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The Role Of Inspiration In Scientific Scholarship And Discovery: Views Of Theistic Scientists, Kari Ann O'Grady Dec 2007

The Role Of Inspiration In Scientific Scholarship And Discovery: Views Of Theistic Scientists, Kari Ann O'Grady

Theses and Dissertations

This qualitative research study examined the ways those who identify themselves as theistic scientists and scholars experience inspiration, as defined as divine guidance or influence, in their scientific scholarship and discovery. It also explored participants' beliefs about how scientists and scholars can seek and prepare to receive inspiration in their work. Open-ended surveys of 450 participants from the behavioral and natural sciences and from a variety of religious backgrounds were analyzed for content themes in the areas of experiences with inspiration, preparing to receive inspiration, and further thoughts on inspiration in science. The themes extracted indicated that these scientists and …

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Registered Dietitian Dress And The Effect Of Dietitian Dress On Perceived Professionalism, Connie Lynn Packer Dec 2007

Registered Dietitian Dress And The Effect Of Dietitian Dress On Perceived Professionalism, Connie Lynn Packer

Theses and Dissertations

People use others' dress to make assumptions, including how they believe the wearer will behave. Observers then adjust their behavior in response to the anticipated behavior of the wearer. Physician or nurse dress affects the degree to which patients perceive the medical professional as confident, experienced, competent, mature, trustworthy, and professional. Dietitian dress has not been studied. Our purpose was to identify 1) the current level of formality of dress of registered dietitians (RD), 2) characteristics of dress codes, 3) the effect of RD dress on patient/client perceptions of professional traits, and 4) the level of formality at which an …

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Solid Phase Crystallization Of Vanadium Dioxide Thin Films And Characterization Through Scanning Electron Microscopy, Felipe Rivera Dec 2007

Solid Phase Crystallization Of Vanadium Dioxide Thin Films And Characterization Through Scanning Electron Microscopy, Felipe Rivera

Theses and Dissertations

Crystalline films of vanadium dioxide were obtained through thermal annealing of amorphous vanadium dioxide thin films sputtered on silicon dioxide. An annealing process was found that yielded polycrystalline vanadium dioxide thin films, semi-continuous thin films, and films of isolated single-crystal particles. Orientation Imaging Microscopy (OIM) was used to characterize and study the phase and the orientation of the vanadium dioxide crystals obtained, as well as to diferentiate them from other vanadium oxide stoichiometries that may have formed during the annealing process. There was no evidence of any other vanadium oxides present in the prepared samples. Indexing of the crystals for …

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Effects Of Endurance Training On The Ampk Response To Exercise., David Gerald Chesser Dec 2007

Effects Of Endurance Training On The Ampk Response To Exercise., David Gerald Chesser

Theses and Dissertations

Activation of AMP-activated protein kinase (AMPK) results in the upregulation of several intracellular systems which help to prepare a cell for a high energy challenge. The magnitude of the AMPK response to a 10 min bout of exercise has been found to decrease in red quadriceps (RQ) following training, while putative AMPK roles seem to be maintained; specifically, the biogenesis of mitochondria and higher levels of hexokinase II and glucose transporter 4 (GLUT4). If the AMPK response to exercise is responsible in part for these adaptations, how can they be maintained if the AMPK response is attenuated? The purpose of …

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A Process-Based Call Assessment: A Comparison Of Input Processing And Program Use Behavior By Activity Type, Kathryn Rimmasch Dec 2007

A Process-Based Call Assessment: A Comparison Of Input Processing And Program Use Behavior By Activity Type, Kathryn Rimmasch

Theses and Dissertations

In an effort to better understand the mental processing connected to different kinds of CALL activities, this study collected data on time subjects spent, as well as buttons subjects clicked while doing 10 different CALL activities accompanying a beginning French text book. In addition, a group of subjects thought out loud as they completed the same activities. These subjects were recorded on video, their thinking out loud was transcribed and the transcriptions were coded according to how they indicated they were dealing with the language input. The frequencies of coded categories were compared to see if there were connections between …

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Constructive Enabling: Applying A Wilderness Skills Intervention To Support The Therapeutic Change Process Of Adolescent Females In Residential Treatment, Brian K. Malcarne Dec 2007

Constructive Enabling: Applying A Wilderness Skills Intervention To Support The Therapeutic Change Process Of Adolescent Females In Residential Treatment, Brian K. Malcarne

