Digital Commons Network^™

Role Of The Cytosolic Chaperonin Cct In The Folding Of Novel Substrates, Theresa M. Smith

Theses and Dissertations

All cells depend on properly folded proteins for survival and function. Misfolding of proteins results in loss of critical functions and may trigger the misfolding of other nearby proteins leading to toxic aggregation. While many proteins can fold on their own, others with complicated domain structures require assistance from protein folding machines called chaperones. The most complex and highly specialized of all chaperones is the eukaryotic chaperonin complex CCT which is necessary for the folding of a wide variety of essential proteins. These include the cytoskeletal proteins actin and tubulin as well as the Gβ subunit of the G protein …

Hierarchical Joint Entity Recognition And Relation Extraction Of Contextual Entities In Family History Records, Daniel Segrera

Theses and Dissertations

Entity extraction is an important step in document understanding. Higher accuracy entity extraction on fine-grained entities can be achieved by combining the utility of Named Entity Recognition (NER) and Relation Extraction (RE) models. In this paper, a cascading model is proposed that implements NER and Relation extraction. This model utilizes relations between entities to infer context-dependent fine-grain named entities in text corpora. The RE module runs independent of the NER module, which reduces error accumulation from sequential steps. This process improves on the fine-grained NER F1-score of existing state-of-the-art from .4753 to .8563 on our data, albeit on a strictly …

Full Issue

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

No abstract provided.

“Let Us Be Strong”: Nephi’S Courage In The Context Of Ancient Near Eastern Military Exhortations, David E. Bokovoy

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

The ancient Near East often witnessed the rise and fall of powerful nations, a fact of life reflected in the literary and cultural traditions of the time. Given the constant specter of war, military leaders frequently needed to exhort their people to extraordinary levels of bravery. Literary evidence shows that the phrase to “be strong” was commonly used in a military sense. The Book of Mormon, with its roots in the ancient Near East, also reflects that usage.

Joseph Smith Right On Target, New Book Shows

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

In his writings over the years, Hugh Nibley has often pointed out “hits” and “bull’s-eyes” in the Book of Mormon—details about the ancient world that were unknown until recent times but that Joseph Smith got right anyway. Serious Book of Mormon research took shape in the early 1900s but has accelerated in recent decades, establishing an entire field of scholarly endeavor and yielding many clues to the book’s ancient origins.

Heat Set Creases In Polyethylene Terephthalate (Pet) Sheets To Enable Origami-Based Applications, Brandon Sargent, Nathan Brown, Brian D. Jensen, Spencer P. Magleby, William G. Pitt, Larry L. Howell

Faculty Publications

Polyethylene terephthalate (PET) sheets show promise for application in origami-based engineering design. Origami-based engineering provides advantages that are not readily available in traditional engineering design methods. Several processing methods were examined to identify trends and determine the effect of processing of PET sheets on the crease properties of origami mechanisms in PET. Various annealing times, temperatures, and cooling rates were evaluated and data collected for over 1000 samples. It was determined that annealing temperature plays the largest role in crease response. An increase in the crystallinity of a PET sheet while in the folded state likely increases the force response …

An Origami-Based Medical Support System To Mitigate Flexible Shaft Buckling, Brandon Sargent, Jared Butler, Kendall Seymour, David Bailey, Brian D. Jensen, Spencer P. Magleby, Larry L. Howell

Faculty Publications

This paper presents the development of an origami-inspired support system (the OriGuide) that enables the insertion of flexible instruments using medical robots. Varying parameters of a triangulated cylindrical origami pattern were combined to create an effective highly-compressible anti-buckling system that maintains a constant inner diameter for supporting an instrument and a constant outer diameter throughout actuation. The proposed origami pattern is composed of two repeated patterns: a bistable pattern to create support points to mitigate flexible shaft buckling and a monostable pattern to enable axial extension and compression of the support system. The origami-based portion of the device is combined …

Developable Mechanisms On Right Conical Surfaces, Lance P. Hyatt, Spencer P. Magleby, Larry L. Howell

Faculty Publications

An approach for designing developable mechanisms on a conical surface is presented. By aligning the joint axes of spherical mechanisms to the ruling lines, the links can be created in a way that the mechanism conforms to a conical surface. Terminology is defined for mechanisms mapped onto a right cone. Models are developed to describe the motion of the mechanism with respect to the apex of the cone, and connections are made to cylindrical developable mechanisms using projected angles. The Loop Sum Method is presented as an approach to determine the geometry of the cone to which a given spherical …

Deployable Convex Generalized Cylindrical Surfaces Using Torsional Joints, Todd G. Nelson, Jared T. Burton, Curtis G. Nelson, Luis M. Baldelomar Pinto, Zhicheng Deng, Larry L. Howell

