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Design And Synthesis Of Ceragenins–Cationic Steroid Antimicrobial Compounds, Structural Improvement And Synthesis Of Cyclopentenone Prostaglandins And Modification And Synthesis Of Derivatives Of Ribityllumazines: Potential Antigens For Activation Of Mait Cells, Yubo Li

Theses and Dissertations

Antimicrobial peptides (AMPs) are ubiquitous and display broad-spectrum antimicrobial activity that can control bacterial colonization of surfaces. Ceragenins are small-molecule mimics of AMPs and have several advantages over AMPs, including cost of manufacture and stability. A ceragenin, CSA-120, modified with an acrylamide group was directly incorporated into fluoropolymer coatings as a means of inhibiting bacterial biofilm formation. The ceragenin-containing coatings displayed improved performance. By conjugating a copper chelating group to the ceragenin, chelation of 64Cu by the conjugate was effective and provided a stable complex that allowed in vivo imaging. This conjugate may provide a means of identifying infection sites …

Comparative Civilizations Review No. 80 Full Issue, Comparative Civilizations Review

Comparative Civilizations Review

No abstract provided.

Comparing Academic Vocabulary List (Avl) Frequency Bands To Leveled Biology And History Texts, Lynne Crandall

Theses and Dissertations

For decades, teachers and language learners have been concerned about matching the difficulty level of texts to the proficiency level of learners in order to achieve comprehensible input, which leads to effective learning. Some leveling systems and research use word lists as part of their leveling processes, particularly the Academic Word List. The Academic Vocabulary List (AVL) has not been explored yet as a leveling tool, so this study aims to address this lack of research by examining how the AVL words vary in cumulative frequency bands and also in separate frequency bands with regard to level and topic. The …

Regulation Of Immune Cell Activation And Functionby The Nbmpp2 Protein Andthe Cd5 Co-Receptor, Claudia Mercedes Freitas

Theses and Dissertations

According to the centers for disease control and prevention (CDC) and the world healthorganization (WHO), heart disease and immune related diseases such as diabetes and cancer areamong the leading causes of death around the world. Thus, the regulation of the function ofimmune cell plays a key role in health and disease. Calcium (Ca2+) ions play a critical role inimmune cell activation, function and in a robust immune response. Defects in Ca2+ signalinginfluences the development of cardiac disease, Alzheimer disease, immune cell metabolism,muscle dysfunction, and cancer. Each immune cell is unique in its activation and function,making it relevant to understand how …

Major Decisions: Religious Women And Their Perceptions Of Women In Stem Majors, Mandy Lou Pershing

Theses and Dissertations

Women still lack representation in many Science, Technology, Engineering, and Math (STEM) fields, particularly those with high earning potential. Past studies on women who study STEM have failed to acknowledge the impact of religious values on choice of major among women. Using data collected at a religiously-affiliated university in 2013, this study explores how 24 religious women made decisions about majoring in STEM fields. The results from this sample closely follow the literature review, while also adding many new layers to understanding how religious women make decisions about STEM. Themes identified using this approach are useful for designing future studies …

Effect Of Cuff Pressure On Blood Flow During Blood Flow-Restricted Rest And Exercise, Kent Westerberg Crossley

Theses and Dissertations

Purpose: The purpose of this study was to investigate the blood flow/pressure relationship (linear or nonlinear) in the superficial femoral artery when seated, as well as to investigate blood flow changes with exercise using varying cuff pressures and a preexercise (PE) condition. The presence of venous outflow with occlusion at rest and exercise was also investigated.Methods: Twenty-three subjects visited the lab on 3 occasions. First to determine linearity of blood flow using 0% to 90% arterial occlusion pressure (AOP), and venous outflow at rest and during exercise with cuff inflated to 40% AOP. Subsequent visits compared blood flow between rest …

Evaluating Fungal Pathogen Inoculum Loads In Field Seed Banks, Taryn Lori Williamson

