Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Brigham Young University

Discipline
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 841 - 870 of 8047

Full-Text Articles in Entire DC Network

Charge Detection Mass Spectrometry Using Printed Circuit Board Arrays For The Analysis Of Microparticles In The Martian Atmosphere, Elaura Luanne Gustafson Sep 2022

Charge Detection Mass Spectrometry Using Printed Circuit Board Arrays For The Analysis Of Microparticles In The Martian Atmosphere, Elaura Luanne Gustafson

Theses and Dissertations

Charge detection mass spectrometry (CDMS) is a single particle technique capable of simultaneously measuring charge and mass-to-charge ratios for individual ions or particles. The linear array CDMS design theoretically has no upper mass limit and is therefore a choice method for the analysis of high mass and heterogeneous samples, such as dust microparticles in the Martian atmosphere. This dissertation describes the development of a novel charge detection mass spectrometer made of printed circuit boards (PCB) for the analysis of dust microparticles in the Martian atmosphere. Development of this device has required investigations in analysis methods and the engineering design of …

Go to article

An Analog For Large-Scale Lacustrine Deposits: 3d Characterization Of A Pleistocene Lake Bonneville Spit, Eli D. Lopez Sep 2022

An Analog For Large-Scale Lacustrine Deposits: 3d Characterization Of A Pleistocene Lake Bonneville Spit, Eli D. Lopez

Theses and Dissertations

Ultra-high-resolution subsurface stratigraphy mapped from 3D ground-penetrating radar (GPR) can provide insights into the fine-scale heterogeneity of reservoirs and other geologic features. Analog models derived from 3D GPR aid in understanding reservoir compartmentalization that may be sub-seismic but still affect fluid flow. We integrate 2D profiles and 3D GPR volumes with measured stratigraphic sections from outcrop exposure to characterize the fine-scale stratigraphy of an ancient Lake Bonneville shoreline deposit (locally, circa 20 ka based on carbon-14 dating) in the Great Basin (northwestern Utah). The heterogeneity of the deposit is expressed as multiple discordant patterns, separated by unconformities that likely were …

Go to article

The Socioeconomic Achievement Gap In The Us Public Schools, Kate Bradley Sep 2022

The Socioeconomic Achievement Gap In The Us Public Schools, Kate Bradley

Ballard Brief

Impoverished children are severely disadvantaged before even reaching adulthood. In public schools, lower-income children are significantly less likely to succeed than their wealthier classmates. Poverty affects a child's brain development, inhibiting their ability to learn and understand. In addition, lower income students go to schools with insufficient funding and resources: quality teachers or the lack thereof increase the inability to provide for these students adequately. The achievement gap affects students by increasing dropout rates. It involves the nation by costing the US nearly $700 billion annually. Even more grave than the financial consequences is the loss of every student-each with …

Go to article

The Future Of Civilization: A Systems Approach, Robert Bedeski, Ph.D. Sep 2022

The Future Of Civilization: A Systems Approach, Robert Bedeski, Ph.D.

Comparative Civilizations Review

Civilization is one of several stages of human evolution and forms a system of interaction. Its past dominance is now challenged by growth of three subsystems — state, economy, and science/technology. These three subsystems have matured through application of rational knowledge. The vertically integrated state now dominates society and demarcated territory. The horizontally integrated global economy and global science/technology society have become worldwide in scope. State domination is reinforced by autonomous global science and international capital. The remaining subsystem of Moral Knowledge occupies present non-material civilization and is characterized by organic knowledge and embracing the unprovable, which includes religion, art, …

Go to article

Air Quality Impacts From Mineral Dust, Fireworks, And Urban Pollution Revealed By Trace Element Chemistry And Strontium Isotopes Ratios In The Wasatch Front, Utah, Usa, Micah J. Marcy Aug 2022

Air Quality Impacts From Mineral Dust, Fireworks, And Urban Pollution Revealed By Trace Element Chemistry And Strontium Isotopes Ratios In The Wasatch Front, Utah, Usa, Micah J. Marcy

Theses and Dissertations

Airborne particulate matter (PM) in urban areas is derived from a combination of natural and anthropogenic sources. To identify PM sources and their effects on air quality, we collected PM using active filter samplers over a two-year period in the urban Wasatch Front, northern Utah, an area affected by multiple pollution sources. Filters from active samplers and other PM samples were analyzed for major and trace element concentrations and 87Sr/86Sr ratios. We identified wind-blown mineral dust from dry lake beds, winter inversions, and fireworks as primary PM sources affecting air quality in the Wasatch Front. Dust contributes Al, Be, Ca, …

