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Defining Cheating Using Multiple Models, Krista Joy Dowdle Aug 2022

Defining Cheating Using Multiple Models, Krista Joy Dowdle

Theses and Dissertations

Extradyadic romantic behavior in committed relationships, referred to here as "cheating," is a common occurrence. For the purposes of this study, we define cheating as romantic or sexual behaviors that occur outside of a committed romantic relationship and that violate the expectations of the relationship. This definition can be broken down into two parts: the behavior that occurred and the judgment of whether that behavior constitutes cheating. Using a large sample (N = 1,020), we tested a measure that conceptualized cheating as composing explicit behaviors, categorical judgment of behaviors, and dimensional judgment of behaviors. Fit statistics were mixed and we …

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Are Canned Sardines Or Dry Cat Food More Effective As Bait For Capturing Northwestern Pond Turtles (Actinemys Marmorata) And Red-Eared Sliders (Trachemys Scripta Elegans)?, Alexandria M. Fulton, Jonathan P. Rose, Brian J. Halstead Aug 2022

Are Canned Sardines Or Dry Cat Food More Effective As Bait For Capturing Northwestern Pond Turtles (Actinemys Marmorata) And Red-Eared Sliders (Trachemys Scripta Elegans)?, Alexandria M. Fulton, Jonathan P. Rose, Brian J. Halstead

Western North American Naturalist

During an occupancy study of Northwestern Pond Turtles (Actinemys marmorata) and Red-eared Sliders (Trachemys scripta elegans) in California’s Sacramento Valley in 2018, we tested the relative effectiveness of 2 bait types: sardines packed in soybean oil and Meow Mix® Original Choice dry cat food. We sampled 116 sites with 2 traps each: one baited with sardines and one baited with dry cat food. Sardines were 1.7 (95% confidence interval, 1.2–2.6) times more effective than dry cat food at capturing turtles in our study, and 63% of all captured turtles were caught in traps baited with …

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Archaeological Data Suggest Seventeenth-Century Presence Of Common Snapping Turtle (Chelydra Serpentina) In The Middle Rio Grande, Emily Lena Jones, Laura W. Steele, Cyler Conrad Aug 2022

Archaeological Data Suggest Seventeenth-Century Presence Of Common Snapping Turtle (Chelydra Serpentina) In The Middle Rio Grande, Emily Lena Jones, Laura W. Steele, Cyler Conrad

Western North American Naturalist

The Common Snapping Turtle (Chelydra serpentina) is well established in the Middle Rio Grande today, but some researchers have suggested this population to be of anthropogenic origin. In this paper, we present a C. serpentina specimen recovered during archaeological excavations at the Isleta Pueblo Mission in central New Mexico. The turtle specimen derives from an archaeological context securely dated to the early seventeenth century. The presence of C. serpentina in this context, taken together with the composition of the rest of the Isleta Pueblo Mission archaeofaunal assemblage and the present-day C. serpentina population in the Middle Rio Grande, …

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Synthesis And Anticancer Evaluation Of Novel Pyrazolo[1,5-A]Pyrimidines: Discovery Of A Novel Lead Compound With Selective Activities Against Vps34 And Jak1-Jh2 Pseudokinase, Reuben Dass Aug 2022

Synthesis And Anticancer Evaluation Of Novel Pyrazolo[1,5-A]Pyrimidines: Discovery Of A Novel Lead Compound With Selective Activities Against Vps34 And Jak1-Jh2 Pseudokinase, Reuben Dass

Theses and Dissertations

A library of 25 novel 3,6-disubstituted and 3-substituted pyrazolo[1,5-a]pyrimidines were synthesized using a microwave chemical reactor in 3 steps with a total reaction time of 1 hour. The products were obtained in good to excellent yields (20-93%, ave. = 62%). The synthesis began with the reaction of aryl acetonitriles with dimethylformamide-dimethylacetal (120C, 20 min), followed by treatment of the resulting 2-arylacrylonitrile with H2NNH2 • HBr (120C, 20 min). The intermediate 4-arylpyrazol-5-amine obtained was finally reacted with either 2-aryl-substituted malondialdehydes or 1,1,3,3-tetramethoxypropane (120C, 20 min) to give the final products. The products were either collected directly on a Buchner funnel or …