Theses and Dissertations

Quantification of soilborne pathogen inoculum loads is important in both agricultural and wildland settings. Quantitative Polymerase Chain Reaction (qPCR) methods using SYBR Green chemistry have been shown to be useful for quantifying fungal inoculum loads in environmental samples. The purpose of this study was to develop a method to quantify fungal pathogen inoculum loads in soil seed banks using a qPCR method with SYBR Green chemistry. The invasive annual grass Bromus tectorum was chosen for this seed bank study. There were three objectives: 1) to design target-specific primers for three fungal pathogens known to be important in Bromus tectorum seed …

Multispecies Character Displacement In Mexican Poeciliopsis Fishes, Andrea J. Roth

Theses and Dissertations

Competition has long been recognized as a central force in shaping evolution, particularly through character displacement. Yet research on character displacement is biased as it has focused almost exclusively on pairs of interacting species while ignoring multispecies interactions. Unfortunately, communities are seldom so simple that only pairs of species interact, and it is not clear if inferences from pairwise interactions are sufficient to explain patterns in nature. A more realistic approach is to ask how traits evolve when multiple species interact. Here I explore the importance of multispecies competitive interactions on trait evolution in four congeneric species of livebearing fishes …

Antibacterial And Antifungal Activity Of Ceragenins, Mimics Of Endogenous Antimicrobial Peptides, Marjan Mohammadihashemi

Theses and Dissertations

The continuous emergence of drug-resistance pathogens is a global concern. As a result, substantial effort is being expended to develop new therapeutics and mechanisms for controlling microbial growth to avoid entering a "post-antibiotic" era in which commonly used antibiotics are no longer effective in treating infections. In this work, we investigate the efficacy and application of ceragenins as non-peptide mimics of antimicrobial peptides (AMPs). First, this work examines the susceptibility of drug-resistant Gram-negative bacteria. The susceptibility of colistin-resistant clinical isolates of Klebsiella pneumoniae to ceragenins and AMPs suggests that there is little to no cross-resistance between colistin and ceragenins/AMPs. Furthermore, …

Impacts Of Novel Fire And Herbivory Regimes On Snow-Waterresources And Resilience Of Aspen Forests, Jordan Daniel Maxwell

Theses and Dissertations

Human activities and expansion have created novel disturbance patterns across Earth’s landscapes. Disturbance is an ecological interruption after which ecosystem recovery or transition into a new state can occur, affecting biodiversity, ecosystem functioning, and theavailability of ecosystem services. Fire and herbivory are two of the most widespread forces of disturbance which shape ecosystems globally. In temperate forest ecosystems, fire affects forest composition, which influences the diversity and resilience of ecosystems (chapters 1 and 2) and forest canopy structure, which is important to snowpack accumulation and the availability of water resources (chapters 3 and 4). In chapter one, the effects of …

Developmental Language Disorders And Reticence In Childhood, Aimee Diehl

Theses and Dissertations

Children with developmental language disorder (DLD) struggle in a variety of social contexts. These children display different forms of social withdrawal, the most prevalent being shyness which is behaviorally manifested as reticence. The goal of the current study was to further explore the relationship between DLD and reticence in children using a revised set of items from the Teacher Behavior Rating Scale (TBRS). A total of 220 children participated in the study. A univariate analysis of variance (ANOVA) was used to determine if there were significant differences related to group, age, and gender on reticence. Findings revealed a significant difference …

Moderating Influence As A Design Principle For Human-Swarm Interaction, C Chace Ashcraft

Theses and Dissertations

Robot swarms have recently become of interest in both industry and academia for their potential to perform various difficult or dangerous tasks efficiently. As real robot swarms become more of a possibility, many desire swarms to be controlled or directed by a human, which raises questions regarding how that should be done. Part of the challenge of human-swarm interaction is the difficulty of understanding swarm state and how to drive the swarm to produce emergent behaviors. Human input could inhibit desirable swarm behaviors if their input is poor and has sufficient influence over swarm agents, affecting its overall performance. Thus, …

“Thy Troubles To Bless”, Jeffery S. Mcclellan

Religious Educator: Perspectives on the Restored Gospel

Dark clouds filled the Provo sky on April 15, 2003. It was the due date for our second daughter, but there were still no signs of imminent delivery. My wife, Christine, was concerned that she had not felt the baby move for a day or so. She felt urgently that we needed to go to the hospital for a test. I thought she was overly cautious, but we went.

