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Family Environments And Children's Cognitive Skills: Accounting For Heritable Influences Through Comparing Adopted And Biological Children, Shelby Mae Mcneill

Theses and Dissertations

Utilizing ECLS-K:2011 data, this study compares adopted and biological children to account for the role of heritable characteristics in explaining the relationship between family environments and children's cognitive skills. I find that cognitive skills do not differ across adopted and biological children after adjusting for the systematic differences between them. I also find that the relationship between family environment and children's cognitive skills does not differ across adopted and biological children. Taken together, these results suggest that the relationship between family environment and children's cognitive skills is not spurious.

Marital Quality And Cardiovascular Risk In Women During The Menopausal Transition, Tracy E. Brown

Theses and Dissertations

Marital quality is linked to health benefits for men and women. Although women have less risk factors than men for cardiovascular disease prior to menopause, their risk increases substantially after menopause. The purpose of this study was to assess the impact of marital quality and vasomotor symptoms on cardiovascular risk factors including C-reactive protein (CRP) and carotid intima-media thickness (cIMT) in women before, during, and after the menopausal transition. The final sample consisted of 92 married women between the ages of 40 and 60 years. Hypotheses were tested using hierarchical regression and general linear modeling. Results suggest that greater marital …

The Relationship Between Auditory Habituation And Anxiety In Autism Spectrum Disorder, David Nicholas Top

Theses and Dissertations

Many individuals with autism spectrum disorder (ASD) have atypical sensory processing and behaviors including sensory sensitivity and low registration of sensory stimuli as well as sensory seeking and avoiding behaviors. Additionally, many individuals with ASD have clinically distressing levels of anxiety. Previous research suggests that there is a link between abnormal sensory processing, anxiety, and ASD. The purpose of this study was to experimentally observe auditory sensory processing using pupillometry methods, between ASD, control, and high-anxious control groups. While a difference in tonic pupil size was observed, there were no reactivity or habituation differences between the groups. There were no …

Survivors' Perceptions Of Support Following A Parent's Suicide, Suzanne Nicole Bennett

Theses and Dissertations

Children who experience a parent's death by suicide are a vulnerable population at risk for emotional and mental health issues as well as suicide attempts (Cerel, Fristad, Weller, & Weller, 1999; Kuramoto et al., 2010; Wilcox et al., 2010). Yet, in spite of the knowledge that effective postvention is in reality prevention (Cerel et al. 2008), relatively little is known about these children and adolescents, particularly regarding their experiences following the suicide. The current research study investigated which resources, assistance, and actions of those around the child were perceived as most helpful and unhelpful following the parental suicide. Through semi-structured …

Fundamental Studies And Applications Of Ambient Plasma Ionization Sources For Mass Spectrometry, Wade C. Ellis

Theses and Dissertations

The field of ambient desorption/ionization mass spectrometry (ADI-MS) has existed for over a decade. ADI-MS is a technique that offers benefits including fast analysis time, simple ionization sources that are easily constructed, and little to no required sample preparation. The research presented here describes efforts to better understand plasma-based ADI-MS sources and to explore the use of hydrogen-doped plasma gases with these sources. The use of hydrogen-doped argon (H₂/Ar) and hydrogen-doped helium (H₂/He) as plasma gases for a dielectric barrier discharge (DBD) and an AC glow discharge is presented first. When using the DBD, the intensity …

Lithofacies And Sequence Architecture Of The Lower Desert Creek Sequence, Middle Pennsylvanian, Aneth, Utah, Chanse James Rinderknecht

Theses and Dissertations

Middle Pennsylvanian (Desmoinesian) strata of the Lower Desert Creek (LDC) sequence within the sub-surface Greater Aneth Field (GAF) reflect a hierarchy of 4th and 5th order carbonate-dominated cycles. The Lower Desert Creek sequence, along the studied transect are composed of eight carbonate facies deposited on an east-facing shelf. There is a lateral transition from open marine algal buildup from the southeast (cores R-19, Q-16, O-16, and J-15) to a more restricted lagoonal environment to the northwest (core K-430 and E-313). The Lower Desert Creek sequence within the GAF contains three main parasequence sets: a basal, relatively deep-water unit (LDC 1), …

