Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Brigham Young University

Discipline
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 541 - 570 of 8047

Full-Text Articles in Entire DC Network

Advanced Separations And Mass Spectrometry Data Acquisition Strategies To Improve Sensitivity And Throughput In Single-Cell Proteomics, Thy Truong Dec 2023

Advanced Separations And Mass Spectrometry Data Acquisition Strategies To Improve Sensitivity And Throughput In Single-Cell Proteomics, Thy Truong

Theses and Dissertations

Single Cell Proteomics (SCP) is an emerging discipline that contributes to a deeper understanding of individual cells' essential components. In biological systems, individual cells exhibit remarkable diversity, showcasing distinct proteomic profiles and functions. Mass Spectrometry (MS)-based techniques have become essential tools for exploring the proteomes of single cells with remarkable precision. While traditional bulk proteomics methods have been invaluable in revealing the overall protein composition of biological samples, they fall short in capturing the subtle nuances and heterogeneity among individual cells in a population. This limitation emphasizes the need for more targeted and detailed analyses to uncover the protein makeup …

Go to article

Synthesis Of Yaku'amide A Analogues And Progress Toward Synthesis Of Virosine A, Alexander S. Ramos Dec 2023

Synthesis Of Yaku'amide A Analogues And Progress Toward Synthesis Of Virosine A, Alexander S. Ramos

Theses and Dissertations

The first project in this dissertation endeavors to outline the total synthesis of yaku'amide A and its analogs. Yaku'amide A is a natural product comprised of dehydroamino acids, including E-dehydro isoleucine, and unprecedented Z-dehydro isoleucine. These amino acids present a significant challenge to their synthesis owing to their unsymmetrical nature. To simplify the synthesis process, we synthesized analogs by substituting the E and Z dehydroamino acids with symmetrical subunits. This substitution facilitated the synthesis process and enabled us to obtain a similar three-dimensional structure to that of the natural product. Furthermore, biological testing of the simplified analogs revealed potency similar …

Go to article

Student Thinking Driving Collaboration And Teacher Knowledge, Rachel Cheney Dec 2023

Student Thinking Driving Collaboration And Teacher Knowledge, Rachel Cheney

Theses and Dissertations

The study in this paper examined how teachers engaged in their structured Professional Learning Community (PLC) time in a manner that focused their work on student mathematical thinking. The participants included two third-grade teachers and two fourth-grade teachers engaged in an alternative PLC process during their collaboration time. Interviews were conducted and focused on how the teachers thought about student thinking as the driving force of their collaboration. The teachers found their PLC time was more focused, student thinking led the discussions and lessons, they were more responsive to student needs, and their own mathematical understanding increased. The teachers also …

Go to article

Combined Design And Dispatch Optimization For Nuclear-Renewable Hybrid Energy Systems, Daniel Clyde Hill Dec 2023

Combined Design And Dispatch Optimization For Nuclear-Renewable Hybrid Energy Systems, Daniel Clyde Hill

Theses and Dissertations

Reliable, affordable access to electrical power is a requirement for almost all aspects of developed societies. Challenges associated with reducing carbon emissions has led to growing interest in nuclear-renewable hybrid energy systems (N-RHES). Much work has already been done in suggesting and analyzing various N-RHES using a variety of optimization techniques and assumptions. This work builds upon previous techniques for simultaneous combined design and dispatch optimization (CDDO) for hybrid energy systems (HES). The first contribution of this work is the development and application of sensitivity analysis tailored to the combined design and dispatch optimization problem. This sensitivity analysis cover uncertainty …

Go to article

Dynamic Segmental Kinematics Of The Lumbar Spine During Diagnostic Movements, Paul Mcmullin Dec 2023

Dynamic Segmental Kinematics Of The Lumbar Spine During Diagnostic Movements, Paul Mcmullin