What Happens Here Stays Here? Associations Between Choices During The Twenties And Flourishing Or Floundering During The Thirties, Melanie Lynn Lott

Theses and Dissertations

Life course theory suggests that an individual’s development is influenced by many factors such as one’s past choices and environment. The twenties are a period of great autonomy for many young people with opportunities to engage in choices with lasting consequences, both positive (e.g., furthering education, volunteering) and negative (e.g., crime, risky sexual behavior, heavy video game use). The current study explored the relationship between behaviors during one’s twenties and indices of adjustment (i.e., life satisfaction, relationship satisfaction, and hope) and maladjustment (i.e., poor emotional health and regret) in one’s thirties. Additionally, as factors such as income and biological sex …

Skeletal Muscle Recovery And Vibration, Garrett Collier Jones

Theses and Dissertations

In the past decade there has been a significant increase in focus on the effect upper body vibration (UBV) has on the recovery of skeletal muscle after exercise-induced muscle damage. Recovery can be defined and investigated using a wide variety of methods. This study used three different measurements to track muscle recovery over 7 days following an exercise muscle damage protocol and applied vibration to a mathematical model. A visual analog scale (VAS) was used to measure muscle pain, a strain gauge was used to obtain maximum voluntary isometric contraction (MVIC) strength measurements, and shear wave elastography (SWE) represented muscle …

Sensory Acceptability And Nutrient Stability In Micronutrient-Fortified Soymilk Prepared In Small-Scale Batch Processes, Dallin Max Hardy

Theses and Dissertations

Fortified and unfortified soymilk were produced from the same production batches for comparative evaluation. Fortification included a comprehensive array of micronutrients of interest to community and humanitarian nutrition programs. The effects of time after fortification prior to cooling, cooling method, and light or dark refrigerated storage on the stability of 5 vitamins (vitamin A, vitamin C, thiamine, riboflavin, and folate) were investigated for both fortified and unfortified soymilk. Significant vitamin C loss (6%) and mild vitamin A isomerization occurred while soymilk was hot immediately following fortification. Cooling bottled soymilk in an ambient water bath or ice water bath made no …

Space Use And Annual Survival Of Hybridized Mouflon Sheep In Hawaii And Comparing Estimates Of Population Size Through Instantaneous Sampling And Photographic Capture-Recapture, Bradley Jay Adams

Theses and Dissertations

Significant efforts in conservation are devoted to the management and study of ungulates, due to their significant roles in ecosystems as well as their potential economic value. This is especially true for species considered exotic, such as mouflon sheep (Ovis musimon) in Hawaii. Effective management of an exotic species requires an understanding of ecological metrics such as space use, survival, and population size. We provided these metrics for a population of mouflon that have hybridized with feral sheep (Ovis aries) on the island of Hawaii. In Chapter 1, we quantified space use and annual survival of sheep in an area …

Molecular Methods For The Identification And Quantification Of Cyanobacteria In Surface Water Sources, Treyton Michael Moore

Theses and Dissertations

Geosmin is a strong musty-flavored organic compound that is responsible for many taste-and-odor events in surface drinking water sources like lakes and reservoirs. The taste threshold of geosmin for humans is lower than 10 ng/L. Traditional treatment methods will not remove geosmin to this level. Additional water treatment methods must be implemented to successfully remove the geosmin and its associated flavor and odor from drinking water. Furthermore, geosmin is produced by cyanobacteria somewhat sporadically, so it is difficult to predict when taste-and-odor events are going to occur. The difficulty involved with predicting geosmin events has led most water treatment facilities …

Model Testing Of Soil Bacteria Population Dynamics, Adam Harlan Heninger

Theses and Dissertations

This is one of the first time series studies of bacteria in soils supporting actively growing corn crops. Mathematically modeling bacteria population dynamics has the potential as a tool to more precisely assess the economic optimal nitrogen fertilizer rate for farmers. As a first step in this modeling effort, we examine the possibility that the bacteria population growth might be described by a dynamic model developed in the food sciences describing bacteria growth in food meant for human consumption. We make the assumption that air temperature above the soil can be used as an approximation for soil temperature. Also, because …

Exponential Stability Of Intrinsically Stable Dynamical Networks And Switched Networks With Time-Varying Time Delays, David Patrick Reber

Theses and Dissertations

Dynamic processes on real-world networks are time-delayed due to finite processing speeds and the need to transmit data over nonzero distances. These time-delays often destabilize the network's dynamics, but are difficult to analyze because they increase the dimension of the network.We present results outlining an alternative means of analyzing these networks, by focusing analysis on the Lipschitz matrix of the relatively low-dimensional undelayed network. The key criteria, intrinsic stability, is computationally efficient to verify by use of the power method. We demonstrate applications from control theory and neural networks.