The Effects Of Income And Ethnicity On Health Outcomes Of Mexican Immigrant And Anglo Women, Andrea M. Debarros

Theses and Dissertations

The Hispanic Paradox is the finding that Hispanic immigrants living in the United States have better health than Anglo Americans despite being socioeconomically disadvantaged (Crespo et al., 1996; Stern et al., 1999; Sundquist et al., 1999; Dixon et al, 2000; Lariscy et al., 2015; Overton et al., 2015; Thomson et al., 2013). The literature surrounding the Hispanic Paradox has studied these effects primarily in Mexican-American Immigrant populations (Sundquist et al., 1999; Dixon et al, 2000; Lariscy et al.); however, additional research has found similar findings for various other Hispanic countries such as Cuba and Puerto Rico (Abraido-Lanza, A F. et …

Bacterial Community Ecology Of The Colon In Mus Musculus, Rachel Marie Nettles

Theses and Dissertations

The gut microbiome is a community of closely interacting microbes living in the gastrointestinal tract. Its structure has direct relevance to health. Disturbances to the microbiome, such as due to antibiotic use, have been implicated in various diseases. The goal of this study was to determine how the gut microbiome reacts to and recovers from disturbance caused by antibiotics. Because diet also influences the microbiome, this study included the interaction between diet and antibiotics. Half of the mice in each diet treatment were given antibiotics to disturb their microbiomes. After cessation of antibiotics, mice were paired in combinations within diets …

Modulation Of Synaptic Plasticity: Endocannabinoids And Novel G-Protein Coupled Receptors Expression And Translational Effects In Interneurons, Katrina M. Hurst

Theses and Dissertations

Learning and memory are important processes that occur in the brain. The brain is comprised of neurons that make connections with each other known as synapses. Synaptic plasticity is widely believed to be the physiologic mechanism by which learning and memory occur. Synapses can either be strengthened through a process known as long-term potentiation (LTP) or weakened through long-term depression (LTD). The area of the brain that is most studied for its role in learning and memory is the hippocampus, which has been shown to be involved in memory consolidation. The detection of endocannabinoids and their receptors has opened a …

Function Of Ric-8a In G Protein E+- Subunit Biogenesis, Barry Willardson

Journal of Undergraduate Research

1. Grant Ludlam. The MEG award helped support Grant’s work from January 2015 through August 2016. During this time Grant has worked on three projects. He investigated the role of Ric8A in the folding of the G protein a subunit and its assembly into the G protein heterotrimeric complex. Unfortunately, his results showed that deletion of Ric8A in the photoreceptor cells of mice did not affect G protein signaling. As a result, he changed his research focus to determining the structure of the BBSome core complex. He assisted a graduate student, Takuma Aoba, in this work. They used a combination of …

Mentoring Undergraduates At The Intersection Of Organic Synthesis And Peptide Science, Steven L. Castle

Journal of Undergraduate Research

Our academic goals were threefold. First, we aimed to synthesize building blocks and begin assembling them to construct the anticancer peptide yaku’amide A (YA, Figure 1). Our purposes in synthesizing YA were to develop new chemical reactions suitable for efficiently preparing its unusual amino acids (shown in red and blue in Figure 1), and synthesize simplified analogues for use in studies designed to reveal its biological target and mode of action. Our second academic goal was derived from the first and involved investigating the ability of bulky dehydroamino acids (i.e., the amino acids of YA shown in blue in Figure …

Seasonal Progression Of Aquatic Organisms In A Temporary Wetland In Northern California, Michael G. Peterson, Kevin B. Lunde, Ming-Chih Chiu, Vincent H. Resh

Western North American Naturalist

Seasonal wetlands are important habitats for biodiversity of both invertebrate and vertebrate fauna. Many aquatic species have life history traits adapted to colonizing and developing in temporary aquatic habitats, and these traits influence the annual succession of the macroinvertebrate community. The chronology of taxon appearance and the variation in relative abundances during the hydroperiod are important for understanding population dynamics, trophic interactions, and responses to drought. This study investigated the successional changes in macroinvertebrate abundances in a seasonal wetland in northern California. Water quality parameters were measured regularly, including dissolved oxygen, temperature, pH, surface area, and specific conductance during the …