Theses and Dissertations

While lumbar kinematics can be measured in vivo, most measurements are invasive (such as percutaneous bone pins), provide high doses of radiation (such as biplane fluoroscopy), or are taken with the patient in a static position (such as MRIs). Recent work suggests that lumbar kinematics can be determined by dynamic measurements of epidermal strain in the lower back. This work aims to develop and examine a method of examining lumbar kinematics via optoelectronic motion capture utilizing skin-mounted markers in the lumbar region. Two studies were performed. One study examined lumbar epidermal strain in 28 asymptomatic subjects during diagnostic movements, while …

Go to article

Soft Robot Trajectory Generation: Enabling Soft Robot Arms To Reliably And Effectively Perform Real World Tasks Through Optimization, Haley P. Sanders Dec 2023

Soft Robot Trajectory Generation: Enabling Soft Robot Arms To Reliably And Effectively Perform Real World Tasks Through Optimization, Haley P. Sanders

Theses and Dissertations

The robotic platform presented in this thesis is underdamped with high inertia and can store potential energy in its compliant joints, making it ideal for many different types of real-world tasks for which traditional rigid-robots are ill-suited. Some real-world tasks suited to soft robots include high impact tasks like hammering a nail into a wall or moving heavy objects with other robot or human teammates while using relatively little power. Some of the same characteristics which make soft robots useful, such as their underdamped, highly compliant joints, also make motion planning and control for soft robots difficult. In this thesis, …

Go to article

View Dependent Simplification And Tessellation For Real-Time High Quality Rendering Of 3d Meshes, Dallin M. Hagman Dec 2023

View Dependent Simplification And Tessellation For Real-Time High Quality Rendering Of 3d Meshes, Dallin M. Hagman

Theses and Dissertations

The increasing complexity of 3D meshes and growing disparity in performance between high and low-end hardware necessitates more efficient rendering techniques that do not sacrifice visual quality. To support as many hardware configurations as possible, producers of 3D content provide several resolutions of each mesh. Low-end hardware is typically restricted to low-resolution meshes to maintain performance similar to their high-end counterparts, sacrificing visual appeal. However, the presence of hardware tessellation in nearly all modern GPUs presents the opportunity to render high-resolution versions of simplified meshes on low-end hardware with little computational cost. Some research has been conducted into this opportunity, …

Go to article

Interfacial Properties Of Hybrid Lipid-Polymer Bilayers: Applications In Drug Delivery And Biosensors, Keith L. Willes Dec 2023

Interfacial Properties Of Hybrid Lipid-Polymer Bilayers: Applications In Drug Delivery And Biosensors, Keith L. Willes

Theses and Dissertations

Amphiphilic block copolymers are unique macro-molecules capable of self-assembling into bilayers analogous to naturally occurring lipid membranes. When combined with lipids, these copolymers form hybrid membranes with unique and sometimes unpredictable properties, including increased chemical and mechanical stability. These synthetically enhanced biological structures represent a versatile platform suitable for a wide range of applications, from advanced biosensing devices to drug delivery systems. The realization of these advancements necessitates a deep understanding of material properties, including the ability to predict and control interfacial behaviors. It has been shown that in the case of pure lipid membranes, interfacial behaviors are dominated by …

Go to article

Effectiveness Of Intelligent Transportation Systems On Utah Roadways, Matthew Cline Davis Dec 2023

Effectiveness Of Intelligent Transportation Systems On Utah Roadways, Matthew Cline Davis

Theses and Dissertations

This thesis presents the findings of a comprehensive research study conducted for the Utah Department of Transportation (UDOT) to evaluate the effectiveness of commonly deployed Intelligent Transportation System (ITS) treatments in Utah, with a focus on Variable Message Signs (VMS), traffic cameras, and Road Weather Information System(s) (RWIS) sites. The study aimed to determine the impact of these ITS treatments on mobility and safety for Utah's unique road conditions and configurations. Three primary analyses were performed: a diversion rates analysis to assess the effectiveness of VMS on Utah freeways during incidents; a weather analysis to evaluate the effectiveness of VMS …

Go to article

Modeling The Influence Of Vibration On Flow Through Embedded Microchannels, Joseph S. Seamons Dec 2023

Modeling The Influence Of Vibration On Flow Through Embedded Microchannels, Joseph S. Seamons

