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Streamlining The Detection Of Human Thyroid Receptor Ligand Interactions With Xl1-Blue Cell-Free Protein Synthesis And Beta-Galactosidase Fusion Protein Biosensors, J. Porter Hunt, Tyler J. Free, Jackelyn Galiardi, Kevin M. Watt, David W. Wood, Bradley Charles Bundy Sep 2023

Streamlining The Detection Of Human Thyroid Receptor Ligand Interactions With Xl1-Blue Cell-Free Protein Synthesis And Beta-Galactosidase Fusion Protein Biosensors, J. Porter Hunt, Tyler J. Free, Jackelyn Galiardi, Kevin M. Watt, David W. Wood, Bradley Charles Bundy

Faculty Publications

Thyroid receptor signaling controls major physiological processes and disrupted signaling can cause severe disorders that negatively impact human life. Consequently, methods to detect thyroid receptor ligands are of great toxicologic and pharmacologic importance. Previously, we reported thyroid receptor ligand detection with cell-free protein synthesis of a chimeric fusion protein composed of the human thyroid receptor beta (hTRβ) receptor activator and a β-lactamase reporter. Here, we report a 60% reduction in sensing cost by reengineering the chimeric fusion protein biosensor to include a reporter system composed of either the full-length beta galactosidase (β-gal), the alpha fragment of β-gal (β-gal-α), or a …

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What's All The Fuss About Pickleball? Motivational Profiles Of Middle Age And Older Adult Recreational Pickleball Players, David C. Barney, Zack E. Beddoes, Keven A. Prusak, Brandon Weekes Sep 2023

What's All The Fuss About Pickleball? Motivational Profiles Of Middle Age And Older Adult Recreational Pickleball Players, David C. Barney, Zack E. Beddoes, Keven A. Prusak, Brandon Weekes

Faculty Publications

As a person becomes older their physical activity options may change or be reduced. One activity that is proving differently among older adults is pickleball. As of 2022 over 3.1 million people in the United States participate in pickleball (USAPA Pickleball, 2022). From the casual observer, many recreational tennis courts have been modified to accommodate the increase of pickleball players. Also, many of these pickleball players are older (40 +). Thus, the purpose of this study was to investigate the motivational profiles of 40 and older adults towards playing pickleball. Generally, it was learned that 40 and older adults participate …

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Improving Behavior In An Alternative High School Summer Program Using Class‑Wide Function‑Related Intervention Teams: A Pilot Study, Paul Caldarella, Erika J. Richards, Leslie Williams, Emily J. Warburton Sep 2023

Improving Behavior In An Alternative High School Summer Program Using Class‑Wide Function‑Related Intervention Teams: A Pilot Study, Paul Caldarella, Erika J. Richards, Leslie Williams, Emily J. Warburton

Faculty Publications

Effective interventions are needed to help alternative high school teachers manage challenging student behaviors. One such intervention, class-wide function-related intervention teams (CWFIT), is a classroom management program based on positive behavior interventions and supports principles. CW-FIT involves teaching appropriate classroom behavioral expectations (social skills), using high behavior-specific praise-to-reprimand ratios, and an interdependent group contingency to provide differential reinforcement of appropriate classroom behavior and eliminate potential reinforcement of problem behavior. In this pilot study, four alternative high school teachers implemented CW-FIT during a summer school program. A series of single subject A-B designs were used over a 3-week period. Results supported …

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Full Issue Sep 2023

Full Issue

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

No abstract provided.

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Dead Sea Scrolls Photos Acquired Sep 2023

Dead Sea Scrolls Photos Acquired

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

A significant addition to the F.A.R.M.S. research library is the recently published two-volume set of photographs of the Dead Sea Scrolls. Patient and skillful work will be required before any conclusions can be drawn about their contents.

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Book Of Mormon Text Reformatted Sep 2023

Book Of Mormon Text Reformatted

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

Donald W. Parry has reformatted the text of the Book of Mormon so that the reader can easily see the hundreds of examples of parallel and repetitive patterns in the Book of Mormon. For instance, 1 Nephi 22:26 has been formatted with indented lines labeled with English letters, and certain words have been underlined to reveal the passage's chiastic structure.

