feminist Alexandra Kollontai responds to bourgeois feminists’ essentialist calls for female solidarity to resolve the “woman’s question”—the question of women’s status in society— by presenting the woman question as a struggle defined not by gender but by the intersection of class and gender. Kollontai appropriates and extends their essentialist rhetoric, engaging in the classed and gendered essentialism of the particular socioeconomic position of the female worker. I argue that, by placing the essentialized woman worker at the heart of the woman question, Kollontai suggests that the woman question is an economic …

Designing The Technological World Through Biomimicry, Emily Yoshikawa, Greg J. Strimel, Scott R. Bartholomew

Faculty Publications

Scientific discoveries are a driver for advancing our technological world (ITEA/ITEEA; 2000/2002/2007). As more knowledge is acquired through scientific inquiry, people can better design and develop technological inventions and innovations (Knowles, Kelley, & Hurd, 2016). In turn, these novel technologies can aid in making new scientific discoveries, thus driving an ongoing cycle of technological advancement. However, in the process of designing and advancing our technological world, people can turn to the study of life and its phenomena to inspire and inform their designs. Nature is functional as well as beautiful. As we study the phenomena or functions of living organisms …

"I Think, Therefore I Do": Cognitions Related To Flourishing In Emerging Adulthood, Larry J. Nelson, Nathan A. Jorgensen, Adam A. Rogers

Faculty Publications

The focus of this volume is to bring greater attention to the ways in which many young people flourish during the third decade of life. In doing so, the majority of the chapters have focused on the things that emerging adults do that reflect positive development (e.g., volunteerism, service, political activism, education, preparation for careers). It may be, however, that the very way in which young cognitively approach the third decade might influence whether they flourish or flounder. Also, it may be that how they view adulthood (i.e., the fourth decade of life and beyond) might have bearing on what …

Positive Relationships As An Indicator Of Flourishing During Emerging Adulthood, Laura M. Padilla-Walker, Madison K. Memmott-Elison, Larry J. Nelson

Faculty Publications

In any discussion about flourishing in emerging adulthood, it would be easy to simply think about the positive things that young people do (e.g., pursue education, volunteer, serve, engage in political activism). However, few emerging adults walk the path toward adulthood alone. They embark on and make their way through the third decade of life within a myriad of complex relationships with family, friends, and romantic partners. However, the changing nature of these relationships is arguably more complex than at any other point in their lives to date. Graduation (for most) from high school brings the dissolution of many peer …

Beyond The Bucket List: Identity-Centered Religious Calling, Being, And Action Among Parents, David C. Dollahite, Loren D. Marks, Taleah M. Kear, Brittany M. Lewis, Megan L. Stokes

Faculty Publications

From a positive family psychology perspective, this study explores identity-centered religious calling, being, and action among parents of youth, that is, what religious parents believe they are called to be and to do in relation to their adolescent children. Twenty-nine Christian, Jewish, and Muslim families of youth (N = 58) were asked what they considered most important for them "to be" and "to do" as parents of faith. Qualitative analyses were conducted to determine major themes of responses. Parents indicated they believed they were called to be (A1) an example, (A2) authentic, and (A3) consistent; called to provide their …

Activity Of Distinct Growth Factor Receptor Network Components In Breast Tumors Uncovers Two Biologically Relevant Subtypes, Mumtahena Rahman, Shelley M. Macneil, David F. Jenkins, Gajendra Shrestha, Sydney R. Wyatt, Jasmine A. Mcquerry, Stephen R. Piccolo, Laura M. Heiser, Joe W. Gray, W. Evan Johnson, Andrea H. Bild

Faculty Publications

Background: The growth factor receptor network (GFRN) plays a significant role in driving key oncogenic processes. However, assessment of global GFRN activity is challenging due to complex crosstalk among GFRN components, or pathways, and the inability to study complex signaling networks in patient tumors. Here, pathway-specific genomic signatures were used to interrogate GFRN activity in breast tumors and the consequent phenotypic impact of GRFN activity patterns.