Faculty Publications

The ability to deploy a planar surface to a desired convex profile with a simple actuation can enhance foldable or morphing airfoils, deployable antennae and reflectors, and other applications where a specific profile geometry is desired from a planar sheet. A model using a system of rigid links joined by torsional springs of tailorable stiffness is employed to create an approximate curved surface when two opposing tip loads are applied. A system of equations describing the shape of the surface during deployment is developed. The physical implementation of the model uses compliant torsion bars as the torsion springs. A multidimensional …

Rigidly Foldable Thick Origami Using Designed-Offset Linkages, Robert J. Lang, Nathan Brown, Brian Ignaut, Spencer P. Magleby, Larry L. Howell

Faculty Publications

We present new families of thick origami mechanisms that achieve rigid foldability and parallel stacking of panels in the flat-folded state using linkages for some or all of the hinges between panels. A degree-four vertex results in a multi-loop eight-bar spatial mechanism that can be analyzed as separate linkages. The individual linkages are designed so that they introduce offsets perpendicular to the panels that are mutually compatible around each vertex. This family of mechanisms offers the unique combination of a planar unfolded state, parallel-stacked panels in the flat folded state, and kinematic single-degree-of-freedom motion from the flat- unfolded to the …

On The Modeling Of A Contact-Aided Cross-Axis Flexural Pivot, Pietro Bilancia, Giovanni Berselli, Spencer P. Magleby, Larry L. Howell

Faculty Publications

This paper reports the study of a planar Cross-Axis Flexural Pivot (CAFP) comprising an additional contact pair. The proposed device turns useful for applications requiring a revolute joint that behaves differently when deflecting clockwise/anti-clockwise. The presence of the contact pair reduces the free length of one flexures, resulting in a considerable increment of the overall joint stiffness. The pivot behaviour is investigated, for different load cases, via the ChainedBeam-Constraint Model (CBCM), namely an accurate method to be applied in large deflection problems. A framework comprising Matlab and ANSYS is developed for testing the CAFP performances in terms of rotational stiffness, …

Kinetostatic And Dynamic Modeling Of Flexure-Based Compliant Mechanisms: A Survey, Mingxiang Ling, Larry L. Howell, Junyi Cao, Guimin Chen

Faculty Publications

Flexure-based compliant mechanisms are becoming increasingly promising in precision engineering, robotics and other applications due to the excellent advantages of no friction, no backlash, no wear, and minimal requirement of assembly. Because compliant mechanisms have inherent coupling of kinematic- mechanical behaviors with large deflections and/or complex serial-parallel configurations, the kinetostatic and dynamic analyses are challenging in comparison to their rigid-body counterparts. To address these challenges, a variety of techniques have been reported in a growing stream of publications. This paper surveys and compares the conceptual ideas, key advances, applicable scopes and open problems of the state-of-the-art kinetostatic and dynamic modeling …

Design Of Regular 1d, 2d, And 3d Linkage-Based Tessellations, Alden D. Yellowhorse, Nathan Brown, Larry L. Howell

Faculty Publications

Linkage origami is one effective approach for addressing stiffness and accommodating panels of finite size in origami models and tessellations. However, successfully implementing linkage origami in tessellations can be challenging. In this work, multiple theorems are presented that provide criteria for designing origami units or cells that can be assembled into arbitrarily large tessellations. The application of these theorems is demonstrated through examples of tessellations in two and three dimensions.

Analysis Of The Rigid Motion Of A Conical Developable Mechanism, Mckell Woodland, Michelle Hsiung, Erin L. Matheson, C Alex Safsten, Jacob Greenwood, Denise M. Halverson, Larry L. Howell

Faculty Publications

We demonstrate analytically that it is possible to construct a developable mechanism on a cone that has rigid motion. We solve for the paths of rigid motion and analyze the properties of this motion. In particular, we provide an analytical method for predicting the behavior of the mechanism with respect to the conical surface. Moreover, we observe that the conical developable mechanisms specified in this paper have motion paths that necessarily contain bifurcation points which lead to an unbounded array of motion paths in the parameterization plane.

