Digital Commons Network^™

Interactive Effects Of Salinity And Glyphosate On Wetland Soil Microbial Communities, Ryan Mortensen, Madison Brown, Rachel Wood

Library/Life Sciences Undergraduate Poster Competition 2026

Wetland soil microbes play an important role in maintaining ecosystem health by cycling nutrients, breaking down organic matter, and maintaining water quality. Herbicide exposure has been shown to alter the genetic composition and functional potential of soil microbial communities, including shifts in microbial nutrient cycling processes [1].

Two of the most prominent environmental stressors in Utah’s wetlands are excessive salinity and herbicide exposure. Increased salinity can change how herbicides move and persist in water, which may influence their ecological effects [2]. While each stressor has been studied independently, little is known about their combined effects on soil microbial community structure …

In Silico Studies Of Hiv-1 Vpr R77q Mutant’S Structure And Stability, Linnea Mason, Sidney T. Sithole, Bradford K. Berges

Library/Life Sciences Undergraduate Poster Competition 2026

Human immunodeficiency virus type 1 (HIV-1) is a retrovirus that infects CD4+ T cells. Without treatment, infection with HIV-1 usually leads to acquired immunodeficiency syndrome (AIDS), which is characterized as severe immunosuppression (CD4+ count: < 200cells/mm3 of blood). However, some individuals do not advance to AIDS and are known as long-term non-progressors (LTNP). Interestingly, a small viral protein of HIV-1, called viral protein R (Vpr), has been associated with HIV-1 progression. The R77Q mutant has been linked to the LTNP phenotype and increased levels of apoptosis; however, the mechanisms behind it are not yet understood [1]. Previously, our group has found that Vpr was expressed at lower levels in cells infected with R77Q virus compared to the wildtype (WT) virus by western blot [1]. Image quantification of the bands showed an approximate six-fold reduction in protein levels.

Genetic And Morphological Comparison Between Introduced And Native Populations Of Aspidocelis Neomexicanus, Sadie Hale, Jordan Kirk, Arianna Moore, Perry Van Wagoner, Vicente Fernández Lara, Angelina Romero, Dallin Matthews, Álvaro Osuna Jiménez, Reagan Mckee, Randy Klabacka

Library/Life Sciences Undergraduate Poster Competition 2026

The introduction of non-native species to novel ecosystems can have negative impacts on the environment, economy, and human health.

Understanding the processes driving patterns in dispersion, establishment, and expansion of introduced species can illuminate strategies to reduce the occurrence of introduction and mitigate its effects.

The New Mexico Whiptail (Aspidoscelis neomexicanus) is a parthenogenetic (asexually-reproducing) species of lizard in the family Teiidae.

Exploring The Impact Of Redox Perturbations On Optic Tectum Development And Behavior, Kevin Gray, Bailey Calder, Daniel Andersen, Parker Hamblin, Michael Zeyer, Arminda Suli

Library/Life Sciences Undergraduate Poster Competition 2026

The optic tectum (OT), the non-mammalian counterpart of the mammalian superior colliculus (SC), integrates multisensory information and orchestrates behavioral responses such as reflexive movements and attention shifts. It is localized in the midbrain, where anterior-posterior patterning is regulated by transcription factors dependent on proper endogenous H2O2 levels. Recent studies have implicated the OT/SC and early redox imbalance in neurodevelopmental disorders such as autism spectrum disorder (ASD). Given the importance of H2O2 in midbrain development, we are investigating how redox perturbations may lead to atypical OT circuitry development and, subsequently, result in aberrant behavioral phenotypes, similar to those associated with ASD. …

Enhancing Metabolic Fitness Of Car T-Cells By Removing Cd6, Nate Neyman, Alka Guar, Annie Joy-Larson, Collin Mickelson, Scott Weber

Library/Life Sciences Undergraduate Poster Competition 2026

Honorable Mention - Poster Design

CAR T-cell therapy is a highly effective cancer treatment involving engineering the patient’s T-cells to recognize and kill cancerous cells. This therapy has shown great success for blood cancers but has faced many challenges against solid tumors.

Surrounding tumor cells there is a lack of essential nutrients (oxygen, glucose) for T-cells to metabolize efficiency. Additionally, there is a buildup of excess waste products that directly impair T-cell function (1). To overcome these obstacles, scientists are working on developing longer lasting T-cells with improved metabolism to improve efficacy against cancer cells.