Go to article

Still No Crystal Ball: Toward An Application For Broad Evaluation Of Student Understanding, Piper Armstrong Aug 2022

Still No Crystal Ball: Toward An Application For Broad Evaluation Of Student Understanding, Piper Armstrong

Theses and Dissertations

Evaluation of student understanding of learning material is critical to effective teaching. Current computer-aided evaluation tools exist, such as Computer Adaptive Testing (CAT); however, they require expert knowledge to implement and update. We propose a novel task, to create an evaluation tool that can predict student performance (knowledge) based on general performance on test questions without expert curation of the questions or expert understanding of the evaluation tool. We implement two methods for creating such a tool, find both methods lacking, and urge further investigation.

Go to article

Synthesis And Anticancer Evaluation Of Novel Pyrazolo[1,5-A]Pyrimidines: Discovery Of A Novel Lead Compound With Selective Activities Against Vps34 And Jak1-Jh2 Pseudokinase, Reuben Dass Aug 2022

Synthesis And Anticancer Evaluation Of Novel Pyrazolo[1,5-A]Pyrimidines: Discovery Of A Novel Lead Compound With Selective Activities Against Vps34 And Jak1-Jh2 Pseudokinase, Reuben Dass

Theses and Dissertations

A library of 25 novel 3,6-disubstituted and 3-substituted pyrazolo[1,5-a]pyrimidines were synthesized using a microwave chemical reactor in 3 steps with a total reaction time of 1 hour. The products were obtained in good to excellent yields (20-93%, ave. = 62%). The synthesis began with the reaction of aryl acetonitriles with dimethylformamide-dimethylacetal (120C, 20 min), followed by treatment of the resulting 2-arylacrylonitrile with H2NNH2 • HBr (120C, 20 min). The intermediate 4-arylpyrazol-5-amine obtained was finally reacted with either 2-aryl-substituted malondialdehydes or 1,1,3,3-tetramethoxypropane (120C, 20 min) to give the final products. The products were either collected directly on a Buchner funnel or …

Go to article

Yardang Morphometry And Substrate Properties In Ignimbrites Of The Campo Piedra Pomez, Argentina Compared With The Medusae Fossae Formation, Mars, Dylan Stephen Mcdougall Aug 2022

Yardang Morphometry And Substrate Properties In Ignimbrites Of The Campo Piedra Pomez, Argentina Compared With The Medusae Fossae Formation, Mars, Dylan Stephen Mcdougall

Theses and Dissertations

Yardangs are streamlined ridges carved by the action of wind into consolidated yet erodible substrates. The direction of sediment transport is indicated by their elongate shapes and steep sides which redirects most of the sediment transport layer onto adjacent low-lying surfaces, resulting in lower erosion rates on the elevated areas. Despite this simple premise, the rates of erosion and transport as well as the material properties necessary to form yardangs have until now been largely unknown. This study aims to determine how material properties affect yardang dimensions in order to use yardang morphometry to derive the mechanical properties of a …

Go to article

Examination Of 14-3-3 Interactors Identifies A Novel Mechanism Of Regulation For The Ubiquitin Binding Kinase Tnk1 That Can Be Targeted To Block Tumor Growth, Christina Marie Egbert Aug 2022

Examination Of 14-3-3 Interactors Identifies A Novel Mechanism Of Regulation For The Ubiquitin Binding Kinase Tnk1 That Can Be Targeted To Block Tumor Growth, Christina Marie Egbert

Theses and Dissertations

Decades of research have begun to identify oncogenic mut-drivers that are responsible for driving a large percentage of cancers. These high frequency mut-drivers have therapeutics in the clinic for patient treatment. However, there is another group of low frequency mut-drivers that fail to rise above the noise of the high frequently drivers. These low frequency drivers represent a group of genes with untapped potential for new targeted therapies. However, identifying these drivers can be difficult. This study focuses on identifying new functional phosphorylations using the phospho-docking protein 14-3-3. The family of 14-3-3 proteins have been linked to many oncogenic pathways …

Go to article

A Spatial Long-Term Trend Analysis Of Estimated Chlorophyll-A Concentrations In Utah Lake Using Earth Observation Data, Kaylee Brook Tanner Aug 2022

A Spatial Long-Term Trend Analysis Of Estimated Chlorophyll-A Concentrations In Utah Lake Using Earth Observation Data, Kaylee Brook Tanner