Rebuilding Kidneys, Alonzo D. Cook, Deverly L. Roeder, Jonathan J. Wisco

Journal of Undergraduate Research

The motivation for this work was the tremendous need for replacement kidneys. End-stage renal disease (ESRD) affects over 500,000 patients in the U.S. and costs Medicare $30 Billion annually for dialysis and transplant procedures. Our overall objective was to engineer kidneys from decellularized porcine extracellular matrix (DPECM) scaffolds and cell cultures grown from human progenitor cells. The primary reason for using human cells was to develop non-immunogenic kidneys that can be used to treat the more than 100,000 chronic kidney disease (CKD) patients awaiting a transplant, thus obviating the need for post-transplant immunosuppressive therapy and the associated risks of acute …

Oxytocin And Infant Development: A Study Of The Genetic Underpinnings Behind Social Behavior In Rhesus Macaques, Spencer Waters, James Dee Higley

Journal of Undergraduate Research

It is widely accepted that the neuropeptide oxytocin helps mediate pro-social behavior and bonding between humans as well as other primates. Current genetic research has shown a link between variants in the oxytocin receptor gene (OXTR) and measures of social skills in humans. Demonstrating a link between oxytocin genotype and sociality, implies biological underpinnings for social bonding and affiliation in both human and nonhuman primates, suggesting that neurophysiological mechanisms may function to modulate a wide variety of social behaviors.

Differential Number Of Days Lived Among Utah Centenarians, Haley Bronson, Jeremy Yorgason

Journal of Undergraduate Research

As a result of the nearly 77 million people born during the Baby Boom, older adults are the fastest growing segment of the population in the United States¹. Centenarians, those who live to be 100 years of age or older, are a burgeoning subgroup of the older adult population. They surpass the current life expectancy by 20 to 25 years. There is increasing interest regarding the antecedents to “ageing well” and the factors that hinder it. Insecure attachment and loneliness have been found to be related to lower well-being in older adults², as well as functional …

Effects Of Tetrabenazine On Basal Methamphetamine, Taylor Tribett, Scott Steffensen

Journal of Undergraduate Research

It is easy to see how much METH hurts the lives of its users and leads to high costs for society. Methamphetamine abuse is linked to higher healthcare costs, child abuse, and higher rates of theft and incarceration (Dobkin & Nicosia, 2009). Additionally, prescriptions for amphetamines (which are theorized to work by the same mechanisms) almost doubled in the United States between 2006 and 2011 (Sembower, Ertischek, Buchholtz, Dasgupta, & Schnoll, 2013). As the presence of these drugs becomes more widespread, the number of those at risk for abuse and addiction increases as well. In order to develop pharmacological treatments …

Methamphetamine-Induced Melanization In Dopamine Cell Culture, Rebecca Oliphant, Scott Steffensen

Journal of Undergraduate Research

Dopamine (DA) neurons are at the core of many highly-researched diseases. Dopaminergic neuronal degeneration has been linked to oxidative stress, a state that occurs when high levels of normally-occurring reactive oxidative species (ROS) are formed. Depending on the location of such degradation, the result could be either Parkinson’s disease or the very common state of addiction and withdrawal.

Neuromelanin is a dark polymer pigment found on some catecholaminergic neurons and contains a stable radical that is able to inactivate ROS and possibly protect DA neurons from degradation. The mechanism for spontaneous melanization is unknown, but an understanding of this process …

What Happens When Remember The Wrong Thing: The Effects Of False Recognition On Memory Performance, Amanda Ellgen, C. Brock Kirwan

Journal of Undergraduate Research

Our long-term memory system has the impressive ability to form unique representations of events and later retrieve those distinct events with minimal interference from similar events. For example, you may park in the same parking lot everyday, but in a different spot each time. Most days, you can remember specifically where you are parked even though each encounter is very similar and thus might interfere with all the others. Computational models of brain functioning propose that this ability depends on the complementary processes of pattern separation and pattern completion. Pattern separation is the process whereby overlapping representations (of, for example, …