The Story Behind The Waves: Effects Of Urbanization And Female Presence On Waving Behavior In Fiddler Crabs, Katelyn Hansen, Blaine Griffen

Library/Life Sciences Undergraduate Poster Competition 2026

Animal communication plays a central role in survival and reproduction, allowing individuals to convey information about their quality, territory, and reproductive statuses. Because signaling behaviors are often energetically costly and are dependent on both social contexts and habitat, they are sensitive to environmental conditions. Previous research has shown that male sand fiddler crabs (Leptuca pugilator) produce two distinct wave types: D-waves (typically directed towards other males) and up-and-down waves (typically directed toward females), and that they also reduce their waving behavior under urban stress. Urbanization introduces stressors such as habitat alteration and increased disturbances that can change the frequency and …

Discovery Of Short Antimicrobial Peptides In A Periplasmic Expression System, Joel Griffitts, Adam Dunn, Caleb Parker, Matthew Steed

Library/Life Sciences Undergraduate Poster Competition 2026

Short Antimicrobial peptides (sAMPs) have the potential to make a significant impact in the ongoing battle against antibiotic-resistant bacteria. In this project, we aim to discover new sAMPs using a novel peptide expression system in E. coli. Using this system, we have successfully identified various sAMPs by testing both rationally designed peptides and randomized peptide libraries.

Derivation And Validation Of Age-Associated Prognostic Gene Signatures Across Breast Cancer Subtypes, John Speers, Adrienne Parsons, Elizabeth Feliciano, Sandra Mcallister, Lindsey Hale

Library/Life Sciences Undergraduate Poster Competition 2026

Relatively little research has been done investigating the effects of linear age on breast-cancer specific mortality . The development of age-associated gene signatures may reveal interesting gene-set patterns with therapeautic potential. We hypothesize that the separation of patients into age categories will yield more predictive gene-signatures than an age-agnostic approach.

Colorful Proteins: Engineering A Palette Of Novel Chromoprotein Variants, Blake Olson, Anna Bowman, Kyler Fullmer, Joel Griffitts

Library/Life Sciences Undergraduate Poster Competition 2026

2nd Place - Poster Design

• Chromoproteins (CP) are naturally occurring proteins originating from corals or other marine invertebrates that exhibit colors determined by their chromophore region.1
• CPs have applications as biosensors, teaching tools, and agar art; therefore, there is a need for a wide variety of CPs.2
• Hypothesis: Editing amino acid residues around the chromophore will change the chromophore’s conformation, leading to a change in color.

Cholesterol‑Containing Membranes Decrease The Helicity Of The Snare Protein Snap‑25, Christopher E. Hunt Jr., Jason T. Carlson, Michael B. Connell, Fatima D. Dagohoy, Mike Sumison, Jonathan Madsen, Chase M. Tingen, Azer E. White, Tanner M. Blocker, Dixon J. Woodbury

Library/Life Sciences Undergraduate Poster Competition 2026

Neurotransmitter release in neurons requires membrane fusion between synaptic vesicles and the presynaptic membrane. Lipids in both membranes merge through the action of SNARE proteins including SNAP-25. Changes in SNAP-25 structure or lipid composition likely modify this process. SNAP-25 has two isoforms, SNAP-25A (25A) and SNAP-25B (25B), the expression patterns of these isoforms vary throughout different brain regions and neuronal developmental stages. In vivo SNAP-25 anchors to the presynaptic membrane via attachment of palmitic acid to at least one of the four cysteines. Here we show mixing SNAP-25 (not palmitoylated) with liposomes alters both protein structure and lipid properties. Using …

C-Fms Expresses In Early Progenitor Cells & Myeloid-Lineage Leukocytes Based On Analyzing Lineage Markers And Mapping On Ly6c X Cd31 Plots In Bone Marrow, Jane Lundgren, Kelly Amsden, Evan Boesl, Victoria Hall, Emily Shakespear, Pam Van Ry, Sandra Hope

Library/Life Sciences Undergraduate Poster Competition 2026

The Mafia mouse model expresses the green fluorescent protein (GFP) in cells that utilize the macrophage-specific c-fms promoter. The c-fms promoter controls expression of receptor for Colony Stimulating Factor 1. We hypothesize that this promotor may be utilized in bone marrow progenitor cells in addition to the mature cell expression already known in macrophage lineage cells. For this study, bone marrow cells were analyzed by flow cytometry for the expression of c-fms, early progenitor markers, and lineage-specific markers. Expression was also mapped on a Ly6CxCD31 plot, which has been used to distinguish cells based on developmental stage and lineage. This …