Theses and Dissertations

We analyzed chlorophyll-a (chl-a) concentrations in shallow, turbid Utah Lake using Landsat data from 1984 to 2021. Utah Lake is ~40 km by 21 km, has a surface area of ~390 km2, an average depth of ~3 m, and loses ~50% of inflow to evaporation. This limits spatial mixing, allowing us to evaluate impacts to smaller lake regions. We evaluated long-term trends at the pixel level and for areas related to boundary conditions. We created 17 study areas based on differences in shoreline development and nutrient inflows. We expected impacted areas to exhibit increasing chl-a trends, as population growth and …

Go to article

Leveraging Large Language Models Trained On Code For Symbol Binding, Joshua Robinson Aug 2022

Leveraging Large Language Models Trained On Code For Symbol Binding, Joshua Robinson

Theses and Dissertations

While large language models like GPT-3 have achieved impressive results in the zero-, one-, and few-shot settings, they still significantly underperform on some tasks relative to the state of the art (SOTA). For many tasks it would be useful to have answer options explicitly listed out in a multiple choice format, decreasing computational cost and allowing the model to reason about the relative merits of possible answers. We argue that the reason this hasn't helped models like GPT-3 close the gap with the SOTA is that these models struggle with symbol binding - associating each answer option with a symbol …

Go to article

Measuring Nonlinear Thomson Scattering At Arbitrary Emission Angles, Mahonri Romero Carranza Aug 2022

Measuring Nonlinear Thomson Scattering At Arbitrary Emission Angles, Mahonri Romero Carranza

Theses and Dissertations

We use photon-counting to measure nonlinear Thomson scattering from low-density electrons in an intense laser focus. The azimuthal and longitudinal polarization components of the second harmonic are measured across much of the full emission sphere. The data show, for the first time experimentally, emission structure in the ‘Northern’ and ‘Southern’ hemispheres, where the ‘North Pole’ aligns with the direction of laser propagation. To obtain these measurements, we installed an additional power amplifier on our Ti:sapphire laser system at BYU. The upgrade delivers ten times more energy to the laser focus than we had previously. This increase comes partly from the …

Go to article

Distribution And Transportation Of Sand And Potential Sand Source Materials On Titan: Implications For The Geologic History, Benjamin Dean Lake Aug 2022

Distribution And Transportation Of Sand And Potential Sand Source Materials On Titan: Implications For The Geologic History, Benjamin Dean Lake

Theses and Dissertations

Titan is an important planetary body for aeolian research because of the vast equatorial sand seas that span 20% of its surface. Previous studies have determined the general margins of sand and sand seas on Titan, and have speculated about the source of Titan's sand. Little research has been done concerning where sand collects in the sand seas. Additionally, the relationships be-tween material distributions as observed by the Cassini Visual and Infrared Mapping Spectrometer (VIMS) and the history of erosion and transportation of sediments across equatorial latitudes is not fully understood. This work focuses on an in depth evaluation of …

Go to article

Design And Characterization Of A Miniaturized Spectrometer For Wearable Applications, Tyler Richard Westover Aug 2022

Design And Characterization Of A Miniaturized Spectrometer For Wearable Applications, Tyler Richard Westover

Theses and Dissertations

As individual health monitors continue to become more widely adopted in helping individuals make informed decisions, new technologies need to be developed to obtain more biometric data. Spectroscopy is a well-known tool to gain biological information. Traditionally spectrometers are large and expensive making personal or wearable health monitors difficult. Here we present the development and characterization of a miniaturized short wavelength infrared spectrometer for wearable applications. We present a carbon nanotube parallel hole collimator can effectively select a narrow set of allowed angles of light to be separated by a linear variable filter and detected at a photodiode array making …

Go to article

Multiscale Modeling And Analysis Of X-Ray Windows, Microcantilevers, And Bioimpedance Microelectrodes, Kyle Grant Larsen Aug 2022

Multiscale Modeling And Analysis Of X-Ray Windows, Microcantilevers, And Bioimpedance Microelectrodes, Kyle Grant Larsen

Theses and Dissertations

X-ray detector windows must be thin enough to transmit sufficient low-energy x-rays, yet strong enough to withstand up to an atmosphere of differential pressure. Traditional low-energy x-ray windows consist of a support layer and pressure membrane spanning that support. Numerical modeling of several x-ray windows was used to show that both low- and high-energy x-ray transmission can be improved by adding a secondary support structure. Finite element analysis of the x-ray window models showed that the stress from a typical applied load does not exceed the ultimate strength or yield strength of the respective materials. The specific x-ray window models …