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Regulation Of T Cell Activation By The Cd5 Co-Receptor And Altered Peptides, Characterization Of Thymidine Kinase-Specific Antibodies, And Integrating Genomics Education In Society, Kiara Vaden Whitley Aug 2022

Regulation Of T Cell Activation By The Cd5 Co-Receptor And Altered Peptides, Characterization Of Thymidine Kinase-Specific Antibodies, And Integrating Genomics Education In Society, Kiara Vaden Whitley

Theses and Dissertations

Helper T cells (Th) are a vital component of the immune system responsible for directing other immune cells to eliminate pathogens and cancer. Specifically, Th cells facilitate B cell and cytotoxic T cell (Tc) activation and recruitment and enhance their function against cancer and infectious diseases. Th cells are a valuable resource for improving Tc responses in cancer treatment and have become a focus of immunotherapeutic research. While it is increasingly clear that helper T cells serve an important role, the details about which entities produce an effective Th cell response remain unclear. CD5 is a T cell co-receptor that …

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Examination Of 14-3-3 Interactors Identifies A Novel Mechanism Of Regulation For The Ubiquitin Binding Kinase Tnk1 That Can Be Targeted To Block Tumor Growth, Christina Marie Egbert Aug 2022

Examination Of 14-3-3 Interactors Identifies A Novel Mechanism Of Regulation For The Ubiquitin Binding Kinase Tnk1 That Can Be Targeted To Block Tumor Growth, Christina Marie Egbert

Theses and Dissertations

Decades of research have begun to identify oncogenic mut-drivers that are responsible for driving a large percentage of cancers. These high frequency mut-drivers have therapeutics in the clinic for patient treatment. However, there is another group of low frequency mut-drivers that fail to rise above the noise of the high frequently drivers. These low frequency drivers represent a group of genes with untapped potential for new targeted therapies. However, identifying these drivers can be difficult. This study focuses on identifying new functional phosphorylations using the phospho-docking protein 14-3-3. The family of 14-3-3 proteins have been linked to many oncogenic pathways …

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A Spatial Long-Term Trend Analysis Of Estimated Chlorophyll-A Concentrations In Utah Lake Using Earth Observation Data, Kaylee Brook Tanner Aug 2022

A Spatial Long-Term Trend Analysis Of Estimated Chlorophyll-A Concentrations In Utah Lake Using Earth Observation Data, Kaylee Brook Tanner

Theses and Dissertations

We analyzed chlorophyll-a (chl-a) concentrations in shallow, turbid Utah Lake using Landsat data from 1984 to 2021. Utah Lake is ~40 km by 21 km, has a surface area of ~390 km2, an average depth of ~3 m, and loses ~50% of inflow to evaporation. This limits spatial mixing, allowing us to evaluate impacts to smaller lake regions. We evaluated long-term trends at the pixel level and for areas related to boundary conditions. We created 17 study areas based on differences in shoreline development and nutrient inflows. We expected impacted areas to exhibit increasing chl-a trends, as population growth and …

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Effects Of Localized Irrigation And Fertilizer On Woody Plant Establishment In Degraded Semi-Arid Environments, Holley M. Lund Aug 2022

Effects Of Localized Irrigation And Fertilizer On Woody Plant Establishment In Degraded Semi-Arid Environments, Holley M. Lund

Theses and Dissertations

Semi-arid native plant communities worldwide are often disturbed either intentionally or incidentally by human activity. In order to restore ecological function after human activities cease, native plant communities need to be restored. Woody plants are important to ecological function for many reasons including reducing erosion and providing food and shelter for wildlife. Unfortunately, woody plant establishment in these areas has proven to be challenging. Direct seeding efforts can be hindered by poor germination and low seedling emergence. To overcome this, seedling transplants are often used in harsh sites. However, transplanted woody seedlings often experience high mortality during the first year, …