Cd6-Knockout Car-T Cells Display Enhanced Cytotoxicity Against Lymphoma Cell Line, Annie Larson, Alka Gaur, Nate Neyman, Collin Mickelson, K. Scott Weber

Library/Life Sciences Undergraduate Poster Competition 2026

Chimeric antigen receptor (CAR)-T cells are genetically engineered T cells that target surface antigens on cancer cells, showing remarkable effectiveness in treating blood cancers [1]. However, CAR-T cells are currently not effective in treating solid tumors, as the tumor microenvironment poses physical and metabolic barriers to effective CAR-T cell function. A notable strategy for increasing CAR-T cell cytotoxicity in a tumor microenvironment is knocking out or overexpressing some genes of the T cell.

Music-Based Intervention For Stress And Sleep In Substance Use Recovery, Olivia A. Coleman

Undergraduate Honors Theses

Aim: Sleep difficulties and elevated stress are common among individuals recovering from substance use disorders (SUDs), often persisting long after initial detoxification. Music-based interventions offer a low-risk, nonpharmacological option that may support sleep and stress regulation. This study examined whether a Structured Music Listening Protocol (SMLP) could improve sleep quality and reduce perceived stress within a residential SUD treatment program.

Methods: Fifty eligible patients were enrolled in the Intervention Group (SMLP – Structured Music Listening Protocol) and fifty in the Control Group (Standardized Therapy) from a residential treatment center for SUDs. Both groups received standard therapy from the center. The …

Scarcity Rewritten: Revenue Tracking As A Catalyst For Growth Mindset And Financial Control, Christian M. Pearson

Undergraduate Honors Theses

While revenue tracking is a widely recognized “best practice” for businesses in developed economies, it is far from a universal practice. In Cambodia and other emerging markets, many small business owners do not track revenue or expenses, which may limit their ability to make sound financial decisions and reinforce psychological responses consistent with chronic resource scarcity. This article examines the effects of a business support intervention in which Cambodian business owners participated in an 8-week program designed to help them calculate profits by tracking revenue, variable costs, and fixed costs. Findings from a randomized field experiment show that business owners …

Quantifying Regional Variation Of Lipid Metabolism In The Brain, Martin D. Sorensen

Undergraduate Honors Theses

Apolipoprotein E gene (APOE) and its associated isoforms are the most significant genetic risk factors for Alzheimer’s disease (AD). The common alleles, APOE2/3/4, exhibit a protective/neutral/risk-inducing impact on sporadic AD development respectively. Our lab’s research focuses on APOE modification of the brain proteome and lipidome, with an emphasis on regional regulation and interest in assessing how APOE4 affects regulation differently between distinct regions of the brain. This thesis presents an analysis of cryosectioned brain samples harvested from young APOE knock-in mice. Using metabolic labeling with deuterated water, we measure turnover and dietary sourcing of lipids. We observe significant differences in …

The Evolution Of Science And The Transformation Of Human Understanding: Toward A Generative Framework Of Learning And Reality, Yoshihiko Ariizumi

Spiritual Proficiency

This essay argues that the development of science can be understood not as linear accumulation, but as a sequence of structural transformations in human understanding. Such a view aligns with a generative framework in which knowledge is not passively received or merely constructed, but emerges through dynamic interactions that reorganize cognitive and experiential structures. By situating this framework within the history of science, we can better understand both the nature of scientific progress and its indispensable role in human development.

Learning As Becoming: A Restored Gospel-Based Reinterpretation Of Scientific Discovery And Human Growth, Yoshihiko Ariizumi

Spiritual Proficiency

For many educators of the Church of Jesus Christ of the Latter-day Saints, a persistent dissonance exists between the secular textbooks we utilize and the restored truths we cherish. Traditional science often presents the universe as a closed, material system where learning is merely the acquisition of data. However, as we align our academic pursuits with the light of the Restored Gospel, we discover that scientific inquiry is not independent of spiritual growth. Rather, it is a primary mechanism through which we experience a fundamental shift in our very nature—moving from "knowing" to "becoming."