Theses and Dissertations

The influence of vocal fold (VF) vibration on perfused flow through VF vasculature is an area of research that has previously received limited attention. The aim of the research presented in this thesis was to contribute towards an improved understanding of the effects vibration on perfusion through vasculature within the VFs. This was done using a series of computational simulations of geometric changes to, and perfusion through, microchannels embedded in VF models. A computational structural model based on synthetic VF models used in previous experimental studies was first developed. The model and its embedded microchannel were initially studied under static …

Go to article

Using Quantitative And Kinetic Proteomics To Explore Proteostasis, Nathan Raul Zuniga Pina Dec 2023

Using Quantitative And Kinetic Proteomics To Explore Proteostasis, Nathan Raul Zuniga Pina

Theses and Dissertations

Every cell consists of carefully orchestrated biomolecules such as lipids, carbohydrates, and proteins. To maintain internal stability (homeostasis), cells maintain the right amount of these molecules at the right time and at the right place. This process is especially true for proteins since they are the foundation functional units within the cell. Proteins form structures and perform chemistry that bestows cells overarching functional roles. Cells maintain protein homeostasis (proteostasis) by modulating synthesis, folding, and degradation processes (turnover) to maintain the abundance levels for all proteins. This is the foundational kinetic model of proteostasis that is covered in this work, and …

Go to article

Coarsening Dynamics Of Ternary Polymer Solutions With Mobility And Viscosity Contrasts, Jan Ulric Garcia, Douglas R. Tree, Alyssa Bagoyo, Tatsuhiro Iwama, Kris T. Delaney, Glenn H. Fredrickson Dec 2023

Coarsening Dynamics Of Ternary Polymer Solutions With Mobility And Viscosity Contrasts, Jan Ulric Garcia, Douglas R. Tree, Alyssa Bagoyo, Tatsuhiro Iwama, Kris T. Delaney, Glenn H. Fredrickson

Faculty Publications

Using phase-field simulations, we investigate the bulk coarsening dynamics of ternary polymer solutions undergoing a glass transition for two models of phase separation: diffusion only and with hydrodynamics. The glass transition is incorporated in both models by imposing mobility and viscosity contrasts between the polymer-rich and polymer-poor phases of the evolving microstructure. For microstructures composed of polymer-poor clusters in a polymer-rich matrix, the mobility and viscosity contrasts significantly hinder coarsening, effectively leading to structural arrest. For microstructures composed of polymer-rich clusters in a polymer-poor matrix, the mobility and viscosity contrasts do not impede domain growth; rather, they change the transient …

Go to article

Full Issue Dec 2023

Full Issue

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

No abstract provided.

Go to article

What Does The Farms Logo Stand For? Dec 2023

What Does The Farms Logo Stand For?

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

Many people have asked what the F.A.R.M.S. logo means. Here is a brief explanation. The logo is composed of characters from Hebrew, Greek, Mayan and Egyptian, which are four of the main ancient languages and cultures relevant to Book of Mormon research. The characters are set in four stone blocks, symbolizing archaeology and ancient research.

Go to article

Announcing The Complete Collected Works Of Hugh Nibley Dec 2023

Announcing The Complete Collected Works Of Hugh Nibley

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

On March 31, 1985, Hugh Nibley will celebrate his 75th birthday. "The time has come," says Gary Gillum, "to compile and publish the Complete Collected Works of Hugh Nibley." F.A.R.M.S. is pleased to announce that arrangements for this significant publication have now been made. This monumental series will be jointly published by Dr. Nibley, F.A.R.M.S. and Deseret Book Company, with the cooperation of Bookcraft and others. This series culminates six F.A.R.M.S. projects involving the Nibley collection, including the Nibley bibliography, archive, reprint service, topical index, source index, and scriptural index.