Methods: Novel pathway signatures were generated in human primary mammary epithelial cells by overexpressing key genes from GFRN pathways (HER2, IGF1R, AKT1, EGFR, KRAS (G12V), RAF1, BAD). The pathway analysis toolkit Adaptive Signature …

Spengler's Worldview: A Retrospective Analysis, Rudolph Zalter

Comparative Civilizations Review

No abstract provided.

Full Issue, Comparative Civilizations Review

Comparative Civilizations Review

No abstract provided.

Civilizational Analysis And Paths Not Taken, Part Ii: The Great Divergence, Toby Huff

Comparative Civilizations Review

The current president of the Association and noted scholar in the foundations of modern science discusses the evolution of distinct civilization with stress on Islamic and Chinese civilizations. The article covers three encounters that have occurred in history between different civilizations. The first encounter was between Byzantium and the Islamic World in the 9th and 10th century; the second was the interaction between the West and Islam in the 12th century, and the third was between European missionaries and China after 1400. His conclusion is that despite cross-pollination in various areas, the basic features of the Islamic and Chines cultures …

Probing The Effects Of Surface Hydrophobicity And Tether Orientation On Antibody-Antigen Binding, Derek B. Bush, Thomas A. Knotts Iv

Faculty Publications

Antibody microarrays have the potential to revolutionize molecular detection for many applications, but their current use is limited by poor reliability, and efforts to change this have not yielded fruitful results. One difficulty which limits the rational engineering of next-generation devices is that little is known, at the molecular level, about the antibody-antigen binding process near solid surfaces. Atomic-level structural information is scant because typical experimental techniques (X-ray crystallography and NMR) cannot be used to image proteins bound to surfaces. To overcome this limitation, this study uses molecular simulation and an advanced, experimentally validated, coarse-grain, protein-surface model to compare fab-lysozyme …

Thermal Characterization Of Natural And Synthetic Spider Silks By Both The 3Ω And Transient Electrothermal Methods, Troy Munro, Changhu Xing, Heng Ban, Cameron G. Copeland, Randolph V. Lewis, Colby Jensen

Faculty Publications

Thermal conductivity, thermal diffusivity and volumetric heat capacity of three spider silks are measured in this paper as a benchmark for further studies. These silks include the major and minor ampullate silks of the Nephila clavipes spider, and a synthetic spider silk fiber made from recombinant dragline silk proteins purified from transgenic goats’ milk. Two complementary measurement techniques are employed in the thermal characterization of these microscale single fibers for self-verification. One is the transient electrothermal technique (TET) and the other is the 3ω method. Experimental measurements indicate that thermal properties of the dragline silk are very close to those …

Investigation Of Synthetic Spider Silk Crystallinity And Alignment Via Electrothermal, Pyroelectric, Literature Xrd, And Tensile Techniques, Troy Munro, Tristan Putzeys, Michael Wubbenhorst, Christ Glorieux, Cameron G. Copeland, Randolph V. Lewis, Changhu Xing, Heng Ban

Faculty Publications

The processes used to create synthetic spider silk greatly affect the properties of the produced fibers. This paper investigates the effect of process variations during artificial spinning on the thermal and mechanical properties of the produced silk. Property values are also compared to the ones of the natural dragline silk of the N. clavipes spider, and to unprocessed (as-spun) synthetic silk. Structural characterization by scanning pyroelectric microscopy is employed to provide insight into the axial orientation of the crystalline regions of the fiber and is supported by XRD data. The results show that stretching and passage through liquid baths induce …

Lake Powell Food Web Structure: Predicting Effects Of Quagga Mussel, Joshua A. Verde

Theses and Dissertations

Food webs in aquatic ecosystems can be dramatically altered by invasive species. Quagga mussels are prevalent invaders that compete with existing species and disrupt nutrient cycling. In 2012, the Quagga Mussel (Dreissena rostriformus bugensis) was introduced into Lake Powell and is expected to move throughout the reservoir in the near future. Stable isotope analysis is a powerful tool for characterizing food webs and trophic interactions. To predict the long-term effects of Quagga Mussels, we used stable isotope analysis of primary producers, primary consumers, prey fish species, and predator fish species in Lake Powell to determine food web structure. …