Limits Of Extramobile And Intramobile Motion Of Cylindrical Developable Mechanisms, Jared Butler, Larry L. Howell, Spencer P. Magleby, Jacob Greenwood

Faculty Publications

Mechanisms that can both deploy and provide motions to perform desired tasks offer a multifunctional advantage over traditional mechanisms. Developable mechanisms (DMs) are devices capable of conforming to a predetermined developable surface and deploying from that surface to achieve specific motions. This paper builds on the previously identified behaviors of extramobility and intramobility by introducing the terminology of extramobile and intramobile motion, which define the motion of developable mechanisms while interior and exterior to a developable surface. The limits of motion are identified using defined conditions. It is shown that the more difficult of these conditions to kinematically predict may …

Designing A Makerspace, Mackenzie Dinsmoor

Instructional Psychology and Technology Graduate Student Projects

The purpose of this project was to design a makerspace in the McKay School of Education here at Brigham Young University. This project is for pre-service teachers and faculty in the Teacher Education Department primarily in the Elementary Education program.

The purpose of a makerspace is to provide students with the materials and experiences to iteratively design and create. It’s a place for hands-on learning with all the tools for creativity. Makerspaces provide creative ways to encourage students to design, experiment, build and invent as they deeply engage in science, engineering and tinkering. A makerspace is not solely a science …

Conceptualizing Stable States In Origami-Based Devices Using An Energy Visualization Approach, Jacob Greenwood, Larry L. Howell, Alex Avila, Spencer P. Magleby

Faculty Publications

In many origami-based applications, a device needs to be maintained in one or more fold states. The origami stability integration method (OSIM) presented in this paper pro- vides an approach for graphically combining various techniques to achieve stability. Existing stability techniques are also categorized into four groups based on whether they are intrinsic or extrinsic to the origami pattern and whether they exhibit gradual or non-gradual energy storage behaviors. These categorizations can help designers select appropriate techniques for their applications. The paper also contains de- sign considerations and resources for achieving stability. Finally, two case studies are presented that use …

Thinking Ahead: The Advent Of New Paradigms In International Relations Theory: “Truth Unfolds In Time Through A Communal Process.” - Carroll Quigley, Vlad Alalykin-Izvekov Phd

Comparative Civilizations Review

International Relations Theory is a branch of Political Science that studies International Relations from a theoretical perspective. Historically, it was dominated by two paradigms — Realism and Liberalism. Recently, though, among other theories and perspectives an influential Civilizational Paradigm has emerged. The paper contains analysis of the roots, significance, as well as discontents of those schools of thought. Looking into the future, the author of this paper proposes the Integralistic Paradigm in International Relations Theory.

The Soul Of Russia And The Soul Of Ukraine, David Wilkinson

Comparative Civilizations Review

This essay addresses the issue of two contemporary state identities — that of Russia and that of Ukraine.

Book Review: Duane W Roller. Eratosthenes’ Geography: Fragments Collected And Translated, With Commentary And Additional Material, Tseggai Isaac

Comparative Civilizations Review

Duane W. Roller brought back to life the enigmatic and flamboyant Eratosthenes by capturing the rich details of Eratosthenes’ intellectual background, his personal life, Eratosthenes’ Geographika; and how Eratosthenes was received by contemporary and nascent critics in later years and decades. Eratosthenes was practical and controversial in the sense that he seemed to use unorthodox methodology of practical observation combined with creative and inventive scientific and mathematical intricacies to explain, define, and analyze his findings. He was flamboyant and fertile in his discoveries and the breadth of his creative imaginations of unparalleled perspicuity. Roller observed:

The discipline of geography …

What Constitutes Evidence For An Historical Explanation?, Kenneth Feigenbaum

Comparative Civilizations Review

What constitutes evidence for an historical explanation? What constitutes evidence for the explanations of the falls and rises of civilization? Better, what constitutes evidence for the best explanation of this phenomenon?

The purpose of this article is to acquaint the readers of the Comparative Civilizations Review with the work of a philosopher of history, Raymond Martin. In particular, I will present his approach on what constitutes how a decision should be made as to which explanation of an historical event is superior to another and why this is so.

Alegaatr The Bandit, Ethan Pedersen

Theses and Dissertations

One design strategy for developing intelligent agents is to create N distinct behaviors. At each time step during task execution, the agent, or bandit, chooses which of the N behaviors to use. Traditional bandit algorithms often (1) assume the environment is stationary, (2) focus on asymptotic performance, and (3) do not incorporate external information available to them. Each of these simplifications limits these algorithms such that they often cannot be used successfully in practice. In this paper, we propose a new algorithm, called AlegAATr, as a step toward overcoming these deficiencies. AlegAATr utilizes a technique called Assumption-Alignment Tracking (AAT), proposed …

Lists Of Selected Full-Text Databases By Subscription In East Asian Studies, Dongyun Ni, Michiko Ito, Ellie Kim, Anlin Yang

Journal of East Asian Libraries

No abstract provided.