Theses and Dissertations

The purpose of this study was to explore the potential benefits of a primitive wilderness skills intervention (POST) on the therapeutic change process of adolescent females enrolled in a residential treatment center. A qualitative data analysis approach was used. A convenience sample of eight female adolescents was selected by therapist referral. The data were analyzed using open, axial, and selective coding. Data analysis was used to assess participants' progress in the therapeutic change. Further analysis revealed a core theme connecting participants' POST experience with feelings of self-empowerment and reflective connections to their individual therapeutic change process. Constructive enabling was the …

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The Effect Of Febrile Temperature On Plasmodium Falciparum, Heidi Sue Porter Dec 2007

The Effect Of Febrile Temperature On Plasmodium Falciparum, Heidi Sue Porter

Theses and Dissertations

Previously it has been shown that cultures of Plasmodium falciparum died following exposure to a febrile temperature of 40°C, as demonstrated by a decrease in parasitemia of the following generation. In the current study, the effect of 40°C treatment on culture media, erythrocytes, and parasite glucose consumption, were ruled out as possible influences on parasite death, demonstrating that 40°C impacted the parasites directly. Metabolic profiling of DNA synthesis, protein synthesis, and glucose utilization during exposure to 40°C clearly indicated that febrile temperatures had direct effect on major metabolic pathways and parasite development, beginning 20-24 hr after erythrocyte invasion. The ring …

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Women's Perceptions Of Parents, Peers, Romantic Partner And God As Predictive Of Symptoms Severity Among Women In Treatment For Eating Disorders At An Inpatient Facility, Samuel B. Tobler Dec 2007

Women's Perceptions Of Parents, Peers, Romantic Partner And God As Predictive Of Symptoms Severity Among Women In Treatment For Eating Disorders At An Inpatient Facility, Samuel B. Tobler

Theses and Dissertations

The present study examined whether perceptions of parents, peers, romantic partners and God were predictive of eating disorder symptom severity among women in treatment for eating disorders. The sample included 417 women (ages 12 to 56 years) at an inpatient treatment facility for eating disorders. Participants completed a battery of assessment measures at intake and discharge. Change scores were also computed on all measures. Measures included indices of eating disorder symptomology, parental relationships, peer relationships, romantic partner relationships, and religious well-being. Multiple regression analysis showed perceptions of peers and romantic partner to be significant predictors in all analyses; however perceptions …

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Existing Practice And Proposed Changes In Cognitive Assessment Of Utah Students Identified As Deaf And Hard Hearing, Leah Voorhies Dec 2007

Existing Practice And Proposed Changes In Cognitive Assessment Of Utah Students Identified As Deaf And Hard Hearing, Leah Voorhies

Theses and Dissertations

This study presented the past, current, and proposed practice of intelligence testing with a unique population, students identified as deaf and hard of hearing (D/HH). As a basis for describing the cognitive ability of Utah's D/HH students and to improve practice guidelines, 61 D/HH students served by Utah Schools for the Deaf and the Blind (USDB) were administered the Universal Nonverbal Intelligence Test (UNIT) standard battery and the Perceptual Reasoning Index (PRI) subtests from the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV). Based on these data, composite score distributions were described and compared with national standardization samples. Participants' WISC-IV PRI …

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Description Of The Trio/Upward Bound Students' Construction Of Vocations Using George Kelly's Rep Test Method, Maraia Sokia Weingarten Dec 2007

Description Of The Trio/Upward Bound Students' Construction Of Vocations Using George Kelly's Rep Test Method, Maraia Sokia Weingarten

Theses and Dissertations

The Information Age is revolutionizing the way we communicate, acquire knowledge, and perform work. Society is shifting from occupations rooted in industrial production to those associated with knowledge and information, requiring the development of new skills for changing occupations and updating old educational methods. Educators need to be aware of economic and social changes and have a vision for how to design career education to respond to those changes. Individuals must also be prepared to learn on their own as careers evolve and change. The training necessary to adapt to the changing career culture needs to be made available to …

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Family Leisure Involvement And Family Functioning In Samoa, Irene Dora Annandale Fotu Dec 2007

Family Leisure Involvement And Family Functioning In Samoa, Irene Dora Annandale Fotu

Theses and Dissertations

The purpose of this study was to (a) examine the relationship between family leisure involvement and aspects of family functioning (adaptability and cohesion) among Samoan families residing on American Samoa, and (b) to compare the Samoan data to a broad sample of American families to provide a cross-cultural comparison. The sample consisted of 340 adult participants. The Family Leisure Activity Profile (FLAP) was used to measure family leisure involvement. FACES II was used to measure family functioning. Regression analyses conducted on the 340 individuals indicated a positive relationship between core family leisure involvement and family cohesion, adaptability, and overall family …