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Design And Characterization Of A Miniaturized Spectrometer For Wearable Applications, Tyler Richard Westover Aug 2022

Design And Characterization Of A Miniaturized Spectrometer For Wearable Applications, Tyler Richard Westover

Theses and Dissertations

As individual health monitors continue to become more widely adopted in helping individuals make informed decisions, new technologies need to be developed to obtain more biometric data. Spectroscopy is a well-known tool to gain biological information. Traditionally spectrometers are large and expensive making personal or wearable health monitors difficult. Here we present the development and characterization of a miniaturized short wavelength infrared spectrometer for wearable applications. We present a carbon nanotube parallel hole collimator can effectively select a narrow set of allowed angles of light to be separated by a linear variable filter and detected at a photodiode array making …

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Multiscale Modeling And Analysis Of X-Ray Windows, Microcantilevers, And Bioimpedance Microelectrodes, Kyle Grant Larsen Aug 2022

Multiscale Modeling And Analysis Of X-Ray Windows, Microcantilevers, And Bioimpedance Microelectrodes, Kyle Grant Larsen

Theses and Dissertations

X-ray detector windows must be thin enough to transmit sufficient low-energy x-rays, yet strong enough to withstand up to an atmosphere of differential pressure. Traditional low-energy x-ray windows consist of a support layer and pressure membrane spanning that support. Numerical modeling of several x-ray windows was used to show that both low- and high-energy x-ray transmission can be improved by adding a secondary support structure. Finite element analysis of the x-ray window models showed that the stress from a typical applied load does not exceed the ultimate strength or yield strength of the respective materials. The specific x-ray window models …

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Jack And Phil: Associations Between Exposure To Television Parents, Parental Stress And Efficacy, Jane Elizabeth Shawcroft Aug 2022

Jack And Phil: Associations Between Exposure To Television Parents, Parental Stress And Efficacy, Jane Elizabeth Shawcroft

Theses and Dissertations

Although parents in television are often depicted in negative patterns, little to no research has empirically examined the effect of viewing these depictions of parent efficacy and stress. The purpose of this study is to use experimental methods to assess the effect of viewing authoritative, authoritarian, and stereotypical depictions of parents in television on parental efficacy and parent stress. A sample of 122 parents of adolescents were randomly assigned to one of three condition groups: authoritarian, authoritative, and stereotypical. Each group watches a different clip from a television show, and then reported on their comparison of themselves against the parents …

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Qualitative Proteomic And Genomic Analysis Of Klebsiella Pneumoniae Bacteriophage Kaomega, Emilee Carr Aug 2022

Qualitative Proteomic And Genomic Analysis Of Klebsiella Pneumoniae Bacteriophage Kaomega, Emilee Carr

Undergraduate Honors Theses

Klebsiella pneumoniae is a Gram-negative Enterobacteriaceae that is a common nosocomial pathogen causing pneumonia, infections in the bloodstream, wound infections, and meningitis. It has developed natural resistance to multiple antibiotics, most notably carbapenems which are often seen as the last line of defense against multi-drug resistant pathogens. Bacteriophages are being investigated as a promising alternative treatment to antibiotics in fighting these resistant pathogens. KaOmega, a Klebsiella pneumoniae bacteriophage, was isolated, sequenced, and annotated to characterize and understand its potential for use in a phage therapy. Characterization included Phyre2 analysis to predict putative protein functions based on structural homology, burst size …

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A Machine Learning Approach That Integrates Clinical Data And Ptm Proteomics Identifies A Mechanism Of Ack1 Activation And Stabilization In Cancer, Eranga Roshan Balasooriya Loku Balasooriyage Aug 2022

A Machine Learning Approach That Integrates Clinical Data And Ptm Proteomics Identifies A Mechanism Of Ack1 Activation And Stabilization In Cancer, Eranga Roshan Balasooriya Loku Balasooriyage