Go to article

Successful Impoverished Schools: What Are The Existing Conditions In High Poverty Schools That Have A Higher Than Average Proficiency Rate?, Mitchell Winn Nerdin Aug 2022

Successful Impoverished Schools: What Are The Existing Conditions In High Poverty Schools That Have A Higher Than Average Proficiency Rate?, Mitchell Winn Nerdin

Theses and Dissertations

Proficiency levels in schools often correlate with the poverty levels of schools. However, in 2018 three schools in Utah beat the state average proficiency rate on all three of Utah's end of year summative English language arts, mathematics, and science exams. These high scores provide evidence that schools are not necessarily limited by poverty in helping students succeed academically. By examining the schools that beat the state average on at least one exam, this study describes the conditions that were in play, which contributed to their students' academic achievement. A description is given of the conditions in the schools that …

Go to article

Ion Structure Characterization And Energetics In The Gas Phase Using Fourier Transform Ion Cyclotron Resonance Mass Spectrometry And Ion Mobility Spectrometry, Tina Heravi Aug 2022

Ion Structure Characterization And Energetics In The Gas Phase Using Fourier Transform Ion Cyclotron Resonance Mass Spectrometry And Ion Mobility Spectrometry, Tina Heravi

Theses and Dissertations

In this dissertation, I used Fourier transform ion cyclotron resonance mass spectrometry (FTICR) and ion mobility spectrometry (IMS) to study the structure and energetics of supramolecular complex ions in the gas phase. Using the CRAFTI (cross sectional areas by Fourier transform ion cyclotron resonance) technique developed by Dearden’s lab we observed that complexes with alkali cations capping the portals of cucurbit[5]uril (CB[5]) bind halide anions size-selectively in the gas phase. Our data suggest that Cl– binds inside the CB[5] cavity, Br– binds both inside (with Na+ions capping the portals of CB[5]) and outside (when K+caps CB[5]), and I– binds weakly …

Go to article

Informing Professional Development To Support K-12 Blended Teaching: A Study Of Practices Of Seasoned Blended Teachers And Coaching Experiences Of Emerging Blended Teachers, Michelle Jensen Aug 2022

Informing Professional Development To Support K-12 Blended Teaching: A Study Of Practices Of Seasoned Blended Teachers And Coaching Experiences Of Emerging Blended Teachers, Michelle Jensen

Theses and Dissertations

This dissertation is presented in a journal-ready format and aims to inform professional development designed to support blended teaching. The first is a qualitative study of the practices of secondary educators currently using blended teaching strategies. Thematic analysis of the interviews identified activities teachers use in the online space and how they are connected to in-person activities. Activities aligned with two prior frameworks. Moore's (1989) interaction framework supported classifications of student interactions with content, other learners, and instructors. Kimmons et al.'s (2020) technology use framework supported classifications of student use of online technology in passive, interactive, and creative ways. Participants …

Go to article

Economic And Hydraulic Simulation Models For Evaluation Of Sediment Management In A Reservoir, Razieh Anari Aug 2022

Economic And Hydraulic Simulation Models For Evaluation Of Sediment Management In A Reservoir, Razieh Anari

Theses and Dissertations

Reservoir sedimentation is a serious problem that threatens the water storage capacities across the world. Extending a dam's life requires adopting a new design and operational paradigm that focuses on managing the reservoir and watershed system to bring sediment inflow and outflow into balance by including reservoir sediment management facilities in dam and reservoir. However, the cost of methods that remove the sediment from reservoirs is usually prohibitive and is a serious factor preventing sustainable sediment management. This thesis considered a case study, Paonia Reservoir in Colorado, to investigate two aspects of reservoir operation, sediment management and economic assessment. The …

Go to article

Considerations For And Development Of Sound Level Maps For The M16a4 Rifle, Reese D. Rasband Aug 2022

Considerations For And Development Of Sound Level Maps For The M16a4 Rifle, Reese D. Rasband

Theses and Dissertations

Small firearms can create sound levels exceeding the safe threshold of human hearing with even one shot. Understanding how the sound propagates will lead to better range and military drill design. This thesis describes errors associated with different predictive interpolation models for the M16A4. Before directly discussing potential sources of error, the thesis first seeks to validate the data acquired. This is done through waveform inspection with a focus on shot-to-shot consistency. Finding the standard deviation in level between a 10-shot volley provides a good baseline with which other sources of error can be compared to. For both peak and …