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Energy Efficiency In Cold-Weather High-End Custom Homes, Joseph R. Kearl Dec 2007

Energy Efficiency In Cold-Weather High-End Custom Homes, Joseph R. Kearl

Theses and Dissertations

Nationally, there is increasing interest in energy efficient homes due to growing energy costs and increased awareness. However, many builders haven't yet incorporated energy saving products and practices into homes. Many builders don't have the resources to evaluate available options and prefer to rely on the experiences of other builders. The purpose of this study was to create energy efficiency benchmarks for cold-weather, high-end custom homes and evaluate current building practices. A list of energy-efficient products and practices was created through a review of relevant literature. A group of expert builders was formed into a committee to help determine energy …

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Isaiah's Burden Prophecies As Spirtual Formulas, Justin Brent Top Dec 2007

Isaiah's Burden Prophecies As Spirtual Formulas, Justin Brent Top

Theses and Dissertations

The Book of Mormon makes it clear that Isaiah's message is of great importance to the modern reader. In order to facilitate modern and personal spiritual application of Isaiah's writings, spiritual "formulas" or principles may be discovered or formulated. These formulas are statements of truth based on the prophet's writings that may be applied in multiple situations and time periods. Such formulas of truth offer valuable insighst across time. These formulas may be understood by analyzing the historical setting of the chapter(s) under review, and through critical examination of the text itself. These formulas provide a solid foundation upon which …

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Calcium Dynamics Affecting Egg Production, Skeletal Integrity, And Egg Coloration In Ring-Necked Pheasants (Phasianus Colchicus), Landon R. Jones Dec 2007

Calcium Dynamics Affecting Egg Production, Skeletal Integrity, And Egg Coloration In Ring-Necked Pheasants (Phasianus Colchicus), Landon R. Jones

Theses and Dissertations

These 4 chapters represent manuscripts formatted for submission to journals based on an experiment conducted on Ring-necked Pheasants (Phasianus colchicus). Calcium limits the distribution of this species, which produces 7-15 eggs per clutch. They may renest up to 5 times per breeding season on a diet low in calcium. The first chapter examines egg production in laying hens on 7 different diets from 0.19-4.47% calcium in the absence of calcium loading. Calcium-loaded pheasants store calcium in medullary bone before an experiment and can draw on this surplus during egg production, possibly skewing experimental results. We measured egg production, egg characteristics, …

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Mayanwiki: An Online, Consensus-Based Linguistic Corpus Of The Mayan Hieroglyphs, Robbie A. Haertel Dec 2007

Mayanwiki: An Online, Consensus-Based Linguistic Corpus Of The Mayan Hieroglyphs, Robbie A. Haertel

Theses and Dissertations

The writing system used by the ancient Maya civilization has intrigued researchers and aficionados for centuries. Now that it has mostly been deciphered, the emphasis in the field of Mayan epigraphy has shifted to a study of the system of phonological, morphological, and grammatical rules that once governed the language that the hieroglyphs encode. One of the most important resources for linguistic study of this type is a comprehensive, electronic corpus of texts to investigate phraseology, frequency information, and collocations. Because Mayan linguistic epigraphy is in the early stages, a publicly available, editable corpus would be an invaluable resource in …

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Phylogeography Of The Livebearer Xenophallus Umbratilis (Teleostei: Poeciliidae): Glacial Cycles And Sea Level Change Predict Diversification Of A Freshwater Tropical Fish, Carissa Poole Jones Dec 2007

Phylogeography Of The Livebearer Xenophallus Umbratilis (Teleostei: Poeciliidae): Glacial Cycles And Sea Level Change Predict Diversification Of A Freshwater Tropical Fish, Carissa Poole Jones

Theses and Dissertations

The biogeography of Central America is considered a classical case study in understanding the impact of vicariant events on patterns of biotic dispersal. While many biogeographers have focused on community composition and geographic limits of species at broad scales across Central America, much less work has focused on post-colonization diversification patterns at finer scales. The livebearing freshwater fish Xenophallus umbratilis presents an ideal system for determining the impact of recent earth history events on biodiversity in northern Costa Rica. Here, we test the hypothesis that marine inundation of the San Carlos and Northern Limón basins during the Miocene has caused …