On The Generality Of Ground, Hannah M. Kunkel

Undergraduate Honors Theses

It is widely held that true grounding claims are general. That is, individual grounding facts are subsumable under general patterns or principles of ground. In this paper, I advocate a novel position in the theory of ground on which particular grounding facts do not generalize to yield patterns of ground. This is not an argument for grounding pluralism, but is analogous to particularist views in metaethics which hold that moral principles are not general, but particular. If true, particularism about ground dissolves a serious challenge to the theory of ground, Louis deRosset's connection problem for non-reductivism. However, rejecting the generality …

Understanding The Revolutionary Mother Through Emotive Expression In The Works Of Gioconda Belli, Brianna J. Stecher

Undergraduate Honors Theses

This thesis examines the struggle to reconcile the roles of the revolutionary mother as perceived in the emotive expression that the Nicaraguan author Gioconda Belli presents in her poetry. In her writings, Belli illustrates how the perceived responsibilities of a revolutionary woman to her country and her children come into conflict with one another. Furthermore, she showcases the emotions that a woman experiences in seeking to eliminate discord between her responsibilities while she finds a balance. Belli’s incorporation of her personal experience battling to balance these roles further strengthens her presentation of the revolutionary woman’s emotional conflict. The myriad of …

Flight Of The Gods: Charting The Terra Incognita Of Belief Through Dragon Literature, Alanna Hess

Undergraduate Honors Theses

“Flight of the Gods” is a fantasy short story that portrays a religious relationship between humans and dragons to explore themes of religious questioning. In doing so, “Flight of the Gods” unites with modern dragon literature by adapting the dragon motif to address real-world issues. Drawing from research on falcons and falconry, the dragons in this short story exhibit a complex relationship with their human counterparts that emphasizes themes of religious doubt and the complexity of belief. The thesis begins with a critical introduction discussing these topics and then presents the short story.

The Mediterranean Diet As A Protective Factor Against Tobacco-Induced Lung Cancer: Insights From The Italian Population, Morgan V. Roundy

Undergraduate Honors Theses

Lung cancer is the second most commonly diagnosed cancer among men and the third among women in Italy, representing a major public health concern. This ecological, cross-sectional study examined and analyzed regional patterns of smoking prevalence, Mediterranean diet adherence, and age-adjusted lung cancer incidence across Italy, stratified by sex, using publicly available regional and macro-regional data and accounting for age structure and air quality. Smoking prevalence and lung cancer incidence were higher among males than females nationwide, although regional lung cancer patterns did not consistently mirror smoking prevalence, particularly among females. High adherence to the Mediterranean diet was low across …

Quantifying Location-Based Variability Of Regional Brain Metabolism Using Microsamples From Apoe Knock-In Mice, Jason G. Wells, Esteban G. Colman, John C. Price

Undergraduate Honors Theses

Apolipoprotein E (ApoE) is an important lipid transporter in the brain. There are three different ApoE variants: ApoE2, ApoE3, and ApoE4. Each of these variants either contribute to or protect against Alzheimer’s disease (AD). The Hippocampus (HC) and the Entorhinal Region (ER) of the brain consistently develop AD pathology first. We hypothesize that ApoE variants affect lipid and protein metabolism in these regions more strongly than in others. Differences in the regional regulation and the ApoE-isoform impacts of these metabolic pathways remain unknown.

We measured brain protein turnover rates in ApoE knock-in mice labeled with deuterated water. Using a laser …

The Art Of Jussi Björling, Conrad L. Osborne

Journal of the Jussi Björling Societies of the USA & UK

Hello, everybody. Thanks to all of you looking in, and special thanks to Janel Lundgren, who extended the invitation to speak, to Walter Rudolph for hosting our event, to Steve Fischman for handling the sound fragments we’ll be hearing, and to my wife, Molly Regan,for all her help getting the fragments out to Steve. I’ve been following the activities of the Society at one degree of separation for many years, and have met or corresponded with several of you along the way, so I know I’m on home ground, among people as devoted as I am to keeping alive an …

Albumin-Binding Domains In Therapeutic Protein Engineering: A Structural And Computational Perspective On Rational Design, Matthew Argyle, Dallin M. Chipman, Anna Claire Woolley, Bradley C. Bundy, Dennis Della Corte