Theses and Dissertations

Identification of novel cancer driver mutations is crucial for targeted cancer therapy, yet a difficult task especially for low frequency drivers. To identify cancer driver mutations, we developed a machine learning (ML) model to predict cancer hotspots. Here, we applied the ML program to 32 non-receptor tyrosine kinases (NRTKs) and identified 36 potential cancer driver mutations, with high probability mutations in 10 genes, including ABL1, ABL2, JAK1, JAK3, and ACK1. ACK1 is a member of the poorly understood ACK family of NRTKs that also includes TNK1. Although ACK1 is an established oncogene and high-interest therapeutic target, the exact mechanism of …

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Economic And Hydraulic Simulation Models For Evaluation Of Sediment Management In A Reservoir, Razieh Anari Aug 2022

Economic And Hydraulic Simulation Models For Evaluation Of Sediment Management In A Reservoir, Razieh Anari

Theses and Dissertations

Reservoir sedimentation is a serious problem that threatens the water storage capacities across the world. Extending a dam's life requires adopting a new design and operational paradigm that focuses on managing the reservoir and watershed system to bring sediment inflow and outflow into balance by including reservoir sediment management facilities in dam and reservoir. However, the cost of methods that remove the sediment from reservoirs is usually prohibitive and is a serious factor preventing sustainable sediment management. This thesis considered a case study, Paonia Reservoir in Colorado, to investigate two aspects of reservoir operation, sediment management and economic assessment. The …

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Sequencing The Guts Out Of Covid-19; The Evolution Behind The Covid-19 Pandemic, Madelyn Purnell Aug 2022

Sequencing The Guts Out Of Covid-19; The Evolution Behind The Covid-19 Pandemic, Madelyn Purnell

Undergraduate Honors Theses

The global COVID-19 pandemic has led to an urgent need for scalable methods for clinical diagnostics and tracking of virus variants. In this paper, we attempted a novel method of sequencing using Large Reverse Transcriptase-based cloning (LRTC). Although our methodology ended up not working due to high amount and fast degradation of RNA, we were able to sequence multiple variants of COVID-19 Positive samples from the BYU Student Health Center and 4 sewage samples to check for variant outbreaks in corresponding times. We were able to find several corresponding variants and track the progression of mutation in our local population.

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Mediation In A Science Classroom, David Ray Davis Aug 2022

Mediation In A Science Classroom, David Ray Davis

Theses and Dissertations

Languaging and translanguaging are very important concepts in science classrooms when considering their role as mediational tools for supporting emergent bilingual students' needs. Languaging, including translanguaging, has to do with how people perceive, connect, and understand the activities and utterances around them through verbal and non-verbal communication in any language. This study positions languaging and translanguaging as mediational tools that can be used for supporting the use of science terms and overcoming second language challenges with them. Emergent bilingual students can benefit from the implementation of languaging characteristics that promote classroom discourse spaces where all their repertoire for responding, and …

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The Effects Of Parents' Socialization Goals, Responsiveness, And Psychological Control On Chinese Adolescents' Anxiety, Chunyue Tu Aug 2022

The Effects Of Parents' Socialization Goals, Responsiveness, And Psychological Control On Chinese Adolescents' Anxiety, Chunyue Tu

Theses and Dissertations

This study investigated the relationship of parents' achievement-oriented and self- development goals (for their children) on youth reported anxiety, while taking parents' psychological control and responsiveness into account as possible mediating factors. More specifically, the purpose of this study was to further investigate the direct/indirect effects of (a) parents' reported achievement-oriented goals on youth anxiety via parental psychological control in two types of schools (key school for more academically advanced students and typical school for students with lower academic achievement); and (b) parents' reported self-development goals on youth anxiety via parental psychological control in key and typical schools. The current …

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Introgression Or Incipient Speciation? Using Geometric Morphometrics And Gene Expression To Characterize Mouth Development In Larval June Sucker And Utah Sucker, Peter C. Searle Aug 2022