Uniting And Dividing Influences Of Religion In Marriage Among Highly Religious Couples, Heather H. Kelley, Loren D. Marks, David C. Dollahite

Faculty Publications

Previous research has suggested that religion can be both helpful and harmful. However, much oof the research on religion and families has employed relatively simple, distal measures of religion and has focused on predominantly only one side of the dualistic nature of religion. Drawing upon interviews with 198 religious couples (N = 396 individuals), the purpose of this study was to better understand how religion can have both a unifying and a dividing influence on marital relationships. Three overarching themes, accompanied by supporting primary qualitative data from participants, are presented. These themes include (a) how religious beliefs unite and …

Paternal Self-Efficacy: A Parenting Resilience Factor For Fathers With Depression, Mark Herrick Trahan, Kevin Shafer

Faculty Publications

Parental depression has a negative effect on child development including mental and physical health, language and development, and externalizing and internalizing behavior. This quantitative research study examined the relationship between paternal self-efficacy (PSE) and parenting behaviors often associated with paternal depression. Data from the Survey of Contemporary Fathers were used and responses from self-identified fathers (n = 1,156) on paternal involvement, warmth, harsh parenting practices, and parenting self-efficacy were analyzed to assess the association between depression and PSE on fathering behavior. Ordinary least squares regression analysis indicated that depression was associated with harsh parenting and parenting warmth, while parenting self-efficacy …

First Photo Evidence Of The American Black Bear (Ursus Americanus) In The Southwestern Limit Of Its Distribution, Melany Aguilar-López, Jazmín L. Monter-Vargas, Cristian Cornejo-Latorre, Anuar Hernández-Saintmartin

Western North American Naturalist

We present the first photographic evidence of the American black bear (Ursus americanus) in the southwestern limit of its distribution, representing the second record from the state of Hidalgo and the first photographic evidence of a live specimen in Los Marmoles National Park. The black bear recorded in photographs and videos was a subadult male. A total of 51 photo captures of the black bear in oak and pine-oak forests were obtained in 4 localities of Los Marmoles National Park within an altitude range of 1566 m to 1915 m. It is important to implement an adequate management …

New Records For Douglas's Squirrel (Tamiasciurus Douglasii) In Two Mountain Ranges Of The Great Basin, Constance I. Miller, Kenneth T. Hickman

Western North American Naturalist

New records of Douglas’s squirrel (Tamiasciurus douglasii) document the species in 2 mountain ranges of the Great Basin where tree squirrels have not been previously reported, including 2 sites in the White Mountains, California, and 1 site in the Desert Creek Mountains, Nevada. In the White Mountains, squirrels were photographed by a camera trap on 9 different dates in winter and spring 2016–2017 at a site on the east side of the range crest near the Crooked Creek Field Station of the White Mountain Research Center (3125 m). In early winter 2018, two Douglas’s squirrels were observed and …

Eight New Provincial Species Records Of Mayflies (Ephemeroptera) From One Arctic Watershed River In British Columbia, Dezene P.W. Huber, Claire M. Shrimpton, Daniel J. Erasmus

Western North American Naturalist

We repeatedly sampled 8 sites on the Crooked River in British Columbia’s Arctic watershed for adult and nymph mayflies (Ephemeroptera) over the course of 2 years. Using taxonomic keys and DNA barcoding, we report 8 new species records for the province: 5 members of the family Baetidae (Acerpenna pygmaea, Baetis phoebus, Baetis vernus, Iswaeon anoka, and Procloeon pennulatum), 1 Heptageniidae (Leucrocuta hebe), 1 Leptohyphidae (Tricorythodes mosegus), and 1 Siphlonuridae (Siphlonurus alternatus). Three of these, Acerpenna, Iswaeon, and Leucrocuta, are also new genus records for the province. In total, we detected …