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The Olive Tree And Jacob 5 Sep 2023

The Olive Tree And Jacob 5

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

On Saturday, March 21, F.A.R.M.S. will hold a symposium at which numerous studies will be presented about the masterful allegory of the olive tree in Jacob 5. Over a dozen speakers will report their findings from 9:00 A.M. to 5:00 P.M. in room 205 JRCB (Law School) at Brigham Young University.

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Welch Appointed Editor Of Byu Studies Sep 2023

Welch Appointed Editor Of Byu Studies

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

John W. Welch, founding president and continuing member of the board of directors of F .A.R.M.S., has been appointed editor-in-chief of the 32-year-old BYU Studies.

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Working Groups Formed Sep 2023

Working Groups Formed

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

A working group is being formed under the direction of Warren Aston and John Sorenson to study how ships were built in the 6th century B.C., which may help us understand the construction of Nephi' s ship and its voyage to America. Persons with substantial knowledge of the history, design, construction, or sailing of small craft are invited to participate.

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Working Groups Formed Sep 2023

Working Groups Formed

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

A project is underway to prepare textual and visual resource files to aid artists and media producers in representing Book of Mormon peoples with (Mesoamerican) historical accuracy. Volunteers within a reasonable distance of Provo who have qualifications and a desire to assist (initially probably as library "gofers") are invited to write to F.A.R.M.S. detailing their interest, availability, and relevant background.

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Working Groups Formed Sep 2023

Working Groups Formed

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

Under the auspices of F.A.R.M.S., Marlon Nance (Geology Department, Univ. of California, Davis) is organizing a working group on Geology and Environment in the Book of Mormon.

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Full Issue Sep 2023

Full Issue

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

No abstract provided.

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More On Abraham In Egyptian Papyri Sep 2023

More On Abraham In Egyptian Papyri

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

F.A.R.M.S. has been pleased to receive several comments from interested readers about the article that appeared in our September Newsletter exploring the possible significance of the name Abraham in certain late Egyptian magical papyri. As that article indicated, full publication of this ongoing work is yet to come. As work progresses, up-todate reports will be given.

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Selected Sperry Symposium Papers Now Available Sep 2023

Selected Sperry Symposium Papers Now Available

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

The annual Sperry Symposium was held at BYU on October 26, 1991. Many of the papers presented will be published next spring. In the meantime, four papers are now available separately on the enclosed order form.

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Articles Available Separately Sep 2023

Articles Available Separately

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

The Summer 1990 issue of BYU Studies, a special issue on the Book of Mormon, is now out of print. The new 1992 F.A.R.M.S catalog, however, lists several of its articles individually.

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Farms Publishing Plans For 1992 Sep 2023

Farms Publishing Plans For 1992

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

F.A.R.M.S. has a full and varied schedule of publishing in 1992. Temple and Cosmos: Beyond This Ignorant Present, the twelfth volume in the Collected Works of Hugh Nibley, will appear in early 1992. This volume contains essays, some not previously published, dealing with the temple and other related topics. In the late summer a revised edition of Abraham in Egypt will appear, which will also contain material published in the Improvement Era in the late 1960s and early 1970s.

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Fragments Of Original Manuscript Discovered, Royal Skousen Sep 2023

Fragments Of Original Manuscript Discovered, Royal Skousen

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

For more than three years, Royal Skousen has been studying the original manuscript of the Book of Mormon. His most recent accomplishment, and undoubtedly one of the most significant, was the discovery, conservation, and photography of a collection of a large number of fragments from the original manuscript.

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Symposium Planned For March Sep 2023

Symposium Planned For March

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

On Saturday, December 14, 1991, a group of 18 scholars met to discuss the ancient history, horticulture, philology, and symbolism of the olive tree, in order to shed light on Zenos's allegory in Jacob 5. Progress reports were given on over twenty projects, notes were shared, and issues discussed.

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Touring Mesoamerica Is An Unforgettable Experience Sep 2023

Touring Mesoamerica Is An Unforgettable Experience

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

One F.A.R.M.S. tour to Guatemala and Mexico returned in November. The next is set to go in February.