Introgression Or Incipient Speciation? Using Geometric Morphometrics And Gene Expression To Characterize Mouth Development In Larval June Sucker And Utah Sucker, Peter C. Searle

Theses and Dissertations

Understanding how biodiversity evolves is a major goal in evolutionary developmental biology because changes in developmental processes are tightly linked with evolutionary diversification. Heterochrony--alteration to the rate or timing of development--can significantly alter the appearance of descendant species. Heterochronic shifts in gene expression and associated morphological change may explain the morphological divergence between the threatened June sucker (Chasmistes liorus) and the sympatric Utah sucker (Catostomus ardens) in Utah Lake, UT, USA. June sucker are endemic to Utah Lake and have subterminal mouths adapted for pelagic feeding, while Utah sucker (Catostomus ardens) have ventral mouths adapted for benthic feeding. As larvae, …

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Use Of Seed Coating Technologies To Improve Cercocarpus Ledifolius (Curl-Leaf Mountain Mahogany) Seed Germination And Emergence To Reclaim Mine Lands, Emily M. Nielson Aug 2022

Use Of Seed Coating Technologies To Improve Cercocarpus Ledifolius (Curl-Leaf Mountain Mahogany) Seed Germination And Emergence To Reclaim Mine Lands, Emily M. Nielson

Theses and Dissertations

Globally, mining is vital to human interests, but its practice can cause landscape alteration which may look unnatural or engineered. The reintroduction of native plants to these areas is needed to restore the visual appeal and ecological function back into these altered mine lands. Cercocarpus ledifolius (curl-leaf mountain mahogany) is one desirable native species in the Intermountain West that is prized for its potential to grow on step and rocky hillsides and for the habitat it provides for wildlife. Unfortunately, C. ledifolius does not establish well from seed, which has been attributed to seed dormancy. The first objective of this …

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Estimating Age In Mule Deer: Accuracy And Influence On Reproduction, Morgan S. Hinton Aug 2022

Estimating Age In Mule Deer: Accuracy And Influence On Reproduction, Morgan S. Hinton

Theses and Dissertations

Accurate estimates of parameters and demographic rates of wildlife populations are crucial to management and conservation. One parameter of interest is age because it influences multiple demographic rates and behaviors including reproduction, dispersal, migration, and disease transmission. There are a number of methods used to estimate ages of wildlife. One of the most common methods used for mammals is evaluation of patterns in dental eruption and tooth wear. In the first chapter, we evaluate the accuracy associated with estimates of age from dental eruption and patterns of tooth wear for mule deer (Odocoileus hemionus). In the second chapter, we use …

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Effects Of A High School Yoga Program On Student-Reported Stress, Resilience, And Academic Outcomes, Stephanie Martha Vance Aug 2022

Effects Of A High School Yoga Program On Student-Reported Stress, Resilience, And Academic Outcomes, Stephanie Martha Vance

Theses and Dissertations

High school yoga programs are gaining popularity throughout the United States. The many perceived benefits of such programs among adolescent groups have shown promising outcomes. This mixed-method evaluation of a high school yoga program aims to evaluate the effects of the program on student-reported stress, resilience, and academic outcomes. Program participants include high school students in yoga classes (n = 61) and comparison classes (n = 37), who completed pre- and post-measure surveys along with social validity measures. Overall findings showed a decrease in stress levels among yoga students compared to comparison students, which approached statistical significance, no significant differences …

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Long-Term Soil Fungal Community Recovery After Fire Is Impacted By Climate Change, Spencer Mcgee, Alyssa Tidwell, Erin Riggs, Hannah Veltkamp, Geoffrey Zahn Aug 2022

Long-Term Soil Fungal Community Recovery After Fire Is Impacted By Climate Change, Spencer Mcgee, Alyssa Tidwell, Erin Riggs, Hannah Veltkamp, Geoffrey Zahn