Go to article

Design And Implementation Of A Software System For Measuring Cookstove Emissions In Peru, Cody Arvonen Dec 2023

Design And Implementation Of A Software System For Measuring Cookstove Emissions In Peru, Cody Arvonen

Undergraduate Honors Theses

The particulate matter (PM), carbon monoxide (CO), and carbon dioxide (CO2) emitted from cookstoves cause many potential health and environmental risks. This work outlines the design of a sensor system to accurately and affordably measure these gas quantities to aid in the certification of cookstoves for a laboratory in Peru. Our team was able to design and build this system at a price ten times reduced than the current commercial sensor unit in use. The performance of our sensor system was verified by comparing its PM and CO trends to that of the commercial unit. After testing, we …

Go to article

Cooperative Observing At A Modest-Sized Observatory, Michael D. Joner, Denzil E. Watts Iv, Seneca H. Bahr, Oliver Hancock, Michael W. Holland, Hafsa Jamil, Eden Saxton, Malaya Williams-Jones Dec 2023

Cooperative Observing At A Modest-Sized Observatory, Michael D. Joner, Denzil E. Watts Iv, Seneca H. Bahr, Oliver Hancock, Michael W. Holland, Hafsa Jamil, Eden Saxton, Malaya Williams-Jones

BYU West Mountain Observatory Project

The West Mountain Observatory is an astronomical research facility operated by Brigham Young University, located on an isolated mountain approximately 22 kilometers southwest of the main Provo UT campus. The observatory was upgraded 15 years ago and has since been utilized primarily as an undergraduate research facility. The observatory is well suited to do work on projects utilizing time series photometric observations and has been particularly successful at conducting multiple projects for undergraduate student researchers that require observations of different durations and cadences using various filter combinations. This requires additional planning and cooperation between the different programs that are often …

Go to article

Video Games For The Win: Examining The Net Positive Impact On Emotional, Cognitive, And Social Aspects Of Mental Health In Today’S Youth, James Sanford Nov 2023

Video Games For The Win: Examining The Net Positive Impact On Emotional, Cognitive, And Social Aspects Of Mental Health In Today’S Youth, James Sanford

Student Works

Video games are becoming an integral part of society, as more than 90% of adolescents play them often, and the industry is growing in revenue every year (Granic et al., 2014). However, many mainstream media outlets portray video games as detrimental to mental health and damaging to cognitive abilities, with initial research into video games initially corroborating such claims and finding correlations to violent behavior (Ferguson, 2020). These early research methods could have been more robust; moreover, focusing on only the negative aspects of gaming research significantly reduced their ability to properly understand gaming’s full impact. Video games typically encourage …

Go to article

An Analysis Of Float Serves In Women's Collegiate Volleyball, Emily Logan Nov 2023

An Analysis Of Float Serves In Women's Collegiate Volleyball, Emily Logan

Undergraduate Honors Theses

Volleyball coaches generally have the belief that getting a serve to float, i.e. hitting the ball in such a way that spin is minimized causing unpredictability in the ball’s movement in the air, is the aspect that makes the ball most difficult to pass. This analysis explores whether or not a serve floats, the serve’s direction, location, and speed to determine what creates the most effective serve in regards to pass rating. The findings show that successfully getting the ball to float on a serve is indeed important. Also, serving the person immediately across from the server, and serving to …

Go to article

Stability, Longevity, And Regulatory Bionetworks, Christian N. K. Anderson Nov 2023

Stability, Longevity, And Regulatory Bionetworks, Christian N. K. Anderson

Theses and Dissertations

Genome-wide studies of diseases and chronic conditions frequently fail to uncover marked or consistent differences in RNA or protein concentrations. However, the developing field of kinetic proteomics has made promising discoveries in differences in the turnover rate of these same proteins, even when concentrations were not necessarily different. The situation can theoretically be modeled mathematically using bifurcation equations, but uncovering the proper form of these is difficult. To this end, we developed TWIG, a method for characterizing bifurcations that leverages information geometry to identify drivers of complex systems. Using this, we characterized the bifurcation and stability properties of all 132 …

Go to article

Advancements In Molten Salt Physical Property Measurement: Archimedean Density, Couette Viscometer, And Flibe-Te Solution Penetration Analysis, Kent Powell Detrick Nov 2023

Advancements In Molten Salt Physical Property Measurement: Archimedean Density, Couette Viscometer, And Flibe-Te Solution Penetration Analysis, Kent Powell Detrick