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A Study Of Habitat Variables Associated With Northern Goshawk Nest Site Activity On The Three National Forests In Southern Utah, Keeli Shea Marvel Dec 2007

A Study Of Habitat Variables Associated With Northern Goshawk Nest Site Activity On The Three National Forests In Southern Utah, Keeli Shea Marvel

Theses and Dissertations

The Northern Goshawk has been a species of concern since its decline in the early 1990s, which has been attributed in part to loss of critical breeding and wintering habitat. Nest site selection of goshawks has been correlated with certain specific site characteristics including, but not limited to, forest species composition, forest stand size, diameter of nest tree, percent cover, tree height, site slope, and aspect. The goshawk holds the status of a Management Indicator Species (MIS) on all of the six national forests in Utah. This status requires annual monitoring to track goshawk numbers and to address any activities …

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Pioneers In Twentieth Century Mormon Media: Oral Histories Of Latter-Day Saint Electronic And Public Relations Professionals, Jonice L. Hubbard Dec 2007

Pioneers In Twentieth Century Mormon Media: Oral Histories Of Latter-Day Saint Electronic And Public Relations Professionals, Jonice L. Hubbard

Theses and Dissertations

The project consists of three parts: a summary of the research, a collection of sixteen oral histories of Latter-day Saint Electronic Media and Public Relations professionals who contributed to the development and growth of media in the Church of Jesus Christ of Latter-day Saints, and a one-hour documentary film, Pioneers in Mormon Media, which gives a brief history of the development of modern mass communications and its use by the Church. This qualitative study investigates who has been involved in Church media, what projects have been accomplished and provides some explanation as to why the Church uses media. The oral …

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Beneficial Fungal Interactions Resulting In Accelerated Germination Of Astragalus Utahensis, A Hard-Seeded Legume, Sean D. Eldredge Dec 2007

Beneficial Fungal Interactions Resulting In Accelerated Germination Of Astragalus Utahensis, A Hard-Seeded Legume, Sean D. Eldredge

Theses and Dissertations

Seed germination is pivotal in the life cycle of native plants in a restorative context because initiation of the metabolic processes critical to establishment is key to survival in such a competitive environment. Dormancy characteristics of some native plants including the subject species, Astragalus utahensis, have evolved mechanisms to control germination in order to maintain a seed bank and ensure germination at the right time under optimal conditions. In vitro germination studies confirm beneficial interactions between Alternaria and Aspergillus fungi and Astragalus utahensis seed. Inoculated seed trials (1.0 x 106 spores/mL) exhibited a highly significant difference in percent germination between …

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Sensitivity Of Half-Cell Potential Measurements To Properties Of Concrete Bridge Decks, Thad Marshall Pinkerton Dec 2007

Sensitivity Of Half-Cell Potential Measurements To Properties Of Concrete Bridge Decks, Thad Marshall Pinkerton

Theses and Dissertations

Half-cell potential testing has been recommended as a non-destructive method for assessing the corrosion potential of reinforcing steel in concrete bridge decks. The technique is particularly useful because it can be utilized to evaluate the probability of corrosion before damage is evident at the surface of a bridge deck. The specific objective of this research was to quantify the effects of age, chloride concentration, concrete cover thickness, spatial position, temperature, and presence or condition of epoxy coating on half-cell potential measurements of concrete bridge decks typical of those in Utah. The laboratory testing associated with this research followed a full-factorial …

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An Evaluation Of Compatibility, Effectiveness, Utility, And Implementation Of Plagiarism-Detection Software Operating In The Honor Code Environment At Brigham Young University, George Louis Joeckel Dec 2007

An Evaluation Of Compatibility, Effectiveness, Utility, And Implementation Of Plagiarism-Detection Software Operating In The Honor Code Environment At Brigham Young University, George Louis Joeckel

Theses and Dissertations

Turnitin plagiarism-detection software was operating as a pilot program conducted by the Center for Teaching and Learning in Winter 2007 on the Brigham Young University (BYU) campus. A sample of 6 instructors and 79 student users participated in this evaluation. The evaluation findings show that Turnitin is compatible with the academic honesty environment created by BYU's Honor Code. Turnitin has been effective at detecting intentional and inadvertent plagiarism at BYU. It has also addressed the problem of multiple submissions of the same material. Recommendations are made for promoting Turnitin at the campus and department level. Training tools are proposed for …