Western North American Naturalist

Though much is known about fungal importance to forest health, there is very little information about factors that impact recovery times of soil fungal communities after a fire. Soil samples were taken from burn sites within one ecotype of temperate coniferous forest in Utah over a 20-year chronosequence. Sites were selected from available historic burns and were similar in plant community structure, elevation, slope, and aspect. Fungal DNA from these samples was compared to soil from paired unburned sites nearby to measure community similarity and estimate soil fungal recovery rates. Differences between paired burned and unburned sites remained fairly stable …

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Understanding The Complexities Of Anemia In Chronic Inflammatory Diseases From Diagnosis To Treatment, Naomi Rae Flindt Aug 2022

Understanding The Complexities Of Anemia In Chronic Inflammatory Diseases From Diagnosis To Treatment, Naomi Rae Flindt

Theses and Dissertations

Iron is an essential nutrient for energy and DNA replication. Its homeostasis is commonly perturbed by chronic inflammatory mechanisms. Chronic inflammation upregulates a cytokine, hepcidin, that degrades the iron export protein ferroportin. Without a way to export iron into the bloodstream iron availability in blood becomes depleted. Iron depletion in the blood stream hinders erythropoiesis and is termed anemia. Herein I investigate and inhibit the mechanism of hepcidin activation. Inhibition of hepcidin activation has released iron from tissues and alleviated anemic conditions in a cancer model. I have laid the foundation to investigate this pathway in a 3D spheroid model. …

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Genomics-Informed Nursing Care: A Survey Of Nicu Nurses' Experience And Perspectives Related To Genomic Sequencing, Rachel I. Anderson Aug 2022

Genomics-Informed Nursing Care: A Survey Of Nicu Nurses' Experience And Perspectives Related To Genomic Sequencing, Rachel I. Anderson

Theses and Dissertations

Background: Genomic sequencing is used in the Neonatal Intensive Care Unit (NICU) to diagnose babies with genetic disorders. Purpose: To explore the experiences and knowledge of nurses working in NICUs related to genomic sequencing. Methods: This was a mixed-methods, cross-sectional descriptive survey of NICU nurses attending a national conference. Quantitative data were analyzed using descriptive statistics. Qualitative data were coded into categories and themes. Results: Of 188 NICU nurses, nearly half reported experience with genomic sequencing. Among nurses with experience, 62.7% rated the amount of discussion they had with families about genomic sequencing as "0". Additionally, 72.7% of participants reported …

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The Effects Of Polymorphisms Of Viral Protein R Of Hiv-1 On The Induction Of Apoptosis In Primary Cells And The Characterization Of Twelve Novel Bacillus Anthracis Bacteriophage, Jacob D. Fairholm Aug 2022

The Effects Of Polymorphisms Of Viral Protein R Of Hiv-1 On The Induction Of Apoptosis In Primary Cells And The Characterization Of Twelve Novel Bacillus Anthracis Bacteriophage, Jacob D. Fairholm

Theses and Dissertations

Viral protein r (Vpr) of Human immunodeficiency virus type 1 (HIV-1) plays an important role in the ability of the virus to infect cells and cause disease. Two polymorphisms to Vpr have been shown to result in differences in disease progression in infected individuals. R36W tends to result in rapid disease progression while R77Q results in long-term non-progression. In order to better understand how these polymorphisms result in these different disease phenotypes, our lab has recently shown that in cell culture, the R36W polymorphism results in increased viral replication and greater induction of cell death. On the other hand, infection …

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A Comprehensive Phylogeny Of Stick And Leaf Insects (Insecta: Phasmatodea) Reveals Widespread Taxonomic Incongruence, Jackson B. Linde Aug 2022

A Comprehensive Phylogeny Of Stick And Leaf Insects (Insecta: Phasmatodea) Reveals Widespread Taxonomic Incongruence, Jackson B. Linde