Phylogenetics, Biogeography, And Patterns Of Diversification Of Geckosacross The Sunda Shelf With An Emphasis On The Genuscnemaspis (Strauch, 1887), Perry Lee Wood

Theses and Dissertations

In my dissertation I investigate two genera of geckos (Cyrtodactylus and Cnemaspis) that are distributed across Southeast Asia with an emphasis on Cnemaspis. In Chapter 1 I use a multilocus dataset, ancestral area analyses, and molecular clock dating to generate a species level time calibrated phylogeny to test the monophyly of Cyrtodactylus and to identify major biogeographical patterns. I identified that Cyrtodactylus is monophyletic only if the the Sri Lankan genus often recognized as Geckoella is included. The results of the Biogeographical analyses reveal a west to east pattern of diversification. Chapter 2 I use a traditional morphological dataset to …

The Mediating Role Of Relational Aggression Between Neuroticism And Couple Attachment And Relationship Quality In Long-Term Committed Relationships, Sarah Annis Eliason

Theses and Dissertations

Much of the literature regarding relational aggression in romantic relationships has focused on the behaviors and outcomes of the actor and victim independently. Additionally, the relationships studied usually cover emerging adult samples, and rarely expand to long-term committed relationships, such as cohabiting or married couples. In this paper I sought to determine if relationally aggressive behaviors in long-term committed relationships over time resulted as a function of individual predictors (e.g. neuroticism), or as a process of couple interactions (e.g. couple attachment); and how these traits directly and indirectly (through relational aggression) influenced relationship quality. An Actor Partner Independence Model (APIM) …

The Perceptual Learning Style Preferences Of Hispanic Students In Higher Education, Catherine Johnston Lui

Theses and Dissertations

This paper addresses the question of whether higher education Hispanic students of different nationalities have different perceptual learning style preferences. Independent samples t-tests findings suggest the country of origin of a Hispanic student's parents has a statistically significant relationship (n=165, p<0.0073) with student's learning style preferences. ANOVA results also identified a statistically significant relationship between SES and group learning style (p<0.004,) and between visual learning style and two factors: age (p<0.011) and family education (p<0.033).

Differences In The Motivations Of Chinese Learners Of English In Different (Foreign Or Second Language) Contexts, Rui Li

Theses and Dissertations

This study employed the L2 Motivational Self-System (Dörnyei, 2005) as a framework to compare differences in the types of motivation reported by Chinese learners of English in a foreign language context (China) and a second language context (USA). It followed up on studies by Taguchi, Magid, and Papi (2009) and You and Dörnyei (2016). The participants consisted of 61 current students at an American university who come from Mainland China. This study adopted a mixed-method approach, using an internet-based questionnaire followed by an individual interview. The investigation aimed to explore what types of English learning motivation Chinese students have in …

Are Cardiovascular Disease Inflammatory Markers Elevated In Those With Nonspecific Chronic Musculoskeletal Pain Compared To Nonpain Case Controls?, Jeffrey Ray Tolley

Theses and Dissertations

CONTEXT: Recent studies have considered the role of inflammation in the development of both cardiovascular disease (CVD) and musculoskeletal conditions, such as rheumatoid arthritis. Studies suggest that inflammation plays a significant role in the development of cardiovascular disease. In conditions of chronic pain, as with rheumatoid arthritis, inflammation has also been noted through elevated levels of inflammatory markers. There are currently no studies that examine the possible connection between inflammatory markers related to increased risk of cardiovascular disease and nonspecific chronic musculoskeletal pain (NCMP). OBJECTIVE: The purpose of this study was to determine whether urinary levels of microalbumin (MA) and …

Ecological And Genetic Variation Among Populations Of Boechera Caeruleamontana Sp. Nov. (Brassicaceae) From Blue Mountain And Dinosaur National Monumentin Eastern Utah And Western Colorado, Melissa Snyder