Theses and Dissertations

This work primarily centers on measuring the physical properties of molten salts. It's dedicated to outlining the methodology, enhancing measurement methods, and scrutinizing data to uncover insights regarding the interaction between molten salt and solid structures in the context of designing and generating electrical energy in molten salt reactors. The initial phase of this research involved collaborating with Brigham Young University's molecular dynamics simulation group to create an Archimedean density measurement device. This endeavor was primarily geared towards generating empirical data for the purpose of enhancing molecular dynamics simulation data. The tasks encompassed designing and validating the experimental setup, with …

Go to article

Equation-Based And Data-Driven Modeling: Open-Source Software Current State And Future Directions, Lagrande Gunnell, Bethany Nicholson, John Hedengren Nov 2023

Equation-Based And Data-Driven Modeling: Open-Source Software Current State And Future Directions, Lagrande Gunnell, Bethany Nicholson, John Hedengren

Faculty Publications

A review of current trends in scientific computing reveals a broad shift to open-source and higher-level programming languages such as Python and growing career opportunities over the next decade. Open-source modeling tools accelerate innovation in equation-based and data-driven applications. Significant resources have been deployed to develop data-driven tools (PyTorch, TensorFlow, Scikit-learn) from tech companies that rely on machine learning services to meet business needs while keeping the foundational tools open. Open-source equation-based tools such as Pyomo, CasADi, Gekko, and JuMP are also gaining momentum according to user community and development pace metrics. Integration of data-driven and principles-based tools is emerging. …

Go to article

Passive Positioning Using Linear Multilateration, Eric R. Widdison Nov 2023

Passive Positioning Using Linear Multilateration, Eric R. Widdison

Theses and Dissertations

Passive localization of aircraft in flight using signal time of arrival (TOA) poses some unique challenges. The sensors must be deployed in an approximately coplanar configuration, which produces significant vertical uncertainty in the estimated position. This dissertation examines the traditional algorithms used in passive localization. It presents general forms of linear TOA, time difference of arrival (TDOA), angle of arrival (AOA), and frequency difference of arrival (FDOA) equations from the literature and explains how to apply an intuitive geometric interpretation of these equations. It presents two novel algorithms for passive localization. One uses a one dimensional AOA (1AOA) to improve …

Go to article

Malicious Game Client Detection Using Feature Extraction And Machine Learning, Spencer J. Austad Nov 2023

Malicious Game Client Detection Using Feature Extraction And Machine Learning, Spencer J. Austad

Theses and Dissertations

Minecraft, the world's best-selling video game, boasts a vast and vibrant community of users who actively develop third-party software for the game. However, it has also garnered notoriety as one of the most malware-infested gaming environments. This poses a unique challenge because Minecraft software has many community-specific nuances that make traditional malware analysis less effective. These differences include unique file types, differing code formats, and lack of standardization in user-generated content analysis. This research looks at Minecraft clients in the two most common formats: Portable Executable and Java Archive file formats. Feature correlation matrices showed that malware features are too …

Go to article

Analysis Of Benefits Of Udot's Expanded Incident Management Team Program, Joel Clegg Hyer Nov 2023

Analysis Of Benefits Of Udot's Expanded Incident Management Team Program, Joel Clegg Hyer

Theses and Dissertations

In 2019, the Utah Department of Transportation (UDOT) funded a research study evaluating the performance measures of UDOT's expanded Incident Management Team (IMT) program. The number of IMTs patrolling Utah roadways increased from 13 to 25 between 2018 and 2020. Crash data were collected from the Utah Highway Patrol's Computer Aided Dispatch database and from the UDOT TransSuite database to compare IMT performance measures between the two years and to evaluate the benefits of the expanded IMT program. However, these data were compromised due to the effects of the COVID-19 pandemic. This study collected data for 2022 using the same …

Go to article

Monitoring Brain Region-Specific Control Of Protein Turnover And Concentration Using Proteomics, Rebecca Suzanne Burlett Nov 2023

Monitoring Brain Region-Specific Control Of Protein Turnover And Concentration Using Proteomics, Rebecca Suzanne Burlett