Weak Synchronization In Excitatory – Inhibitory Neuronal Networks, Joel Eliason, Benjamin Webb

Journal of Undergraduate Research

One ubiquitously observed dynamic phenomenon in the nervous system is that of weak synchronization or clustering, a behavior in which a large group of neurons in a population will all fire synchronously and then fall out of synchronization. When isolated to neurons that only form short-range connections, this behavior is typically referred to as “neuronal avalanches”, and is thought to be particularly important for robustness of information transmission as well as sensitivity to inputs. Given these potential computational benefits, avalanches have been a focus of theoretical biologists for the past 20 years. In particular, my project focused on the conditions, …

Electronic Structure And Quassiclassical Dynamics Of [2+2] Tetrafluoroethylene Cycloaddition Reactions, Steven Jones, Daniel Ess

Journal of Undergraduate Research

Cycloaddition reactions are key reactions used to construct complex cyclic scaffolds (large networks of carbon atoms that can be used in catalysis, synthesis, etc.). While classical reactions that form 6-membered rings are well-known and generally have a one-step reaction mechanism, 4-member ring-forming reactions are much less used, but could be very valuable for the construction of cyclobutane structures.

Tetrafluoroethylene (TFE) is used on a large scale by Dow and other chemical companies to form hydrofluoro compounds such as teflon. The current understanding of the mechanism of cycloaddition reactions with TFE is limited. Standard hydrocarbon reactions proceed via a welldocumented, concerted …

Development And Application Of Minimum Energy Crossing Point Software Suite For Organometallic Reactions, Justin Snyder, Daniel H. Ess

Journal of Undergraduate Research

Computational studies are critical to the field of organometallic chemistry since many highly reactive and unstable compounds cannot be isolated or observed experimentally. It is well-known that many organometallic reaction mechanisms involve spin intersystem crossing, e.g. singlet to triplet conversion. To estimate the rate of intersystem crossing it is useful to calculate electronic structures where spin states and their energies are degenerate, which is called a “minimum energy crossing point (MECP).” Prior to the completion of this project, there was only one working program that interfaced with the Gaussian 09 electronic structure package for the calculation of minimum energy which …

Byu Stamp Scavenger Hunt, Mandy Elsmore, Gary Barton

Journal of Undergraduate Research

The goal of this project was to provide an informative and unifying activity for BYU students through an art installation and exhibition. It was inspired by Japanese Eki (Train) Station stamps, which promotes tourism throughout all of Japan, to popular and unknown areas, due to people interest in collecting ink stamps placed at each station. I thought creating a stamp scavenger hunt throughout BYU campus would help students to get to know campus better and the different departments within them. Speaking from my own personal experience, it was not until this project that I really got to know BYU campus. …

Estimating Ages Of Utah Chubs By Use Of Pectoral Fin Rays, Otoliths, And Scales, Kayla M. Griffin, Zachary S. Beard, Jon M. Flinders, Michael C. Quist

Western North American Naturalist

Utah chub Gila atraria is native to the Upper Snake River system in Wyoming and Idaho and to the Lake Bonneville Basin in Utah and southeastern Idaho. However, the Utah chub has been introduced into many other waterbodies in the western United States, where it competes with ecologically and economically important species. The objectives of this study were to evaluate between-reader precision and reader confidence in age estimates obtained from pectoral fin rays, lapilli (otoliths), asterisci (otoliths), and scales for Utah chubs collected from Henrys Lake, Idaho. Lapilli have been previously shown to provide accurate age estimates for Utah chubs; …

Current And Future Prospects Of The Biological Diversity Of Vertebrates In Teh Protected Areas Of A Megadiverse Country: Ecuador, Benjamin Bay, Dr. Jack Sites

Journal of Undergraduate Research

I collected, cleaned, and organized data on animal species in Ecuador, a megadiverse country (harbors a vast proportion of Earth’s species and is home to high numbers of endemic species). These data were crucial for a larger project which modeled the impacts of climate change on species conservation over time. I designed the algorithms that cleaned and organized these large data sets.