Go to article

Has Covid-19 Affected Patenting In The United States?, Johnny Allen Cope Aug 2022

Has Covid-19 Affected Patenting In The United States?, Johnny Allen Cope

Theses and Dissertations

Scholars have studied how exogenous shocks affect innovation, yet the effects of COVID-19 on one measure of innovative activity, numbers of patent applications, are not well understood. This study looks at what effect disruptions related to COVID-19 have had on numbers of patent applications submitted by inventors in the United States. Using the Patent Examination Research Dataset from the United States Patent and Trademark Office and the Oxford COVID-19 Government Response Tracker, I examine how numbers of patent applications have changed in 2020 and what effect economic disruptions, health disruptions, and nonpharmaceutical interventions related to COVID-19 have had on numbers …

Go to article

A Machine Learning Approach That Integrates Clinical Data And Ptm Proteomics Identifies A Mechanism Of Ack1 Activation And Stabilization In Cancer, Eranga Roshan Balasooriya Loku Balasooriyage Aug 2022

A Machine Learning Approach That Integrates Clinical Data And Ptm Proteomics Identifies A Mechanism Of Ack1 Activation And Stabilization In Cancer, Eranga Roshan Balasooriya Loku Balasooriyage

Theses and Dissertations

Identification of novel cancer driver mutations is crucial for targeted cancer therapy, yet a difficult task especially for low frequency drivers. To identify cancer driver mutations, we developed a machine learning (ML) model to predict cancer hotspots. Here, we applied the ML program to 32 non-receptor tyrosine kinases (NRTKs) and identified 36 potential cancer driver mutations, with high probability mutations in 10 genes, including ABL1, ABL2, JAK1, JAK3, and ACK1. ACK1 is a member of the poorly understood ACK family of NRTKs that also includes TNK1. Although ACK1 is an established oncogene and high-interest therapeutic target, the exact mechanism of …

Go to article

Gradient Conditioning In Deep Neural Networks, Michael Vernon Nelson Aug 2022

Gradient Conditioning In Deep Neural Networks, Michael Vernon Nelson

Theses and Dissertations

When using Stochastic Gradient Descent (SGD) to train Artificial Neural Networks, gradient variance comes from two sources: differences in the weights of the network when each batch gradient is estimated and differences between the input values in each batch. Some architectural traits, like skip-connections and batch-normalization, allow much deeper networks to be trained by reducing each type of variance and improving the conditioning of the network gradient with respect to both the weights and the input. It is still unclear to which degree each property is responsible for these dramatic stability improvements when training deep networks. This thesis summarizes previous …

Go to article

Crossing The Threshold: Factors That Influence The Beliefs Of First Year Teachers Regarding Reform-Based Mathematics Instruction, Quinn H. Braden Aug 2022

Crossing The Threshold: Factors That Influence The Beliefs Of First Year Teachers Regarding Reform-Based Mathematics Instruction, Quinn H. Braden

Theses and Dissertations

Teacher preparation programs invest significant resources to influence the beliefs of preservice teachers, including clinical faculty who mentor preservice teachers during practicum experiences. Despite the work of university personnel to guide preservice teachers' beliefs, their influence wanes once preservice teachers cross the threshold into inservice teaching. New mentors, including mentor teachers, instructional coaches, and administrators take the place of university personnel. This quantitative study examined how the beliefs of 77 novice inservice teachers changed toward reform-based mathematics instruction during their first year of teaching. Of the 77 subjects, 50 were interns and 27 had completed student teaching. Near the end …

Go to article

Understanding The Complexities Of Anemia In Chronic Inflammatory Diseases From Diagnosis To Treatment, Naomi Rae Flindt Aug 2022

Understanding The Complexities Of Anemia In Chronic Inflammatory Diseases From Diagnosis To Treatment, Naomi Rae Flindt

Theses and Dissertations

Iron is an essential nutrient for energy and DNA replication. Its homeostasis is commonly perturbed by chronic inflammatory mechanisms. Chronic inflammation upregulates a cytokine, hepcidin, that degrades the iron export protein ferroportin. Without a way to export iron into the bloodstream iron availability in blood becomes depleted. Iron depletion in the blood stream hinders erythropoiesis and is termed anemia. Herein I investigate and inhibit the mechanism of hepcidin activation. Inhibition of hepcidin activation has released iron from tissues and alleviated anemic conditions in a cancer model. I have laid the foundation to investigate this pathway in a 3D spheroid model. …