Faculty Publications

Therapeutic proteins face a critical pharmacokinetic challenge: rapid clearance from circulation limits their clinical efficacy. Albumin-binding domains (ABDs) offer an elegant solution by enabling therapeutic proteins to “hitchhike” on serum albumin’s favorable 19-day half-life through FcRn-mediated recycling. Clinical validation through approved therapeutics like ozoralizumab demonstrates the success of this approach, with preclinical studies showing fusion to an ABD extended half-life to 18 days. This review provides an analysis of ABD-fusion protein design, integrating structural biology, computational prediction, and rational engineering principles. We catalog the major classes of albumin-binding modalities, including bacterial three-helix bundle domains, engineered peptides, antibody-derived binders, and alternative …

Front Matter, Vol. 17

Monographs of the Western North American Naturalist

No abstract provided.

End Matter, Vol. 17

Monographs of the Western North American Naturalist

No abstract provided.

Distributed Model Predictive Control-Based Power Management Scheme For Grid-Integrated Microgrids, Sergio Escareno, Sijo Augustine, Liang Sun, Sathishkumar J. Ranade, Olga Lavrava, Enrico Pontelli, John Hedengren

Faculty Publications

Transitioning from traditional electrical grids to smart grids is currently an ongoing process that many nations are striving for due to their access to renewable resources. Energy management is one of the key parameters that decides the performance of such complex systems. Distributed Model Predictive Control (DMPC) is a promising technique that can be used to improve the energy management of grid-connected systems. This paper analyzes a grid-connected inverter system with DMPC that exchanges key operating parameters with the grid to optimize coordinated power sharing between its respective loads. The state-space model for the inverter is derived and verified to …

Molecular Survival Strategies Against Kidney Filtration: Implications For Therapeutic Protein Engineering, William Heaps, Anna Elise Packard, Kristina M. Mccammon, Tyler P. Green, Joseph P. Talley, Bradley C. Bundy, Dennis Della Corte

Faculty Publications

The glomerular filtration barrier poses a significant challenge for circulating proteins, with molecules below ~60–70 kDa facing rapid renal clearance. Endogenous proteins have evolved sophisticated evasion mechanisms including oligomerization, carrier binding, electrostatic repulsion, and FcRn-mediated recycling. Understanding these natural strategies provides blueprints for engineering therapeutic proteins with improved pharmacokinetics. This review examines how endogenous proteins resist filtration, evaluates their application in protein engineering, and discusses clinical translation including established technologies (PEGylation, Fc-fusion) and emerging strategies (albumin-binding domains, glycoengineering). We address critical challenges of balancing half-life extension with tissue penetration, biological activity, and immunogenicity—essential considerations for the rational design of next-generation …

Acoustic Analysis Of Prosodic Speech Pause In Autistic And Neurotypical Adults, Rachel Johnson

Theses and Dissertations

The purpose of this study is to examine prosodic speech pause across two groups: neurotypical and autistic young adults. Conversational speech samples were collected from 11 neurotypical and 11 autistic young adults between the ages of 18 and 26. Speech samples were subsequently transcribed and analyzed using Praat Software. The boundaries of between- and within-utterance pauses were identified, as well as acoustically determining if the pause was filled, silent, or a combination of both. Results found a significant difference in the frequency of pauses as a function of location, pause type, and neurological status. As expected, combination pauses were the …

Precision Acoustofluidics For High-Throughput Mechanobiology In Suspension Cells, Kaichun Yang, Ruoyu Zhong, Ke Li, John Mai, Pengzhan Liu, Ye He, Joseph Rich, Ying Chen, Janna Wang, Zhiteng Ma, Zhiteng Ma, Xianchen Xu, Qian Wu, Tony Jun Huang

Faculty Publications

Mechanomodulation, the process of altering cellular behavior through applied mechanical forces, plays a critical role in physiological processes and has substantial implications for cancer therapy, immunology, and drug development. However, precise and efficient stimulation of nonadherent cells remains a major challenge, limiting the investigation of mechanotransduction pathways and the development of targeted therapeutics. Here, we developed an acoustofluidic platform named Suspension-cell Targeted Response to Excitation via Acoustofluidic Mechanomodulation (STREAM) to enable precise, high-throughput stimulation of suspension cells. STREAM accomplishes this using 101.14-megahertz high-frequency surface acoustic waves to deliver controlled mechanical stimulation at a throughput of 500,000 cells per minute. STREAM …