Notes On The Predation Of Rough-Footed Mud Turtles (Kinosternon Hirtipes) In West Texas, Usa, Steven G. Platt, Jennifer L. Smith, Thomas R. Rainwater, Wiebke J. Boeing

Western North American Naturalist

Little is known concerning predation of rough-footed mud turtles (Kinosternon hirtipes), a species of conservation concern in Texas, USA. During field studies conducted from 2007 to 2016, we documented 8 instances (1 juvenile, 2 males, and 5 females) of predation among individuals of one of the few (<10) remaining populations of K. hirtipes in Texas. Predation was attributed to raccoons (Procyon lotor; n = 5) and feral pigs (Sus scrofa; n = 2); the predator responsible for the death of one of the turtles could not be determined. Turtles are vulnerable to predation when exposed by low water levels …

Functional And Transcriptomic Characterization Of Carboplatin-Resistant A2780 Ovarian Cancer Cell Line, Tamara Viscarra, Kurt Buchegger, Ignacio Jofre, Ismael Riquelme, Louise Zanella, Michel Abanto, Alyssa C. Parker, Stephen R. Piccolo, Juan Carlos Roa, Carmen Ili, Priscilla Brebi

Faculty Publications

Background

Ovarian cancer is a significant cancer-related cause of death in women worldwide. The most used chemotherapeutic regimen is based on carboplatin (CBDCA). However, CBDCA resistance is the main obstacle to a better prognosis. An in vitro drug-resistant cell model would help in the understanding of molecular mechanisms underlying this drug-resistance phenomenon. The aim of this study was to characterize cellular and molecular changes of induced CBDCA-resistant ovarian cancer cell line A2780.

Methods

The cell selection strategy used in this study was a dose-per-pulse method using a concentration of 100 μM for 2 h. Once 20 cycles of exposure to …

Further Understanding Of Bacteriophages That Infect The Bacterial Family Enterobacteriaceae, Paul Flake

Undergraduate Honors Theses

Despite the eclectic nature of bacteriophage genomes, nucleotide comparison is an effective method for grouping phages into cluster and subcluster classifications. This process is facilitated by making preliminary cluster assignations based on the identity of the major capsid protein. As more phages continue to be sequenced and integrated into cluster/subcluster groupings, adjustments may need to be made to the genomic similarity percentages that have previously defined cluster/subcluster classifications. Implementing proteomic comparison in addition to nucleotide homology may provide added clarity to this process. Protein conservation and diversity among lytic phages that infect the bacterial family Enterobacteriaceae is discussed and the …

Program Coordinators’ Experiences With Introducing Parent-Focused Health Lessons To A Child-Centered Micronutrient Supplementation Program: An Exploration Of Recent Programmatic Changes In Liahona Children’S Foundation, Shannon Barham

Undergraduate Honors Theses

This paper utilizes survey responses from local coordinators of LCF, an international micronutrient supplementation humanitarian organization, to provide insight into the challenges and personal rewards of providing nutrition education to parents of malnourished children. LCF is based in Utah and operates in 19 countries throughout the world. LCF recently introduced a series of health lessons geared toward parents of malnourished children. A survey was sent to LCF workers in 12 countries in order to gather feedback about the health lessons. Qualitative survey responses are explored, and potential suggestions for future changes to the health lessons are proposed. Additionally, data gathered …

Computational Regiospecific Analysis Of Brain Lipidomic Profiles, Austin Ahlstrom

Undergraduate Honors Theses

Mass spectrometry provides an extensive data set that can prove unwieldy for practical analytical purposes. Applying programming and machine learning methods to automate region analysis in DESI mass spectrometry of mouse brain tissue can help direct and refine such an otherwise unusable data set. The results carry promise of faster, more reliable analysis of this type, and yield interesting insights into molecular characteristics of regions of interest within these brain samples. These results have significant implications in continued investigation of molecular processes in the brain, along with other aspects of mass spectrometry, collective analysis of biological molecules (i.e. omics), and …