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Web Based Resource Management For Multi-Tiered Web Applications, Bryce Daniel Ott Dec 2007

Web Based Resource Management For Multi-Tiered Web Applications, Bryce Daniel Ott

Theses and Dissertations

The currently emerging trend of building more complex web applications to solve increasingly more involved software problems has led to the the need for a more automated and practical means for deploying resources required by these advanced web applications. As web based applications become more complex and involve more developers, greater system redundancy, and a larger number of components, traditional means of resource deployment become painfully inadequate as they fail to scale sufficiently. The purpose of this research is to provide evidence that a more sound and scalable test and deployment process can be employed and that many of the …

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A Model Of The Relationship Of Perceived Mental And Emotional Problems In The Family-Of-Origin On Marital Satisfaction Of Adult Offspring, Benjamin Oviatt Weinheimer Dec 2007

A Model Of The Relationship Of Perceived Mental And Emotional Problems In The Family-Of-Origin On Marital Satisfaction Of Adult Offspring, Benjamin Oviatt Weinheimer

Theses and Dissertations

The effects of perceived mental/emotional problems (psychopathology) in the family-of-origin on adult offspring marital satisfaction was tested in a model considering the mediating variables of parental marital satisfaction, mother-child relationship quality, father-child relationship quality, and resolution of issues from the family-of-origin. The nationally representative sample (n = 802) drawn from the RELATionship Evaluation (RELATE) database included mostly college educated, lower-middle-class individuals in their first marriage. This sample was used to test a structural equation model that results showed fit the data well. Results showed that historical (distal) factors (such as psychopathology in the family-of-origin) explain only a small portion of …

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A Corpus Of Second Language Attrition Data, Derrell R. Smith Dec 2007

A Corpus Of Second Language Attrition Data, Derrell R. Smith

Theses and Dissertations

This report addresses the lack of progress in the field of Second Language Attrition (L2A). Review of L2A history and literature show this to be cause by lack of appropriate data. Five criteria for appropriate data are suggested and a corpus of L2A data (57,000 words, spoken Spanish) which meets the criteria is presented. The history of the corpus is explained in detail, including subject selection, instruments and methods of collection, and markup -- XML was used to annotate the corpus with nineteen categories of speech errors, adapted from Nation's (2001) "Learning Vocabulary in Another Language." An example analysis of …

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Byu Students' Beliefs About Language Learning And Communicative Language Teaching Activities, Sarah C. Bakker Dec 2007

Byu Students' Beliefs About Language Learning And Communicative Language Teaching Activities, Sarah C. Bakker

Theses and Dissertations

Learner beliefs, which contribute to attitude and motivation, may affect language learning. It is therefore valuable to investigate the malleability of learner beliefs, and to determine whether potentially detrimental beliefs can be ameliorated. This study examines how instruction of the principles of Second Language Acquisition (SLA) affects students' beliefs about classroom activities and their beliefs about language learning in general. The 68 first-year German students at Brigham Young University who participated in this study were asked to rate the effectiveness of three activities typical of communicative language teaching: Dialogue activities, Peer Interview activities, and Information-gap activities. They were also asked …

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It's Alive! The Gothic (Dis)Embodiment Of The Logic Of Networks, Anna Katharine Bennion Dec 2007

It's Alive! The Gothic (Dis)Embodiment Of The Logic Of Networks, Anna Katharine Bennion

Theses and Dissertations

My thesis draws connections between today's network society and the workings of gothic literature in the late eighteenth- and early nineteenth-century. Just as our society is formed and affected by the flow of information, the eighteenth-century culture of sensibility was formed by the merging and flow of scientific "technology" (or new scientific discoveries) and societal norms and rules. Gothic literature was born out of this science-society network, and in many ways embodies the ruptures implicit in it. Although gothic literature is not a network in the same sense as informationalism and the culture of sensibility are, gothic literature works according …

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Niche Separation Along Environmental Gradients As A Mechanism To Promote The Coexistence Of Native And Invasive Species, Edmund R. Priddis Dec 2007

Niche Separation Along Environmental Gradients As A Mechanism To Promote The Coexistence Of Native And Invasive Species, Edmund R. Priddis

Theses and Dissertations

Niche separation may be the key to promoting the long-term coexistence of introduced and native species. Physical alterations to the environment (habitat manipulation) or re-introducing native species to former habitats can exploit the maladapted traits of introduced species to create a refuge for native species. No two species have identical niches because evolutionary constraints differ between species with different evolutionary histories. Our objectives were to determine if cold temperatures could promote coexistence between native least chub and introduced western mosquitofish. We used individual scale and population scale experiments to test four hypotheses: 1) colder temperatures would reduce the aggressive behavior …