Theses and Dissertations

Stick and leaf insects (Insecta: Phasmatodea) are a mesodiverse order of insects distributed across the world. These masters of masquerade crypsis are riddled with analogous morphological characters and lack a robust taxonomic framework. It seems that convergent evolution and the re-evolution of complex traits like wings and ocelli is perhaps the rule rather than the exception in stick insects. To investigate the re-acquisition of traits in this unique study system, a robust phylogenetic framework is essential. Our analyses combine traditional Sanger data with a transcriptomic backbone to provide the most corroborated phylogenetic analyses to date. To accomplish this, we employ …

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Elucidating The Relationship Between Self-Reported Disability And Functional Movement In Individuals With Chronic Low Back Pain, Kelsey Ampudia Clark Aug 2022

Elucidating The Relationship Between Self-Reported Disability And Functional Movement In Individuals With Chronic Low Back Pain, Kelsey Ampudia Clark

Theses and Dissertations

INTRODUCTION: Low back pain (LBP) is often exacerbated by movement and, during functional movements, people with LBP tend to inherently modify their posture and movement patterns to avoid aggravating their pain further. Therefore, analysis of spinal movement in people with LBP is necessary and may lead to the identification of movement-based clusters for optimal treatment. PURPOSE: The overall purpose of this study was to investigate how movement patterns in people with chronic LBP relate to their subjective level of pain-related disability. First, we determined which spinal movements best discriminate between people with chronic LBP and asymptomatic controls; second, we ascertained …

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The Discovery Of Novel 14-3-3 Binding Proteins Atg9a And Ptov1 And Their Role In Regulating Cancer Mechanisms, Colten Mitchell Mcewan Aug 2022

The Discovery Of Novel 14-3-3 Binding Proteins Atg9a And Ptov1 And Their Role In Regulating Cancer Mechanisms, Colten Mitchell Mcewan

Theses and Dissertations

14-3-3 proteins are among a family of phospho-binding proteins that are known to regulate many essential cellular mechanisms. By binding to sites of phosphorylation, 14-3-3s are integrated into multiple signaling pathways that govern critical processes, such as apoptosis, cell cycle progression, autophagy, glucose metabolism, and cell motility. These processes are crucial for tumorigenesis and 14-3-3 proteins are known to play a central role in facilitating cancer progression. In this study, my colleagues and I discover two novel 14-3-3 interacting proteins, ATG9A and PTOV1, that are both vital to essential cellular functions and describe various mechanisms that these two proteins regulate. …

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Experimental Design And Construction Of The First Rotor Induced Collision Cell (Ricc) For Studying High Velocity Molecular Impacts, Abraham Lehi De La Cruz Hernandez Aug 2022

Experimental Design And Construction Of The First Rotor Induced Collision Cell (Ricc) For Studying High Velocity Molecular Impacts, Abraham Lehi De La Cruz Hernandez

Theses and Dissertations

The identification and characterization of molecular biomarkers using mass spectrometry on an orbiting or fly-by spacecraft is one of the preferred analytical techniques in the search for life beyond the Earth. However, analysis is complicated by unwanted molecular dissociation occurring when sampled native molecules impact the instrument at high velocity. The mechanisms of chemical changes produced in high velocity impacts have been studied experimentally in some cases; however, there are significant experimental limitations to these techniques. Here I present the design, construction, and testing of a new experimental technique to produce high velocity molecular and microparticle collisions under a controlled …

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Gendered Differences In The Effects Of Adverse Childhood Experiences On Adolescent Substance Use, Emley A. Holcombe Aug 2022

Gendered Differences In The Effects Of Adverse Childhood Experiences On Adolescent Substance Use, Emley A. Holcombe

Theses and Dissertations

Adolescence is a high-risk period for substance use, and the prevalence of adolescent substance use is a public health concern. Contributing factors for adolescent substance use are adverse childhood experiences (ACEs). ACEs are potentially traumatic childhood events that have negative associations with health and risk behaviors. The purpose of this study is to examine how the accumulation, timing, and duration of early ACEs (by age 5) impacts adolescent substance use. In addition, this study examines differences in these relationships by gender. Data from the Fragile Families and Child Wellbeing Study (FFCW) were used for the logistic regression analyses. The results …

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