Theses and Dissertations

Regulation of metabolism is vital to health and lies at the core of many different diseases. The breakdown of metabolisms' regulation within the brain can lead to neurological disease like Alzheimer's Disease (AD). AD is known to affect brain regions responsible for memory and memory processing like the hippocampus and entorhinal cortex. The regulation of these regions' protein quality, synthesis, and degradation deviate from 'normal' or 'healthy' levels when AD is happening. It is known there is a breakdown of regulation in those regions; however, little is known about the specifics of regulation in healthy brains regions or how it …

Go to article

Dispensing With Humans In Human-Computer Interaction Research, Courtni L. Byun Nov 2023

Dispensing With Humans In Human-Computer Interaction Research, Courtni L. Byun

Theses and Dissertations

Machine Learning models have become more advanced than could have been supposed even a few years ago, often surpassing human performance on many tasks. Large language models (LLM) can produce text indistinguishable from human-produced text. This begs the question, how necessary are humans - even for tasks where humans appear indispensable? Qualitative Analysis (QA) is integral to human-computer interaction research, requiring both human-produced data and human analysis of that data to illuminate human opinions about and experiences with technology. We use GPT-3 and ChatGPT to replace human analysis and then to dispense with human-produced text altogether. We find GPT-3 is …

Go to article

Inconsistent Correlation And Momenta: A New Approach To Portfolio Allocation, David Kercher Nov 2023

Inconsistent Correlation And Momenta: A New Approach To Portfolio Allocation, David Kercher

Theses and Dissertations

Correlated stocks should, in equilibrium, have correlated momenta, but in practice momenta do not always correlate. We use short-term inconsistencies between correlations and momenta to predict price corrections, produce more meaningful investment indicators, and improve upon accepted investing strategies. In particular, our approaches integrate inconsistencies within an entire security class rather than relying only on individual or pairwise security data. We use this theory to improve upon not only the standard momentum portfolio but also Pair Trading and Momentum Reversion methods. This results in three strategies for portfolio allocation that outperforms overlying indices and market benchmarks by 5%-10% in annual …

Go to article

Analog Artificial Neurons And Digital Amplifiers: Challenging The Roles Of Analog And Digital Circuit Architectures In Modern Cmos Processes, Taylor S. Barton Nov 2023

Analog Artificial Neurons And Digital Amplifiers: Challenging The Roles Of Analog And Digital Circuit Architectures In Modern Cmos Processes, Taylor S. Barton

Theses and Dissertations

As complimentary metal-oxide semiconductor (CMOS) technologies scale and field-effect transistor (FET) architectures change, the factors in deciding to utilize analog or digital transistor behaviors evolve. This thesis examines three case studies where traditionally analog or digital circuitry has dominated published works but I show that the opposite regime has significant benefits in scaled CMOS technologies. I present a highly digital operational amplifier (traditionally analog) and two artificial neurons (traditionally digital). In Chapters 2 and 3 I present a highly-digital five-stage zero-crossing-based amplifier which breaks the trade-off between slew rate and settling accuracy. I investigate the optimal charge pump design by …

Go to article

Developing 3d Printed Integrated Microfluidic Devices For Microchip Electrophoresis Separation Of Preterm Birth Biomarkers, Joule E. Esene Nov 2023

Developing 3d Printed Integrated Microfluidic Devices For Microchip Electrophoresis Separation Of Preterm Birth Biomarkers, Joule E. Esene

Theses and Dissertations

Preterm birth is a global health challenge and the leading cause of neonatal mortality. Each year, about 15 million babies are born preterm globally. Traditional tools that have been exploited for the detection of preterm birth biomarkers are expensive, time consuming, or lack multiplexing capabilities. The work described in this dissertation highlights techniques developed to detect preterm birth biomarkers rapidly and accurately in the effort to mitigate preterm birth risk. In this dissertation, I first demonstrated the use of stereolithography digital light processing-based 3D printing and microfluidics for the development of microfluidic devices that had microvalves for fluid control. I …

Go to article

First Prev Next Last