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Effects Of Water Vapor On The Kinetics Of The Methylperoxy Radical Self-Reaction And Reaction With Hydroperoxy, Alecia Mower Dec 2007

Effects Of Water Vapor On The Kinetics Of The Methylperoxy Radical Self-Reaction And Reaction With Hydroperoxy, Alecia Mower

Theses and Dissertations

The gas phase reactions of CH3O2 + CH3O2, HO2 + HO2, and CH3O2 + HO2 in the presence of water vapor have been studied at temperatures between 263 and 303 K using laser flash photolysis coupled with UV time-resolved absorption detection at 220 nm and 260 nm. Water vapor concentration was quantified using tunable diode laser spectroscopy operating in the mid-IR. The HO2 self-reaction rate constant is significantly enhanced by water vapor, consistent with what others have reported, whereas CH3O2 self-reaction and the cross-reaction (CH3O2 + HO2) rate constants are nearly unaffected. The enhancement in the HO2 self-reaction rate coefficient …

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The Rate And Timing Of Direct Mountain Front Recharge In An Arid Environment, Silver Island Mountains, Utah, Gregory T. Carling Dec 2007

The Rate And Timing Of Direct Mountain Front Recharge In An Arid Environment, Silver Island Mountains, Utah, Gregory T. Carling

Theses and Dissertations

Direct mountain front recharge (MFR), water table recharge at the base of the mountain front, was evaluated on the arid (<250 mm/yr precipitation) Silver Island Mountains by comparing mountain precipitation to groundwater response. Direct MFR contributions were assessed on two catchments, one bedrock (i.e., mountain block) dominated and the other alluvial fan (i.e., mountain front) dominated. Catchment precipitation and shallow groundwater levels at each catchment outlet were measured for a 24 month period beginning October 2005. This time period captured one complete hydrologic cycle (December 2005-February 2007) for which annual and seasonal direct MFR rates were calculated. Annual direct MFR was calculated using a modified version of the water table fluctuation (WTF) method as 0.015-0.016% of precipitation on both catchments, with seasonal variations of 0% in summer up to 0.023% in winter, spring and fall. Seasonal direct MFR contributions are similar on the bedrock and the alluvial fan dominated catchments, with a notable exception during fall 2006 when direct MFR was twice as effective on the bedrock dominated system than on the alluvial fan dominated system (0.022% and 0.011% of precipitation, respectively). Darcy's law calculations show similarly low annual direct MFR contributions (0.013-0.032% of precipitation) as those calculated by the WTF method. Calculated direct MFR is 10% or less than typical calculated combined MFR (near surface recharge and deep underflow from the mountain block) for similar terrains and climates, and is only 3.5% of the combined MFR for the Silver Island Mountains as calculated by the Maxey-Eakin model. However, based on total recharge to the adjacent playa, it is apparent that the Maxey-Eakin model overestimates combined MFR, and the small calculated direct MFR is at least 50% of combined MFR. Despite some uncertainty in the numerical results, several patterns are evident in the data. The data show that direct MFR occurs in response to small rainfall events throughout much of the year, and that snowmelt is not necessary to produce direct MFR. The data also show that direct MFR responds more quickly and flushes through the system faster on the alluvial fan catchment than on the bedrock catchment.

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Neuronal And Molecular Adaptations Of Gaba Neurons In The Ventral Tegmental Area To Chronic Alcohol, Kimberly Hales Dec 2007

Neuronal And Molecular Adaptations Of Gaba Neurons In The Ventral Tegmental Area To Chronic Alcohol, Kimberly Hales

Theses and Dissertations

The purpose of this thesis project was to examine the effects of chronic alcohol on the excitability and molecular adaptation of GABA neurons of the ventral tegmental area (VTA). GABA neurons are of interest with regards to ethanol intoxication, reinforcement, and dependence due to their widespread distribution and connectivity to mesocorticolimbic dopamine (DA) neurons implicated in alcohol reward and addiction. Since we have previously shown adaptation of VTA GABA neuron firing rate to chronic ethanol (Gallegos, Criado et al. 1999) and suppression of gap-junction (GJ) mediated coupling between these neurons by acute ethanol (Stobbs, Ohran et al. 2004), we wanted …

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