Introduction To A Universal Performance Improvement Method (Chigen-Iku), Yoshihiko Ariizumi

Learning, Teaching, & Researching Optimization

This brief article introduces a universal performance improvement method called Chigen-iku, which has been developed carefully and extensively over more than 25 years through more than 100 individual and group projects based on the principles that were selected through my doctorial study in the field of Instructional Psychology and Technology.

Developing Methods For Measuring In Vivo Lipid Metabolism, Russell L. Denton

Theses and Dissertations

Lipid metabolism is critically important to the normal function of individual cells and for signaling between tissues of the human body. There is a great need to quantify changes in lipid metabolism because of its implications in both normal healthy conditions and during disease development. In our first study, we developed a liquid chromatography mass spectrometry based workflow to assess in vivo metabolism of murine brain lipids. This involved sample preparation, data acquisition, and analysis software development and improvements. Regarding sample preparation, we maintained the mice at 5% body water for the duration of the experiment. As mouse metabolism proceeds, …

Turbulent Mixing Simulation Using The Hierarchical Parcel-Swapping (Hips) Model, Tommy Starick, Masoomeh Behrang, David O. Lignell, Heiko Schmidt, Alan R. Kerstein

Faculty Publications

Turbulent mixing is an omnipresent phenomenon that permanently affects our everyday life. Mixing processes also
plays an important role in many industrial applications. The full resolution of all relevant flow scales often poses a major challenge to the numerical simulation and requires a modeling of the small-scale effects. In transported Probability Density Function (PDF) methods, the simplified modeling of the molecular mixing is a known weak point. At this place, the Hierarchical Parcel-Swapping (HiPS) model developed by A.R. Kerstein [J. Stat. Phys. 153, 142-161 (2013)] represents a computationally efficient and novel turbulent mixing model. HiPS simulates the effects of turbulence …

Characterization Of Telsam Chaperone Linker To Improve Crystallization Resolution And Structural Elucidation Of The Hydrogenase Maturase Complex, Parag Laljibhai Gajjar

Theses and Dissertations

TELSAM crystallization can be a revolutionary tool for the facile crystallization of proteins. TELSAM can increase the rate of crystallization and form crystals at low protein concentrations without direct contact between TELSAM polymers and, in some cases, with very minimal crystal contacts overall. To further understand and characterize TELSAM crystallization, we sought to understand the requirements for the composition of the linker confirmation between TELSAM and the fused target protein. We evaluated four linkers, AlaAla, AlaVal, ThrVal, and ThrThr, between 1TEL and the human CMG2 vWa domain. We compared the number of successful crystallization conditions, the number of crystals, the …

Territorial Intrusion By Resident Male Wilson's Warblers: Breeding Stages Of The Intruders And Distances They Travel, William M. Gilbert

Western North American Naturalist

It now is generally recognized that genetic monogamy is the exception in birds, and that extrapair paternity in territorial species requires that one or the other sex involved in such an extrapair mating travel off its own territory to obtain an extrapair copulation. However, which sex or sexes travel off their home territories, the distances they might travel to obtain extrapair copulations, and the breeding stages during which they might make such off-territory forays are poorly understood for most species. I explored these issues in Wilson’s Warblers (Cardellina pusilla) in central, inner-coastal California. Male Wilson’s Warblers frequently intruded …

Origami-Based Design Of Conceal-And-Reveal Systems, Bryce P. Defigueiredo, Kyler A. Tolman, Spencer P. Magleby, Nathan A. Pehrson, Erica Crampton, Larry L. Howell

Faculty Publications

This work introduces a type of motion termed “conceal-and-reveal” which is characterized by a state that protects a payload, a state that exposes the payload, and coupled motions between these two states. As techniques for thick, rigid origami-based engineering designs are being developed, origami is becoming increasingly more

attractive as inspiration for complex systems. This paper proposes a process for designing origami-based conceal- and-reveal systems, which can be generalized to design similar thick, rigid origami-based systems. The process

is demonstrated through the development of three conceal-and-reveal systems that present a luxury product to the consumer. The three designs also confirm …

Kinematic/Static Model Of Complex Compliant Mechanisms With Serial-Parallel Substructures: A General Approach, Mingxiang Ling, Junyi Cao, Larry L. Howell

Faculty Publications

Kinematic and static analyses of compliant mechanisms are crucial at the early stage of design, and it can be difficult and laborsome for complex configurations with distributed compliance. In this paper, a general and concise kinematic/static modeling method of flexure-hinge-based compliant mechanisms with arbitrary serial-parallel substructures is presented to provide accurate and efficient solutions by combining the matrix displacement method with the transfer matrix method. The transition between the elemental stiffness matrix and the transfer matrix of the flexure hinge and the flexible beam is straightforward, enabling the condensation of a hybrid serial-parallel substructure into one equivalent element simple. Then, …