Theses and Dissertations

Boechera is a large genus of flowering plants whose taxa are found primarily in North America. Boechera vivariensis (S.L. Welsh) W.A. Weber (the Park rockcress) is restricted to the Uintah Basin on Weber sandstone substrates in the vicinity of Dinosaur National Monument and Blue Mountain. The nomenclature of Park rockcress is significantly impacted by the discovery that the type collections of the taxon represent a rare, apomictic diploid resulting from the hybridization between B. thompsonii and an undescribed sexual diploid (to be called Boechera caeruleamontana sp. nov. Allphin and Windham). As a result, greater information is needed regarding how B. …

Decellularization And Recellularization Processes For Whole Porcine Kidneys, Nafiseh Poornejad

Theses and Dissertations

Concern over kidney disease has increased dramatically in recent years within the medical community. It is estimated that approximately one in fifteen Americans, nearly 20 million people, experience chronic kidney disease with most of those diagnosed progressing to kidney failure. The ultimate treatment available for end stage renal failure is whole kidney transplantation. However, there are very few kidneys available for patients to receive and those patients who are fortunate enough to receive an organ must remain on immunosuppressive medication for the remainder of their lives. The United States Department of Health & Human Services have reported that 18 people …

Nabataean Subadult Mortuary Practices, Courtney Dotson Ewert

Theses and Dissertations

This thesis provides the beginnings of further research on the correlation between Nabataean mortuary practices and specific biological age ranges. It seeks to answer the question of whether Nabataean infants were absent from, or under-represented, in Nabataean cemeteries. Several quantitative analyses and descriptive statistics were performed, comparing Nabataean adult and subadult burials from fourteen sites. Nabataean cemetery populations were also compared with Walter Scheidel's model life table. These analyses demonstrate that Nabataean burials typically consisted of either a single adult or multiple individuals of various age ranges. Subadults, individuals under the age of 20 years, were rarely found buried by …

Smartphone Usage And Religiosity In Lds Young Adults, Matthew R. Fereday

Theses and Dissertations

This study sought to identify any smartphone usage with significant positive or negative relationships with the religiosity of LDS young adults, with the hypothesis that smartphone usage would indeed have significant relationships with religiosity, both positively and negatively. Over 1,000 BYU students were surveyed for their usage of 36 popular and religious apps and of 33 different categories of content consumption, their content sharing, and compulsive use. That data was compared with their private religiosity (prayer, scripture study, and thinking seriously about religion) and religious experience (strength of beliefs, feeling the Spirit, finding strength through their faith, etc.) BYU students' …

Women In Community Corrections In New York City: Hiv Infection And Risks, Nabila El-Bassel, Phillip Marotta, Stacey Shaw, Mingway Chang, Xin Ma, D Goddard-Eckrich, Tim Hunt, Karen Johnson, Sharun Goodwin, Maria Almonte, Louisa Gilbert

Faculty Publications

Although the incidence of HIV among women on probation, parole and alternatives to incarceration programs is significant to public health, drivers of this concentrated epidemic among women under community corrections remain understudied. This study examined prevalence of HIV and sexually transmitted infections and the associations between substance use, sociodemographic factors and the prevalence of biologically-confirmed HIV and other sexually transmitted infections among a sample of 337 substance-using women recruited from community correction sites in New York City. Prevalence of HIV was 13% and sexually transmitted infections was 26% (Chlamydia, trachomatis and Neisseria gonorrhea). After adjusting for covariates, HIVpositive women were …

A Geospatial Model For Characterizing The Fish Resources Of The Similkameen River, British Columbia, Canada, Ning Liu, Andrew Harwood, James Kells, Karl-Erich Lindenschmidt

Open Water Journal

A geospatial model was been developed in order to rapidly characterize fluvial geomorphological features associated with the fish resources in a river system. The model uses four easily-quantified geospatial attributes – channel width, plan view sinuosity, longitudinal slope and fractal dimension – for classifying a stream channel into geomorphic response units (GRUs), which are the key working elements of the geospatial model used in this work. Using the geospatial model, a total of five GRUs were defined along the river channel. The model framework was tested using data from a 1983 fish survey conducted along the Canadian portion of the …