Go to article

Mirror Symmetry For Some Non-Abelian Groups, Kyle John Niendorf Aug 2022

Mirror Symmetry For Some Non-Abelian Groups, Kyle John Niendorf

Theses and Dissertations

The goal of this thesis is to investigate a conjecture about Mirror Symmetry for Landau Ginzburg (LG) models with non-abelian gauge groups. The conjecture predicts that the LG A-model for a polynomial-group pair $(W,G)$ is equivalent to the LG B-model for the dual pair $(W^*, G^*)$. In particular, the A-model and B-model include the construction of a Frobenius algebra. The LG mirror symmetry conjecture predicts that the A-model Frobenius algebra for $(W,G)$ will be isomorphic to the B-model Frobenius algebra for the dual pair $(W^*,G^*)$. Part of the conjecture includes a rule describing how to construct the dual pair. Until …

Go to article

Student-Created Learning Objects For Mathematics Renewable Assignments: The Potential Value They Bring To The Broader Community, Webster Wong Aug 2022

Student-Created Learning Objects For Mathematics Renewable Assignments: The Potential Value They Bring To The Broader Community, Webster Wong

Theses and Dissertations

Having students create Learning Objects (LOs) through renewable assignments has proved more helpful to the student creators compared to disposable assignments in some aspects. Additionally, some researchers have presented evidence where the student-created LOs could benefit the users of the LOs more than traditional learning resources. In this study, I examined a collection of LOs created by college students in the subject of mathematics to understand the nature of the value that a student-created LO could bring to other learners. By extending a framework for non-disposable assignments (Seraphin et al., 2019), I evaluated 3 components that affect the value of …

Go to article

High-Velocity Impact Dissociation Of Molecular Species In Spacecraft-Based Mass Spectrometers, Brandon M. Turner Aug 2022

High-Velocity Impact Dissociation Of Molecular Species In Spacecraft-Based Mass Spectrometers, Brandon M. Turner

Theses and Dissertations

Mass spectrometers have proven to be vital to understanding the Solar System and the planets within it. Spacecraft containing mass spectrometers have been sent to numerous remote places and have determined important information about the atmospheric composition of Venus, Earth, Mars, Jupiter, and Saturn, along with other celestial bodies. Such results have shown a variety of small neutral molecules, such as CH4 NH3, H2O, CO2, and CO, neutral radicals such as atomic O, H, and N, and a host of small ions, such as H+, N+, and NH4+. Closed ion source inlets, which allow for the detection of these small …

Go to article

The Discovery Of Novel 14-3-3 Binding Proteins Atg9a And Ptov1 And Their Role In Regulating Cancer Mechanisms, Colten Mitchell Mcewan Aug 2022

The Discovery Of Novel 14-3-3 Binding Proteins Atg9a And Ptov1 And Their Role In Regulating Cancer Mechanisms, Colten Mitchell Mcewan

Theses and Dissertations

14-3-3 proteins are among a family of phospho-binding proteins that are known to regulate many essential cellular mechanisms. By binding to sites of phosphorylation, 14-3-3s are integrated into multiple signaling pathways that govern critical processes, such as apoptosis, cell cycle progression, autophagy, glucose metabolism, and cell motility. These processes are crucial for tumorigenesis and 14-3-3 proteins are known to play a central role in facilitating cancer progression. In this study, my colleagues and I discover two novel 14-3-3 interacting proteins, ATG9A and PTOV1, that are both vital to essential cellular functions and describe various mechanisms that these two proteins regulate. …

Go to article

Experimental Design And Construction Of The First Rotor Induced Collision Cell (Ricc) For Studying High Velocity Molecular Impacts, Abraham Lehi De La Cruz Hernandez Aug 2022

Experimental Design And Construction Of The First Rotor Induced Collision Cell (Ricc) For Studying High Velocity Molecular Impacts, Abraham Lehi De La Cruz Hernandez

Theses and Dissertations

The identification and characterization of molecular biomarkers using mass spectrometry on an orbiting or fly-by spacecraft is one of the preferred analytical techniques in the search for life beyond the Earth. However, analysis is complicated by unwanted molecular dissociation occurring when sampled native molecules impact the instrument at high velocity. The mechanisms of chemical changes produced in high velocity impacts have been studied experimentally in some cases; however, there are significant experimental limitations to these techniques. Here I present the design, construction, and testing of a new experimental technique to produce high velocity molecular and microparticle collisions under a controlled …

Go to article

First Prev Next Last