Defining Nkx6.1 Binding Partners In Young And Aged Pancreatic Islet, Sean Kang, Dr. Jeffery Tessem

Journal of Undergraduate Research

Diabetes is an increasing epidemic that deserves more attention. Those affected by diabetes are restricted to either strict diets or remedial insulin supplementation. Both Type 1 and Type 2 diabetes are directly related to a decrease in functional β-cell mass. Exciting research has revealed Nkx6.1 to be an influential transcription factor which induces β-cell proliferation, protects against apoptosis and enhances insulin secretion when overexpressed 1 . Our recent findings indicate significant β-cell proliferation is limited to β-cells from adolescent rats, with a severe decrease in proliferation as the animal ages. 2 Nkx6.1 expression is present in every stage of development, …

Quantifying The Efficiency Of Heterobimetallic Complexes, Ryjul Stokes, David Michaelis

Journal of Undergraduate Research

Transition metal catalysts have revolutionized the efficiency by which pharmaceuticals and other value added products are synthesized due to their unique ability to activate small molecules and drive the formation of new C-C and C-N bonds. In particular, the direct functionalization of olefins with transition metal catalysts is a powerful method of converting simple, cheap building blocks into more complex molecules. The challenge is that many ligands that control reaction selectivity often decrease the electrophilicity of the catalyst. Heterobimetallic complexes containing an early/late transition metal pair could provide a solution to this challenge by providing a new way to activate …

Microwave Promoted Iminyl Radical Cyclization, Aaron Kubosumi, Steven L. Castle

Journal of Undergraduate Research

Pyrrolidines and their derivatives are found in many biologically active compounds, such as Lipitor and Atorvastatin, which possess a wide variety of remarkable pharmaceutical properties. Therefore, the efficient synthesis of functionalized pyrrolidines is of great value to organic chemists. Multiple attempts have been made to synthesize compounds containing pyrrolidine ring systems. Walton 1 utilized radical cyclization, via microwave heating, to transform Ophenyl oximes with terminal alkenes to dihydropyrroles, compounds closely related to pyrrolidines. Similarly, Sammis 2 proposed a method involving radical cyclizations of azidederived aminyl radicals onto silyl enol ethers. Unfortunately, the method proposed by Sammis requires highly toxic and …

Determining The Structure Of The Bbbsome, Grant Ludlam, Barry Willardson

Journal of Undergraduate Research

Bardet-Biedl Syndrome (BBS) occurs when an eight-protein complex called the BBSome is improperly assembled and can no longer function. The BBSome is responsible for trafficking membrane proteins to cilia, a projection from the cell surface packed with receptors that allow the cell to sense its surroundings. Loss of BBSome function causes malformation of cilia and leads to vision loss, obesity, kidney disease and mental retardation.

The Total Synthesis Of Yaku’Mide A, Shi Luo, Steven Castle

Journal of Undergraduate Research

Yaku’amide A (YA) has potent toxicity against cancer cells (IC50 = 14 ng/ml against P388 murine leukemia cells). Ueoka et al.1 first reported the isolation of YA from a marine sponge in the East China Sea. They used spectroscopy and chemical degradations to analyze its structure. YA contains unique dehydroamino acids (See Figure 1). In the growth inhibition study, YA showed unique activity against 39 cancer cell lines, indicating a novel mode of action. The unusual structure of YA and its prominent biological activity has attracted research groups from around the world to address its synthesis.

A Microfluidic Approach To Measuring Endothelial Cell Migration

Journal of Undergraduate Research

Pathological angiogenesis or new vessel growth plays a key role in a number of diseases including tumor growth and several eye diseases that can lead to blindness. While antiangiogenic therapies have been developed for many of these pathologies, there remains a pressing need for more effective anti-angiogenic therapy with fewer side-effects. Capillary morphogenesis gene 2 (CMG2) has been shown to play an important role in angiogenesis and is a potential target for future anti-angiogenic therapies. To better understand the physiological role of CMG2 and to accurately compare how well different CMG2 antagonists inhibit endothelial cell migration (the putative mechanism for …