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A Probabilistic View Of Protein Stability, Conformational Specificity, And Design, Jacob A. Stern, Tyler J. Free, Kimberlee L. Stern, Spencer Gardiner, Nicholas A. Dalley, Bradley Charles Bundy, Joshua L. Price, David Wingate, Dnnis Della Corte Sep 2023

A Probabilistic View Of Protein Stability, Conformational Specificity, And Design, Jacob A. Stern, Tyler J. Free, Kimberlee L. Stern, Spencer Gardiner, Nicholas A. Dalley, Bradley Charles Bundy, Joshua L. Price, David Wingate, Dnnis Della Corte

Faculty Publications

Various approaches have used neural networks as probabilistic models for the design of protein sequences. These "inverse folding" models employ different objective functions, which come with trade-offs that have not been assessed in detail before. This study introduces probabilistic definitions of protein stability and conformational specificity and demonstrates the relationship between these chemical properties and the p(stucture|seq) Boltzmann probability objective. This links the Boltzmann probability objective function to experimentally verifiable outcomes. We propose a novel sequence decoding algorithm, referred to as “BayesDesign”, that leverages Bayes’ Rule to maximize the p(stucture|seq) objective instead of the p(seq|structure) objective common in inverse folding …

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Full Issue Sep 2023

Full Issue

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

No abstract provided.

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Weights And Measures Paper Ready Sep 2023

Weights And Measures Paper Ready

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

We have experienced some delay in getting the Preliminary Report entitled "Weights and Measures in the Time of Mosiah II" completed. Recent publications on ancient Near Eastern measurement systems sent our staff back to do further research to be sure the paper was up to date and comprehensive. The paper is now available. Participants who had previously ordered It will be receiving their copy in the mail soon.

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Regional Delegates Respond Sep 2023

Regional Delegates Respond

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

Over 100 people throughout the world have agreed to serve as regional delegates for the Foundation.

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Press Releases Spread The Word Sep 2023

Press Releases Spread The Word

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

In an effort to make interesting scriptural research available to a larger audience, the Foundation has issued press releases to LDS periodicals. Jeanette Smith, Michele Steed, John Tanner and Jack Welch prepared short abstracts of several papers that were sent to 25 newspapers in August.

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Advisory Board Expanded Sep 2023

Advisory Board Expanded

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

The July 1982 Newsletter announced the creation of an Advisory Board to help F.AR.M.S. achieve Its ambitious goal of publishing a comprehensive Book of Mormon Encyclopedia. Three devoted individuals have recently added their services to that board. Paul R. Cheesman will be the Advisory Coordinator. Truman G. Madsen will be responsible for External Relations, and Noel B. Reynolds will serve as Academic Relations advisor.

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Exhibits And Open House Sep 2023

Exhibits And Open House

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

During August, the Foundation again sponsored informational exhibits at the CES Symposium and Education Week on BYU campus. We appreciate Reed Hyde, Shannon Magleby, Garth Norman, Stephen Ricks, Larry Smith and Janet Twigg who donated many hours of their time staffing the displays. Over 250 people added their names to the newsletter mailing list as a result of the exhibits.

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Meet Our Director Of Promotion Sep 2023

Meet Our Director Of Promotion

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

Thursday, September 8, 1983 was a red letter day for the Foundation. That was the day Susan Roylance came on board. Things may never be the same again. Mrs. Roylance became acquainted with the Foundation three years ago following a fateful meeting with Kirk Magleby in Guatemala.

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New Faces At Farms Sep 2023

New Faces At Farms

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

In a non-profit research organization, people make the difference, and F.A.R.M.S. has some tremendous new people to Introduce:

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Research Corner Sep 2023

Research Corner

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

New ideas keep cropping up. Here are a few of the more striking points that researchers have recently noticed.

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Help Us Build A Library Sep 2023

Help Us Build A Library

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

'What would you think about building a first-rate research collection of scholarly materials about the Book of Mormon?" asks FAR.M.S. President John W. Welch, who adds, "We think it would be a big step forward in facilitating Book of Mormon research." And this dream may not be too far off.

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